237561:CAALFM C303280CA
gene id: 237561:CAALFM_C303280CA
uniprot id: Q5AEE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated once deposited into chromatin.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (By similarity).
messages: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).

237561:CAALFM C204980CA
gene id: 237561:CAALFM_C204980CA
uniprot id: Q59ZI9
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C403510CA
gene id: 237561:CAALFM_C403510CA
uniprot id: Q59PF9
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Expressed in hyphae. Regulated by the EFG1 and TUP1 transcription factors.
messages: GPI-anchored cell wall protein required for mating efficiency, biofilm formation, adhesion, filamentous growth, and oxidative stress tolerance. Involved in normal disseminated infection in a mouse systemic candidiasis model.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C203260WA
gene id: 237561:CAALFM_C203260WA
uniprot id: Q5AH92
names: Similarity
messages: Belongs to the PITHD1 family.

237561:CAALFM C110550CA
gene id: 237561:CAALFM_C110550CA
uniprot id: A0A1D8PEW1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

237561:CAALFM CR06960WA
gene id: 237561:CAALFM_CR06960WA
uniprot id: Q59SM3
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C203880CA
gene id: 237561:CAALFM_C203880CA
uniprot id: A0A1D8PH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

237561:CAALFM C501270WA
gene id: 237561:CAALFM_C501270WA
uniprot id: A0A1D8PN41
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201120WA
gene id: 237561:CAALFM_C201120WA
uniprot id: A0A1D8PG96
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

237561:CAALFM C201030WA
gene id: 237561:CAALFM_C201030WA
uniprot id: A0A1D8PG94
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

237561:CAALFM C104100CA
gene id: 237561:CAALFM_C104100CA
uniprot id: P83781
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of membrane-spanning sided beta-sheets.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Mitochondrion outer membrane

237561:CAALFM C405540WA
gene id: 237561:CAALFM_C405540WA
uniprot id: A0A1D8PMB8
names: Similarity
messages: Belongs to the aspartokinase family.

237561:CAALFM C402420CA
gene id: 237561:CAALFM_C402420CA
uniprot id: Q5AFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane

237561:CAALFM C405920CA
gene id: 237561:CAALFM_C405920CA
uniprot id: Q59QA5
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C504150CA
gene id: 237561:CAALFM_C504150CA
uniprot id: Q5AKC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM C111480WA
gene id: 237561:CAALFM_C111480WA
uniprot id: A0A1D8PF54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR03660CA
gene id: 237561:CAALFM_CR03660CA
uniprot id: A0A1D8PSJ0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

237561:CAALFM C600330CA
gene id: 237561:CAALFM_C600330CA
uniprot id: Q59RL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

237561:CAALFM C207890WA
gene id: 237561:CAALFM_C207890WA
uniprot id: Q5A2L2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

237561:CAALFM C304160WA
gene id: 237561:CAALFM_C304160WA
uniprot id: Q5ANP1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C604590CA
gene id: 237561:CAALFM_C604590CA
uniprot id: Q04802
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: By N-acetylglucosamine.
messages: Monomer.

237561:CAALFM C303880CA
gene id: 237561:CAALFM_C303880CA
uniprot id: A0A1D8PJS7
names: Similarity
messages: Belongs to the VPS26 family.

237561:CAALFM C105840WA
gene id: 237561:CAALFM_C105840WA
uniprot id: A0A1D8PDN9
names: Similarity
messages: Belongs to the pirin family.

237561:CAALFM C700860WA
gene id: 237561:CAALFM_C700860WA
uniprot id: Q5AFN8
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCW14 family.
messages: Beta-glucan associated cell wall protein involved in cell wall structure. May serve as cross-linking or coat-forming wall protein.
messages: Expressed in both yeast and hyphal cells at the same level, indicating that it has no morphological differential expression. Expression is slightly increased by fluconazole.
messages: Leads to increased sensitivity to caspofungin, Congo red, calcofluor white, and zymolyase.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C201640WA
gene id: 237561:CAALFM_C201640WA
uniprot id: Q5ALV2
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Cell tip
messages: Component of the PAN1 actin cytoskeleton-regulatory complex (By similarity). Interacts with PAN1 and CLN3.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Required for assembly of the cortical actin cytoskeleton and for hyphal growth.
messages: Endosome membrane
messages: Expression is regulated by NRG1 and MIG1.
messages: Nucleus
messages: Phosphorylated by the CDC28-CLN3 complex and by PRK1. CDC28-CLN3 phosphorylation regulates cortical actin patch dynamics, as well as PRK1 phosphorylation and SLA1 association with PAN1. Rapidly dephosphorylated upon hyphal induction.
messages: The N-terminal SH3 domains are important for actin cytoskeleton assembly but not for localization.
messages: actin patch

237561:CAALFM C403070WA
gene id: 237561:CAALFM_C403070WA
uniprot id: Q5AFC2
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expression is induced during infection of reconstituted human oral epithelium. Expression is repressed by HOG1 and regulated by TEC1, EGF1, NTD80, ROB1, BRG1, and SSN6.

237561:CAALFM C403150WA
gene id: 237561:CAALFM_C403150WA
uniprot id: Q5AFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

237561:CAALFM C703790WA
gene id: 237561:CAALFM_C703790WA
uniprot id: A0A1D8PRG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Mitochondrion

237561:CAALFM C701280CA
gene id: 237561:CAALFM_C701280CA
uniprot id: A0A1D8PQV5
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

237561:CAALFM CR09700WA
gene id: 237561:CAALFM_CR09700WA
uniprot id: A0A1D8PU21
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C207960CA
gene id: 237561:CAALFM_C207960CA
uniprot id: Q5A2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSA1 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM C500280CA
gene id: 237561:CAALFM_C500280CA
uniprot id: Q5A4X9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

237561:CAALFM C106980CA
gene id: 237561:CAALFM_C106980CA
uniprot id: A0A1D8PDZ8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109250WA
gene id: 237561:CAALFM_C109250WA
uniprot id: A0A1D8PEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

237561:CAALFM C207330WA
gene id: 237561:CAALFM_C207330WA
uniprot id: A0A1D8PHX3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

237561:CAALFM C303170WA
gene id: 237561:CAALFM_C303170WA
uniprot id: Q5AEF2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
messages: Endoplasmic reticulum membrane
messages: Has antigenic properties.
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
messages: nuclear pore complex

237561:CAALFM C404080CA
gene id: 237561:CAALFM_C404080CA
uniprot id: Q5A5U9
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host (By similarity). Involved in the regulation or assembly of chitin within the cell wall.
messages: Expression is regulated upon white-opaque switch, during cell wall regeneration, and when cells are grown on lactate. Also up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment. Repressed by BCR1.
messages: Leads to hypersensitivity to caspofungin.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C401070WA
gene id: 237561:CAALFM_C401070WA
uniprot id: A0A1D8PL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C406260WA
gene id: 237561:CAALFM_C406260WA
uniprot id: Q5A1A9
names: Subcellular Location Annotation
messages: Cell membrane

237561:CAALFM C302020WA
gene id: 237561:CAALFM_C302020WA
uniprot id: Q5AJS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM MRD1 family.
messages: Involved in pre-rRNA processing.
messages: Nucleus

237561:CAALFM C201220WA
gene id: 237561:CAALFM_C201220WA
uniprot id: A0A1D8PGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

237561:CAALFM C107980CA
gene id: 237561:CAALFM_C107980CA
uniprot id: A0A1D8PE61
names: Similarity
messages: Belongs to the SWI5/SAE3 family.

237561:CAALFM CR08090WA
gene id: 237561:CAALFM_CR08090WA
uniprot id: Q5A397
names: Similarity
messages: Belongs to the heat shock protein 70 family.

237561:CAALFM C202010CA
gene id: 237561:CAALFM_C202010CA
uniprot id: Q5AM60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in sporulation.
messages: Secreted

237561:CAALFM C602120WA
gene id: 237561:CAALFM_C602120WA
uniprot id: A0A1D8PPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Cytoplasmic vesicle membrane
messages: coated pit

237561:CAALFM C700510WA
gene id: 237561:CAALFM_C700510WA
uniprot id: Q5AFK0
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth.
messages: Expression is inhibited in the presence of copper. Expression is increased in polymicrobial biofilms during coinfection with S.aureus.
messages: Nucleus
messages: Results in reduced growth on copper or iron depleted media and the inability to grow on media with a non-fermentable carbon source.

237561:CAALFM C301030WA
gene id: 237561:CAALFM_C301030WA
uniprot id: Q5A9X7
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM CR09300CA
gene id: 237561:CAALFM_CR09300CA
uniprot id: A0A1D8PTX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

237561:CAALFM C111980WA
gene id: 237561:CAALFM_C111980WA
uniprot id: Q5A3K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM CR10210WA
gene id: 237561:CAALFM_CR10210WA
uniprot id: Q5ACP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cell membrane

237561:CAALFM C406920CA
gene id: 237561:CAALFM_C406920CA
uniprot id: Q5A0X8
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: CSA2 could be used as a new diagnostic marker of Candida albicans infection.
messages: Expression is induced during hyphal growth, by ketoconazole, and nitric oxide. Expression is also regulated by RIM101, TSA1, HAP43 and BCR1.
messages: Homodimer (PubMed:27617569). The possibility of a transient honotrimer assembly of the holo protein is not ruled out (PubMed:27617569).
messages: Leads to defects in hemoglobin utilization as sole source of iron.
messages: Secreted
messages: Secreted heme-binding protein involved in the utilization of iron from human hemoglobin during hyphal growth (PubMed:24796871, PubMed:27617569). May also play a role in non-hemoglobin iron utilization (PubMed:24796871). Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade (PubMed:27617569). The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms (PubMed:24796871).
messages: The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (PubMed:27617569). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (PubMed:27617569).

237561:CAALFM C112350WA
gene id: 237561:CAALFM_C112350WA
uniprot id: Q5A3P1
names: Similarity
messages: Belongs to the RNR ribonuclease family.

237561:CAALFM C206100WA
gene id: 237561:CAALFM_C206100WA
uniprot id: Q59X23
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Forms a functional homodimer.
messages: Impairs biofilm formation and shows reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE).
messages: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation.
messages: Transcribed in the yeast form, but expression is increased two to threefold during hyphal induction. Also up-regulated more than twofold when PMT1 expression is impaired. MSB2 functions not only to secure basal levels of the PMT4 transcripts but is needed also for up-regulation of both transcripts upon PMT1 inhibition. Repressed by BCR1.

237561:CAALFM C703910WA
gene id: 237561:CAALFM_C703910WA
uniprot id: A0A1D8PRH2
names: Similarity
messages: Belongs to the type-1 OGG1 family.

237561:CAALFM C107680WA
gene id: 237561:CAALFM_C107680WA
uniprot id: A0A1D8PE35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

237561:CAALFM C104420CA
gene id: 237561:CAALFM_C104420CA
uniprot id: Q59KZ3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

237561:CAALFM C204260WA
gene id: 237561:CAALFM_C204260WA
uniprot id: Q5AHK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the SRB8-11 complex, a regulatory module of the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
messages: Nucleus

237561:CAALFM C207670CA
gene id: 237561:CAALFM_C207670CA
uniprot id: Q5A2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

237561:CAALFM C405670WA
gene id: 237561:CAALFM_C405670WA
uniprot id: A0A1D8PME0
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C112780WA
gene id: 237561:CAALFM_C112780WA
uniprot id: A0A1D8PFI3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

237561:CAALFM CR01920WA
gene id: 237561:CAALFM_CR01920WA
uniprot id: Q5A975
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C206940CA
gene id: 237561:CAALFM_C206940CA
uniprot id: Q59Z52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

237561:CAALFM C405910CA
gene id: 237561:CAALFM_C405910CA
uniprot id: A0A1D8PMF6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.
messages: Vacuole membrane

237561:CAALFM C601870CA
gene id: 237561:CAALFM_C601870CA
uniprot id: Q5A4P7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C207940CA
gene id: 237561:CAALFM_C207940CA
uniprot id: A0A1D8PI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C307410CA
gene id: 237561:CAALFM_C307410CA
uniprot id: Q5ADU2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C200440WA
gene id: 237561:CAALFM_C200440WA
uniprot id: Q5ACY2
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

237561:CAALFM C201310WA
gene id: 237561:CAALFM_C201310WA
uniprot id: Q5AD73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endomembrane system
messages: Endosome membrane
messages: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

237561:CAALFM C602010CA
gene id: 237561:CAALFM_C602010CA
uniprot id: Q59W33
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: In presence of estrogen; decreases binding of host complement factor H protein and increases phagocytosis of the fungus by host (PubMed:34986357). Decreases virulence in presence of estrogen in a zebrafish larval model of infection (PubMed:34986357).
messages: Interacts with human CFH/complement factor H; the interaction is direct and enables the pathogen to evade the host innate immune system (PubMed:23204165). Interacts with human CFHR1/complement factor H-related protein 1; the interaction is direct (PubMed:23204165). Interacts with human PLG/plasminogen; the interaction is direct and provides active plasmin on the surface of fungal cells (PubMed:23204165).
messages: May catalyze the production and accumulation of glycerol during hyperosmotic stress conditions (By similarity). Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells (By similarity). Mediates evasion of the host innate immune system by binding inhibitory components of the host alternative complement system, in a manner dependent on estrogen-induced inhibition of EBP1 (PubMed:34986357, PubMed:23204165).
messages: Mildly induced by estrogen (17beta-estradiol).
messages: Peroxisome
messages: Secreted
messages: cell wall

237561:CAALFM CR04180CA
gene id: 237561:CAALFM_CR04180CA
uniprot id: Q5A6Q0
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM C201560WA
gene id: 237561:CAALFM_C201560WA
uniprot id: Q5ALW2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan.
messages: Expression is induced in biofilm.
messages: Membrane

237561:CAALFM C701510WA
gene id: 237561:CAALFM_C701510WA
uniprot id: Q5AGW0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C105700WA
gene id: 237561:CAALFM_C105700WA
uniprot id: P0C075
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Attenuates tolerance to oxidative stress when PEX1 is also deleted (PubMed:27473887). Leads to hypersensitivity to ER stress and causes the loss of virulence when YSY6 is also deleted (PubMed:29544880).
messages: Belongs to the ATG8 family.
messages: Induced during biofilm formation.
messages: The C-terminal 19 residues are removed to expose Gly-116 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.
messages: Ubiquitin-like modifier involved in autophagosomes formation (By similarity). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Participates also in membrane fusion events that take place in the early secretory pathway (By similarity). Regulates autophagy-related endoplasmic reticulum stress response (PubMed:29544880, PubMed:36328097). Also involved in resistance to oxidative stress (PubMed:27473887). Is essential for virulence (PubMed:29544880).
messages: Vacuole membrane
messages: autophagosome membrane

237561:CAALFM C207250CA
gene id: 237561:CAALFM_C207250CA
uniprot id: Q59Z18
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

237561:CAALFM C200360CA
gene id: 237561:CAALFM_C200360CA
uniprot id: A0A1D8PG26
names: Similarity
messages: Belongs to the peptidase M24B family.

237561:CAALFM C109630WA
gene id: 237561:CAALFM_C109630WA
uniprot id: A0A1D8PEM5
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

237561:CAALFM C102610WA
gene id: 237561:CAALFM_C102610WA
uniprot id: Q5AIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Vacuole membrane

237561:CAALFM CR00430CA
gene id: 237561:CAALFM_CR00430CA
uniprot id: A0A1D8PRQ4
names: Similarity
messages: Belongs to the BolA/IbaG family.

237561:CAALFM C205970CA
gene id: 237561:CAALFM_C205970CA
uniprot id: Q59MF1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

237561:CAALFM C109420WA
gene id: 237561:CAALFM_C109420WA
uniprot id: Q5APG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C207740WA
gene id: 237561:CAALFM_C207740WA
uniprot id: Q5A2K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: May act as a negative regulator of salt tolerance.

237561:CAALFM C603160CA
gene id: 237561:CAALFM_C603160CA
uniprot id: Q5ABU8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan. Required for pro-inflammatory response in macrophages through phospholipomannan-induced TNF-alpha production.
messages: Expression is induced in biofilm.
messages: Leads to the production of phospholipomannan with short truncated oligomannosidic chain and impairs induction of TNF-alpha production in macrophages.
messages: Membrane

237561:CAALFM C402050WA
gene id: 237561:CAALFM_C402050WA
uniprot id: Q5AMR0
names: Similarity
messages: Belongs to the HGH1 family.

237561:CAALFM CR03550WA
gene id: 237561:CAALFM_CR03550WA
uniprot id: Q59ZY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

237561:CAALFM C407070WA
gene id: 237561:CAALFM_C407070WA
uniprot id: A0A1D8PMS5
names: Similarity
messages: Belongs to the APC13 family.

237561:CAALFM C303450CA
gene id: 237561:CAALFM_C303450CA
uniprot id: Q5AEC6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.
messages: Expression is induced by HAP43 and down-regulated in an azole-resistant strain.
messages: Membrane

237561:CAALFM C500660CA
gene id: 237561:CAALFM_C500660CA
uniprot id: P10613
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Induced after prolonged growth with antifungal drugs such as clotrimazole, miconazole, fluconazole, itraconazole, ketoconazole, terbinafine and fenpropimorph.
messages: Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:8647850, PubMed:9559662, PubMed:10393548, PubMed:28258218). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (PubMed:8647850, PubMed:10393548, PubMed:28258218, PubMed:9559662). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
messages: The catalytic activity is inhibited by the binding of azoles clotrimazole, miconazole, fluconazole, ketoconazole, oteseconazole (VT-1161), tetraconazole, the triazole SCH39304, and the triazole derivative ICI 153066.

237561:CAALFM C103230CA
gene id: 237561:CAALFM_C103230CA
uniprot id: Q5AI37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.
messages: Cytoplasm
messages: Nucleus
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).

237561:CAALFM C503860WA
gene id: 237561:CAALFM_C503860WA
uniprot id: Q59N80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

237561:CAALFM C208810CA
gene id: 237561:CAALFM_C208810CA
uniprot id: P83777
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase family.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

237561:CAALFM CR05150WA
gene id: 237561:CAALFM_CR05150WA
uniprot id: A0A1D8PSW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

237561:CAALFM C306360CA
gene id: 237561:CAALFM_C306360CA
uniprot id: A0A1D8PKL0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C206340WA
gene id: 237561:CAALFM_C206340WA
uniprot id: Q59P39
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1/PHD1/stuA family.
messages: Exhibits increased colonization of the murine intestinal tract, a model of commensal colonization.
messages: Nucleus
messages: Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis.

237561:CAALFM C108160WA
gene id: 237561:CAALFM_C108160WA
uniprot id: A0A1D8PEB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

237561:CAALFM CR05380CA
gene id: 237561:CAALFM_CR05380CA
uniprot id: A0A1D8PT03
names: Similarity
messages: Belongs to the WrbA family.

237561:CAALFM CR08950WA
gene id: 237561:CAALFM_CR08950WA
uniprot id: A0A1D8PTX1
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM C405320WA
gene id: 237561:CAALFM_C405320WA
uniprot id: P43065
names: Function
names: Sequence Caution
names: Similarity
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
messages: Monomer.
messages: The coordinates of this ORF in the reference genome reflect non-intron adjustments made to compensate for presumed sequencing errors.

237561:CAALFM C202690WA
gene id: 237561:CAALFM_C202690WA
uniprot id: Q5A0H3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

237561:CAALFM CR08150WA
gene id: 237561:CAALFM_CR08150WA
uniprot id: Q5A389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C702100WA
gene id: 237561:CAALFM_C702100WA
uniprot id: A0A1D8PR11
names: Function
names: Similarity
messages: Belongs to the peptidase M24 family.
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.

237561:CAALFM C500290WA
gene id: 237561:CAALFM_C500290WA
uniprot id: Q5A4Y0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

237561:CAALFM C201340WA
gene id: 237561:CAALFM_C201340WA
uniprot id: A0A1D8PGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

237561:CAALFM CR03900WA
gene id: 237561:CAALFM_CR03900WA
uniprot id: Q5A6T5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

237561:CAALFM C110870WA
gene id: 237561:CAALFM_C110870WA
uniprot id: A0A1D8PEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C108210CA
gene id: 237561:CAALFM_C108210CA
uniprot id: Q5A762
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Is 10-fold down-regulated during log phase and strongly induced at the diauxic shift. Expression remains high during the postdiauxic phase and continues into stationary phase. Is also up-regulated during the presence of cadmium ions.
messages: Leads to decreased sublethal intraperitoneal infection in mice.
messages: Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence.
messages: Vacuole membrane

237561:CAALFM C402670WA
gene id: 237561:CAALFM_C402670WA
uniprot id: A0A1D8PLM0
names: Similarity
messages: Belongs to the beclin family.

237561:CAALFM C700100WA
gene id: 237561:CAALFM_C700100WA
uniprot id: A0A1D8PQI6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C105470WA
gene id: 237561:CAALFM_C105470WA
uniprot id: A0A1D8PDJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C406830CA
gene id: 237561:CAALFM_C406830CA
uniprot id: A0A1D8PMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

237561:CAALFM C207300CA
gene id: 237561:CAALFM_C207300CA
uniprot id: A0A1D8PHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

237561:CAALFM C305100CA
gene id: 237561:CAALFM_C305100CA
uniprot id: A0A1D8PK43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR03570CA
gene id: 237561:CAALFM_CR03570CA
uniprot id: A0A1D8PSH7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

237561:CAALFM C100940WA
gene id: 237561:CAALFM_C100940WA
uniprot id: A0A1D8PCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

237561:CAALFM C102530CA
gene id: 237561:CAALFM_C102530CA
uniprot id: A0A1D8PCR4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR07750CA
gene id: 237561:CAALFM_CR07750CA
uniprot id: Q59MW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Associated with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C502270WA
gene id: 237561:CAALFM_C502270WA
uniprot id: A0A1D8PNG9
names: Similarity
messages: Belongs to the threonine synthase family.

237561:CAALFM C704100CA
gene id: 237561:CAALFM_C704100CA
uniprot id: A0A1D8PRH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C104610WA
gene id: 237561:CAALFM_C104610WA
uniprot id: A0A1D8PDC4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

237561:CAALFM C207400CA
gene id: 237561:CAALFM_C207400CA
uniprot id: Q59U59
names: Similarity
messages: Belongs to the peptidase A1 family.

237561:CAALFM C104550WA
gene id: 237561:CAALFM_C104550WA
uniprot id: Q59RB3
names: Similarity
messages: Belongs to the SKP1 family.

237561:CAALFM C306210CA
gene id: 237561:CAALFM_C306210CA
uniprot id: A0A1D8PKL7
names: Similarity
messages: Belongs to the MUB1/samB family.

237561:CAALFM C306750WA
gene id: 237561:CAALFM_C306750WA
uniprot id: A0A1D8PKK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C102300WA
gene id: 237561:CAALFM_C102300WA
uniprot id: Q59VX1
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

237561:CAALFM C400090WA
gene id: 237561:CAALFM_C400090WA
uniprot id: A0A1D8PKY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

237561:CAALFM C603080CA
gene id: 237561:CAALFM_C603080CA
uniprot id: A0A1D8PQ26
names: Function
names: Similarity
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.

237561:CAALFM C601380CA
gene id: 237561:CAALFM_C601380CA
uniprot id: Q5A4J5
names: Similarity
messages: Belongs to the MOG1 family.

237561:CAALFM C104080WA
gene id: 237561:CAALFM_C104080WA
uniprot id: Q59VQ3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAD2 family.
messages: Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense.
messages: Component of the mitotic checkpoint complex (MCC).
messages: Nucleus
messages: Quickly loses viability when treated with nocodazole, which causes disassembly of mitotic spindles. Exhibits increased frequency of chromosome loss and greatly reduced virulence in mice.

237561:CAALFM C701560CA
gene id: 237561:CAALFM_C701560CA
uniprot id: Q5AGW8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
messages: Belongs to the NUP family.
messages: Mammalian nucleoside transport inhibitors dipyridamole and NBMPR inhibit adenosine transport by NUP.
messages: Nucleoside permease that transports adenosine and guanosine. Does not show any transport activities towards cytidine, adenine, guanine, uridine, and uracil.
messages: Predicted to be a substrate for cleavage by KEX2.

237561:CAALFM CR07090WA
gene id: 237561:CAALFM_CR07090WA
uniprot id: A0A1D8PTE0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

237561:CAALFM CR06660WA
gene id: 237561:CAALFM_CR06660WA
uniprot id: A0A1D8PTA4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C702180CA
gene id: 237561:CAALFM_C702180CA
uniprot id: Q5AH42
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

237561:CAALFM C205670CA
gene id: 237561:CAALFM_C205670CA
uniprot id: Q59T38
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

237561:CAALFM C205340CA
gene id: 237561:CAALFM_C205340CA
uniprot id: A0A1D8PHD8
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

237561:CAALFM C110200CA
gene id: 237561:CAALFM_C110200CA
uniprot id: Q5AP74
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C101600WA
gene id: 237561:CAALFM_C101600WA
uniprot id: A0A1D8PCJ1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

237561:CAALFM C206220CA
gene id: 237561:CAALFM_C206220CA
uniprot id: Q59P51
names: Similarity
messages: Belongs to the HUS1 family.

237561:CAALFM C403860CA
gene id: 237561:CAALFM_C403860CA
uniprot id: Q59LD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUR1 family.
messages: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
messages: Membrane
messages: Nucleus membrane

237561:CAALFM CR05970CA
gene id: 237561:CAALFM_CR05970CA
uniprot id: Q5A283
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C104300CA
gene id: 237561:CAALFM_C104300CA
uniprot id: P46587
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Binds HTN3/histatin-5, a peptide from human saliva, and mediates its fungicidal activity.
messages: Cytoplasm
messages: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.
messages: cell wall

237561:CAALFM C200390CA
gene id: 237561:CAALFM_C200390CA
uniprot id: Q5ACX5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

237561:CAALFM C603350CA
gene id: 237561:CAALFM_C603350CA
uniprot id: Q5AC48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP4 subfamily.
messages: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.
messages: Nucleus

237561:CAALFM C101740WA
gene id: 237561:CAALFM_C101740WA
uniprot id: Q59T80
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

237561:CAALFM C201010WA
gene id: 237561:CAALFM_C201010WA
uniprot id: A0A1D8PG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C103620CA
gene id: 237561:CAALFM_C103620CA
uniprot id: P0CU35
uniprot id: Q96W54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU) (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (Probable).
messages: Cytoplasm

237561:CAALFM C600370CA
gene id: 237561:CAALFM_C600370CA
uniprot id: Q59S06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules (By similarity).
messages: nucleolus

237561:CAALFM C301310WA
gene id: 237561:CAALFM_C301310WA
uniprot id: Q5AJ72
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C500470CA
gene id: 237561:CAALFM_C500470CA
uniprot id: Q5A504
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

237561:CAALFM C104790WA
gene id: 237561:CAALFM_C104790WA
uniprot id: Q59VH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

237561:CAALFM C600710WA
gene id: 237561:CAALFM_C600710WA
uniprot id: A0A1D8PPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

237561:CAALFM C208050CA
gene id: 237561:CAALFM_C208050CA
uniprot id: Q5A2T6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR10550WA
gene id: 237561:CAALFM_CR10550WA
uniprot id: Q5ACK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in ribosome assembly.
messages: Associates with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM CR07170WA
gene id: 237561:CAALFM_CR07170WA
uniprot id: A0A1D8PTE1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C203940CA
gene id: 237561:CAALFM_C203940CA
uniprot id: Q5AHG6
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Leads to reduced cell size and to sensitivity to rapamycin, caffeine and sodium dodecyl sulfate. Attenuates the virulence of in a mouse model of systemic candidiasis.
messages: Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway (By similarity). Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO(2) levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.

237561:CAALFM C603960WA
gene id: 237561:CAALFM_C603960WA
uniprot id: A0A1D8PQB4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

237561:CAALFM C104820CA
gene id: 237561:CAALFM_C104820CA
uniprot id: Q59VH3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

237561:CAALFM C503840WA
gene id: 237561:CAALFM_C503840WA
uniprot id: A0A1D8PNT8
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

237561:CAALFM C302780WA
gene id: 237561:CAALFM_C302780WA
uniprot id: Q9HGT6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although this enzyme participates in the selenocysteinyl-tRNA(Sec) biosynthesis pathway in many taxa, this pathway has been shown in PubMed:30742068 to be lost in dikarya.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Homodimer. The tRNA molecule binds across the dimer (By similarity).
messages: cytosol

237561:CAALFM C109730WA
gene id: 237561:CAALFM_C109730WA
uniprot id: Q5APC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAM1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

237561:CAALFM C503080CA
gene id: 237561:CAALFM_C503080CA
uniprot id: A0A1D8PNK9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR01430WA
gene id: 237561:CAALFM_CR01430WA
uniprot id: Q5A9D6
names: Similarity
messages: Belongs to the PIGH family.

237561:CAALFM C501950CA
gene id: 237561:CAALFM_C501950CA
uniprot id: Q59YK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palH/RIM21 family.
messages: Membrane
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

237561:CAALFM C203030WA
gene id: 237561:CAALFM_C203030WA
uniprot id: P52496
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Cell cycle-regulated. Expression peaks in late G1 and during the morphological transition.
messages: Involved in ds DNA break (DSB) repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae.
messages: Nucleus

237561:CAALFM C201330CA
gene id: 237561:CAALFM_C201330CA
uniprot id: O59923
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expression is up-regulated and increases progressively with hyphal development. Expression is inhibited by 2-dodecanol and decreased by allicin and fluconazole.
messages: Interacts with HXK1.
messages: Leads to high frequency phenotypic switching, spontaneous hyphal growth, and decreased replicative lifespan. Shows also oxidatively damaged proteins even distribution between mother and daughter cells during division.
messages: NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching.
messages: Nucleus

237561:CAALFM C603840CA
gene id: 237561:CAALFM_C603840CA
uniprot id: A0A1D8PQ95
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C200100CA
gene id: 237561:CAALFM_C200100CA
uniprot id: Q59L72
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA52 family.
messages: Cell membrane
messages: Expression is induced by fluconazole and repressed by HAP43.

237561:CAALFM C203460CA
gene id: 237561:CAALFM_C203460CA
uniprot id: Q5AHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MGR1 family.
messages: Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
messages: Component of the mitochondrial inner membrane i-AAA protease complex.
messages: Mitochondrion inner membrane

237561:CAALFM C304910CA
gene id: 237561:CAALFM_C304910CA
uniprot id: Q5ANE3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCE102 family.
messages: Cell membrane
messages: Involved in membrane organization. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient (By similarity). Regulates actin organization and subsequent morphogenesis and pathogenesis.
messages: Leads to decreased virulence and forms abnormal hyphae in mice. Shows defects in forming hyphae and invading low concentrations of agar but can invade well in higher agar concentrations.

237561:CAALFM C703030WA
gene id: 237561:CAALFM_C703030WA
uniprot id: G1UAZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP46 family.
messages: Mitochondrion
messages: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

237561:CAALFM C302950CA
gene id: 237561:CAALFM_C302950CA
uniprot id: Q5AEI0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

237561:CAALFM C406890WA
gene id: 237561:CAALFM_C406890WA
uniprot id: A0A1D8PMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

237561:CAALFM C105410CA
gene id: 237561:CAALFM_C105410CA
uniprot id: A0A1D8PDN3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

237561:CAALFM C700400WA
gene id: 237561:CAALFM_C700400WA
uniprot id: A0A1D8PQK5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

237561:CAALFM CR00490WA
gene id: 237561:CAALFM_CR00490WA
uniprot id: A0A1D8PRP6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

237561:CAALFM C108590CA
gene id: 237561:CAALFM_C108590CA
uniprot id: Q92206
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activity is completely abolished by Triton X-100, deoxycholate or Cu(2+), and partially inhibited by thiol reagents, rotenone and antimycin A (PubMed:6378256). The allylamine antimycotic agents naftifine and SF 86-327are potent inhibitors and show apparently non-competitive kinetics with respect to the substrate squalene (PubMed:3877503).
messages: Belongs to the squalene monooxygenase family.
messages: Endoplasmic reticulum membrane
messages: Impairs ergosterol production and leads to increased susceptibility to terbinafine (PubMed:15845783). Leads also to susceptibility to polyenes, nystatin and amphotericin B (PubMed:15845783). Impairs the localization of the membrane-bound transporter CDR1 (PubMed:15845783). Reduces the formation of hyphae (PubMed:15845783).
messages: Microsome membrane
messages: Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:9161422, PubMed:6378256, PubMed:3877503, PubMed:15845783). Erg1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (PubMed:9161422, PubMed:6378256, PubMed:3877503, PubMed:15845783). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27…

237561:CAALFM C107180WA
gene id: 237561:CAALFM_C107180WA
uniprot id: Q59WC0
names: Similarity
messages: Belongs to the CCS1 family.

237561:CAALFM CR02540WA
gene id: 237561:CAALFM_CR02540WA
uniprot id: Q59LV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
messages: Endoplasmic reticulum membrane

237561:CAALFM C109490CA
gene id: 237561:CAALFM_C109490CA
uniprot id: Q5APF2
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.

237561:CAALFM C207450CA
gene id: 237561:CAALFM_C207450CA
uniprot id: A0A1D8PHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

237561:CAALFM C700550CA
gene id: 237561:CAALFM_C700550CA
uniprot id: A0A1D8PQM9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C204490WA
gene id: 237561:CAALFM_C204490WA
uniprot id: A0A1D8PH93
names: Similarity
messages: Belongs to the CCDC124 family.

237561:CAALFM C305730CA
gene id: 237561:CAALFM_C305730CA
uniprot id: A0A1D8PKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

237561:CAALFM CR09760WA
gene id: 237561:CAALFM_CR09760WA
uniprot id: Q5ACU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C501280CA
gene id: 237561:CAALFM_C501280CA
uniprot id: Q5A1Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

237561:CAALFM C600410CA
gene id: 237561:CAALFM_C600410CA
uniprot id: Q59RK1
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

237561:CAALFM C100110WA
gene id: 237561:CAALFM_C100110WA
uniprot id: Q5AB74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

237561:CAALFM C502610CA
gene id: 237561:CAALFM_C502610CA
uniprot id: A0A1D8PNH8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR02200CA
gene id: 237561:CAALFM_CR02200CA
uniprot id: Q59UY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

237561:CAALFM CR09110CA
gene id: 237561:CAALFM_CR09110CA
uniprot id: A0A1D8PTX6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

237561:CAALFM C114110CA
gene id: 237561:CAALFM_C114110CA
uniprot id: A0A1D8PFV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C501060CA
gene id: 237561:CAALFM_C501060CA
uniprot id: Q5A1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C102190WA
gene id: 237561:CAALFM_C102190WA
uniprot id: Q59VY2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

237561:CAALFM C307170CA
gene id: 237561:CAALFM_C307170CA
uniprot id: Q5ADQ8
names: Function
names: Similarity
messages: Belongs to the Rab GDI family.
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

237561:CAALFM C303610WA
gene id: 237561:CAALFM_C303610WA
uniprot id: A0A1D8PJM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM C307610WA
gene id: 237561:CAALFM_C307610WA
uniprot id: Q5ADW3
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the CAND family.
messages: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
messages: No visible phenotype. Cells lacking both RUB1 and CAND1 show defects in morphological, growth and protein degradation, consistent with a reduction in SCF ubiquitin ligase activity.

237561:CAALFM C403750CA
gene id: 237561:CAALFM_C403750CA
uniprot id: A0A1D8PLX1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

237561:CAALFM C502670WA
gene id: 237561:CAALFM_C502670WA
uniprot id: Q5AG95
names: Similarity
messages: Belongs to the cyclin family.

237561:CAALFM C405660CA
gene id: 237561:CAALFM_C405660CA
uniprot id: A0A1D8PMC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

237561:CAALFM C702390WA
gene id: 237561:CAALFM_C702390WA
uniprot id: A0A1D8PR39
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

237561:CAALFM CR04780WA
gene id: 237561:CAALFM_CR04780WA
uniprot id: Q59MZ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

237561:CAALFM C603720WA
gene id: 237561:CAALFM_C603720WA
uniprot id: Q5A8K2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

237561:CAALFM C105790WA
gene id: 237561:CAALFM_C105790WA
uniprot id: A0A1D8PDP5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C101520CA
gene id: 237561:CAALFM_C101520CA
uniprot id: Q5A8Z4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

237561:CAALFM CR01650WA
gene id: 237561:CAALFM_CR01650WA
uniprot id: A0A1D8PS11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

237561:CAALFM C401740WA
gene id: 237561:CAALFM_C401740WA
uniprot id: Q5AMM6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

237561:CAALFM C400070CA
gene id: 237561:CAALFM_C400070CA
uniprot id: A0A1D8PKX5
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

237561:CAALFM C405140CA
gene id: 237561:CAALFM_C405140CA
uniprot id: Q59MN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

237561:CAALFM C700320CA
gene id: 237561:CAALFM_C700320CA
uniprot id: A0A1D8PQK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C301750CA
gene id: 237561:CAALFM_C301750CA
uniprot id: Q5AJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRO1 family.
messages: Cytoplasm
messages: Endosome
messages: Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.

237561:CAALFM CR02330CA
gene id: 237561:CAALFM_CR02330CA
uniprot id: A0A1D8PS73
names: Similarity
messages: Belongs to the MT-A70-like family.

237561:CAALFM C604030WA
gene id: 237561:CAALFM_C604030WA
uniprot id: Q59LF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

237561:CAALFM C108500CA
gene id: 237561:CAALFM_C108500CA
uniprot id: P30575
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

237561:CAALFM C101910WA
gene id: 237561:CAALFM_C101910WA
uniprot id: A0A1D8PCL4
names: Similarity
messages: Belongs to the MYG1 family.

237561:CAALFM CR06750CA
gene id: 237561:CAALFM_CR06750CA
uniprot id: Q59PZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C306240CA
gene id: 237561:CAALFM_C306240CA
uniprot id: A0A1D8PKF3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

237561:CAALFM C505410CA
gene id: 237561:CAALFM_C505410CA
uniprot id: Q5AJY2
names: Similarity
messages: Belongs to the IlvD/Edd family.

237561:CAALFM C100150CA
gene id: 237561:CAALFM_C100150CA
uniprot id: Q9UW13
names: Function
names: Induction
names: Similarity
messages: Belongs to the arrestin family. PalF/RIM8 subfamily.
messages: Induced at acidic pH.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Required for hyphal development.

237561:CAALFM CR01900CA
gene id: 237561:CAALFM_CR01900CA
uniprot id: A0A1D8PS37
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C403230CA
gene id: 237561:CAALFM_C403230CA
uniprot id: A0A1D8PLS1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C304630WA
gene id: 237561:CAALFM_C304630WA
uniprot id: Q5ANI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C406810CA
gene id: 237561:CAALFM_C406810CA
uniprot id: A0A1D8PMN4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

237561:CAALFM C603340CA
gene id: 237561:CAALFM_C603340CA
uniprot id: A0A1D8PQ59
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

237561:CAALFM C203180CA
gene id: 237561:CAALFM_C203180CA
uniprot id: A0A1D8PGT3
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

237561:CAALFM CR04550WA
gene id: 237561:CAALFM_CR04550WA
uniprot id: A0A1D8PSS4
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C114060WA
gene id: 237561:CAALFM_C114060WA
uniprot id: A0A1D8PFV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

237561:CAALFM C304720CA
gene id: 237561:CAALFM_C304720CA
uniprot id: Q5ANH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

237561:CAALFM C303400CA
gene id: 237561:CAALFM_C303400CA
uniprot id: A0A1D8PJW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C500710WA
gene id: 237561:CAALFM_C500710WA
uniprot id: Q59XB0
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: Expression is down-regulated in absence of GOA1.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C702490WA
gene id: 237561:CAALFM_C702490WA
uniprot id: A0A1D8PR43
names: Subcellular Location Annotation
messages: cytosol

237561:CAALFM C403670WA
gene id: 237561:CAALFM_C403670WA
uniprot id: Q59TM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

237561:CAALFM C402760CA
gene id: 237561:CAALFM_C402760CA
uniprot id: P56553
names: Function
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.
messages: Involved in the cell growth regulation.

237561:CAALFM C200520WA
gene id: 237561:CAALFM_C200520WA
uniprot id: Q5ACZ2
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 76 family.
messages: Cell membrane
messages: Induced by caspofungin. Expression is also regulated by SPF1.
messages: Leads to decreased caspofungin sensitivity.
messages: N-mannosylated.
messages: Required for normal synthesis of the cell wall and alkaline pH-induced hypha formation.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C205470WA
gene id: 237561:CAALFM_C205470WA
uniprot id: Q59ZE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

237561:CAALFM C601520WA
gene id: 237561:CAALFM_C601520WA
uniprot id: Q5A4K9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C603060WA
gene id: 237561:CAALFM_C603060WA
uniprot id: Q5ABW2
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C106390WA
gene id: 237561:CAALFM_C106390WA
uniprot id: A0A1D8PDR9
names: Similarity
messages: Belongs to the peptidase C12 family.

237561:CAALFM C109880CA
gene id: 237561:CAALFM_C109880CA
uniprot id: Q5APB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

237561:CAALFM C603250WA
gene id: 237561:CAALFM_C603250WA
uniprot id: Q5ABT8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
messages: Expression in regulated by TSA1 and repressed in rat catheter biofilm.
messages: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
messages: Membrane

237561:CAALFM CR05440WA
gene id: 237561:CAALFM_CR05440WA
uniprot id: Q59K86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

237561:CAALFM C402970CA
gene id: 237561:CAALFM_C402970CA
uniprot id: A0A1D8PLP8
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

237561:CAALFM C105910WA
gene id: 237561:CAALFM_C105910WA
uniprot id: Q5AA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIP5 family.
messages: Cytoplasm
messages: May negatively regulate the SNF1 kinase.

237561:CAALFM C304350CA
gene id: 237561:CAALFM_C304350CA
uniprot id: A0A1D8PK06
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C206250CA
gene id: 237561:CAALFM_C206250CA
uniprot id: Q59P49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

237561:CAALFM C109290CA
gene id: 237561:CAALFM_C109290CA
uniprot id: A0A1D8PEI6
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion

237561:CAALFM CR05910WA
gene id: 237561:CAALFM_CR05910WA
uniprot id: Q59PU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

237561:CAALFM C402690WA
gene id: 237561:CAALFM_C402690WA
uniprot id: A0A1D8PLN0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

237561:CAALFM C104880CA
gene id: 237561:CAALFM_C104880CA
uniprot id: Q59VH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

237561:CAALFM C405380CA
gene id: 237561:CAALFM_C405380CA
uniprot id: A0A1D8PMC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C407240WA
gene id: 237561:CAALFM_C407240WA
uniprot id: A0A1D8PMT7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C202490CA
gene id: 237561:CAALFM_C202490CA
uniprot id: A0A1D8PGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

237561:CAALFM C206390CA
gene id: 237561:CAALFM_C206390CA
uniprot id: Q59Q46
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Also inhibited by ADP.

237561:CAALFM C107590CA
gene id: 237561:CAALFM_C107590CA
uniprot id: A0A1D8PE70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

237561:CAALFM C106790CA
gene id: 237561:CAALFM_C106790CA
uniprot id: Q5AAS9
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

237561:CAALFM CR01120CA
gene id: 237561:CAALFM_CR01120CA
uniprot id: Q5A886
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

237561:CAALFM C106660WA
gene id: 237561:CAALFM_C106660WA
uniprot id: A0A1D8PDV1
names: Similarity
messages: Belongs to the IFRD family.

237561:CAALFM C200260CA
gene id: 237561:CAALFM_C200260CA
uniprot id: A0A1D8PG14
names: Similarity
messages: Belongs to the cytidylyltransferase family.

237561:CAALFM C202210CA
gene id: 237561:CAALFM_C202210CA
uniprot id: A0A1D8PGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM C204850CA
gene id: 237561:CAALFM_C204850CA
uniprot id: A0A1D8PH89
names: Similarity
messages: Belongs to the SH3YL1 family.

237561:CAALFM C406430CA
gene id: 237561:CAALFM_C406430CA
uniprot id: A0A1D8PML6
names: Similarity
messages: Belongs to the AFG1 ATPase family.

237561:CAALFM CR06730WA
gene id: 237561:CAALFM_CR06730WA
uniprot id: Q59PZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
messages: Homodimer.
messages: Preautophagosomal structure
messages: The GxGxxG motif is important for the function, possibly through binding with ATP.

237561:CAALFM C305200WA
gene id: 237561:CAALFM_C305200WA
uniprot id: A0A1D8PK61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS19A is required for proper maturation of the small (40S) ribosomal subunit (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C209530WA
gene id: 237561:CAALFM_C209530WA
uniprot id: G1UBC2
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA18 family.
messages: Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence.
messages: Expressed in white cells. Transcription is regulated by the transcription factor EFG1 and up-regulated by alpha-pheromone, by host serum, in biofilms, and in high iron conditions. Repressed by BCR1 in a/a biofilms.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The N-terminal domain mediates haploid invasive growth and yeast cell-cell adhesion.
messages: The regions containing tandem repeats are required to project the N-terminal region into the extracellular environment and to mediate adhesion to polystyrene and to host cells. In allele CaO19.8979, the N-terminal tandem repeat region is expended and contains up to 90 repeats and the C-terminal tandem repeat region has one more repeat.
messages: cell wall

237561:CAALFM C405030CA
gene id: 237561:CAALFM_C405030CA
uniprot id: A0A1D8PM87
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

237561:CAALFM C307480WA
gene id: 237561:CAALFM_C307480WA
uniprot id: Q5ADV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

237561:CAALFM C401490WA
gene id: 237561:CAALFM_C401490WA
uniprot id: Q5AML1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

237561:CAALFM CR07290WA
gene id: 237561:CAALFM_CR07290WA
uniprot id: A0A1D8PTG2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504800WA
gene id: 237561:CAALFM_C504800WA
uniprot id: Q5AK54
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.
messages: Extracellular glycosidase which plays an important role in fungal pathogenesis. Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells.
messages: Leads to increased susceptibility to cell wall-perturbing agents.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Unlike CRH11, CRH12 is down-regulated during cell wall regeneration. Also regulated by NRG1, TUP1, and RIM101.
messages: cell wall

237561:CAALFM C205720CA
gene id: 237561:CAALFM_C205720CA
uniprot id: A0A1D8PHG1
names: Similarity
messages: Belongs to the OSBP family.

237561:CAALFM C300840CA
gene id: 237561:CAALFM_C300840CA
uniprot id: Q59LP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

237561:CAALFM CR00860CA
gene id: 237561:CAALFM_CR00860CA
uniprot id: Q5A860
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization (By similarity).
messages: cytoskeleton

237561:CAALFM C305460WA
gene id: 237561:CAALFM_C305460WA
uniprot id: A0A1D8PKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C501170WA
gene id: 237561:CAALFM_C501170WA
uniprot id: Q5A1U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.
messages: The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).

237561:CAALFM CR10600CA
gene id: 237561:CAALFM_CR10600CA
uniprot id: A0A1D8PU83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

237561:CAALFM C400400WA
gene id: 237561:CAALFM_C400400WA
uniprot id: Q59UQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

237561:CAALFM C405210WA
gene id: 237561:CAALFM_C405210WA
uniprot id: Q59RA2
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalytic activity is higher with Mg(2+).
messages: Catalyzes the synthesis of phosphatidylinositol (PtdIns) (PubMed:8740418). Required for proper membrane dynamics and cell wall integrity (PubMed:35227874).
messages: Endoplasmic reticulum membrane
messages: Growth defect.
messages: Inhibited by calcium and zinc ions (PubMed:8740418). Inhibited by nucleoside triphosphates and diphosphates (PubMed:8740418).

237561:CAALFM CR08920WA
gene id: 237561:CAALFM_CR08920WA
uniprot id: A0A1D8PTU4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

237561:CAALFM C400490WA
gene id: 237561:CAALFM_C400490WA
uniprot id: A0A1D8PL26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).

237561:CAALFM C113730CA
gene id: 237561:CAALFM_C113730CA
uniprot id: Q5AKW7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

237561:CAALFM C105940WA
gene id: 237561:CAALFM_C105940WA
uniprot id: A0A1D8PDP9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C103240WA
gene id: 237561:CAALFM_C103240WA
uniprot id: A0A1D8PD02
names: Similarity
messages: Belongs to the UPF0047 family.

237561:CAALFM C307630CA
gene id: 237561:CAALFM_C307630CA
uniprot id: Q5ADW5
names: Similarity
messages: Belongs to the SPT2 family.

237561:CAALFM CR06340CA
gene id: 237561:CAALFM_CR06340CA
uniprot id: P83780
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Homodimer.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.

237561:CAALFM CR09920WA
gene id: 237561:CAALFM_CR09920WA
uniprot id: A0A1D8PU37
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C107950CA
gene id: 237561:CAALFM_C107950CA
uniprot id: Q5A796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

237561:CAALFM C300890CA
gene id: 237561:CAALFM_C300890CA
uniprot id: A0A1D8PJ34
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

237561:CAALFM C600150WA
gene id: 237561:CAALFM_C600150WA
uniprot id: A0A1D8PPB1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM CR03050CA
gene id: 237561:CAALFM_CR03050CA
uniprot id: A0A1D8PSC7
names: Similarity
messages: Belongs to the ERT1/acuK family.

237561:CAALFM C105820CA
gene id: 237561:CAALFM_C105820CA
uniprot id: Q5AA15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

237561:CAALFM C501520CA
gene id: 237561:CAALFM_C501520CA
uniprot id: Q59NQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

237561:CAALFM CR06740WA
gene id: 237561:CAALFM_CR06740WA
uniprot id: Q59PZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

237561:CAALFM C406230CA
gene id: 237561:CAALFM_C406230CA
uniprot id: Q5A1A4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

237561:CAALFM C205250CA
gene id: 237561:CAALFM_C205250CA
uniprot id: A0A1D8PHC9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

237561:CAALFM C302960CA
gene id: 237561:CAALFM_C302960CA
uniprot id: A0A1D8PJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

237561:CAALFM C304660CA
gene id: 237561:CAALFM_C304660CA
uniprot id: Q5ANH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C305520CA
gene id: 237561:CAALFM_C305520CA
uniprot id: A0A1D8PKC9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

237561:CAALFM C110120CA
gene id: 237561:CAALFM_C110120CA
uniprot id: Q5AP83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

237561:CAALFM C302930WA
gene id: 237561:CAALFM_C302930WA
uniprot id: Q5AEI2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG10 family.
messages: E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).
messages: Expression is decreased upon fluphenazine treatment.
messages: Forms homooligomers.
messages: Preautophagosomal structure membrane

237561:CAALFM C103560CA
gene id: 237561:CAALFM_C103560CA
uniprot id: Q5AHZ3
names: Similarity
messages: Belongs to the TFIIB family.

237561:CAALFM C704150WA
gene id: 237561:CAALFM_C704150WA
uniprot id: A0A1D8PRI9
names: Similarity
messages: Belongs to the Tango6 family.

237561:CAALFM C101000CA
gene id: 237561:CAALFM_C101000CA
uniprot id: Q5A945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

237561:CAALFM C110750CA
gene id: 237561:CAALFM_C110750CA
uniprot id: A0A1D8PEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

237561:CAALFM C101610CA
gene id: 237561:CAALFM_C101610CA
uniprot id: A0A1D8PCI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C603110CA
gene id: 237561:CAALFM_C603110CA
uniprot id: Q5ABV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ASA1 family.
messages: Component of the ASTRA chromatin remodeling machinery complex.
messages: Component of the ASTRA complex involved in chromatin remodeling.
messages: Nucleus

237561:CAALFM C403050CA
gene id: 237561:CAALFM_C403050CA
uniprot id: A0A1D8PLQ3
names: Similarity
messages: Belongs to the peptidase M20A family.

237561:CAALFM C113870WA
gene id: 237561:CAALFM_C113870WA
uniprot id: Q9Y872
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfate adenylyltransferase family.
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Homohexamer. Dimer of trimers.
messages: The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

237561:CAALFM C402780WA
gene id: 237561:CAALFM_C402780WA
uniprot id: A0A1D8PLN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

237561:CAALFM C402390WA
gene id: 237561:CAALFM_C402390WA
uniprot id: Q5AF41
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HWP1 family.
messages: Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation.
messages: Induced during cell well regeneration, by fluconazole, and in high iron conditions. Expression is also induced by TBF1 and repressed by SSK1, and CYR1 or RAS1.
messages: Leads to an altered cell wall structure with a less electron dense inner layer of the cell wall, and a disorganized outer layer.
messages: Membrane
messages: N- and O-glycosylated.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C203100WA
gene id: 237561:CAALFM_C203100WA
uniprot id: Q5A0M4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Has antigenic properties.

237561:CAALFM C600960WA
gene id: 237561:CAALFM_C600960WA
uniprot id: A0A1D8PPI5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is induced during phagocytosis by host macrophages (PubMed:15470236). Expression is also induced during biofilm development (PubMed:19527170, PubMed:21414038, PubMed:22265407).
messages: High-affinity permease for basic amino acids arginine, lysine and histidine (PubMed:8299168, PubMed:9180275).

237561:CAALFM C305170WA
gene id: 237561:CAALFM_C305170WA
uniprot id: Q5ANB1
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced by HAP43 under low iron conditions.
messages: Nucleus
messages: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.

237561:CAALFM CR03040CA
gene id: 237561:CAALFM_CR03040CA
uniprot id: A0A1D8PSC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C302180CA
gene id: 237561:CAALFM_C302180CA
uniprot id: A0A1D8PJD2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

237561:CAALFM C110230CA
gene id: 237561:CAALFM_C110230CA
uniprot id: A0A1D8PES9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C700290CA
gene id: 237561:CAALFM_C700290CA
uniprot id: A0A1D8PQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR02640WA
gene id: 237561:CAALFM_CR02640WA
uniprot id: Q5A220
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is regulated by WOR1.
messages: Leads to constitutive hyphal growth and avirulence in a mouse model.
messages: Nucleus
messages: Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5.

237561:CAALFM CR06420WA
gene id: 237561:CAALFM_CR06420WA
uniprot id: Q59U06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

237561:CAALFM C402170CA
gene id: 237561:CAALFM_C402170CA
uniprot id: Q5AMS2
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

237561:CAALFM C201240CA
gene id: 237561:CAALFM_C201240CA
uniprot id: Q5AD67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus

237561:CAALFM C503580CA
gene id: 237561:CAALFM_C503580CA
uniprot id: A0A1D8PNS7
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C307050WA
gene id: 237561:CAALFM_C307050WA
uniprot id: Q5ADP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
messages: P-body
messages: nucleoplasm

237561:CAALFM C110300WA
gene id: 237561:CAALFM_C110300WA
uniprot id: Q5APQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).

237561:CAALFM C403100WA
gene id: 237561:CAALFM_C403100WA
uniprot id: A0A1D8PLR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
messages: Vacuole lumen

237561:CAALFM C704040CA
gene id: 237561:CAALFM_C704040CA
uniprot id: A0A1D8PRI0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

237561:CAALFM C102430CA
gene id: 237561:CAALFM_C102430CA
uniprot id: A0A1D8PCQ3
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

237561:CAALFM C304680WA
gene id: 237561:CAALFM_C304680WA
uniprot id: Q5ANH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

237561:CAALFM C100710CA
gene id: 237561:CAALFM_C100710CA
uniprot id: A0A1D8PC97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

237561:CAALFM C103380WA
gene id: 237561:CAALFM_C103380WA
uniprot id: Q5AI14
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

237561:CAALFM C104090CA
gene id: 237561:CAALFM_C104090CA
uniprot id: A0A1D8PD68
names: Similarity
messages: Belongs to the cyclin family.

237561:CAALFM C406060WA
gene id: 237561:CAALFM_C406060WA
uniprot id: A0A1D8PMH5
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

237561:CAALFM C603520CA
gene id: 237561:CAALFM_C603520CA
uniprot id: A0A1D8PQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

237561:CAALFM C108300WA
gene id: 237561:CAALFM_C108300WA
uniprot id: A0A1D8PE87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C108480CA
gene id: 237561:CAALFM_C108480CA
uniprot id: Q59QC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane (By similarity). Involved in vacuolar trafficking and contributes to hyphal growth and pathogenesis.

237561:CAALFM C604250WA
gene id: 237561:CAALFM_C604250WA
uniprot id: A0A1D8PQD5
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

237561:CAALFM C601500CA
gene id: 237561:CAALFM_C601500CA
uniprot id: Q5A4K7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate.

237561:CAALFM C601060CA
gene id: 237561:CAALFM_C601060CA
uniprot id: Q59WU0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is negatively regulated by the transcriptional repressors NRG1 and TUP1 (PubMed:11532938, PubMed:11737641). Expression is also regulated by SSN6 (PubMed:15814841). Expression is repressed by HAP43 (PubMed:21592964). Expression is induced by antifungal agents caspofungin and flucytosine (PubMed:15917516). Finally, expression is also induced during biofilm development (PubMed:19527170, PubMed:22265407).
messages: Probable permease for arginine and lysine.

237561:CAALFM C603900WA
gene id: 237561:CAALFM_C603900WA
uniprot id: A0A1D8PQA2
names: Subcellular Location Annotation
messages: nuclear pore complex

237561:CAALFM C303790WA
gene id: 237561:CAALFM_C303790WA
uniprot id: Q59ST1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

237561:CAALFM CR06440CA
gene id: 237561:CAALFM_CR06440CA
uniprot id: Q59U10
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Expression is under the positive control of the hyphal regulator TEC1 and repressed by TUP1 (PubMed:15814840, PubMed:15964282). Also induced by acetic acid-stress in a MNL1-dependent manner (PubMed:18653474).
messages: Implanted medical devices, such as venous catheters, are a serious risk factor for C.albicans infection since they are substrates for the formation of biofilms, which in turn serve as reservoirs of cells to continually seed an infection.
messages: Interacts with CBK1.
messages: Nucleus
messages: Phosphorylated at Thr-191 and Ser-556 by CBK1. Phosphorylation by CBK1 is required for ALS1 and ALS3 expression, adherence, and biofilm formation.
messages: Produces poor biofilms and decreases infection on rat denture models (PubMed:20605982, PubMed:20705667). Increases phagocytosis of the fungus by host cells in presence of estrogen (PubMed:34986357). Decreases expression of GPD2 (PubMed:34986357).
messages: Transcription factor which acts as a master regulator of biofilm formation (PubMed:15964282, PubMed:17030992, PubMed:16839200, PubMed:20223293, PubMed:19959578, PubMed:20705667, PubMed:21829325, PubMed:21283544, PubMed:21407800, PubMed:22145027, PubMed:22265407, PubMed:22882910, PubMed:22589718). Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis (PubMed:20705667, PubMed:21283544, PubMed:21407800, PubMed:22544909, PubMed:22265407). Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 and HYR1 (PubMed:16839200, PubMed:17277173, PubMed:19197361, PubMed:20415594, PubMed:22145027, PubMed:22544909, PubMed:22589718). Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation (PubMed:20223293, PubMed:21407800, PubMed:22359502).

237561:CAALFM C701250WA
gene id: 237561:CAALFM_C701250WA
uniprot id: P83774
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Causes defects in hyphal development under hypha-inducing conditions and attenuates virulence in a mouse model of systemic infection.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome (By similarity). Involved in the negative regulation of translation of a specific subset of proteins (By similarity). Plays a role in morphogenesis and pathogenesis (PubMed:20929924).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

237561:CAALFM C102100WA
gene id: 237561:CAALFM_C102100WA
uniprot id: A0A1D8PCQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

237561:CAALFM C601850WA
gene id: 237561:CAALFM_C601850WA
uniprot id: A0A1D8PPR9
names: Similarity
messages: Belongs to the VPS72/YL1 family.

237561:CAALFM C600430CA
gene id: 237561:CAALFM_C600430CA
uniprot id: Q59RK0
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

237561:CAALFM C306570CA
gene id: 237561:CAALFM_C306570CA
uniprot id: A0A1D8PKM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

237561:CAALFM C400390WA
gene id: 237561:CAALFM_C400390WA
uniprot id: Q59UQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

237561:CAALFM C305130CA
gene id: 237561:CAALFM_C305130CA
uniprot id: Q5ANB7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus

237561:CAALFM C208840WA
gene id: 237561:CAALFM_C208840WA
uniprot id: Q59Y64
names: Similarity
messages: Belongs to the TRM112 family.

237561:CAALFM C406870WA
gene id: 237561:CAALFM_C406870WA
uniprot id: A0A1D8PMQ4
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM CR03540WA
gene id: 237561:CAALFM_CR03540WA
uniprot id: A0A1D8PSH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

237561:CAALFM CR05560WA
gene id: 237561:CAALFM_CR05560WA
uniprot id: Q59M53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

237561:CAALFM C302920WA
gene id: 237561:CAALFM_C302920WA
uniprot id: Q5AEI3
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

237561:CAALFM C307710WA
gene id: 237561:CAALFM_C307710WA
uniprot id: Q5ADX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

237561:CAALFM C306310CA
gene id: 237561:CAALFM_C306310CA
uniprot id: Q5A310
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
messages: Component of the ISW2 complex.
messages: Expression is induced by the HAP43 transcription factor and repressed in response to high doses of peroxide stress.
messages: Nucleus

237561:CAALFM C104240CA
gene id: 237561:CAALFM_C104240CA
uniprot id: Q59VN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

237561:CAALFM C300400CA
gene id: 237561:CAALFM_C300400CA
uniprot id: A0A1D8PIX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C209700WA
gene id: 237561:CAALFM_C209700WA
uniprot id: A0A1D8PIJ0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR04920WA
gene id: 237561:CAALFM_CR04920WA
uniprot id: Q59KC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
messages: Mitochondrion inner membrane

237561:CAALFM C100570CA
gene id: 237561:CAALFM_C100570CA
uniprot id: A0A1D8PC90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

237561:CAALFM C109470CA
gene id: 237561:CAALFM_C109470CA
uniprot id: Q5APF5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

237561:CAALFM C601130WA
gene id: 237561:CAALFM_C601130WA
uniprot id: A0A1D8PPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C105850WA
gene id: 237561:CAALFM_C105850WA
uniprot id: A0A1D8PDM8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C602470WA
gene id: 237561:CAALFM_C602470WA
uniprot id: A0A1D8PPX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

237561:CAALFM C505260WA
gene id: 237561:CAALFM_C505260WA
uniprot id: Q5AK01
names: Similarity
messages: Belongs to the PPP4R2 family.

237561:CAALFM C402130WA
gene id: 237561:CAALFM_C402130WA
uniprot id: Q5AMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR02780WA
gene id: 237561:CAALFM_CR02780WA
uniprot id: Q5A207
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

237561:CAALFM C104540CA
gene id: 237561:CAALFM_C104540CA
uniprot id: A0A1D8PDC9
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

237561:CAALFM C105030CA
gene id: 237561:CAALFM_C105030CA
uniprot id: Q59MA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).

237561:CAALFM C504110WA
gene id: 237561:CAALFM_C504110WA
uniprot id: A0A1D8PNW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

237561:CAALFM C112310CA
gene id: 237561:CAALFM_C112310CA
uniprot id: A0A1D8PFE1
names: Similarity
messages: Belongs to the BRX1 family.

237561:CAALFM CR00400CA
gene id: 237561:CAALFM_CR00400CA
uniprot id: Q5AAJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

237561:CAALFM C304500CA
gene id: 237561:CAALFM_C304500CA
uniprot id: A0A1D8PK40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL19A may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors (By similarity).
messages: Cytoplasm

237561:CAALFM C209970CA
gene id: 237561:CAALFM_C209970CA
uniprot id: Q59YH1
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

237561:CAALFM C402290WA
gene id: 237561:CAALFM_C402290WA
uniprot id: P0CH67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

237561:CAALFM C100430WA
gene id: 237561:CAALFM_C100430WA
uniprot id: Q5ABA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the PI(3,5)P2 regulatory complex.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.
messages: The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
messages: Vacuole membrane

237561:CAALFM C101550WA
gene id: 237561:CAALFM_C101550WA
uniprot id: Q5A8Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
messages: Component of the retromer complex.

237561:CAALFM C103160CA
gene id: 237561:CAALFM_C103160CA
uniprot id: Q5AI44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

237561:CAALFM CR09180WA
gene id: 237561:CAALFM_CR09180WA
uniprot id: Q5A3Z5
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Cysteine dioxygenase involved in sulfite formation from cysteine. Plays an important role in filamentous growth and virulence.
messages: Displays reduced hyphae formation in the presence of cysteine and leads to attenuated virulence.
messages: Expression is under the control of the ZCF2 transcription factor and is regulated upon white-opaque switching. Transcription is also up-regulated in both intermediate and mature biofilms.
messages: The thioether cross-link between Cys-157 and Tyr-221 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

237561:CAALFM C209320CA
gene id: 237561:CAALFM_C209320CA
uniprot id: Q59X38
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). Required for the transition from hyphal to yeast growth.
messages: Expressed under both yeast and hyphal conditions of growth.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM C504510WA
gene id: 237561:CAALFM_C504510WA
uniprot id: A0A1D8PNZ7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDE1 family.
messages: Cytoplasm
messages: Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876). Induced during early phase of biofilm formation (PubMed:16151249).
messages: Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline (PubMed:24114876). The choline is used for phosphatidyl-choline synthesis (PubMed:24114876). Required for utilization of glycerophosphocholine as phosphate source (PubMed:24114876). C.albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis (PubMed:24114876).
messages: Results in altered glycerophosphocholine catabolism (PubMed:24114876). Leads to hypersensitivity to 5-fluorouracil (5-FU) (PubMed:17604452).

237561:CAALFM C501570CA
gene id: 237561:CAALFM_C501570CA
uniprot id: A0A1D8PN71
names: Similarity
messages: Belongs to the lysophospholipase family.

237561:CAALFM C402280WA
gene id: 237561:CAALFM_C402280WA
uniprot id: A0A1D8PLI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Isopentenyl-diphosphate delta-isomerase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). IDI1 catalyzes the 1,3-allylic rearrangement of isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

237561:CAALFM C101330CA
gene id: 237561:CAALFM_C101330CA
uniprot id: P0CY19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

237561:CAALFM C202510WA
gene id: 237561:CAALFM_C202510WA
uniprot id: Q5ALK3
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

237561:CAALFM C201430WA
gene id: 237561:CAALFM_C201430WA
uniprot id: Q5ALX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

237561:CAALFM C504490CA
gene id: 237561:CAALFM_C504490CA
uniprot id: A0A1D8PP00
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

237561:CAALFM C200450CA
gene id: 237561:CAALFM_C200450CA
uniprot id: Q5ACY4
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

237561:CAALFM C402550CA
gene id: 237561:CAALFM_C402550CA
uniprot id: Q5AF62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

237561:CAALFM C404410CA
gene id: 237561:CAALFM_C404410CA
uniprot id: Q5A644
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

237561:CAALFM CR03620CA
gene id: 237561:CAALFM_CR03620CA
uniprot id: A0A1D8PSJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.

237561:CAALFM C302610CA
gene id: 237561:CAALFM_C302610CA
uniprot id: Q5AF03
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C56 family. HSP31-like subfamily.
messages: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. Selective for MG, does not use glyoxal as substrate. Plays a role in detoxifying endogenously produced MG, particularly when glycerol is the principal carbon source (PubMed:24302734). Important for viability in stationary phase (By similarity).
messages: Has a 3- to 5-fold increase in levels of intracellular methylglyoxal compared with wild-type cells grown in the same media.
messages: Monomer.

237561:CAALFM C306650CA
gene id: 237561:CAALFM_C306650CA
uniprot id: A0A1D8PKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

237561:CAALFM C303830WA
gene id: 237561:CAALFM_C303830WA
uniprot id: Q59ST6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

237561:CAALFM C107340WA
gene id: 237561:CAALFM_C107340WA
uniprot id: A0A1D8PE13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

237561:CAALFM C300930WA
gene id: 237561:CAALFM_C300930WA
uniprot id: A0A1D8PJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C208680WA
gene id: 237561:CAALFM_C208680WA
uniprot id: Q59Y41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
messages: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) (By similarity).
messages: Nucleus

237561:CAALFM CR00780CA
gene id: 237561:CAALFM_CR00780CA
uniprot id: Q5A850
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

237561:CAALFM C307400WA
gene id: 237561:CAALFM_C307400WA
uniprot id: Q5ADU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

237561:CAALFM C702800WA
gene id: 237561:CAALFM_C702800WA
uniprot id: Q5A599
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expression is increased in opaque cells.
messages: Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Required for hyphal formation and virulence. Plays a role in fungicides sensitivity, probably through the positive regulation of the HOG1-signaling pathway. Presumed to mediate phosphotransfer to the HOG1 MAP kinase pathway during oxidative and perhaps osmotic stress.
messages: Impairs the hyphal formation and attenuates the virulence in a mouse systemic candidiasis model.
messages: The HAMP domains are critical for the sensitivity to fungicides such as fludioxonil, as well as for activation of HOG1.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-510 (H1) in the histidine kinase domain (transmitter domain) to Asp-924 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two NIK1 molecules, rather than intramolecularly (By similarity).

237561:CAALFM C105930CA
gene id: 237561:CAALFM_C105930CA
uniprot id: A0A1D8PDN2
names: Similarity
messages: Belongs to the peptidase M20A family.

237561:CAALFM C112830CA
gene id: 237561:CAALFM_C112830CA
uniprot id: A0A1D8PFH9
names: Similarity
messages: Belongs to the WD repeat WDR48 family.

237561:CAALFM C110760WA
gene id: 237561:CAALFM_C110760WA
uniprot id: Q59WF8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

237561:CAALFM C300660WA
gene id: 237561:CAALFM_C300660WA
uniprot id: Q5A7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the RSE1 family.
messages: Involved in pre-mRNA splicing and cell cycle control.
messages: Nucleus

237561:CAALFM C602260CA
gene id: 237561:CAALFM_C602260CA
uniprot id: A0A1D8PPV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

237561:CAALFM C400330CA
gene id: 237561:CAALFM_C400330CA
uniprot id: A0A1D8PL02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

237561:CAALFM C401900CA
gene id: 237561:CAALFM_C401900CA
uniprot id: Q5AMP4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

237561:CAALFM C204930CA
gene id: 237561:CAALFM_C204930CA
uniprot id: Q9Y7W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Nucleus
messages: Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice.

237561:CAALFM C113200CA
gene id: 237561:CAALFM_C113200CA
uniprot id: Q5AL29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
messages: Belongs to the REXO1/REXO3 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C112440WA
gene id: 237561:CAALFM_C112440WA
uniprot id: Q5A3Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).
messages: Nucleus

237561:CAALFM CR05800CA
gene id: 237561:CAALFM_CR05800CA
uniprot id: Q59PT4
names: Function
names: Similarity
messages: Belongs to the LCL2 family.
messages: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.

237561:CAALFM C602380WA
gene id: 237561:CAALFM_C602380WA
uniprot id: Q59S59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity).
messages: Belongs to the DEAD box helicase family. MRH4 subfamily.
messages: Mitochondrion
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C700620WA
gene id: 237561:CAALFM_C700620WA
uniprot id: A0A1D8PQL8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

237561:CAALFM C200700WA
gene id: 237561:CAALFM_C200700WA
uniprot id: Q5AD10
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

237561:CAALFM C703620CA
gene id: 237561:CAALFM_C703620CA
uniprot id: Q59R26
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C400670WA
gene id: 237561:CAALFM_C400670WA
uniprot id: A0A1D8PL65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

237561:CAALFM C305360CA
gene id: 237561:CAALFM_C305360CA
uniprot id: Q59YV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

237561:CAALFM C405240CA
gene id: 237561:CAALFM_C405240CA
uniprot id: Q59R99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

237561:CAALFM CR10020CA
gene id: 237561:CAALFM_CR10020CA
uniprot id: Q5ACR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with missfolded ER lumenal proteins.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).

237561:CAALFM C405450CA
gene id: 237561:CAALFM_C405450CA
uniprot id: Q59P03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane
messages: Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.

237561:CAALFM CR07670WA
gene id: 237561:CAALFM_CR07670WA
uniprot id: Q59N44
names: Similarity
messages: Belongs to the NifU family.

237561:CAALFM C209280CA
gene id: 237561:CAALFM_C209280CA
uniprot id: Q59X41
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR01370CA
gene id: 237561:CAALFM_CR01370CA
uniprot id: A0A1D8PRY0
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

237561:CAALFM C301910CA
gene id: 237561:CAALFM_C301910CA
uniprot id: A0A1D8PJB8
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

237561:CAALFM C113660WA
gene id: 237561:CAALFM_C113660WA
uniprot id: Q5AKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

237561:CAALFM C204860WA
gene id: 237561:CAALFM_C204860WA
uniprot id: Q59KL6
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced by HAP43 and during biofilm formation.
messages: Nucleus
messages: Transcription factor required for transcription of 5S rRNA by RNA polymerase III.

237561:CAALFM C400310CA
gene id: 237561:CAALFM_C400310CA
uniprot id: Q59UR2
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

237561:CAALFM C200380CA
gene id: 237561:CAALFM_C200380CA
uniprot id: Q5ACX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

237561:CAALFM C108420WA
gene id: 237561:CAALFM_C108420WA
uniprot id: A0A1D8PEB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

237561:CAALFM C403090WA
gene id: 237561:CAALFM_C403090WA
uniprot id: Q5AFC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

237561:CAALFM C504660CA
gene id: 237561:CAALFM_C504660CA
uniprot id: Q5AK69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C405290WA
gene id: 237561:CAALFM_C405290WA
uniprot id: A0A1D8PMB0
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

237561:CAALFM C307440WA
gene id: 237561:CAALFM_C307440WA
uniprot id: Q9P940
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Critical for growth.
messages: Cytoplasm
messages: Has antigenic properties.
messages: Homodimer.

237561:CAALFM C109840CA
gene id: 237561:CAALFM_C109840CA
uniprot id: Q5APB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
messages: Nucleus

237561:CAALFM C603770CA
gene id: 237561:CAALFM_C603770CA
uniprot id: Q5A8J7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C600880WA
gene id: 237561:CAALFM_C600880WA
uniprot id: Q59WW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

237561:CAALFM C206850WA
gene id: 237561:CAALFM_C206850WA
uniprot id: A0A1D8PHS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX9 family.
messages: Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.
messages: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.
messages: nucleolus

237561:CAALFM C407120CA
gene id: 237561:CAALFM_C407120CA
uniprot id: Q5A102
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

237561:CAALFM C305410WA
gene id: 237561:CAALFM_C305410WA
uniprot id: A0A1D8PK91
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C402410CA
gene id: 237561:CAALFM_C402410CA
uniprot id: Q5AF44
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

237561:CAALFM C109800CA
gene id: 237561:CAALFM_C109800CA
uniprot id: Q5APC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.

237561:CAALFM C106060CA
gene id: 237561:CAALFM_C106060CA
uniprot id: A0A1D8PDT0
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

237561:CAALFM CR06050WA
gene id: 237561:CAALFM_CR06050WA
uniprot id: P43063
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (By similarity). May drive the G1-S transition (PubMed:7830719). Plays a role in mitotic exit (PubMed:22090345). Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes (PubMed:16710830, PubMed:11809828, PubMed:15659158). Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth (PubMed:15071502, PubMed:17765684, PubMed:18923418, PubMed:22787279). The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1 (PubMed:18923418). The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics (PubMed:22787279). The CDC28-CCN1 complex phosphorylates CDC11 and SEC2 upon induction of filamentous growth (PubMed:17765684). The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth (PubMed:20639857). Moreover, the CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension (PubMed:17673907). CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth (PubMed:19528234). Additional substrates for CDC28 are RFA2 in G1-phase; MOB2, which is required for the maintenance of polarisome components and for inhibition of cell separation in hyphae; and GIN4 to regulate its association to SEP7 and subsequent septin ring assembly (PubMed:23140133, PubMed:22366454, PubMed:21593210).
messages: Expression is increased during exponential growth and repressed by the antifungal drug plagiochin E (PLE).
messages: Forms several complexes with cyclins CCN1, CLB2, CLN3, and HGC1. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction. Interacts with IQG1, RFA2, and HSP90.
messages: Phosphorylated at Tyr-18 by SWE1 in a cell cycle-dependent manner. Yeast-form and hyphal cells display similar dynamics of phosphorylation and dephosphorylation of Tyr-18. Tyr-18 phosphorylation leads to inhibition of CDC28 kinase activity.
messages: Phosphorylation at Thr-17 or Tyr-18 inactivates the enzyme, while phosphorylation at Thr-166 activates it.

237561:CAALFM C407180WA
gene id: 237561:CAALFM_C407180WA
uniprot id: Q5A109
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ubiquitin is encoded by several different genes. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 3 exact head to tail repeats of ubiquitin.

237561:CAALFM C600350WA
gene id: 237561:CAALFM_C600350WA
uniprot id: A0A1D8PPB9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

237561:CAALFM C210190CA
gene id: 237561:CAALFM_C210190CA
uniprot id: Q59XY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Putative tyrosine-protein phosphatase required for protection against superoxide stress.

237561:CAALFM C206880CA
gene id: 237561:CAALFM_C206880CA
uniprot id: Q59Z57
names: Similarity
messages: Belongs to the peptidase S8 family.

237561:CAALFM C103250CA
gene id: 237561:CAALFM_C103250CA
uniprot id: Q5AI35
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR09880WA
gene id: 237561:CAALFM_CR09880WA
uniprot id: G1UB67
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Leads to yeast-locked cells.
messages: Nucleus
messages: Regulated by EFG1, NRG1, and TUP1. Expression is increased with increasing cell density and during host infection. Expression is repressed by linalool.
messages: Transcriptional regulator involved in extension of germ tubes into elongated hyphae and maintenance of filamentous growth. Regulates expression of UME6. Acts in a pathway that regulates maintenance of hyphal growth by repressing hyphal-to-yeast transition and allows dissemination within host epithelial tissues. Dispensable for invasion into both host oral epithelial cells and enterocytes, but required for epithelial damage.

237561:CAALFM CR03890WA
gene id: 237561:CAALFM_CR03890WA
uniprot id: Q5A6T8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced in opaque cells and biofilm, and is regulated by WOR1.
messages: Nucleus
messages: Stabilizes opaque cells at higher temperatures.
messages: Transcription factor that modulates the white-opaque switch.

237561:CAALFM CR05080WA
gene id: 237561:CAALFM_CR05080WA
uniprot id: A0A1D8PSX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

237561:CAALFM C306940WA
gene id: 237561:CAALFM_C306940WA
uniprot id: Q5ADN4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C604580WA
gene id: 237561:CAALFM_C604580WA
uniprot id: Q59RW5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Component of the N-acetylglucosamine catabolic cascade that phosphorylates N-acetylglucosamine (GlcNAc), and allows the unique ability to utilise GlcNAc as carbon source. Converts GlcNAc to GlcNAc-6-P. Also able to phosphorylate glucose, glucosamine (GlcN), and mannose. Galactose, fructose, N-acetylmannosamine (ManNAc), mannosamine (ManN), galactosamine (GalN), and N-acetylgalactosamine (GalNAc) are not phosphorylated by HXK1. GlcNAc metabolism is closely associated with virulence and morphogenesis, and is involved in the cell wall synthesis. Acts both as a repressor and an activator of genes involved in maintaining cellular homeostasis. Contributes to white-opaque morphological transition and plays a role as a filamentation repressor.
messages: Cytoplasm
messages: Expression is induced by N-acetylglucosamine (GlcNAc), by the alpha pheromone, and in filamentation-inducing media.
messages: Greatly retards the growth of cells using GlcNAc as the sole carbon source, increases resistance against farnesol, and attenuates the virulence in a mouse systemic infection model. Leads to derepression of opaque specific gene expression, as well as to constitutive filamentous growth and hyperfilamentation in filamentation-inducing conditions.
messages: Interacts with histone deacetylase SIR2 under filamentation-inducing conditions.
messages: Mitochondrion
messages: Nucleus

237561:CAALFM C108510WA
gene id: 237561:CAALFM_C108510WA
uniprot id: Q59QC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

237561:CAALFM C502920WA
gene id: 237561:CAALFM_C502920WA
uniprot id: A0A1D8PNJ2
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

237561:CAALFM C604620CA
gene id: 237561:CAALFM_C604620CA
uniprot id: Q59RG0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: Cell membrane
messages: Expression is induced in presence of cycloheximide and 4-nitroquinoline-N-oxide (PubMed:12589826). Expression is up-regulated during biofilm formation (PubMed:25784162).
messages: Leads to increased susceptibility to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, but not to actinomycin D, fluconazole, ketoconazole and colchicine (PubMed:12076781). Leads also to attenuated virulence in mice (PubMed:12076781).
messages: MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake (PubMed:19648376). Confers resistance to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence (PubMed:12076781, PubMed:12589826).

237561:CAALFM C106110CA
gene id: 237561:CAALFM_C106110CA
uniprot id: Q5AA50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
messages: Nucleus membrane
messages: perinuclear region

237561:CAALFM C303310CA
gene id: 237561:CAALFM_C303310CA
uniprot id: A0A1D8PJT1
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

237561:CAALFM CR08170CA
gene id: 237561:CAALFM_CR08170CA
uniprot id: Q5A387
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

237561:CAALFM C208120WA
gene id: 237561:CAALFM_C208120WA
uniprot id: A0A1D8PI21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

237561:CAALFM C407060WA
gene id: 237561:CAALFM_C407060WA
uniprot id: A0A1D8PMS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

237561:CAALFM CR02400WA
gene id: 237561:CAALFM_CR02400WA
uniprot id: A0A1D8PS71
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

237561:CAALFM C701640WA
gene id: 237561:CAALFM_C701640WA
uniprot id: Q5AGX8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

237561:CAALFM CR01970CA
gene id: 237561:CAALFM_CR01970CA
uniprot id: A0A1D8PS38
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

237561:CAALFM C101060WA
gene id: 237561:CAALFM_C101060WA
uniprot id: Q5A940
names: Function
names: Similarity
messages: Belongs to the MBF1 family.
messages: Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.

237561:CAALFM C209920WA
gene id: 237561:CAALFM_C209920WA
uniprot id: Q59YG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

237561:CAALFM CR04870CA
gene id: 237561:CAALFM_CR04870CA
uniprot id: A0A1D8PSW6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C501100CA
gene id: 237561:CAALFM_C501100CA
uniprot id: Q5A1N6
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cyclin family.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.
messages: Hyperphosphorylated. GRR1 preferentially mediates the degradation of hyperphosphorylated CLN3.
messages: Interacts with CDC28 and SLA1.
messages: Repressed by farnesol.

237561:CAALFM CR06530WA
gene id: 237561:CAALFM_CR06530WA
uniprot id: A0A1D8PT84
names: Similarity
messages: Belongs to the PDCD5 family.

237561:CAALFM C701300CA
gene id: 237561:CAALFM_C701300CA
uniprot id: Q59S42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

237561:CAALFM C206200CA
gene id: 237561:CAALFM_C206200CA
uniprot id: Q59P53
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

237561:CAALFM C202830CA
gene id: 237561:CAALFM_C202830CA
uniprot id: Q5A0I8
names: Similarity
messages: Belongs to the SGT family.

237561:CAALFM C204200WA
gene id: 237561:CAALFM_C204200WA
uniprot id: Q5AHJ5
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters.
messages: Expression is under the control of transcription factors SWI4 and SWI6.
messages: Nucleus
messages: telomere

237561:CAALFM C209160WA
gene id: 237561:CAALFM_C209160WA
uniprot id: Q59X53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

237561:CAALFM C400690CA
gene id: 237561:CAALFM_C400690CA
uniprot id: Q59SJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).

237561:CAALFM C111600WA
gene id: 237561:CAALFM_C111600WA
uniprot id: A0A1D8PF69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

237561:CAALFM CR09900CA
gene id: 237561:CAALFM_CR09900CA
uniprot id: A0A1D8PU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

237561:CAALFM C305560WA
gene id: 237561:CAALFM_C305560WA
uniprot id: A0A1D8PK85
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

237561:CAALFM C114410WA
gene id: 237561:CAALFM_C114410WA
uniprot id: A0A1D8PFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

237561:CAALFM C405050CA
gene id: 237561:CAALFM_C405050CA
uniprot id: Q5A6B6
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2A subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Inhibited by okadaic acid, a specific inhibitor of serine/threonine phosphatases of types 1, 2A and 2B.
messages: Leads to defect in morphogenesis and reduced virulence.
messages: Serine/threonine-protein phosphatase that plays an important role in controlling colony morphology, filament extension and agar invasion. Down-regulates expression of NRG1 and affects the expression of multiple filament-specific transcripts in response to serum and 37 degrees Celsius. Plays a crucial role in virulence in a mouse model of systemic candidiasis.

237561:CAALFM C500450CA
gene id: 237561:CAALFM_C500450CA
uniprot id: A0A1D8PMX7
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

237561:CAALFM C403940CA
gene id: 237561:CAALFM_C403940CA
uniprot id: A0A1D8PLY4
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

237561:CAALFM C113140CA
gene id: 237561:CAALFM_C113140CA
uniprot id: Q5AL36
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Expression is controlled by RTG1 and is down-regulated during mating process, yeast-to-hyphal transition, and in presence of benomyl, amphotericin B, and caspofungin.
messages: Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1.
messages: Nucleus

237561:CAALFM C604180WA
gene id: 237561:CAALFM_C604180WA
uniprot id: A0A1D8PQC4
names: Similarity
messages: Belongs to the peptidase M1 family.

237561:CAALFM C107890CA
gene id: 237561:CAALFM_C107890CA
uniprot id: A0A1D8PE67
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

237561:CAALFM C305720CA
gene id: 237561:CAALFM_C305720CA
uniprot id: A0A1D8PKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

237561:CAALFM C601780CA
gene id: 237561:CAALFM_C601780CA
uniprot id: Q5A4N6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201160WA
gene id: 237561:CAALFM_C201160WA
uniprot id: Q5AD59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C103920CA
gene id: 237561:CAALFM_C103920CA
uniprot id: Q59QL0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF4.
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.

237561:CAALFM C306720WA
gene id: 237561:CAALFM_C306720WA
uniprot id: Q5ADL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C701820CA
gene id: 237561:CAALFM_C701820CA
uniprot id: Q5AH00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

237561:CAALFM CR03830CA
gene id: 237561:CAALFM_CR03830CA
uniprot id: Q5A034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

237561:CAALFM CR10710CA
gene id: 237561:CAALFM_CR10710CA
uniprot id: A0A1D8PUA9
names: Similarity
messages: Belongs to the VPS52 family.

237561:CAALFM C603710WA
gene id: 237561:CAALFM_C603710WA
uniprot id: A0A1D8PQ86
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections (PubMed:17510860, PubMed:22321066, PubMed:22429754). Allele ALS9-2 contributes to endothelial cell adhesion, whereas ALS9-1 does not (PubMed:17600078).
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.
messages: N-glycosylated and O-glycosylated.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR07200WA
gene id: 237561:CAALFM_CR07200WA
uniprot id: A0A1D8PTF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

237561:CAALFM C112430WA
gene id: 237561:CAALFM_C112430WA
uniprot id: A0A1D8PFD7
names: Similarity
messages: Belongs to the SIN1 family.

237561:CAALFM C600910CA
gene id: 237561:CAALFM_C600910CA
uniprot id: A0A1D8PPH3
names: Similarity
messages: Belongs to the SH3BGR family.

237561:CAALFM C601050WA
gene id: 237561:CAALFM_C601050WA
uniprot id: Q59WU2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM CR09510CA
gene id: 237561:CAALFM_CR09510CA
uniprot id: A0A1D8PTZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

237561:CAALFM C602570CA
gene id: 237561:CAALFM_C602570CA
uniprot id: A0A1D8PPX8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C108740CA
gene id: 237561:CAALFM_C108740CA
uniprot id: Q5AQ76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

237561:CAALFM C501480WA
gene id: 237561:CAALFM_C501480WA
uniprot id: Q59NQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV7 family.
messages: Involved in the processing of the 20S pre-rRNA.
messages: nucleolus

237561:CAALFM C300750WA
gene id: 237561:CAALFM_C300750WA
uniprot id: A0A1D8PJ02
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C100970WA
gene id: 237561:CAALFM_C100970WA
uniprot id: A0A1D8PCD5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C105280WA
gene id: 237561:CAALFM_C105280WA
uniprot id: A0A1D8PDJ2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR07390CA
gene id: 237561:CAALFM_CR07390CA
uniprot id: Q59RQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

237561:CAALFM C102310CA
gene id: 237561:CAALFM_C102310CA
uniprot id: Q59W04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators (By similarity).
messages: Nucleus
messages: telomere

237561:CAALFM C307670WA
gene id: 237561:CAALFM_C307670WA
uniprot id: Q5ADX1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C107070CA
gene id: 237561:CAALFM_C107070CA
uniprot id: Q5AAW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: P-body
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C305740CA
gene id: 237561:CAALFM_C305740CA
uniprot id: Q5A4H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the SRB8-11 complex, a regulatory module of the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
messages: Nucleus

237561:CAALFM C304930CA
gene id: 237561:CAALFM_C304930CA
uniprot id: Q5ANE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C407140WA
gene id: 237561:CAALFM_C407140WA
uniprot id: Q5A107
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

237561:CAALFM C202610CA
gene id: 237561:CAALFM_C202610CA
uniprot id: Q5ALJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C100960CA
gene id: 237561:CAALFM_C100960CA
uniprot id: Q5ABG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

237561:CAALFM C302560WA
gene id: 237561:CAALFM_C302560WA
uniprot id: A0A1D8PJM0
names: Function
names: Similarity
messages: Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
messages: Belongs to the rad9 family.

237561:CAALFM C114150CA
gene id: 237561:CAALFM_C114150CA
uniprot id: Q59ZW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
messages: Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity).

237561:CAALFM C208560WA
gene id: 237561:CAALFM_C208560WA
uniprot id: A0A1D8PI59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

237561:CAALFM C205000CA
gene id: 237561:CAALFM_C205000CA
uniprot id: Q59ZI7
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

237561:CAALFM C601990WA
gene id: 237561:CAALFM_C601990WA
uniprot id: Q9UWF6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysophospholipase family.
messages: Catalyzes the release of fatty acids from lysophospholipids (By similarity). Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (PubMed:9748287).
messages: Expressed during candidal infection of mice.
messages: Reduces dramatically the ability to penetrate host cells.
messages: Secreted

237561:CAALFM C702130WA
gene id: 237561:CAALFM_C702130WA
uniprot id: A0A1D8PR28
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C204540CA
gene id: 237561:CAALFM_C204540CA
uniprot id: A0A1D8PH63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

237561:CAALFM C111650WA
gene id: 237561:CAALFM_C111650WA
uniprot id: Q59TU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

237561:CAALFM C701610WA
gene id: 237561:CAALFM_C701610WA
uniprot id: A0A1D8PQV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

237561:CAALFM C700590WA
gene id: 237561:CAALFM_C700590WA
uniprot id: A0A1D8PQM0
names: Similarity
messages: Belongs to the XRCC4-XLF family. XLF subfamily.

237561:CAALFM C112280CA
gene id: 237561:CAALFM_C112280CA
uniprot id: Q5A3N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

237561:CAALFM C201390WA
gene id: 237561:CAALFM_C201390WA
uniprot id: A0A1D8PGB7
names: Similarity
messages: Belongs to the epsin family.

237561:CAALFM C202200WA
gene id: 237561:CAALFM_C202200WA
uniprot id: A0A1D8PGL8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C305240CA
gene id: 237561:CAALFM_C305240CA
uniprot id: Q5ANA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C303590WA
gene id: 237561:CAALFM_C303590WA
uniprot id: A0A1D8PJT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

237561:CAALFM CR07860CA
gene id: 237561:CAALFM_CR07860CA
uniprot id: Q59MV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

237561:CAALFM C105180CA
gene id: 237561:CAALFM_C105180CA
uniprot id: A0A1D8PDI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

237561:CAALFM C109380WA
gene id: 237561:CAALFM_C109380WA
uniprot id: Q9UW12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the palA/RIM20 family.
messages: Interacts with RIM101 by binding to its two YPX[LI] motifs.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via SNF7 to its substrate RIM101 (By similarity). Required for filamentation.

237561:CAALFM C305160CA
gene id: 237561:CAALFM_C305160CA
uniprot id: Q5ANB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C406440CA
gene id: 237561:CAALFM_C406440CA
uniprot id: A0A1D8PML3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404230WA
gene id: 237561:CAALFM_C404230WA
uniprot id: Q59P89
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C601350WA
gene id: 237561:CAALFM_C601350WA
uniprot id: A0A1D8PPK7
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

237561:CAALFM C500210CA
gene id: 237561:CAALFM_C500210CA
uniprot id: Q5A4X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
messages: Nucleus

237561:CAALFM C200030WA
gene id: 237561:CAALFM_C200030WA
uniprot id: Q59L42
names: Similarity
messages: Belongs to the RRN3 family.

237561:CAALFM C109070WA
gene id: 237561:CAALFM_C109070WA
uniprot id: Q5APK0
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

237561:CAALFM CR09970WA
gene id: 237561:CAALFM_CR09970WA
uniprot id: A0A1D8PU40
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C109080CA
gene id: 237561:CAALFM_C109080CA
uniprot id: Q5APJ9
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Membrane
messages: Probable cell wall protein that participates directly in adhesive cell-cell interactions.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: The PGA6 mRNA is transported by SHE3 to the hyphal tips during filamentous growth.
messages: Up-regulated by high iron, during biofilm development, and upon ALS2 depletion.
messages: cell wall

237561:CAALFM C300270CA
gene id: 237561:CAALFM_C300270CA
uniprot id: Q5A7M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM CR07320CA
gene id: 237561:CAALFM_CR07320CA
uniprot id: Q59RP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU).
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

237561:CAALFM C210340WA
gene id: 237561:CAALFM_C210340WA
uniprot id: A0A1D8PIS5
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

237561:CAALFM C200480CA
gene id: 237561:CAALFM_C200480CA
uniprot id: Q5ACY8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

237561:CAALFM C601480WA
gene id: 237561:CAALFM_C601480WA
uniprot id: Q5A4K5
names: Similarity
messages: Belongs to the Rho GDI family.

237561:CAALFM C110400CA
gene id: 237561:CAALFM_C110400CA
uniprot id: Q5AP52
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Affects yeast-to hyphal transition.
messages: Cell membrane
messages: Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth.
messages: Secreted

237561:CAALFM CR02530WA
gene id: 237561:CAALFM_CR02530WA
uniprot id: Q59LU0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
messages: Associates with polysomes.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C105260CA
gene id: 237561:CAALFM_C105260CA
uniprot id: Q5A2A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

237561:CAALFM C305230WA
gene id: 237561:CAALFM_C305230WA
uniprot id: P0CY29
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae and true hyphae.
messages: Inhibited by pepstatin A analogs.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C304830CA
gene id: 237561:CAALFM_C304830CA
uniprot id: A0A1D8PK65
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

237561:CAALFM C304710WA
gene id: 237561:CAALFM_C304710WA
uniprot id: Q5ANH2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Leads to avirulence using a BALB/c disseminated mouse model.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake. Plays a role in pathogenesis.

237561:CAALFM C203430WA
gene id: 237561:CAALFM_C203430WA
uniprot id: Q5AHB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

237561:CAALFM C300640WA
gene id: 237561:CAALFM_C300640WA
uniprot id: Q5A7S3
names: Similarity
messages: Belongs to the group II decarboxylase family.

237561:CAALFM C112600CA
gene id: 237561:CAALFM_C112600CA
uniprot id: Q9Y7C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM CR00150CA
gene id: 237561:CAALFM_CR00150CA
uniprot id: A0A1D8PRL6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

237561:CAALFM C208140CA
gene id: 237561:CAALFM_C208140CA
uniprot id: A0A1D8PI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

237561:CAALFM C306990WA
gene id: 237561:CAALFM_C306990WA
uniprot id: Q5ADN9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
messages: Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: Vacuole membrane

237561:CAALFM C108810CA
gene id: 237561:CAALFM_C108810CA
uniprot id: Q5APM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity).
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: Mitochondrion matrix
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C106210WA
gene id: 237561:CAALFM_C106210WA
uniprot id: Q59MC6
names: Similarity
messages: Belongs to the pyridoxine kinase family.

237561:CAALFM C405350WA
gene id: 237561:CAALFM_C405350WA
uniprot id: Q59P11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Cytoplasmic vesicle membrane
messages: Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
messages: May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: Vacuole membrane

237561:CAALFM C302820CA
gene id: 237561:CAALFM_C302820CA
uniprot id: A0A1D8PJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C601680CA
gene id: 237561:CAALFM_C601680CA
uniprot id: A0A1D8PPP3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

237561:CAALFM C301810CA
gene id: 237561:CAALFM_C301810CA
uniprot id: Q00310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Golgi apparatus membrane
messages: Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Mainly responsible for the addition of the second mannose residue in an O-linked mannose pentamer. Can also substitute for MNT2 by adding the third mannose residue. Important for adherence to host surfaces and for virulence.

237561:CAALFM C304070CA
gene id: 237561:CAALFM_C304070CA
uniprot id: A0A1D8PK15
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C600070CA
gene id: 237561:CAALFM_C600070CA
uniprot id: Q59L86
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: Up-regulated in biofilm, in oralpharyngeal candidasis, and upon milbemycins A3 oxim derivative (A3Ox). Down-regulated by fluconazole.
messages: cell wall

237561:CAALFM CR05260CA
gene id: 237561:CAALFM_CR05260CA
uniprot id: Q59KK0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

237561:CAALFM C301790CA
gene id: 237561:CAALFM_C301790CA
uniprot id: Q5AJC4
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C206130WA
gene id: 237561:CAALFM_C206130WA
uniprot id: Q59X26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

237561:CAALFM C201580WA
gene id: 237561:CAALFM_C201580WA
uniprot id: A0A1D8PGG3
names: Similarity
messages: Belongs to the oligoribonuclease family.

237561:CAALFM C204160WA
gene id: 237561:CAALFM_C204160WA
uniprot id: Q5AHJ1
names: Similarity
messages: Belongs to the TACO1 family.

237561:CAALFM C502150CA
gene id: 237561:CAALFM_C502150CA
uniprot id: A0A1D8PNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Nucleus

237561:CAALFM C304800CA
gene id: 237561:CAALFM_C304800CA
uniprot id: Q5ANG0
names: Subcellular Location Annotation
messages: Peroxisome membrane

237561:CAALFM CR09190CA
gene id: 237561:CAALFM_CR09190CA
uniprot id: A0A1D8PTW1
names: Similarity
messages: Belongs to the PhyH family.

237561:CAALFM C202670CA
gene id: 237561:CAALFM_C202670CA
uniprot id: A0A1D8PGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA2 family.
messages: Cell projection
messages: Cytoplasm

237561:CAALFM CR02350CA
gene id: 237561:CAALFM_CR02350CA
uniprot id: A0A1D8PS75
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C112850WA
gene id: 237561:CAALFM_C112850WA
uniprot id: P0CT51
names: Function
names: Induction
messages: Highly up-regulated by fetal bovine serum.
messages: Plays an important role in survival in host blood through increasing tolerance to stresses such as heat, salt, or cycloheximide, which is essential for virulence.

237561:CAALFM C302030WA
gene id: 237561:CAALFM_C302030WA
uniprot id: A0A1D8PJD6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR01210CA
gene id: 237561:CAALFM_CR01210CA
uniprot id: Q5A895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Endosome membrane

237561:CAALFM C113060CA
gene id: 237561:CAALFM_C113060CA
uniprot id: Q5AL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

237561:CAALFM C307420WA
gene id: 237561:CAALFM_C307420WA
uniprot id: Q5ADU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

237561:CAALFM CR00360CA
gene id: 237561:CAALFM_CR00360CA
uniprot id: A0A1D8PRP8
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

237561:CAALFM C105640CA
gene id: 237561:CAALFM_C105640CA
uniprot id: Q5A9Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C108200WA
gene id: 237561:CAALFM_C108200WA
uniprot id: A0A1D8PE92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Nucleus

237561:CAALFM C603600CA
gene id: 237561:CAALFM_C603600CA
uniprot id: A0A1D8PQ77
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM C403550WA
gene id: 237561:CAALFM_C403550WA
uniprot id: A0A1D8PLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

237561:CAALFM C305960WA
gene id: 237561:CAALFM_C305960WA
uniprot id: A0A1D8PKC6
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

237561:CAALFM C101830CA
gene id: 237561:CAALFM_C101830CA
uniprot id: Q59T91
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C502770WA
gene id: 237561:CAALFM_C502770WA
uniprot id: Q5AG80
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C106590CA
gene id: 237561:CAALFM_C106590CA
uniprot id: Q5AAR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).

237561:CAALFM CR02180WA
gene id: 237561:CAALFM_CR02180WA
uniprot id: Q59UY6
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

237561:CAALFM CR01400WA
gene id: 237561:CAALFM_CR01400WA
uniprot id: Q5A9D9
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

237561:CAALFM C106480CA
gene id: 237561:CAALFM_C106480CA
uniprot id: A0A1D8PDT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

237561:CAALFM C209870WA
gene id: 237561:CAALFM_C209870WA
uniprot id: Q59YG2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C103480CA
gene id: 237561:CAALFM_C103480CA
uniprot id: A0A1D8PD25
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

237561:CAALFM C300390WA
gene id: 237561:CAALFM_C300390WA
uniprot id: Q5A7N9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C700430WA
gene id: 237561:CAALFM_C700430WA
uniprot id: A0A1D8PQM2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C604340WA
gene id: 237561:CAALFM_C604340WA
uniprot id: A0A1D8PQE0
names: Function
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR04050CA
gene id: 237561:CAALFM_CR04050CA
uniprot id: P84149
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: Interacts with nucleoporin complex protein MTR2.
messages: Involved in the export of mRNA from the nucleus to the cytoplasm.
messages: Nucleus
messages: The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.
messages: The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

237561:CAALFM C601840CA
gene id: 237561:CAALFM_C601840CA
uniprot id: Q5A4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

237561:CAALFM C702880CA
gene id: 237561:CAALFM_C702880CA
uniprot id: Q9P4E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C406850CA
gene id: 237561:CAALFM_C406850CA
uniprot id: A0A1D8PMP9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

237561:CAALFM C306440WA
gene id: 237561:CAALFM_C306440WA
uniprot id: A0A1D8PKH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

237561:CAALFM C500810CA
gene id: 237561:CAALFM_C500810CA
uniprot id: Q59X94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

237561:CAALFM C109920WA
gene id: 237561:CAALFM_C109920WA
uniprot id: A0A1D8PEQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Required for vacuolar assembly and vacuolar traffic.
messages: Vacuole

237561:CAALFM CR07160CA
gene id: 237561:CAALFM_CR07160CA
uniprot id: Q59TZ9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C107430WA
gene id: 237561:CAALFM_C107430WA
uniprot id: Q59WE5
names: Similarity
messages: Belongs to the SurE nucleotidase family.

237561:CAALFM C604100WA
gene id: 237561:CAALFM_C604100WA
uniprot id: A0A1D8PQC2
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

237561:CAALFM C203990WA
gene id: 237561:CAALFM_C203990WA
uniprot id: A0A1D8PH13
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

237561:CAALFM C307290WA
gene id: 237561:CAALFM_C307290WA
uniprot id: Q5ADS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C301720CA
gene id: 237561:CAALFM_C301720CA
uniprot id: A0A1D8PJB0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

237561:CAALFM CR02890CA
gene id: 237561:CAALFM_CR02890CA
uniprot id: Q5A246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
messages: Nucleus

237561:CAALFM C702380CA
gene id: 237561:CAALFM_C702380CA
uniprot id: P22011
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM CR09310WA
gene id: 237561:CAALFM_CR09310WA
uniprot id: A0A1D8PTX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.

237561:CAALFM C100130CA
gene id: 237561:CAALFM_C100130CA
uniprot id: Q5AB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

237561:CAALFM C111920WA
gene id: 237561:CAALFM_C111920WA
uniprot id: Q5A3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

237561:CAALFM C301370CA
gene id: 237561:CAALFM_C301370CA
uniprot id: Q5AJK6
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C700390WA
gene id: 237561:CAALFM_C700390WA
uniprot id: P87185
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.
messages: Expression is up-regulated at high-iron conditions.
messages: Mitochondrion

237561:CAALFM C102440CA
gene id: 237561:CAALFM_C102440CA
uniprot id: A0A1D8PCR2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

237561:CAALFM C108780WA
gene id: 237561:CAALFM_C108780WA
uniprot id: Q5APN0
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

237561:CAALFM C109870WA
gene id: 237561:CAALFM_C109870WA
uniprot id: Q5APB2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C201210CA
gene id: 237561:CAALFM_C201210CA
uniprot id: A0A1D8PGA9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109370WA
gene id: 237561:CAALFM_C109370WA
uniprot id: Q5APG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CEF1 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and cell cycle control.
messages: Nucleus

237561:CAALFM C405010WA
gene id: 237561:CAALFM_C405010WA
uniprot id: A0A1D8PM77
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM CR10140WA
gene id: 237561:CAALFM_CR10140WA
uniprot id: A0A1D8PU51
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.

237561:CAALFM C406930CA
gene id: 237561:CAALFM_C406930CA
uniprot id: Q5A0Y0
names: Similarity
messages: Belongs to the Luc7 family.

237561:CAALFM CR10570CA
gene id: 237561:CAALFM_CR10570CA
uniprot id: A0A1D8PU81
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

237561:CAALFM C505210WA
gene id: 237561:CAALFM_C505210WA
uniprot id: A0A1D8PP72
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404220WA
gene id: 237561:CAALFM_C404220WA
uniprot id: Q59P88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DUO1 family.
messages: Nucleus
messages: kinetochore

237561:CAALFM CR01520WA
gene id: 237561:CAALFM_CR01520WA
uniprot id: A0A1D8PRZ8
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM CR01110WA
gene id: 237561:CAALFM_CR01110WA
uniprot id: Q5A885
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
messages: The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

237561:CAALFM C114270WA
gene id: 237561:CAALFM_C114270WA
uniprot id: Q59ZV4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

237561:CAALFM C600510CA
gene id: 237561:CAALFM_C600510CA
uniprot id: Q59NG2
names: Similarity
messages: Belongs to the RAD52 family.

237561:CAALFM C110030WA
gene id: 237561:CAALFM_C110030WA
uniprot id: Q5APT8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C100860WA
gene id: 237561:CAALFM_C100860WA
uniprot id: Q5ABQ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
messages: Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Interacts also with the ATG12-ATG5 conjugate.
messages: The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.
messages: The flexible region (FR) is required for ATG7-binding.
messages: The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).

237561:CAALFM C303330CA
gene id: 237561:CAALFM_C303330CA
uniprot id: Q5AED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
messages: Nucleus

237561:CAALFM C209020WA
gene id: 237561:CAALFM_C209020WA
uniprot id: A0A1D8PIE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

237561:CAALFM C504210CA
gene id: 237561:CAALFM_C504210CA
uniprot id: Q5AKB6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C703770CA
gene id: 237561:CAALFM_C703770CA
uniprot id: Q59LC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAF9 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The coiled-coil domain is required for assembly into the NuA4 complex.

237561:CAALFM C501780WA
gene id: 237561:CAALFM_C501780WA
uniprot id: Q9UW26
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (By similarity).
messages: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

237561:CAALFM C500860WA
gene id: 237561:CAALFM_C500860WA
uniprot id: A0A1D8PN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C202590WA
gene id: 237561:CAALFM_C202590WA
uniprot id: A0A1D8PGN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C303560WA
gene id: 237561:CAALFM_C303560WA
uniprot id: Q5AEB4
names: Similarity
messages: Belongs to the peptidase M24B family.

237561:CAALFM C103000WA
gene id: 237561:CAALFM_C103000WA
uniprot id: A0A1D8PCW2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C303930WA
gene id: 237561:CAALFM_C303930WA
uniprot id: Q59SU6
names: Similarity
messages: Belongs to the TAF11 family.

237561:CAALFM CR00410WA
gene id: 237561:CAALFM_CR00410WA
uniprot id: Q5AAJ8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTT109 family.
messages: Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:20601951, PubMed:20080646). Plays an important role in the regulation of white-opaque genotoxin induced-switching (PubMed:21749487).
messages: Leads to a decreased pathogenicity in mice and increased susceptibility to killing by macrophages in vitro.
messages: Nucleus

237561:CAALFM C102740CA
gene id: 237561:CAALFM_C102740CA
uniprot id: Q5AI90
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-67 and Arg-70) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

237561:CAALFM C113680CA
gene id: 237561:CAALFM_C113680CA
uniprot id: Q5AKX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

237561:CAALFM C106900CA
gene id: 237561:CAALFM_C106900CA
uniprot id: A0A1D8PDX5
names: Similarity
messages: Belongs to the RutC family.

237561:CAALFM CR02850CA
gene id: 237561:CAALFM_CR02850CA
uniprot id: Q5A201
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Induced via CAP1 during oxitive stress, as well as during biofilm formation.
messages: Leads to altered sensitivity to fluconazole, LiCl, and copper.
messages: Nucleus
messages: Probable transcription factor involved in response to fluconazole, LiCl, and copper.

237561:CAALFM CR03920CA
gene id: 237561:CAALFM_CR03920CA
uniprot id: A0A1D8PSL9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C501130WA
gene id: 237561:CAALFM_C501130WA
uniprot id: A0A1D8PN32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C210090CA
gene id: 237561:CAALFM_C210090CA
uniprot id: A0A1D8PIL7
names: Function
names: Similarity
messages: Belongs to the CCM1 family.
messages: RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.

237561:CAALFM C406720WA
gene id: 237561:CAALFM_C406720WA
uniprot id: Q5A0V9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

237561:CAALFM C303750CA
gene id: 237561:CAALFM_C303750CA
uniprot id: Q59SS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

237561:CAALFM C103600WA
gene id: 237561:CAALFM_C103600WA
uniprot id: Q5AHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

237561:CAALFM C200970CA
gene id: 237561:CAALFM_C200970CA
uniprot id: A0A1D8PG89
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C701540WA
gene id: 237561:CAALFM_C701540WA
uniprot id: Q5AGW4
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM C105670WA
gene id: 237561:CAALFM_C105670WA
uniprot id: Q5AA00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Vacuole membrane

237561:CAALFM CR02170WA
gene id: 237561:CAALFM_CR02170WA
uniprot id: Q5A948
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

237561:CAALFM C402840CA
gene id: 237561:CAALFM_C402840CA
uniprot id: A0A1D8PLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C209610WA
gene id: 237561:CAALFM_C209610WA
uniprot id: A0A1D8PIH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C205690CA
gene id: 237561:CAALFM_C205690CA
uniprot id: Q59T36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

237561:CAALFM C703980WA
gene id: 237561:CAALFM_C703980WA
uniprot id: A0A1D8PRI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR07380CA
gene id: 237561:CAALFM_CR07380CA
uniprot id: Q59RQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane

237561:CAALFM C103270WA
gene id: 237561:CAALFM_C103270WA
uniprot id: A0A1D8PD03
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

237561:CAALFM C100590WA
gene id: 237561:CAALFM_C100590WA
uniprot id: Q5ABC3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

237561:CAALFM C204290WA
gene id: 237561:CAALFM_C204290WA
uniprot id: A0A1D8PH74
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

237561:CAALFM C306220CA
gene id: 237561:CAALFM_C306220CA
uniprot id: A0A1D8PKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C200190CA
gene id: 237561:CAALFM_C200190CA
uniprot id: Q5ACV4
names: Subcellular Location Annotation
messages: Peroxisome membrane

237561:CAALFM C504810WA
gene id: 237561:CAALFM_C504810WA
uniprot id: Q5AK53
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.

237561:CAALFM CR01760CA
gene id: 237561:CAALFM_CR01760CA
uniprot id: A0A1D8PS16
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

237561:CAALFM C702170CA
gene id: 237561:CAALFM_C702170CA
uniprot id: Q5AH41
names: Similarity
messages: Belongs to the IWR1/SLC7A6OS family.

237561:CAALFM C114310WA
gene id: 237561:CAALFM_C114310WA
uniprot id: A0A1D8PFW6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

237561:CAALFM C403450CA
gene id: 237561:CAALFM_C403450CA
uniprot id: Q59PG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

237561:CAALFM C200400CA
gene id: 237561:CAALFM_C200400CA
uniprot id: A0A1D8PG37
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

237561:CAALFM C100610WA
gene id: 237561:CAALFM_C100610WA
uniprot id: Q5ABC5
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A psd1 psd2 double mutant displays diminished phosphatidylethanolamine levels. It exhibits defects in cell wall integrity, mitochondrial function, filamentous growth and is less virulent than the wild-type.
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Important for virulence (PubMed:20132453).
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

237561:CAALFM C402320CA
gene id: 237561:CAALFM_C402320CA
uniprot id: A0A1D8PLJ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

237561:CAALFM C703540CA
gene id: 237561:CAALFM_C703540CA
uniprot id: A0A1D8PRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

237561:CAALFM CR10840CA
gene id: 237561:CAALFM_CR10840CA
uniprot id: A0A1D8PUB4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C306740WA
gene id: 237561:CAALFM_C306740WA
uniprot id: Q5ADL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AEP2 family.
messages: Binds to the 5'UTR of the OLI1 mRNA.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.

237561:CAALFM C302480CA
gene id: 237561:CAALFM_C302480CA
uniprot id: Q5AEN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Forms a one-to-one complex with cytochrome c.
messages: Mitochondrion matrix

237561:CAALFM C302220WA
gene id: 237561:CAALFM_C302220WA
uniprot id: Q5AJU7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. YAP subfamily.
messages: Causes hypersensitivity to cadmium, 4-nitroquinoline N-oxide, 1,10-phenanthroline, and hydrogen peroxide. Abolishes the peroxide-mediated induction of COR33, TSA1, and many other genes involved in oxidative stress response. Inhibits trehalose accumulation upon exposure to oxidative stress. Shows significantly reduced viability when exposed to whole blood or polymorphonuclear cells, as well as to the Chinese herbal medicine baicalein. Leads also to decreased virulence in a Caenorhabditis elegans model. Increases apoptosis upon apoptotic stimulation.
messages: Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD (Cys-254 and Cys-261) and c-CRD (Cys-446, Cys-468 and Cys-477), respectively. A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein CRM1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD.
messages: Cytoplasm
messages: Induced by oxidative stress and during contact with neutrophils. Expression is also up-regulated by the thioredoxin TRX1 and by treatment with Chinese herbal medicine baicalein.
messages: Interacts with YBP1.
messages: Nucleus
messages: Phosphorylated in response to H(2)O(2).
messages: Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) generated by the host immune system, is required for survival in the host and therefore virulence. Regulates the transcription of COR33, GLR1, GTO1, GTT1, GTT1, TRR1, TRX1, SOD1, CAT1, and the transcription regulator TSA1. Participates in the apoptosis by regulating the expression of the glutathione reductase gene and glutathione content. Also plays a role in the peroxide-mediated induction of MDR1 and other drug response genes such as PDR16, MDR1, FLU1, YCF1, and FCR1. Regulates trehalose accumulation which is important for the oxidative stress tolerance. Recruits ADA2 to its target promoters. Activity of CAP1 is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress induces nuclear accumulation and as a result CAP1 transcriptional activity. Nuclear export is restored when disulfide bonds are reduced by thioredoxin, whose expression is controlled by CAP1, providing a mechanism for negative autoregulation.
messages: Upon oxidative stress, is oxidated by the peroxidase GPX3 and stabilized by YBP1 (PubMed:20679492, PubMed:23706023). Oxidative stress induces conformational changes through oxidation of cysteine residues, masking the nuclear export signal, thus abolishing nuclear export by CRM1/exportin 1 (By similarity).

237561:CAALFM C304670CA
gene id: 237561:CAALFM_C304670CA
uniprot id: A0A1D8PK22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS15 has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C504180WA
gene id: 237561:CAALFM_C504180WA
uniprot id: A0A1D8PNW3
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

237561:CAALFM C209950WA
gene id: 237561:CAALFM_C209950WA
uniprot id: A0A1D8PIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM CR05310WA
gene id: 237561:CAALFM_CR05310WA
uniprot id: Q59KJ6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

237561:CAALFM C702830CA
gene id: 237561:CAALFM_C702830CA
uniprot id: Q9P8W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C102620CA
gene id: 237561:CAALFM_C102620CA
uniprot id: Q5AIA2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

237561:CAALFM CR01280CA
gene id: 237561:CAALFM_CR01280CA
uniprot id: Q5A8A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPC2 family.
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

237561:CAALFM C700210CA
gene id: 237561:CAALFM_C700210CA
uniprot id: A0A1D8PQI3
names: Similarity
messages: Belongs to the TEL2 family.

237561:CAALFM C504790CA
gene id: 237561:CAALFM_C504790CA
uniprot id: A0A1D8PP17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

237561:CAALFM C303640WA
gene id: 237561:CAALFM_C303640WA
uniprot id: Q59SR3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C600770CA
gene id: 237561:CAALFM_C600770CA
uniprot id: A0A1D8PPF7
names: Similarity
messages: Belongs to the EME1/MMS4 family.

237561:CAALFM CR09980WA
gene id: 237561:CAALFM_CR09980WA
uniprot id: A0A1D8PU33
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C307120WA
gene id: 237561:CAALFM_C307120WA
uniprot id: Q5ADQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRI1 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM CR10100CA
gene id: 237561:CAALFM_CR10100CA
uniprot id: P42800
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myo-inositol 1-phosphate synthase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Inositol auxotrophy (PubMed:18268031). Virulence is not affected in a mouse model of disseminated infection (PubMed:18268031). Simultaneous disruption of ITR1 results in lethality (PubMed:18268031).
messages: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:18268031). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).

237561:CAALFM C208310WA
gene id: 237561:CAALFM_C208310WA
uniprot id: A0A1D8PI78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C105770CA
gene id: 237561:CAALFM_C105770CA
uniprot id: A0A1D8PDM9
names: Similarity
messages: Belongs to the peptidase S10 family.

237561:CAALFM C306100CA
gene id: 237561:CAALFM_C306100CA
uniprot id: Q5A4E2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM CR01960CA
gene id: 237561:CAALFM_CR01960CA
uniprot id: Q5A970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
messages: Homopentamer. Forms homooligomers. Interacts with MFM1.
messages: Mitochondrion inner membrane

237561:CAALFM C113450WA
gene id: 237561:CAALFM_C113450WA
uniprot id: Q5AL03
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HYR1/IFF family.
messages: Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1.
messages: GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin-forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections.
messages: Induced specifically in response to hyphal growth. Expression is repressed by neutrophils and purpurin. Regulated by RFG1, EFG1, NRG1, TUP1, CYR1, BCR1, and HAP43.
messages: Leads to attenuated virulence in a mouse oral biofilm model of infection.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C106710WA
gene id: 237561:CAALFM_C106710WA
uniprot id: Q5AAS1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

237561:CAALFM C702500CA
gene id: 237561:CAALFM_C702500CA
uniprot id: Q5AH74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

237561:CAALFM C603620CA
gene id: 237561:CAALFM_C603620CA
uniprot id: A0A1D8PQ75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family. UbiD-like/FDC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
messages: Cytoplasm
messages: Homodimer. May form higher order oligomers.

237561:CAALFM C300650WA
gene id: 237561:CAALFM_C300650WA
uniprot id: Q5A7S4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C403620CA
gene id: 237561:CAALFM_C403620CA
uniprot id: A0A1D8PLV0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00970WA
gene id: 237561:CAALFM_CR00970WA
uniprot id: Q5A867
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C104230WA
gene id: 237561:CAALFM_C104230WA
uniprot id: A0A1D8PDB0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C109430WA
gene id: 237561:CAALFM_C109430WA
uniprot id: A0A1D8PEK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

237561:CAALFM C109090CA
gene id: 237561:CAALFM_C109090CA
uniprot id: A0A1D8PEG7
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C505280CA
gene id: 237561:CAALFM_C505280CA
uniprot id: Q5AJZ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C703920CA
gene id: 237561:CAALFM_C703920CA
uniprot id: A0A1D8PRG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

237561:CAALFM C405880WA
gene id: 237561:CAALFM_C405880WA
uniprot id: Q5A432
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced by rapamycine.
messages: Nucleus
messages: Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model.

237561:CAALFM C304810CA
gene id: 237561:CAALFM_C304810CA
uniprot id: A0A1D8PK71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with mature 80S ribosomes. Binds to the head domain of the 40S ribosomal subunit and prevents mRNA binding by inserting its alpha-helix domain towards the mRNA entry tunnel at the decoding site, where it blocks the binding of tRNA and mRNA at the A- and P-sites (Probable). Interacts with eEF2; interaction sequesters eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity).
messages: Belongs to the STM1 family.
messages: Cytoplasm
messages: Phosphorylation by TORC1 upon nutrient replenishment inhibits STM1 and causes its release from dormant ribosomes.
messages: Ribosome preservation factor that protect a small pool of nontranslating, vacant ribosomes in cells under nutrient starvation conditions. Under nutrient-limiting conditions, cells reduce ribosome biogenesis and degrade ribosomes via autophagy (ribophagy) or proteasomal degradation. To avoid excessive degradation during starvation, STM1 binds to and protects 80S ribosomes from proteasomal degradation. Under nutrient-sufficient conditions, TORC1 phosphorylates and inhibits STM1 to prevent formation of dormant 80S ribosomes. Acts as an inhibitor of mRNA translation by promoting ribosome hibernation: clamps the two ribosomal subunits, thereby preventing their dissociation, and inhibits translation by excluding mRNA-binding. Acts via its association with eEF2, promoting ribosome stabilization and storage in an inactive state. May also repress translation by preventing association of eEF3 with ribosomes. Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs.

237561:CAALFM C112570CA
gene id: 237561:CAALFM_C112570CA
uniprot id: Q59M28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C305600WA
gene id: 237561:CAALFM_C305600WA
uniprot id: A0A1D8PKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C405220CA
gene id: 237561:CAALFM_C405220CA
uniprot id: A0A1D8PM98
names: Similarity
messages: Belongs to the APC5 family.

237561:CAALFM C102630CA
gene id: 237561:CAALFM_C102630CA
uniprot id: Q5AIA1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. EXG2 is not heavily involved in the exoglucanase function of the adhesion process.
messages: Cell membrane
messages: Induced during cell wall regeneration and repressed by HAP43.
messages: Predicted to be a substrate for cleavage by KEX2.
messages: Secreted

237561:CAALFM C601750CA
gene id: 237561:CAALFM_C601750CA
uniprot id: A0A1D8PPQ5
names: Similarity
messages: Belongs to the pyridoxine kinase family.

237561:CAALFM C109690WA
gene id: 237561:CAALFM_C109690WA
uniprot id: Q5APD2
names: Similarity
messages: Belongs to the malate synthase family.

237561:CAALFM C603300CA
gene id: 237561:CAALFM_C603300CA
uniprot id: A0A1D8PQ45
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

237561:CAALFM C704300WA
gene id: 237561:CAALFM_C704300WA
uniprot id: Q3MNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

237561:CAALFM C206330CA
gene id: 237561:CAALFM_C206330CA
uniprot id: Q59P40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C103060CA
gene id: 237561:CAALFM_C103060CA
uniprot id: Q5AI56
names: Similarity
messages: Belongs to the TSR2 family.

237561:CAALFM C402460WA
gene id: 237561:CAALFM_C402460WA
uniprot id: Q5AF52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR02860WA
gene id: 237561:CAALFM_CR02860WA
uniprot id: O42825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane

237561:CAALFM C205840WA
gene id: 237561:CAALFM_C205840WA
uniprot id: Q59MG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm

237561:CAALFM C401220CA
gene id: 237561:CAALFM_C401220CA
uniprot id: A0A1D8PL94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

237561:CAALFM C102330CA
gene id: 237561:CAALFM_C102330CA
uniprot id: A0A1D8PCQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR00800CA
gene id: 237561:CAALFM_CR00800CA
uniprot id: Q5A852
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

237561:CAALFM C504190WA
gene id: 237561:CAALFM_C504190WA
uniprot id: A0A1D8PNW4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR10700WA
gene id: 237561:CAALFM_CR10700WA
uniprot id: A0A1D8PU93
names: Similarity
messages: Belongs to the activator 1 small subunits family.

237561:CAALFM C102510WA
gene id: 237561:CAALFM_C102510WA
uniprot id: Q5AIB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOS1 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: SNARE required for protein transport between the ER and the Golgi complex.

237561:CAALFM C404470WA
gene id: 237561:CAALFM_C404470WA
uniprot id: Q5A651
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Cell membrane
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Required for cell surface integrity and cell separation during budding.

237561:CAALFM C400950CA
gene id: 237561:CAALFM_C400950CA
uniprot id: A0A1D8PL60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C112380CA
gene id: 237561:CAALFM_C112380CA
uniprot id: Q5A3P4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C206590CA
gene id: 237561:CAALFM_C206590CA
uniprot id: Q59Q30
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Abolished the utilization of glycerophosphoinositol(GroPIns) as a phosphate source (PubMed:21984707).
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Glycerophosphodiester transporter that mediates uptake of glycerophosphoinositol (GroPIns) as a source of inositol and phosphate (PubMed:21984707, PubMed:24114876). Does not possess detectable glycerophosphocholine (GroPCho) transport activity (PubMed:21984707). Although no glycerophosphoinositol transport activity occurs in the absence of GIT1, C.albicans is still able to use glycerophosphoinositol as a phosphate source at pH 7.5, albeit slowly (PubMed:21984707). Thus, a second, GIT1-independent, mechanism must exist for utilizing glycerophosphoinositol as a phosphate source at physiological pH (PubMed:21984707, PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:21984707). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:21984707, PubMed:24114876).
messages: Phosphate levels regulate glycerophosphoinositol transport activity and transcription factor PHO4 is required for GIT1 expression (PubMed:21984707). Expression profile differs significantly in isolates of high, medium, and low virulence, being the highest in the most virulent strains (PubMed:19151328).

237561:CAALFM C402190CA
gene id: 237561:CAALFM_C402190CA
uniprot id: Q5AMS5
names: Similarity
messages: Belongs to the CoA-transferase III family.

237561:CAALFM CR01070WA
gene id: 237561:CAALFM_CR01070WA
uniprot id: Q5A880
names: Similarity
messages: Belongs to the nudE family.

237561:CAALFM C604130CA
gene id: 237561:CAALFM_C604130CA
uniprot id: A0A1D8PQB9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.
messages: N-glycosylated and O-glycosylated.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C400200CA
gene id: 237561:CAALFM_C400200CA
uniprot id: Q59US5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

237561:CAALFM C504070CA
gene id: 237561:CAALFM_C504070CA
uniprot id: Q59LQ4
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

237561:CAALFM C305380WA
gene id: 237561:CAALFM_C305380WA
uniprot id: A0A1D8PK68
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C209520CA
gene id: 237561:CAALFM_C209520CA
uniprot id: Q59YC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

237561:CAALFM C404070CA
gene id: 237561:CAALFM_C404070CA
uniprot id: Q5A5U6
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment.
messages: cell wall

237561:CAALFM CR08360CA
gene id: 237561:CAALFM_CR08360CA
uniprot id: A0A1D8PTS0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

237561:CAALFM C603480WA
gene id: 237561:CAALFM_C603480WA
uniprot id: A0A1D8PQ66
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

237561:CAALFM C103040WA
gene id: 237561:CAALFM_C103040WA
uniprot id: Q5AI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LOT5 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C701810WA
gene id: 237561:CAALFM_C701810WA
uniprot id: Q5AGZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

237561:CAALFM C104070CA
gene id: 237561:CAALFM_C104070CA
uniprot id: A0A1D8PD57
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

237561:CAALFM C307250WA
gene id: 237561:CAALFM_C307250WA
uniprot id: Q5ADR6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

237561:CAALFM C201440CA
gene id: 237561:CAALFM_C201440CA
uniprot id: A0A1D8PGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
messages: cytoskeleton
messages: nuclear pore complex

237561:CAALFM C402070WA
gene id: 237561:CAALFM_C402070WA
uniprot id: Q5AMR2
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

237561:CAALFM C400440CA
gene id: 237561:CAALFM_C400440CA
uniprot id: A0A1D8PL16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C306190CA
gene id: 237561:CAALFM_C306190CA
uniprot id: Q5A2Z7
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.
messages: Highly expressed in biofilms and during candidiasis infection dissemination. Induced upon interaction with host macrophages.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C206360CA
gene id: 237561:CAALFM_C206360CA
uniprot id: Q59P36
names: Similarity
messages: Belongs to the MAK16 family.

237561:CAALFM C114320CA
gene id: 237561:CAALFM_C114320CA
uniprot id: A0A1D8PFV6
names: Similarity
messages: Belongs to the FAH family.

237561:CAALFM C701200CA
gene id: 237561:CAALFM_C701200CA
uniprot id: Q59S50
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C502320CA
gene id: 237561:CAALFM_C502320CA
uniprot id: Q5AGD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C400340WA
gene id: 237561:CAALFM_C400340WA
uniprot id: A0A1D8PL06
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM C303360WA
gene id: 237561:CAALFM_C303360WA
uniprot id: A0A1D8PJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM C102760WA
gene id: 237561:CAALFM_C102760WA
uniprot id: P0CB54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.

237561:CAALFM C108000WA
gene id: 237561:CAALFM_C108000WA
uniprot id: Q5A791
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR04450CA
gene id: 237561:CAALFM_CR04450CA
uniprot id: A0A1D8PSS1
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

237561:CAALFM C501470CA
gene id: 237561:CAALFM_C501470CA
uniprot id: A0A1D8PN64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C503950WA
gene id: 237561:CAALFM_C503950WA
uniprot id: A0A1D8PNU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C106010WA
gene id: 237561:CAALFM_C106010WA
uniprot id: Q5AA40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Interacts with CHS3.

237561:CAALFM C700710WA
gene id: 237561:CAALFM_C700710WA
uniprot id: A0A1D8PQN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C403360CA
gene id: 237561:CAALFM_C403360CA
uniprot id: Q59PH5
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C206460WA
gene id: 237561:CAALFM_C206460WA
uniprot id: A0A1D8PHN5
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

237561:CAALFM C300980WA
gene id: 237561:CAALFM_C300980WA
uniprot id: A0A1D8PJ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

237561:CAALFM C601280WA
gene id: 237561:CAALFM_C601280WA
uniprot id: Q59XM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex.
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
messages: secretory vesicle

237561:CAALFM C702160WA
gene id: 237561:CAALFM_C702160WA
uniprot id: A0A1D8PR19
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C301430WA
gene id: 237561:CAALFM_C301430WA
uniprot id: Q5AJ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRT14 family.
messages: Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
messages: nucleolus

237561:CAALFM C102660CA
gene id: 237561:CAALFM_C102660CA
uniprot id: Q5AI97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity).
messages: mitochondrion nucleoid

237561:CAALFM C407200CA
gene id: 237561:CAALFM_C407200CA
uniprot id: A0A1D8PMT0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00210WA
gene id: 237561:CAALFM_CR00210WA
uniprot id: A0A1D8PRN7
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM C103360WA
gene id: 237561:CAALFM_C103360WA
uniprot id: A0A1D8PCZ6
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C104500WA
gene id: 237561:CAALFM_C104500WA
uniprot id: Q59RB8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

237561:CAALFM C110020WA
gene id: 237561:CAALFM_C110020WA
uniprot id: Q5AP95
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repressed by the HAP43 transcription regulator. Expression is also under the control of MAC1.
messages: Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice.

237561:CAALFM C503110CA
gene id: 237561:CAALFM_C503110CA
uniprot id: A0A1D8PNM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

237561:CAALFM C107000WA
gene id: 237561:CAALFM_C107000WA
uniprot id: Q5AAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

237561:CAALFM C501340WA
gene id: 237561:CAALFM_C501340WA
uniprot id: Q5A1W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
messages: Nucleus

237561:CAALFM C601690WA
gene id: 237561:CAALFM_C601690WA
uniprot id: A0A1D8PPP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

237561:CAALFM C701890CA
gene id: 237561:CAALFM_C701890CA
uniprot id: A0A1D8PQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

237561:CAALFM C207200WA
gene id: 237561:CAALFM_C207200WA
uniprot id: Q59Z24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

237561:CAALFM C205930WA
gene id: 237561:CAALFM_C205930WA
uniprot id: A0A1D8PHI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C110010CA
gene id: 237561:CAALFM_C110010CA
uniprot id: Q5AP97
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Bud neck
messages: Leads to hypersensitivity to caspofungin.
messages: Nucleus
messages: Phosphorylated.
messages: Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth.

237561:CAALFM C600600CA
gene id: 237561:CAALFM_C600600CA
uniprot id: Q59NH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM CR10520CA
gene id: 237561:CAALFM_CR10520CA
uniprot id: A0A1D8PU96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

237561:CAALFM C300900CA
gene id: 237561:CAALFM_C300900CA
uniprot id: A0A1D8PJ12
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C501960CA
gene id: 237561:CAALFM_C501960CA
uniprot id: A0A1D8PNB3
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

237561:CAALFM C105990CA
gene id: 237561:CAALFM_C105990CA
uniprot id: Q5AA38
names: Similarity
messages: Belongs to the ketopantoate reductase family.

237561:CAALFM C400510CA
gene id: 237561:CAALFM_C400510CA
uniprot id: Q59SI1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

237561:CAALFM C301170WA
gene id: 237561:CAALFM_C301170WA
uniprot id: Q59L25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

237561:CAALFM C405230CA
gene id: 237561:CAALFM_C405230CA
uniprot id: Q59RA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIX1/PELP1 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

237561:CAALFM C602050WA
gene id: 237561:CAALFM_C602050WA
uniprot id: A0A1D8PPT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

237561:CAALFM C300850CA
gene id: 237561:CAALFM_C300850CA
uniprot id: A0A1D8PJ10
names: Similarity
messages: Belongs to the EIS1 family.

237561:CAALFM CR01930CA
gene id: 237561:CAALFM_CR01930CA
uniprot id: A0A1D8PS33
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

237561:CAALFM C700970CA
gene id: 237561:CAALFM_C700970CA
uniprot id: A0A1D8PQR5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C301940CA
gene id: 237561:CAALFM_C301940CA
uniprot id: A0A1D8PJB6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C105620CA
gene id: 237561:CAALFM_C105620CA
uniprot id: Q5A9Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane

237561:CAALFM C201060CA
gene id: 237561:CAALFM_C201060CA
uniprot id: Q5AD49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH4 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
messages: The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

237561:CAALFM C104280CA
gene id: 237561:CAALFM_C104280CA
uniprot id: Q59VN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).

237561:CAALFM CR02190CA
gene id: 237561:CAALFM_CR02190CA
uniprot id: Q59UY7
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expression is regulated by changes of iron conditions with an increase in low iron. Transcription is negatively regulated by SFU1.
messages: Interacts with SSN3 and SFU1.
messages: Nucleus
messages: Phosphorylated by SSN3 under iron-depleted conditions which leads to nuclear localization.
messages: Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection.

237561:CAALFM C505140WA
gene id: 237561:CAALFM_C505140WA
uniprot id: A0A1D8PP61
names: Similarity
messages: Belongs to the ketopantoate reductase family.

237561:CAALFM C106080CA
gene id: 237561:CAALFM_C106080CA
uniprot id: Q5AA47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

237561:CAALFM C300860WA
gene id: 237561:CAALFM_C300860WA
uniprot id: Q59LN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
messages: Nucleus
messages: Ubiquitinated. Is degraded through ubiquitin-mediated proteolysis when not protected by its association to the kinetochore.
messages: centromere

237561:CAALFM C604610CA
gene id: 237561:CAALFM_C604610CA
uniprot id: A0A1D8PQG0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: Cell membrane
messages: Expression is induced in presence of cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline (PubMed:12589826). Expression is up-regulated during biofilm formation (PubMed:25784162). Expression is also increased in high-iron conditions (PubMed:15387822). Expression is decreased after combined treatment with fluconazole and osthole (PubMed:28607012).
messages: Leads to increased susceptibility to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, but not to actinomycin D, fluconazole, ketoconazole and colchicine (PubMed:12076781). Leads also to attenuated virulence in mice (PubMed:12076781).
messages: MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake (PubMed:19648376). Confers resistance to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence (PubMed:12076781, PubMed:12589826).

237561:CAALFM C300490WA
gene id: 237561:CAALFM_C300490WA
uniprot id: Q5A7Q2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-296 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
messages: Chromosome
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

237561:CAALFM C603630WA
gene id: 237561:CAALFM_C603630WA
uniprot id: A0A1D8PQ84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Mitochondrion
messages: Oligomer.

237561:CAALFM C113830CA
gene id: 237561:CAALFM_C113830CA
uniprot id: Q5AKV6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

237561:CAALFM C503010WA
gene id: 237561:CAALFM_C503010WA
uniprot id: A0A1D8PNL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

237561:CAALFM C404990CA
gene id: 237561:CAALFM_C404990CA
uniprot id: A0A1D8PM72
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C701840WA
gene id: 237561:CAALFM_C701840WA
uniprot id: Q5AH02
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Bud neck
messages: Hyperphosphorylated. Phosphorylation is cell cycle-dependent and peaks at the time of cytokinesis. Contains 21 consensus sites for cyclin-dependent kinases (CDKs). At least some of them are phosphorylated by the CLB2-CDC28 kinase complex. Mutation of 15 of the phosphorylation sites to Ala caused both premature assembly and delayed disassembly of the actomyosin ring, blocked interaction with the actin-nucleating proteins BNI1 and BNR1, and resulted in defects in cytokinesis.
messages: Interacts with myosin MYO1 and its light chain MLC1 (By similarity). Interacts with BNI1 (PubMed:18923418). Interacts with BNR1 (PubMed:18923418). Interacts with CLB2 (PubMed:18923418). Interacts with CLB4 (PubMed:18923418). Interacts with CDC28 (PubMed:18923418).
messages: Rat catheter biofilm repressed.
messages: Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis.
messages: The IQ domains provide the interaction surface for the myosin light chain MLC1.
messages: The Ras-GAP domain is required for contraction of the actomyosin ring. It probably does not stimulate GTPase activity (By similarity).
messages: The calponin homology (CH) domain binds to actin filaments and is required for their recruitment to the bud neck.

237561:CAALFM C205190WA
gene id: 237561:CAALFM_C205190WA
uniprot id: P12461
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase family.
messages: Homodimer.

237561:CAALFM C501310WA
gene id: 237561:CAALFM_C501310WA
uniprot id: A0A1D8PN50
names: Function
names: Similarity
messages: Belongs to the SNU71 family.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.

237561:CAALFM CR07230WA
gene id: 237561:CAALFM_CR07230WA
uniprot id: Q59RN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B (By similarity).
messages: Nucleus

237561:CAALFM CR01100CA
gene id: 237561:CAALFM_CR01100CA
uniprot id: Q5A884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX23 family.
messages: Mitochondrion intermembrane space
messages: Required for the assembly of cytochrome c oxidase.

237561:CAALFM C601390WA
gene id: 237561:CAALFM_C601390WA
uniprot id: A0A1D8PPM7
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

237561:CAALFM C703380WA
gene id: 237561:CAALFM_C703380WA
uniprot id: A0A1D8PRB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

237561:CAALFM C108180CA
gene id: 237561:CAALFM_C108180CA
uniprot id: A0A1D8PE79
names: Similarity
messages: Belongs to the OSBP family.

237561:CAALFM C404250WA
gene id: 237561:CAALFM_C404250WA
uniprot id: Q59P92
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR06800CA
gene id: 237561:CAALFM_CR06800CA
uniprot id: Q59VN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

237561:CAALFM CR00540CA
gene id: 237561:CAALFM_CR00540CA
uniprot id: P83778
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Homodimer.

237561:CAALFM C703360WA
gene id: 237561:CAALFM_C703360WA
uniprot id: A0A1D8PRC2
names: Similarity
messages: Belongs to the peptidase S10 family.

237561:CAALFM C104290CA
gene id: 237561:CAALFM_C104290CA
uniprot id: Q8NJN3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

237561:CAALFM C206440CA
gene id: 237561:CAALFM_C206440CA
uniprot id: Q59Q42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

237561:CAALFM C304740CA
gene id: 237561:CAALFM_C304740CA
uniprot id: Q5ANG9
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

237561:CAALFM C107170CA
gene id: 237561:CAALFM_C107170CA
uniprot id: Q59WB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Nucleus
messages: Transcription factor which regulates nonfermentable carbon utilization.

237561:CAALFM C703720CA
gene id: 237561:CAALFM_C703720CA
uniprot id: A0A1D8PRE9
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

237561:CAALFM C206960WA
gene id: 237561:CAALFM_C206960WA
uniprot id: Q59Z50
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

237561:CAALFM C102880CA
gene id: 237561:CAALFM_C102880CA
uniprot id: O94030
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cu(2+) or Zn(2+).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

237561:CAALFM C108020WA
gene id: 237561:CAALFM_C108020WA
uniprot id: A0A1D8PE77
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

237561:CAALFM C702510WA
gene id: 237561:CAALFM_C702510WA
uniprot id: A0A1D8PR50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

237561:CAALFM C400790CA
gene id: 237561:CAALFM_C400790CA
uniprot id: Q59SL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

237561:CAALFM C306230WA
gene id: 237561:CAALFM_C306230WA
uniprot id: Q5A301
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

237561:CAALFM C106800WA
gene id: 237561:CAALFM_C106800WA
uniprot id: Q5AAT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity).
messages: Divalent metal cation.
messages: Nucleus

237561:CAALFM C207190CA
gene id: 237561:CAALFM_C207190CA
uniprot id: Q59Z25
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

237561:CAALFM CR03970CA
gene id: 237561:CAALFM_CR03970CA
uniprot id: A0A1D8PSL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR02920CA
gene id: 237561:CAALFM_CR02920CA
uniprot id: Q5A1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR04900CA
gene id: 237561:CAALFM_CR04900CA
uniprot id: Q59N10
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM CR01980CA
gene id: 237561:CAALFM_CR01980CA
uniprot id: Q5A967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C100400WA
gene id: 237561:CAALFM_C100400WA
uniprot id: Q5ABA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: cis-Golgi network membrane

237561:CAALFM C400320CA
gene id: 237561:CAALFM_C400320CA
uniprot id: A0A1D8PL05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

237561:CAALFM C208010WA
gene id: 237561:CAALFM_C208010WA
uniprot id: Q5A2T3
names: Similarity
messages: Belongs to the BLM10 family.

237561:CAALFM C601030WA
gene id: 237561:CAALFM_C601030WA
uniprot id: Q59XQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance (By similarity).

237561:CAALFM C209300WA
gene id: 237561:CAALFM_C209300WA
uniprot id: Q59X40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C207580WA
gene id: 237561:CAALFM_C207580WA
uniprot id: A0A1D8PHX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

237561:CAALFM C110810WA
gene id: 237561:CAALFM_C110810WA
uniprot id: Q59WG5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Expression is higher in white cells.
messages: Secreted
messages: Secreted protein that acts as a virulence factor during infections.

237561:CAALFM C604380WA
gene id: 237561:CAALFM_C604380WA
uniprot id: P0CU38
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.
messages: Highly expressed in biofilms with down-regulation during later stages of biofilm formation. Expression is repressed by TPK1 and SFL1, and induced by TPK2. Also under the control of TOR1. Expression is down-regulated by Riccardin D, a macrocyclic bisbibenzyl isolated from Chinese liverwort D.hirsute, which has an inhibitory effect on biofilms and virulence. Induced by caspofungin.
messages: N-glycosylated and O-glycosylated.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C202090WA
gene id: 237561:CAALFM_C202090WA
uniprot id: Q5AM50
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in nonsense-mediated decay of mRNAs containing premature stop codons.

237561:CAALFM C403700WA
gene id: 237561:CAALFM_C403700WA
uniprot id: A0A1D8PLV7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C300250CA
gene id: 237561:CAALFM_C300250CA
uniprot id: Q5A7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

237561:CAALFM C107040CA
gene id: 237561:CAALFM_C107040CA
uniprot id: Q5AB49
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Induced in hyphae and up-regulated during oral infection. Expression is higher in white cells.
messages: Secreted
messages: Secreted protein that acts as a virulence factor during infections.
messages: reduces capacity to damage oral epithelial cells.

237561:CAALFM C104670WA
gene id: 237561:CAALFM_C104670WA
uniprot id: Q59VF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C602290CA
gene id: 237561:CAALFM_C602290CA
uniprot id: A0A1D8PPU8
names: Similarity
messages: Belongs to the TYW1 family.

237561:CAALFM C501800CA
gene id: 237561:CAALFM_C501800CA
uniprot id: A0A1D8PN88
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease that is able to transport phenylalanine (PubMed:21764911, PubMed:28028545).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is also regulated by PLC1 and GCN4 (PubMed:16207920, PubMed:16215176). Expression is induced during development of biofilm (PubMed:22265407).

237561:CAALFM C402980WA
gene id: 237561:CAALFM_C402980WA
uniprot id: Q5AFB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

237561:CAALFM C201820CA
gene id: 237561:CAALFM_C201820CA
uniprot id: Q5AM84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNU71 family.
messages: Component of the U1 snRNP particle, a subcomplex of the spliceosome.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity).
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C302620CA
gene id: 237561:CAALFM_C302620CA
uniprot id: A0A1D8PJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C603560WA
gene id: 237561:CAALFM_C603560WA
uniprot id: A0A1D8PQ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

237561:CAALFM C101840CA
gene id: 237561:CAALFM_C101840CA
uniprot id: Q59T92
names: Similarity
messages: Belongs to the Rho GDI family.

237561:CAALFM C700960WA
gene id: 237561:CAALFM_C700960WA
uniprot id: A0A1D8PQQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C105190CA
gene id: 237561:CAALFM_C105190CA
uniprot id: A0A1D8PDI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

237561:CAALFM C504300CA
gene id: 237561:CAALFM_C504300CA
uniprot id: Q5AKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides (By similarity).
messages: Cytoplasm
messages: Homodimer. Component of the GSH degradosomal complex.

237561:CAALFM C406790WA
gene id: 237561:CAALFM_C406790WA
uniprot id: Q5A0W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

237561:CAALFM C400660WA
gene id: 237561:CAALFM_C400660WA
uniprot id: Q59SJ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

237561:CAALFM C500240WA
gene id: 237561:CAALFM_C500240WA
uniprot id: Q5A4X5
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKN7 family.
messages: Homotrimer.
messages: Homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity.
messages: Leads to sensitivity to H(2)O(2) in vitro, but only mildly attenuated virulence.
messages: Nucleus
messages: Phosphorylated by the phosphorelay intermediate protein YPD1.
messages: Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.

237561:CAALFM C300530CA
gene id: 237561:CAALFM_C300530CA
uniprot id: Q5A7Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
messages: Self-associates. Interacts with NDL1 and dynein.
messages: cytoskeleton
messages: spindle pole

237561:CAALFM C500220WA
gene id: 237561:CAALFM_C500220WA
uniprot id: Q5A4X3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

237561:CAALFM C210860CA
gene id: 237561:CAALFM_C210860CA
uniprot id: Q5A5N0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

237561:CAALFM C500050WA
gene id: 237561:CAALFM_C500050WA
uniprot id: A0A1D8PMU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP5 family.
messages: Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.
messages: Mitochondrion

237561:CAALFM C403680CA
gene id: 237561:CAALFM_C403680CA
uniprot id: A0A1D8PLW0
names: Similarity
messages: Belongs to the XPC family.

237561:CAALFM C103790CA
gene id: 237561:CAALFM_C103790CA
uniprot id: Q59VR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: nucleolus

237561:CAALFM C200960CA
gene id: 237561:CAALFM_C200960CA
uniprot id: Q5AD39
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

237561:CAALFM C107970CA
gene id: 237561:CAALFM_C107970CA
uniprot id: A0A1D8PE76
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR09800CA
gene id: 237561:CAALFM_CR09800CA
uniprot id: A0A1D8PU27
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C113420CA
gene id: 237561:CAALFM_C113420CA
uniprot id: A0A1D8PFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.

237561:CAALFM C603950CA
gene id: 237561:CAALFM_C603950CA
uniprot id: Q5A8H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Nucleus

237561:CAALFM C600790CA
gene id: 237561:CAALFM_C600790CA
uniprot id: Q59NP1
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Expressed in limited copper conditions. Expression is positively controlled by MAC1 and TYE7. Induced during biofilm formation and contact with macrophages as well as by alkaline pH via RIM101. Expression is down-regulated by 17-beta-estradiol.
messages: Impairs growth on solid low-copper and low-iron medium and displays altered morphology in response to copper-depleted conditions.
messages: Oligomer.
messages: Required for high affinity copper (probably reduced Cu I) transport into the cell.

237561:CAALFM C204230WA
gene id: 237561:CAALFM_C204230WA
uniprot id: A0A1D8PH42
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C700530CA
gene id: 237561:CAALFM_C700530CA
uniprot id: Q5AFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

237561:CAALFM C401120CA
gene id: 237561:CAALFM_C401120CA
uniprot id: A0A1D8PLB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

237561:CAALFM C200550WA
gene id: 237561:CAALFM_C200550WA
uniprot id: Q5ACZ5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C100170WA
gene id: 237561:CAALFM_C100170WA
uniprot id: Q5AB86
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

237561:CAALFM C110770WA
gene id: 237561:CAALFM_C110770WA
uniprot id: A0A1D8PEY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

237561:CAALFM CR00200WA
gene id: 237561:CAALFM_CR00200WA
uniprot id: A0A1D8PRM7
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

237561:CAALFM C404520WA
gene id: 237561:CAALFM_C404520WA
uniprot id: Q5A660
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PINX1 family.
messages: Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
messages: nucleolus

237561:CAALFM C600360CA
gene id: 237561:CAALFM_C600360CA
uniprot id: A0A1D8PPE1
names: Similarity
messages: Belongs to the MIX23 family.

237561:CAALFM C201480WA
gene id: 237561:CAALFM_C201480WA
uniprot id: Q5ALX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).

237561:CAALFM C202350CA
gene id: 237561:CAALFM_C202350CA
uniprot id: A0A1D8PGL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAC3 family.
messages: Nucleus envelope

237561:CAALFM C208610WA
gene id: 237561:CAALFM_C208610WA
uniprot id: A0A1D8PI71
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Endoplasmic reticulum membrane
messages: Expression is induced by lovastatin and fluconazole and is repressed by amphotericin B and caspofungin (PubMed:14653518). Expression is repressed during spider biofilm formation (PubMed:22265407).
messages: Microsome
messages: Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help an…

237561:CAALFM CR04340WA
gene id: 237561:CAALFM_CR04340WA
uniprot id: Q5A6N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

237561:CAALFM C301930WA
gene id: 237561:CAALFM_C301930WA
uniprot id: Q5AJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

237561:CAALFM C401690CA
gene id: 237561:CAALFM_C401690CA
uniprot id: A0A1D8PLC6
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

237561:CAALFM CR10820WA
gene id: 237561:CAALFM_CR10820WA
uniprot id: A0A1D8PUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

237561:CAALFM C602040WA
gene id: 237561:CAALFM_C602040WA
uniprot id: Q59M70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: May mediate the reduction of outer membrane cytochrome b5.
messages: Mitochondrion outer membrane

237561:CAALFM C114000CA
gene id: 237561:CAALFM_C114000CA
uniprot id: A0A1D8PFU3
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM CR02090CA
gene id: 237561:CAALFM_CR02090CA
uniprot id: O93803
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

237561:CAALFM C307160WA
gene id: 237561:CAALFM_C307160WA
uniprot id: Q5ADQ7
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Induced upon high iron conditions.
messages: Putative adhesin which is involved in cell adhesion and virulence.

237561:CAALFM C602180WA
gene id: 237561:CAALFM_C602180WA
uniprot id: A0A1D8PPU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

237561:CAALFM C502730CA
gene id: 237561:CAALFM_C502730CA
uniprot id: Q5AG86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Cytoplasm
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Interacts with NAR1.
messages: Nucleus

237561:CAALFM C113790CA
gene id: 237561:CAALFM_C113790CA
uniprot id: Q5AKW1
names: Similarity
messages: Belongs to the BolA/IbaG family.

237561:CAALFM C111370CA
gene id: 237561:CAALFM_C111370CA
uniprot id: A0A1D8PF46
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C406820CA
gene id: 237561:CAALFM_C406820CA
uniprot id: Q5A0W9
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with EFG1.
messages: Nucleus
messages: Regulated in response to carbon source, temperature, growth phase, and physical environment. Expression is up-regulated by rapamycine, and thus is under the regulation of the TOR pathway. Binds its own promoter and is also under the control of EFG1.
messages: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor of beta-glucan synthesis, thus negatively regulating cell wall integrity. Plays a role in adherence, invasion and damage to oral epithelial cells.

237561:CAALFM C306170CA
gene id: 237561:CAALFM_C306170CA
uniprot id: A0A1D8PKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C102350WA
gene id: 237561:CAALFM_C102350WA
uniprot id: Q59VW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C208730WA
gene id: 237561:CAALFM_C208730WA
uniprot id: Q59Y46
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MFG1 family.
messages: Defective in filamentation and invasive growth in response to environmental cues. Defective in the formation of biofilms. Displays decreased virulence in the greater wax moth Galleria mellonella infection model.
messages: Interacts with FLO8 and MSS11, both morphogenetic transcription factors binding directly to the FLO11 promoter.
messages: Nucleus
messages: Transcriptional regulator with a general role in all morphogenetically distinct forms of filamentous growth, namely invasive growth and biofilm formation. May control FLO11 gene expression as part of a promoter-bound complex with FLO8 and MSS1. Important for virulence.

237561:CAALFM CR08860WA
gene id: 237561:CAALFM_CR08860WA
uniprot id: A0A1D8PTU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

237561:CAALFM C702300WA
gene id: 237561:CAALFM_C702300WA
uniprot id: Q5AH56
names: Similarity
messages: Belongs to the peptidase A1 family.

237561:CAALFM C112680WA
gene id: 237561:CAALFM_C112680WA
uniprot id: A0A1D8PFH2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C112960CA
gene id: 237561:CAALFM_C112960CA
uniprot id: Q5AL52
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the formin homology family. BNI1 subfamily.
messages: Bud neck
messages: Bud tip
messages: Cell septum
messages: Homodimer, and possibly also homotetramer (By similarity). Interacts with actin via the FH2 domain (By similarity). Interacts with IQG1.
messages: Leads to swollen cells, increased random budding pattern, and severe defect in cytokinesis with enlarged bud necks.
messages: Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioning the Golgi complex to a putative site of germ tube emergence and for coordinating the transport and deposition of membrane and cell wall material to a growing hypha. Plays a key role in virulence.
messages: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
messages: cytoskeleton

237561:CAALFM C404210CA
gene id: 237561:CAALFM_C404210CA
uniprot id: Q59P87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C304900WA
gene id: 237561:CAALFM_C304900WA
uniprot id: Q5ANE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

237561:CAALFM C304220CA
gene id: 237561:CAALFM_C304220CA
uniprot id: Q5ANN6
names: Similarity
messages: Belongs to the uridine kinase family.

237561:CAALFM C107110WA
gene id: 237561:CAALFM_C107110WA
uniprot id: A0A1D8PE08
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C200070CA
gene id: 237561:CAALFM_C200070CA
uniprot id: A0A1D8PFZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

237561:CAALFM C100750CA
gene id: 237561:CAALFM_C100750CA
uniprot id: Q5ABD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Both IUM domains are necessary for efficient binding to ubiquitin.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.

237561:CAALFM C208940CA
gene id: 237561:CAALFM_C208940CA
uniprot id: Q59SD1
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

237561:CAALFM C406270CA
gene id: 237561:CAALFM_C406270CA
uniprot id: Q5A1B0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Expression is repressed by amphotericin B and caspofungin (PubMed:15917516). Expression is also repressed during biofilm formation (PubMed:22265407).
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).
messages: Impairs growth.
messages: Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:12702354). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:12702354). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-be…

237561:CAALFM C205050CA
gene id: 237561:CAALFM_C205050CA
uniprot id: Q59ZI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GNT1 family.
messages: Golgi apparatus membrane
messages: N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
messages: Vacuole membrane

237561:CAALFM C306380WA
gene id: 237561:CAALFM_C306380WA
uniprot id: P0CU36
uniprot id: Q5A2Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
messages: nucleolus

237561:CAALFM C113940WA
gene id: 237561:CAALFM_C113940WA
uniprot id: Q5AKU5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Cell surface beta-glucosidase involved in cell wall maintenance and cytokinesis. Plays a role redundant to SUN41.
messages: Expression is up-regulated during biofilm formation and down-regulated by RIM101, CYR1, RAS1, as well as by host macrophages.
messages: cell wall

237561:CAALFM C305900WA
gene id: 237561:CAALFM_C305900WA
uniprot id: A0A1D8PKJ0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C400120WA
gene id: 237561:CAALFM_C400120WA
uniprot id: Q59UT5
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: Cell membrane
messages: GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization (PubMed:25275454, PubMed:27617569). Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade (PubMed:25275454, PubMed:27617569). The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation (PubMed:25275454).
messages: Induced by hypoxia, ketoconazole, fluconazole, nitric oxide, ciclopirox olamine, during cell wall regeneration following protoplasting, during adhesion, and during biofilm formation. Regulated by UPC2, BCR1, HAP43, and RIM101.
messages: Interacts with RBT5.
messages: Leads to defects in hemoglobin utilization as sole source of iron and decreased virulence on a mouse model of systemic candidiasis.
messages: The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (PubMed:12633989, PubMed:22145027, PubMed:25275454). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C601970CA
gene id: 237561:CAALFM_C601970CA
uniprot id: A0A1D8PPS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL25 is a major component of the universal docking site for these factors at the polypeptide exit tunnel (By similarity).
messages: Cytoplasm

237561:CAALFM CR04100CA
gene id: 237561:CAALFM_CR04100CA
uniprot id: Q5A6R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C113640WA
gene id: 237561:CAALFM_C113640WA
uniprot id: Q5AKX6
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C302510CA
gene id: 237561:CAALFM_C302510CA
uniprot id: Q5AEM6
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Serves as a major regulator of MSB2-processing which activates CEK1 MAPK-signaling affecting biofilm formation and oropharyngeal candidiasis. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C406950WA
gene id: 237561:CAALFM_C406950WA
uniprot id: Q5A0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase RluA family.
messages: Mitochondrion
messages: Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.

237561:CAALFM CR04530WA
gene id: 237561:CAALFM_CR04530WA
uniprot id: Q5A6L1
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

237561:CAALFM CR07270CA
gene id: 237561:CAALFM_CR07270CA
uniprot id: A0A1D8PTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C110820CA
gene id: 237561:CAALFM_C110820CA
uniprot id: Q59WG6
names: Similarity
messages: Belongs to the peptidase M18 family.

237561:CAALFM C503960WA
gene id: 237561:CAALFM_C503960WA
uniprot id: Q59MK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

237561:CAALFM C106100CA
gene id: 237561:CAALFM_C106100CA
uniprot id: Q96VB9
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Interacts with CGR1.

237561:CAALFM C203680WA
gene id: 237561:CAALFM_C203680WA
uniprot id: A0A1D8PGX5
names: Similarity
messages: Belongs to the peptidase A1 family.

237561:CAALFM C102050CA
gene id: 237561:CAALFM_C102050CA
uniprot id: Q59VZ6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C114190CA
gene id: 237561:CAALFM_C114190CA
uniprot id: Q59ZW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

237561:CAALFM C209840WA
gene id: 237561:CAALFM_C209840WA
uniprot id: Q59YF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

237561:CAALFM C114350WA
gene id: 237561:CAALFM_C114350WA
uniprot id: Q59ZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

237561:CAALFM C503540CA
gene id: 237561:CAALFM_C503540CA
uniprot id: A0A1D8PNQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C203770CA
gene id: 237561:CAALFM_C203770CA
uniprot id: A0A1D8PGY4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

237561:CAALFM C210820CA
gene id: 237561:CAALFM_C210820CA
uniprot id: A0A1D8PIS7
names: Similarity
messages: Belongs to the THADA family.

237561:CAALFM C500680WA
gene id: 237561:CAALFM_C500680WA
uniprot id: A0A1D8PMZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

237561:CAALFM C702570CA
gene id: 237561:CAALFM_C702570CA
uniprot id: P28870
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Cytoplasm
messages: Inhibited by rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C208420WA
gene id: 237561:CAALFM_C208420WA
uniprot id: A0A1D8PI96
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

237561:CAALFM C307390CA
gene id: 237561:CAALFM_C307390CA
uniprot id: Q5ADT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU).
messages: Mitochondrion

237561:CAALFM C109710CA
gene id: 237561:CAALFM_C109710CA
uniprot id: Q5APD0
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C105080WA
gene id: 237561:CAALFM_C105080WA
uniprot id: A0A1D8PDH1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C202120WA
gene id: 237561:CAALFM_C202120WA
uniprot id: Q5ALP7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.

237561:CAALFM C306180CA
gene id: 237561:CAALFM_C306180CA
uniprot id: P0CU34
uniprot id: Q9Y7F0
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cell surface
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation.
messages: Induced by oxidative stress.
messages: Nucleus
messages: Results in delayed hyphal development and enhanced sensitivity to cell wall-perturbing agents, yet does not impair virulence in vivo.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.

237561:CAALFM C407230CA
gene id: 237561:CAALFM_C407230CA
uniprot id: Q5A119
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

237561:CAALFM CR07580CA
gene id: 237561:CAALFM_CR07580CA
uniprot id: A0A1D8PTJ4
names: Similarity
messages: Belongs to the RICTOR family.

237561:CAALFM C307950CA
gene id: 237561:CAALFM_C307950CA
uniprot id: O93827
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).

237561:CAALFM C300700WA
gene id: 237561:CAALFM_C300700WA
uniprot id: A0A1D8PJ06
names: Similarity
messages: Belongs to the VPS8 family.

237561:CAALFM C602770WA
gene id: 237561:CAALFM_C602770WA
uniprot id: Q5AC00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

237561:CAALFM C203350WA
gene id: 237561:CAALFM_C203350WA
uniprot id: Q5AHA4
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Predicted GPI-anchored protein which may have a role during host infection.
messages: Substrate for cleavage by KEX2 in vitro.
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment, upon interaction of cells with host macrophages, and during oralpharyngeal candidiasis. Repressed by alpha pheromone.

237561:CAALFM C205230CA
gene id: 237561:CAALFM_C205230CA
uniprot id: Q59ZG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

237561:CAALFM C209730CA
gene id: 237561:CAALFM_C209730CA
uniprot id: Q59YE9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

237561:CAALFM C100440WA
gene id: 237561:CAALFM_C100440WA
uniprot id: A0A1D8PC77
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM CR04490CA
gene id: 237561:CAALFM_CR04490CA
uniprot id: Q5A6L4
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

237561:CAALFM C111440CA
gene id: 237561:CAALFM_C111440CA
uniprot id: A0A1D8PF47
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C204140WA
gene id: 237561:CAALFM_C204140WA
uniprot id: O74161
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHS5 family.
messages: Golgi apparatus
messages: Involved in chitin synthesis and also required for mating.

237561:CAALFM CR10650WA
gene id: 237561:CAALFM_CR10650WA
uniprot id: A0A1D8PUB0
names: Similarity
messages: Belongs to the LTV1 family.

237561:CAALFM C307350WA
gene id: 237561:CAALFM_C307350WA
uniprot id: Q5ADT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C402770CA
gene id: 237561:CAALFM_C402770CA
uniprot id: Q5AFX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Regulates the cell cycle in a nutrient dependent manner.

237561:CAALFM C111240CA
gene id: 237561:CAALFM_C111240CA
uniprot id: A0A1D8PF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

237561:CAALFM C305650WA
gene id: 237561:CAALFM_C305650WA
uniprot id: A0A1D8PKB4
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C207830WA
gene id: 237561:CAALFM_C207830WA
uniprot id: A0A1D8PI48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

237561:CAALFM C500920WA
gene id: 237561:CAALFM_C500920WA
uniprot id: Q5A1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

237561:CAALFM C109530WA
gene id: 237561:CAALFM_C109530WA
uniprot id: A0A1D8PEN1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

237561:CAALFM C106470WA
gene id: 237561:CAALFM_C106470WA
uniprot id: A0A1D8PDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C301450CA
gene id: 237561:CAALFM_C301450CA
uniprot id: A0A1D8PJ95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

237561:CAALFM C207340WA
gene id: 237561:CAALFM_C207340WA
uniprot id: A0A1D8PI20
names: Similarity
messages: Belongs to the CBF/MAK21 family.

237561:CAALFM C100830WA
gene id: 237561:CAALFM_C100830WA
uniprot id: A0A1D8PCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

237561:CAALFM C204550CA
gene id: 237561:CAALFM_C204550CA
uniprot id: Q59TD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

237561:CAALFM C703300CA
gene id: 237561:CAALFM_C703300CA
uniprot id: Q9P8V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C101810CA
gene id: 237561:CAALFM_C101810CA
uniprot id: Q59T88
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM CR06170WA
gene id: 237561:CAALFM_CR06170WA
uniprot id: A0A1D8PT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

237561:CAALFM CR05570CA
gene id: 237561:CAALFM_CR05570CA
uniprot id: A0A1D8PT08
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

237561:CAALFM C304140CA
gene id: 237561:CAALFM_C304140CA
uniprot id: Q5ANP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

237561:CAALFM C501210WA
gene id: 237561:CAALFM_C501210WA
uniprot id: A0A1D8PN45
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

237561:CAALFM C502020CA
gene id: 237561:CAALFM_C502020CA
uniprot id: A0A1D8PNA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

237561:CAALFM C400040WA
gene id: 237561:CAALFM_C400040WA
uniprot id: A0A1D8PKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

237561:CAALFM C403140CA
gene id: 237561:CAALFM_C403140CA
uniprot id: Q5AFD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM CR01350CA
gene id: 237561:CAALFM_CR01350CA
uniprot id: Q5A9E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

237561:CAALFM C207680WA
gene id: 237561:CAALFM_C207680WA
uniprot id: A0A1D8PHY2
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

237561:CAALFM C402610CA
gene id: 237561:CAALFM_C402610CA
uniprot id: A0A1D8PLL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

237561:CAALFM C101250WA
gene id: 237561:CAALFM_C101250WA
uniprot id: Q5A922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM9 family.
messages: Mitochondrion

237561:CAALFM C109010WA
gene id: 237561:CAALFM_C109010WA
uniprot id: Q5APK7
names: Function
names: Similarity
messages: Belongs to the NARF family.
messages: Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).

237561:CAALFM C101630WA
gene id: 237561:CAALFM_C101630WA
uniprot id: A0A1D8PCJ4
names: Similarity
messages: Belongs to the CIA30 family.

237561:CAALFM C700360WA
gene id: 237561:CAALFM_C700360WA
uniprot id: Q5AFI4
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MID2 like cell wall stress sensor family.
messages: Cell membrane
messages: Cell septum
messages: Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix. Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation. Involved in the maintenance of the cell wall.
messages: Cross-linked to the carbohydrate polymers of the cell wall.
messages: O-glycosylated by MNT1 and MNT2. Also N-glycosylated.
messages: Shows defects in invasion of agar medium and attenuated virulence in a murine model of disseminated candidiasis. Leads to hypersensibility to the glucan synthase inhibitor capsofungin and the cell wall disturbing agents Congo red and calcofluor white.
messages: The GxxxG glycophorin motif in the transmembrane domain is required for CEK1 activation and subsequent invasive filamentation on agar medium.
messages: The cytoplasmic C-terminal calmodulin-binding motif (residues 301 to 317) is important for CEK1 activation and subsequent invasive filamentation on agar medium.
messages: cell wall

237561:CAALFM C502560CA
gene id: 237561:CAALFM_C502560CA
uniprot id: Q5AGB0
names: Subcellular Location Annotation
messages: Secreted

237561:CAALFM C403810WA
gene id: 237561:CAALFM_C403810WA
uniprot id: Q59TN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

237561:CAALFM C206310CA
gene id: 237561:CAALFM_C206310CA
uniprot id: Q59P43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

237561:CAALFM C604650WA
gene id: 237561:CAALFM_C604650WA
uniprot id: Q59RF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Vacuole membrane

237561:CAALFM C103340CA
gene id: 237561:CAALFM_C103340CA
uniprot id: Q5AI21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and SEC72.
messages: Required for preprotein translocation.

237561:CAALFM C113930WA
gene id: 237561:CAALFM_C113930WA
uniprot id: Q5AKU6
names: Disruption Phenotype
names: Function
names: Induction
messages: Expression is detected as early as 1 hour after infection of reconstituted human esophageal tissue and increases thereafter up to 48 hours postinfection.
messages: Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils.
messages: Leads to flocculation, attenuated virulence towards reconstituted human esophageal tissue, and to hypersensitivity to fluconazole and voriconazole.

237561:CAALFM CR01740WA
gene id: 237561:CAALFM_CR01740WA
uniprot id: Q5A995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM CR10760CA
gene id: 237561:CAALFM_CR10760CA
uniprot id: Q5ACH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.

237561:CAALFM C306090CA
gene id: 237561:CAALFM_C306090CA
uniprot id: Q5A4E3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synthesis or phagocytosis by neutrophils.
messages: Results in a temperature-sensitive growth defect, cellular aggregation, loss of outer chain elongation of N-glycans, hypersensitivity to a range of cell wall perturbing agents, as well as to constitutively activated cell wall integrity pathway. Finally, leads to attenuated virulence in a mouse model of systemic infection and affects inflammatory response and the efficiency of neutrophil phagocytosis by the host.
messages: The conserved DXD motif is involved in enzyme activity.

237561:CAALFM C109580CA
gene id: 237561:CAALFM_C109580CA
uniprot id: A0A1D8PER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C111220CA
gene id: 237561:CAALFM_C111220CA
uniprot id: Q59W44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM CR05550CA
gene id: 237561:CAALFM_CR05550CA
uniprot id: Q59M52
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C203910CA
gene id: 237561:CAALFM_C203910CA
uniprot id: A0A1D8PH01
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

237561:CAALFM C702480WA
gene id: 237561:CAALFM_C702480WA
uniprot id: Q5AH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

237561:CAALFM C400450CA
gene id: 237561:CAALFM_C400450CA
uniprot id: Q59UP6
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Cell membrane
messages: Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Involved in biofilm formation.
messages: Induced by RIM101 at pH8, hypoxia, ketoconazole, ciclopirox, and during hyphal growth. Regulated by UPC2 and BCR1.
messages: Mannosylated.
messages: The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (PubMed:12633989). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C103090WA
gene id: 237561:CAALFM_C103090WA
uniprot id: P40910
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

237561:CAALFM CR07300WA
gene id: 237561:CAALFM_CR07300WA
uniprot id: A0A1D8PTF9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C302870CA
gene id: 237561:CAALFM_C302870CA
uniprot id: Q5AEJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C305760WA
gene id: 237561:CAALFM_C305760WA
uniprot id: A0A1D8PKB0
names: Similarity
messages: Belongs to the PPC synthetase family.

237561:CAALFM C202630WA
gene id: 237561:CAALFM_C202630WA
uniprot id: Q5ALI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

237561:CAALFM CR03740CA
gene id: 237561:CAALFM_CR03740CA
uniprot id: Q5A015
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

237561:CAALFM C301350CA
gene id: 237561:CAALFM_C301350CA
uniprot id: P13649
names: Similarity
messages: Belongs to the OMP decarboxylase family.

237561:CAALFM C205460WA
gene id: 237561:CAALFM_C205460WA
uniprot id: P46614
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Cytoplasm
messages: Has antigenic properties.
messages: Homotetramer.

237561:CAALFM C402100CA
gene id: 237561:CAALFM_C402100CA
uniprot id: Q5AMR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).

237561:CAALFM C114260CA
gene id: 237561:CAALFM_C114260CA
uniprot id: Q59ZV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

237561:CAALFM C202230CA
gene id: 237561:CAALFM_C202230CA
uniprot id: A0A1D8PGM5
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C603750CA
gene id: 237561:CAALFM_C603750CA
uniprot id: A0A1D8PQ94
names: Similarity
messages: Belongs to the p23/wos2 family.

237561:CAALFM C107370CA
gene id: 237561:CAALFM_C107370CA
uniprot id: P43079
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus
messages: Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway.

237561:CAALFM C103120WA
gene id: 237561:CAALFM_C103120WA
uniprot id: Q5AI48
names: Subcellular Location Annotation
messages: Vacuole

237561:CAALFM C204460WA
gene id: 237561:CAALFM_C204460WA
uniprot id: Q59TC4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

237561:CAALFM C505160CA
gene id: 237561:CAALFM_C505160CA
uniprot id: A0A1D8PP58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

237561:CAALFM CR05840WA
gene id: 237561:CAALFM_CR05840WA
uniprot id: Q59PT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

237561:CAALFM C601640WA
gene id: 237561:CAALFM_C601640WA
uniprot id: A0A1D8PPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C704250WA
gene id: 237561:CAALFM_C704250WA
uniprot id: A0A1D8PRK9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C111100WA
gene id: 237561:CAALFM_C111100WA
uniprot id: Q59WJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C111050WA
gene id: 237561:CAALFM_C111050WA
uniprot id: A0A1D8PF15
names: Function
names: Similarity
messages: Belongs to the RRT5 family.
messages: May be involved in the modulation of rDNA transcription.

237561:CAALFM C502460CA
gene id: 237561:CAALFM_C502460CA
uniprot id: Q5AGC4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Cell surface protein required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall.
messages: Expression is induced by growth in hypoxic conditions and by caspofungin and ketoconazole. Expression is negatively regulated by BCR1, HOG1, PLC1, RIM101, SSN6, and SUR7.
messages: cell wall

237561:CAALFM C105090WA
gene id: 237561:CAALFM_C105090WA
uniprot id: Q59LX5
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate.
messages: Expression is induced in biofilm.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate.

237561:CAALFM CR05900WA
gene id: 237561:CAALFM_CR05900WA
uniprot id: A0A1D8PT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C603930WA
gene id: 237561:CAALFM_C603930WA
uniprot id: Q5A8H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C300210CA
gene id: 237561:CAALFM_C300210CA
uniprot id: Q5A7L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

237561:CAALFM C106860WA
gene id: 237561:CAALFM_C106860WA
uniprot id: Q5AAT6
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

237561:CAALFM C200500WA
gene id: 237561:CAALFM_C200500WA
uniprot id: A0A1D8PG41
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C210010CA
gene id: 237561:CAALFM_C210010CA
uniprot id: Q59XW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRC22 family.
messages: Endoplasmic reticulum membrane
messages: Is probably involved in a pathway contributing to genomic integrity.

237561:CAALFM C501600CA
gene id: 237561:CAALFM_C501600CA
uniprot id: Q59N29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Component of pre-60S ribosomal complexes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C103800WA
gene id: 237561:CAALFM_C103800WA
uniprot id: A0A1D8PD31
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

237561:CAALFM CR02750CA
gene id: 237561:CAALFM_CR02750CA
uniprot id: Q5A210
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Induced in biofilms and in oralpharyngeal candidasis. Repressed by alpha pheromone.
messages: Predicted GPI-anchored protein which may have a role during host infection.

237561:CAALFM CR02550CA
gene id: 237561:CAALFM_CR02550CA
uniprot id: A0A1D8PS88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

237561:CAALFM C205110WA
gene id: 237561:CAALFM_C205110WA
uniprot id: A0A1D8PHB8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

237561:CAALFM CR03210CA
gene id: 237561:CAALFM_CR03210CA
uniprot id: Q59UG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

237561:CAALFM C501650CA
gene id: 237561:CAALFM_C501650CA
uniprot id: A0A1D8PN92
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

237561:CAALFM C504730CA
gene id: 237561:CAALFM_C504730CA
uniprot id: Q5AK62
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the RNR ribonuclease family.
messages: Constitutively expressed and not cell-cycle regulated like its S.cerevisiae ortholog.
messages: Decreases virulence in murine infection models.
messages: Plays a role in resistance to host antimicrobial peptides such as protamine, RP-1, or human beta-defensin-2; allowing colonization of human tissues. Required for resistance to membrane permeabilization and maintenance of mitochondrial membrane potential upon exposure to RP-1.

237561:CAALFM C501820WA
gene id: 237561:CAALFM_C501820WA
uniprot id: A0A1D8PN90
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C208870CA
gene id: 237561:CAALFM_C208870CA
uniprot id: Q59SF7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Component of the outer cell wall layer required for stability of the cell wall and specifically for cell wall rigidity.
messages: Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
messages: Expression varies during the cell-cycle with a peak at the beginning of G1. Expression increases in hypoxic and acidic conditions and is down-regulated during the switch from yeast to hyphal growth and under low-iron conditions. The promoter contains E-box consensus sequences (CANNTG) suggesting that PIR1 is directly regulated by EFG1. Expression is also regulated by ACE2, HOG1, and RIM101.
messages: Highly O-glycosylated by PMT1 and contains one N-mannosylated chain.
messages: Increases sensitivity to calcofluor white and Congo red.
messages: The PIR1/2/3 repeats are required for covalent linkage to the cell wall.
messages: cell wall

237561:CAALFM CR01360WA
gene id: 237561:CAALFM_CR01360WA
uniprot id: Q5A9E6
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

237561:CAALFM C405840WA
gene id: 237561:CAALFM_C405840WA
uniprot id: A0A1D8PMF4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR02290WA
gene id: 237561:CAALFM_CR02290WA
uniprot id: Q59V02
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Putative adhesin which may be involved in cell adhesion and virulence.
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C504440CA
gene id: 237561:CAALFM_C504440CA
uniprot id: A0A1D8PNY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C405860WA
gene id: 237561:CAALFM_C405860WA
uniprot id: Q5A435
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

237561:CAALFM C701020CA
gene id: 237561:CAALFM_C701020CA
uniprot id: A0A1D8PQR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

237561:CAALFM C109160WA
gene id: 237561:CAALFM_C109160WA
uniprot id: A0A1D8PEM4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.

237561:CAALFM C305430WA
gene id: 237561:CAALFM_C305430WA
uniprot id: A0A1D8PK78
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C406500WA
gene id: 237561:CAALFM_C406500WA
uniprot id: Q5A1D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: Nucleus

237561:CAALFM C604080WA
gene id: 237561:CAALFM_C604080WA
uniprot id: Q59LF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

237561:CAALFM C205780CA
gene id: 237561:CAALFM_C205780CA
uniprot id: A0A1D8PHG7
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C206690CA
gene id: 237561:CAALFM_C206690CA
uniprot id: Q59KM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-22 family.
messages: Involved in peroxisome biogenesis.
messages: Membrane
messages: Peroxisome membrane

237561:CAALFM C109590CA
gene id: 237561:CAALFM_C109590CA
uniprot id: Q9P4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C208280WA
gene id: 237561:CAALFM_C208280WA
uniprot id: Q59K07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRG family.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

237561:CAALFM C307810CA
gene id: 237561:CAALFM_C307810CA
uniprot id: Q9P8E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

237561:CAALFM C205750WA
gene id: 237561:CAALFM_C205750WA
uniprot id: A0A1D8PHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM C101150CA
gene id: 237561:CAALFM_C101150CA
uniprot id: Q5A931
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).

237561:CAALFM C205280CA
gene id: 237561:CAALFM_C205280CA
uniprot id: A0A1D8PHD4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C306820CA
gene id: 237561:CAALFM_C306820CA
uniprot id: Q5ADM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

237561:CAALFM C303470WA
gene id: 237561:CAALFM_C303470WA
uniprot id: Q5AEC3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C600500CA
gene id: 237561:CAALFM_C600500CA
uniprot id: A0A1D8PPC6
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

237561:CAALFM CR02870WA
gene id: 237561:CAALFM_CR02870WA
uniprot id: A0A1D8PSB0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

237561:CAALFM C503160WA
gene id: 237561:CAALFM_C503160WA
uniprot id: Q5AG31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C107520CA
gene id: 237561:CAALFM_C107520CA
uniprot id: A0A1D8PE41
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C406570CA
gene id: 237561:CAALFM_C406570CA
uniprot id: P83779
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Homotetramer.

237561:CAALFM C405820WA
gene id: 237561:CAALFM_C405820WA
uniprot id: A0A1D8PMF5
names: Similarity
messages: Belongs to the complex I LYR family.

237561:CAALFM C700170WA
gene id: 237561:CAALFM_C700170WA
uniprot id: A0A1D8PQI1
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

237561:CAALFM C703110WA
gene id: 237561:CAALFM_C703110WA
uniprot id: Q5A5K7
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Predicted to be a cleavage substrate for KEX2.
messages: Putative adhesin which is involved in cell adhesion and virulence (By similarity). Plays a role in Candida-bacterial interactions and subsequent regulation of filamentation.
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C402510WA
gene id: 237561:CAALFM_C402510WA
uniprot id: A0A1D8PLJ9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C108270CA
gene id: 237561:CAALFM_C108270CA
uniprot id: A0A1D8PEC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 15 family.
messages: Nucleus

237561:CAALFM CR05950CA
gene id: 237561:CAALFM_CR05950CA
uniprot id: A0A1D8PT53
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C107360WA
gene id: 237561:CAALFM_C107360WA
uniprot id: Q59WD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts with microtubules.
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: spindle

237561:CAALFM C103260WA
gene id: 237561:CAALFM_C103260WA
uniprot id: A0A1D8PCY7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

237561:CAALFM C502190CA
gene id: 237561:CAALFM_C502190CA
uniprot id: A0A1D8PND4
names: Subcellular Location Annotation
messages: Mitochondrion

237561:CAALFM C305010CA
gene id: 237561:CAALFM_C305010CA
uniprot id: Q5AND3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

237561:CAALFM C307230WA
gene id: 237561:CAALFM_C307230WA
uniprot id: Q5ADR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

237561:CAALFM C500490CA
gene id: 237561:CAALFM_C500490CA
uniprot id: Q5A506
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell septum
messages: Cell tip
messages: Expression is increased in low iron conditions.
messages: GTPase activating protein (GAP) for RSR1 which is involved in the polarization of yeast and hyphal cells. Directs the site of new daughter cell growth in yeast and hyphal cells. Important for hyphae to maintain linear growth and necessary for hyphal responses to directional cues in the environment (tropisms). Required for correct localization of the septin rings and stabilization of the polarisome at hyphal tips. Involved in cell adhesion.
messages: cell cortex

237561:CAALFM C504000WA
gene id: 237561:CAALFM_C504000WA
uniprot id: A0A1D8PNV1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

237561:CAALFM C700150WA
gene id: 237561:CAALFM_C700150WA
uniprot id: A0A1D8PQI4
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

237561:CAALFM C202450CA
gene id: 237561:CAALFM_C202450CA
uniprot id: A0A1D8PGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

237561:CAALFM C202400WA
gene id: 237561:CAALFM_C202400WA
uniprot id: A0A1D8PGN3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C307860CA
gene id: 237561:CAALFM_C307860CA
uniprot id: Q59MJ1
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Leads to increased drug susceptibility. Displays decreased colonization of mouse kidneys. Shows decreased yeast cell adherence to silicone substrate.
messages: Membrane
messages: Nucleus
messages: Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence.

237561:CAALFM C701790CA
gene id: 237561:CAALFM_C701790CA
uniprot id: Q5AGZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR02110WA
gene id: 237561:CAALFM_CR02110WA
uniprot id: A0A1D8PS48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

237561:CAALFM C503060CA
gene id: 237561:CAALFM_C503060CA
uniprot id: A0A1D8PNL8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C702840CA
gene id: 237561:CAALFM_C702840CA
uniprot id: G1UB11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: C-22 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (Probable). ERG5 converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduc…
messages: Endoplasmic reticulum membrane

237561:CAALFM C303810WA
gene id: 237561:CAALFM_C303810WA
uniprot id: A0A1D8PJZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
messages: Nucleus

237561:CAALFM C100950CA
gene id: 237561:CAALFM_C100950CA
uniprot id: Q5ABG0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

237561:CAALFM C306490WA
gene id: 237561:CAALFM_C306490WA
uniprot id: A0A1D8PKI3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

237561:CAALFM CR08100CA
gene id: 237561:CAALFM_CR08100CA
uniprot id: Q5A396
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

237561:CAALFM C203530WA
gene id: 237561:CAALFM_C203530WA
uniprot id: A0A1D8PGY5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C505350WA
gene id: 237561:CAALFM_C505350WA
uniprot id: A0A1D8PP73
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

237561:CAALFM C502750CA
gene id: 237561:CAALFM_C502750CA
uniprot id: Q5AGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

237561:CAALFM CR07100WA
gene id: 237561:CAALFM_CR07100WA
uniprot id: A0A1D8PTE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

237561:CAALFM C601400WA
gene id: 237561:CAALFM_C601400WA
uniprot id: Q5A4J7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C207610CA
gene id: 237561:CAALFM_C207610CA
uniprot id: A0A1D8PHX5
names: Similarity
messages: Belongs to the TCF25 family.

237561:CAALFM C404180CA
gene id: 237561:CAALFM_C404180CA
uniprot id: A0A1D8PM16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
messages: Membrane

237561:CAALFM C501450WA
gene id: 237561:CAALFM_C501450WA
uniprot id: A0A1D8PN69
names: Similarity
messages: Belongs to the peptidase S10 family.

237561:CAALFM C210200WA
gene id: 237561:CAALFM_C210200WA
uniprot id: A0A1D8PIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

237561:CAALFM CR04560CA
gene id: 237561:CAALFM_CR04560CA
uniprot id: Q5A6K8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of RAD27 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM C202730WA
gene id: 237561:CAALFM_C202730WA
uniprot id: Q5A0H8
names: Similarity
messages: Belongs to the UFD1 family.

237561:CAALFM CR08680CA
gene id: 237561:CAALFM_CR08680CA
uniprot id: Q5A319
names: Function
names: Similarity
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).

237561:CAALFM C702150CA
gene id: 237561:CAALFM_C702150CA
uniprot id: Q5AH38
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

237561:CAALFM C103290WA
gene id: 237561:CAALFM_C103290WA
uniprot id: Q5AI28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

237561:CAALFM C301860CA
gene id: 237561:CAALFM_C301860CA
uniprot id: Q5AJD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
messages: Associates with the nuclear pore complex.
messages: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
messages: Cytoplasm
messages: Nucleus membrane
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nuclear pore complex

237561:CAALFM C304260WA
gene id: 237561:CAALFM_C304260WA
uniprot id: A0A1D8PJV5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C202320CA
gene id: 237561:CAALFM_C202320CA
uniprot id: Q5ALM6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C302370CA
gene id: 237561:CAALFM_C302370CA
uniprot id: A0A1D8PJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

237561:CAALFM C701270CA
gene id: 237561:CAALFM_C701270CA
uniprot id: Q59S45
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

237561:CAALFM C102960CA
gene id: 237561:CAALFM_C102960CA
uniprot id: Q5AI66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Mitochondrion inner membrane

237561:CAALFM C701800CA
gene id: 237561:CAALFM_C701800CA
uniprot id: Q5AGZ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM CR02790CA
gene id: 237561:CAALFM_CR02790CA
uniprot id: A0A1D8PSA5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

237561:CAALFM C207590WA
gene id: 237561:CAALFM_C207590WA
uniprot id: Q59U85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

237561:CAALFM C204960CA
gene id: 237561:CAALFM_C204960CA
uniprot id: A0A1D8PHE6
names: Similarity
messages: Belongs to the UPF0538 family.

237561:CAALFM CR01390WA
gene id: 237561:CAALFM_CR01390WA
uniprot id: Q5A9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

237561:CAALFM C403470CA
gene id: 237561:CAALFM_C403470CA
uniprot id: Q07730
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Acts as a cytolytic peptide toxin that directly damages host epithelial membranes, triggers a danger response signaling pathway and activates epithelial immunity (PubMed:27027296, PubMed:35073742). Probably acts similarly to cationic antimicrobial peptide toxins, inducing lesions after binding to target cell membranes and causing an inward current associated with calcium influx (PubMed:27027296).
messages: Cleavage by KEX2 generates 8 peptides ECE1-I to ECE1-VIII, all terminating in Lys-Arg (PubMed:18625069, PubMed:27027296). Only peptide ECE1-III, called candidalysin, shows toxin activity (PubMed:27027296).
messages: Expressed in elongating hyphae but not in budding yeast cells (PubMed:8359888).
messages: Expression is induced by human serum and epithelial cells (PubMed:24673895). Expression is regulated by the transcription factor EFG1 (PubMed:10464197, PubMed:10790384). Expression is also regulated by the transcription factor BCR1 (PubMed:16839200).
messages: Host cell membrane
messages: Impairs damaging of epithelia and induction of p-MKP1/c-Fos-mediated danger responses and cytokine secretion (PubMed:27027296).
messages: Secreted
messages: Secreted protein cleaved by KEX2 in 8 similar peptides (ECE1-I to ECE1-VIII) (PubMed:27027296). Stimulates biofilm formation (PubMed:16839200).
messages: The N-terminal alpha-helix of peptide ECE1-III allows insertion of the toxin into host epithelial cells membranes (PubMed:27027296).

237561:CAALFM C305050WA
gene id: 237561:CAALFM_C305050WA
uniprot id: Q5ANC8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate.
messages: Expression is induced in biofilm and repressed by fluconazole. Expression is also regulated by SS1.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate.

237561:CAALFM C407030WA
gene id: 237561:CAALFM_C407030WA
uniprot id: Q5A0Z0
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.

237561:CAALFM C702460CA
gene id: 237561:CAALFM_C702460CA
uniprot id: A0A1D8PR52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

237561:CAALFM C602440CA
gene id: 237561:CAALFM_C602440CA
uniprot id: Q5AC37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM CR03220CA
gene id: 237561:CAALFM_CR03220CA
uniprot id: Q59UG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
messages: Cytoplasm
messages: Nucleus
messages: Preautophagosomal structure

237561:CAALFM C114090WA
gene id: 237561:CAALFM_C114090WA
uniprot id: A0A1D8PFU8
names: Similarity
messages: Belongs to the GroES chaperonin family.

237561:CAALFM CR09330CA
gene id: 237561:CAALFM_CR09330CA
uniprot id: A0A1D8PTZ1
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C104450CA
gene id: 237561:CAALFM_C104450CA
uniprot id: A0A1D8PDA4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM CR03130WA
gene id: 237561:CAALFM_CR03130WA
uniprot id: A0A1D8PSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

237561:CAALFM C200350WA
gene id: 237561:CAALFM_C200350WA
uniprot id: Q5ACX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Cytoplasm
messages: Nucleus
messages: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).

237561:CAALFM C102570CA
gene id: 237561:CAALFM_C102570CA
uniprot id: Q5AIA8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C111590WA
gene id: 237561:CAALFM_C111590WA
uniprot id: A0A1D8PF62
names: Similarity
messages: Belongs to the phospholipase D family.

237561:CAALFM C204820WA
gene id: 237561:CAALFM_C204820WA
uniprot id: A0A1D8PHA0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

237561:CAALFM CR10370WA
gene id: 237561:CAALFM_CR10370WA
uniprot id: Q5ACM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

237561:CAALFM C109330WA
gene id: 237561:CAALFM_C109330WA
uniprot id: Q5APH1
names: Similarity
messages: Belongs to the TMA16 family.

237561:CAALFM CR04440CA
gene id: 237561:CAALFM_CR04440CA
uniprot id: Q5A6M0
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Expressed under acidic conditions. Expression is positively regulated by HAP43 and NRG1, and repressed by RIM101. Expression is also controlled by SUR7.
messages: Membrane
messages: Probable cell wall protein required for filamentation at low pH.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C109190CA
gene id: 237561:CAALFM_C109190CA
uniprot id: A0A1D8PEI2
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

237561:CAALFM C600820WA
gene id: 237561:CAALFM_C600820WA
uniprot id: Q59NP5
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUN family.
messages: Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction. Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides.
messages: Leads to increased cell size, cytokinesis defects, altered sensitivity to the cell wall-modifying substance Congo red, defects in adhesion, and reduced biofilm formation.
messages: Predicted to be a substrate for cleavage by KEX2.
messages: Secreted
messages: Strongly up-regulated under hypoxic conditions and in white but not opaque cells (PubMed:16854431, PubMed:19798425). Repressed by exposure to caspofungin (PubMed:15917516). Expression is probably regulated by EFG1 since SUN41 has 9 E-boxes in its promoter (PubMed:12492856).
messages: cell wall

237561:CAALFM C101580WA
gene id: 237561:CAALFM_C101580WA
uniprot id: Q5A8Y6
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

237561:CAALFM C304530CA
gene id: 237561:CAALFM_C304530CA
uniprot id: Q5ANJ4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Expression is induced by CPH2 which directly binds to the two sterol regulatory element 1-like elements upstream of TEC1. Expression is also regulated by the histone deacetylase complex HDAC3, as well as by TOR1 and EFG1. Moreover, heat shock factor-type transcriptional regulator SFL1 represses expression whereas SFL2 induces expression. In white cells, is up-regulated in the presence of alpha-pheromone. Expression is induced during oropharyngeal candidiasis (OPC). Competitors Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhimurium secreted factors decrease TEC1 expression to impair biofilm formation. Expression is also down-regulated by linoleic acid and tetrandrine.
messages: Impairs the formation of germ tubes and true hyphae; and decreases virulence in a mouse model of systemic candidiasis. Leads to defective biofilm under normoxic conditions but not under hypoxic conditions.
messages: Nucleus
messages: Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tube which is important for hyphae formation. Regulates also the pheromone response of the white cell phenotype.

237561:CAALFM C300580WA
gene id: 237561:CAALFM_C300580WA
uniprot id: A0A1D8PIY8
names: Subcellular Location Annotation
messages: cell wall

237561:CAALFM C303800WA
gene id: 237561:CAALFM_C303800WA
uniprot id: Q59ST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

237561:CAALFM C105020CA
gene id: 237561:CAALFM_C105020CA
uniprot id: Q59MB6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.
messages: Up-regulated in cells treated with farnesol and grown at high cell density in N-acetyl-D-glucosamine medium. Expression is regulated by the general amino acid control response transcription factor GCN4.

237561:CAALFM C305070WA
gene id: 237561:CAALFM_C305070WA
uniprot id: Q5ANC6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

237561:CAALFM C602220WA
gene id: 237561:CAALFM_C602220WA
uniprot id: Q59S78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).

237561:CAALFM CR05780WA
gene id: 237561:CAALFM_CR05780WA
uniprot id: Q59PT0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). Plays an important role in resistance to several stresses, as well as in autophagy and virulence (PubMed:25038082).
messages: Results in the inability to grow at alcaline pH and altered resistance to calcium, osmotic stress, cold temperature, antifungal drugs and growth on non-fermentable carbon sources. Leads also to unability to fully assemble the V-ATPase at the vacuolar membrane and impairs its proton transport and ATPase activities. Finally, leads to autophagy defect and avirulence in a Caenorhabditis elegans infection model.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

237561:CAALFM C301360CA
gene id: 237561:CAALFM_C301360CA
uniprot id: Q5AJ77
names: Disruption Phenotype
names: Function
names: Induction
messages: Decreases virulence.
messages: Expression is increased with increased iron.
messages: Transcription factor involved in iron utilization and virulence.

237561:CAALFM C108110WA
gene id: 237561:CAALFM_C108110WA
uniprot id: A0A1D8PEA9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C204220CA
gene id: 237561:CAALFM_C204220CA
uniprot id: A0A1D8PH31
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C105140WA
gene id: 237561:CAALFM_C105140WA
uniprot id: Q59LY1
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Attenuates virulence in a mouse model of systemic infection.
messages: Interacts with HDA1.
messages: Nucleus
messages: Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency.
messages: Up-regulation during the yeast-to-hypha transition is dependent upon the function of YAK1. HOG1 represses the expression of BRG1 via the transcriptional repressor SKO1. Regulated by TYE7 during late-stage biofilm formation.

237561:CAALFM C500260WA
gene id: 237561:CAALFM_C500260WA
uniprot id: Q5A4X7
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

237561:CAALFM C402080WA
gene id: 237561:CAALFM_C402080WA
uniprot id: Q5AMR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM CR07150WA
gene id: 237561:CAALFM_CR07150WA
uniprot id: Q59TZ8
names: Similarity
messages: Belongs to the hexokinase family.

237561:CAALFM C401100CA
gene id: 237561:CAALFM_C401100CA
uniprot id: Q5AMG7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C107810CA
gene id: 237561:CAALFM_C107810CA
uniprot id: Q5A7B0
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C203980CA
gene id: 237561:CAALFM_C203980CA
uniprot id: Q5AHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

237561:CAALFM C404890CA
gene id: 237561:CAALFM_C404890CA
uniprot id: Q5A6A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C200320WA
gene id: 237561:CAALFM_C200320WA
uniprot id: Q5ACW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

237561:CAALFM C205070WA
gene id: 237561:CAALFM_C205070WA
uniprot id: Q59ZI1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504910WA
gene id: 237561:CAALFM_C504910WA
uniprot id: Q5AK42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1 family.
messages: Involved in rRNA processing.
messages: nucleolus

237561:CAALFM C304290CA
gene id: 237561:CAALFM_C304290CA
uniprot id: A0A1D8PJZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

237561:CAALFM C504830WA
gene id: 237561:CAALFM_C504830WA
uniprot id: Q5AK51
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Fails to undergo filamentation under a range of hypha-inducing conditions and attenuates the virulence towards reconstituted human oral epithelium and in a mouse model of gastrointestinal colonization and dissemination.
messages: Induced at high temperature and during human oral epithelium infection.
messages: Nucleus
messages: Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1.

237561:CAALFM C602720CA
gene id: 237561:CAALFM_C602720CA
uniprot id: A0A1D8PPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

237561:CAALFM C114440CA
gene id: 237561:CAALFM_C114440CA
uniprot id: A0A1D8PFX8
names: Similarity
messages: Belongs to the Rab GDI family.

237561:CAALFM C603130WA
gene id: 237561:CAALFM_C603130WA
uniprot id: A0A1D8PQ38
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

237561:CAALFM C100640CA
gene id: 237561:CAALFM_C100640CA
uniprot id: A0A1D8PCA4
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C105110CA
gene id: 237561:CAALFM_C105110CA
uniprot id: P79023
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Inhibited by tyrosine.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

237561:CAALFM CR07260CA
gene id: 237561:CAALFM_CR07260CA
uniprot id: Q59RP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

237561:CAALFM C401950WA
gene id: 237561:CAALFM_C401950WA
uniprot id: Q5AMP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

237561:CAALFM C110620WA
gene id: 237561:CAALFM_C110620WA
uniprot id: O43101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: nucleolus

237561:CAALFM CR10180WA
gene id: 237561:CAALFM_CR10180WA
uniprot id: A0A1D8PU60
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

237561:CAALFM CR06230WA
gene id: 237561:CAALFM_CR06230WA
uniprot id: A0A1D8PT85
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR08370WA
gene id: 237561:CAALFM_CR08370WA
uniprot id: Q5A359
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

237561:CAALFM CR04580WA
gene id: 237561:CAALFM_CR04580WA
uniprot id: Q5A6K5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

237561:CAALFM C703660CA
gene id: 237561:CAALFM_C703660CA
uniprot id: Q59R20
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C703800WA
gene id: 237561:CAALFM_C703800WA
uniprot id: A0A1D8PRG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

237561:CAALFM C112200WA
gene id: 237561:CAALFM_C112200WA
uniprot id: Q5A3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).

237561:CAALFM CR09010CA
gene id: 237561:CAALFM_CR09010CA
uniprot id: A0A1D8PTV7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

237561:CAALFM C702790CA
gene id: 237561:CAALFM_C702790CA
uniprot id: A0A1D8PR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

237561:CAALFM C112290CA
gene id: 237561:CAALFM_C112290CA
uniprot id: A0A1D8PFE0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201170CA
gene id: 237561:CAALFM_C201170CA
uniprot id: A0A1D8PGA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

237561:CAALFM CR07720CA
gene id: 237561:CAALFM_CR07720CA
uniprot id: A0A1D8PTJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

237561:CAALFM C207320WA
gene id: 237561:CAALFM_C207320WA
uniprot id: Q59Z11
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM C112550CA
gene id: 237561:CAALFM_C112550CA
uniprot id: A0A1D8PFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

237561:CAALFM CR06090WA
gene id: 237561:CAALFM_CR06090WA
uniprot id: Q59V90
names: Similarity
messages: Belongs to the WD repeat LST8 family.

237561:CAALFM C304890WA
gene id: 237561:CAALFM_C304890WA
uniprot id: P78595
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane
messages: Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors.

237561:CAALFM CR08870WA
gene id: 237561:CAALFM_CR08870WA
uniprot id: A0A1D8PTW0
names: Similarity
messages: Belongs to the peroxin-13 family.

237561:CAALFM C111640CA
gene id: 237561:CAALFM_C111640CA
uniprot id: Q59TT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

237561:CAALFM C305440CA
gene id: 237561:CAALFM_C305440CA
uniprot id: Q59YU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM23 family.
messages: Mitochondrion

237561:CAALFM C204310WA
gene id: 237561:CAALFM_C204310WA
uniprot id: A0A1D8PH52
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase HMG1 finally reduces HMG-CoA to produce mevalonate (Probable).
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Expression is up-regulated in azole resistant clinical isolates (PubMed:15215138). Expression is induced by exposure to arole antifungals such as fluconazole, ketoconazole or itraconazole (PubMed:11353609, PubMed:15820985).
messages: Homotetramer.
messages: cytosol

237561:CAALFM C306970WA
gene id: 237561:CAALFM_C306970WA
uniprot id: Q5ADN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

237561:CAALFM C112340CA
gene id: 237561:CAALFM_C112340CA
uniprot id: O94150
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU).
messages: Mitochondrion

237561:CAALFM C306080WA
gene id: 237561:CAALFM_C306080WA
uniprot id: A0A1D8PKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

237561:CAALFM C201070WA
gene id: 237561:CAALFM_C201070WA
uniprot id: Q5AD50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

237561:CAALFM C207490WA
gene id: 237561:CAALFM_C207490WA
uniprot id: Q59U72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

237561:CAALFM C206470WA
gene id: 237561:CAALFM_C206470WA
uniprot id: Q59Q40
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

237561:CAALFM C101750WA
gene id: 237561:CAALFM_C101750WA
uniprot id: A0A1D8PCJ5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109060CA
gene id: 237561:CAALFM_C109060CA
uniprot id: Q5APK1
names: Similarity
messages: Belongs to the FUN14 family.

237561:CAALFM C203500WA
gene id: 237561:CAALFM_C203500WA
uniprot id: A0A1D8PGY3
names: Similarity
messages: Belongs to the LST4 family.

237561:CAALFM C105270CA
gene id: 237561:CAALFM_C105270CA
uniprot id: Q5A2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU).
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mL67/MHR1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells. mL67/MHR1 also acts as transcription factor involved in regulation of RNA polymerase II-dependent transcription.
messages: Mitochondrion
messages: Nucleus

237561:CAALFM CR01990CA
gene id: 237561:CAALFM_CR01990CA
uniprot id: A0A1D8PS42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

237561:CAALFM C306600CA
gene id: 237561:CAALFM_C306600CA
uniprot id: Q5A2W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
messages: Mitochondrion

237561:CAALFM C500700CA
gene id: 237561:CAALFM_C500700CA
uniprot id: A0A1D8PMZ8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

237561:CAALFM C107280CA
gene id: 237561:CAALFM_C107280CA
uniprot id: P0C0X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

237561:CAALFM C103530WA
gene id: 237561:CAALFM_C103530WA
uniprot id: Q5AHZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C307890WA
gene id: 237561:CAALFM_C307890WA
uniprot id: Q59MI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

237561:CAALFM CR01720WA
gene id: 237561:CAALFM_CR01720WA
uniprot id: A0A1D8PS24
names: Similarity
messages: Belongs to the sorting nexin family.

237561:CAALFM C306700CA
gene id: 237561:CAALFM_C306700CA
uniprot id: Q5A2V2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMD9 family.
messages: Binds the 3'-UTR of mitochondrial mRNAs (By similarity). Involved in the processing or stability of mitochondrial mRNAs (By similarity).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Phosphorylated. Phosphorylation promotes binding to RNA.

237561:CAALFM C111160CA
gene id: 237561:CAALFM_C111160CA
uniprot id: Q59WK2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm

237561:CAALFM C402800WA
gene id: 237561:CAALFM_C402800WA
uniprot id: A0A1D8PLP0
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C302350WA
gene id: 237561:CAALFM_C302350WA
uniprot id: A0A1D8PJF3
names: Similarity
messages: Belongs to the KRI1 family.

237561:CAALFM C111060CA
gene id: 237561:CAALFM_C111060CA
uniprot id: A0A1D8PF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR01270CA
gene id: 237561:CAALFM_CR01270CA
uniprot id: A0A1D8PRX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

237561:CAALFM C201350CA
gene id: 237561:CAALFM_C201350CA
uniprot id: Q5AD77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
messages: cytosol

237561:CAALFM C406600WA
gene id: 237561:CAALFM_C406600WA
uniprot id: A0A1D8PMM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

237561:CAALFM C302170CA
gene id: 237561:CAALFM_C302170CA
uniprot id: A0A1D8PJE0
names: Similarity
messages: Belongs to the peptidase M18 family.

237561:CAALFM CR03810WA
gene id: 237561:CAALFM_CR03810WA
uniprot id: Q5A061
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity).

237561:CAALFM C400110CA
gene id: 237561:CAALFM_C400110CA
uniprot id: A0A1D8PKY2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C202070WA
gene id: 237561:CAALFM_C202070WA
uniprot id: A0A1D8PGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

237561:CAALFM C307010WA
gene id: 237561:CAALFM_C307010WA
uniprot id: Q5ADP1
names: Similarity
messages: Belongs to the NAD kinase family.

237561:CAALFM C104520CA
gene id: 237561:CAALFM_C104520CA
uniprot id: A0A1D8PDA6
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C202970CA
gene id: 237561:CAALFM_C202970CA
uniprot id: A0A1D8PGT5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C703520WA
gene id: 237561:CAALFM_C703520WA
uniprot id: A0A1D8PRE2
names: Similarity
messages: Belongs to the isochorismatase family.

237561:CAALFM C109680WA
gene id: 237561:CAALFM_C109680WA
uniprot id: Q5APD4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFA/CMAS family.
messages: Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. Not necessary for vegetative growth at low temperatures, but plays a role in hyphal formation on solid medium.
messages: Membrane
messages: Produces only non-methylated glucosylceramides. Has a decreased hyphal growth rate.

237561:CAALFM CR02150WA
gene id: 237561:CAALFM_CR02150WA
uniprot id: Q5A951
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C105430WA
gene id: 237561:CAALFM_C105430WA
uniprot id: Q5A2B9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT20 family.
messages: Component of the SAGA complex.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). SPT20 plays a role in nuclear division and regulates hyphal and biofilm formation, which are crucial steps for virulence.
messages: Expression is down-regulated by flucytosine and upon adherence to polystyrene.
messages: Impairs proper nucleus dividing and distribution to the dividing cells. Leads to hypersensitivity to amphotericin B, fluconazole and caspofunginreduced; and to reduced virulence in the C.elegans and the G.mellonella infection models.
messages: Nucleus

237561:CAALFM C406080WA
gene id: 237561:CAALFM_C406080WA
uniprot id: A0A1D8PMH7
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).

237561:CAALFM C403740WA
gene id: 237561:CAALFM_C403740WA
uniprot id: Q59TN2
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C300460WA
gene id: 237561:CAALFM_C300460WA
uniprot id: Q5A7P7
names: Similarity
messages: Belongs to the ATPase delta chain family.

237561:CAALFM C103020CA
gene id: 237561:CAALFM_C103020CA
uniprot id: O59931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C114420WA
gene id: 237561:CAALFM_C114420WA
uniprot id: A0A1D8PFX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDI1 family.
messages: Binds ubiquitin and polyubiquitinated proteins.
messages: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

237561:CAALFM C105240CA
gene id: 237561:CAALFM_C105240CA
uniprot id: Q5A2A0
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C702470CA
gene id: 237561:CAALFM_C702470CA
uniprot id: A0A1D8PR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

237561:CAALFM C600160WA
gene id: 237561:CAALFM_C600160WA
uniprot id: Q59L96
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SED1 family.
messages: Cell wall protein that plays a role in adaptation and resistance to cell wall stress.
messages: Expression is induced in high iron conditions.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C202370CA
gene id: 237561:CAALFM_C202370CA
uniprot id: Q5ALM0
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

237561:CAALFM C205290CA
gene id: 237561:CAALFM_C205290CA
uniprot id: Q59ZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

237561:CAALFM C105880WA
gene id: 237561:CAALFM_C105880WA
uniprot id: Q5AA23
names: Similarity
messages: Belongs to the pirin family.

237561:CAALFM CR04290WA
gene id: 237561:CAALFM_CR04290WA
uniprot id: Q5A6N7
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

237561:CAALFM C501740CA
gene id: 237561:CAALFM_C501740CA
uniprot id: Q9UW23
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MATA1 family.
messages: Forms a heterodimer with ALPHA2.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating.
messages: Moderately repressed by HBR1 in response to hemoglobin and growth signals.
messages: Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
messages: Nucleus
messages: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

237561:CAALFM C403290WA
gene id: 237561:CAALFM_C403290WA
uniprot id: A0A1D8PLT5
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

237561:CAALFM C400560CA
gene id: 237561:CAALFM_C400560CA
uniprot id: Q59SI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

237561:CAALFM CR08940WA
gene id: 237561:CAALFM_CR08940WA
uniprot id: Q5A416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.
messages: Nucleus

237561:CAALFM C109020WA
gene id: 237561:CAALFM_C109020WA
uniprot id: A0A1D8PEH4
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

237561:CAALFM C200460WA
gene id: 237561:CAALFM_C200460WA
uniprot id: A0A1D8PG34
names: Similarity
messages: Belongs to the peptidase A1 family.

237561:CAALFM C306340WA
gene id: 237561:CAALFM_C306340WA
uniprot id: A0A1D8PKG2
names: Function
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.

237561:CAALFM C300620CA
gene id: 237561:CAALFM_C300620CA
uniprot id: A0A1D8PIZ2
names: Similarity
messages: Belongs to the PET191 family.

237561:CAALFM C500780CA
gene id: 237561:CAALFM_C500780CA
uniprot id: A0A1D8PN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

237561:CAALFM C102070WA
gene id: 237561:CAALFM_C102070WA
uniprot id: Q59VZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

237561:CAALFM C307830WA
gene id: 237561:CAALFM_C307830WA
uniprot id: A0A1D8PKW2
names: Similarity
messages: Belongs to the FBPase class 1 family.

237561:CAALFM C502890WA
gene id: 237561:CAALFM_C502890WA
uniprot id: Q5AG68
names: Similarity
messages: Belongs to the NDK family.

237561:CAALFM C307800CA
gene id: 237561:CAALFM_C307800CA
uniprot id: A0A1D8PL04
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C700820WA
gene id: 237561:CAALFM_C700820WA
uniprot id: A0A1D8PQP2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

237561:CAALFM C103680WA
gene id: 237561:CAALFM_C103680WA
uniprot id: Q5AIR7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 81 family.
messages: Cleaves internal linkages in 1,3-beta-glucan (PubMed:16328626). Involved in the cell separation process. Plays no essential role in growth, nor is it involved in hyphal morphogenesis (PubMed:16328626).
messages: Expression is decreased during the hyphal transition, in biofilm, as well as by heat stress, caspofungin, fluconazole, and alpha pheromone. Transcription is also regulated by ACE2 and SIT4.
messages: Leads to clusters of growing cells that have not completed separation.
messages: cell wall

237561:CAALFM C505370CA
gene id: 237561:CAALFM_C505370CA
uniprot id: A0A1D8PP74
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C208640CA
gene id: 237561:CAALFM_C208640CA
uniprot id: Q59Y37
names: Similarity
messages: Belongs to the WrbA family.

237561:CAALFM C603500CA
gene id: 237561:CAALFM_C603500CA
uniprot id: Q5A8N2
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activity is inhibited by squash aspartic peptidase inhibitor (SQAPI).
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae and true hyphae. Induced during host infection. Expression is suppressed by fluconazole.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C400020WA
gene id: 237561:CAALFM_C400020WA
uniprot id: A0A1D8PKX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

237561:CAALFM C103940WA
gene id: 237561:CAALFM_C103940WA
uniprot id: A0A1D8PD61
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C108380WA
gene id: 237561:CAALFM_C108380WA
uniprot id: Q59QD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

237561:CAALFM C210460CA
gene id: 237561:CAALFM_C210460CA
uniprot id: Q5A5S8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

237561:CAALFM C113550CA
gene id: 237561:CAALFM_C113550CA
uniprot id: A0A1D8PFQ0
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: nuclear pore complex

237561:CAALFM C402850WA
gene id: 237561:CAALFM_C402850WA
uniprot id: A0A1D8PLN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C504750CA
gene id: 237561:CAALFM_C504750CA
uniprot id: Q5AK59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM CR05180CA
gene id: 237561:CAALFM_CR05180CA
uniprot id: Q59QN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

237561:CAALFM C110650WA
gene id: 237561:CAALFM_C110650WA
uniprot id: A0A1D8PEX6
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

237561:CAALFM C503350WA
gene id: 237561:CAALFM_C503350WA
uniprot id: P83782
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Mitochondrion inner membrane

237561:CAALFM C501380WA
gene id: 237561:CAALFM_C501380WA
uniprot id: A0A1D8PN52
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404050CA
gene id: 237561:CAALFM_C404050CA
uniprot id: Q5A5U4
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Component of the cell wall involved in virulence. Does not seem to have a major role in maintaining cell wall integrity but plays a role in the relationship between C.albicans and the host.
messages: Down-regulated during yeast-to-hyphal transition and by fluconazole. Induced during cell wall regeneration following protoplasting and highly overexpressed after treatment with micafungin.
messages: Leads to a significant reduction of cell wall mannan and to decreased virulence with a diminished induction of host pro-inflammatory cytokines.
messages: Membrane
messages: O-glycosylated by PMT1.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C701760CA
gene id: 237561:CAALFM_C701760CA
uniprot id: Q5AGZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

237561:CAALFM C101350CA
gene id: 237561:CAALFM_C101350CA
uniprot id: P87206
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C114080WA
gene id: 237561:CAALFM_C114080WA
uniprot id: Q59ZX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
messages: Membrane
messages: nucleolus

237561:CAALFM C402950CA
gene id: 237561:CAALFM_C402950CA
uniprot id: Q5AFA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C400680WA
gene id: 237561:CAALFM_C400680WA
uniprot id: A0A1D8PL42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

237561:CAALFM C210360CA
gene id: 237561:CAALFM_C210360CA
uniprot id: O94048
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethan group.

237561:CAALFM C104430CA
gene id: 237561:CAALFM_C104430CA
uniprot id: A0A1D8PDA0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C112810WA
gene id: 237561:CAALFM_C112810WA
uniprot id: A0A1D8PFH0
names: Function
names: Similarity
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

237561:CAALFM CR08010WA
gene id: 237561:CAALFM_CR08010WA
uniprot id: A0A1D8PTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD4 family.
messages: Nucleus
messages: kinetochore
messages: spindle

237561:CAALFM C110830WA
gene id: 237561:CAALFM_C110830WA
uniprot id: Q59WG7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: N-glycosylated.
messages: Present with 3460 molecules/cell in log phase SD medium.
messages: Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence.

237561:CAALFM C111620WA
gene id: 237561:CAALFM_C111620WA
uniprot id: Q59TT6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C402640CA
gene id: 237561:CAALFM_C402640CA
uniprot id: Q5AF73
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

237561:CAALFM C604370WA
gene id: 237561:CAALFM_C604370WA
uniprot id: A0A1D8PQF0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C403410WA
gene id: 237561:CAALFM_C403410WA
uniprot id: A0A1D8PLT6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

237561:CAALFM C112260WA
gene id: 237561:CAALFM_C112260WA
uniprot id: A0A1D8PFF4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C304200WA
gene id: 237561:CAALFM_C304200WA
uniprot id: Q5ANN8
names: Similarity
messages: Belongs to the arginase family.

237561:CAALFM C301560WA
gene id: 237561:CAALFM_C301560WA
uniprot id: Q5AJA5
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

237561:CAALFM CR01180WA
gene id: 237561:CAALFM_CR01180WA
uniprot id: Q5A893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

237561:CAALFM C406970CA
gene id: 237561:CAALFM_C406970CA
uniprot id: A0A1D8PMR6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00230WA
gene id: 237561:CAALFM_CR00230WA
uniprot id: A0A1D8PRM4
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

237561:CAALFM C107350CA
gene id: 237561:CAALFM_C107350CA
uniprot id: Q59WD3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Interacts with CAP1 and probably YBP1.
messages: Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator CAP1, which is involved in transcription activation of genes of the oxidative stress response pathway (PubMed:23706023). May also play a direct role in hydroperoxide scavenging. The enzyme is not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, GPX3 is directly oxidized at Cys-43 to form a cysteine sulfenic acid (-SOH). Cys-43-SOH then forms either an intramolecular disulfide bond (Cys-43 with Cys-89) or a transient, intermolecular disulfide bond with 'Cys-446' of CAP1, which is further resolved into a CAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-43 in GPX3 (By similarity). Required for C.albicans-mediated macrophage killing (PubMed:23706023).
messages: Sensitive to hydrogen peroxide. Unable to filament and thus, escape from murine macrophages after phagocytosis. Also displays defective virulence in the Galleria mellonella infection model.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide.

237561:CAALFM C207430CA
gene id: 237561:CAALFM_C207430CA
uniprot id: A0A1D8PI06
names: Similarity
messages: Belongs to the IUNH family.

237561:CAALFM C400520WA
gene id: 237561:CAALFM_C400520WA
uniprot id: Q59SI2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
messages: Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.

237561:CAALFM C303990CA
gene id: 237561:CAALFM_C303990CA
uniprot id: A0A1D8PJU0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR07360WA
gene id: 237561:CAALFM_CR07360WA
uniprot id: Q59RQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replication fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

237561:CAALFM C205920CA
gene id: 237561:CAALFM_C205920CA
uniprot id: A0A1D8PHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C205680WA
gene id: 237561:CAALFM_C205680WA
uniprot id: Q59T37
names: Similarity
messages: Belongs to the COG4 family.

237561:CAALFM C306020WA
gene id: 237561:CAALFM_C306020WA
uniprot id: P53697
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP1/MMN9/VAN1 family.
messages: Golgi apparatus membrane
messages: Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.

237561:CAALFM C304570CA
gene id: 237561:CAALFM_C304570CA
uniprot id: A0A1D8PJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM C401170CA
gene id: 237561:CAALFM_C401170CA
uniprot id: Q5AMH3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.
messages: Expression is regulated by SEF1, SFU1, and HAP43.
messages: Membrane

237561:CAALFM C306770WA
gene id: 237561:CAALFM_C306770WA
uniprot id: Q5ADL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C206010WA
gene id: 237561:CAALFM_C206010WA
uniprot id: Q59X11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2/SPO72 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2/SPO72 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
messages: Preautophagosomal structure membrane

237561:CAALFM C300920WA
gene id: 237561:CAALFM_C300920WA
uniprot id: A0A1D8PJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C701940CA
gene id: 237561:CAALFM_C701940CA
uniprot id: Q5AH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

237561:CAALFM C405690WA
gene id: 237561:CAALFM_C405690WA
uniprot id: Q5A455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.

237561:CAALFM CR10490WA
gene id: 237561:CAALFM_CR10490WA
uniprot id: Q9P975
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity).

237561:CAALFM C107700CA
gene id: 237561:CAALFM_C107700CA
uniprot id: Q5A477
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation.

237561:CAALFM CR06760CA
gene id: 237561:CAALFM_CR06760CA
uniprot id: A0A1D8PTB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

237561:CAALFM CR07760WA
gene id: 237561:CAALFM_CR07760WA
uniprot id: A0A1D8PTL2
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

237561:CAALFM CR03880WA
gene id: 237561:CAALFM_CR03880WA
uniprot id: Q5A6U1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Induced in low iron conditions.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C601820CA
gene id: 237561:CAALFM_C601820CA
uniprot id: A0A1D8PPQ0
names: Similarity
messages: Belongs to the FPG family.

237561:CAALFM C603760CA
gene id: 237561:CAALFM_C603760CA
uniprot id: O13426
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Has antigenic properties.
messages: Homotetramer.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.

237561:CAALFM CR06710CA
gene id: 237561:CAALFM_CR06710CA
uniprot id: Q59PZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus

237561:CAALFM CR02420WA
gene id: 237561:CAALFM_CR02420WA
uniprot id: A0A1D8PS68
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C501760CA
gene id: 237561:CAALFM_C501760CA
uniprot id: Q9UW24
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Nucleus
messages: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

237561:CAALFM C305210CA
gene id: 237561:CAALFM_C305210CA
uniprot id: A0A1D8PK53
names: Subunit
messages: Consists of at least two heavy chains and a number of intermediate and light chains.

237561:CAALFM C403320WA
gene id: 237561:CAALFM_C403320WA
uniprot id: A0A1D8PLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

237561:CAALFM C201020WA
gene id: 237561:CAALFM_C201020WA
uniprot id: Q5AD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR09790WA
gene id: 237561:CAALFM_CR09790WA
uniprot id: O93852
names: Disruption Phenotype
names: Function
names: Similarity
messages: Abolishes D-arabinono-1,4-lactone oxidase activity and impairs the production of D-erythroascorbic acid (PubMed:11349062). Leads to increased sensitivity towards oxidative stress, defective hyphal growth and attenuated virulence (PubMed:11349062).
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: D-arabinono-1,4-lactone oxidase that catalyzes the final step of biosynthesis of D-erythroascorbic acid, an important antioxidant and one of the virulence factors enhancing the pathogenicity (PubMed:11349062, PubMed:7957197). Is also able to oxidize L-galactono-1,4-lactone, L-xylono-1,4-lactone and L-gulono-1,4-lactone (PubMed:7957197).

237561:CAALFM C301630WA
gene id: 237561:CAALFM_C301630WA
uniprot id: Q5AJB1
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:25220074). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:25220074). Mediates oxidative stress response, filamentous growth, and plays an important role in virulence (PubMed:25220074).
messages: Cytoplasm
messages: Endomembrane system
messages: Is a probable target for sumoylation.
messages: Leads to a defect in vacuolar acidification and higher sensitivity to oxidants such as H(2)O(2) or menadione. Reduces strongly virulence in mice.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

237561:CAALFM C501590WA
gene id: 237561:CAALFM_C501590WA
uniprot id: A0A1D8PN68
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

237561:CAALFM CR01820WA
gene id: 237561:CAALFM_CR01820WA
uniprot id: A0A1D8PS32
names: Similarity
messages: Belongs to the NEMF family.

237561:CAALFM C200280CA
gene id: 237561:CAALFM_C200280CA
uniprot id: Q5ACW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C205270WA
gene id: 237561:CAALFM_C205270WA
uniprot id: A0A1D8PHD1
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM CR03360WA
gene id: 237561:CAALFM_CR03360WA
uniprot id: Q59UH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

237561:CAALFM C601180CA
gene id: 237561:CAALFM_C601180CA
uniprot id: A0A1D8PPK1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
messages: Decreases phagocytosis of the fungus by host cells (PubMed:34986357). Increases expression of GPD2 (PubMed:34986357).
messages: Induced by estrogen (17beta-estradiol).
messages: Oxidoreductase that binds mammalian estrogens with high affinity.

237561:CAALFM C109120WA
gene id: 237561:CAALFM_C109120WA
uniprot id: A0A1D8PEJ5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C206210CA
gene id: 237561:CAALFM_C206210CA
uniprot id: Q59P52
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

237561:CAALFM C406340WA
gene id: 237561:CAALFM_C406340WA
uniprot id: A0A1D8PMK0
names: Similarity
messages: Belongs to the argonaute family.

237561:CAALFM C203120WA
gene id: 237561:CAALFM_C203120WA
uniprot id: Q5A0M7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

237561:CAALFM C300800WA
gene id: 237561:CAALFM_C300800WA
uniprot id: A0A1D8PJ05
names: Similarity
messages: Belongs to the MPI phosphatase family.

237561:CAALFM C406490CA
gene id: 237561:CAALFM_C406490CA
uniprot id: A0A1D8PML0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

237561:CAALFM C303910WA
gene id: 237561:CAALFM_C303910WA
uniprot id: Q59SU5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-5; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-129.

237561:CAALFM C505120WA
gene id: 237561:CAALFM_C505120WA
uniprot id: Q5AK16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

237561:CAALFM C202790CA
gene id: 237561:CAALFM_C202790CA
uniprot id: A0A1D8PGP7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C301480CA
gene id: 237561:CAALFM_C301480CA
uniprot id: Q5AJ92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Cytoplasm
messages: Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.

237561:CAALFM C504650CA
gene id: 237561:CAALFM_C504650CA
uniprot id: A0A1D8PP08
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C201320WA
gene id: 237561:CAALFM_C201320WA
uniprot id: A0A1D8PGA6
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

237561:CAALFM CR09340WA
gene id: 237561:CAALFM_CR09340WA
uniprot id: A0A1D8PTY7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C104980CA
gene id: 237561:CAALFM_C104980CA
uniprot id: A0A1D8PDG5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C100330CA
gene id: 237561:CAALFM_C100330CA
uniprot id: A0A1D8PC71
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

237561:CAALFM C109150WA
gene id: 237561:CAALFM_C109150WA
uniprot id: A0A1D8PEH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.

237561:CAALFM C703840WA
gene id: 237561:CAALFM_C703840WA
uniprot id: A0A1D8PRG1
names: Similarity
messages: Belongs to the CNOT9 family.

237561:CAALFM C502470WA
gene id: 237561:CAALFM_C502470WA
uniprot id: P53705
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD4 family.
messages: Bud neck
messages: Cell surface
messages: Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis.
messages: perispore

237561:CAALFM C500570WA
gene id: 237561:CAALFM_C500570WA
uniprot id: A0A1D8PMY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

237561:CAALFM CR08250CA
gene id: 237561:CAALFM_CR08250CA
uniprot id: A0A1D8PTP9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

237561:CAALFM C206620WA
gene id: 237561:CAALFM_C206620WA
uniprot id: A0A1D8PHP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

237561:CAALFM C113130CA
gene id: 237561:CAALFM_C113130CA
uniprot id: Q5AL37
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR03020CA
gene id: 237561:CAALFM_CR03020CA
uniprot id: Q5A1X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

237561:CAALFM C113480WA
gene id: 237561:CAALFM_C113480WA
uniprot id: P41797
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds human HTN3/histatin-5, a peptide from saliva, and mediates its fungicidal activity.
messages: Cytoplasm
messages: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.
messages: cell wall

237561:CAALFM C103760CA
gene id: 237561:CAALFM_C103760CA
uniprot id: A0A1D8PD47
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

237561:CAALFM CR05480WA
gene id: 237561:CAALFM_CR05480WA
uniprot id: A0A1D8PT04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C102020WA
gene id: 237561:CAALFM_C102020WA
uniprot id: Q59TA8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

237561:CAALFM C304560WA
gene id: 237561:CAALFM_C304560WA
uniprot id: Q5ANI8
names: Similarity
messages: Belongs to the CBF/MAK21 family.

237561:CAALFM C113860CA
gene id: 237561:CAALFM_C113860CA
uniprot id: A0A1D8PFS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

237561:CAALFM CR00060CA
gene id: 237561:CAALFM_CR00060CA
uniprot id: A0A1D8PRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Nucleus
messages: telomere

237561:CAALFM C701990CA
gene id: 237561:CAALFM_C701990CA
uniprot id: A0A1D8PQZ8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR02580WA
gene id: 237561:CAALFM_CR02580WA
uniprot id: A0A1D8PS97
names: Similarity
messages: Belongs to the pantothenate synthetase family.

237561:CAALFM C104410CA
gene id: 237561:CAALFM_C104410CA
uniprot id: Q59KZ2
names: Function
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C601770WA
gene id: 237561:CAALFM_C601770WA
uniprot id: Q5A4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
messages: Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.
messages: Nucleus

237561:CAALFM C600650CA
gene id: 237561:CAALFM_C600650CA
uniprot id: A0A1D8PPE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM CR07890WA
gene id: 237561:CAALFM_CR07890WA
uniprot id: Q59X67
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EFG1/PHD1/stuA family.
messages: Expression is specific for the white growth phase. Down-regulation under hyphal induction depends on the presence of EFG1 itself which plays a role of autoinhibitor and the protein kinase A isoforms TPK1 and TPK2.
messages: Interacts with CZF1 and FLO8.
messages: Nucleus
messages: Thr-208 is a phosphorylation target to promote hyphal induction by a subset of environmental cues. Phosphorylation at Thr-181 by the CDc28/HGC1 complex represses cell separation genes and leads to hyphal chain formation.
messages: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequence (EGRbox) TATGCATA. Acts as a major regulator of cell wall dynamics and plays a role in interactions with extracellular matrices. Required for TOR1-dependent cellular aggregation and adhesin expression. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. Contributes to virulence by regulating hyphal formation and the factors that enable C.albicans to invade and injure endothelial cells. Required for the formation of thick-walled big resting spores called chlamydospores, which survive in unfavorable conditions. Mediates the expression of virulence factors SAP4, SAP5and SAP6 during infection. Involved in drug resistance by regulating the expression of ERG3.

237561:CAALFM C401510WA
gene id: 237561:CAALFM_C401510WA
uniprot id: Q5AML3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C107120WA
gene id: 237561:CAALFM_C107120WA
uniprot id: Q59WB3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease involved in S-adenosylmethionine (SAM) transport and required for SAM-induced morphogenesis (PubMed:28028545). GAP4 is also able to transport arginine and thialysine, and thus probably also lysine (PubMed:21764911).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is also regulated by HAP43, GCN2, GCN4 and SSN6 (PubMed:16215176, PubMed:15814841, PubMed:21592964). Induced during biofilm development (PubMed:22265407).

237561:CAALFM CR03640CA
gene id: 237561:CAALFM_CR03640CA
uniprot id: Q5A026
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C204650CA
gene id: 237561:CAALFM_C204650CA
uniprot id: A0A1D8PH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

237561:CAALFM CR03500WA
gene id: 237561:CAALFM_CR03500WA
uniprot id: A0A1D8PSH3
names: Similarity
messages: Belongs to the citrate synthase family.

237561:CAALFM CR02220CA
gene id: 237561:CAALFM_CR02220CA
uniprot id: A0A1D8PS61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C109390WA
gene id: 237561:CAALFM_C109390WA
uniprot id: A0A1D8PEK6
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

237561:CAALFM CR02680WA
gene id: 237561:CAALFM_CR02680WA
uniprot id: Q5A216
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

237561:CAALFM C102850WA
gene id: 237561:CAALFM_C102850WA
uniprot id: Q5AI80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
messages: cytosol

237561:CAALFM CR03270WA
gene id: 237561:CAALFM_CR03270WA
uniprot id: A0A1D8PSE5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C301820WA
gene id: 237561:CAALFM_C301820WA
uniprot id: A0A1D8PJB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

237561:CAALFM CR05630WA
gene id: 237561:CAALFM_CR05630WA
uniprot id: Q59PR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C201530CA
gene id: 237561:CAALFM_C201530CA
uniprot id: Q5ALW6
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

237561:CAALFM C700230WA
gene id: 237561:CAALFM_C700230WA
uniprot id: A0A1D8PQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C209900CA
gene id: 237561:CAALFM_C209900CA
uniprot id: Q59YG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR08570WA
gene id: 237561:CAALFM_CR08570WA
uniprot id: Q5A337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Cytoplasm

237561:CAALFM C500930CA
gene id: 237561:CAALFM_C500930CA
uniprot id: Q5A1M1
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

237561:CAALFM C114220CA
gene id: 237561:CAALFM_C114220CA
uniprot id: A0A1D8PFV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

237561:CAALFM C100510WA
gene id: 237561:CAALFM_C100510WA
uniprot id: Q5ABB3
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

237561:CAALFM C207500CA
gene id: 237561:CAALFM_C207500CA
uniprot id: Q59U73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C106070WA
gene id: 237561:CAALFM_C106070WA
uniprot id: Q5AA46
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

237561:CAALFM C405640CA
gene id: 237561:CAALFM_C405640CA
uniprot id: A0A1D8PMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

237561:CAALFM C107800WA
gene id: 237561:CAALFM_C107800WA
uniprot id: Q5A7B1
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

237561:CAALFM C505320CA
gene id: 237561:CAALFM_C505320CA
uniprot id: P46586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
messages: Cytoplasm

237561:CAALFM C203290WA
gene id: 237561:CAALFM_C203290WA
uniprot id: A0A1D8PGX4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C113760WA
gene id: 237561:CAALFM_C113760WA
uniprot id: Q5AKW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

237561:CAALFM C106230CA
gene id: 237561:CAALFM_C106230CA
uniprot id: Q59MC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

237561:CAALFM C108750WA
gene id: 237561:CAALFM_C108750WA
uniprot id: A0A1D8PED5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C505460CA
gene id: 237561:CAALFM_C505460CA
uniprot id: Q5AJX5
names: Similarity
messages: Belongs to the DeSI family.

237561:CAALFM C105300CA
gene id: 237561:CAALFM_C105300CA
uniprot id: Q5A2A7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

237561:CAALFM C204030CA
gene id: 237561:CAALFM_C204030CA
uniprot id: Q5AHH7
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

237561:CAALFM C307550CA
gene id: 237561:CAALFM_C307550CA
uniprot id: Q5ADV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
messages: May be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion

237561:CAALFM C701950WA
gene id: 237561:CAALFM_C701950WA
uniprot id: Q5AH12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Golgi apparatus membrane
messages: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
messages: cis-Golgi network membrane

237561:CAALFM C401790WA
gene id: 237561:CAALFM_C401790WA
uniprot id: Q5AMN3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG11 family.
messages: Homodimer and potential homooligomers.
messages: Impairs the transport and degradation of ATG8 (PubMed:31284951). Suppresses also the degradation of both LAP41 (the indicator of the cytoplasm-to-vacuole pathway) and CSP37 (the indicator of mitophagy) (PubMed:31284951).
messages: Induced during biofilm formation.
messages: Plays an essential role in both non-selective and selective autophagy such as mitophagy (PubMed:31284951). Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity). Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity). Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity).
messages: Preautophagosomal structure membrane

237561:CAALFM C303190CA
gene id: 237561:CAALFM_C303190CA
uniprot id: Q5AEF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GcvT family. CAF17 subfamily.
messages: Mitochondrion

237561:CAALFM C604560WA
gene id: 237561:CAALFM_C604560WA
uniprot id: A0A1D8PQF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

237561:CAALFM C104900WA
gene id: 237561:CAALFM_C104900WA
uniprot id: Q59VL7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Induced during biofilm formation and Up-regulated in response to treatment with MUC7 12-mer, a cationic antimicrobial peptide derived from the N-terminal region of human low-molecular-weight salivary mucin.
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).

237561:CAALFM C402260CA
gene id: 237561:CAALFM_C402260CA
uniprot id: Q5AMT3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

237561:CAALFM C203220CA
gene id: 237561:CAALFM_C203220CA
uniprot id: Q5AH87
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Induced in biofilm, by caspofugin, as well as by 17-beta-estradiol and ethynyl estradiol. Expression is regulated by SSN6.
messages: Nucleus
messages: Probable transcription factor involved in response to cell wall damage.

237561:CAALFM C704160WA
gene id: 237561:CAALFM_C704160WA
uniprot id: A0A1D8PRJ3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C203270WA
gene id: 237561:CAALFM_C203270WA
uniprot id: P82612
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Cytoplasm
messages: Has antigenic properties.

237561:CAALFM C102920WA
gene id: 237561:CAALFM_C102920WA
uniprot id: A0A1D8PCW7
names: Similarity
messages: Belongs to the CDC73 family.

237561:CAALFM C301710CA
gene id: 237561:CAALFM_C301710CA
uniprot id: A0A1D8PJ89
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

237561:CAALFM C200840WA
gene id: 237561:CAALFM_C200840WA
uniprot id: Q5AD27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.

237561:CAALFM C100070WA
gene id: 237561:CAALFM_C100070WA
uniprot id: A0A1D8PC43
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:12073030). MVD1 converts diphosphomevalonate into isopentenyl diphosphate (PubMed:12073030). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
messages: Expression is high in media supplemented with glucose, moderate in acetate, galactose and low in maltose medium (PubMed:12073030). Expression is higher in the yeast phase than in the hyphal phase of growth as well as higher in the exponential than in the stationary phase (PubMed:12073030). Expression is affected by antifungals (PubMed:15917516). Expression is repressed during biofilm formation (PubMed:19527170, PubMed:22265407).
messages: Homodimer.

237561:CAALFM C504550WA
gene id: 237561:CAALFM_C504550WA
uniprot id: A0A1D8PNZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

237561:CAALFM CR09890CA
gene id: 237561:CAALFM_CR09890CA
uniprot id: A0A1D8PU24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

237561:CAALFM C112270WA
gene id: 237561:CAALFM_C112270WA
uniprot id: A0A1D8PFD1
names: Similarity
messages: Belongs to the UPP synthase family.

237561:CAALFM C102640CA
gene id: 237561:CAALFM_C102640CA
uniprot id: Q5AIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

237561:CAALFM C504080CA
gene id: 237561:CAALFM_C504080CA
uniprot id: Q59LQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C302110WA
gene id: 237561:CAALFM_C302110WA
uniprot id: Q5AJF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the large ribosomal subunit (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit (By similarity). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (By similarity). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C109210CA
gene id: 237561:CAALFM_C109210CA
uniprot id: A0A1D8PEJ7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR03780CA
gene id: 237561:CAALFM_CR03780CA
uniprot id: Q5A012
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C604600WA
gene id: 237561:CAALFM_C604600WA
uniprot id: A0A1D8PQG3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

237561:CAALFM CR06720WA
gene id: 237561:CAALFM_CR06720WA
uniprot id: Q59PZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C113300CA
gene id: 237561:CAALFM_C113300CA
uniprot id: A0A1D8PFL7
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

237561:CAALFM C303890WA
gene id: 237561:CAALFM_C303890WA
uniprot id: P43069
names: Function
messages: Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

237561:CAALFM C501440CA
gene id: 237561:CAALFM_C501440CA
uniprot id: Q59NR8
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

237561:CAALFM C402500CA
gene id: 237561:CAALFM_C402500CA
uniprot id: Q5AF56
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Affects filamentous growth.
messages: Expression is increased in biofilm.
messages: Nucleus
messages: Targets a different set of genes than S.cerevisiae ADR1.
messages: Transcription factor involved in the regulation of hyphal growth.

237561:CAALFM CR02000CA
gene id: 237561:CAALFM_CR02000CA
uniprot id: O94069
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Homodimer.
messages: Mitochondrion matrix

237561:CAALFM C207060WA
gene id: 237561:CAALFM_C207060WA
uniprot id: A0A1D8PHX6
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C208240WA
gene id: 237561:CAALFM_C208240WA
uniprot id: A0A1D8PI28
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C703050WA
gene id: 237561:CAALFM_C703050WA
uniprot id: G1UB68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C603440WA
gene id: 237561:CAALFM_C603440WA
uniprot id: Q5A8W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCM1 family.
messages: Mitochondrion
messages: RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).

237561:CAALFM C210570WA
gene id: 237561:CAALFM_C210570WA
uniprot id: Q5A5R4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

237561:CAALFM C108520CA
gene id: 237561:CAALFM_C108520CA
uniprot id: Q59QC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

237561:CAALFM C111340WA
gene id: 237561:CAALFM_C111340WA
uniprot id: Q59W55
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: By pheromones during mating.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.

237561:CAALFM C503620WA
gene id: 237561:CAALFM_C503620WA
uniprot id: A0A1D8PNS6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

237561:CAALFM C108450CA
gene id: 237561:CAALFM_C108450CA
uniprot id: P0CY33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Involved in hyphal formation, virulence, morphogenesis.

237561:CAALFM C401910WA
gene id: 237561:CAALFM_C401910WA
uniprot id: Q5AMP5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C204710CA
gene id: 237561:CAALFM_C204710CA
uniprot id: Q96WL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily.
messages: Homodimer.
messages: Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).

237561:CAALFM C108790WA
gene id: 237561:CAALFM_C108790WA
uniprot id: A0A1D8PEG8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C100780CA
gene id: 237561:CAALFM_C100780CA
uniprot id: Q5ABE2
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cyclin family.
messages: Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth. Moreover CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth. Also partially controls SEP7 phosphorylation status and subsequent septin ring dynamics. Required for virulence and especially mediates dynamic adhesion to endothelium of blood vessels during circulation.
messages: Interacts with CDC28.
messages: Transcript is detected only in the apical cells of hyphae, suggesting that HGC1 is transcribed in the apical cell. Induced during hyphal formation and upon exposure to host serum. Expression is regulated by the cAMP/PKA pathway, EFG1, FLO8, SSN6, RAD52, TUP1, and UME6. Repressed by farnesol and linalool.

237561:CAALFM C108470WA
gene id: 237561:CAALFM_C108470WA
uniprot id: Q59QC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C111010CA
gene id: 237561:CAALFM_C111010CA
uniprot id: A0A1D8PF18
names: Subcellular Location Annotation
messages: Peroxisome membrane

237561:CAALFM C703250CA
gene id: 237561:CAALFM_C703250CA
uniprot id: A0A1D8PR99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

237561:CAALFM C201360CA
gene id: 237561:CAALFM_C201360CA
uniprot id: Q5AD78
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 76 family.
messages: Cell membrane
messages: Induced by HAP43 and up-regulated in absence of CYR1.
messages: Probable mannosidase required for normal synthesis of the cell wall.

237561:CAALFM C106640CA
gene id: 237561:CAALFM_C106640CA
uniprot id: A0A1D8PDX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

237561:CAALFM C404270WA
gene id: 237561:CAALFM_C404270WA
uniprot id: Q59P95
names: Subunit
messages: Homodimer.

237561:CAALFM C111880WA
gene id: 237561:CAALFM_C111880WA
uniprot id: Q5A3J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU).
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism.
messages: Mitochondrion

237561:CAALFM C208930WA
gene id: 237561:CAALFM_C208930WA
uniprot id: Q59SD0
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

237561:CAALFM C404800WA
gene id: 237561:CAALFM_C404800WA
uniprot id: A0A1D8PM53
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C113700WA
gene id: 237561:CAALFM_C113700WA
uniprot id: A0A1D8PFR4
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

237561:CAALFM C500760WA
gene id: 237561:CAALFM_C500760WA
uniprot id: A0A1D8PN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C207650CA
gene id: 237561:CAALFM_C207650CA
uniprot id: A0A1D8PHY7
names: Similarity
messages: Belongs to the peptidase S33 family.

237561:CAALFM C303420CA
gene id: 237561:CAALFM_C303420CA
uniprot id: Q5AEC9
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

237561:CAALFM C112760WA
gene id: 237561:CAALFM_C112760WA
uniprot id: Q59PE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Cytoplasm
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

237561:CAALFM C208820CA
gene id: 237561:CAALFM_C208820CA
uniprot id: A0A1D8PID6
names: Similarity
messages: Belongs to the TOP6A family.

237561:CAALFM C303260WA
gene id: 237561:CAALFM_C303260WA
uniprot id: A0A1D8PJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

237561:CAALFM C204280WA
gene id: 237561:CAALFM_C204280WA
uniprot id: A0A1D8PH46
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

237561:CAALFM C108030WA
gene id: 237561:CAALFM_C108030WA
uniprot id: Q5A786
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

237561:CAALFM C701520WA
gene id: 237561:CAALFM_C701520WA
uniprot id: G1UB37
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
messages: Cell membrane
messages: Expression is positively regulated by the CAP1 transcription activator (PubMed:19395663). Expression is also regulated by the MRR1 transcription factor (PubMed:28953977). Expression is inhibited by tetrandrine (TET), a compound known to act in a synergistic manner with fluconazole (PubMed:19420894, PubMed:23527892). Expression is increased in clinical azole-resistant isolates (PubMed:23769565, PubMed:24962255).
messages: Increases the susceptibility to mycophenolic acid, fuconazole, ketoconazole and itraconazole (PubMed:11065353). Reduces the efflux of spermidine as well as of histatin 5, a salivary human antimicrobial peptide that is toxic to the opportunistic yeast C.albicans (PubMed:23380720). Leads also to reduced biofilm formation (PubMed:23380720).
messages: Major facilitator superfamily transporter that mediates resistance to structurally and functionally unrelated compounds including cycloheximide but also azoles such as fuconazole, ketoconazole and itraconazole (PubMed:11065353, PubMed:11181345). Mediates also efflux of histatin 5, a salivary human antimicrobial peptide, and is responsible for reduction of its toxicity in C.albicans (PubMed:23380720, PubMed:28953977).

237561:CAALFM CR02560CA
gene id: 237561:CAALFM_CR02560CA
uniprot id: Q59LV8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASG1 family.
messages: Decreased hyphal formation.
messages: Nucleus
messages: Transcription factor necessary to sustain growth on non-fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation.

237561:CAALFM C202180WA
gene id: 237561:CAALFM_C202180WA
uniprot id: A0A1D8PGH6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C402240CA
gene id: 237561:CAALFM_C402240CA
uniprot id: Q5AMT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.

237561:CAALFM CR06120WA
gene id: 237561:CAALFM_CR06120WA
uniprot id: Q59V85
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

237561:CAALFM C406000WA
gene id: 237561:CAALFM_C406000WA
uniprot id: Q59Q79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity).

237561:CAALFM C100550WA
gene id: 237561:CAALFM_C100550WA
uniprot id: A0A1D8PC84
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

237561:CAALFM C402030WA
gene id: 237561:CAALFM_C402030WA
uniprot id: Q5AMQ6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFX family.
messages: Expression is negatively regulated by NRG1, and by the contact with host oral epithelial cells. Up-regulated during the yeast-to-hypha transition through the function of YAK1. Also regulated by SWI4, SWI6, and WOR1, a transcriptional regulator of white-opaque switching.
messages: Leads to increased resistance to UV-killing, derepression of various stress-related genes, hyperfilamentous growth, and overexpression of hypha-specific genes.
messages: Nucleus
messages: Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1.

237561:CAALFM C703010WA
gene id: 237561:CAALFM_C703010WA
uniprot id: A0A1D8PR81
names: Similarity
messages: Belongs to the SAPS family.

237561:CAALFM C400570CA
gene id: 237561:CAALFM_C400570CA
uniprot id: Q59SI6
names: Similarity
messages: Belongs to the cytidylyltransferase family.

237561:CAALFM C301460CA
gene id: 237561:CAALFM_C301460CA
uniprot id: Q5AJ90
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

237561:CAALFM C500320WA
gene id: 237561:CAALFM_C500320WA
uniprot id: A0A1D8PMX3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

237561:CAALFM C404550CA
gene id: 237561:CAALFM_C404550CA
uniprot id: Q5A663
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.
messages: Cells are resistant to rapamycin and display reduced TOR signaling.
messages: Mitochondrion inner membrane
messages: Protease activity is induced in response to various mitochondrial stress.
messages: Protease that is part of the quality control system in the inner membrane of mitochondria (By similarity). Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein (By similarity). Required for TOR signaling (PubMed:27325672).

237561:CAALFM C210440CA
gene id: 237561:CAALFM_C210440CA
uniprot id: A0A1D8PIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

237561:CAALFM C206770WA
gene id: 237561:CAALFM_C206770WA
uniprot id: A0A1D8PHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

237561:CAALFM C702000CA
gene id: 237561:CAALFM_C702000CA
uniprot id: A0A1D8PQZ7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C702050CA
gene id: 237561:CAALFM_C702050CA
uniprot id: Q5AH25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).

237561:CAALFM C204780WA
gene id: 237561:CAALFM_C204780WA
uniprot id: A0A1D8PH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

237561:CAALFM CR00120CA
gene id: 237561:CAALFM_CR00120CA
uniprot id: Q5AAG6
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
messages: Activated through phosphorylation of Thr-211 and Tyr-213 from the TXY motif (By similarity). Phosphorylated in a PKC1-dependent manner in response to cell wall perturbations, oxidative stress, osmotic stress, and low temperatures. Also activated in response to physical contact leading to contact-dependent cellular behaviors such as invasive hyphal growth and biofilm development. Phosphorylation is also PBS2- and HOG1-dependent.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Expression is up-regulated by caspofungin.
messages: Leads to thermosensitive growth, enhanced caffeine and caspofungin sensitivity, and alterations of cell surfaces. Leads also to a decreased pathogenicity in mice through displaying a greater susceptibility to nitric oxide (NO), a reduced inhibitory effect on macrophage NO production, and an increased capacity of macrophage stimulation by cell wall extracts.
messages: Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

237561:CAALFM CR10810CA
gene id: 237561:CAALFM_CR10810CA
uniprot id: A0A1D8PUC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

237561:CAALFM C600870CA
gene id: 237561:CAALFM_C600870CA
uniprot id: A0A1D8PPG7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

237561:CAALFM C304550CA
gene id: 237561:CAALFM_C304550CA
uniprot id: Q5ANJ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C204990WA
gene id: 237561:CAALFM_C204990WA
uniprot id: Q59ZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD7 family.
messages: spindle pole

237561:CAALFM C204130WA
gene id: 237561:CAALFM_C204130WA
uniprot id: A0A1D8PH30
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR00740CA
gene id: 237561:CAALFM_CR00740CA
uniprot id: Q5A846
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction.
messages: Expression is induced in biofilm and by HAP43.
messages: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
messages: Membrane

237561:CAALFM C307150CA
gene id: 237561:CAALFM_C307150CA
uniprot id: Q5ADQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C300760WA
gene id: 237561:CAALFM_C300760WA
uniprot id: A0A1D8PJ25
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: C-24(28) sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). Catalyzes the last step of ergosterol biosynthesis by converting ergosta-5,7,22,24(28)-tetraen-3beta-ol into ergosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of th…
messages: Endoplasmic reticulum membrane
messages: Expression is induced by fluconazole and repressed by caspofungin (PubMed:15917516). Expression is also repressed during biofilm formation (PubMed:19527170).

237561:CAALFM C104030WA
gene id: 237561:CAALFM_C104030WA
uniprot id: A0A1D8PD81
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

237561:CAALFM C401250WA
gene id: 237561:CAALFM_C401250WA
uniprot id: A0A1D8PLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM CR00080WA
gene id: 237561:CAALFM_CR00080WA
uniprot id: A0A1D8PRL4
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

237561:CAALFM C201180WA
gene id: 237561:CAALFM_C201180WA
uniprot id: A0A1D8PGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

237561:CAALFM C603660CA
gene id: 237561:CAALFM_C603660CA
uniprot id: A0A1D8PQ78
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

237561:CAALFM C405090CA
gene id: 237561:CAALFM_C405090CA
uniprot id: A0A1D8PM80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

237561:CAALFM C300420WA
gene id: 237561:CAALFM_C300420WA
uniprot id: Q5A7P2
names: Similarity
messages: Belongs to the RNase Z family.

237561:CAALFM CR07400CA
gene id: 237561:CAALFM_CR07400CA
uniprot id: Q59RQ6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

237561:CAALFM C504260WA
gene id: 237561:CAALFM_C504260WA
uniprot id: Q5AKB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Cytoplasm
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
messages: Vacuole lumen

237561:CAALFM C110280CA
gene id: 237561:CAALFM_C110280CA
uniprot id: Q5AP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Mitochondrion outer membrane

237561:CAALFM CR01540WA
gene id: 237561:CAALFM_CR01540WA
uniprot id: A0A1D8PS09
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

237561:CAALFM C103310WA
gene id: 237561:CAALFM_C103310WA
uniprot id: A0A1D8PCZ5
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM C500890CA
gene id: 237561:CAALFM_C500890CA
uniprot id: A0A1D8PN12
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: In contrast to the other glycerophosphodiester transporters, expression is largely unresponsive to phosphate levels (PubMed:24114876).
messages: Probable glycerophosphodiester transporter (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). Might be involved in the uptake of glycerophosphocholine (GroPCho) (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).
messages: Triple deletion of GIT2, GIT3 and GIT4 impairs the uptake of glycerophosphocholine (GroPCho) and reduces virulence in a mouse model of blood stream infection (PubMed:24114876).

237561:CAALFM C403180WA
gene id: 237561:CAALFM_C403180WA
uniprot id: A0A1D8PLR7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

237561:CAALFM C303250WA
gene id: 237561:CAALFM_C303250WA
uniprot id: A0A1D8PJN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

237561:CAALFM C406140CA
gene id: 237561:CAALFM_C406140CA
uniprot id: A0A1D8PMH0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504700CA
gene id: 237561:CAALFM_C504700CA
uniprot id: A0A1D8PP21
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C110330CA
gene id: 237561:CAALFM_C110330CA
uniprot id: Q5AP59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton

237561:CAALFM C111870WA
gene id: 237561:CAALFM_C111870WA
uniprot id: Q5A3J0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C206420CA
gene id: 237561:CAALFM_C206420CA
uniprot id: Q59Q44
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

237561:CAALFM C501350WA
gene id: 237561:CAALFM_C501350WA
uniprot id: A0A1D8PN55
names: Subcellular Location Annotation
messages: Peroxisome membrane

237561:CAALFM C210610WA
gene id: 237561:CAALFM_C210610WA
uniprot id: A0A1D8PIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C112220WA
gene id: 237561:CAALFM_C112220WA
uniprot id: A0A1D8PFB8
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

237561:CAALFM C207600CA
gene id: 237561:CAALFM_C207600CA
uniprot id: A0A1D8PHY1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C110140CA
gene id: 237561:CAALFM_C110140CA
uniprot id: Q5APS5
names: Function
messages: F-box protein probably involved in ubiquitin conjugation pathway.

237561:CAALFM C500270WA
gene id: 237561:CAALFM_C500270WA
uniprot id: Q5A4X8
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA14 family.
messages: Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process.
messages: Induced during cell wall regeneration and upon milbemycins A3 oxim derivative (A3Ox) treatment. Expression is also regulated by SSN6.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C303180CA
gene id: 237561:CAALFM_C303180CA
uniprot id: A0A1D8PJL8
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

237561:CAALFM C206660WA
gene id: 237561:CAALFM_C206660WA
uniprot id: A0A1D8PHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

237561:CAALFM C106260WA
gene id: 237561:CAALFM_C106260WA
uniprot id: Q59MD0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C104170CA
gene id: 237561:CAALFM_C104170CA
uniprot id: Q59VP2
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-5; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-128.

237561:CAALFM C305350CA
gene id: 237561:CAALFM_C305350CA
uniprot id: A0A1D8PK79
names: Similarity
messages: Belongs to the KNR4/SMI1 family.

237561:CAALFM C210140WA
gene id: 237561:CAALFM_C210140WA
uniprot id: A0A1D8PIP6
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM CR05290WA
gene id: 237561:CAALFM_CR05290WA
uniprot id: P87207
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Membrane
messages: Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

237561:CAALFM CR09600CA
gene id: 237561:CAALFM_CR09600CA
uniprot id: A0A1D8PU06
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

237561:CAALFM C107510WA
gene id: 237561:CAALFM_C107510WA
uniprot id: A0A1D8PE30
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

237561:CAALFM C303550CA
gene id: 237561:CAALFM_C303550CA
uniprot id: Q5AEB5
names: Similarity
messages: Belongs to the peptidase C48 family.

237561:CAALFM C304080WA
gene id: 237561:CAALFM_C304080WA
uniprot id: A0A1D8PJT8
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

237561:CAALFM C105230WA
gene id: 237561:CAALFM_C105230WA
uniprot id: Q5A298
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

237561:CAALFM CR03960CA
gene id: 237561:CAALFM_CR03960CA
uniprot id: Q5A723
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: Prevacuolar compartment membrane
messages: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
messages: Vacuole membrane
messages: multivesicular body membrane

237561:CAALFM C703070CA
gene id: 237561:CAALFM_C703070CA
uniprot id: A0A1D8PR83
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

237561:CAALFM C200720CA
gene id: 237561:CAALFM_C200720CA
uniprot id: Q5AD13
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Affects filamentous growths and leads to hypersensitivity to caspofungin.
messages: Induced by caspofungin.
messages: Nucleus
messages: Probable transcription factor involved in the regulation of filamentous growth.

237561:CAALFM C500820WA
gene id: 237561:CAALFM_C500820WA
uniprot id: Q59X93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

237561:CAALFM C106610CA
gene id: 237561:CAALFM_C106610CA
uniprot id: A0A1D8PDU7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109260CA
gene id: 237561:CAALFM_C109260CA
uniprot id: A0A1D8PEN6
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM C202570WA
gene id: 237561:CAALFM_C202570WA
uniprot id: A0A1D8PGN2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C102480WA
gene id: 237561:CAALFM_C102480WA
uniprot id: P31353
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

237561:CAALFM C604040CA
gene id: 237561:CAALFM_C604040CA
uniprot id: Q59LF3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.
messages: Leads to defects in actin polarization, endocytosis, bud morphogenesis, as well as altered abundance and distribution of the cortical actin patches and increased sensitivity to calcofluor white and Congo red. Shows also attenuated virulence.
messages: cytoskeleton

237561:CAALFM C505480WA
gene id: 237561:CAALFM_C505480WA
uniprot id: Q5AJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides. Required for the formation of the monounsaturated sphingoid base (E)-sphing-4-enine during glucosylceramide (GluCer) biosynthesis.
messages: Membrane

237561:CAALFM C401520CA
gene id: 237561:CAALFM_C401520CA
uniprot id: A0A1D8PLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C209290WA
gene id: 237561:CAALFM_C209290WA
uniprot id: A0A1D8PIG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

237561:CAALFM C700570WA
gene id: 237561:CAALFM_C700570WA
uniprot id: A0A1D8PQM4
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C200680CA
gene id: 237561:CAALFM_C200680CA
uniprot id: Q5AD07
names: Activity Regulation
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the beta-barrel of Cu/Zn SODs is largely preserved, SOD5 is a monomeric copper protein that lacks a zinc-binding site and is missing the electrostatic loop element proposed to promote catalysis through superoxide guidance. Without an electrostatic loop, the copper site of SOD5 is not recessed and is readily accessible to bulk solvent (PubMed:24711423).
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Induced during yeast-to-hyphal transition and by osmotic and oxidative stresses. Expression is also increased when cells were grown on nonfermentable substrates as the only carbon source, in serum, and in the presence of neutrophils. Down-regulated by shikonin. Expression is controlled by EFG1, NRG1 and RIM101.
messages: Leads to sensitivity to hydrogen peroxide when cells were grown in nutrient-limited conditions.
messages: Membrane
messages: Monomer.
messages: Secreted in a disulfide-oxidized form and apo-pools of secreted SOD5 can readily capture extracellular copper for rapid induction of enzyme activity.
messages: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. The unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellular copper, make these SODs well suited to meet challenges in zinc and copper availability at the host-pathogen interface.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C200220CA
gene id: 237561:CAALFM_C200220CA
uniprot id: A0A1D8PG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

237561:CAALFM CR02070CA
gene id: 237561:CAALFM_CR02070CA
uniprot id: A0A1D8PS45
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C112630CA
gene id: 237561:CAALFM_C112630CA
uniprot id: Q59PD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C105720WA
gene id: 237561:CAALFM_C105720WA
uniprot id: A0A1D8PDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR02910WA
gene id: 237561:CAALFM_CR02910WA
uniprot id: Q5A1Z5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Cytoplasm
messages: Expression is induced during biofilm formation.
messages: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
messages: Plays a key role in autophagy (PubMed:36476055). Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, plays an important role in biofilm formation and resistance to antifungal compounds such as fluconazole, itraconazole, terbinafine and caspofungin (PubMed:36476055).
messages: Preautophagosomal structure
messages: Reduces the formation of biofilms (PubMed:36476055). Significantly decreases the resistance of biofilms to fluconazole, itraconazole, terbinafine and caspofungin (PubMed:36476055). Leads to autophagosomes with shrunken membranes with undefined edges (PubMed:36476055). Results also in partially dissolved contents of autophagosomes (PubMed:36476055).

237561:CAALFM C103900WA
gene id: 237561:CAALFM_C103900WA
uniprot id: A0A1D8PD63
names: Similarity
messages: Belongs to the SEN15 family.

237561:CAALFM C601370WA
gene id: 237561:CAALFM_C601370WA
uniprot id: Q5A4J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).

237561:CAALFM CR00220WA
gene id: 237561:CAALFM_CR00220WA
uniprot id: A0A1D8PRP5
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM C210680WA
gene id: 237561:CAALFM_C210680WA
uniprot id: Q5A5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

237561:CAALFM C305580CA
gene id: 237561:CAALFM_C305580CA
uniprot id: A0A1D8PK89
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease with broad substrate specificity (PubMed:21764911, PubMed:28028545). GAP2 is the only amino-acid permease with very broad substrate specificity, none of the other GAP permeases is able to transport such a variety of amino acids (PubMed:21764911, PubMed:28028545). GAP2 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911). Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:14871944, PubMed:28028545). Induced during biofilm development (PubMed:22265407). Expression is repressed by nitrogen sources (PubMed:28028545). Expression is repressed by the antifungal agents ketoconazole and flucytosine (PubMed:15917516). Expression is also regulated by NRG1 and TUP1 (PubMed:15814841).
messages: Leads to a growth defect on medium containing phenylalanine, valine, leucine, or methionine as sole nitrogen source (PubMed:28028545).

237561:CAALFM C603100WA
gene id: 237561:CAALFM_C603100WA
uniprot id: Q5ABV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHE3 family.
messages: Endoplasmic reticulum membrane
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity).

237561:CAALFM C405570CA
gene id: 237561:CAALFM_C405570CA
uniprot id: A0A1D8PMD4
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.

237561:CAALFM C304360WA
gene id: 237561:CAALFM_C304360WA
uniprot id: A0A1D8PJZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

237561:CAALFM C210070WA
gene id: 237561:CAALFM_C210070WA
uniprot id: A0A1D8PIL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C203280WA
gene id: 237561:CAALFM_C203280WA
uniprot id: A0A1D8PGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin NSP1/NUP62 family.
messages: Nucleus membrane

237561:CAALFM C406800WA
gene id: 237561:CAALFM_C406800WA
uniprot id: Q5A0W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

237561:CAALFM CR07730WA
gene id: 237561:CAALFM_CR07730WA
uniprot id: A0A1D8PTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR10430CA
gene id: 237561:CAALFM_CR10430CA
uniprot id: A0A1D8PU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Nucleus

237561:CAALFM C200780WA
gene id: 237561:CAALFM_C200780WA
uniprot id: Q5AD21
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

237561:CAALFM C702020WA
gene id: 237561:CAALFM_C702020WA
uniprot id: P53709
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Involved in DNA excision repair.
messages: Nucleus

237561:CAALFM CR08330WA
gene id: 237561:CAALFM_CR08330WA
uniprot id: Q5A363
names: Similarity
messages: Belongs to the OPI10 family.

237561:CAALFM C702970WA
gene id: 237561:CAALFM_C702970WA
uniprot id: Q5A5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C206830CA
gene id: 237561:CAALFM_C206830CA
uniprot id: Q59ZC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.
messages: Interacts with IFH1 and TBF1.
messages: Nucleus

237561:CAALFM C701570CA
gene id: 237561:CAALFM_C701570CA
uniprot id: Q5AGW9
names: Function
names: Similarity
messages: Belongs to the NUP family.
messages: Nucleoside permease that transports adenosine and guanosine.

237561:CAALFM C701450CA
gene id: 237561:CAALFM_C701450CA
uniprot id: Q5AGV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

237561:CAALFM C500150CA
gene id: 237561:CAALFM_C500150CA
uniprot id: A0A1D8PMU8
names: Similarity
messages: Belongs to the importin alpha family.

237561:CAALFM C401320CA
gene id: 237561:CAALFM_C401320CA
uniprot id: A0A1D8PLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM CR08540CA
gene id: 237561:CAALFM_CR08540CA
uniprot id: Q5A341
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S64 family.
messages: Cell membrane
messages: Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.
messages: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.

237561:CAALFM C106810WA
gene id: 237561:CAALFM_C106810WA
uniprot id: O13289
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Homotetramer.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Required for hyphal growth.
messages: Peroxisome

237561:CAALFM C406380WA
gene id: 237561:CAALFM_C406380WA
uniprot id: P87218
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Unknown. The enzyme has no activity toward sorbose.

237561:CAALFM C505380WA
gene id: 237561:CAALFM_C505380WA
uniprot id: A0A1D8PP77
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

237561:CAALFM C402600CA
gene id: 237561:CAALFM_C402600CA
uniprot id: A0A1D8PLL1
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C404150CA
gene id: 237561:CAALFM_C404150CA
uniprot id: Q5A5V6
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

237561:CAALFM CR10640WA
gene id: 237561:CAALFM_CR10640WA
uniprot id: A0A1D8PU98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

237561:CAALFM C503460CA
gene id: 237561:CAALFM_C503460CA
uniprot id: Q59QT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

237561:CAALFM C602000WA
gene id: 237561:CAALFM_C602000WA
uniprot id: A0A1D8PPS2
names: Similarity
messages: Belongs to the lysophospholipase family.

237561:CAALFM C100770CA
gene id: 237561:CAALFM_C100770CA
uniprot id: Q5ABP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity).

237561:CAALFM C503270WA
gene id: 237561:CAALFM_C503270WA
uniprot id: Q59QS1
names: Similarity
messages: Belongs to the GST superfamily.

237561:CAALFM C100670CA
gene id: 237561:CAALFM_C100670CA
uniprot id: Q5ABD2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C702550CA
gene id: 237561:CAALFM_C702550CA
uniprot id: Q5AH78
names: Similarity
messages: Belongs to the MIP18 family.

237561:CAALFM CR07790CA
gene id: 237561:CAALFM_CR07790CA
uniprot id: Q59MV9
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the globin family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b group per subunit.
messages: Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: Cytoplasm
messages: Expression is under the control of the CDA4 transcription factor. Induced by nitric oxide, high-iron conditions, during transition to filamentous growth, by contact with host macrophages, and during oral infection. Expression is repressed by HAP43 and CWT1.
messages: Inhibited by imidazoles.
messages: Leads to increased susceptibility to neutrophils.
messages: Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system.

237561:CAALFM C203050WA
gene id: 237561:CAALFM_C203050WA
uniprot id: Q5A0L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).

237561:CAALFM C210790CA
gene id: 237561:CAALFM_C210790CA
uniprot id: Q5A5N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).
messages: Nucleus membrane

237561:CAALFM C108920WA
gene id: 237561:CAALFM_C108920WA
uniprot id: Q5AQ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU).
messages: Mitochondrion

237561:CAALFM C704230WA
gene id: 237561:CAALFM_C704230WA
uniprot id: Q5A0E5
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Down-regulated during filament induction and in response to serum at 37 degrees Celsius. Expression of NRG1 is also repressed by RIM101 and under conditions that repress CDC28 expression. The bacterial signaling molecules indole and its derivate indole-3-acetonitrile (IAN) increase NRG1 expression.
messages: Exhibits a high degree of filamentous growth and leads to avirulence in a mouse model.
messages: Nucleus
messages: Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Plays a key role in biofilm formation and dispersion. Also plays the role of a negative regulator of virulence in mice models. Required for the expression of the cell wall genes RBR1.

237561:CAALFM C106580WA
gene id: 237561:CAALFM_C106580WA
uniprot id: A0A1D8PDU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C207350WA
gene id: 237561:CAALFM_C207350WA
uniprot id: A0A1D8PHW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

237561:CAALFM C205830CA
gene id: 237561:CAALFM_C205830CA
uniprot id: Q59MG2
names: Similarity
messages: Belongs to the SHQ1 family.

237561:CAALFM C106940CA
gene id: 237561:CAALFM_C106940CA
uniprot id: Q5AAU5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 65 family.
messages: Cell wall acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Plays a role in dimorphic conversion and virulence.
messages: Expression is repressed by glucose and by HAP43.
messages: Lacks acid trehalase activity and decreases hypha formation and infectivity.
messages: cell wall

237561:CAALFM C205360CA
gene id: 237561:CAALFM_C205360CA
uniprot id: Q59ZF3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C400150CA
gene id: 237561:CAALFM_C400150CA
uniprot id: O74711
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.
messages: Monoubiquitinated at Cys-10 by PEX2 during PEX5 passage through the retrotranslocation channel: monoubiquitination acts as a signal for PEX5 extraction and is required for proper export from peroxisomes and recycling. When PEX5 recycling is compromised, polyubiquitinated at Lys-22 by PEX10 during its passage through the retrotranslocation channel, leading to its degradation.
messages: Peroxisome matrix
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
messages: The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).
messages: The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.
messages: The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.
messages: cytosol

237561:CAALFM C700740WA
gene id: 237561:CAALFM_C700740WA
uniprot id: A0A1D8PQP3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C301760WA
gene id: 237561:CAALFM_C301760WA
uniprot id: Q5AJC2
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

237561:CAALFM C106570WA
gene id: 237561:CAALFM_C106570WA
uniprot id: Q5AAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C103650CA
gene id: 237561:CAALFM_C103650CA
uniprot id: Q5AHY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

237561:CAALFM C202460WA
gene id: 237561:CAALFM_C202460WA
uniprot id: Q04782
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the terpene cyclase/mutase family.
messages: Endoplasmic reticulum membrane
messages: Expression is induced in the presence of fluconazole (PubMed:15820985). Expression is up-regulated when ERG6, CYP51/ERG11 or ERG24 are deleted (PubMed:15473366).
messages: Lanosterol synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:8486282, PubMed:2185141). ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core (PubMed:2185141). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of t…
messages: Lipid droplet

237561:CAALFM CR03450WA
gene id: 237561:CAALFM_CR03450WA
uniprot id: A0A1D8PSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C205150WA
gene id: 237561:CAALFM_C205150WA
uniprot id: Q59ZH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

237561:CAALFM CR07130CA
gene id: 237561:CAALFM_CR07130CA
uniprot id: Q59K96
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM CR05160CA
gene id: 237561:CAALFM_CR05160CA
uniprot id: Q59QN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

237561:CAALFM C111690WA
gene id: 237561:CAALFM_C111690WA
uniprot id: Q59TU4
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C114210CA
gene id: 237561:CAALFM_C114210CA
uniprot id: Q59ZW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IML2 family.
messages: Cytoplasm
messages: Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
messages: Interacts with lipid droplet proteins.
messages: Nucleus

237561:CAALFM C204500WA
gene id: 237561:CAALFM_C204500WA
uniprot id: A0A1D8PH70
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C500370WA
gene id: 237561:CAALFM_C500370WA
uniprot id: A0A1D8PMW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Nucleus matrix
messages: cytoskeleton

237561:CAALFM C601160WA
gene id: 237561:CAALFM_C601160WA
uniprot id: A0A1D8PPK4
names: Similarity
messages: Belongs to the RCAN family.

237561:CAALFM C600530CA
gene id: 237561:CAALFM_C600530CA
uniprot id: A0A1D8PPC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

237561:CAALFM CR04260WA
gene id: 237561:CAALFM_CR04260WA
uniprot id: A0A1D8PSP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

237561:CAALFM C109670CA
gene id: 237561:CAALFM_C109670CA
uniprot id: Q5APD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

237561:CAALFM C104320WA
gene id: 237561:CAALFM_C104320WA
uniprot id: Q59VM6
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

237561:CAALFM C401370WA
gene id: 237561:CAALFM_C401370WA
uniprot id: A0A1D8PLB7
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

237561:CAALFM C701190WA
gene id: 237561:CAALFM_C701190WA
uniprot id: A0A1D8PQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Cytoplasm

237561:CAALFM C102220CA
gene id: 237561:CAALFM_C102220CA
uniprot id: Q59VX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Mitochondrion

237561:CAALFM C403380CA
gene id: 237561:CAALFM_C403380CA
uniprot id: A0A1D8PLT7
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

237561:CAALFM CR01750CA
gene id: 237561:CAALFM_CR01750CA
uniprot id: P0CY31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity).
messages: secretory vesicle membrane

237561:CAALFM C500630CA
gene id: 237561:CAALFM_C500630CA
uniprot id: A0A1D8PMZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

237561:CAALFM CR04360CA
gene id: 237561:CAALFM_CR04360CA
uniprot id: Q5A6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

237561:CAALFM CR03530WA
gene id: 237561:CAALFM_CR03530WA
uniprot id: Q5A044
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

237561:CAALFM C107240WA
gene id: 237561:CAALFM_C107240WA
uniprot id: Q59WC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPD1 family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorelay intermediate protein that is part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound histidine kinase SLN1 to two distinct response regulators SSK1 and SKN7.

237561:CAALFM C602840CA
gene id: 237561:CAALFM_C602840CA
uniprot id: Q5ABZ2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBF1 family.
messages: Expression is increased in during infection. Expression is also regulated by CDC28, SKO1, and SSK1.
messages: Induces filamentous growth and leads to decreased HWP1 expression.
messages: Nucleus
messages: Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor.
messages: telomere

237561:CAALFM C303010CA
gene id: 237561:CAALFM_C303010CA
uniprot id: A0A1D8PJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

237561:CAALFM CR04280CA
gene id: 237561:CAALFM_CR04280CA
uniprot id: Q5A6N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.

237561:CAALFM C208590WA
gene id: 237561:CAALFM_C208590WA
uniprot id: Q59Y31
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization.
messages: Cleaved by SAP9 and SAP10, which leads to its release from the cell wall.
messages: Expression is greatest during yeast exponential-phase growth, but down-regulated in stationary phase and upon filamentation. Expression is also increased during growth in hypoxic conditions. Expression decreases in biofilm cultures and becomes undetectable through late stage biofilm formation. Up-regulated when the extracellular phosphate concentration is low or in presence of Cis-2-dodecenoic acid (BDSF). Repressed during cell wall regeneration. Expression is positively regulated by EFG1 and EFH1, and negatively regulated by SSN6 and SSK1.
messages: Leads to increased adhesion and biofilm formation.
messages: Membrane
messages: N-glycosylated.
messages: Secreted
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C103440CA
gene id: 237561:CAALFM_C103440CA
uniprot id: Q5AI07
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C210260CA
gene id: 237561:CAALFM_C210260CA
uniprot id: Q59XV1
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C202020WA
gene id: 237561:CAALFM_C202020WA
uniprot id: A0A1D8PGI9
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C205960CA
gene id: 237561:CAALFM_C205960CA
uniprot id: A0A1D8PHK2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

237561:CAALFM C100730CA
gene id: 237561:CAALFM_C100730CA
uniprot id: A0A1D8PCA8
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

237561:CAALFM CR10170CA
gene id: 237561:CAALFM_CR10170CA
uniprot id: A0A1D8PU58
names: Similarity
messages: Belongs to the asparaginase 1 family.

237561:CAALFM C205500WA
gene id: 237561:CAALFM_C205500WA
uniprot id: Q59ZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

237561:CAALFM CR02020CA
gene id: 237561:CAALFM_CR02020CA
uniprot id: A0A1D8PS46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM CR10770WA
gene id: 237561:CAALFM_CR10770WA
uniprot id: A0A1D8PUA5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C103460CA
gene id: 237561:CAALFM_C103460CA
uniprot id: A0A1D8PD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus

237561:CAALFM C203400CA
gene id: 237561:CAALFM_C203400CA
uniprot id: Q5AHB5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C103390WA
gene id: 237561:CAALFM_C103390WA
uniprot id: A0A1D8PD05
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

237561:CAALFM C300280CA
gene id: 237561:CAALFM_C300280CA
uniprot id: A0A1D8PIW0
names: Similarity
messages: Belongs to the peptidase C48 family.

237561:CAALFM C502540CA
gene id: 237561:CAALFM_C502540CA
uniprot id: A0A1D8PNG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

237561:CAALFM C105870WA
gene id: 237561:CAALFM_C105870WA
uniprot id: A0A1D8PDP2
names: Similarity
messages: Belongs to the pirin family.

237561:CAALFM C203330CA
gene id: 237561:CAALFM_C203330CA
uniprot id: Q92207
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme (By similarity). Phosphorylated in response to oxidative and salt stress.
messages: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program.
messages: Nucleus
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

237561:CAALFM C307180CA
gene id: 237561:CAALFM_C307180CA
uniprot id: Q5ADQ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response.
messages: Impairs the mannosylation of beta-mannose chains on the acid-stable fraction of cell wall phosphopeptidomannan.
messages: Membrane

237561:CAALFM C703850WA
gene id: 237561:CAALFM_C703850WA
uniprot id: A0A1D8PRF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

237561:CAALFM C501770CA
gene id: 237561:CAALFM_C501770CA
uniprot id: Q9UW25
names: Miscellaneous
names: Similarity
messages: Belongs to the OSBP family.
messages: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

237561:CAALFM CR07080WA
gene id: 237561:CAALFM_CR07080WA
uniprot id: Q59L13
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

237561:CAALFM C401080WA
gene id: 237561:CAALFM_C401080WA
uniprot id: Q5AMG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).

237561:CAALFM C210110WA
gene id: 237561:CAALFM_C210110WA
uniprot id: P53698
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

237561:CAALFM C206150CA
gene id: 237561:CAALFM_C206150CA
uniprot id: Q59X29
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

237561:CAALFM CR09370WA
gene id: 237561:CAALFM_CR09370WA
uniprot id: A0A1D8PTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

237561:CAALFM C401550CA
gene id: 237561:CAALFM_C401550CA
uniprot id: Q5AML6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Cytoplasm

237561:CAALFM C103110WA
gene id: 237561:CAALFM_C103110WA
uniprot id: A0A1D8PCX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C101990WA
gene id: 237561:CAALFM_C101990WA
uniprot id: Q59TA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

237561:CAALFM C100980WA
gene id: 237561:CAALFM_C100980WA
uniprot id: A0A1D8PCD7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

237561:CAALFM C102420CA
gene id: 237561:CAALFM_C102420CA
uniprot id: A0A1D8PCT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

237561:CAALFM C106000WA
gene id: 237561:CAALFM_C106000WA
uniprot id: A0A1D8PDP0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C202030WA
gene id: 237561:CAALFM_C202030WA
uniprot id: A0A1D8PGI8
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

237561:CAALFM CR03170WA
gene id: 237561:CAALFM_CR03170WA
uniprot id: Q59UF7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

237561:CAALFM CR02380CA
gene id: 237561:CAALFM_CR02380CA
uniprot id: A0A1D8PS74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

237561:CAALFM C302600CA
gene id: 237561:CAALFM_C302600CA
uniprot id: Q5AEL8
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

237561:CAALFM C110380CA
gene id: 237561:CAALFM_C110380CA
uniprot id: Q5AP53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.
messages: Bud neck
messages: Cell tip
messages: Interacts with MOB2 and BCR1.
messages: Serine/threonine-protein kinase required for wild-type hyphal growth and transcriptional regulation of cell-wall-associated genes. Involved in the biofilm formation through phosphorylation of the master regulator of biofilm formation BCR1.

237561:CAALFM C704050WA
gene id: 237561:CAALFM_C704050WA
uniprot id: A0A1D8PRI1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR04480CA
gene id: 237561:CAALFM_CR04480CA
uniprot id: Q5A6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

237561:CAALFM C113490CA
gene id: 237561:CAALFM_C113490CA
uniprot id: A0A1D8PFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

237561:CAALFM C505050WA
gene id: 237561:CAALFM_C505050WA
uniprot id: A0A1D8PP43
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C403720CA
gene id: 237561:CAALFM_C403720CA
uniprot id: A0A1D8PLW3
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

237561:CAALFM C108070WA
gene id: 237561:CAALFM_C108070WA
uniprot id: A0A1D8PE84
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C400890WA
gene id: 237561:CAALFM_C400890WA
uniprot id: Q5AME2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

237561:CAALFM C400170WA
gene id: 237561:CAALFM_C400170WA
uniprot id: Q59US8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C110160WA
gene id: 237561:CAALFM_C110160WA
uniprot id: Q5AP79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C206870CA
gene id: 237561:CAALFM_C206870CA
uniprot id: A0A1D8PHR5
names: Similarity
messages: Belongs to the WrbA family.

237561:CAALFM C303410CA
gene id: 237561:CAALFM_C303410CA
uniprot id: Q5AED0
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

237561:CAALFM C112770WA
gene id: 237561:CAALFM_C112770WA
uniprot id: Q59PL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

237561:CAALFM C205730CA
gene id: 237561:CAALFM_C205730CA
uniprot id: Q873N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

237561:CAALFM C104330WA
gene id: 237561:CAALFM_C104330WA
uniprot id: Q59VM4
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced by HAP43, by osmotic stress, by oxidative stress, by heavy metal stress, and during biofilm formation.
messages: Nucleus
messages: Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes.

237561:CAALFM CR04910WA
gene id: 237561:CAALFM_CR04910WA
uniprot id: A0A1D8PSW8
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

237561:CAALFM C500140CA
gene id: 237561:CAALFM_C500140CA
uniprot id: A0A1D8PMU1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR01660CA
gene id: 237561:CAALFM_CR01660CA
uniprot id: Q5A9A9
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C305280CA
gene id: 237561:CAALFM_C305280CA
uniprot id: Q5AN96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

237561:CAALFM C601860CA
gene id: 237561:CAALFM_C601860CA
uniprot id: A0A1D8PPR5
names: Similarity
messages: Belongs to the AHA1 family.

237561:CAALFM C403110WA
gene id: 237561:CAALFM_C403110WA
uniprot id: A0A1D8PLQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

237561:CAALFM C200300CA
gene id: 237561:CAALFM_C200300CA
uniprot id: Q5ACW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

237561:CAALFM C201950CA
gene id: 237561:CAALFM_C201950CA
uniprot id: Q5ALR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMN1 family.
messages: Cytoplasm
messages: Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.
messages: Nucleus

237561:CAALFM C703180CA
gene id: 237561:CAALFM_C703180CA
uniprot id: A0A1D8PR93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

237561:CAALFM CR03400WA
gene id: 237561:CAALFM_CR03400WA
uniprot id: A0A1D8PSG5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C505100CA
gene id: 237561:CAALFM_C505100CA
uniprot id: A0A1D8PP50
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

237561:CAALFM C100990CA
gene id: 237561:CAALFM_C100990CA
uniprot id: A0A1D8PCD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Nuclear serine protease which mediates apoptosis.
messages: Nucleus

237561:CAALFM CR00650WA
gene id: 237561:CAALFM_CR00650WA
uniprot id: A0A1D8PRU0
names: Similarity
messages: Belongs to the peptidase S8 family.

237561:CAALFM C114010WA
gene id: 237561:CAALFM_C114010WA
uniprot id: A0A1D8PFT5
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C107090CA
gene id: 237561:CAALFM_C107090CA
uniprot id: Q5AAW5
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

237561:CAALFM CR00520CA
gene id: 237561:CAALFM_CR00520CA
uniprot id: A0A1D8PRR9
names: Similarity
messages: Belongs to the exportin family.

237561:CAALFM CR02490WA
gene id: 237561:CAALFM_CR02490WA
uniprot id: Q59LT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C110610WA
gene id: 237561:CAALFM_C110610WA
uniprot id: Q59LX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM C100100CA
gene id: 237561:CAALFM_C100100CA
uniprot id: Q5AB72
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

237561:CAALFM C700560CA
gene id: 237561:CAALFM_C700560CA
uniprot id: A0A1D8PQL3
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

237561:CAALFM C103980WA
gene id: 237561:CAALFM_C103980WA
uniprot id: Q59QH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex SPC19 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

237561:CAALFM C100500CA
gene id: 237561:CAALFM_C100500CA
uniprot id: Q5ABB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

237561:CAALFM C505490CA
gene id: 237561:CAALFM_C505490CA
uniprot id: Q5AJX0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C400820WA
gene id: 237561:CAALFM_C400820WA
uniprot id: Q59SL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C103520WA
gene id: 237561:CAALFM_C103520WA
uniprot id: A0A1D8PD15
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

237561:CAALFM C202940WA
gene id: 237561:CAALFM_C202940WA
uniprot id: A0A1D8PGS2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

237561:CAALFM CR00660WA
gene id: 237561:CAALFM_CR00660WA
uniprot id: A0A1D8PRS3
names: Similarity
messages: Belongs to the peptidase S8 family.

237561:CAALFM C106450CA
gene id: 237561:CAALFM_C106450CA
uniprot id: A0A1D8PDT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS14B is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C205480CA
gene id: 237561:CAALFM_C205480CA
uniprot id: A0A1D8PHE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC4 family.
messages: Mitochondrion intermembrane space

237561:CAALFM CR09390CA
gene id: 237561:CAALFM_CR09390CA
uniprot id: A0A1D8PTY2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C401880WA
gene id: 237561:CAALFM_C401880WA
uniprot id: Q5AMP2
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

237561:CAALFM C108220WA
gene id: 237561:CAALFM_C108220WA
uniprot id: Q5A761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C204510WA
gene id: 237561:CAALFM_C204510WA
uniprot id: Q59TD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C405780CA
gene id: 237561:CAALFM_C405780CA
uniprot id: A0A1D8PME3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201300CA
gene id: 237561:CAALFM_C201300CA
uniprot id: Q5AD72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane

237561:CAALFM C402790CA
gene id: 237561:CAALFM_C402790CA
uniprot id: A0A1D8PLN1
names: Similarity
messages: Belongs to the SAS10 family.

237561:CAALFM C113220CA
gene id: 237561:CAALFM_C113220CA
uniprot id: Q5AL27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase specific for casein kinase 1.
messages: The DHHC domain is required for palmitoyltransferase activity.

237561:CAALFM C209430WA
gene id: 237561:CAALFM_C209430WA
uniprot id: Q59LS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC (By similarity).
messages: Cytoplasm

237561:CAALFM C406150CA
gene id: 237561:CAALFM_C406150CA
uniprot id: A0A1D8PMI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

237561:CAALFM C209260CA
gene id: 237561:CAALFM_C209260CA
uniprot id: A0A1D8PID4
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

237561:CAALFM C305890WA
gene id: 237561:CAALFM_C305890WA
uniprot id: A0A1D8PKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

237561:CAALFM C207290WA
gene id: 237561:CAALFM_C207290WA
uniprot id: Q59Z14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C400470CA
gene id: 237561:CAALFM_C400470CA
uniprot id: Q59UP4
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C109180WA
gene id: 237561:CAALFM_C109180WA
uniprot id: A0A1D8PEI7
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C405070CA
gene id: 237561:CAALFM_C405070CA
uniprot id: A0A1D8PM83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix

237561:CAALFM C102860CA
gene id: 237561:CAALFM_C102860CA
uniprot id: Q5AI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Membrane

237561:CAALFM CR05650WA
gene id: 237561:CAALFM_CR05650WA
uniprot id: P43072
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIB family.
messages: General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.
messages: Nucleus
messages: TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and a 70 kDa polypeptide.

237561:CAALFM C207980WA
gene id: 237561:CAALFM_C207980WA
uniprot id: A0A1D8PI10
names: Similarity
messages: Belongs to the FAH family.

237561:CAALFM C401770WA
gene id: 237561:CAALFM_C401770WA
uniprot id: Q5AMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

237561:CAALFM C207460WA
gene id: 237561:CAALFM_C207460WA
uniprot id: Q59U67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
messages: Nucleus
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors.

237561:CAALFM CR04930WA
gene id: 237561:CAALFM_CR04930WA
uniprot id: A0A1D8PSW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

237561:CAALFM CR00100CA
gene id: 237561:CAALFM_CR00100CA
uniprot id: Q5AAG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

237561:CAALFM C105380CA
gene id: 237561:CAALFM_C105380CA
uniprot id: A0A1D8PDJ8
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

237561:CAALFM CR05090CA
gene id: 237561:CAALFM_CR05090CA
uniprot id: A0A1D8PSX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C108930CA
gene id: 237561:CAALFM_C108930CA
uniprot id: A0A1D8PEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM C111020WA
gene id: 237561:CAALFM_C111020WA
uniprot id: Q59WI9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109900WA
gene id: 237561:CAALFM_C109900WA
uniprot id: A0A1D8PEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C105000WA
gene id: 237561:CAALFM_C105000WA
uniprot id: Q59MA6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan.
messages: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
messages: Membrane
messages: Regulated on yeast-hypha and white-opaque switches, and repressed in biofilm.

237561:CAALFM CR04950WA
gene id: 237561:CAALFM_CR04950WA
uniprot id: A0A1D8PSV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C701660CA
gene id: 237561:CAALFM_C701660CA
uniprot id: Q5AGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C704200CA
gene id: 237561:CAALFM_C704200CA
uniprot id: Q5A0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).

237561:CAALFM C112660WA
gene id: 237561:CAALFM_C112660WA
uniprot id: Q59PD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAD1 family.
messages: Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.
messages: Component of the mitotic checkpoint complex (MCC).
messages: Nucleus

237561:CAALFM C503140CA
gene id: 237561:CAALFM_C503140CA
uniprot id: A0A1D8PNM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
messages: Membrane

237561:CAALFM C404870CA
gene id: 237561:CAALFM_C404870CA
uniprot id: A0A1D8PM60
names: Similarity
messages: Belongs to the PAT1 family.

237561:CAALFM C602240CA
gene id: 237561:CAALFM_C602240CA
uniprot id: Q9UVJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit (LSU) (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (Probable). uL1 forms part of the L1 stalk (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
messages: Cytoplasm

237561:CAALFM CR03180WA
gene id: 237561:CAALFM_CR03180WA
uniprot id: A0A1D8PSF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

237561:CAALFM C208080CA
gene id: 237561:CAALFM_C208080CA
uniprot id: A0A1D8PI81
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM C204870CA
gene id: 237561:CAALFM_C204870CA
uniprot id: A0A1D8PH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC2 family.
messages: Nucleus

237561:CAALFM CR01590CA
gene id: 237561:CAALFM_CR01590CA
uniprot id: A0A1D8PS03
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

237561:CAALFM C303680WA
gene id: 237561:CAALFM_C303680WA
uniprot id: A0A1D8PJQ9
names: Similarity
messages: Belongs to the group II decarboxylase family.

237561:CAALFM C603800CA
gene id: 237561:CAALFM_C603800CA
uniprot id: A0A1D8PQ93
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C108490WA
gene id: 237561:CAALFM_C108490WA
uniprot id: Q59QC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

237561:CAALFM C110780CA
gene id: 237561:CAALFM_C110780CA
uniprot id: Q59WG0
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the HINT family.
messages: Expression is decreased at the stationary phase (PubMed:17588813). Expression in suppressed in the presence of Pseudomonas aeruginosa lipopolysaccharide (LPS) (PubMed:23194472).
messages: Homodimer.
messages: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.

237561:CAALFM CR08610WA
gene id: 237561:CAALFM_CR08610WA
uniprot id: Q5A328
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR00820CA
gene id: 237561:CAALFM_CR00820CA
uniprot id: A0A1D8PRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

237561:CAALFM C205060CA
gene id: 237561:CAALFM_C205060CA
uniprot id: Q59ZI2
names: Similarity
messages: Belongs to the sulfiredoxin family.

237561:CAALFM C500190CA
gene id: 237561:CAALFM_C500190CA
uniprot id: Q5A4W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

237561:CAALFM C600660CA
gene id: 237561:CAALFM_C600660CA
uniprot id: A0A1D8PPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM CR03760WA
gene id: 237561:CAALFM_CR03760WA
uniprot id: Q5A013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

237561:CAALFM C302230CA
gene id: 237561:CAALFM_C302230CA
uniprot id: A0A1D8PJE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

237561:CAALFM C209990CA
gene id: 237561:CAALFM_C209990CA
uniprot id: A0A1D8PIM2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00480WA
gene id: 237561:CAALFM_CR00480WA
uniprot id: A0A1D8PRP9
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

237561:CAALFM C107030CA
gene id: 237561:CAALFM_C107030CA
uniprot id: Q5AB48
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Induced during the switch from the yeast form to filamentous growth and by fluconazole. Expression is negatively regulated by CPH2, EFG1, RFG1, and TUP1.
messages: Secreted
messages: Secreted protein that acts as a virulence factor during infections such as in posttraumatic corneal infections. Acts as an important antigen in patients with systemic candidiasis and plays a role in the protection against phagocyte attack.

237561:CAALFM C113050WA
gene id: 237561:CAALFM_C113050WA
uniprot id: A0A1D8PFL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL14 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C114020WA
gene id: 237561:CAALFM_C114020WA
uniprot id: A0A1D8PFU1
names: Similarity
messages: Belongs to the Rho GDI family.

237561:CAALFM C401990WA
gene id: 237561:CAALFM_C401990WA
uniprot id: A0A1D8PLE7
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

237561:CAALFM C100460WA
gene id: 237561:CAALFM_C100460WA
uniprot id: Q5ABA8
names: Similarity
messages: Belongs to the MGR2 family.

237561:CAALFM CR10470CA
gene id: 237561:CAALFM_CR10470CA
uniprot id: Q5ACL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

237561:CAALFM C302470CA
gene id: 237561:CAALFM_C302470CA
uniprot id: Q5AEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C603390WA
gene id: 237561:CAALFM_C603390WA
uniprot id: A0A1D8PQ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C504570CA
gene id: 237561:CAALFM_C504570CA
uniprot id: Q5AK79
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

237561:CAALFM C114200WA
gene id: 237561:CAALFM_C114200WA
uniprot id: A0A1D8PFU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

237561:CAALFM C603880WA
gene id: 237561:CAALFM_C603880WA
uniprot id: Q5A8I5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C504370CA
gene id: 237561:CAALFM_C504370CA
uniprot id: Q5AK97
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA37 family.
messages: Cell membrane
messages: Predicted GPI-anchored protein which may have a role during host infection.
messages: Repressed by HAP43. Down-regulated during oral epithelial infection. Up-regulated in response to galactose.

237561:CAALFM C113260WA
gene id: 237561:CAALFM_C113260WA
uniprot id: A0A1D8PFM9
names: Function
names: Similarity
messages: Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C103070CA
gene id: 237561:CAALFM_C103070CA
uniprot id: A0A1D8PCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

237561:CAALFM C107410CA
gene id: 237561:CAALFM_C107410CA
uniprot id: Q59WE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

237561:CAALFM C501290CA
gene id: 237561:CAALFM_C501290CA
uniprot id: A0A1D8PN46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

237561:CAALFM C406120WA
gene id: 237561:CAALFM_C406120WA
uniprot id: A0A1D8PMH8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

237561:CAALFM C100700WA
gene id: 237561:CAALFM_C100700WA
uniprot id: Q5ABD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

237561:CAALFM C701630WA
gene id: 237561:CAALFM_C701630WA
uniprot id: Q5AGX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

237561:CAALFM C101980WA
gene id: 237561:CAALFM_C101980WA
uniprot id: A0A1D8PCL1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in presence of 2 percent glucose (PubMed:12187386). Expression is induced by progesterone and drugs such as cycloheximide, benomyl and chloramphenicol (PubMed:10612724).
messages: High-affinity glucose transporter (PubMed:10612724, PubMed:12187386). Acts as a multifunctional complement-evasion molecule that causes down-regulation of complement activation by acquisition of human complement factors FH and C4BP (PubMed:21844307). Functions also as a human immunodeficiency virus (HIV) receptor via binding the viral gp160 protein (PubMed:21844307). Modulates hyphae formation (PubMed:21844307).
messages: Interacts with the human complement factors FH and C4BP (PubMed:21844307). Binds also human immunodeficiency virus (HIV) protein gp160 (PubMed:21844307).
messages: Reduces the binding of human FH and C4Bp as well as of human immunodeficiency virus (HIV) gp160 protein onto C.albicans cell surface (PubMed:21844307). Reduces ability to form hyphae (PubMed:21844307).

237561:CAALFM CR03070WA
gene id: 237561:CAALFM_CR03070WA
uniprot id: A0A1D8PSD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

237561:CAALFM C405390WA
gene id: 237561:CAALFM_C405390WA
uniprot id: Q59P08
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM CR05520WA
gene id: 237561:CAALFM_CR05520WA
uniprot id: Q59M49
names: Similarity
messages: Belongs to the NOC2 family.

237561:CAALFM C404570WA
gene id: 237561:CAALFM_C404570WA
uniprot id: A0A1D8PM34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C100290WA
gene id: 237561:CAALFM_C100290WA
uniprot id: A0A1D8PC70
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C108660CA
gene id: 237561:CAALFM_C108660CA
uniprot id: Q5APP1
names: Similarity
messages: Belongs to the SF3A2 family.

237561:CAALFM C114040WA
gene id: 237561:CAALFM_C114040WA
uniprot id: A0A1D8PFU6
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

237561:CAALFM C402370CA
gene id: 237561:CAALFM_C402370CA
uniprot id: Q5AF39
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HWP1 family.
messages: Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation.
messages: Leads to an altered cell wall structure with a less electron dense inner layer of the cell wall, and a disorganized outer layer.
messages: Membrane
messages: N- and O-glycosylated.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Up-regulated during cell wall regeneration and down-regulated in kidney lesions. Expression is also regulated by HAP43 and SSN6.
messages: cell wall

237561:CAALFM C114390WA
gene id: 237561:CAALFM_C114390WA
uniprot id: A0A1D8PFX2
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

237561:CAALFM C107250CA
gene id: 237561:CAALFM_C107250CA
uniprot id: A0A1D8PE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C203080WA
gene id: 237561:CAALFM_C203080WA
uniprot id: A0A1D8PGS5
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

237561:CAALFM C702920WA
gene id: 237561:CAALFM_C702920WA
uniprot id: A0A1D8PR62
names: Similarity
messages: Belongs to the amidase family.

237561:CAALFM C505000CA
gene id: 237561:CAALFM_C505000CA
uniprot id: A0A1D8PP40
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

237561:CAALFM C602350CA
gene id: 237561:CAALFM_C602350CA
uniprot id: Q59S63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Binds 1 zinc ion per subunit.
messages: Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.
messages: Nucleus

237561:CAALFM C202780CA
gene id: 237561:CAALFM_C202780CA
uniprot id: A0A1D8PGP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C209670CA
gene id: 237561:CAALFM_C209670CA
uniprot id: Q59YD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

237561:CAALFM C101680CA
gene id: 237561:CAALFM_C101680CA
uniprot id: Q5A8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS41 is involved in telomere length regulation.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU).
messages: Mitochondrion

237561:CAALFM C110390CA
gene id: 237561:CAALFM_C110390CA
uniprot id: A0A1D8PEV4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Candida albicans is resistant to cycloheximide (CHX), which binds to the ribosomal E-tRNA binding site (E-site). This resistance is caused by a natural substitution P56Q in ribosomal protein RPL42, which decreases the volume of the binding pocket and prevents the binding of inhibitors such as CHX.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C201150WA
gene id: 237561:CAALFM_C201150WA
uniprot id: A0A1D8PGB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

237561:CAALFM C702680WA
gene id: 237561:CAALFM_C702680WA
uniprot id: Q59LZ9
names: Similarity
messages: Belongs to the Tom22 family.

237561:CAALFM C107440WA
gene id: 237561:CAALFM_C107440WA
uniprot id: A0A1D8PE20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

237561:CAALFM C404810CA
gene id: 237561:CAALFM_C404810CA
uniprot id: Q5A692
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with TRM82.
messages: Nucleus

237561:CAALFM C100180WA
gene id: 237561:CAALFM_C100180WA
uniprot id: Q5AB87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C107200WA
gene id: 237561:CAALFM_C107200WA
uniprot id: Q59WC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM CR00560WA
gene id: 237561:CAALFM_CR00560WA
uniprot id: A0A1D8PRR3
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

237561:CAALFM C500200CA
gene id: 237561:CAALFM_C500200CA
uniprot id: Q5A4W8
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is regulated by FKH2 and repressed upon adherence to polystyrene and interaction with macrophages.
messages: Nucleus
messages: Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

237561:CAALFM C108990CA
gene id: 237561:CAALFM_C108990CA
uniprot id: A0A1D8PEG3
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

237561:CAALFM C202000WA
gene id: 237561:CAALFM_C202000WA
uniprot id: A0A1D8PGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

237561:CAALFM C604350CA
gene id: 237561:CAALFM_C604350CA
uniprot id: Q59QW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FLO8 family.
messages: Interacts with EFG1 and MSS11.
messages: Nucleus
messages: Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections.

237561:CAALFM C104260WA
gene id: 237561:CAALFM_C104260WA
uniprot id: Q59VN2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

237561:CAALFM CR04720CA
gene id: 237561:CAALFM_CR04720CA
uniprot id: Q59KI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

237561:CAALFM C200600CA
gene id: 237561:CAALFM_C200600CA
uniprot id: A0A1D8PG46
names: Similarity
messages: Belongs to the NifU family.

237561:CAALFM C402230CA
gene id: 237561:CAALFM_C402230CA
uniprot id: P86029
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the intradiol ring-cleavage dioxygenase family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: By phenol.
messages: Can cleave 4-methylcatechol at lower rates than catechol, but has no activity with 3-methylcatechol, 4-chlorocatechol, 4-carboxycatechol or hydroxyquinol.
messages: Homodimer.
messages: Inhibited by Ag(+), Cu(+), Hg(2+) and Pb(2+).

237561:CAALFM C402090CA
gene id: 237561:CAALFM_C402090CA
uniprot id: Q5AMR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

237561:CAALFM C501240WA
gene id: 237561:CAALFM_C501240WA
uniprot id: O13332
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUR1 family.
messages: Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.
messages: Golgi stack membrane
messages: Inhibited by aureobasidin A (AbA), khafrefungin and rustmicin.

237561:CAALFM C108980CA
gene id: 237561:CAALFM_C108980CA
uniprot id: A0A1D8PEG2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

237561:CAALFM C106280CA
gene id: 237561:CAALFM_C106280CA
uniprot id: Q59MD2
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promotes filamentous biofilms and is required for adherence to surfaces such as plastic. Plays an important role in virulence.
messages: Leads to attenuated virulence and defective hyphal extension in a mouse model of systemic candidiasis.
messages: Nucleus
messages: Up-regulated during growth in alkaline conditions, in response to various filament-inducing conditions, and during oropharyngeal candidiasis. Induced in both white and opaque cells. Induced by SFL2 and repressed by RFG1, SFL1, and by NRG1 under non-filament-inducing conditions. Also repressed by linalool. Expression is also regulated by BRG1 and EFG1.

237561:CAALFM CR03680CA
gene id: 237561:CAALFM_CR03680CA
uniprot id: A0A1D8PSI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

237561:CAALFM C305040CA
gene id: 237561:CAALFM_C305040CA
uniprot id: Q5ANC9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
messages: Golgi apparatus membrane
messages: Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.
messages: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation (PubMed:17185534). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity).
messages: Phosphorylated by ATG1. ATG1 phosphorylation is required for preautophagosome elongation.
messages: Preautophagosomal structure membrane

237561:CAALFM C204950CA
gene id: 237561:CAALFM_C204950CA
uniprot id: A0A1D8PHA3
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C202640CA
gene id: 237561:CAALFM_C202640CA
uniprot id: A0A1D8PGM8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C101950CA
gene id: 237561:CAALFM_C101950CA
uniprot id: Q59TA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C100930CA
gene id: 237561:CAALFM_C100930CA
uniprot id: A0A1D8PCC3
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C406400CA
gene id: 237561:CAALFM_C406400CA
uniprot id: P87220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

237561:CAALFM CR08300CA
gene id: 237561:CAALFM_CR08300CA
uniprot id: Q5A368
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by organophosphorus esters.
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).

237561:CAALFM C205650WA
gene id: 237561:CAALFM_C205650WA
uniprot id: Q59T42
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

237561:CAALFM C110800CA
gene id: 237561:CAALFM_C110800CA
uniprot id: Q59WG4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C113770CA
gene id: 237561:CAALFM_C113770CA
uniprot id: Q5AKW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Membrane
messages: Mitochondrion

237561:CAALFM C500950CA
gene id: 237561:CAALFM_C500950CA
uniprot id: Q5A1M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Putative protein lysine methyltransferase.

237561:CAALFM C700050CA
gene id: 237561:CAALFM_C700050CA
uniprot id: A0A1D8PQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

237561:CAALFM C401260WA
gene id: 237561:CAALFM_C401260WA
uniprot id: A0A1D8PL95
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR08990CA
gene id: 237561:CAALFM_CR08990CA
uniprot id: A0A1D8PTU3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

237561:CAALFM C306350WA
gene id: 237561:CAALFM_C306350WA
uniprot id: Q5A2Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM CR03030CA
gene id: 237561:CAALFM_CR03030CA
uniprot id: A0A1D8PSC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR03800CA
gene id: 237561:CAALFM_CR03800CA
uniprot id: A0A1D8PSJ8
names: Similarity
messages: Belongs to the PPP phosphatase family.

237561:CAALFM CR03390CA
gene id: 237561:CAALFM_CR03390CA
uniprot id: A0A1D8PSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: telomere

237561:CAALFM CR06000WA
gene id: 237561:CAALFM_CR06000WA
uniprot id: A0A1D8PT45
names: Similarity
messages: Belongs to the TCP11 family.

237561:CAALFM CR00710CA
gene id: 237561:CAALFM_CR00710CA
uniprot id: Q5A845
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C107460CA
gene id: 237561:CAALFM_C107460CA
uniprot id: Q59PU4
names: Similarity
messages: Belongs to the peptidase C13 family.

237561:CAALFM C503710CA
gene id: 237561:CAALFM_C503710CA
uniprot id: Q59N64
names: Similarity
messages: Belongs to the PhyH family.

237561:CAALFM C503700CA
gene id: 237561:CAALFM_C503700CA
uniprot id: P0CU37
uniprot id: Q59NX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diphthine synthase family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

237561:CAALFM C101860WA
gene id: 237561:CAALFM_C101860WA
uniprot id: Q59T94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

237561:CAALFM C703960CA
gene id: 237561:CAALFM_C703960CA
uniprot id: A0A1D8PRH3
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C113400CA
gene id: 237561:CAALFM_C113400CA
uniprot id: Q5AL11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C105760CA
gene id: 237561:CAALFM_C105760CA
uniprot id: Q5AA09
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis.
messages: Induced during cell wall regeneration. Expression is also increased under high-iron conditions. Repressed by the HAP43 transcription factor.
messages: Leads to hyperfilamentation, increased biofilm formation and reduced virulence in a mouse model of disseminated candidiasis. Leads also to increased susceptibility to antifungals (fluconazol, posaconazol or amphotericin B) that target the plasma membrane and to altered sensitivities to environmental (heat, osmotic and oxidative) stresses.

237561:CAALFM C111280WA
gene id: 237561:CAALFM_C111280WA
uniprot id: Q59W50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the RRM CWC2 family.
messages: Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).
messages: Nucleus
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

237561:CAALFM C209680WA
gene id: 237561:CAALFM_C209680WA
uniprot id: A0A1D8PIH1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C208490WA
gene id: 237561:CAALFM_C208490WA
uniprot id: Q59Y20
names: Function
names: Similarity
messages: Belongs to the WD repeat DSE1 family.
messages: Involved in cell wall metabolism and required for the separation of the mother and daughter cells.

237561:CAALFM C200810CA
gene id: 237561:CAALFM_C200810CA
uniprot id: Q5AD24
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

237561:CAALFM C202540WA
gene id: 237561:CAALFM_C202540WA
uniprot id: A0A1D8PGR5
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C502050WA
gene id: 237561:CAALFM_C502050WA
uniprot id: A0A1D8PNB4
names: Similarity
messages: Belongs to the dopey family.

237561:CAALFM CR04570CA
gene id: 237561:CAALFM_CR04570CA
uniprot id: P39827
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Expressed at higher levels in cells growing as hyphae than in those growing as budding yeasts.
messages: Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.

237561:CAALFM C401500WA
gene id: 237561:CAALFM_C401500WA
uniprot id: Q5AML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

237561:CAALFM C400960WA
gene id: 237561:CAALFM_C400960WA
uniprot id: Q5AME8
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM C300430WA
gene id: 237561:CAALFM_C300430WA
uniprot id: Q5A7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EST3 family.
messages: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
messages: Component of the telomerase complex.
messages: Nucleus
messages: telomere

237561:CAALFM C406300CA
gene id: 237561:CAALFM_C406300CA
uniprot id: Q5A1B2
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment.
messages: cell wall

237561:CAALFM C304180WA
gene id: 237561:CAALFM_C304180WA
uniprot id: Q5ANN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

237561:CAALFM CR05610CA
gene id: 237561:CAALFM_CR05610CA
uniprot id: Q59M56
names: Disruption Phenotype
names: Function
messages: Causes defects in hyphal development, reduced resistance to osmotic and oxidative stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.
messages: Required for stress adaptation, morphogenesis and virulence.

237561:CAALFM C601720CA
gene id: 237561:CAALFM_C601720CA
uniprot id: Q5A4M8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUR7 family.
messages: Cell membrane
messages: Induced by fluconazole and down-regulated in absence of GOA1.
messages: Involved in cell wall, plasma membrane, and cytoskeletal organization. Plays a role in endocytosis and hyphal morphogenesis. Required to restrict septin proteins to the bud neck and prevents intracellular growth of cell wall. Contributes to secretion, biofilm formation, and macrophage killing. Essential for resistance to stressful conditions and for invasive growth and virulence.
messages: Leads to defective tolerance to cell wall stress and antifungal agents targeting cell wall components, defective plasma membrane structure, defective endocytosis, impaired lipase secretion, SAP2 over-production, increased adherence, aberrant biofilm formation, defective macrophage killing, and decreased virulence in a mouse infection model.

237561:CAALFM CR04190WA
gene id: 237561:CAALFM_CR04190WA
uniprot id: Q5A6P9
names: Similarity
messages: Belongs to the CAP family.

237561:CAALFM CR02160WA
gene id: 237561:CAALFM_CR02160WA
uniprot id: Q5A950
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Membrane
messages: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.

237561:CAALFM C206520CA
gene id: 237561:CAALFM_C206520CA
uniprot id: Q59Q36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM CR10670WA
gene id: 237561:CAALFM_CR10670WA
uniprot id: Q5ACI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

237561:CAALFM C108560WA
gene id: 237561:CAALFM_C108560WA
uniprot id: Q59QB7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

237561:CAALFM CR10250CA
gene id: 237561:CAALFM_CR10250CA
uniprot id: A0A1D8PU61
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

237561:CAALFM C103280WA
gene id: 237561:CAALFM_C103280WA
uniprot id: Q5AI30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

237561:CAALFM CR03790CA
gene id: 237561:CAALFM_CR03790CA
uniprot id: P0CY22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE1 family.
messages: Cell membrane
messages: Involved in cell wall 1,6-beta-glucan assembly possibly by the addition of linear side chains of 1,6-linked Glc units to a highly branched 1,6- and 1,3-linked glucan backbone.
messages: cell wall

237561:CAALFM C303730CA
gene id: 237561:CAALFM_C303730CA
uniprot id: Q59SS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

237561:CAALFM C502910CA
gene id: 237561:CAALFM_C502910CA
uniprot id: A0A1D8PNL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C600300CA
gene id: 237561:CAALFM_C600300CA
uniprot id: A0A1D8PPB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

237561:CAALFM C602680WA
gene id: 237561:CAALFM_C602680WA
uniprot id: A0A1D8PPZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C301730CA
gene id: 237561:CAALFM_C301730CA
uniprot id: Q5AJC0
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.
messages: Extracellular glycosidase which plays an important role in fungal pathogenesis. Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells. Plays a role of cell surface antigen in acute candidemia patients.
messages: Leads to increased susceptibility to cell wall-perturbing agents, defect in filamentation, reduction in adherence to mammalian cells in an in vitro adhesion assay, and a prolongation of survival in an immunocompetent mouse model of disseminated candidiasis.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Up-regulated by heat stress, calcineurin, micafungin, and fluconazole. Protein abundance is increased at pH 4 compared to pH 7. Expression is also regulated by RCH1.
messages: cell wall

237561:CAALFM CR00240WA
gene id: 237561:CAALFM_CR00240WA
uniprot id: A0A1D8PRP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

237561:CAALFM CR02050CA
gene id: 237561:CAALFM_CR02050CA
uniprot id: Q5A960
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Interacts with BRG1.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation of filamentous growth and virulence. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency.

237561:CAALFM C503790WA
gene id: 237561:CAALFM_C503790WA
uniprot id: A0A1D8PNS0
names: Similarity
messages: Belongs to the guanylate kinase family.

237561:CAALFM C209070CA
gene id: 237561:CAALFM_C209070CA
uniprot id: A0A1D8PIC6
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

237561:CAALFM CR02360WA
gene id: 237561:CAALFM_CR02360WA
uniprot id: A0A1D8PS79
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

237561:CAALFM C110040WA
gene id: 237561:CAALFM_C110040WA
uniprot id: A0A1D8PER8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: May function both as a monomer and a homodimer.

237561:CAALFM C401920WA
gene id: 237561:CAALFM_C401920WA
uniprot id: A0A1D8PLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

237561:CAALFM C504520WA
gene id: 237561:CAALFM_C504520WA
uniprot id: A0A1D8PNZ9
names: Similarity
messages: Belongs to the TIP41 family.

237561:CAALFM C108880WA
gene id: 237561:CAALFM_C108880WA
uniprot id: A0A1D8PEF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

237561:CAALFM CR04160CA
gene id: 237561:CAALFM_CR04160CA
uniprot id: Q5A6Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

237561:CAALFM C603640WA
gene id: 237561:CAALFM_C603640WA
uniprot id: A0A1D8PQ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: May be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion
messages: nucleolus

237561:CAALFM C500830CA
gene id: 237561:CAALFM_C500830CA
uniprot id: Q59X92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

237561:CAALFM C604280WA
gene id: 237561:CAALFM_C604280WA
uniprot id: A0A1D8PQD4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C504630WA
gene id: 237561:CAALFM_C504630WA
uniprot id: Q5AK73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
messages: centromere

237561:CAALFM C104830WA
gene id: 237561:CAALFM_C104830WA
uniprot id: A0A1D8PDE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

237561:CAALFM C107420CA
gene id: 237561:CAALFM_C107420CA
uniprot id: A0A1D8PE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-3 family.
messages: Membrane
messages: Peroxisome membrane

237561:CAALFM CR02520WA
gene id: 237561:CAALFM_CR02520WA
uniprot id: Q59LT9
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

237561:CAALFM C502840CA
gene id: 237561:CAALFM_C502840CA
uniprot id: Q5AG71
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Bud neck
messages: Leads to elongated cell phenotype.
messages: Phosphorylated throughout the cell cycle, except for the G1 phase.
messages: Protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of SWE1 and CDC28. Regulates pseudohypha formation, but is not required for septin ring organization or septum formation. Plays an essential role in virulence in a mouse model.

237561:CAALFM C208480WA
gene id: 237561:CAALFM_C208480WA
uniprot id: A0A1D8PI52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

237561:CAALFM C500230CA
gene id: 237561:CAALFM_C500230CA
uniprot id: Q5A4X4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

237561:CAALFM C502400WA
gene id: 237561:CAALFM_C502400WA
uniprot id: Q5AGD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
messages: Nucleus

237561:CAALFM C405150WA
gene id: 237561:CAALFM_C405150WA
uniprot id: Q59MN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.
messages: Vacuole membrane

237561:CAALFM C502970WA
gene id: 237561:CAALFM_C502970WA
uniprot id: A0A1D8PNK0
names: Similarity
messages: Belongs to the peptidase S9B family.

237561:CAALFM CR09380WA
gene id: 237561:CAALFM_CR09380WA
uniprot id: A0A1D8PTY6
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM CR08120CA
gene id: 237561:CAALFM_CR08120CA
uniprot id: A0A1D8PTQ2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

237561:CAALFM C100580WA
gene id: 237561:CAALFM_C100580WA
uniprot id: Q5ABC2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C505020CA
gene id: 237561:CAALFM_C505020CA
uniprot id: Q5AK26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR05300CA
gene id: 237561:CAALFM_CR05300CA
uniprot id: Q59KJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane

237561:CAALFM C701960WA
gene id: 237561:CAALFM_C701960WA
uniprot id: Q5AH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

237561:CAALFM C302700WA
gene id: 237561:CAALFM_C302700WA
uniprot id: A0A1D8PJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

237561:CAALFM C209770CA
gene id: 237561:CAALFM_C209770CA
uniprot id: A0A1D8PIH6
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

237561:CAALFM CR08430WA
gene id: 237561:CAALFM_CR08430WA
uniprot id: Q5A352
names: Similarity
messages: Belongs to the VAC14 family.

237561:CAALFM C701480WA
gene id: 237561:CAALFM_C701480WA
uniprot id: Q5AGV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: The DHHC domain is required for palmitoyltransferase activity.

237561:CAALFM CR00510CA
gene id: 237561:CAALFM_CR00510CA
uniprot id: A0A1D8PRQ1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

237561:CAALFM C104200CA
gene id: 237561:CAALFM_C104200CA
uniprot id: A0A1D8PD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

237561:CAALFM C602610CA
gene id: 237561:CAALFM_C602610CA
uniprot id: Q8X1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC37 family.
messages: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
messages: Cytoplasm
messages: Forms a complex with Hsp90. Interacts with a number of kinases such as crk1.

237561:CAALFM C105600WA
gene id: 237561:CAALFM_C105600WA
uniprot id: A0A1D8PDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

237561:CAALFM C702870CA
gene id: 237561:CAALFM_C702870CA
uniprot id: A0A1D8PR78
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C300810CA
gene id: 237561:CAALFM_C300810CA
uniprot id: A0A1D8PJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

237561:CAALFM CR03490WA
gene id: 237561:CAALFM_CR03490WA
uniprot id: Q59ZZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO5 family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Mitochondrion
messages: Monomer.
messages: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).

237561:CAALFM C500250CA
gene id: 237561:CAALFM_C500250CA
uniprot id: Q5A4X6
names: Similarity
messages: Belongs to the SRR1 family.

237561:CAALFM C501140CA
gene id: 237561:CAALFM_C501140CA
uniprot id: A0A1D8PN34
names: Function
names: Similarity
messages: Belongs to the CCM1 family.
messages: RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.

237561:CAALFM C100560WA
gene id: 237561:CAALFM_C100560WA
uniprot id: Q5ABB8
names: Similarity
messages: Belongs to the TTC4 family.

237561:CAALFM C404310WA
gene id: 237561:CAALFM_C404310WA
uniprot id: Q59PA0
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

237561:CAALFM C206950CA
gene id: 237561:CAALFM_C206950CA
uniprot id: Q59Z51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C209220WA
gene id: 237561:CAALFM_C209220WA
uniprot id: Q59X49
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DDR48 family.
messages: Cell surface protein involved in the ability to sense and respond to changes in the host environment. Required for stress response and confers partial antifungal drug resistance. Contributes to the DNA damage response. Required for the flocculation response stimulated by 3-aminotriazole-induced amino acid starvation.
messages: Expression is induced during filamentation, biofilm formation, after UV exposure, as well as by benomyl, caspofungin, and ketoconazole. Also enriched in azole-resistant strains and in stationary phase. Expression is repressed by SKO1, HOG1, RFX2, farnesol, and in alkaline conditions. Expression is also controlled by the filamentous growth regulators CPH1, CPH2, and EFG1.
messages: cell wall
messages: leads to reduced flocculation stimulated by 3-aminotriazole-induced amino acid starvation.

237561:CAALFM C302880WA
gene id: 237561:CAALFM_C302880WA
uniprot id: Q5AEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

237561:CAALFM C500070WA
gene id: 237561:CAALFM_C500070WA
uniprot id: G1UB61
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Causes greater curvature of cells growing in a filamentous manner and morphological defects in suspensor cells and chlamydospores. Leads to reduced tissue penetration and non-invasive fungal masses in mice infected kidneys. Leads also to hypersusceptibility to caspofungin.
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SEP7. The purified septin complex appeared to have a stoichiometry of 2 CDC3, 1 to 2 CDC10, 1 CDC11, 2 CDC12, and 1 or none SEP7 subunit. Interacts with HSL1.
messages: Hyphal induction causes immediate phosphorylation at Ser-395 by GIN4 and at Ser-394 by CDC28-CCN1. GIN4 phosphorylation at Ser-395 primes CDC11 for further phosphorylation by CDC28-CCN1. CDC28-HGC1 then maintains CDC11 phosphorylation throughout hyphal growth. Ser-4 is also phosphorylated in yeast cells but not hyphal cells.
messages: Met-1 is acetylated.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinase GIN4. Septins are also involved in cell morphogenesis, chlamydospores morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization, and spore wall formation. CDC11 is required for the correct localization of SEC3 at bud tips and bud necks. Plays a key role in invasive growth and virulence.

237561:CAALFM C600860WA
gene id: 237561:CAALFM_C600860WA
uniprot id: A0A1D8PPH4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

237561:CAALFM C112030WA
gene id: 237561:CAALFM_C112030WA
uniprot id: Q5A3K7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM C306890WA
gene id: 237561:CAALFM_C306890WA
uniprot id: Q5ADM9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Disruption of both alleles leads to letality. Disruption of only one allele impairs filamentation and leads to an altered cell wall composition with reduced amounts of beta-1,6-glucan and shows reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE).
messages: Endoplasmic reticulum membrane
messages: PMT1 and PMT2 form a functional heterodimer.
messages: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence.
messages: Transcribed in the yeast form, but expression is increased two to threefold during hyphal induction. Also induced during cell wall regeneration. Up-regulated more than twofold when PMT1 expression is impaired. MSB2 functions not only to secure basal levels of the PMT2 transcripts but is needed also for up-regulation of both transcripts upon PMT1 inhibition.

237561:CAALFM C300770CA
gene id: 237561:CAALFM_C300770CA
uniprot id: A0A1D8PJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C303510CA
gene id: 237561:CAALFM_C303510CA
uniprot id: A0A1D8PJP3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504060CA
gene id: 237561:CAALFM_C504060CA
uniprot id: Q59LR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity).

237561:CAALFM C204120CA
gene id: 237561:CAALFM_C204120CA
uniprot id: Q5AHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

237561:CAALFM C209740WA
gene id: 237561:CAALFM_C209740WA
uniprot id: Q59YF0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.
messages: Leads to defects in secretion of degradative enzymes and defects in hyphal extension. Leads also to the Spitzenkoerper dissipation and accumulation of secretory vesicles.
messages: Membrane

237561:CAALFM C109450CA
gene id: 237561:CAALFM_C109450CA
uniprot id: A0A1D8PEL3
names: Subcellular Location Annotation
messages: nuclear pore complex

237561:CAALFM C300520WA
gene id: 237561:CAALFM_C300520WA
uniprot id: Q5A7Q5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C108340CA
gene id: 237561:CAALFM_C108340CA
uniprot id: Q5A748
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Prevacuolar compartment membrane
messages: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

237561:CAALFM CR03720WA
gene id: 237561:CAALFM_CR03720WA
uniprot id: Q5A017
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

237561:CAALFM CR10390WA
gene id: 237561:CAALFM_CR10390WA
uniprot id: A0A1D8PU84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

237561:CAALFM C301000WA
gene id: 237561:CAALFM_C301000WA
uniprot id: A0A1D8PJ43
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C102520WA
gene id: 237561:CAALFM_C102520WA
uniprot id: Q5AIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

237561:CAALFM C305810CA
gene id: 237561:CAALFM_C305810CA
uniprot id: A0A1D8PKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

237561:CAALFM C604260CA
gene id: 237561:CAALFM_C604260CA
uniprot id: A0A1D8PQD9
names: Similarity
messages: Belongs to the CCDC25 family.

237561:CAALFM C701470CA
gene id: 237561:CAALFM_C701470CA
uniprot id: A0A1D8PQW1
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C114300CA
gene id: 237561:CAALFM_C114300CA
uniprot id: A0A1D8PFW9
names: Similarity
messages: Belongs to the patched family.

237561:CAALFM C203440WA
gene id: 237561:CAALFM_C203440WA
uniprot id: Q5AHC0
names: Subcellular Location Annotation
messages: Cell membrane

237561:CAALFM C500460CA
gene id: 237561:CAALFM_C500460CA
uniprot id: Q5A503
names: Similarity
messages: Belongs to the multicopper oxidase family.

237561:CAALFM C111000CA
gene id: 237561:CAALFM_C111000CA
uniprot id: Q59WI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

237561:CAALFM CR03350CA
gene id: 237561:CAALFM_CR03350CA
uniprot id: Q59UH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial mRNA stabilization factor.

237561:CAALFM C302210CA
gene id: 237561:CAALFM_C302210CA
uniprot id: A0A1D8PJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

237561:CAALFM C304430WA
gene id: 237561:CAALFM_C304430WA
uniprot id: A0A1D8PJX3
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

237561:CAALFM C406550CA
gene id: 237561:CAALFM_C406550CA
uniprot id: Q5A1E0
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: Expression is down-regulated in absence of GOA1.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C500870CA
gene id: 237561:CAALFM_C500870CA
uniprot id: A0A1D8PN14
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876).
messages: Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT3 (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).
messages: Triple deletion of GIT2, GIT3 and GIT4 impairs the uptake of glycerophosphocholine (GroPCho) and reduces virulence in a mouse model of blood stream infection (PubMed:24114876).

237561:CAALFM CR05640CA
gene id: 237561:CAALFM_CR05640CA
uniprot id: Q59PR4
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C307460WA
gene id: 237561:CAALFM_C307460WA
uniprot id: Q5ADU9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

237561:CAALFM C207090CA
gene id: 237561:CAALFM_C207090CA
uniprot id: A0A1D8PHT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

237561:CAALFM C500690CA
gene id: 237561:CAALFM_C500690CA
uniprot id: A0A1D8PN00
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C400130WA
gene id: 237561:CAALFM_C400130WA
uniprot id: Q59UT4
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: Cell membrane
messages: GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454, PubMed:27617569). Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454, PubMed:27617569). The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454).
messages: Induced by iron starvation, hypoxia, amphotericin B, and during hyphal growth. Repressed by ketoconazole and caspofungin. Regulated by BCR1, HOG1, SFU1, TUP1, and UPC2.
messages: Interacts with PGA7.
messages: Leads to defects in hemin and hemoglobin utilization as sole source of iron.
messages: Mannosylated.
messages: The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (PubMed:12633989, PubMed:22145027, PubMed:25275454). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity).
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C106680WA
gene id: 237561:CAALFM_C106680WA
uniprot id: A0A1D8PDV7
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the PI3/PI4-kinase family.
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I composed of at least VPS15, VPS30, VPS34, and of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38 (By similarity). Interacts with VMNA7 (PubMed:15861817).
messages: Endosome membrane
messages: Expression is increased up to 12-fold during exponential growth, followed by a decline upon entry into stationary phase.
messages: Leads to defective acidification of the vacuoles and a lack of growth at pH 8.0 (PubMed:15861817). Vacuoles are considerably enlarged and electron-transparent (PubMed:11223944). Shows aberrant patch-like accumulation of vesicles, which are localized in the periplasm close to the plasma membrane (PubMed:11223944). Shows a staining of punctuate structures, possibly multivesicular bodies (MVB), that are scattered all over the cell, the result of a late block in endocytic vesicle transport (PubMed:11223944). Results in significantly lower carboxypeptidase Y activity (PubMed:11223944). Causes disturbance of normal nuclear migration (PubMed:11223944). Leads also to avirulence in mice (PubMed:15632428).
messages: Multifunctional phosphatidylinositol 3-kinase involved in acidification of vacuoles, pH-dependent cell growth, and autophagocytosis (PubMed:15861817, PubMed:15632428). Plays an important role in protein transport and virulence (PubMed:11223944, PubMed:15632428). Component of the autophagy-specific VPS34 PI3-kinase complex I essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (By similarity). Finally, it might also be involved in ethanol tolerance and cell wall integrity (By similarity).
messages: trans-Golgi network membrane

237561:CAALFM CR09950CA
gene id: 237561:CAALFM_CR09950CA
uniprot id: A0A1D8PU46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

237561:CAALFM C302500WA
gene id: 237561:CAALFM_C302500WA
uniprot id: Q5AEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex, at least composed of mtHsp70 (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18.
messages: Mitochondrion inner membrane

237561:CAALFM C114450CA
gene id: 237561:CAALFM_C114450CA
uniprot id: A0A1D8PFY5
names: Similarity
messages: Belongs to the peptidase M24B family.

237561:CAALFM C109220WA
gene id: 237561:CAALFM_C109220WA
uniprot id: Q5API4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C110090CA
gene id: 237561:CAALFM_C110090CA
uniprot id: Q5AP87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM21 family.
messages: Involved in mitochondrial migration along actin filaments.
messages: actin patch

237561:CAALFM C201920CA
gene id: 237561:CAALFM_C201920CA
uniprot id: Q5AM72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Membrane
messages: Probable lipid hydrolase.

237561:CAALFM C701850CA
gene id: 237561:CAALFM_C701850CA
uniprot id: A0A1D8PQZ0
names: Similarity
messages: Belongs to the WD repeat coronin family.

237561:CAALFM C202950WA
gene id: 237561:CAALFM_C202950WA
uniprot id: A0A1D8PGR0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C201110CA
gene id: 237561:CAALFM_C201110CA
uniprot id: Q9HEW1
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).

237561:CAALFM C700940WA
gene id: 237561:CAALFM_C700940WA
uniprot id: Q5AFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
messages: trans-Golgi network membrane

237561:CAALFM C505310WA
gene id: 237561:CAALFM_C505310WA
uniprot id: Q5AJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

237561:CAALFM C702030WA
gene id: 237561:CAALFM_C702030WA
uniprot id: P46598
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

237561:CAALFM C701880CA
gene id: 237561:CAALFM_C701880CA
uniprot id: Q5AH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C109140CA
gene id: 237561:CAALFM_C109140CA
uniprot id: Q5AQ36
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHO1 family.
messages: Cell membrane
messages: Forms homooligomers.
messages: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis.
messages: Repressed by caspofungin.

237561:CAALFM C202710CA
gene id: 237561:CAALFM_C202710CA
uniprot id: Q5A0H6
names: Similarity
messages: Belongs to the RRP7 family.

237561:CAALFM C104530CA
gene id: 237561:CAALFM_C104530CA
uniprot id: A0A1D8PDB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

237561:CAALFM CR01340WA
gene id: 237561:CAALFM_CR01340WA
uniprot id: Q5A9E8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR07600WA
gene id: 237561:CAALFM_CR07600WA
uniprot id: A0A1D8PTJ0
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C505290CA
gene id: 237561:CAALFM_C505290CA
uniprot id: Q5AJZ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

237561:CAALFM C402830CA
gene id: 237561:CAALFM_C402830CA
uniprot id: Q5AF95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C110670CA
gene id: 237561:CAALFM_C110670CA
uniprot id: A0A1D8PEX3
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C102390WA
gene id: 237561:CAALFM_C102390WA
uniprot id: A0A1D8PCQ2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C109050WA
gene id: 237561:CAALFM_C109050WA
uniprot id: Q5AQ47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
messages: Nucleus

237561:CAALFM C600830CA
gene id: 237561:CAALFM_C600830CA
uniprot id: A0A1D8PPG4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is regulated upon white-opaque switch (PubMed:12397174). Expression is repressed by HAP43 (PubMed:21592964).
messages: Probable permease for arginine and lysine.

237561:CAALFM C113610CA
gene id: 237561:CAALFM_C113610CA
uniprot id: Q5AKY0
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

237561:CAALFM C103220CA
gene id: 237561:CAALFM_C103220CA
uniprot id: O42766
names: Similarity
messages: Belongs to the 14-3-3 family.

237561:CAALFM C502630CA
gene id: 237561:CAALFM_C502630CA
uniprot id: Q5AGA0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Expression is negatively regulated by RIM101. Expression is also increased in absence of SUR7, as well as CHK1 and NIK1.
messages: Golgi apparatus membrane
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).

237561:CAALFM C503640WA
gene id: 237561:CAALFM_C503640WA
uniprot id: P0CU37
uniprot id: Q59NX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diphthine synthase family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

237561:CAALFM C601890CA
gene id: 237561:CAALFM_C601890CA
uniprot id: Q5A4P9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C402140CA
gene id: 237561:CAALFM_C402140CA
uniprot id: A0A1D8PLH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

237561:CAALFM C604060WA
gene id: 237561:CAALFM_C604060WA
uniprot id: A0A1D8PQB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

237561:CAALFM CR07000CA
gene id: 237561:CAALFM_CR07000CA
uniprot id: A0A1D8PTD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

237561:CAALFM C107870CA
gene id: 237561:CAALFM_C107870CA
uniprot id: A0A1D8PE53
names: Similarity
messages: Belongs to the KNR4/SMI1 family.

237561:CAALFM C206350CA
gene id: 237561:CAALFM_C206350CA
uniprot id: A0A1D8PHL9
names: Similarity
messages: Belongs to the 4HPPD family.

237561:CAALFM CR03110WA
gene id: 237561:CAALFM_CR03110WA
uniprot id: A0A1D8PSE8
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

237561:CAALFM C305620WA
gene id: 237561:CAALFM_C305620WA
uniprot id: A0A1D8PKD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C603030WA
gene id: 237561:CAALFM_C603030WA
uniprot id: P43094
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae and true hyphae. Induced during host infection.
messages: Inhibited by pepstatin A analogs.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C209080CA
gene id: 237561:CAALFM_C209080CA
uniprot id: A0A1D8PIC3
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM CR00370WA
gene id: 237561:CAALFM_CR00370WA
uniprot id: A0A1D8PRP1
names: Similarity
messages: Belongs to the cullin family.

237561:CAALFM C306580WA
gene id: 237561:CAALFM_C306580WA
uniprot id: A0A1D8PKH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C305000WA
gene id: 237561:CAALFM_C305000WA
uniprot id: Q5AND4
names: Similarity
messages: Belongs to the Rho GDI family.

237561:CAALFM C306410CA
gene id: 237561:CAALFM_C306410CA
uniprot id: A0A1D8PKN1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C701340WA
gene id: 237561:CAALFM_C701340WA
uniprot id: A0A1D8PQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

237561:CAALFM C701920WA
gene id: 237561:CAALFM_C701920WA
uniprot id: Q5AH09
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C403790WA
gene id: 237561:CAALFM_C403790WA
uniprot id: A0A1D8PLW8
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

237561:CAALFM C400530CA
gene id: 237561:CAALFM_C400530CA
uniprot id: Q59SI3
names: Similarity
messages: Belongs to the SurE nucleotidase family.

237561:CAALFM C300560CA
gene id: 237561:CAALFM_C300560CA
uniprot id: Q5A7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

237561:CAALFM CR00870CA
gene id: 237561:CAALFM_CR00870CA
uniprot id: Q5A861
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.

237561:CAALFM C303060WA
gene id: 237561:CAALFM_C303060WA
uniprot id: Q5AEG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

237561:CAALFM C304130WA
gene id: 237561:CAALFM_C304130WA
uniprot id: Q5ANP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

237561:CAALFM C107600WA
gene id: 237561:CAALFM_C107600WA
uniprot id: Q59PV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Mitochondrion inner membrane

237561:CAALFM CR03610CA
gene id: 237561:CAALFM_CR03610CA
uniprot id: A0A1D8PSJ6
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C505360CA
gene id: 237561:CAALFM_C505360CA
uniprot id: Q5AJY9
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

237561:CAALFM C110450WA
gene id: 237561:CAALFM_C110450WA
uniprot id: Q59NC4
names: Similarity
messages: Belongs to the threonine aldolase family.

237561:CAALFM C500080CA
gene id: 237561:CAALFM_C500080CA
uniprot id: A0A1D8PMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

237561:CAALFM C109600CA
gene id: 237561:CAALFM_C109600CA
uniprot id: Q9P4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C101370CA
gene id: 237561:CAALFM_C101370CA
uniprot id: A0A1D8PCG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS21B is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits and has a physiological role leading to 18S rRNA stability (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C600340CA
gene id: 237561:CAALFM_C600340CA
uniprot id: Q59RK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
messages: Mitochondrion matrix

237561:CAALFM CR04140WA
gene id: 237561:CAALFM_CR04140WA
uniprot id: Q5A6Q6
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

237561:CAALFM C206490WA
gene id: 237561:CAALFM_C206490WA
uniprot id: Q59Q38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).

237561:CAALFM C103770WA
gene id: 237561:CAALFM_C103770WA
uniprot id: Q59VR1
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Expression is induced by cell wall damage caused by caspofungin, and by osmotic stress through the HOG1 pathway. Expression is positively regulated by MNL1.
messages: Leads to caspofungin hypersensitivity and increases filamentation.
messages: Nucleus
messages: Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Controls also the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress.
messages: Undergoes HOG1-dependent phosphorylation after osmotic stress.

237561:CAALFM C207220WA
gene id: 237561:CAALFM_C207220WA
uniprot id: A0A1D8PHU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Component of the 20S proteasome chaperone.
messages: Involved in 20S proteasome assembly.

237561:CAALFM C110220CA
gene id: 237561:CAALFM_C110220CA
uniprot id: Q5AP71
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM CR05720WA
gene id: 237561:CAALFM_CR05720WA
uniprot id: Q92410
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Abolishes hyphal formation and impairs biofilm formation (PubMed:28743811). Sensitive to thermal stress (PubMed:28743811).
messages: Belongs to the glycosyltransferase 20 family.
messages: By heat shock.
messages: Inhibited by validoxylamine A, a non-reactive trehalose analog.
messages: Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.

237561:CAALFM C402160CA
gene id: 237561:CAALFM_C402160CA
uniprot id: A0A1D8PLH5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

237561:CAALFM C604520WA
gene id: 237561:CAALFM_C604520WA
uniprot id: Q59RI1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C101690CA
gene id: 237561:CAALFM_C101690CA
uniprot id: Q5A8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

237561:CAALFM C405750CA
gene id: 237561:CAALFM_C405750CA
uniprot id: Q5A449
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C112410CA
gene id: 237561:CAALFM_C112410CA
uniprot id: Q5A3P6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
messages: Nucleus
messages: Sensitive to cell wall-damaging agents SDS and Congo red.
messages: Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
messages: The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.
messages: cell cortex

237561:CAALFM C207730WA
gene id: 237561:CAALFM_C207730WA
uniprot id: Q5A2J7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family.
messages: Expression is down-regulated in response to alkaline pH when CRZ1 or RIM101 are deleted.
messages: Leads to hypersensitivity to oxidative stress, increased sensitivity to killing by macrophages, reduced ability to invade epithelium cells, and attenuated virulence in a mouse model. Shows defects in hyphal maintenance, hyphal growth and flocculation. Prevents the localization of the Spitzenkoerper to hyphal tips. Enhances mitochondrial depolarization and apoptosis.
messages: Vacuolar calcium channel involved in the release of calcium ions from the vacuole in response to hyperosmotic or alkaline stress. Required for activation of CAP1-related transcription of oxidative stress response (OSR) genes, but also for maintaining the stability of both the mitochondria and the vacuole in a potassium- and calcium-dependent manner. Contributes to pathogenicity. Plays a key role in hyphal polarized growth and re-orientation to host-signals through its contribution to the localization of the Spitzenkoerper to the hyphal tips.
messages: Vacuole membrane

237561:CAALFM CR04210CA
gene id: 237561:CAALFM_CR04210CA
uniprot id: Q5A6P6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Expression is repressed by caspofungin and during chlamydospore formation. Also regulated during white-opaque switch, and by NRG1, TUP1 and HAP43.
messages: Leads to defects in biofilm architecture.
messages: MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.

237561:CAALFM C110340WA
gene id: 237561:CAALFM_C110340WA
uniprot id: Q5AP58
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C702600CA
gene id: 237561:CAALFM_C702600CA
uniprot id: A0A1D8PR73
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C703870WA
gene id: 237561:CAALFM_C703870WA
uniprot id: O74201
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
messages: Cytoplasm
messages: Nucleus
messages: Up-regulated by UV radiation, heat shock, osmotic stress and nitrogen starvation.

237561:CAALFM C105120WA
gene id: 237561:CAALFM_C105120WA
uniprot id: Q59LX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).
messages: Vacuole membrane

237561:CAALFM C304320WA
gene id: 237561:CAALFM_C304320WA
uniprot id: A0A1D8PK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM C109660WA
gene id: 237561:CAALFM_C109660WA
uniprot id: A0A1D8PEM3
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C402990CA
gene id: 237561:CAALFM_C402990CA
uniprot id: Q5AFB4
names: Similarity
messages: Belongs to the GST superfamily.

237561:CAALFM C500650CA
gene id: 237561:CAALFM_C500650CA
uniprot id: Q92209
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Homodimer.

237561:CAALFM C110970WA
gene id: 237561:CAALFM_C110970WA
uniprot id: A0A1D8PEZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

237561:CAALFM C203470CA
gene id: 237561:CAALFM_C203470CA
uniprot id: A0A1D8PH08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

237561:CAALFM CR00850CA
gene id: 237561:CAALFM_CR00850CA
uniprot id: A0A1D8PRT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

237561:CAALFM C204150CA
gene id: 237561:CAALFM_C204150CA
uniprot id: A0A1D8PH17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: Vacuole membrane

237561:CAALFM C306110CA
gene id: 237561:CAALFM_C306110CA
uniprot id: A0A1D8PKE0
names: Similarity
messages: Belongs to the NAD kinase family.

237561:CAALFM C112390CA
gene id: 237561:CAALFM_C112390CA
uniprot id: A0A1D8PFG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C105710CA
gene id: 237561:CAALFM_C105710CA
uniprot id: A0A1D8PDL9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00190WA
gene id: 237561:CAALFM_CR00190WA
uniprot id: A0A1D8PRM0
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

237561:CAALFM C201610CA
gene id: 237561:CAALFM_C201610CA
uniprot id: Q5ALV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C305870CA
gene id: 237561:CAALFM_C305870CA
uniprot id: A0A1D8PKC4
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C603170CA
gene id: 237561:CAALFM_C603170CA
uniprot id: Q5ABU7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Constitutive, high-level transcription is commonly observed in laboratory and clinical strains of Candida albicans that are resistant to the antifungal drug fluconazole. Multiple cis-acting sequences within the promoter mediate its activation. One, a benomyl response element (BRE), is situated at position -296 to -260. It is required for benomyl-dependent MDR1 up-regulation and is also necessary for constitutive high expression of MDR1. A second element, termed H(2)O(2) response element (HRE), is situated at position -561 to -520. The HRE is required for H(2)O(2)-dependent MDR1 up-regulation, but dispensable for constitutive high expression. Two potential binding sites (TTAG/CTAA) for the transcription factor CAP1 lie within the HRE. Expression is induced by fluconazole, rifampicin, methotrexate, diethylmaleate, diamide, 4-nitroquinoline-N-oxide, benomyl, o-phenanthroline (OP), hydrogen peroxide, methyl methanesulfonate, and sulfometuron methyl. Expression is down-regulated by tetrandrine and levofloxacin derivatives. Transcription is positively regulated by ADA2, CAP1, MRR1, UPC2, and TAC1; and negatively regulated by REP1. Transcription is also regulated by the general transcription factor MCM1. MCM1 is dispensable for up-regulation by H(2)O(2) but is required for full induction by benomyl.
messages: Leads to enhanced susceptibility against fluconazole, methotrexate, 4-nitroquinoline-N-oxide, and cycloheximide.
messages: Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A.
messages: The central cytoplasmic loop (residues 295 to 350) is critical for the function, but unlike other homologous proteins, has no apparent role in imparting substrate specificity or in the recruitment of the transporter protein.
messages: The overexpression of MDR1 is a frequent cause of resistance to the widely used antimycotic agent fluconazole and other toxic compounds in the pathogenic yeast Candida albicans.

237561:CAALFM C104750WA
gene id: 237561:CAALFM_C104750WA
uniprot id: A0A1D8PDC5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C700060CA
gene id: 237561:CAALFM_C700060CA
uniprot id: A0A1D8PQH7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

237561:CAALFM CR09830WA
gene id: 237561:CAALFM_CR09830WA
uniprot id: A0A1D8PU23
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C601700WA
gene id: 237561:CAALFM_C601700WA
uniprot id: A0A1D8PPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C209640WA
gene id: 237561:CAALFM_C209640WA
uniprot id: P34948
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
messages: Monomer.

237561:CAALFM C107620CA
gene id: 237561:CAALFM_C107620CA
uniprot id: Q59PW0
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIR protein family.
messages: Expression is induced by host macrophages.
messages: Leads to increased chitin content in the cell wall, hyperfilamentation, and resistance to sodium dodecyl sulfate, hydrogen peroxide, and sodium chloride. Shows also an increased virulence in a mouse model.
messages: O-glycosylated. Extensively O-mannosylated.
messages: Probable structural component of the cell wall involved in cell wall integrity and virulence.
messages: cell wall

237561:CAALFM C400480WA
gene id: 237561:CAALFM_C400480WA
uniprot id: Q59UP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM C203000CA
gene id: 237561:CAALFM_C203000CA
uniprot id: A0A1D8PGR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C203060WA
gene id: 237561:CAALFM_C203060WA
uniprot id: Q5A0L8
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C102820WA
gene id: 237561:CAALFM_C102820WA
uniprot id: A0A1D8PCV7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

237561:CAALFM C300540CA
gene id: 237561:CAALFM_C300540CA
uniprot id: Q5A7Q7
names: Similarity
messages: Belongs to the IST1 family.

237561:CAALFM C110430WA
gene id: 237561:CAALFM_C110430WA
uniprot id: A0A1D8PEV2
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

237561:CAALFM C106130CA
gene id: 237561:CAALFM_C106130CA
uniprot id: A0A1D8PDR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

237561:CAALFM C302490CA
gene id: 237561:CAALFM_C302490CA
uniprot id: A0A1D8PJG4
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C502300CA
gene id: 237561:CAALFM_C502300CA
uniprot id: A0A1D8PND9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

237561:CAALFM C203600WA
gene id: 237561:CAALFM_C203600WA
uniprot id: Q5AHD6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT family.
messages: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan (By similarity). Plays a role in the ability to produce hyphae in the presence of three bacterial species.
messages: Leads to a hypo-filamentous phenotype.
messages: Membrane

237561:CAALFM C602780CA
gene id: 237561:CAALFM_C602780CA
uniprot id: A0A1D8PPZ7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

237561:CAALFM C600420WA
gene id: 237561:CAALFM_C600420WA
uniprot id: A0A1D8PPC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

237561:CAALFM C107690CA
gene id: 237561:CAALFM_C107690CA
uniprot id: A0A1D8PE78
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

237561:CAALFM C401000CA
gene id: 237561:CAALFM_C401000CA
uniprot id: Q5AMF7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA37 family.
messages: Cell membrane
messages: Induced by HAP43.
messages: Predicted GPI-anchored protein which may have a role during host infection.
messages: Secreted

237561:CAALFM CR02990CA
gene id: 237561:CAALFM_CR02990CA
uniprot id: Q5A1Y2
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

237561:CAALFM CR09020CA
gene id: 237561:CAALFM_CR09020CA
uniprot id: A0A1D8PTV3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR07910CA
gene id: 237561:CAALFM_CR07910CA
uniprot id: A0A1D8PTM3
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C703120WA
gene id: 237561:CAALFM_C703120WA
uniprot id: P48990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM54 family.
messages: Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C210660WA
gene id: 237561:CAALFM_C210660WA
uniprot id: Q5A5Q6
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RPD3C(L) complex.
messages: Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis.
messages: Expression is controlled by the transcription factor ACE2.
messages: Leads to defects in responding to some filament-inducing conditions and to reduced virulence.
messages: Nucleus
messages: The ASH1 mRNA is transported to the daughter cell before cytokinesis where translation produces the protein to block mating-type switching, as well as to the hyphal tips during filamentous growth.

237561:CAALFM C306500WA
gene id: 237561:CAALFM_C306500WA
uniprot id: A0A1D8PKJ3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

237561:CAALFM C202800WA
gene id: 237561:CAALFM_C202800WA
uniprot id: A0A1D8PGP8
names: Similarity
messages: Belongs to the YOS1 family.

237561:CAALFM C104380WA
gene id: 237561:CAALFM_C104380WA
uniprot id: Q59KY8
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Causes growth retardation and leads to significant reduction in virulence.
messages: Cytoplasm
messages: Interacts with MDS3.
messages: Serine/threonine protein phosphatase which is involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1 (By similarity). Plays a role during hyphal growth through the regulation of cell wall biogenesis, osmosensing and protein translation. Involved in virulence in a mouse systemic infection model.

237561:CAALFM C203380WA
gene id: 237561:CAALFM_C203380WA
uniprot id: Q5AHB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: actin patch

237561:CAALFM C401980CA
gene id: 237561:CAALFM_C401980CA
uniprot id: Q5AMQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

237561:CAALFM C111750WA
gene id: 237561:CAALFM_C111750WA
uniprot id: A0A1D8PF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C306300WA
gene id: 237561:CAALFM_C306300WA
uniprot id: Q5A309
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.

237561:CAALFM CR07660CA
gene id: 237561:CAALFM_CR07660CA
uniprot id: Q59N43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C304460WA
gene id: 237561:CAALFM_C304460WA
uniprot id: Q5ANK4
names: Similarity
messages: Belongs to the WD repeat mio family.

237561:CAALFM C206170CA
gene id: 237561:CAALFM_C206170CA
uniprot id: A0A1D8PHL8
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

237561:CAALFM C203550CA
gene id: 237561:CAALFM_C203550CA
uniprot id: A0A1D8PGW7
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C304940WA
gene id: 237561:CAALFM_C304940WA
uniprot id: Q5ANE0
names: Similarity
messages: Belongs to the UPP synthase family.

237561:CAALFM C305550CA
gene id: 237561:CAALFM_C305550CA
uniprot id: A0A1D8PKA6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

237561:CAALFM C102250WA
gene id: 237561:CAALFM_C102250WA
uniprot id: Q59VX6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201850WA
gene id: 237561:CAALFM_C201850WA
uniprot id: A0A1D8PGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

237561:CAALFM C100600WA
gene id: 237561:CAALFM_C100600WA
uniprot id: A0A1D8PCA6
names: Similarity
messages: Belongs to the APC1 family.

237561:CAALFM C102600WA
gene id: 237561:CAALFM_C102600WA
uniprot id: A0A1D8PCS7
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

237561:CAALFM C407110CA
gene id: 237561:CAALFM_C407110CA
uniprot id: Q5A0Z9
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

237561:CAALFM CR02280WA
gene id: 237561:CAALFM_CR02280WA
uniprot id: Q59V01
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probable cell surface protein involved in the process of adhesion and early events of invasion.
messages: Up-regulated when cells are growing in an adherent manner and upon milbemycins A3 oxim derivative (A3Ox) treatment. Expression is also regulated by CYR1, RIM101 and SSN6.

237561:CAALFM C406580WA
gene id: 237561:CAALFM_C406580WA
uniprot id: Q5A1E3
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Leads to auxotrophy for sulfur amino acids.
messages: Nucleus
messages: Repressed during biofilm formation.
messages: Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1.

237561:CAALFM C701160CA
gene id: 237561:CAALFM_C701160CA
uniprot id: A0A1D8PQU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM C307940WA
gene id: 237561:CAALFM_C307940WA
uniprot id: A0A1D8PKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Mitochondrion

237561:CAALFM C202150CA
gene id: 237561:CAALFM_C202150CA
uniprot id: Q5AM44
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C503550WA
gene id: 237561:CAALFM_C503550WA
uniprot id: A0A1D8PNP6
names: Subcellular Location Annotation
messages: nuclear pore complex

237561:CAALFM C204810WA
gene id: 237561:CAALFM_C204810WA
uniprot id: Q59LL5
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

237561:CAALFM C202190CA
gene id: 237561:CAALFM_C202190CA
uniprot id: Q5ALP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC family.
messages: Cytoplasm
messages: mRNA-binding protein which stimulates mRNA decapping.

237561:CAALFM C500880CA
gene id: 237561:CAALFM_C500880CA
uniprot id: Q5A1L6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876).
messages: Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT4 (PubMed:24114876). GIT3 acts as the major GroPCho permease (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).
messages: Triple deletion of GIT2, GIT3 and GIT4 impairs the uptake of glycerophosphocholine (GroPCho) and reduces virulence in a mouse model of blood stream infection (PubMed:24114876).

237561:CAALFM C500800CA
gene id: 237561:CAALFM_C500800CA
uniprot id: A0A1D8PN08
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

237561:CAALFM C305830WA
gene id: 237561:CAALFM_C305830WA
uniprot id: A0A1D8PKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

237561:CAALFM C505040WA
gene id: 237561:CAALFM_C505040WA
uniprot id: Q5AK24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).

237561:CAALFM C305840WA
gene id: 237561:CAALFM_C305840WA
uniprot id: A0A1D8PKB7
names: Similarity
messages: Belongs to the FMO family.

237561:CAALFM C205890CA
gene id: 237561:CAALFM_C205890CA
uniprot id: A0A1D8PHH7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

237561:CAALFM C207530CA
gene id: 237561:CAALFM_C207530CA
uniprot id: A0A1D8PI13
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

237561:CAALFM C503480CA
gene id: 237561:CAALFM_C503480CA
uniprot id: A0A1D8PNR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM CR05170CA
gene id: 237561:CAALFM_CR05170CA
uniprot id: Q59QN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C207030CA
gene id: 237561:CAALFM_C207030CA
uniprot id: A0A1D8PHU0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

237561:CAALFM C404920WA
gene id: 237561:CAALFM_C404920WA
uniprot id: Q5A6A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C700110WA
gene id: 237561:CAALFM_C700110WA
uniprot id: A0A1D8PQH5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

237561:CAALFM C500770CA
gene id: 237561:CAALFM_C500770CA
uniprot id: A0A1D8PN03
names: Function
names: Similarity
messages: Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
messages: In the C-terminal section; belongs to the DHPS family.
messages: In the N-terminal section; belongs to the DHNA family.
messages: In the central section; belongs to the HPPK family.

237561:CAALFM C110150WA
gene id: 237561:CAALFM_C110150WA
uniprot id: Q5AP80
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIT1/WOR1 family.
messages: Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
messages: Nucleus
messages: Only expressed in opaque cells, in which it forms a positive feedback loop since it binds its own DNA regulatory region and activates its own transcription leading to the accumulation of high levels of WOR1.

237561:CAALFM C110470WA
gene id: 237561:CAALFM_C110470WA
uniprot id: A0A1D8PEV9
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

237561:CAALFM C403840CA
gene id: 237561:CAALFM_C403840CA
uniprot id: A0A1D8PLY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

237561:CAALFM C404840CA
gene id: 237561:CAALFM_C404840CA
uniprot id: Q5A695
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR09680CA
gene id: 237561:CAALFM_CR09680CA
uniprot id: A0A1D8PU07
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

237561:CAALFM C404620CA
gene id: 237561:CAALFM_C404620CA
uniprot id: A0A1D8PM59
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C306790WA
gene id: 237561:CAALFM_C306790WA
uniprot id: Q5ADL8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate.
messages: Expression is induced in biofilm and repressed by alpha pheromone.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate.

237561:CAALFM C103910CA
gene id: 237561:CAALFM_C103910CA
uniprot id: A0A1D8PD40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

237561:CAALFM C100660CA
gene id: 237561:CAALFM_C100660CA
uniprot id: Q5ABD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM C501460WA
gene id: 237561:CAALFM_C501460WA
uniprot id: Q59NW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the timeless family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

237561:CAALFM C702010CA
gene id: 237561:CAALFM_C702010CA
uniprot id: Q5AH20
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C110320WA
gene id: 237561:CAALFM_C110320WA
uniprot id: A0A1D8PEU2
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

237561:CAALFM C206820CA
gene id: 237561:CAALFM_C206820CA
uniprot id: Q59Z65
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

237561:CAALFM C103300CA
gene id: 237561:CAALFM_C103300CA
uniprot id: A0A1D8PCY8
names: Similarity
messages: Belongs to the peptidase M16 family.

237561:CAALFM C210840WA
gene id: 237561:CAALFM_C210840WA
uniprot id: Q5A5N2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C502790CA
gene id: 237561:CAALFM_C502790CA
uniprot id: Q5AG77
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease that coordinates external nitrogen source response and morphogenesis (PubMed:12949183, PubMed:21764911, PubMed:28028545). Is capable of transporting several structurally unrelated amino acids such as leucine and phenylalanine, though with a lower capacity than the GAP2 and GAP6 permeases (PubMed:21764911). Has citrulline import activity (PubMed:12949183). GAP1 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911). Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Decreases two fold the citrulline uptake (PubMed:12949183). Leads to defective hyphal formation in solid hyphal-inducing media and exhibits less hyphal clumps when induced by N-acetylglucosamine (PubMed:12949183).
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is induced by N-acetylglucosamine (PubMed:12949183). Expression is also regulated by CPH1-mediated RAS1 signaling but is independent of EFG1 (PubMed:12949183). Induced during biofilm development (PubMed:21414038, PubMed:22265407, PubMed:23572557). Induced upon internalization by host macrophages (PubMed:15470236). Expression is down-regulated by growth in alkaline conditions (PubMed:15554973). Expression is also controlled by the nitrogen-dependent GATA-type transcriptional activator GAT1 (PubMed:14617156).

237561:CAALFM C205220CA
gene id: 237561:CAALFM_C205220CA
uniprot id: A0A1D8PHC5
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

237561:CAALFM C602460CA
gene id: 237561:CAALFM_C602460CA
uniprot id: Q5AC35
names: Similarity
messages: Belongs to the CBP3 family.

237561:CAALFM C202870WA
gene id: 237561:CAALFM_C202870WA
uniprot id: A0A1D8PGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

237561:CAALFM CR05740CA
gene id: 237561:CAALFM_CR05740CA
uniprot id: Q59PS6
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM C307130WA
gene id: 237561:CAALFM_C307130WA
uniprot id: A0A1D8PKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

237561:CAALFM C603210CA
gene id: 237561:CAALFM_C603210CA
uniprot id: A0A1D8PQ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

237561:CAALFM C101560WA
gene id: 237561:CAALFM_C101560WA
uniprot id: A0A1D8PCK0
names: Similarity
messages: Belongs to the PIAS family.

237561:CAALFM C601880WA
gene id: 237561:CAALFM_C601880WA
uniprot id: Q5A4P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

237561:CAALFM C209130CA
gene id: 237561:CAALFM_C209130CA
uniprot id: Q59XL0
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: Opaque-specific transcript. Repressed by HAP43 and induced by macrophages.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C700790WA
gene id: 237561:CAALFM_C700790WA
uniprot id: Q3MPQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Membrane
messages: Required for vacuolar protein sorting.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

237561:CAALFM C300710WA
gene id: 237561:CAALFM_C300710WA
uniprot id: A0A1D8PJ29
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C201380WA
gene id: 237561:CAALFM_C201380WA
uniprot id: A0A1D8PGF0
names: Similarity
messages: Belongs to the lysophospholipase family.

237561:CAALFM C602150CA
gene id: 237561:CAALFM_C602150CA
uniprot id: Q59S85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Forms homooligomers. Interacts with MRS2.
messages: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
messages: Mitochondrion inner membrane

237561:CAALFM C112100CA
gene id: 237561:CAALFM_C112100CA
uniprot id: A0A1D8PFB0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C208780WA
gene id: 237561:CAALFM_C208780WA
uniprot id: A0A1D8PI93
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C301340WA
gene id: 237561:CAALFM_C301340WA
uniprot id: Q5AJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C406170CA
gene id: 237561:CAALFM_C406170CA
uniprot id: Q5A199
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

237561:CAALFM C306390WA
gene id: 237561:CAALFM_C306390WA
uniprot id: A0A1D8PKH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: nucleolus

237561:CAALFM C301700WA
gene id: 237561:CAALFM_C301700WA
uniprot id: Q5AJB7
names: Similarity
messages: Belongs to the cullin family.

237561:CAALFM CR04240CA
gene id: 237561:CAALFM_CR04240CA
uniprot id: Q5A6P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

237561:CAALFM C111130WA
gene id: 237561:CAALFM_C111130WA
uniprot id: Q59WJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

237561:CAALFM C402430WA
gene id: 237561:CAALFM_C402430WA
uniprot id: Q5AFT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFT1 family.
messages: Nucleus
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).

237561:CAALFM C206430CA
gene id: 237561:CAALFM_C206430CA
uniprot id: Q59Q43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
messages: Mitochondrion inner membrane

237561:CAALFM C302310WA
gene id: 237561:CAALFM_C302310WA
uniprot id: A0A1D8PJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

237561:CAALFM C207380WA
gene id: 237561:CAALFM_C207380WA
uniprot id: P83784
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Mitochondrion matrix
messages: Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).

237561:CAALFM C504640CA
gene id: 237561:CAALFM_C504640CA
uniprot id: A0A1D8PP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Nucleus

237561:CAALFM C204340CA
gene id: 237561:CAALFM_C204340CA
uniprot id: Q59TB1
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

237561:CAALFM C502990WA
gene id: 237561:CAALFM_C502990WA
uniprot id: Q5AG55
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

237561:CAALFM CR07490CA
gene id: 237561:CAALFM_CR07490CA
uniprot id: Q59RR7
names: Similarity
messages: Belongs to the hexokinase family.

237561:CAALFM C400160CA
gene id: 237561:CAALFM_C400160CA
uniprot id: A0A1D8PL14
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C201690WA
gene id: 237561:CAALFM_C201690WA
uniprot id: Q5ALU6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C401720CA
gene id: 237561:CAALFM_C401720CA
uniprot id: Q5AMM4
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Homodimer; may form higher order oligomers. Interacts with the large RNA polymerase II subunit RPO21; the interaction is direct and serves to bridge RPO21 to the Elongin complex in a manner dependent on transcription stress. Interacts with RAD26.
messages: Nucleus
messages: Proteolytically cleaved by the proteasome in response to transcription stress; the resulting N-terminal form constitutes the activated nuclear form and the C-terminal portion is degraded.
messages: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.
messages: Translation C-terminally extended.
messages: Ubiquitinated.
messages: telomere

237561:CAALFM C204560WA
gene id: 237561:CAALFM_C204560WA
uniprot id: A0A1D8PH51
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

237561:CAALFM CR07210WA
gene id: 237561:CAALFM_CR07210WA
uniprot id: Q59RN2
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

237561:CAALFM CR06850CA
gene id: 237561:CAALFM_CR06850CA
uniprot id: A0A1D8PTB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

237561:CAALFM C203950WA
gene id: 237561:CAALFM_C203950WA
uniprot id: Q5AHG8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

237561:CAALFM C504130CA
gene id: 237561:CAALFM_C504130CA
uniprot id: P40953
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
messages: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
messages: Expression is positively regulated by BCR1 and FKH2. Transcription is greater during growth of the yeast form as compared to the mycelial form, and down-regulated by micafungin treatment.
messages: Leads to the clumping or clusterings of cells from early exponential phase, and to increased hyphal growth on solid media.
messages: Membrane
messages: Proteolytic cleavage by SAP9 and SAP10 leads to the cell wall release of CHT2 and increased chitinase activity, suggesting a direct influence of SAP9 and SAP10 on CHT2 function.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR00750CA
gene id: 237561:CAALFM_CR00750CA
uniprot id: Q5A847
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
messages: Nucleus
messages: The JmjC domain mediates the demethylation activity.

237561:CAALFM C101480CA
gene id: 237561:CAALFM_C101480CA
uniprot id: Q5A900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS2 is important for the assembly and function of the 40S ribosomal subunitand is nvolved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM CR06450WA
gene id: 237561:CAALFM_CR06450WA
uniprot id: Q59U11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Polynucleotide 5'-kinase involved in rRNA processing.
messages: nucleolus

237561:CAALFM C401280CA
gene id: 237561:CAALFM_C401280CA
uniprot id: A0A1D8PL91
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR10720WA
gene id: 237561:CAALFM_CR10720WA
uniprot id: A0A1D8PUB1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

237561:CAALFM C305920WA
gene id: 237561:CAALFM_C305920WA
uniprot id: Q5A4G2
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases MDR1 expression and leads to greater fluconazole and cerulenin susceptibility.
messages: Expression is coordinately up-regulated with MDR1 in drug-resistant, clinical isolates. Expression is induced by HAP43.
messages: Nucleus
messages: Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance.

237561:CAALFM C301320CA
gene id: 237561:CAALFM_C301320CA
uniprot id: Q5AJ73
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

237561:CAALFM C501610WA
gene id: 237561:CAALFM_C501610WA
uniprot id: Q59N30
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

237561:CAALFM CR07940WA
gene id: 237561:CAALFM_CR07940WA
uniprot id: Q59X73
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

237561:CAALFM C111030WA
gene id: 237561:CAALFM_C111030WA
uniprot id: A0A1D8PF11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the large ribosomal subunit (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit (By similarity). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (By similarity). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C403590CA
gene id: 237561:CAALFM_C403590CA
uniprot id: Q59TM0
names: Similarity
messages: Belongs to the OSBP family.

237561:CAALFM C201000WA
gene id: 237561:CAALFM_C201000WA
uniprot id: A0A1D8PG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR06540WA
gene id: 237561:CAALFM_CR06540WA
uniprot id: A0A1D8PT88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle

237561:CAALFM C405180CA
gene id: 237561:CAALFM_C405180CA
uniprot id: A0A1D8PM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

237561:CAALFM C109360CA
gene id: 237561:CAALFM_C109360CA
uniprot id: Q5APG7
names: Similarity
messages: Belongs to the EFR3 family.

237561:CAALFM C503400CA
gene id: 237561:CAALFM_C503400CA
uniprot id: A0A1D8PNP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

237561:CAALFM C400270WA
gene id: 237561:CAALFM_C400270WA
uniprot id: A0A1D8PKZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

237561:CAALFM C207240CA
gene id: 237561:CAALFM_C207240CA
uniprot id: Q59Z19
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

237561:CAALFM C406910WA
gene id: 237561:CAALFM_C406910WA
uniprot id: Q5A0X6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C305120CA
gene id: 237561:CAALFM_C305120CA
uniprot id: A0A1D8PK48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

237561:CAALFM CR07650WA
gene id: 237561:CAALFM_CR07650WA
uniprot id: Q59N42
names: Similarity
messages: Belongs to the PPP phosphatase family.

237561:CAALFM C300720WA
gene id: 237561:CAALFM_C300720WA
uniprot id: A0A1D8PJ01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

237561:CAALFM C204250WA
gene id: 237561:CAALFM_C204250WA
uniprot id: A0A1D8PH22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

237561:CAALFM CR09200CA
gene id: 237561:CAALFM_CR09200CA
uniprot id: A0A1D8PTY5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C406210CA
gene id: 237561:CAALFM_C406210CA
uniprot id: A0A1D8PMJ1
names: Function
names: Subcellular Location Annotation
messages: May be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion

237561:CAALFM C205760CA
gene id: 237561:CAALFM_C205760CA
uniprot id: Q59T30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM C208290CA
gene id: 237561:CAALFM_C208290CA
uniprot id: Q59KG2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGI1 family.
messages: Cell membrane
messages: Expression is under the control of RAS1. Up-regulated during colonization of the cecum and invasion of host tissue. Down-regulation correlates with clinical development of fluconazole resistance.
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.

237561:CAALFM C501750CA
gene id: 237561:CAALFM_C501750CA
uniprot id: Q71U11
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATA2 family.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific mating genes.
messages: Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
messages: Nucleus
messages: The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

237561:CAALFM C108580CA
gene id: 237561:CAALFM_C108580CA
uniprot id: Q59QB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuole membrane

237561:CAALFM CR03770CA
gene id: 237561:CAALFM_CR03770CA
uniprot id: A0A1D8PSK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS30 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM CR10270CA
gene id: 237561:CAALFM_CR10270CA
uniprot id: A0A1D8PU72
names: Similarity
messages: Belongs to the AHA1 family.

237561:CAALFM C703630CA
gene id: 237561:CAALFM_C703630CA
uniprot id: Q59R24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

237561:CAALFM C204060CA
gene id: 237561:CAALFM_C204060CA
uniprot id: A0A1D8PH27
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C400290CA
gene id: 237561:CAALFM_C400290CA
uniprot id: A0A1D8PL08
names: Function
names: Similarity
messages: Belongs to the choline monooxygenase family.
messages: Catalyzes the first step of the osmoprotectant glycine betaine synthesis.

237561:CAALFM CR08400CA
gene id: 237561:CAALFM_CR08400CA
uniprot id: Q5A357
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

237561:CAALFM CR00180CA
gene id: 237561:CAALFM_CR00180CA
uniprot id: Q5AAH2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
messages: Leads to increased hyphal growth on solid media.
messages: Secreted
messages: Transcription is greater during growth of the yeast form as compared to the mycelial form and up-regulated by micafungin treatment.

237561:CAALFM C601430CA
gene id: 237561:CAALFM_C601430CA
uniprot id: Q5A4K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C201470WA
gene id: 237561:CAALFM_C201470WA
uniprot id: Q5ALX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
messages: Nucleus

237561:CAALFM C304400CA
gene id: 237561:CAALFM_C304400CA
uniprot id: Q5ANL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

237561:CAALFM C500300CA
gene id: 237561:CAALFM_C500300CA
uniprot id: Q5A4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

237561:CAALFM C604500CA
gene id: 237561:CAALFM_C604500CA
uniprot id: A0A1D8PQF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

237561:CAALFM CR05390WA
gene id: 237561:CAALFM_CR05390WA
uniprot id: A0A1D8PT02
names: Similarity
messages: Belongs to the WrbA family.

237561:CAALFM C306000WA
gene id: 237561:CAALFM_C306000WA
uniprot id: Q5A4F3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MCM1.
messages: Nucleus
messages: Stabilizes the opaque phase.
messages: Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

237561:CAALFM C209590CA
gene id: 237561:CAALFM_C209590CA
uniprot id: Q59YD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C405100CA
gene id: 237561:CAALFM_C405100CA
uniprot id: Q59MQ0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Phosphorylation of the TEDS site (Ser-366) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity.
messages: The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.
messages: The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3). The IQ domain and the TH1 region are essential for hyphal growth and for endocytosis. The SH3 domain together with the TH3 region are required for the organization of the cortical actin.
messages: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity). Plays a role in chitin deposition in the cell wall, in determination of the budding pattern, and is required for hyphae formation.
messages: actin patch

237561:CAALFM CR02370WA
gene id: 237561:CAALFM_CR02370WA
uniprot id: O59933
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: C-4 methylsterol oxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:10783002). ERG25 is a catalytic component of the C-4 demethylation complex that catalyzes the conversion of 4,4-dimethylfecosterol into fecosterol via 4-methylfecosterol (PubMed:10783002). Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols (PubMed:10783002). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catal…
messages: Endoplasmic reticulum membrane
messages: Essential gene; conditional lethal mutations decrease the production of ergosterol and accumulate 4,4-dimethylzymosterol.
messages: Expression is induced by fluconazole and in azole-resistant strains (PubMed:15273122, PubMed:15820985). Expression is induced during biofilm formation (PubMed:15075282). Expression is up-regulated when ERG6, CYP51/ERG11 or ERG24 are deleted (PubMed:15473366).
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

237561:CAALFM C110290WA
gene id: 237561:CAALFM_C110290WA
uniprot id: O74254
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Membrane
messages: The N-terminus is blocked.
messages: cell wall

237561:CAALFM C111660WA
gene id: 237561:CAALFM_C111660WA
uniprot id: A0A1D8PF79
names: Similarity
messages: Belongs to the group II decarboxylase family.

237561:CAALFM C505400WA
gene id: 237561:CAALFM_C505400WA
uniprot id: Q5AJY4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

237561:CAALFM C601610WA
gene id: 237561:CAALFM_C601610WA
uniprot id: O94083
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Lys-51 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.

237561:CAALFM C404090CA
gene id: 237561:CAALFM_C404090CA
uniprot id: A0A1D8PM03
names: Similarity
messages: Belongs to the calreticulin family.

237561:CAALFM C103730CA
gene id: 237561:CAALFM_C103730CA
uniprot id: A0A1D8PD38
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

237561:CAALFM CR06150CA
gene id: 237561:CAALFM_CR06150CA
uniprot id: A0A1D8PT56
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

237561:CAALFM C108690WA
gene id: 237561:CAALFM_C108690WA
uniprot id: A0A1D8PEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

237561:CAALFM CR01800CA
gene id: 237561:CAALFM_CR01800CA
uniprot id: Q5A985
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity).
messages: Nucleus

237561:CAALFM C207360WA
gene id: 237561:CAALFM_C207360WA
uniprot id: Q59U53
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

237561:CAALFM CR04300WA
gene id: 237561:CAALFM_CR04300WA
uniprot id: A0A1D8PSR2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

237561:CAALFM C601100WA
gene id: 237561:CAALFM_C601100WA
uniprot id: Q59XP0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.
messages: Leads to defects in secretion of degradative enzymes and defects in hyphal extension.
messages: Membrane

237561:CAALFM C200800CA
gene id: 237561:CAALFM_C200800CA
uniprot id: Q5AD23
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C405630WA
gene id: 237561:CAALFM_C405630WA
uniprot id: Q5A462
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

237561:CAALFM C105680CA
gene id: 237561:CAALFM_C105680CA
uniprot id: Q5AA01
names: Subcellular Location Annotation
messages: Mitochondrion

237561:CAALFM C302150CA
gene id: 237561:CAALFM_C302150CA
uniprot id: O74198
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Does not affect the susceptibility to azoles (PubMed:9593144). Leads to hypersensitivity to cyclosporin A (CsA) and FK506, inhibitors of the protein phosphatase calcineurin (PubMed:11847103).
messages: Expression is induced in the presence of fluconazole and up-regulated in azole-resistant strain (PubMed:15820985). Expression is positively regulated by the transcription regulator HAP43 (PubMed:21592964). Expression is also induced by N-acetyl-D-glucosamine (PubMed:22406769). Expression is repressed during spider biofilm formation (PubMed:22265407).
messages: Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:9593144, PubMed:20946868). ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol (PubMed:9593144, PubMed:20946868). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsi…
messages: Substrate analogs 25-azalanosterol and 24(R,S),25-epiminolanosterol act as inhibitors.

237561:CAALFM C210620WA
gene id: 237561:CAALFM_C210620WA
uniprot id: Q5A5Q8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

237561:CAALFM C300170CA
gene id: 237561:CAALFM_C300170CA
uniprot id: Q5A7L0
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C404900WA
gene id: 237561:CAALFM_C404900WA
uniprot id: A0A1D8PM75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C404530CA
gene id: 237561:CAALFM_C404530CA
uniprot id: P43076
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism.
messages: Strongly expressed under conditions of alkaline pH but not expressed at any pH below 5.5.

237561:CAALFM C113110CA
gene id: 237561:CAALFM_C113110CA
uniprot id: A0A1D8PFK5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C103870CA
gene id: 237561:CAALFM_C103870CA
uniprot id: A0A1D8PD58
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM CR07440WA
gene id: 237561:CAALFM_CR07440WA
uniprot id: Q59RR0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection.

237561:CAALFM C106040WA
gene id: 237561:CAALFM_C106040WA
uniprot id: A0A1D8PDR1
names: Similarity
messages: Belongs to the cullin family.

237561:CAALFM C403930CA
gene id: 237561:CAALFM_C403930CA
uniprot id: A0A1D8PLY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

237561:CAALFM C500030WA
gene id: 237561:CAALFM_C500030WA
uniprot id: A0A1D8PMT8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

237561:CAALFM C106840CA
gene id: 237561:CAALFM_C106840CA
uniprot id: A0A1D8PDY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

237561:CAALFM C600750CA
gene id: 237561:CAALFM_C600750CA
uniprot id: P46273
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.
messages: cell wall

237561:CAALFM C112530CA
gene id: 237561:CAALFM_C112530CA
uniprot id: A0A1D8PFF7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C700090CA
gene id: 237561:CAALFM_C700090CA
uniprot id: G1UB63
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation.
messages: Membrane
messages: Preferentially expressed during the mycelial growth phase with only low levels of transcript detected in the yeast form. Induced by iron starvation and ciclopirox. Positively regulated by BCR1 and RIM101, and repressed by TUP1. Expression is also regulated by EFG1, CPH1, HAP43, and SEF1.
messages: The CFEM domain is involved in heme-binding. It contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C401700CA
gene id: 237561:CAALFM_C401700CA
uniprot id: Q9UVL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
messages: Nucleus
messages: Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.

237561:CAALFM C503770CA
gene id: 237561:CAALFM_C503770CA
uniprot id: A0A1D8PNS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM C105810WA
gene id: 237561:CAALFM_C105810WA
uniprot id: Q5AA13
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

237561:CAALFM C106930WA
gene id: 237561:CAALFM_C106930WA
uniprot id: Q5AAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Endoplasmic reticulum membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity).

237561:CAALFM C105960WA
gene id: 237561:CAALFM_C105960WA
uniprot id: Q5AA33
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expression is induced by HOG1 and during biofoilm formation, and repressed by caspofungin. Also regulated by SSN6.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C306870WA
gene id: 237561:CAALFM_C306870WA
uniprot id: Q5ADM7
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

237561:CAALFM C109750WA
gene id: 237561:CAALFM_C109750WA
uniprot id: P0CB63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET2 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

237561:CAALFM C601120CA
gene id: 237561:CAALFM_C601120CA
uniprot id: A0A1D8PPI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C209350WA
gene id: 237561:CAALFM_C209350WA
uniprot id: A0A1D8PIG7
names: Similarity
messages: Belongs to the taffazin family.

237561:CAALFM CR04650WA
gene id: 237561:CAALFM_CR04650WA
uniprot id: A0A1D8PST9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

237561:CAALFM C402480CA
gene id: 237561:CAALFM_C402480CA
uniprot id: Q5AF54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

237561:CAALFM CR01950WA
gene id: 237561:CAALFM_CR01950WA
uniprot id: A0A1D8PS34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

237561:CAALFM C210470CA
gene id: 237561:CAALFM_C210470CA
uniprot id: Q5A5S7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Expression is induced during biofilm formation.
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Plays a key role in autophagy (PubMed:36476055). Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling (By similarity). Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation (By similarity). Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity). Finally, plays an important role in biofilm formation and resistance to antifungal compounds such as fluconazole, itraconazole, terbinafine and caspofungin (PubMed:36476055).
messages: Preautophagosomal structure membrane
messages: Reduces the formation of biofilms (PubMed:36476055). Significantly decreases the resistance of biofilms to fluconazole, itraconazole, terbinafine and caspofungin (PubMed:36476055). Leads to autophagosomes with shrunken membranes with undefined edges (PubMed:36476055). Results also in partially dissolved contents of autophagosomes (PubMed:36476055).

237561:CAALFM CR07960CA
gene id: 237561:CAALFM_CR07960CA
uniprot id: A0A1D8PTL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

237561:CAALFM C202420CA
gene id: 237561:CAALFM_C202420CA
uniprot id: Q5ALL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C603730CA
gene id: 237561:CAALFM_C603730CA
uniprot id: A0A1D8PQ89
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

237561:CAALFM C110490WA
gene id: 237561:CAALFM_C110490WA
uniprot id: Q59NB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C303070WA
gene id: 237561:CAALFM_C303070WA
uniprot id: A0A1D8PJN2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C502820CA
gene id: 237561:CAALFM_C502820CA
uniprot id: Q5AG73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

237561:CAALFM C306060WA
gene id: 237561:CAALFM_C306060WA
uniprot id: A0A1D8PKD5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

237561:CAALFM C304390WA
gene id: 237561:CAALFM_C304390WA
uniprot id: A0A1D8PK00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

237561:CAALFM C305220WA
gene id: 237561:CAALFM_C305220WA
uniprot id: Q5ANA3
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Contains 2 cytoplasmic nucleotide binding domains (NBDs). The N-terminal NBD has ATPase activity. The 2 NBDs are asymmetric and non-exchangeable and the drug efflux by CDR1 involves complex interactions between the two halves of the protein.
messages: Disulfiram reverses CDR1-mediated drug resistance by interaction with both ATP and substrate-binding sites of the transporter and may be useful for antifungal therapy.
messages: Leads to hypersusceptibility to the antifungal agents terbinafine and amorolfine, and to the metabolic inhibitors cycloheximide, brefeldin A, and fluphenazine. Shows a decreased number of germ tube-forming cells in the presence of estradiol when CDR2 is also deleted.
messages: Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen. Plays a role in farnesol-induced apoptotic process through glutathione efflux activity. Mediates in-to-out translocation of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine. Exhibits nucleoside triphosphatase activity.
messages: The distal promoter mediates the miconazole response whereas the proximal promoter (-345/+1) contains all the regulatory domains required for its induction by various other stresses. The promoter also contains a steroid responsive region (SRR) conferring beta-oestradiol and progesterone inducibility. Transcription is positively regulated by NCB2, NTD80 and TAC1 and repressed by FCR1. Expression is up-regulated during biofilm development, by heat-shock, and by benomyl, doxorubicin, miconazole, vinblastine, adriamycin, fluphenazine, cycloheximide, calcofluor, canavanine, 5'-fluorcytosine, cilofungin and caffeine. Expression is repressed by serum and inhibited by tetrandrine. Transcription is also reduced during in vitro fluconazole exposure but in the postexposure period, the mRNA abundance increases.

237561:CAALFM C103430WA
gene id: 237561:CAALFM_C103430WA
uniprot id: Q5AI09
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

237561:CAALFM C209230CA
gene id: 237561:CAALFM_C209230CA
uniprot id: Q59X47
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

237561:CAALFM CR06560CA
gene id: 237561:CAALFM_CR06560CA
uniprot id: A0A1D8PT90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

237561:CAALFM C102750CA
gene id: 237561:CAALFM_C102750CA
uniprot id: A0A1D8PCV8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C303300CA
gene id: 237561:CAALFM_C303300CA
uniprot id: Q5AED9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
messages: Nucleus

237561:CAALFM C703040WA
gene id: 237561:CAALFM_C703040WA
uniprot id: G1UB62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C401150WA
gene id: 237561:CAALFM_C401150WA
uniprot id: Q5AMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex ASK1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

237561:CAALFM C303760WA
gene id: 237561:CAALFM_C303760WA
uniprot id: Q59SS8
names: Similarity
messages: Belongs to the diacylglycerol acyltransferase family.

237561:CAALFM C303140CA
gene id: 237561:CAALFM_C303140CA
uniprot id: A0A1D8PJM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM C111470CA
gene id: 237561:CAALFM_C111470CA
uniprot id: Q59W68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

237561:CAALFM CR01290CA
gene id: 237561:CAALFM_CR01290CA
uniprot id: A0A1D8PRY4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR00610WA
gene id: 237561:CAALFM_CR00610WA
uniprot id: Q5AAL9
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence. Plays a role in adherence to plastic and to host epithelial cells. Promotes the tissue fungal burden during murine vaginal candidiasis. Increases also susceptibility to neutrophil-mediated killing. Furthermore, contributes to the severity of hematogenously disseminated candidiasis in normal mice, but not in neutropenic mice.
messages: Leads to decreased adherence of germ tubes to plastic and epithelial cells, but not endothelial cells.
messages: Membrane
messages: Repressed by HAP43 and in absence of GOA1.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-$modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR04000WA
gene id: 237561:CAALFM_CR04000WA
uniprot id: Q5A6S2
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C406880CA
gene id: 237561:CAALFM_C406880CA
uniprot id: A0A1D8PMQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

237561:CAALFM C400940WA
gene id: 237561:CAALFM_C400940WA
uniprot id: A0A1D8PL76
names: Similarity
messages: Belongs to the ELP6 family.

237561:CAALFM C206680WA
gene id: 237561:CAALFM_C206680WA
uniprot id: A0A1D8PHP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C113850CA
gene id: 237561:CAALFM_C113850CA
uniprot id: Q5AKV4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C104310CA
gene id: 237561:CAALFM_C104310CA
uniprot id: Q59VM7
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expression is induced by N-acetylglucosamine (GlcNAc).
messages: Leads to increased resistance to the chitin synthase inhibitor nikkomycin Z.
messages: N-acetylglucosamine-induced protein which plays a role in the N-acetylglucosamine metabolic pathway.

237561:CAALFM C201090CA
gene id: 237561:CAALFM_C201090CA
uniprot id: Q5AD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25, ERG26 and ERG27. Also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11.
messages: Part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG28 has a role as a scaffold to help anchor the catalytic components of the C-4 demethylation complex ERG25, ERG26 and ERG27 to the endoplasmic reticulum (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduct…

237561:CAALFM CR08210CA
gene id: 237561:CAALFM_CR08210CA
uniprot id: P82611
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle.
messages: Mitochondrion
messages: Monomer.

237561:CAALFM C209180WA
gene id: 237561:CAALFM_C209180WA
uniprot id: A0A1D8PIB8
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

237561:CAALFM C210100WA
gene id: 237561:CAALFM_C210100WA
uniprot id: Q59XY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC22 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM CR02940CA
gene id: 237561:CAALFM_CR02940CA
uniprot id: Q5A1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C102410CA
gene id: 237561:CAALFM_C102410CA
uniprot id: A0A1D8PCS2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C306980WA
gene id: 237561:CAALFM_C306980WA
uniprot id: Q5ADN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).

237561:CAALFM C102230WA
gene id: 237561:CAALFM_C102230WA
uniprot id: Q59VX8
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck
messages: Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SEP7. The purified septin complex appeared to have a stoichiometry of 2 CDC3, 1 to 2 CDC10, 1 CDC11, 2 CDC12, and 1 or none SEP7 subunit. Induction of hyphal growth brings about important modifications in septin ring dynamics, because the rings were found in a different state from those of yeast cells. This hyphal-specific state contains a core of stable septins (SEP7, CDC3, and CDC12), and it shows a high CDC10 turnover between the ring and the cytoplasm. Interacts with GIN4.
messages: Leads to a minor reduction in agar invasion ability.
messages: Phosphorylated by GIN4 which stabilizes the GIN4-SEP7 interaction.
messages: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinase GIN4. Septins are also involved in cell morphogenesis, chlamydospores morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation. SEP7 is required to convert hyphal septin rings into the hyphal-specific state and is necessary for CDC10 turnover during hyphal growth.

237561:CAALFM C103490WA
gene id: 237561:CAALFM_C103490WA
uniprot id: Q5AI01
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C102910CA
gene id: 237561:CAALFM_C102910CA
uniprot id: Q5AI71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Preautophagosomal structure membrane

237561:CAALFM CR07420WA
gene id: 237561:CAALFM_CR07420WA
uniprot id: A0A1D8PTH3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

237561:CAALFM C602900CA
gene id: 237561:CAALFM_C602900CA
uniprot id: A0A1D8PQ09
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

237561:CAALFM CR07450CA
gene id: 237561:CAALFM_CR07450CA
uniprot id: Q59RR3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1.

237561:CAALFM C603700WA
gene id: 237561:CAALFM_C603700WA
uniprot id: Q5A8T4
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.
messages: Highly expressed in biofilms with down-regulation during later stages of biofilm formation. Expression is repressed by TPK1 and SFL1, and induced by TPK2. Also under the control of TOR1. Down-regulated by Riccardin D, a macrocyclic bisbibenzyl isolated from Chinese liverwort D.hirsute which has an inhibitory effect on biofilms and virulence. Induced by caspofungin.
messages: Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR00990WA
gene id: 237561:CAALFM_CR00990WA
uniprot id: Q5A869
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.

237561:CAALFM C200830CA
gene id: 237561:CAALFM_C200830CA
uniprot id: A0A1D8PG88
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C403520CA
gene id: 237561:CAALFM_C403520CA
uniprot id: Q59TP1
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HWP1 family.
messages: Expression is negatively regulated by the TUP1 transcriptional repressor. Also regulated by EFG1, RFG1 and RIM101. Induced during hyphal growth, during mating process, under alkaline conditions, and by farnesol. Repressed by fluconazole.
messages: GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence. Involved in normal disseminated infection, but not in intestinal colonization.
messages: Leads to hypersensitivity to calcofluor white (CFW).
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C502650CA
gene id: 237561:CAALFM_C502650CA
uniprot id: Q5AG97
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFH1 family.
messages: In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.
messages: Induced during biofilm formation.
messages: Interacts with FLH1 and TBF1.
messages: Nucleus

237561:CAALFM C701290WA
gene id: 237561:CAALFM_C701290WA
uniprot id: Q59S43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C406560WA
gene id: 237561:CAALFM_C406560WA
uniprot id: Q5A1E1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment. Expression is also regulated by CWT1.
messages: cell wall

237561:CAALFM C103670CA
gene id: 237561:CAALFM_C103670CA
uniprot id: A0A1D8PD33
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

237561:CAALFM C208630CA
gene id: 237561:CAALFM_C208630CA
uniprot id: Q59Y36
names: Similarity
messages: Belongs to the PAF1 family.

237561:CAALFM CR07810WA
gene id: 237561:CAALFM_CR07810WA
uniprot id: Q59MV6
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

237561:CAALFM C700480WA
gene id: 237561:CAALFM_C700480WA
uniprot id: A0A1D8PQL0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

237561:CAALFM C503830CA
gene id: 237561:CAALFM_C503830CA
uniprot id: A0A1D8PNT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

237561:CAALFM C108370WA
gene id: 237561:CAALFM_C108370WA
uniprot id: Q5A744
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: By the antifungal drug fluconazole.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.
messages: Nucleus

237561:CAALFM C110930CA
gene id: 237561:CAALFM_C110930CA
uniprot id: Q59WH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

237561:CAALFM C404390WA
gene id: 237561:CAALFM_C404390WA
uniprot id: A0A1D8PM41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C502720WA
gene id: 237561:CAALFM_C502720WA
uniprot id: A0A1D8PNI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM C114330WA
gene id: 237561:CAALFM_C114330WA
uniprot id: A0A1D8PFW8
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

237561:CAALFM C504120CA
gene id: 237561:CAALFM_C504120CA
uniprot id: A0A1D8PNV3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

237561:CAALFM C700630CA
gene id: 237561:CAALFM_C700630CA
uniprot id: A0A1D8PQM7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C200850WA
gene id: 237561:CAALFM_C200850WA
uniprot id: Q5AD28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

237561:CAALFM CR10330WA
gene id: 237561:CAALFM_CR10330WA
uniprot id: Q5ACN3
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C702810WA
gene id: 237561:CAALFM_C702810WA
uniprot id: Q5A5A0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

237561:CAALFM C604050WA
gene id: 237561:CAALFM_C604050WA
uniprot id: A0A1D8PQB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.

237561:CAALFM C501420WA
gene id: 237561:CAALFM_C501420WA
uniprot id: A0A1D8PN67
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

237561:CAALFM CR05340CA
gene id: 237561:CAALFM_CR05340CA
uniprot id: A0A1D8PSZ0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C200940WA
gene id: 237561:CAALFM_C200940WA
uniprot id: Q5AD37
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

237561:CAALFM CR08930CA
gene id: 237561:CAALFM_CR08930CA
uniprot id: A0A1D8PTV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

237561:CAALFM C100340WA
gene id: 237561:CAALFM_C100340WA
uniprot id: Q8TG40
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation (By similarity). Induces transcription of mating-type proteins ALPHA1 and ALPHA2 and moderately represses transcription of mating-type protein A1 in response to hemoglobin and growth signals. Involved in the induction of a high affinity fibronectin receptor by sub-inhibitory dosages of caspofungin.
messages: Cytoplasm
messages: Induced in the presence of exogenous hemoglobin and during the exponential growth phase and by cold-stress.
messages: Nucleus

237561:CAALFM C210250CA
gene id: 237561:CAALFM_C210250CA
uniprot id: Q59XV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
messages: Nucleus
messages: The AWS and SET domains are necessary for transcription repression.

237561:CAALFM C207560WA
gene id: 237561:CAALFM_C207560WA
uniprot id: Q59U81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Component of the SWR1 chromatin-remodeling complex.
messages: Nucleus

237561:CAALFM C404500CA
gene id: 237561:CAALFM_C404500CA
uniprot id: Q5A653
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

237561:CAALFM C402530WA
gene id: 237561:CAALFM_C402530WA
uniprot id: A0A1D8PLL5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C203070CA
gene id: 237561:CAALFM_C203070CA
uniprot id: Q5A0L9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
messages: Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
messages: Endoplasmic reticulum membrane
messages: May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

237561:CAALFM C302680CA
gene id: 237561:CAALFM_C302680CA
uniprot id: Q5AEK8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.
messages: Has a decreased hyphal growth rate and is highly sensitive to SDS and fluconazole.
messages: Membrane

237561:CAALFM C404980WA
gene id: 237561:CAALFM_C404980WA
uniprot id: Q5A6A8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C208070CA
gene id: 237561:CAALFM_C208070CA
uniprot id: Q5A2T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C600240CA
gene id: 237561:CAALFM_C600240CA
uniprot id: A0A1D8PPA3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C203960WA
gene id: 237561:CAALFM_C203960WA
uniprot id: A0A1D8PH21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C207480WA
gene id: 237561:CAALFM_C207480WA
uniprot id: A0A1D8PHX1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C603450CA
gene id: 237561:CAALFM_C603450CA
uniprot id: A0A1D8PQ56
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C102710WA
gene id: 237561:CAALFM_C102710WA
uniprot id: A0A1D8PCT4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

237561:CAALFM C300830CA
gene id: 237561:CAALFM_C300830CA
uniprot id: A0A1D8PJ08
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

237561:CAALFM C304770CA
gene id: 237561:CAALFM_C304770CA
uniprot id: Q5ANG4
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C501360WA
gene id: 237561:CAALFM_C501360WA
uniprot id: A0A1D8PN54
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C600760WA
gene id: 237561:CAALFM_C600760WA
uniprot id: Q59NN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FES1 family.
messages: Cytoplasm
messages: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).

237561:CAALFM CR03940WA
gene id: 237561:CAALFM_CR03940WA
uniprot id: Q59JU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

237561:CAALFM C111110CA
gene id: 237561:CAALFM_C111110CA
uniprot id: A0A1D8PF30
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

237561:CAALFM C305140CA
gene id: 237561:CAALFM_C305140CA
uniprot id: Q5ANB6
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

237561:CAALFM C108860CA
gene id: 237561:CAALFM_C108860CA
uniprot id: A0A1D8PEF4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

237561:CAALFM C400240CA
gene id: 237561:CAALFM_C400240CA
uniprot id: A0A1D8PKZ7
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

237561:CAALFM C302360CA
gene id: 237561:CAALFM_C302360CA
uniprot id: A0A1D8PJI5
names: Similarity
messages: Belongs to the sulfatase family.

237561:CAALFM C111450CA
gene id: 237561:CAALFM_C111450CA
uniprot id: A0A1D8PF68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

237561:CAALFM C305190CA
gene id: 237561:CAALFM_C305190CA
uniprot id: Q5ANA8
names: Function
names: Similarity
messages: Belongs to the peptidase C14B family.
messages: Involved in cell death (apoptosis).

237561:CAALFM C404030WA
gene id: 237561:CAALFM_C404030WA
uniprot id: A0A1D8PLY7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

237561:CAALFM C204690CA
gene id: 237561:CAALFM_C204690CA
uniprot id: A0A1D8PH79
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404910CA
gene id: 237561:CAALFM_C404910CA
uniprot id: A0A1D8PM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC34 family.
messages: Nucleus
messages: kinetochore
messages: spindle

237561:CAALFM C300350WA
gene id: 237561:CAALFM_C300350WA
uniprot id: Q5A7N4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

237561:CAALFM C110660WA
gene id: 237561:CAALFM_C110660WA
uniprot id: O43133
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus

237561:CAALFM C505030CA
gene id: 237561:CAALFM_C505030CA
uniprot id: Q5AK25
names: Function
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

237561:CAALFM CR02720CA
gene id: 237561:CAALFM_CR02720CA
uniprot id: A0A1D8PS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

237561:CAALFM C205090WA
gene id: 237561:CAALFM_C205090WA
uniprot id: Q59ZH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

237561:CAALFM C205440WA
gene id: 237561:CAALFM_C205440WA
uniprot id: Q59ZE6
names: Subcellular Location Annotation
messages: Peroxisome membrane
messages: cytosol

237561:CAALFM C303100CA
gene id: 237561:CAALFM_C303100CA
uniprot id: Q5AEG1
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C112580WA
gene id: 237561:CAALFM_C112580WA
uniprot id: A0A1D8PFF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

237561:CAALFM C704330CA
gene id: 237561:CAALFM_C704330CA
uniprot id: A0A1D8PRK2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C113960WA
gene id: 237561:CAALFM_C113960WA
uniprot id: Q5AKU3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YBP1 family.
messages: Cytoplasm
messages: Interacts with CAP1.
messages: Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of CAP1. Functions probably in concert with GPX3, the actual CAP1 modifying enzyme.
messages: Leads to decreased virulence in a Galleria mellonella model.

237561:CAALFM C112360CA
gene id: 237561:CAALFM_C112360CA
uniprot id: Q5A3V6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: S-glutathionylation is reversible and dependent on a glutaredoxin.

237561:CAALFM C602650CA
gene id: 237561:CAALFM_C602650CA
uniprot id: A0A1D8PPX9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C108090CA
gene id: 237561:CAALFM_C108090CA
uniprot id: Q5A782
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

237561:CAALFM C703600WA
gene id: 237561:CAALFM_C703600WA
uniprot id: Q59R28
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Leads to sensitivity to calcofluor white and SDS, as well as to thermosensitivity.

237561:CAALFM C602640CA
gene id: 237561:CAALFM_C602640CA
uniprot id: A0A1D8PPZ5
names: Function
names: Similarity
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.

237561:CAALFM C303650WA
gene id: 237561:CAALFM_C303650WA
uniprot id: Q59SR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
messages: nucleolus

237561:CAALFM C603830WA
gene id: 237561:CAALFM_C603830WA
uniprot id: A0A1D8PQA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

237561:CAALFM C700490CA
gene id: 237561:CAALFM_C700490CA
uniprot id: A0A1D8PQL1
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

237561:CAALFM CR10300WA
gene id: 237561:CAALFM_CR10300WA
uniprot id: A0A1D8PU67
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

237561:CAALFM CR04420CA
gene id: 237561:CAALFM_CR04420CA
uniprot id: Q5A6M2
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP1/TIP1 family.
messages: Expression is regulated upon white-opaque switching. Repressed by RIM101 and alpha pheromone, and up-regulated upon interaction with macrophages.
messages: Membrane
messages: Probable cell wall protein which may have esterase activity, with a preference for esters of fatty acids from 4 to 16 carbon atoms.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C200290WA
gene id: 237561:CAALFM_C200290WA
uniprot id: Q5ACW3
names: Similarity
messages: Belongs to the HscB family.

237561:CAALFM C100740CA
gene id: 237561:CAALFM_C100740CA
uniprot id: P78599
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Cytoplasm
messages: Homodimer (By similarity). Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (By similarity).
messages: Inhibited by antizyme (AZ) OAZ1 in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

237561:CAALFM C300780WA
gene id: 237561:CAALFM_C300780WA
uniprot id: A0A1D8PJ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

237561:CAALFM CR09910WA
gene id: 237561:CAALFM_CR09910WA
uniprot id: A0A1D8PU34
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR06830CA
gene id: 237561:CAALFM_CR06830CA
uniprot id: Q59MU0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

237561:CAALFM C702960CA
gene id: 237561:CAALFM_C702960CA
uniprot id: A0A1D8PR82
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

237561:CAALFM C501050CA
gene id: 237561:CAALFM_C501050CA
uniprot id: A0A1D8PN49
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

237561:CAALFM CR06790CA
gene id: 237561:CAALFM_CR06790CA
uniprot id: Q59MT5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C108850CA
gene id: 237561:CAALFM_C108850CA
uniprot id: A0A1D8PEE3
names: Similarity
messages: Belongs to the AFG1 ATPase family.

237561:CAALFM C102000WA
gene id: 237561:CAALFM_C102000WA
uniprot id: A0A1D8PCP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

237561:CAALFM CR03950WA
gene id: 237561:CAALFM_CR03950WA
uniprot id: Q5A6S7
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.

237561:CAALFM C402590CA
gene id: 237561:CAALFM_C402590CA
uniprot id: Q5AFV3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Forms a heterodimer with SLX1.
messages: Nucleus
messages: Phosphorylated in response to DNA damage.
messages: Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

237561:CAALFM C306250WA
gene id: 237561:CAALFM_C306250WA
uniprot id: Q5A302
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

237561:CAALFM C105290WA
gene id: 237561:CAALFM_C105290WA
uniprot id: Q5A2A5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C306810WA
gene id: 237561:CAALFM_C306810WA
uniprot id: Q5ADM0
names: Similarity
messages: Belongs to the cullin family.

237561:CAALFM C600190WA
gene id: 237561:CAALFM_C600190WA
uniprot id: Q59S27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RTT106 family.
messages: Chromosome
messages: Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
messages: Interacts with histones H3 and H4.
messages: Nucleus

237561:CAALFM C105490CA
gene id: 237561:CAALFM_C105490CA
uniprot id: Q5A2C6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

237561:CAALFM C301830CA
gene id: 237561:CAALFM_C301830CA
uniprot id: P46592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 15 family.
messages: Golgi apparatus membrane
messages: Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Mainly responsible for the addition of the third mannose residue in an O-linked mannose pentamer. Can also substitute for MNT1 by adding the second mannose residue. Important for adherence to host surfaces and for virulence.

237561:CAALFM C100220WA
gene id: 237561:CAALFM_C100220WA
uniprot id: O13318
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Repressed at pH values above 6 and progressively induced at more acidic pH values.
messages: Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity).

237561:CAALFM C102580WA
gene id: 237561:CAALFM_C102580WA
uniprot id: A0A1D8PCS6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C205940CA
gene id: 237561:CAALFM_C205940CA
uniprot id: Q59MF4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

237561:CAALFM C208370CA
gene id: 237561:CAALFM_C208370CA
uniprot id: P0CY35
uniprot id: Q59QD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

237561:CAALFM C504680WA
gene id: 237561:CAALFM_C504680WA
uniprot id: Q5AK66
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A psd1 psd2 double mutant displays diminished phosphatidylethanolamine levels. It exhibits defects in cell wall integrity, mitochondrial function, filamentous growth and is less virulent than the wild-type.
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Important for virulence (PubMed:20132453).
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function.

237561:CAALFM C500480CA
gene id: 237561:CAALFM_C500480CA
uniprot id: P46250
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).

237561:CAALFM C306510CA
gene id: 237561:CAALFM_C306510CA
uniprot id: A0A1D8PKI5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR08490WA
gene id: 237561:CAALFM_CR08490WA
uniprot id: Q5A346
names: Subcellular Location Annotation
messages: nucleolus

237561:CAALFM C307060WA
gene id: 237561:CAALFM_C307060WA
uniprot id: Q5ADP7
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

237561:CAALFM C201590WA
gene id: 237561:CAALFM_C201590WA
uniprot id: Q5ALV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR03140CA
gene id: 237561:CAALFM_CR03140CA
uniprot id: A0A1D8PSE4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C401940WA
gene id: 237561:CAALFM_C401940WA
uniprot id: Q5AMP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

237561:CAALFM C100120CA
gene id: 237561:CAALFM_C100120CA
uniprot id: P43073
names: Similarity
messages: Belongs to the TrpF family.

237561:CAALFM C209370CA
gene id: 237561:CAALFM_C209370CA
uniprot id: A0A1D8PIH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

237561:CAALFM C207840WA
gene id: 237561:CAALFM_C207840WA
uniprot id: A0A1D8PI45
names: Similarity
messages: Belongs to the FMO family.

237561:CAALFM CR02040WA
gene id: 237561:CAALFM_CR02040WA
uniprot id: Q5A961
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Leads to increased caspofungin sensitivity.
messages: Protein kinase involved in regulation of actin cytoskeleton organization and endocytosis. Phosphorylates the endocytic protein SLA1. The CDC28-CLN3 complex phosphorylation of SLA1 enhances its further phosphorylation by PRK1, weakening SLA1 association with PAN1, an activator of the actin-nucleating ARP2/3 complex. Plays a role in cell wall regulation and required for oxidative stress survival.
messages: actin patch

237561:CAALFM C305340WA
gene id: 237561:CAALFM_C305340WA
uniprot id: Q59YV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

237561:CAALFM C405260WA
gene id: 237561:CAALFM_C405260WA
uniprot id: A0A1D8PMB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Cytoplasm

237561:CAALFM C101780CA
gene id: 237561:CAALFM_C101780CA
uniprot id: A0A1D8PCL5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C102110CA
gene id: 237561:CAALFM_C102110CA
uniprot id: Q59VZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C108620WA
gene id: 237561:CAALFM_C108620WA
uniprot id: A0A1D8PEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

237561:CAALFM C207660WA
gene id: 237561:CAALFM_C207660WA
uniprot id: A0A1D8PHZ6
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C701030CA
gene id: 237561:CAALFM_C701030CA
uniprot id: A0A1D8PQQ7
names: Similarity
messages: Belongs to the RRP12 family.

237561:CAALFM C205520WA
gene id: 237561:CAALFM_C205520WA
uniprot id: A0A1D8PHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

237561:CAALFM C700800CA
gene id: 237561:CAALFM_C700800CA
uniprot id: Q9P840
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: May form a complex with LTO1.
messages: Nucleus
messages: The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.

237561:CAALFM C407040WA
gene id: 237561:CAALFM_C407040WA
uniprot id: A0A1D8PMR7
names: Similarity
messages: Belongs to the cytochrome P450 family.

237561:CAALFM C112920CA
gene id: 237561:CAALFM_C112920CA
uniprot id: A0A1D8PFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM CR09220CA
gene id: 237561:CAALFM_CR09220CA
uniprot id: Q9P4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C602340WA
gene id: 237561:CAALFM_C602340WA
uniprot id: Q59S64
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM CR07590WA
gene id: 237561:CAALFM_CR07590WA
uniprot id: Q59V63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

237561:CAALFM C600620WA
gene id: 237561:CAALFM_C600620WA
uniprot id: P78594
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

237561:CAALFM C204940CA
gene id: 237561:CAALFM_C204940CA
uniprot id: A0A1D8PH98
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Decreases myo-inositol import into cell (PubMed:18268031). Virulence is not affected in a mouse model of disseminated infection (PubMed:18268031). Simultaneous disruption of INO1 results in lethality (PubMed:18268031).
messages: Major transporter for myo-inositol.

237561:CAALFM CR03580CA
gene id: 237561:CAALFM_CR03580CA
uniprot id: Q5A001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C407220CA
gene id: 237561:CAALFM_C407220CA
uniprot id: A0A1D8PMS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

237561:CAALFM C304580CA
gene id: 237561:CAALFM_C304580CA
uniprot id: Q5ANI6
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain.
messages: Cell membrane
messages: Expression is down-regulated in presence of extracellular amino acids.
messages: Impairs expression of SAP2 and OPT1. Impairs virulence in Drosophila as a host model.
messages: Nucleus
messages: Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes.

237561:CAALFM C504090CA
gene id: 237561:CAALFM_C504090CA
uniprot id: Q59LQ6
names: Similarity
messages: Belongs to the SUI1 family.

237561:CAALFM CR00330CA
gene id: 237561:CAALFM_CR00330CA
uniprot id: A0A1D8PRN3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C101820CA
gene id: 237561:CAALFM_C101820CA
uniprot id: Q59T89
names: Similarity
messages: Belongs to the cyclin family.

237561:CAALFM C406660WA
gene id: 237561:CAALFM_C406660WA
uniprot id: A0A1D8PMN0
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C307090WA
gene id: 237561:CAALFM_C307090WA
uniprot id: Q5ADQ0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

237561:CAALFM C303050CA
gene id: 237561:CAALFM_C303050CA
uniprot id: Q5AEG7
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGA18 family.
messages: Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence (By similarity).
messages: Expression in regulated by NRG1 and TUP1.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C604550CA
gene id: 237561:CAALFM_C604550CA
uniprot id: Q59RH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

237561:CAALFM C302690CA
gene id: 237561:CAALFM_C302690CA
uniprot id: A0A1D8PJH3
names: Similarity
messages: Belongs to the polyprenol kinase family.

237561:CAALFM C306400CA
gene id: 237561:CAALFM_C306400CA
uniprot id: A0A1D8PKH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

237561:CAALFM C101620CA
gene id: 237561:CAALFM_C101620CA
uniprot id: A0A1D8PCJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C403570WA
gene id: 237561:CAALFM_C403570WA
uniprot id: P46593
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: As a major cell surface protein expressed during infection, HWP1 detection can be used for diagnosis of invasive candidiasis. HWP1 epitopes can also be used to develop vaccines for protection against candidiasis.
messages: Belongs to the HWP1 family.
messages: Found in hyphal but not yeast forms.
messages: Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.
messages: Membrane
messages: N- and O-glycosylated.
messages: Reduces the overall mating frequency in both liquid and solid media. Impairs stable attachments to human buccal epithelial cells and reduces capacity to cause systemic candidiasis in mice. Produces a thin biofilm that lacks much of the hyphal mass found in the wild type cell.
messages: Serves as a substrate for mammalian transglutaminases which are necessary for cross-linking between HWP1 and host epithelial cells. Also predicted to be a substrate for cleavage by KEX2.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: The promoter contains a 368 bp region, the HWP1 control region (HCR), which is target of transcription factors and is critical for activation under hypha-inducing conditions. Expression is positively regulated by BCR1, EFG1, FLO8, GPA2, GPR1, MSS11, RBF1, and RFG1; and negatively regulated by NRG1 and TUP1. Transcription is induced in an adhesion-dependent manner and in presence of human serum or hemoglobin. Expression is down-regulated by hypoxic conditions, allicine, ethylenediaminetetra-acetic acid (EDTA), farnesol, linalool, riccardin D, purpurin, filastatin, phorbasin H, Ocimum sanctum essential oil (OSEO), as well as many substances belonging to chemical classes such as methyl aryl-oxazoline carboxylates, dihydrobenzo-d-isoxazolones, and thiazolo-4,5-e-benzoisoxazoles. Moreover, the competitors Saccharomyces boulardii or Streptococcus mutans secrete respectively capric acid and trans-2-decenoic acid (SDSF) which also suppress HWP1 expression.
messages: cell wall

237561:CAALFM C102160WA
gene id: 237561:CAALFM_C102160WA
uniprot id: Q59VY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

237561:CAALFM C107850CA
gene id: 237561:CAALFM_C107850CA
uniprot id: A0A1D8PE86
names: Similarity
messages: Belongs to the APC10 family.

237561:CAALFM C305020WA
gene id: 237561:CAALFM_C305020WA
uniprot id: Q5AND1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTC6 family.
messages: May be involved in telomere capping.
messages: Membrane

237561:CAALFM C112010CA
gene id: 237561:CAALFM_C112010CA
uniprot id: Q5A3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

237561:CAALFM C300450CA
gene id: 237561:CAALFM_C300450CA
uniprot id: Q5A7P6
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

237561:CAALFM C108130CA
gene id: 237561:CAALFM_C108130CA
uniprot id: A0A1D8PEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

237561:CAALFM C600850WA
gene id: 237561:CAALFM_C600850WA
uniprot id: Q59WW7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

237561:CAALFM CR00460CA
gene id: 237561:CAALFM_CR00460CA
uniprot id: A0A1D8PRP4
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

237561:CAALFM C601140CA
gene id: 237561:CAALFM_C601140CA
uniprot id: Q59WT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

237561:CAALFM C502860CA
gene id: 237561:CAALFM_C502860CA
uniprot id: P83775
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
messages: Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

237561:CAALFM C101590CA
gene id: 237561:CAALFM_C101590CA
uniprot id: Q5A8Y5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

237561:CAALFM C113800CA
gene id: 237561:CAALFM_C113800CA
uniprot id: Q5AKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM C601550CA
gene id: 237561:CAALFM_C601550CA
uniprot id: A0A1D8PPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: Mitochondrion

237561:CAALFM C704260WA
gene id: 237561:CAALFM_C704260WA
uniprot id: A0A1D8PRL2
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C105630CA
gene id: 237561:CAALFM_C105630CA
uniprot id: A0A1D8PDL7
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C503920CA
gene id: 237561:CAALFM_C503920CA
uniprot id: Q59MK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

237561:CAALFM C402250CA
gene id: 237561:CAALFM_C402250CA
uniprot id: Q5AMT2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: Cell wall glucan 1,3-beta-glucosidase involved in cell wall biosynthesis and virulence. Crucial for delivery of beta-1,3-glucan to the biofilm matrix and for accumulation of mature matrix biomass. Plays a role as a major antigen in human systemic candidiasis patients.
messages: Cytoplasm
messages: Exhibits diminished extracellular biofilm material, renders cells more dependent on chitin for wall integrity, and attenuates virulence in mice.
messages: Induced during biofilm formation and by fluconazole and micafungin. Expression is also regulated by RCK2.
messages: cell wall

237561:CAALFM C402060CA
gene id: 237561:CAALFM_C402060CA
uniprot id: Q5AMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

237561:CAALFM CR05790CA
gene id: 237561:CAALFM_CR05790CA
uniprot id: A0A1D8PT27
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

237561:CAALFM CR09690CA
gene id: 237561:CAALFM_CR09690CA
uniprot id: A0A1D8PU17
names: Similarity
messages: Belongs to the lysophospholipase family.

237561:CAALFM C304300CA
gene id: 237561:CAALFM_C304300CA
uniprot id: A0A1D8PK28
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

237561:CAALFM C205410WA
gene id: 237561:CAALFM_C205410WA
uniprot id: A0A1D8PHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C101050CA
gene id: 237561:CAALFM_C101050CA
uniprot id: A0A1D8PCD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

237561:CAALFM C404100CA
gene id: 237561:CAALFM_C404100CA
uniprot id: A0A1D8PLZ5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C301880WA
gene id: 237561:CAALFM_C301880WA
uniprot id: Q5AJD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

237561:CAALFM C113950CA
gene id: 237561:CAALFM_C113950CA
uniprot id: Q5AKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Preautophagosomal structure membrane
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

237561:CAALFM C300220WA
gene id: 237561:CAALFM_C300220WA
uniprot id: Q5A7L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR08340WA
gene id: 237561:CAALFM_CR08340WA
uniprot id: Q5A362
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

237561:CAALFM C102840WA
gene id: 237561:CAALFM_C102840WA
uniprot id: A0A1D8PCV9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

237561:CAALFM C602030CA
gene id: 237561:CAALFM_C602030CA
uniprot id: Q59M69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

237561:CAALFM C406840WA
gene id: 237561:CAALFM_C406840WA
uniprot id: A0A1D8PMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

237561:CAALFM C201600CA
gene id: 237561:CAALFM_C201600CA
uniprot id: Q5ALV8
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

237561:CAALFM C400030CA
gene id: 237561:CAALFM_C400030CA
uniprot id: A0A1D8PKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Nucleus

237561:CAALFM C402900CA
gene id: 237561:CAALFM_C402900CA
uniprot id: Q5AFA2
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.
messages: Expressed in cell walls of both yeast and hyphae cells. Up-regulated by growth in hypoxic conditions, during cell wall regeneration, by heat stress, as well as by calcineurin, caspofungin, and fluconazole. Expression is also regulated by CAS5, RLM1, and SPF1.
messages: Extracellular glycosidase which plays an important role in fungal pathogenesis. Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells.
messages: Leads to increased susceptibility to cell wall-perturbing agents.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C400700CA
gene id: 237561:CAALFM_C400700CA
uniprot id: Q59SK0
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

237561:CAALFM C200240CA
gene id: 237561:CAALFM_C200240CA
uniprot id: Q5ACV9
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Membrane
messages: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: Unlike SOD4 and SOD5, SOD6 is not regulated during yeast to hyphae transition or by temperature. Up-regulated during biofilm formation and expression is controlled by HAP43.
messages: cell wall

237561:CAALFM C106510CA
gene id: 237561:CAALFM_C106510CA
uniprot id: Q5AAP8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404480CA
gene id: 237561:CAALFM_C404480CA
uniprot id: A0A1D8PM35
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

237561:CAALFM C700890CA
gene id: 237561:CAALFM_C700890CA
uniprot id: Q5AFP3
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Expression is high in white-phase cells and low in opaque-phase cells.
messages: Interacts with AHR1.
messages: Nucleus
messages: Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase-specific gene expression.

237561:CAALFM C700990WA
gene id: 237561:CAALFM_C700990WA
uniprot id: A0A1D8PQS0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.

237561:CAALFM C202500WA
gene id: 237561:CAALFM_C202500WA
uniprot id: A0A1D8PGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

237561:CAALFM C102360CA
gene id: 237561:CAALFM_C102360CA
uniprot id: Q59VW6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Expression is very weak and pH-independent.
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly (By similarity).

237561:CAALFM C208190WA
gene id: 237561:CAALFM_C208190WA
uniprot id: Q5A2U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

237561:CAALFM C107960WA
gene id: 237561:CAALFM_C107960WA
uniprot id: A0A1D8PE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C1D family.
messages: Nucleus
messages: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.

237561:CAALFM C301490WA
gene id: 237561:CAALFM_C301490WA
uniprot id: Q5AJ93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS7A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C405190CA
gene id: 237561:CAALFM_C405190CA
uniprot id: A0A1D8PM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

237561:CAALFM CR07630CA
gene id: 237561:CAALFM_CR07630CA
uniprot id: A0A1D8PTI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C602710CA
gene id: 237561:CAALFM_C602710CA
uniprot id: Q5AC08
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae and true hyphae. Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers.
messages: Inhibited by pepstatin A analogs.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Activates host systemic immunity and induces host inflammatory cytokine production in a proteolytic activity-independent way. Contributes to corneal pathogenicity. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C107930CA
gene id: 237561:CAALFM_C107930CA
uniprot id: A0A1D8PE66
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504420WA
gene id: 237561:CAALFM_C504420WA
uniprot id: A0A1D8PNY1
names: Similarity
messages: Belongs to the phospholipid scramblase family.

237561:CAALFM C402010CA
gene id: 237561:CAALFM_C402010CA
uniprot id: Q5AMQ4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity.
messages: Golgi apparatus membrane
messages: Results in complete loss of glucosylceramides (GluCers) in mutant cells (PubMed:11443131). Has a decreased hyphal growth rate and increased susceptibility to SDS and fluconazole, suggesting defects in the cell membrane structure (PubMed:20019081). Shows increased resistance to plant defensin RsAFP2, and to heliomicin, a defensin-like peptide from the insect Heliothis virescens (PubMed:14604982).
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

237561:CAALFM C700280WA
gene id: 237561:CAALFM_C700280WA
uniprot id: A0A1D8PQJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C504930CA
gene id: 237561:CAALFM_C504930CA
uniprot id: Q5AK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C307270CA
gene id: 237561:CAALFM_C307270CA
uniprot id: Q5ADS0
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Confers pleiotropic effects like an increased sensitivity to mild heat shock, increased formation of colony morphology variants and induction of hyphal and pseudohypal development (PubMed:12742065). Induces cell cycle defects, as well as sensitivity to thermal, oxidative and cell wall stresses. Rapidly lose viability under starvation conditions (PubMed:21269335).
messages: Cytoplasm
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Nucleus
messages: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Involved in the negative control of switching, as well as in maintaining the yeast cell morphology (PubMed:12742065, PubMed:21269335).
messages: Ubiquitin is encoded by several different genes. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 3 exact head to tail repeats of ubiquitin.

237561:CAALFM CR09120CA
gene id: 237561:CAALFM_CR09120CA
uniprot id: A0A1D8PTV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

237561:CAALFM C600890WA
gene id: 237561:CAALFM_C600890WA
uniprot id: A0A1D8PPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

237561:CAALFM CR07710WA
gene id: 237561:CAALFM_CR07710WA
uniprot id: A0A1D8PTK1
names: Cofactor
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Reduced FMN (FMNH(2)).

237561:CAALFM C205850CA
gene id: 237561:CAALFM_C205850CA
uniprot id: Q59MF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
messages: Belongs to the COG6 family.
messages: Golgi apparatus membrane

237561:CAALFM C206810CA
gene id: 237561:CAALFM_C206810CA
uniprot id: A0A1D8PHW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C602430WA
gene id: 237561:CAALFM_C602430WA
uniprot id: A0A1D8PPV9
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR04130CA
gene id: 237561:CAALFM_CR04130CA
uniprot id: Q5A6Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

237561:CAALFM C209510CA
gene id: 237561:CAALFM_C209510CA
uniprot id: Q59YC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C102030CA
gene id: 237561:CAALFM_C102030CA
uniprot id: Q59TA9
names: Similarity
messages: Belongs to the cytochrome b5 family.

237561:CAALFM C204530WA
gene id: 237561:CAALFM_C204530WA
uniprot id: Q59TD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C107710CA
gene id: 237561:CAALFM_C107710CA
uniprot id: A0A1D8PE37
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

237561:CAALFM C109860CA
gene id: 237561:CAALFM_C109860CA
uniprot id: Q5APB4
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.

237561:CAALFM C700950WA
gene id: 237561:CAALFM_C700950WA
uniprot id: A0A1D8PQQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

237561:CAALFM CR00130CA
gene id: 237561:CAALFM_CR00130CA
uniprot id: A0A1D8PRL8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C209490WA
gene id: 237561:CAALFM_C209490WA
uniprot id: A0A1D8PIG2
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

237561:CAALFM C104890WA
gene id: 237561:CAALFM_C104890WA
uniprot id: A0A1D8PDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

237561:CAALFM C500500WA
gene id: 237561:CAALFM_C500500WA
uniprot id: Q5A507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

237561:CAALFM C303200CA
gene id: 237561:CAALFM_C303200CA
uniprot id: A0A1D8PJN7
names: Similarity
messages: Belongs to the glutaredoxin family.

237561:CAALFM C210080WA
gene id: 237561:CAALFM_C210080WA
uniprot id: A0A1D8PIK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
messages: Nucleus
messages: telomere

237561:CAALFM C113980CA
gene id: 237561:CAALFM_C113980CA
uniprot id: A0A1D8PFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM C206670CA
gene id: 237561:CAALFM_C206670CA
uniprot id: Q59KM8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Bud neck
messages: Cell cycle-regulated with a peak during M/G1.
messages: Leads to inviable cells.
messages: Nucleus
messages: Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis.
messages: spindle
messages: spindle pole body

237561:CAALFM C703330CA
gene id: 237561:CAALFM_C703330CA
uniprot id: A0A1D8PRB3
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

237561:CAALFM C401850CA
gene id: 237561:CAALFM_C401850CA
uniprot id: A0A1D8PLD6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

237561:CAALFM CR10280WA
gene id: 237561:CAALFM_CR10280WA
uniprot id: A0A1D8PU62
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

237561:CAALFM C101090CA
gene id: 237561:CAALFM_C101090CA
uniprot id: Q5A937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

237561:CAALFM C109950CA
gene id: 237561:CAALFM_C109950CA
uniprot id: Q5APA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.

237561:CAALFM C111760CA
gene id: 237561:CAALFM_C111760CA
uniprot id: A0A1D8PF88
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

237561:CAALFM C406860CA
gene id: 237561:CAALFM_C406860CA
uniprot id: A0A1D8PMQ1
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

237561:CAALFM C405430CA
gene id: 237561:CAALFM_C405430CA
uniprot id: A0A1D8PMB1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease that is able to transport phenylalanine (PubMed:21764911, PubMed:28028545).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545).

237561:CAALFM CR10800CA
gene id: 237561:CAALFM_CR10800CA
uniprot id: A0A1D8PUA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

237561:CAALFM C210810WA
gene id: 237561:CAALFM_C210810WA
uniprot id: Q5A5N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
messages: Nucleus

237561:CAALFM C302430WA
gene id: 237561:CAALFM_C302430WA
uniprot id: A0A1D8PJI6
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

237561:CAALFM C206700WA
gene id: 237561:CAALFM_C206700WA
uniprot id: Q59KV5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

237561:CAALFM C302840WA
gene id: 237561:CAALFM_C302840WA
uniprot id: Q5AEJ3
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

237561:CAALFM C102590CA
gene id: 237561:CAALFM_C102590CA
uniprot id: Q5AIA6
names: Similarity
messages: Belongs to the PdxS/SNZ family.

237561:CAALFM C402440CA
gene id: 237561:CAALFM_C402440CA
uniprot id: A0A1D8PLK7
names: Subcellular Location Annotation
messages: cell wall

237561:CAALFM C704110WA
gene id: 237561:CAALFM_C704110WA
uniprot id: A0A1D8PRI2
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C703450CA
gene id: 237561:CAALFM_C703450CA
uniprot id: Q59PP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Cytoplasm
messages: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity).

237561:CAALFM CR03910CA
gene id: 237561:CAALFM_CR03910CA
uniprot id: A0A1D8PSN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

237561:CAALFM C500420CA
gene id: 237561:CAALFM_C500420CA
uniprot id: Q5A4Z9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

237561:CAALFM C207900WA
gene id: 237561:CAALFM_C207900WA
uniprot id: A0A1D8PI00
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

237561:CAALFM C302190CA
gene id: 237561:CAALFM_C302190CA
uniprot id: Q5AJG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM C302530WA
gene id: 237561:CAALFM_C302530WA
uniprot id: A0A1D8PJJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.

237561:CAALFM C503290CA
gene id: 237561:CAALFM_C503290CA
uniprot id: A0A1D8PNP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

237561:CAALFM C103370WA
gene id: 237561:CAALFM_C103370WA
uniprot id: Q5AI15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C111250WA
gene id: 237561:CAALFM_C111250WA
uniprot id: Q59W48
names: Similarity
messages: Belongs to the MAPRE family.

237561:CAALFM C402120WA
gene id: 237561:CAALFM_C402120WA
uniprot id: Q5AMR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

237561:CAALFM C200200WA
gene id: 237561:CAALFM_C200200WA
uniprot id: A0A1D8PG11
names: Similarity
messages: Belongs to the PRP18 family.

237561:CAALFM C300670CA
gene id: 237561:CAALFM_C300670CA
uniprot id: Q5A7S7
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Forms constitutive pseudohyphae. Impairs ability to damage human epithelial or human endothelial cells in vitro.
messages: Induced during host epithelium infection. Expression is positively regulated by CDC28.
messages: Nucleus
messages: Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence.

237561:CAALFM C209150WA
gene id: 237561:CAALFM_C209150WA
uniprot id: A0A1D8PIF7
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

237561:CAALFM C501690CA
gene id: 237561:CAALFM_C501690CA
uniprot id: Q59YH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

237561:CAALFM C107230WA
gene id: 237561:CAALFM_C107230WA
uniprot id: Q59WC5
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

237561:CAALFM CR06110CA
gene id: 237561:CAALFM_CR06110CA
uniprot id: Q59V88
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFX family.
messages: Induced during biofilm formation.
messages: Nucleus
messages: Transcription factor involved in DNA damage responses, morphogenesis, and virulence.

237561:CAALFM C500620WA
gene id: 237561:CAALFM_C500620WA
uniprot id: Q5A519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
messages: Nucleus
messages: telomere

237561:CAALFM C103610CA
gene id: 237561:CAALFM_C103610CA
uniprot id: Q5AHZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Mitochondrion inner membrane

237561:CAALFM CR09590WA
gene id: 237561:CAALFM_CR09590WA
uniprot id: A0A1D8PU08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

237561:CAALFM CR09170CA
gene id: 237561:CAALFM_CR09170CA
uniprot id: Q5A3Z6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Cell membrane
messages: Leads to enhanced sensitivity to both cysteine and sulfite.
messages: Sulfite efflux pump required for the secretion of sulfite as a reducing agent (By similarity). Plays a role in resistance to neutrophils during infection. Involved in transition to filamentous growth, which is believed to be central to the virulence of this human pathogen.
messages: Up-regulated by cysteine, nitic oxide, and in response to neutrophil phagocytosis. Expression is under the control of GCN2, GCN4 and ZCF2.

237561:CAALFM CR10350CA
gene id: 237561:CAALFM_CR10350CA
uniprot id: A0A1D8PU69
names: Similarity
messages: Belongs to the thioredoxin family.

237561:CAALFM C703970CA
gene id: 237561:CAALFM_C703970CA
uniprot id: A0A1D8PRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

237561:CAALFM C110720CA
gene id: 237561:CAALFM_C110720CA
uniprot id: Q59WF4
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. Promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions.
messages: Belongs to the MNN1/MNT family.
messages: Decreases the ability to extend O-linked, and possibly also N-linked, mannans. Leads to hypersensitivity to cell wall-damaging agents, and to a reduction of cell wall mannosylphosphate. Leads also to resistance to killing by the iron-chelating protein lactoferrin.
messages: Enzyme activity is regulated by iron.
messages: Golgi apparatus membrane

237561:CAALFM C601740CA
gene id: 237561:CAALFM_C601740CA
uniprot id: Q5A4N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

237561:CAALFM C111150WA
gene id: 237561:CAALFM_C111150WA
uniprot id: Q59WK1
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

237561:CAALFM C600460CA
gene id: 237561:CAALFM_C600460CA
uniprot id: A0A1D8PPD8
names: Similarity
messages: Belongs to the multicopper oxidase family.

237561:CAALFM C201040WA
gene id: 237561:CAALFM_C201040WA
uniprot id: A0A1D8PG95
names: Similarity
messages: Belongs to the BLOC1S2 family.

237561:CAALFM CR08480CA
gene id: 237561:CAALFM_CR08480CA
uniprot id: A0A1D8PTR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C306480CA
gene id: 237561:CAALFM_C306480CA
uniprot id: A0A1D8PKH0
names: Similarity
messages: Belongs to the UPF0045 family.

237561:CAALFM C401050CA
gene id: 237561:CAALFM_C401050CA
uniprot id: A0A1D8PL68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL40 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C109460WA
gene id: 237561:CAALFM_C109460WA
uniprot id: A0A1D8PEL1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Expression is up-regulated in response to terbinafine.
messages: Homodimer.
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG12 converts mevalonate into 5-phosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
messages: cytosol

237561:CAALFM C108360CA
gene id: 237561:CAALFM_C108360CA
uniprot id: Q5A747
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

237561:CAALFM C108820CA
gene id: 237561:CAALFM_C108820CA
uniprot id: Q5APM6
names: Similarity
messages: Belongs to the PTH family.

237561:CAALFM CR00760CA
gene id: 237561:CAALFM_CR00760CA
uniprot id: Q5A849
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: Constitutive expression independent of white/opaque switching or mating type locus.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C208970CA
gene id: 237561:CAALFM_C208970CA
uniprot id: A0A1D8PIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

237561:CAALFM C405960WA
gene id: 237561:CAALFM_C405960WA
uniprot id: A0A1D8PMG0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

237561:CAALFM C302540CA
gene id: 237561:CAALFM_C302540CA
uniprot id: Q5AEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: May be involved in protection from oxidative damage.
messages: Mitochondrion

237561:CAALFM C704020CA
gene id: 237561:CAALFM_C704020CA
uniprot id: A0A1D8PRH6
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C105460WA
gene id: 237561:CAALFM_C105460WA
uniprot id: Q5A2C3
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

237561:CAALFM C101570CA
gene id: 237561:CAALFM_C101570CA
uniprot id: Q5A8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

237561:CAALFM C406980WA
gene id: 237561:CAALFM_C406980WA
uniprot id: P87020
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZPS1 family.
messages: Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
messages: Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1. Interacts with host Integrin alpha-M/beta-2 heterodimer. Binds also human factor H (CFH), CFHR1, plasminogen (PLG), complement C3, and C4BPA.
messages: Differentially expressed in response to changes in the pH with aximal expression at neutral pH and no expression detected below pH 6.0. Expression is controlled by RIM101. Expression is also increased during adhesion onto human epithelia.
messages: Impairs hypha formation. Protects the fungus against leukocyte killing in vitro and in vivo, impedes the innate immune response to the infection, and increases fungal virulence and organ invasion in vivo.
messages: N- and O-glycosylated. The N- and 0-glycosidically linked carbohydrates represent 18 to 20 percent and 3 to 4 percent, respectively, of the molecular mass of PRA1. 0-linked sugar residues may be involved in the interaction with fibrinogen. Contributes highly to the carbohydrate component of the matrix. Treatment with tunicamycin impairs glycosylation.
messages: Secreted

237561:CAALFM CR01000CA
gene id: 237561:CAALFM_CR01000CA
uniprot id: Q5A872
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.
messages: Impairs the hyphal formation and attenuates the virulence in a mouse systemic candidiasis model.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-515 (H1) in the histidine kinase domain (transmitter domain) to Asp-1300 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two SLN1 molecules, rather than intramolecularly (By similarity).

237561:CAALFM C102790WA
gene id: 237561:CAALFM_C102790WA
uniprot id: Q5AI86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

237561:CAALFM C201490CA
gene id: 237561:CAALFM_C201490CA
uniprot id: A0A1D8PGC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

237561:CAALFM C100890WA
gene id: 237561:CAALFM_C100890WA
uniprot id: Q5ABR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

237561:CAALFM C500110CA
gene id: 237561:CAALFM_C500110CA
uniprot id: A0A1D8PMV9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C400620CA
gene id: 237561:CAALFM_C400620CA
uniprot id: Q59SJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C105360CA
gene id: 237561:CAALFM_C105360CA
uniprot id: Q5A2B2
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

237561:CAALFM C601150WA
gene id: 237561:CAALFM_C601150WA
uniprot id: A0A1D8PPK6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

237561:CAALFM C208270CA
gene id: 237561:CAALFM_C208270CA
uniprot id: A0A1D8PI35
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C202840CA
gene id: 237561:CAALFM_C202840CA
uniprot id: Q5A0J0
names: Similarity
messages: Belongs to the UPF0507 family.

237561:CAALFM C600480CA
gene id: 237561:CAALFM_C600480CA
uniprot id: A0A1D8PPE2
names: Similarity
messages: Belongs to the multicopper oxidase family.

237561:CAALFM C209400CA
gene id: 237561:CAALFM_C209400CA
uniprot id: A0A1D8PIC7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: C-14 sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:11897574). ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol (PubMed:11897574). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction o…
messages: Endoplasmic reticulum membrane
messages: Leads to the accumulation of ignosterol (ergosta-8,14-dienol), and of a new sterol, ergosta-8,14,22-trienol (PubMed:11897574). Results in slow growth and significant increased sensitivity to an allylamine antifungal and to selected cellular inhibitors including cycloheximide, cerulenin, fluphenazine, and brefeldin A (PubMed:11897574). Slightly increases resistance to azoles (PubMed:11897574). Significantly reduces pathogenicity in a mouse model system and fails to produce germ tubes upon incubation in human serum (PubMed:11897574).

237561:CAALFM C111360WA
gene id: 237561:CAALFM_C111360WA
uniprot id: A0A1D8PF45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR04730WA
gene id: 237561:CAALFM_CR04730WA
uniprot id: A0A1D8PST6
names: Similarity
messages: Belongs to the TMEM14 family.

237561:CAALFM C502760WA
gene id: 237561:CAALFM_C502760WA
uniprot id: A0A1D8PNI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

237561:CAALFM CR10510WA
gene id: 237561:CAALFM_CR10510WA
uniprot id: Q5ACL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat RTC1 family.
messages: May be involved in a process influencing telomere capping.
messages: Vacuole

237561:CAALFM CR09740WA
gene id: 237561:CAALFM_CR09740WA
uniprot id: Q5ACU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Interacts with the SSU processome.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM CR08020CA
gene id: 237561:CAALFM_CR08020CA
uniprot id: A0A1D8PTN4
names: Similarity
messages: Belongs to the NOP10 family.

237561:CAALFM C300600WA
gene id: 237561:CAALFM_C300600WA
uniprot id: Q5A7R7
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: IFF11 differs from other HYR1/IFF family members in lacking a GPI-anchor.
messages: Leads to hypersensitivity to cell wall-damaging agents and highly attenuated in a murine model of systemic infection.
messages: O-glycosylated.
messages: Repressed by HAP43.
messages: cell wall

237561:CAALFM CR05670CA
gene id: 237561:CAALFM_CR05670CA
uniprot id: Q59PR9
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Nucleus
messages: Repressed hyphae and in biofilm.
messages: Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth.

237561:CAALFM C112820CA
gene id: 237561:CAALFM_C112820CA
uniprot id: A0A1D8PFJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

237561:CAALFM C401830CA
gene id: 237561:CAALFM_C401830CA
uniprot id: A0A1D8PLD9
names: Similarity
messages: Belongs to the peptidase M20A family.

237561:CAALFM C504740CA
gene id: 237561:CAALFM_C504740CA
uniprot id: Q5AK60
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

237561:CAALFM C502600WA
gene id: 237561:CAALFM_C502600WA
uniprot id: A0A1D8PNH4
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

237561:CAALFM C204040CA
gene id: 237561:CAALFM_C204040CA
uniprot id: A0A1D8PH14
names: Similarity
messages: Belongs to the DOCK family.

237561:CAALFM C601760WA
gene id: 237561:CAALFM_C601760WA
uniprot id: A0A1D8PPP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

237561:CAALFM C302590WA
gene id: 237561:CAALFM_C302590WA
uniprot id: A0A1D8PJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

237561:CAALFM C210030CA
gene id: 237561:CAALFM_C210030CA
uniprot id: Q59XX2
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 17 family.
messages: Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1.
messages: Expressed predominantly by the mycelial cells. Also induced during cell wall regeneration and biofilm formation. Repressed by fluconazole.
messages: Glycosylated protein with a polysaccharide moiety composed exclusively of mannose and glucose at a ratio of 12.7 to 1. Contributes highly to the carbohydrate component of the matrix. Treatment with tunicamycin impairs glycosylation.
messages: Impairs germ tube formation and suppresses hyphal formation. Decreases also pathogenicity and adherence to polystyrene plates.
messages: Surface mannoprotein required for hyphal morphogenesis, surface adherence, and pathogenicity. Contributes in a high proportion to the carbohydrate component of the matrix due to high levels of glycosylation and may play important roles during biofilm development and maintenance. Acts as a major antigen target of host cell-mediated immune response. Induces extensive T-cell proliferation of human peripheral blood mononuclear cells. Facilitates host dendritic cells maturation and promotes cytokine production through its glycosylated portion while its protein core is essentially involved in induction of T-cell response.
messages: The presence of the MP65 gene can be used as a diagnostic marker to distinguish C.albicans from other yeast or Candida species by PCR.
messages: cell wall

237561:CAALFM C302440CA
gene id: 237561:CAALFM_C302440CA
uniprot id: Q5AEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C604540CA
gene id: 237561:CAALFM_C604540CA
uniprot id: Q59RH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing.

237561:CAALFM C201130WA
gene id: 237561:CAALFM_C201130WA
uniprot id: Q5AD56
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Required for yeast cell adherence to silicone substrate, but nor required not required for buccal epithelial cell adherence or virulence in mouse systemic infection.
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the NOT protein complex.
messages: Cytoplasm
messages: Decreases cell adherence to silicone substrate. Decreases slightly filamentation.
messages: Nucleus

237561:CAALFM C702320WA
gene id: 237561:CAALFM_C702320WA
uniprot id: Q5AH58
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

237561:CAALFM C103210CA
gene id: 237561:CAALFM_C103210CA
uniprot id: A0A1D8PCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

237561:CAALFM C703590CA
gene id: 237561:CAALFM_C703590CA
uniprot id: Q59R29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

237561:CAALFM C402700WA
gene id: 237561:CAALFM_C402700WA
uniprot id: Q5AF80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

237561:CAALFM CR09360WA
gene id: 237561:CAALFM_CR09360WA
uniprot id: A0A1D8PTX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

237561:CAALFM CR07060CA
gene id: 237561:CAALFM_CR07060CA
uniprot id: Q59SN6
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate. Blocks biofilm formation.
messages: Expression is down-regulated during growth at pH 8 by the pH-responsive transcription factor RIM101. Induced during exposure to the weak acid stress of acetic acid, through the regulation by the transcription factor MNL1.
messages: Nucleus
messages: Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation.

237561:CAALFM CR04620CA
gene id: 237561:CAALFM_CR04620CA
uniprot id: A0A1D8PST5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C602910WA
gene id: 237561:CAALFM_C602910WA
uniprot id: A0A1D8PQ05
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

237561:CAALFM C110710CA
gene id: 237561:CAALFM_C110710CA
uniprot id: Q59WF2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C502480WA
gene id: 237561:CAALFM_C502480WA
uniprot id: Q5AGC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus
messages: Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.

237561:CAALFM C208160CA
gene id: 237561:CAALFM_C208160CA
uniprot id: A0A1D8PI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM CR07820WA
gene id: 237561:CAALFM_CR07820WA
uniprot id: A0A1D8PTL1
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

237561:CAALFM C303840CA
gene id: 237561:CAALFM_C303840CA
uniprot id: Q59ST8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.
messages: May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

237561:CAALFM C304950WA
gene id: 237561:CAALFM_C304950WA
uniprot id: Q5AND9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

237561:CAALFM CR03820CA
gene id: 237561:CAALFM_CR03820CA
uniprot id: A0A1D8PSK4
names: Similarity
messages: Belongs to the peptidase C48 family.

237561:CAALFM C503250WA
gene id: 237561:CAALFM_C503250WA
uniprot id: A0A1D8PNN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.

237561:CAALFM C303660WA
gene id: 237561:CAALFM_C303660WA
uniprot id: Q59SR6
names: Function
names: Similarity
messages: Belongs to the IRS4 family.
messages: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).

237561:CAALFM C200660CA
gene id: 237561:CAALFM_C200660CA
uniprot id: Q5AD05
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Induced by farnesol and ciclopirox. Expression is higher in opaque cells compared to white cells.
messages: Membrane
messages: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR02610CA
gene id: 237561:CAALFM_CR02610CA
uniprot id: A0A1D8PS91
names: Subcellular Location Annotation
messages: Nucleus membrane

237561:CAALFM C504880CA
gene id: 237561:CAALFM_C504880CA
uniprot id: Q5AK46
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C112050WA
gene id: 237561:CAALFM_C112050WA
uniprot id: Q5A3L0
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

237561:CAALFM C402020WA
gene id: 237561:CAALFM_C402020WA
uniprot id: Q5AMQ5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

237561:CAALFM CR06780WA
gene id: 237561:CAALFM_CR06780WA
uniprot id: A0A1D8PTA8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C400610WA
gene id: 237561:CAALFM_C400610WA
uniprot id: A0A1D8PL48
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C601440CA
gene id: 237561:CAALFM_C601440CA
uniprot id: A0A1D8PPM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C210050WA
gene id: 237561:CAALFM_C210050WA
uniprot id: A0A1D8PIM4
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C501200WA
gene id: 237561:CAALFM_C501200WA
uniprot id: Q5A1V3
names: Function
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.

237561:CAALFM CR07010WA
gene id: 237561:CAALFM_CR07010WA
uniprot id: Q59SM8
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

237561:CAALFM C300110CA
gene id: 237561:CAALFM_C300110CA
uniprot id: Q5A7K3
names: Similarity
messages: Belongs to the SEC6 family.

237561:CAALFM C404280CA
gene id: 237561:CAALFM_C404280CA
uniprot id: Q59P96
names: Function
names: Similarity
messages: Belongs to the IRC6 family.
messages: Involved in gross chromosomal rearrangements (GCRs) and telomere healing.

237561:CAALFM C200330CA
gene id: 237561:CAALFM_C200330CA
uniprot id: Q5ACW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

237561:CAALFM C203410WA
gene id: 237561:CAALFM_C203410WA
uniprot id: A0A1D8PGX7
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C210760CA
gene id: 237561:CAALFM_C210760CA
uniprot id: Q5A5P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

237561:CAALFM C107580CA
gene id: 237561:CAALFM_C107580CA
uniprot id: Q59PV6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Expression is specific to in opaque cells, in presence of lactate, and during hyphal growth. Expression is repressed in response to alpha pheromone.
messages: Secreted
messages: Secreted protein that acts as a virulence factor during infections.

237561:CAALFM C302290WA
gene id: 237561:CAALFM_C302290WA
uniprot id: A0A1D8PJF1
names: Similarity
messages: Belongs to the RMD1/sif2 family.

237561:CAALFM C602190CA
gene id: 237561:CAALFM_C602190CA
uniprot id: Q59S81
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

237561:CAALFM CR02810WA
gene id: 237561:CAALFM_CR02810WA
uniprot id: A0A1D8PSB5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR05990CA
gene id: 237561:CAALFM_CR05990CA
uniprot id: Q5A287
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Enhances flocculation, filamentous growth, and hypha-specific gene expression in several media and at several growth temperatures.
messages: Nucleus
messages: Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia.

237561:CAALFM CR07330WA
gene id: 237561:CAALFM_CR07330WA
uniprot id: A0A1D8PTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

237561:CAALFM C406110CA
gene id: 237561:CAALFM_C406110CA
uniprot id: A0A1D8PMH6
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

237561:CAALFM C203810CA
gene id: 237561:CAALFM_C203810CA
uniprot id: A0A1D8PGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL21 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C502710WA
gene id: 237561:CAALFM_C502710WA
uniprot id: Q5AG89
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

237561:CAALFM C305570WA
gene id: 237561:CAALFM_C305570WA
uniprot id: Q59YT1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Leads to defects in biofilm architecture and attenuated virulence.
messages: MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.

237561:CAALFM C104190CA
gene id: 237561:CAALFM_C104190CA
uniprot id: Q59VP0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Lacks the C-terminal half of the classical GPI inositol-deacylases.

237561:CAALFM CR03230WA
gene id: 237561:CAALFM_CR03230WA
uniprot id: Q59UG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: May be involved in splicing.
messages: Nucleus

237561:CAALFM C101450WA
gene id: 237561:CAALFM_C101450WA
uniprot id: A0A1D8PCI9
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

237561:CAALFM C701670WA
gene id: 237561:CAALFM_C701670WA
uniprot id: Q5AGY1
names: Similarity
messages: Belongs to the amidase family.

237561:CAALFM C400410WA
gene id: 237561:CAALFM_C400410WA
uniprot id: Q59UQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

237561:CAALFM C209910CA
gene id: 237561:CAALFM_C209910CA
uniprot id: A0A1D8PIL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM CR01620CA
gene id: 237561:CAALFM_CR01620CA
uniprot id: P82610
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Inhibited weakly by methotrexate.

237561:CAALFM C701180WA
gene id: 237561:CAALFM_C701180WA
uniprot id: Q59S52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

237561:CAALFM C304380CA
gene id: 237561:CAALFM_C304380CA
uniprot id: Q5ANL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).
messages: Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA (By similarity).
messages: nucleolus

237561:CAALFM CR03340CA
gene id: 237561:CAALFM_CR03340CA
uniprot id: Q59UH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Cytoplasm
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
messages: Nucleus

237561:CAALFM C700330CA
gene id: 237561:CAALFM_C700330CA
uniprot id: A0A1D8PQL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

237561:CAALFM C300100WA
gene id: 237561:CAALFM_C300100WA
uniprot id: Q5A7K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.

237561:CAALFM C400140CA
gene id: 237561:CAALFM_C400140CA
uniprot id: A0A1D8PKY7
names: Similarity
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

237561:CAALFM C106890CA
gene id: 237561:CAALFM_C106890CA
uniprot id: A0A1D8PDZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL34 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C602270CA
gene id: 237561:CAALFM_C602270CA
uniprot id: Q59S72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).

237561:CAALFM C604160CA
gene id: 237561:CAALFM_C604160CA
uniprot id: Q59KF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.
messages: Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM C202850WA
gene id: 237561:CAALFM_C202850WA
uniprot id: A0A1D8PGQ6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504290CA
gene id: 237561:CAALFM_C504290CA
uniprot id: A0A1D8PNX8
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

237561:CAALFM C200820WA
gene id: 237561:CAALFM_C200820WA
uniprot id: A0A1D8PG79
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

237561:CAALFM C704010WA
gene id: 237561:CAALFM_C704010WA
uniprot id: A0A1D8PRH1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

237561:CAALFM CR10660WA
gene id: 237561:CAALFM_CR10660WA
uniprot id: A0A1D8PUA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C702330WA
gene id: 237561:CAALFM_C702330WA
uniprot id: A0A1D8PR42
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C301080WA
gene id: 237561:CAALFM_C301080WA
uniprot id: A0A1D8PJ23
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

237561:CAALFM C105610WA
gene id: 237561:CAALFM_C105610WA
uniprot id: Q5A9Z1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

237561:CAALFM C603230WA
gene id: 237561:CAALFM_C603230WA
uniprot id: Q5ABU0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

237561:CAALFM C106460CA
gene id: 237561:CAALFM_C106460CA
uniprot id: P0CU35
uniprot id: Q96W54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU) (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (Probable).
messages: Cytoplasm

237561:CAALFM C406370CA
gene id: 237561:CAALFM_C406370CA
uniprot id: Q5A1C1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C102810WA
gene id: 237561:CAALFM_C102810WA
uniprot id: Q5AI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

237561:CAALFM C107260CA
gene id: 237561:CAALFM_C107260CA
uniprot id: Q59WC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

237561:CAALFM C304520CA
gene id: 237561:CAALFM_C304520CA
uniprot id: Q92210
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

237561:CAALFM C504710WA
gene id: 237561:CAALFM_C504710WA
uniprot id: Q5AK64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

237561:CAALFM C702310CA
gene id: 237561:CAALFM_C702310CA
uniprot id: A0A1D8PR34
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C305800WA
gene id: 237561:CAALFM_C305800WA
uniprot id: A0A1D8PKA3
names: Similarity
messages: Belongs to the SEN54 family.

237561:CAALFM CR09670CA
gene id: 237561:CAALFM_CR09670CA
uniprot id: A0A1D8PU04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

237561:CAALFM C205210WA
gene id: 237561:CAALFM_C205210WA
uniprot id: Q59ZG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD2 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

237561:CAALFM C206020WA
gene id: 237561:CAALFM_C206020WA
uniprot id: A0A1D8PHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

237561:CAALFM C110270CA
gene id: 237561:CAALFM_C110270CA
uniprot id: Q5AP66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.

237561:CAALFM C201720CA
gene id: 237561:CAALFM_C201720CA
uniprot id: Q5ALU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

237561:CAALFM C703860WA
gene id: 237561:CAALFM_C703860WA
uniprot id: A0A1D8PRH0
names: Similarity
messages: Belongs to the peptidase S8 family.

237561:CAALFM C502230WA
gene id: 237561:CAALFM_C502230WA
uniprot id: A0A1D8PNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

237561:CAALFM C102180WA
gene id: 237561:CAALFM_C102180WA
uniprot id: A0A1D8PCM2
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

237561:CAALFM C401870CA
gene id: 237561:CAALFM_C401870CA
uniprot id: A0A1D8PLH0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Expression is regulated by the transcription factor NRG1.
messages: Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:11243736). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

237561:CAALFM C307680WA
gene id: 237561:CAALFM_C307680WA
uniprot id: Q5ADX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
messages: Nucleus

237561:CAALFM C406250CA
gene id: 237561:CAALFM_C406250CA
uniprot id: A0A1D8PMI1
names: Similarity
messages: Belongs to the SEC3 family.

237561:CAALFM C305780CA
gene id: 237561:CAALFM_C305780CA
uniprot id: Q5A4H5
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expression is higher in white cells than opaque cells. Induced during exposure to the weak acid stress of acetic acid, through the regulation by the transcription factor MNL1.
messages: Leads to hypersensitivity to ion stress.
messages: Nucleus
messages: Probably phosphorylated in a calcineurin-dependent manner.
messages: Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance.

237561:CAALFM C307490WA
gene id: 237561:CAALFM_C307490WA
uniprot id: Q5ADV2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

237561:CAALFM C504580CA
gene id: 237561:CAALFM_C504580CA
uniprot id: Q5AK78
names: Similarity
messages: Belongs to the VPS25 family.

237561:CAALFM C404970CA
gene id: 237561:CAALFM_C404970CA
uniprot id: A0A1D8PM81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

237561:CAALFM C200180CA
gene id: 237561:CAALFM_C200180CA
uniprot id: Q5ACV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

237561:CAALFM C209660WA
gene id: 237561:CAALFM_C209660WA
uniprot id: Q59YD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP16 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM C303030CA
gene id: 237561:CAALFM_C303030CA
uniprot id: A0A1D8PJK3
names: Similarity
messages: Belongs to the peptidase M14 family.

237561:CAALFM C502210WA
gene id: 237561:CAALFM_C502210WA
uniprot id: A0A1D8PND7
names: Similarity
messages: Belongs to the GET4 family.

237561:CAALFM CR03100WA
gene id: 237561:CAALFM_CR03100WA
uniprot id: Q59UE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

237561:CAALFM C108320WA
gene id: 237561:CAALFM_C108320WA
uniprot id: Q5A750
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

237561:CAALFM CR00070WA
gene id: 237561:CAALFM_CR00070WA
uniprot id: Q5AAF4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the formin homology family. BNI1 subfamily.
messages: Bud neck
messages: Cell septum
messages: Interacts with IQG1.
messages: Lead to a cell separation defect.
messages: May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth.

237561:CAALFM C404340CA
gene id: 237561:CAALFM_C404340CA
uniprot id: Q59PA3
names: Similarity
messages: Belongs to the frataxin family.

237561:CAALFM C703940CA
gene id: 237561:CAALFM_C703940CA
uniprot id: Q5A0A9
names: Function
names: Induction
names: Similarity
names: Subunit
messages: 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Expressed from S phase through G2 and M phases and is degraded at the end of mitosis. Expression is down-regulated by the anti-fungal agent plagiochin E (PLE).
messages: Interacts with IQG1.

237561:CAALFM C101530CA
gene id: 237561:CAALFM_C101530CA
uniprot id: A0A1D8PCI5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C204350CA
gene id: 237561:CAALFM_C204350CA
uniprot id: Q59TB2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Leads to completely attenuated virulence in a mouse keratitis model.
messages: Mitochondrion matrix
messages: Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity). Required for embedded hyphal growth, for wild-type respiratory growth, and biofilm development. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens. Plays am important role in virulence.

237561:CAALFM C702940CA
gene id: 237561:CAALFM_C702940CA
uniprot id: Q5A5B3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

237561:CAALFM CR02240CA
gene id: 237561:CAALFM_CR02240CA
uniprot id: Q59UZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C102400CA
gene id: 237561:CAALFM_C102400CA
uniprot id: A0A1D8PCR3
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

237561:CAALFM C206240WA
gene id: 237561:CAALFM_C206240WA
uniprot id: A0A1D8PHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

237561:CAALFM CR00320CA
gene id: 237561:CAALFM_CR00320CA
uniprot id: Q5AAI8
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis.
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Bud neck
messages: Bud tip
messages: Component of the GIN4 complex which forms a ring at the bud neck.
messages: Leads to constitutive filamentous growth and abnormalities in both septin localization and organization. Exhibits greatly reduced virulence in a mouse model of systemic candidiasis.
messages: Phosphorylation is cell cycle dependent and is important for its bud neck localization. Phosphorylation is highest in newly collected G1 cells, declines when the cells are traversing through the G1 phase, and reaches the lowest level around the time of bud emergence. Phosphorylation increases and remains high through the rest of the cell cycle until the beginning of the next one, when it decreases again. Phosphorylation involves two septin ring-associated kinases, CLA4 and GIN4, and its dephosphorylation occurs at the septin ring in a manner dependent on the phosphatases PP2A and CDC14.

237561:CAALFM C600470CA
gene id: 237561:CAALFM_C600470CA
uniprot id: A0A1D8PPE6
names: Similarity
messages: Belongs to the multicopper oxidase family.

237561:CAALFM C700610CA
gene id: 237561:CAALFM_C700610CA
uniprot id: A0A1D8PQM8
names: Similarity
messages: Belongs to the RMD1/sif2 family.

237561:CAALFM C405770CA
gene id: 237561:CAALFM_C405770CA
uniprot id: Q5A446
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Ferric reductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Involved in maintenance of cell wall integrity (CWI), mitochondrial function, and interaction between the pathogen and the host.
messages: Leads to abnormal cell wall composition, decreased ability of adhesion, and hypersensitivity to cell wall stresses. Increases mitochondrial activity and shows abnormal mitochondrial morphology. Results also in up-regulation of the expression of the cell wall integrity (CWI) genes PGA13 and CRH11, enhanded secretion, and decreased ability to invade HeLa cells.
messages: Transcription is negatively regulated by SFU1, copper, amphotericin B, and caspofungin; and induced by ciclopirox olamine.

237561:CAALFM CR01040CA
gene id: 237561:CAALFM_CR01040CA
uniprot id: A0A1D8PRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

237561:CAALFM C100900WA
gene id: 237561:CAALFM_C100900WA
uniprot id: A0A1D8PCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

237561:CAALFM CR01260WA
gene id: 237561:CAALFM_CR01260WA
uniprot id: A0A1D8PRX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

237561:CAALFM C203250WA
gene id: 237561:CAALFM_C203250WA
uniprot id: A0A1D8PGU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C402620CA
gene id: 237561:CAALFM_C402620CA
uniprot id: Q5AF71
names: Similarity
messages: Belongs to the FGGY kinase family.

237561:CAALFM CR06690CA
gene id: 237561:CAALFM_CR06690CA
uniprot id: Q59PZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.

237561:CAALFM C101320WA
gene id: 237561:CAALFM_C101320WA
uniprot id: A0A1D8PCG9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR02820WA
gene id: 237561:CAALFM_CR02820WA
uniprot id: A0A1D8PSA9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

237561:CAALFM C401680WA
gene id: 237561:CAALFM_C401680WA
uniprot id: Q5AMM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

237561:CAALFM C403430WA
gene id: 237561:CAALFM_C403430WA
uniprot id: A0A1D8PLT8
names: Similarity
messages: Belongs to the yippee family.

237561:CAALFM C304780CA
gene id: 237561:CAALFM_C304780CA
uniprot id: Q5ANG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

237561:CAALFM C104360CA
gene id: 237561:CAALFM_C104360CA
uniprot id: A0A1D8PD97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Inhibits the enzyme activity of ATPase.
messages: Mitochondrion

237561:CAALFM C201860CA
gene id: 237561:CAALFM_C201860CA
uniprot id: Q5AM80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

237561:CAALFM C200150WA
gene id: 237561:CAALFM_C200150WA
uniprot id: A0A1D8PG00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C603860CA
gene id: 237561:CAALFM_C603860CA
uniprot id: Q5A8I6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C208660CA
gene id: 237561:CAALFM_C208660CA
uniprot id: Q59Y39
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C210850CA
gene id: 237561:CAALFM_C210850CA
uniprot id: Q5A5N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

237561:CAALFM C205710CA
gene id: 237561:CAALFM_C205710CA
uniprot id: A0A1D8PHH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL33 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C109510WA
gene id: 237561:CAALFM_C109510WA
uniprot id: Q5APF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM C205990CA
gene id: 237561:CAALFM_C205990CA
uniprot id: Q59X09
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

237561:CAALFM C300500CA
gene id: 237561:CAALFM_C300500CA
uniprot id: Q5A7Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

237561:CAALFM C701740CA
gene id: 237561:CAALFM_C701740CA
uniprot id: Q5AGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

237561:CAALFM C401890CA
gene id: 237561:CAALFM_C401890CA
uniprot id: Q5AMP3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

237561:CAALFM C600230WA
gene id: 237561:CAALFM_C600230WA
uniprot id: A0A1D8PPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

237561:CAALFM C302040CA
gene id: 237561:CAALFM_C302040CA
uniprot id: Q5AJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LOC1 family.
messages: Component of the 66S pre-ribosomal particle.
messages: Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM C502690WA
gene id: 237561:CAALFM_C502690WA
uniprot id: A0A1D8PNH7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C111900CA
gene id: 237561:CAALFM_C111900CA
uniprot id: Q5A3J3
names: Similarity
messages: Belongs to the RENT3 family.

237561:CAALFM C100620WA
gene id: 237561:CAALFM_C100620WA
uniprot id: Q5ABC6
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOB1/phocein family.
messages: Cytoplasm
messages: Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. The RAM network is critically required for hyphal growth as well as normal vegetative growth, and for polarization of lipid rafts and the actin cytoskeleton. It play an essential role in biofilm formation. The RAM network also plays a role in serum- and antifungal azoles-induced activation of ergosterol biosynthesis genes, especially those involved in the late steps of ergosterol biosynthesis.
messages: Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.
messages: Leads to hypersensitivity to cell-wall- or membrane-perturbing agents, cell-separation defects, a multinucleate phenotype, and loss of cell polarity.
messages: Nucleus
messages: Phosphorylated by CDC28 at Ser-44, Ser-51, Ser-67, and Ser-97. Phosphorylation occurs during bud emergence and is maintained until the G2/M transition. Dephosphorylated at the end of mitosis. Phosphorylation is required for the maintenance of polarisome components in hyphae.

237561:CAALFM C600840WA
gene id: 237561:CAALFM_C600840WA
uniprot id: Q59WW8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

237561:CAALFM C105010CA
gene id: 237561:CAALFM_C105010CA
uniprot id: A0A1D8PDF5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C602360WA
gene id: 237561:CAALFM_C602360WA
uniprot id: A0A1D8PPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

237561:CAALFM C503090WA
gene id: 237561:CAALFM_C503090WA
uniprot id: Q5AG40
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Expression is regulated by GCN2 and GCN4.
messages: Leads to defects in endocytosis. Displays a characteristic class E vacuolar morphology and multilamellar structures consistent with an aberrant prevacuolar compartment. Missorts several vacuolar proteins to the extracellular space, including carboxypeptidase (CPY), vacuolar protease A (PrA), and vacuolar protease B (PrB). In addition, certain soluble secretory proteins, such as invertase and acid phosphatase, are missorted from the pre-vacuolar compartment (PVC) to the general secretory pathway prior to exocytosis. Results also in a decrease of canonically secreted proteins. Shows increased biofilm formation. Causes reduced tissue damage in an in vitro oral epithelial model (OEM) of tissue invasion, and defects in macrophage killing in vitro. Shows also attenuated virulence in an in vivo Caenorhabditis elegans model representative of intestinal epithelial infection.
messages: Monomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant.
messages: Pre-vacuolar protein sorting protein involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Required for extracellular secretion of the secreted aspartyl proteases SAP2, SAP4, SAP5, and SAP6. Its regulation of the pre-vacuolar secretory pathway is critical for virulence.

237561:CAALFM C301190CA
gene id: 237561:CAALFM_C301190CA
uniprot id: A0A1D8PJ57
names: Similarity
messages: Belongs to the RMD1/sif2 family.

237561:CAALFM C301300CA
gene id: 237561:CAALFM_C301300CA
uniprot id: Q5AJ71
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amines and amino acids act as activators of catalytic activity, whereas natural product-based phenols, dithiocarbamates, aliphatic and aromatic carboxylates, boronic acids, and sulfonamides act as inhibitors of enzymatic activity. Also inhibited by anions such as cyanide and carbonate, and to a lesser extent by sulfate, phenylboronic, and phenyl arsonic acid.
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Acts as a CO(2) chemosensor and induces CO(2)-mediated filamentation. Essential for pathological growth in niches where sufficient CO(2) is not supplied by the host. Necessary for white-to-opaque switching at low CO(2) concentrations.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Strongly expressed when cells are grown in ambient air but non-detectable when cultured in air enriched with CO(2). Up-regulated by MNL1, HAP43, RCA1, and during early stages of biofilm development.

237561:CAALFM C204380CA
gene id: 237561:CAALFM_C204380CA
uniprot id: A0A1D8PH56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C301960CA
gene id: 237561:CAALFM_C301960CA
uniprot id: Q5AJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

237561:CAALFM CR06670WA
gene id: 237561:CAALFM_CR06670WA
uniprot id: Q59PZ9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR10630WA
gene id: 237561:CAALFM_CR10630WA
uniprot id: A0A1D8PUA4
names: Similarity
messages: Belongs to the PIH1 family.

237561:CAALFM C501510WA
gene id: 237561:CAALFM_C501510WA
uniprot id: Q59NQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

237561:CAALFM C104400CA
gene id: 237561:CAALFM_C104400CA
uniprot id: Q59KZ1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Inactivated by metal-chelating agents phenanthroline and EDTA. Inhibited by bestatin, an aminopeptidase inhibitor. Not inhibited by pepstatin A and PMSF, inhibitors of aspartic and the serine proteases, respectively. Not inhibited by carboxypeptidase inhibitor.
messages: Metalloprotease that specifically hydrolyzes peptides with N-terminal alanine, arginine and leucine residues.
messages: cell wall

237561:CAALFM C110080WA
gene id: 237561:CAALFM_C110080WA
uniprot id: Q5AP89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
messages: Nucleus

237561:CAALFM C204210WA
gene id: 237561:CAALFM_C204210WA
uniprot id: A0A1D8PH43
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

237561:CAALFM C207880WA
gene id: 237561:CAALFM_C207880WA
uniprot id: Q5A2L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Membrane

237561:CAALFM C107050CA
gene id: 237561:CAALFM_C107050CA
uniprot id: Q5AAW1
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

237561:CAALFM C108080CA
gene id: 237561:CAALFM_C108080CA
uniprot id: A0A1D8PE69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

237561:CAALFM C114400CA
gene id: 237561:CAALFM_C114400CA
uniprot id: A0A1D8PFX1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

237561:CAALFM CR04800WA
gene id: 237561:CAALFM_CR04800WA
uniprot id: Q59MZ9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).
messages: induced in low iron conditions.

237561:CAALFM CR04610CA
gene id: 237561:CAALFM_CR04610CA
uniprot id: Q5A6K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: May be required for lysis of autophagic vesicles after delivery to the vacuole.
messages: Vacuole membrane

237561:CAALFM C703560WA
gene id: 237561:CAALFM_C703560WA
uniprot id: Q59R32
names: Disruption Phenotype
names: Function
names: Induction
messages: Expression is induced during infection and decreased by benomyl treatment.
messages: Leads to strong defects in host cell damage in a model of human oral epithelial cells. Exhibits reduced survival following co-incubation with a human macrophage cell line and causes more severe kidney pathology following intravenous murine infection. Leads also to higher levels of interleukin-1 beta (IL1B), following incubation with murine macrophages.
messages: Virulence factor involved in pathogen-host interaction. Modulates host pro-inflammatory cytokine interleukin-1 beta (IL1B) expression.

237561:CAALFM CR01490CA
gene id: 237561:CAALFM_CR01490CA
uniprot id: A0A1D8PRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

237561:CAALFM C500730WA
gene id: 237561:CAALFM_C500730WA
uniprot id: Q59XA7
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Induced in high iron conditions.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C704190CA
gene id: 237561:CAALFM_C704190CA
uniprot id: A0A1D8PRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

237561:CAALFM C208040CA
gene id: 237561:CAALFM_C208040CA
uniprot id: A0A1D8PI15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C210210CA
gene id: 237561:CAALFM_C210210CA
uniprot id: Q59XU5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity).

237561:CAALFM C305610WA
gene id: 237561:CAALFM_C305610WA
uniprot id: Q59YS7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Induced during biofilm formation.
messages: Leads to small cell wall defects but displays a severe attenuation of virulence in a murine infection model.
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Involved in virulence.

237561:CAALFM C101920WA
gene id: 237561:CAALFM_C101920WA
uniprot id: A0A1D8PCM6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C210770WA
gene id: 237561:CAALFM_C210770WA
uniprot id: Q5A5N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

237561:CAALFM C302320WA
gene id: 237561:CAALFM_C302320WA
uniprot id: A0A1D8PJF9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

237561:CAALFM C501620CA
gene id: 237561:CAALFM_C501620CA
uniprot id: Q59N31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

237561:CAALFM C301400WA
gene id: 237561:CAALFM_C301400WA
uniprot id: Q5AJ82
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the END3 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: Regulated by GCN4 and induced in response to amino acid starvation.
messages: actin patch

237561:CAALFM C500560WA
gene id: 237561:CAALFM_C500560WA
uniprot id: Q5A513
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C100320WA
gene id: 237561:CAALFM_C100320WA
uniprot id: Q5AB94
names: Similarity
messages: Belongs to the VPS29 family.

237561:CAALFM C105860WA
gene id: 237561:CAALFM_C105860WA
uniprot id: Q5AA21
names: Similarity
messages: Belongs to the pirin family.

237561:CAALFM C206280CA
gene id: 237561:CAALFM_C206280CA
uniprot id: A0A1D8PHN4
names: Similarity
messages: Belongs to the ADIP family.

237561:CAALFM C302080WA
gene id: 237561:CAALFM_C302080WA
uniprot id: A0A1D8PJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C402360WA
gene id: 237561:CAALFM_C402360WA
uniprot id: Q5AF38
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

237561:CAALFM C300340WA
gene id: 237561:CAALFM_C300340WA
uniprot id: Q5A7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

237561:CAALFM CR03650WA
gene id: 237561:CAALFM_CR03650WA
uniprot id: A0A1D8PSJ3
names: Similarity
messages: Belongs to the CWC22 family.

237561:CAALFM C405760WA
gene id: 237561:CAALFM_C405760WA
uniprot id: A0A1D8PME6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

237561:CAALFM C100380CA
gene id: 237561:CAALFM_C100380CA
uniprot id: Q5AB99
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

237561:CAALFM C301950CA
gene id: 237561:CAALFM_C301950CA
uniprot id: Q5AJD8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C101650WA
gene id: 237561:CAALFM_C101650WA
uniprot id: Q5A8X9
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

237561:CAALFM CR02760CA
gene id: 237561:CAALFM_CR02760CA
uniprot id: A0A1D8PSA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

237561:CAALFM C501180WA
gene id: 237561:CAALFM_C501180WA
uniprot id: A0A1D8PN62
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

237561:CAALFM CR10190CA
gene id: 237561:CAALFM_CR10190CA
uniprot id: A0A1D8PU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: centrosome
messages: sarcomere
messages: stress fiber

237561:CAALFM C109170WA
gene id: 237561:CAALFM_C109170WA
uniprot id: Q5AQ33
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation of at least Ser-570, Thr-574, Ser-576 and Thr-577 in response to heat shock. Additional unidentified residues are also phosphorylated in response to heat shock.
messages: Belongs to the HSF family.
messages: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated during infection and contributes to full virulence.
messages: Homotrimer (By similarity). Homotrimerization increases the affinity of HSF1 to DNA (By similarity). Interacts with HSP90 (PubMed:23300438).
messages: Induced during exposure to the weak acid stress of acetic acid, through the regulation by the transcription factor MNL1.
messages: Leads to lethality.
messages: Nucleus

237561:CAALFM CR09290WA
gene id: 237561:CAALFM_CR09290WA
uniprot id: Q5A3Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

237561:CAALFM C401200CA
gene id: 237561:CAALFM_C401200CA
uniprot id: A0A1D8PL85
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

237561:CAALFM C204190CA
gene id: 237561:CAALFM_C204190CA
uniprot id: A0A1D8PH55
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C108230CA
gene id: 237561:CAALFM_C108230CA
uniprot id: A0A1D8PEB1
names: Similarity
messages: Belongs to the lysophospholipase family.

237561:CAALFM C304270CA
gene id: 237561:CAALFM_C304270CA
uniprot id: A0A1D8PJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C105420WA
gene id: 237561:CAALFM_C105420WA
uniprot id: Q5A2B8
names: Similarity
messages: Belongs to the DCP1 family.

237561:CAALFM C701350CA
gene id: 237561:CAALFM_C701350CA
uniprot id: A0A1D8PQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

237561:CAALFM C114030WA
gene id: 237561:CAALFM_C114030WA
uniprot id: A0A1D8PFU2
names: Similarity
messages: Belongs to the MEMO1 family.

237561:CAALFM C600980CA
gene id: 237561:CAALFM_C600980CA
uniprot id: A0A1D8PPI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

237561:CAALFM C305270CA
gene id: 237561:CAALFM_C305270CA
uniprot id: Q5AN98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C102460WA
gene id: 237561:CAALFM_C102460WA
uniprot id: Q5AIB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C403330WA
gene id: 237561:CAALFM_C403330WA
uniprot id: Q59KN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Nucleus
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

237561:CAALFM C305370CA
gene id: 237561:CAALFM_C305370CA
uniprot id: O42817
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. A 67 kDa form similar to the human laminin receptor (67LR) has been isolated from the cell walls of blastoconidia, but it does not bind laminin.

237561:CAALFM C201740CA
gene id: 237561:CAALFM_C201740CA
uniprot id: Q5ALU1
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial large ribosomal subunit.
messages: Mitochondrion

237561:CAALFM C203160CA
gene id: 237561:CAALFM_C203160CA
uniprot id: Q5A0N3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

237561:CAALFM C304060CA
gene id: 237561:CAALFM_C304060CA
uniprot id: Q59MR4
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

237561:CAALFM C101870CA
gene id: 237561:CAALFM_C101870CA
uniprot id: Q59T95
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

237561:CAALFM C400970CA
gene id: 237561:CAALFM_C400970CA
uniprot id: A0A1D8PL61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM CR06840WA
gene id: 237561:CAALFM_CR06840WA
uniprot id: Q59MU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

237561:CAALFM C404590WA
gene id: 237561:CAALFM_C404590WA
uniprot id: Q5A668
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C112970CA
gene id: 237561:CAALFM_C112970CA
uniprot id: Q5AL49
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC2 family.
messages: Bud neck
messages: Bud tip
messages: Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis (By similarity). Required for filamentous growth.
messages: Phosphorylated at Ser-584 and Ser-598. Phosphorylation at Ser-584 by the CDC28-CCN1 and CDC28-HGC1 complexes is required to support hyphal growth. In stationary phase and growing yeast cells, is constitutively phosphorylated, probably on more than one residue, but the pattern of phosphorylation rapidly changes upon hyphal induction and precedes the appearance of hyphal germ tubes.
messages: secretory vesicle

237561:CAALFM C206480WA
gene id: 237561:CAALFM_C206480WA
uniprot id: Q59Q39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.

237561:CAALFM C205610CA
gene id: 237561:CAALFM_C205610CA
uniprot id: Q59T44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C104700CA
gene id: 237561:CAALFM_C104700CA
uniprot id: A0A1D8PDD4
names: Similarity
messages: Belongs to the peptidase M28 family.

237561:CAALFM CR08510WA
gene id: 237561:CAALFM_CR08510WA
uniprot id: Q5A343
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Cell wall protein which contributes to cell wall synthesis and is important for acquiring normal surface properties. Required for virulence in a mouse infection model.
messages: Induced by caspofungin, tunicamycin, during chlamydospore formation and during cell wall regeneration following protoplasting. Repressed by NRG1 and TUP1. Also regulated by TSA1.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall
messages: leads to increased sensitivity to Congo red, Calcofluor white, and zymolyase, delayed filamentation, a higher surface hydrophobicity, increased adherence and flocculation; as well as to a diminished ability of protoplasts to recover their cell wall.

237561:CAALFM C704290WA
gene id: 237561:CAALFM_C704290WA
uniprot id: A0A1D8PRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

237561:CAALFM C204770WA
gene id: 237561:CAALFM_C204770WA
uniprot id: Q59LK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

237561:CAALFM C111040WA
gene id: 237561:CAALFM_C111040WA
uniprot id: A0A1D8PF57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL29 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM CR04810WA
gene id: 237561:CAALFM_CR04810WA
uniprot id: A0A1D8PSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C602880WA
gene id: 237561:CAALFM_C602880WA
uniprot id: A0A1D8PQ03
names: Similarity
messages: Belongs to the RNase H family.

237561:CAALFM C306200CA
gene id: 237561:CAALFM_C306200CA
uniprot id: A0A1D8PKF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

237561:CAALFM C200910WA
gene id: 237561:CAALFM_C200910WA
uniprot id: Q5AD34
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Predicted GPI-anchored protein which may have a role during host infection.
messages: Up-regulated upon interaction of cells with host macrophages and upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C403020WA
gene id: 237561:CAALFM_C403020WA
uniprot id: Q5AFB7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

237561:CAALFM C101280CA
gene id: 237561:CAALFM_C101280CA
uniprot id: Q5A917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C701600WA
gene id: 237561:CAALFM_C701600WA
uniprot id: Q5AGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

237561:CAALFM C206790WA
gene id: 237561:CAALFM_C206790WA
uniprot id: Q59Z68
names: Similarity
messages: Belongs to the PHF5 family.

237561:CAALFM C602500CA
gene id: 237561:CAALFM_C602500CA
uniprot id: A0A1D8PPW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

237561:CAALFM CR04840CA
gene id: 237561:CAALFM_CR04840CA
uniprot id: Q59N20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MSS11 family.
messages: Cytoplasm
messages: Interacts with FLO8.
messages: Nucleus
messages: Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.

237561:CAALFM C401820CA
gene id: 237561:CAALFM_C401820CA
uniprot id: Q5AMN5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

237561:CAALFM C404260CA
gene id: 237561:CAALFM_C404260CA
uniprot id: Q59P94
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

237561:CAALFM C109760CA
gene id: 237561:CAALFM_C109760CA
uniprot id: Q5APC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

237561:CAALFM C202620WA
gene id: 237561:CAALFM_C202620WA
uniprot id: A0A1D8PGP5
names: Similarity
messages: Belongs to the SDHAF4 family.

237561:CAALFM C201800WA
gene id: 237561:CAALFM_C201800WA
uniprot id: A0A1D8PGH8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

237561:CAALFM C203230CA
gene id: 237561:CAALFM_C203230CA
uniprot id: A0A1D8PGU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

237561:CAALFM C406760WA
gene id: 237561:CAALFM_C406760WA
uniprot id: A0A1D8PMP1
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

237561:CAALFM C406390WA
gene id: 237561:CAALFM_C406390WA
uniprot id: P87219
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol. Can also convert fructose to mannitol, but less efficiently.
messages: Homotetramer.

237561:CAALFM CR01310WA
gene id: 237561:CAALFM_CR01310WA
uniprot id: A0A1D8PRY3
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

237561:CAALFM C603690WA
gene id: 237561:CAALFM_C603690WA
uniprot id: Q5A8T7
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Forms amyloid structures, essential for cell-cell association and cell-substrate adhesion to polystyrene.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.
messages: Forms homodimers through the tandem repeats. Aggregates in amyloid-like structures, with self-propagating secondary-structure changes, amyloid-characteristic dye binding, and induced birefringence.
messages: Highly expressed in biofilms and during candidiasis infection dissemination.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C604110WA
gene id: 237561:CAALFM_C604110WA
uniprot id: A0A1D8PQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

237561:CAALFM C108330CA
gene id: 237561:CAALFM_C108330CA
uniprot id: O94038
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

237561:CAALFM C306470WA
gene id: 237561:CAALFM_C306470WA
uniprot id: P46589
names: Function
messages: Surface antigen mediating adhesion and aggregation in S.cerevisiae.

237561:CAALFM C404710WA
gene id: 237561:CAALFM_C404710WA
uniprot id: Q5A679
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM CR06700CA
gene id: 237561:CAALFM_CR06700CA
uniprot id: Q59PZ6
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

237561:CAALFM CR09420CA
gene id: 237561:CAALFM_CR09420CA
uniprot id: A0A1D8PTY8
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

237561:CAALFM C502490CA
gene id: 237561:CAALFM_C502490CA
uniprot id: A0A1D8PNF5
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

237561:CAALFM C603540WA
gene id: 237561:CAALFM_C603540WA
uniprot id: A0A1D8PQ72
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C104760CA
gene id: 237561:CAALFM_C104760CA
uniprot id: A0A1D8PDF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

237561:CAALFM C305530WA
gene id: 237561:CAALFM_C305530WA
uniprot id: A0A1D8PK87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

237561:CAALFM C603020WA
gene id: 237561:CAALFM_C603020WA
uniprot id: A0A1D8PQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

237561:CAALFM C600320CA
gene id: 237561:CAALFM_C600320CA
uniprot id: A0A1D8PPB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

237561:CAALFM CR00900WA
gene id: 237561:CAALFM_CR00900WA
uniprot id: Q5A863
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

237561:CAALFM C210240WA
gene id: 237561:CAALFM_C210240WA
uniprot id: Q59XU9
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

237561:CAALFM C100310WA
gene id: 237561:CAALFM_C100310WA
uniprot id: Q5AB93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Probably involved in transport through the plasma membrane.

237561:CAALFM C503430WA
gene id: 237561:CAALFM_C503430WA
uniprot id: Q59QT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C502810WA
gene id: 237561:CAALFM_C502810WA
uniprot id: A0A1D8PNJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

237561:CAALFM C112150CA
gene id: 237561:CAALFM_C112150CA
uniprot id: A0A1D8PFB7
names: Similarity
messages: Belongs to the ATG101 family.

237561:CAALFM C204180CA
gene id: 237561:CAALFM_C204180CA
uniprot id: A0A1D8PH37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C504400WA
gene id: 237561:CAALFM_C504400WA
uniprot id: Q5AK94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Cytoplasm
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
messages: Vacuole lumen

237561:CAALFM CR06070WA
gene id: 237561:CAALFM_CR06070WA
uniprot id: Q59V93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane

237561:CAALFM C600570CA
gene id: 237561:CAALFM_C600570CA
uniprot id: Q59NG8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

237561:CAALFM C206230WA
gene id: 237561:CAALFM_C206230WA
uniprot id: Q59P50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

237561:CAALFM CR07050CA
gene id: 237561:CAALFM_CR07050CA
uniprot id: A0A1D8PTD1
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

237561:CAALFM CR04470WA
gene id: 237561:CAALFM_CR04470WA
uniprot id: Q5A6L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

237561:CAALFM C701970CA
gene id: 237561:CAALFM_C701970CA
uniprot id: Q5AH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

237561:CAALFM C108870CA
gene id: 237561:CAALFM_C108870CA
uniprot id: Q5AQ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: nucleolus

237561:CAALFM C601910WA
gene id: 237561:CAALFM_C601910WA
uniprot id: Q5A4Q1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

237561:CAALFM C110210CA
gene id: 237561:CAALFM_C110210CA
uniprot id: Q5APR8
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Interacts (via the CRIB domain) with CDC42.
messages: Leads to defects in morphology and hyphal formation, impaired chlamydospore formation, reduced colonization of the kidneys in infected mice and suppressed virulence in the mouse model.
messages: Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection.
messages: The CRIB domain is involved in the interaction with CDC42.

237561:CAALFM C305030WA
gene id: 237561:CAALFM_C305030WA
uniprot id: Q5AND0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

237561:CAALFM C112930CA
gene id: 237561:CAALFM_C112930CA
uniprot id: Q5AL54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C104040CA
gene id: 237561:CAALFM_C104040CA
uniprot id: Q59QH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP9 family.
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
messages: nucleolus

237561:CAALFM CR08200CA
gene id: 237561:CAALFM_CR08200CA
uniprot id: A0A1D8PTN6
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C303340CA
gene id: 237561:CAALFM_C303340CA
uniprot id: A0A1D8PJR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C404660CA
gene id: 237561:CAALFM_C404660CA
uniprot id: Q5A675
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C306160CA
gene id: 237561:CAALFM_C306160CA
uniprot id: P0CU36
uniprot id: Q5A2Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
messages: nucleolus

237561:CAALFM C201670CA
gene id: 237561:CAALFM_C201670CA
uniprot id: Q5ALU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

237561:CAALFM C203360WA
gene id: 237561:CAALFM_C203360WA
uniprot id: Q5AHA6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

237561:CAALFM C502340CA
gene id: 237561:CAALFM_C502340CA
uniprot id: P0CY24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence.
messages: Nucleus

237561:CAALFM C204800CA
gene id: 237561:CAALFM_C204800CA
uniprot id: Q59LL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

237561:CAALFM C201520WA
gene id: 237561:CAALFM_C201520WA
uniprot id: Q5ALW7
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). Involved in the regulation of filamentous growth.

237561:CAALFM C204680WA
gene id: 237561:CAALFM_C204680WA
uniprot id: Q59LI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C303900CA
gene id: 237561:CAALFM_C303900CA
uniprot id: P48989
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-124.

237561:CAALFM C703530CA
gene id: 237561:CAALFM_C703530CA
uniprot id: Q59R35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the ISY1 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C303120CA
gene id: 237561:CAALFM_C303120CA
uniprot id: Q5AEF9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C504220WA
gene id: 237561:CAALFM_C504220WA
uniprot id: A0A1D8PNX0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C200540WA
gene id: 237561:CAALFM_C200540WA
uniprot id: Q5ACZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

237561:CAALFM C502980CA
gene id: 237561:CAALFM_C502980CA
uniprot id: Q5AG56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPT35 family.
messages: Endosome membrane
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.
messages: Vacuole membrane

237561:CAALFM CR04740CA
gene id: 237561:CAALFM_CR04740CA
uniprot id: Q59MZ5
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

237561:CAALFM C203670WA
gene id: 237561:CAALFM_C203670WA
uniprot id: A0A1D8PGZ9
names: Similarity
messages: Belongs to the peptidase A1 family.

237561:CAALFM C113330CA
gene id: 237561:CAALFM_C113330CA
uniprot id: Q5AL17
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

237561:CAALFM C105560WA
gene id: 237561:CAALFM_C105560WA
uniprot id: A0A1D8PDK6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

237561:CAALFM C206650CA
gene id: 237561:CAALFM_C206650CA
uniprot id: A0A1D8PHQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

237561:CAALFM C601010WA
gene id: 237561:CAALFM_C601010WA
uniprot id: Q59WU8
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

237561:CAALFM C302280CA
gene id: 237561:CAALFM_C302280CA
uniprot id: P53704
names: Function
names: Subunit
messages: Homotetramer.
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

237561:CAALFM C603790CA
gene id: 237561:CAALFM_C603790CA
uniprot id: Q5A8J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM CR10000CA
gene id: 237561:CAALFM_CR10000CA
uniprot id: A0A1D8PU47
names: Similarity
messages: Belongs to the MGMT family.

237561:CAALFM CR04660CA
gene id: 237561:CAALFM_CR04660CA
uniprot id: Q59KI0
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Expression is up-regulated during oropharyngeal candidiasis (OPC) infection and during stationary phase. Repressed by HOG1, BCR1 and hydrogen peroxide.
messages: Homooctamer.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.
messages: Present with 17200 molecules/cell in log phase SD medium.
messages: cell wall

237561:CAALFM C110630CA
gene id: 237561:CAALFM_C110630CA
uniprot id: A0A1D8PF12
names: Similarity
messages: Belongs to the SCC4/mau-2 family.

237561:CAALFM C104650WA
gene id: 237561:CAALFM_C104650WA
uniprot id: A0A1D8PDB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

237561:CAALFM CR07480WA
gene id: 237561:CAALFM_CR07480WA
uniprot id: A0A1D8PTH4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C303520CA
gene id: 237561:CAALFM_C303520CA
uniprot id: Q5AEB8
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

237561:CAALFM C104210CA
gene id: 237561:CAALFM_C104210CA
uniprot id: A0A1D8PD83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

237561:CAALFM C113540WA
gene id: 237561:CAALFM_C113540WA
uniprot id: Q5AKZ2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell membrane
messages: Changes ergosterol plasma membrane constitution and distribution and presents an increased resistance to azoles. Impairs the development of hyphae, adhesion, to invasion, and formation of biofilms, all of which are significant virulence factors.
messages: Endoplasmic reticulum membrane
messages: Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly. Involved in cell integrity and apoptosis (By similarity). Plays a role in virulence and antifungal resistance (PubMed:20843317).
messages: Mitochondrion membrane

237561:CAALFM C503360WA
gene id: 237561:CAALFM_C503360WA
uniprot id: Q59QT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

237561:CAALFM C209630CA
gene id: 237561:CAALFM_C209630CA
uniprot id: Q59YD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

237561:CAALFM C210530CA
gene id: 237561:CAALFM_C210530CA
uniprot id: Q5A5S5
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C500130CA
gene id: 237561:CAALFM_C500130CA
uniprot id: A0A1D8PMU5
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

237561:CAALFM C604490WA
gene id: 237561:CAALFM_C604490WA
uniprot id: Q9P8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

237561:CAALFM C600970CA
gene id: 237561:CAALFM_C600970CA
uniprot id: P0CY20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance (By similarity).

237561:CAALFM C400060WA
gene id: 237561:CAALFM_C400060WA
uniprot id: A0A1D8PL00
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

237561:CAALFM C503050CA
gene id: 237561:CAALFM_C503050CA
uniprot id: Q5AG46
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Up-regulated by TBF1 and upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM CR10850CA
gene id: 237561:CAALFM_CR10850CA
uniprot id: A0A1D8PUD2
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

237561:CAALFM C210270WA
gene id: 237561:CAALFM_C210270WA
uniprot id: A0A1D8PIN8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

237561:CAALFM CR08410WA
gene id: 237561:CAALFM_CR08410WA
uniprot id: Q5A356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

237561:CAALFM CR08560CA
gene id: 237561:CAALFM_CR08560CA
uniprot id: Q5A339
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

237561:CAALFM C406290WA
gene id: 237561:CAALFM_C406290WA
uniprot id: A0A1D8PMJ7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

237561:CAALFM C400770CA
gene id: 237561:CAALFM_C400770CA
uniprot id: Q59SK8
names: Similarity
names: Subunit
messages: Belongs to the DENR family.
messages: Interacts with the 40S ribosomal subunit.

237561:CAALFM C600590WA
gene id: 237561:CAALFM_C600590WA
uniprot id: A0A1D8PPF3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C200210WA
gene id: 237561:CAALFM_C200210WA
uniprot id: A0A1D8PG16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL38 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C210120WA
gene id: 237561:CAALFM_C210120WA
uniprot id: A0A1D8PIN9
names: Similarity
messages: Belongs to the phosducin family.

237561:CAALFM C704130CA
gene id: 237561:CAALFM_C704130CA
uniprot id: A0A1D8PRJ6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

237561:CAALFM C700760CA
gene id: 237561:CAALFM_C700760CA
uniprot id: A0A1D8PQN5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C207310WA
gene id: 237561:CAALFM_C207310WA
uniprot id: Q59Z12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

237561:CAALFM C406450WA
gene id: 237561:CAALFM_C406450WA
uniprot id: A0A1D8PML5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR02650CA
gene id: 237561:CAALFM_CR02650CA
uniprot id: Q5A218
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with TAH18. Interacts with MIA40.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

237561:CAALFM CR01770CA
gene id: 237561:CAALFM_CR01770CA
uniprot id: A0A1D8PS22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

237561:CAALFM C107830CA
gene id: 237561:CAALFM_C107830CA
uniprot id: A0A1D8PE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Nucleus

237561:CAALFM CR02430CA
gene id: 237561:CAALFM_CR02430CA
uniprot id: A0A1D8PS77
names: Similarity
messages: Belongs to the NFX1 family.

237561:CAALFM C400430WA
gene id: 237561:CAALFM_C400430WA
uniprot id: Q59UP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

237561:CAALFM C108400CA
gene id: 237561:CAALFM_C108400CA
uniprot id: A0A1D8PE97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

237561:CAALFM C602370CA
gene id: 237561:CAALFM_C602370CA
uniprot id: A0A1D8PPW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

237561:CAALFM C203390CA
gene id: 237561:CAALFM_C203390CA
uniprot id: Q96UX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. NBD1 is primarily responsible for ATP hydrolysis. NBD2 is crucial for oligomerization (By similarity).
messages: Homohexamer, forming a ring with a central pore.
messages: Mitochondrion matrix
messages: Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity).

237561:CAALFM C306030WA
gene id: 237561:CAALFM_C306030WA
uniprot id: A0A1D8PKD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM CR04090CA
gene id: 237561:CAALFM_CR04090CA
uniprot id: Q5A6R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

237561:CAALFM C103140WA
gene id: 237561:CAALFM_C103140WA
uniprot id: Q5AI45
names: Function
names: Similarity
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.

237561:CAALFM C700700WA
gene id: 237561:CAALFM_C700700WA
uniprot id: A0A1D8PQP7
names: Similarity
messages: Belongs to the cytochrome b5 family.

237561:CAALFM C103180WA
gene id: 237561:CAALFM_C103180WA
uniprot id: Q5AI42
names: Function
names: Similarity
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

237561:CAALFM CR02030CA
gene id: 237561:CAALFM_CR02030CA
uniprot id: Q5A962
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

237561:CAALFM C100410CA
gene id: 237561:CAALFM_C100410CA
uniprot id: A0A1D8PC76
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

237561:CAALFM C504280CA
gene id: 237561:CAALFM_C504280CA
uniprot id: A0A1D8PNX9
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM CR00670CA
gene id: 237561:CAALFM_CR00670CA
uniprot id: A0A1D8PRS2
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

237561:CAALFM C108460CA
gene id: 237561:CAALFM_C108460CA
uniprot id: Q59QC7
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Expression is up-regulated by ergosterol depletion, by azoles, and in anaerobic conditions. Transcript is repressed during co-incubated with macrophages, a condition that induces filamentous growth. Promotes positive auto-regulation through binding to its own promoter.
messages: Gain-of-function mutations in UPC2 are more prevalent among clinical isolates than previously thought and make a significant contribution to azole antifungal resistance.
messages: Nucleus
messages: Shows increased susceptibility to the azole drugs ketoconazole, itraconazole, and fluconazole; drugs that act on ergosterol biosynthesis such as terbinafine, fenpropimorph, and lovastatin; as well as malachite green. Leads to lower ergosterol levels. Decreases pyroptosis but has little effect on filamentation in the macrophage.
messages: Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.

237561:CAALFM C210220CA
gene id: 237561:CAALFM_C210220CA
uniprot id: A0A1D8PIP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

237561:CAALFM C600640CA
gene id: 237561:CAALFM_C600640CA
uniprot id: A0A1D8PPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

237561:CAALFM C110950CA
gene id: 237561:CAALFM_C110950CA
uniprot id: Q59WI0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

237561:CAALFM C106270WA
gene id: 237561:CAALFM_C106270WA
uniprot id: A0A1D8PDS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

237561:CAALFM C204580WA
gene id: 237561:CAALFM_C204580WA
uniprot id: A0A1D8PH78
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Expression is increased in the presence of fluconazole and decreased in the presence of lovastatin.
messages: Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:14653518). ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:14653518). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

237561:CAALFM C210720CA
gene id: 237561:CAALFM_C210720CA
uniprot id: Q5A5P7
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C111810WA
gene id: 237561:CAALFM_C111810WA
uniprot id: A0A1D8PF81
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

237561:CAALFM C203640WA
gene id: 237561:CAALFM_C203640WA
uniprot id: Q5AHE2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM CR09570WA
gene id: 237561:CAALFM_CR09570WA
uniprot id: A0A1D8PU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

237561:CAALFM C109400CA
gene id: 237561:CAALFM_C109400CA
uniprot id: A0A1D8PEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

237561:CAALFM C603140CA
gene id: 237561:CAALFM_C603140CA
uniprot id: A0A1D8PQ34
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C406190CA
gene id: 237561:CAALFM_C406190CA
uniprot id: Q5A1A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
messages: Nucleus

237561:CAALFM CR01830CA
gene id: 237561:CAALFM_CR01830CA
uniprot id: A0A1D8PS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

237561:CAALFM C503070WA
gene id: 237561:CAALFM_C503070WA
uniprot id: Q5AG43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C504720CA
gene id: 237561:CAALFM_C504720CA
uniprot id: A0A1D8PP19
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

237561:CAALFM CR01320CA
gene id: 237561:CAALFM_CR01320CA
uniprot id: A0A1D8PRZ2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR08350WA
gene id: 237561:CAALFM_CR08350WA
uniprot id: Q5A360
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIL1 family.
messages: Endoplasmic reticulum lumen
messages: Interacts with KAR2.
messages: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).

237561:CAALFM C112560CA
gene id: 237561:CAALFM_C112560CA
uniprot id: A0A1D8PFE4
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

237561:CAALFM C702770WA
gene id: 237561:CAALFM_C702770WA
uniprot id: Q5A594
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C400800WA
gene id: 237561:CAALFM_C400800WA
uniprot id: A0A1D8PL51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

237561:CAALFM C402890CA
gene id: 237561:CAALFM_C402890CA
uniprot id: A0A1D8PLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM CR04510WA
gene id: 237561:CAALFM_CR04510WA
uniprot id: P83776
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Monomer.

237561:CAALFM CR04880WA
gene id: 237561:CAALFM_CR04880WA
uniprot id: A0A1D8PSW2
names: Similarity
messages: Belongs to the threonine aldolase family.

237561:CAALFM CR10680WA
gene id: 237561:CAALFM_CR10680WA
uniprot id: A0A1D8PUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

237561:CAALFM C209810CA
gene id: 237561:CAALFM_C209810CA
uniprot id: A0A1D8PIK3
names: Similarity
messages: Belongs to the peptidase M20A family.

237561:CAALFM C105070CA
gene id: 237561:CAALFM_C105070CA
uniprot id: Q8TGB2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Cell-wall protein anchorage defects.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).

237561:CAALFM C403900CA
gene id: 237561:CAALFM_C403900CA
uniprot id: A0A1D8PLY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

237561:CAALFM C600440CA
gene id: 237561:CAALFM_C600440CA
uniprot id: A0A1D8PPC9
names: Similarity
messages: Belongs to the multicopper oxidase family.

237561:CAALFM C306800CA
gene id: 237561:CAALFM_C306800CA
uniprot id: Q5ADL9
names: Function
messages: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).

237561:CAALFM C601020WA
gene id: 237561:CAALFM_C601020WA
uniprot id: Q59WU8
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

237561:CAALFM CR05660WA
gene id: 237561:CAALFM_CR05660WA
uniprot id: Q59PR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

237561:CAALFM C100810WA
gene id: 237561:CAALFM_C100810WA
uniprot id: Q5ABE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).

237561:CAALFM C504620CA
gene id: 237561:CAALFM_C504620CA
uniprot id: A0A1D8PP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

237561:CAALFM C110460WA
gene id: 237561:CAALFM_C110460WA
uniprot id: A0A1D8PEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

237561:CAALFM CR05450CA
gene id: 237561:CAALFM_CR05450CA
uniprot id: A0A1D8PT01
names: Similarity
messages: Belongs to the MTFP1 family.

237561:CAALFM C113350WA
gene id: 237561:CAALFM_C113350WA
uniprot id: Q5AL16
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Exhibits reduced capacity to take up amino acids and to switch to the hyphal form, and impairs response to farnesol.
messages: Nucleus
messages: Proteolytically cleaved: activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain.
messages: Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyphal form.

237561:CAALFM C205950CA
gene id: 237561:CAALFM_C205950CA
uniprot id: Q59MF3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

237561:CAALFM C401440WA
gene id: 237561:CAALFM_C401440WA
uniprot id: P30418
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.
messages: Belongs to the NMT family.
messages: Competitively inhibited by SC-58272, a peptidomimetic derived from the N-terminal sequence of a natural substrate.
messages: Cytoplasm
messages: Has an ordered Bi-Bi kinetic mechanism, with myristoyl-CoA binding taking place prior to peptide binding and CoA release occurring before acylated peptide release. Cooperative interactions between the acyl-CoA and peptide binding sites of NMT contribute to its extraordinary chain-length specificity.
messages: Monomer.

237561:CAALFM C104800CA
gene id: 237561:CAALFM_C104800CA
uniprot id: A0A1D8PDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Secreted

237561:CAALFM C502740WA
gene id: 237561:CAALFM_C502740WA
uniprot id: Q5AG85
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

237561:CAALFM CR04040CA
gene id: 237561:CAALFM_CR04040CA
uniprot id: Q5A6R7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family.
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

237561:CAALFM C703490WA
gene id: 237561:CAALFM_C703490WA
uniprot id: A0A1D8PRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C204600CA
gene id: 237561:CAALFM_C204600CA
uniprot id: Q59TE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C306320WA
gene id: 237561:CAALFM_C306320WA
uniprot id: Q5A312
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: ALS7 gene corresponds to a hypermutable contingency locus meaning that the diversity of ALS7 proteins provide C.albicans with a large and flexible repertoire of similar but non-identical surface proteins which may be important not only for adhesion but also for evasion of host defenses.
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.
messages: Highly expressed in biofilms and during candidiasis infection dissemination.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR01480WA
gene id: 237561:CAALFM_CR01480WA
uniprot id: A0A1D8PRZ3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

237561:CAALFM C107840WA
gene id: 237561:CAALFM_C107840WA
uniprot id: A0A1D8PE45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

237561:CAALFM C703400CA
gene id: 237561:CAALFM_C703400CA
uniprot id: A0A1D8PRD5
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

237561:CAALFM C502260CA
gene id: 237561:CAALFM_C502260CA
uniprot id: A0A1D8PND1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

237561:CAALFM C604570WA
gene id: 237561:CAALFM_C604570WA
uniprot id: Q9C0L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization (By similarity). Required for virulence and resistance to cycloheximide.
messages: Endoplasmic reticulum membrane

237561:CAALFM C402720CA
gene id: 237561:CAALFM_C402720CA
uniprot id: A0A1D8PLM4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C401140CA
gene id: 237561:CAALFM_C401140CA
uniprot id: Q5AMH0
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

237561:CAALFM C109720WA
gene id: 237561:CAALFM_C109720WA
uniprot id: Q874I4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: In the de novo pyrimidine biosynthesis pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate with reduction of flavin and the transfer of electrons to ubiquinone, which is part of the respiratory chain. Does not use fumarate and NAD as electron acceptors.
messages: Inhibited by the dianisidine derivative redoxal and by brequinar.
messages: Mitochondrion inner membrane

237561:CAALFM C111300CA
gene id: 237561:CAALFM_C111300CA
uniprot id: Q59W52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
messages: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
messages: Component of the U5 snRNP complex.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

237561:CAALFM C303440CA
gene id: 237561:CAALFM_C303440CA
uniprot id: A0A1D8PJQ4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C404820CA
gene id: 237561:CAALFM_C404820CA
uniprot id: Q5A693
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

237561:CAALFM C304000CA
gene id: 237561:CAALFM_C304000CA
uniprot id: Q59MQ8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

237561:CAALFM C203320WA
gene id: 237561:CAALFM_C203320WA
uniprot id: Q5AHA0
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
messages: Expression is detected as early as 1 hour after infection of reconstituted human esophageal tissue and increases thereafter up to 48 hours postinfection. Expression is also increased when cells are exposed to several types of stress. Expression is decreased by Pseudomonas aeruginosa secretions. Moreover, expression is regulated by NGR1 and BCR1.
messages: Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent pro-inflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes.
messages: Impairs the hyphal formation and attenuates the virulence in a mouse systemic candidiasis model and towards reconstituted human esophageal tissue. Leads to extensive flocculation under conditions that stimulate germ-tube formation. Leads also to increased growth-inhibitory and killing effect by human neutrophils (polymorphonuclear leukocytes) and to hypersensitivity to fluconazole and voriconazole.
messages: The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-2007 (H1) in the histidine kinase domain (transmitter domain) to Asp-2394 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two CHK1 molecules, rather than intramolecularly (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

237561:CAALFM C113280CA
gene id: 237561:CAALFM_C113280CA
uniprot id: A0A1D8PFL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

237561:CAALFM C405270CA
gene id: 237561:CAALFM_C405270CA
uniprot id: A0A1D8PM97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Interacts with RAD51 and RAD52.
messages: Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.
messages: Nucleus

237561:CAALFM C400810CA
gene id: 237561:CAALFM_C400810CA
uniprot id: A0A1D8PL67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

237561:CAALFM C104970WA
gene id: 237561:CAALFM_C104970WA
uniprot id: Q59MA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

237561:CAALFM C103330CA
gene id: 237561:CAALFM_C103330CA
uniprot id: Q5AI22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Cytoplasm
messages: Membrane
messages: Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
messages: Vacuole membrane

237561:CAALFM C204010CA
gene id: 237561:CAALFM_C204010CA
uniprot id: Q5AHH4
names: Function
names: Induction
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol-induced stress. Required for invasive growth and filament formation under various filament inducing conditions. Plays a role in the capacity of damaging human-derived endothelial and oral epithelial cells during infection. Potentiates resistance to antifungal drugs, as well as resistance to killing by human neutrophils. Plays a major role in trehalose homeostasis in response to elevated temperatures. Regulates CEK1 activation by phosphorylation in response to elevated temperatures.
messages: Only expressed in stationary phase. Expression is increased in the absence of adenylyl cyclase and in biofilms.

237561:CAALFM C300090WA
gene id: 237561:CAALFM_C300090WA
uniprot id: Q5A7K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C205790CA
gene id: 237561:CAALFM_C205790CA
uniprot id: A0A1D8PHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

237561:CAALFM CR05050WA
gene id: 237561:CAALFM_CR05050WA
uniprot id: A0A1D8PSY1
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.

237561:CAALFM C102200CA
gene id: 237561:CAALFM_C102200CA
uniprot id: Q59VY1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to ATG12; which is essential for autophagy.
messages: Conjugated with ATG12.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
messages: Preautophagosomal structure membrane

237561:CAALFM C112730WA
gene id: 237561:CAALFM_C112730WA
uniprot id: Q59PE4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Component of a cytoskeletal structure that is required for membrane curvature.
messages: Does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by disruption in related RVS161 or RVS167.
messages: cytoskeleton

237561:CAALFM C404290WA
gene id: 237561:CAALFM_C404290WA
uniprot id: A0A1D8PM29
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

237561:CAALFM CR09210WA
gene id: 237561:CAALFM_CR09210WA
uniprot id: P33181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Affects sucrose utilization and alpha-glucosidase activity. Probable transcriptional activator.
messages: Belongs to the MAL13 family.
messages: Nucleus

237561:CAALFM C111380WA
gene id: 237561:CAALFM_C111380WA
uniprot id: A0A1D8PF50
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

237561:CAALFM C204570WA
gene id: 237561:CAALFM_C204570WA
uniprot id: A0A1D8PH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

237561:CAALFM C602070CA
gene id: 237561:CAALFM_C602070CA
uniprot id: A0A1D8PPT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C209380WA
gene id: 237561:CAALFM_C209380WA
uniprot id: A0A1D8PIJ2
names: Similarity
messages: Belongs to the RRP15 family.

237561:CAALFM C303870CA
gene id: 237561:CAALFM_C303870CA
uniprot id: Q59SU1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Cell membrane
messages: Induced by fluconazole. Expression is regulated by growth phase, temperature, and white-opaque switch.
messages: O-glycosylated.
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Involved in triggering host polymorphonuclear neutrophils chemotaxis toward germ tubes. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein. Required for cell surface integrity and cell separation during budding.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C403560WA
gene id: 237561:CAALFM_C403560WA
uniprot id: A0A1D8PLU9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

237561:CAALFM C207260CA
gene id: 237561:CAALFM_C207260CA
uniprot id: Q59Z17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.
messages: Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.

237561:CAALFM C102980WA
gene id: 237561:CAALFM_C102980WA
uniprot id: A0A1D8PCW3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM C106960WA
gene id: 237561:CAALFM_C106960WA
uniprot id: Q5AAU7
names: Similarity
messages: Belongs to the eIF-2-alpha family.

237561:CAALFM C111090CA
gene id: 237561:CAALFM_C111090CA
uniprot id: Q59WJ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

237561:CAALFM C401390WA
gene id: 237561:CAALFM_C401390WA
uniprot id: A0A1D8PLA9
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

237561:CAALFM C110860CA
gene id: 237561:CAALFM_C110860CA
uniprot id: Q59WH0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of SAGA complex, SALSA complex, and ADA complex.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B. Required for expression of many CAS5-dependent genes. Plays a key role in cell wall integrity, cell adhesion, hyphal development and pathogenesis.
messages: Nucleus

237561:CAALFM C107270WA
gene id: 237561:CAALFM_C107270WA
uniprot id: Q59WC9
names: Similarity
messages: Belongs to the COG3 family.

237561:CAALFM CR10420WA
gene id: 237561:CAALFM_CR10420WA
uniprot id: A0A1D8PU79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Mitochondrion inner membrane

237561:CAALFM C103740WA
gene id: 237561:CAALFM_C103740WA
uniprot id: Q59VQ8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Expression is induced in biofilm.
messages: Homodimer.
messages: Leads to sensitivity to weak organic acids and decreases cell adherence to silicone substrate.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide-responsive element (NORE) but seems not to be involved in response to nitrosative stress.

237561:CAALFM C603270CA
gene id: 237561:CAALFM_C603270CA
uniprot id: A0A1D8PQ42
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

237561:CAALFM C400880WA
gene id: 237561:CAALFM_C400880WA
uniprot id: A0A1D8PL79
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

237561:CAALFM C400280WA
gene id: 237561:CAALFM_C400280WA
uniprot id: A0A1D8PL01
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

237561:CAALFM CR05700CA
gene id: 237561:CAALFM_CR05700CA
uniprot id: Q59PS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

237561:CAALFM C101700WA
gene id: 237561:CAALFM_C101700WA
uniprot id: A0A1D8PCJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

237561:CAALFM C504100WA
gene id: 237561:CAALFM_C504100WA
uniprot id: A0A1D8PNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

237561:CAALFM C503020WA
gene id: 237561:CAALFM_C503020WA
uniprot id: Q5AG51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

237561:CAALFM CR07250CA
gene id: 237561:CAALFM_CR07250CA
uniprot id: A0A1D8PTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GMC oxidoreductase family.
messages: Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.
messages: Peroxisome matrix

237561:CAALFM CR10410CA
gene id: 237561:CAALFM_CR10410CA
uniprot id: Q5ACM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).
messages: Cytoplasm
messages: Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
messages: nucleolus

237561:CAALFM C208430CA
gene id: 237561:CAALFM_C208430CA
uniprot id: Q59Y11
names: Induction
names: Subcellular Location Annotation
messages: Cell membrane
messages: Secreted
messages: Up-regulated upon milbemycins A3 oxim derivative (A3Ox) treatment.

237561:CAALFM C104710CA
gene id: 237561:CAALFM_C104710CA
uniprot id: Q59VF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with nucleolar pre-ribosomal particles.
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

237561:CAALFM C500590WA
gene id: 237561:CAALFM_C500590WA
uniprot id: Q5A516
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane
messages: Monomer.

237561:CAALFM CR01170WA
gene id: 237561:CAALFM_CR01170WA
uniprot id: Q5A892
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

237561:CAALFM C405600WA
gene id: 237561:CAALFM_C405600WA
uniprot id: A0A1D8PMC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C306760WA
gene id: 237561:CAALFM_C306760WA
uniprot id: A0A1D8PKJ8
names: Similarity
messages: Belongs to the RRP1 family.

237561:CAALFM C604270WA
gene id: 237561:CAALFM_C604270WA
uniprot id: A0A1D8PQD2
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C603120WA
gene id: 237561:CAALFM_C603120WA
uniprot id: A0A1D8PQ25
names: Similarity
messages: Belongs to the MYBBP1A family.

237561:CAALFM C111420WA
gene id: 237561:CAALFM_C111420WA
uniprot id: Q59W63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

237561:CAALFM C109350WA
gene id: 237561:CAALFM_C109350WA
uniprot id: Q5AQ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
messages: Belongs to the CAF20 family.
messages: Cytoplasm

237561:CAALFM C601930WA
gene id: 237561:CAALFM_C601930WA
uniprot id: A0A1D8PPR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C402960WA
gene id: 237561:CAALFM_C402960WA
uniprot id: Q5AFB1
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

237561:CAALFM C107210CA
gene id: 237561:CAALFM_C107210CA
uniprot id: Q59WC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

237561:CAALFM C210710WA
gene id: 237561:CAALFM_C210710WA
uniprot id: Q5A5P8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

237561:CAALFM CR05140WA
gene id: 237561:CAALFM_CR05140WA
uniprot id: Q59QN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C403730CA
gene id: 237561:CAALFM_C403730CA
uniprot id: Q59TN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

237561:CAALFM C202270CA
gene id: 237561:CAALFM_C202270CA
uniprot id: Q5ALN2
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

237561:CAALFM C303430CA
gene id: 237561:CAALFM_C303430CA
uniprot id: Q5AEC8
names: Similarity
messages: Belongs to the VPS37 family.

237561:CAALFM C403800CA
gene id: 237561:CAALFM_C403800CA
uniprot id: A0A1D8PLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

237561:CAALFM CR10480WA
gene id: 237561:CAALFM_CR10480WA
uniprot id: Q5ACL7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE1 family.
messages: Cell membrane
messages: Induced during cell wall regeneration following protoplasting.
messages: Plays a role in cell wall stability and rigidity. Required for normal adhesion to host cells and for adherence during biofilm formation. Necessary for proper oxidative stress response.

237561:CAALFM CR05490WA
gene id: 237561:CAALFM_CR05490WA
uniprot id: A0A1D8PT00
names: Similarity
messages: Belongs to the TFIIB family.

237561:CAALFM C701220WA
gene id: 237561:CAALFM_C701220WA
uniprot id: A0A1D8PQT4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

237561:CAALFM C701900WA
gene id: 237561:CAALFM_C701900WA
uniprot id: Q5AH07
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

237561:CAALFM C101380CA
gene id: 237561:CAALFM_C101380CA
uniprot id: A0A1D8PCG3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

237561:CAALFM CR01140CA
gene id: 237561:CAALFM_CR01140CA
uniprot id: Q5A888
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3-keto-steroid reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:15552648). ERG27 is a catalytic component of the C-4 demethylation complex that catalyzes the reduction of the keto group on the C-3 (PubMed:15552648). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction …
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
messages: Endoplasmic reticulum membrane
messages: Expression is increased by itraconazole (which targets the lanosterol demethylase CYP51/ERG11) and by zaragozic acid A (which targets the squalene synthase ERG9).
messages: Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25 and ERG28. Also interacts with ERG7, but only in lipid particles (By similarity).
messages: Leads to complete loss of both 3-keto reductase and oxidosqualene cyclase (performed by ERG7) activities, compromising all sterol synthesis.
messages: Lipid droplet

237561:CAALFM C306120CA
gene id: 237561:CAALFM_C306120CA
uniprot id: Q8TGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Golgi apparatus membrane
messages: Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism.

237561:CAALFM C405460CA
gene id: 237561:CAALFM_C405460CA
uniprot id: A0A1D8PMB7
names: Similarity
messages: Belongs to the TPA1 family.

237561:CAALFM C501410CA
gene id: 237561:CAALFM_C501410CA
uniprot id: A0A1D8PN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C114120CA
gene id: 237561:CAALFM_C114120CA
uniprot id: Q59ZX3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Cell wall protein involved in cell wall integrity and which plays a role in virulence.
messages: Induced by ketoconazoland fluconazole; and repressed by EFG1, RIM101, SSN6, and alkaline conditions. Enriched in the media of yeast form-containing cultures. Expression is also regulated by HAP43, SEF1, and SFU1.
messages: cell wall

237561:CAALFM C202930CA
gene id: 237561:CAALFM_C202930CA
uniprot id: Q5A0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETT1 family.
messages: Nucleus
messages: Required for correct translation termination and probably involved in regulation of hypoxic gene expression.

237561:CAALFM CR07800WA
gene id: 237561:CAALFM_CR07800WA
uniprot id: P0DJ06
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae and true hyphae. Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers. Induced by fluconazole.
messages: Inhibited by squash aspartic peptidase inhibitor (SQAPI).
messages: Monomer.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C406020CA
gene id: 237561:CAALFM_C406020CA
uniprot id: Q59Q77
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

237561:CAALFM C113170CA
gene id: 237561:CAALFM_C113170CA
uniprot id: A0A1D8PFM1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

237561:CAALFM C205980CA
gene id: 237561:CAALFM_C205980CA
uniprot id: A0A1D8PHJ4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

237561:CAALFM C306430WA
gene id: 237561:CAALFM_C306430WA
uniprot id: A0A1D8PKJ7
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

237561:CAALFM C702060WA
gene id: 237561:CAALFM_C702060WA
uniprot id: P43075
names: Domain
names: Function
names: Similarity
messages: Belongs to the TRL1 family.
messages: Has three domains each corresponding to an enzymatic activity, namely in N- to C-terminal order: ligase, kinase and cyclic phosphodiesterase (CPDase).
messages: One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.

237561:CAALFM C209310CA
gene id: 237561:CAALFM_C209310CA
uniprot id: Q59X39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
messages: Belongs to the GatF family.
messages: Mitochondrion inner membrane
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

237561:CAALFM C501880CA
gene id: 237561:CAALFM_C501880CA
uniprot id: A0A1D8PNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

237561:CAALFM C503380WA
gene id: 237561:CAALFM_C503380WA
uniprot id: Q59QT2
names: Similarity
messages: Belongs to the actin family.

237561:CAALFM C404450CA
gene id: 237561:CAALFM_C404450CA
uniprot id: Q5A649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a ternary complex with ATG13 and ATG17.
messages: Preautophagosomal structure membrane
messages: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.

237561:CAALFM C501670WA
gene id: 237561:CAALFM_C501670WA
uniprot id: A0A1D8PN89
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C602870WA
gene id: 237561:CAALFM_C602870WA
uniprot id: Q5ABY8
names: Similarity
messages: Belongs to the RNase H family.

237561:CAALFM C207950WA
gene id: 237561:CAALFM_C207950WA
uniprot id: Q5A2S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

237561:CAALFM C304970CA
gene id: 237561:CAALFM_C304970CA
uniprot id: Q5AND8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

237561:CAALFM C203720WA
gene id: 237561:CAALFM_C203720WA
uniprot id: Q5AHE8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell surface GPI-anchored protein required for virulence. Mediates hyphal ramification which is important for the interaction with host cells.
messages: Leads to strong defects in host cell damage in a model of human oral epithelial cells, increased survival of infected mice, and aberrant filamentous morphology.

237561:CAALFM C205080CA
gene id: 237561:CAALFM_C205080CA
uniprot id: Q59ZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
messages: nucleolus

237561:CAALFM C202100WA
gene id: 237561:CAALFM_C202100WA
uniprot id: A0A1D8PGK4
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C501540WA
gene id: 237561:CAALFM_C501540WA
uniprot id: A0A1D8PN83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C114340CA
gene id: 237561:CAALFM_C114340CA
uniprot id: Q9UW14
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by C-terminal proteolytic cleavage. At neutral to alkaline ambient pH, the signaling protease (probably RIM13) cleaves RIM101 to yield the 74 kDa functional form. Also exists as a 65 kDa form at acidic pH, which may govern pH-independent processes.
messages: Belongs to the pacC/RIM101 family.
messages: Binds to DNA. Interacts with RIM20, which binds to the YPX[LI] motifs and is required for proteolytic processing (By similarity).
messages: By alkaline conditions.
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-CCAAGAA-3'. Required for the control of alkaline pH-induced filamentation (dimorphic switch) and virulence.

237561:CAALFM C307320WA
gene id: 237561:CAALFM_C307320WA
uniprot id: Q5ADT1
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with SIT4.
messages: Negatively regulates early sporulation-specific genes (By similarity). TOR signaling pathway component that contributes to morphogenesis as a regulator of this key morphogenetic pathway. Required for growth and hyphal formation at pH 9, for full virulence in a mouse model of systemic infection and for biofilm formation. Involved in chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
messages: Results in attenuated keratomycosis.

237561:CAALFM C103550CA
gene id: 237561:CAALFM_C103550CA
uniprot id: Q5AHZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

237561:CAALFM C703700CA
gene id: 237561:CAALFM_C703700CA
uniprot id: A0A1D8PRE0
names: Similarity
messages: Belongs to the bystin family.

237561:CAALFM C303290CA
gene id: 237561:CAALFM_C303290CA
uniprot id: A0A1D8PJR5
names: Similarity
messages: Belongs to the NPR2 family.

237561:CAALFM C600720CA
gene id: 237561:CAALFM_C600720CA
uniprot id: A0A1D8PPE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

237561:CAALFM C101110CA
gene id: 237561:CAALFM_C101110CA
uniprot id: Q5A934
names: Similarity
messages: Belongs to the ZPR1 family.

237561:CAALFM C208700CA
gene id: 237561:CAALFM_C208700CA
uniprot id: A0A1D8PI74
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

237561:CAALFM CR06810WA
gene id: 237561:CAALFM_CR06810WA
uniprot id: Q59VN2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

237561:CAALFM C700160CA
gene id: 237561:CAALFM_C700160CA
uniprot id: Q5AFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALB1 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.
messages: Cytoplasm
messages: Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
messages: Nucleus

237561:CAALFM C100650CA
gene id: 237561:CAALFM_C100650CA
uniprot id: Q5ABD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

237561:CAALFM C113710CA
gene id: 237561:CAALFM_C113710CA
uniprot id: A0A1D8PFP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

237561:CAALFM C305850WA
gene id: 237561:CAALFM_C305850WA
uniprot id: Q5A4G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV10 family.
messages: Cytoplasm
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
messages: Nucleus

237561:CAALFM C304470WA
gene id: 237561:CAALFM_C304470WA
uniprot id: Q5ANK2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

237561:CAALFM CR08700CA
gene id: 237561:CAALFM_CR08700CA
uniprot id: P22274
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

237561:CAALFM C305790CA
gene id: 237561:CAALFM_C305790CA
uniprot id: Q5A4H4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

237561:CAALFM CR04110WA
gene id: 237561:CAALFM_CR04110WA
uniprot id: A0A1D8PSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

237561:CAALFM C209720WA
gene id: 237561:CAALFM_C209720WA
uniprot id: Q59YE8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

237561:CAALFM C300260CA
gene id: 237561:CAALFM_C300260CA
uniprot id: Q5A7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

237561:CAALFM CR05510WA
gene id: 237561:CAALFM_CR05510WA
uniprot id: Q59M48
names: Similarity
messages: Belongs to the peptidase S9B family.

237561:CAALFM C302580CA
gene id: 237561:CAALFM_C302580CA
uniprot id: A0A1D8PJG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome

237561:CAALFM C503120WA
gene id: 237561:CAALFM_C503120WA
uniprot id: A0A1D8PNM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C200630CA
gene id: 237561:CAALFM_C200630CA
uniprot id: Q5AD02
names: Similarity
messages: Belongs to the allantoicase family.

237561:CAALFM C111800CA
gene id: 237561:CAALFM_C111800CA
uniprot id: Q59TV8
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

237561:CAALFM C305510WA
gene id: 237561:CAALFM_C305510WA
uniprot id: A0A1D8PK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

237561:CAALFM C104180WA
gene id: 237561:CAALFM_C104180WA
uniprot id: Q59VP1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-124.

237561:CAALFM CR09770CA
gene id: 237561:CAALFM_CR09770CA
uniprot id: Q5ACU3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Expressed at very low levels.
messages: Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation.
messages: Shows altered cell wall composition with a significant decrease in wall mannoproteins, and reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE).

237561:CAALFM C100390WA
gene id: 237561:CAALFM_C100390WA
uniprot id: Q5ABA1
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

237561:CAALFM C113380WA
gene id: 237561:CAALFM_C113380WA
uniprot id: Q5AL13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC26 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

237561:CAALFM C601670WA
gene id: 237561:CAALFM_C601670WA
uniprot id: Q5A4M2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

237561:CAALFM C301250WA
gene id: 237561:CAALFM_C301250WA
uniprot id: Q5AJ65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM C602740WA
gene id: 237561:CAALFM_C602740WA
uniprot id: A0A1D8PPZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

237561:CAALFM C602750CA
gene id: 237561:CAALFM_C602750CA
uniprot id: Q5AC02
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C208980CA
gene id: 237561:CAALFM_C208980CA
uniprot id: Q59SG9
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Induced during chlamydospore formation and filamentous growth. Expression is regulated by the NRG1 and TUP1 transcription factors.
messages: Predicted GPI-ancored adhesin-like protein which may be involved in filamentous growth and chlamydospore formation.
messages: The PGA55 mRNA is transported by SHE3 to bud in yeast cells, as well as to the hyphal tips during filamentous growth.

237561:CAALFM C110100CA
gene id: 237561:CAALFM_C110100CA
uniprot id: A0A1D8PES3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

237561:CAALFM CR10400WA
gene id: 237561:CAALFM_CR10400WA
uniprot id: A0A1D8PU80
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

237561:CAALFM C205100CA
gene id: 237561:CAALFM_C205100CA
uniprot id: Q59ZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

237561:CAALFM CR10620CA
gene id: 237561:CAALFM_CR10620CA
uniprot id: A0A1D8PUA1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

237561:CAALFM C702340CA
gene id: 237561:CAALFM_C702340CA
uniprot id: Q5AH60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit TRM8.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

237561:CAALFM C203540WA
gene id: 237561:CAALFM_C203540WA
uniprot id: A0A1D8PGZ5
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C204050CA
gene id: 237561:CAALFM_C204050CA
uniprot id: A0A1D8PH11
names: Similarity
messages: Belongs to the DOCK family.

237561:CAALFM C307640CA
gene id: 237561:CAALFM_C307640CA
uniprot id: A0A1D8PKV4
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

237561:CAALFM C304960WA
gene id: 237561:CAALFM_C304960WA
uniprot id: A0A1D8PK30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C702690CA
gene id: 237561:CAALFM_C702690CA
uniprot id: Q59M00
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

237561:CAALFM C505330CA
gene id: 237561:CAALFM_C505330CA
uniprot id: Q5AJZ3
names: Similarity
messages: Belongs to the UPP synthase family.

237561:CAALFM CR05220CA
gene id: 237561:CAALFM_CR05220CA
uniprot id: Q59KQ1
names: Similarity
messages: Belongs to the FGGY kinase family.

237561:CAALFM C405020WA
gene id: 237561:CAALFM_C405020WA
uniprot id: A0A1D8PM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

237561:CAALFM C401190WA
gene id: 237561:CAALFM_C401190WA
uniprot id: Q5AMH6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Leads to sensitivity to caspofungin and affects expression of many genes including caspofungin-responsive genes. Results in hyphal defect during C.elegans infection and exhibits attenuated virulence in flies and mice models for candidiasis.
messages: Nucleus
messages: Transcription factor involved in the cell wall damage response. Acts with ADA2 to promote cell wall integrity. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin-responsive genes. Plays a key role in adherence, hyphal development, and virulence.

237561:CAALFM C703130CA
gene id: 237561:CAALFM_C703130CA
uniprot id: Q5A5E0
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

237561:CAALFM C505390CA
gene id: 237561:CAALFM_C505390CA
uniprot id: Q5AJY5
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Leads to decreased caspofungin sensitivity.
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis. Plays a key role in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: Transcript levels are elevated during host infection, and transiently increased after induction of hyphal formation with serum. Expression is controlled by CWT1 and induced by fluconazole.
messages: cell wall

237561:CAALFM C209030WA
gene id: 237561:CAALFM_C209030WA
uniprot id: A0A1D8PIF3
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

237561:CAALFM CR03850WA
gene id: 237561:CAALFM_CR03850WA
uniprot id: Q5A032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

237561:CAALFM C601290CA
gene id: 237561:CAALFM_C601290CA
uniprot id: Q59XM0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. CAR1 family.
messages: Cell membrane
messages: Expression is repressed by HAP43.
messages: Leads to defects in biofilm architecture and attenuated virulence.
messages: MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.

237561:CAALFM C501680CA
gene id: 237561:CAALFM_C501680CA
uniprot id: Q59YH3
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cyclin family.
messages: Expression peaks at G1/S. CCN1 is stabilized during germ tube formation.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth.
messages: Interacts with CDC28. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction.

237561:CAALFM C112240CA
gene id: 237561:CAALFM_C112240CA
uniprot id: A0A1D8PFC1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

237561:CAALFM C307900CA
gene id: 237561:CAALFM_C307900CA
uniprot id: A0A1D8PKW7
names: Similarity
messages: Belongs to the TTI2 family.

237561:CAALFM C207470WA
gene id: 237561:CAALFM_C207470WA
uniprot id: A0A1D8PI01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

237561:CAALFM C113780WA
gene id: 237561:CAALFM_C113780WA
uniprot id: Q5AKW2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

237561:CAALFM C114130WA
gene id: 237561:CAALFM_C114130WA
uniprot id: A0A1D8PFV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

237561:CAALFM C106540CA
gene id: 237561:CAALFM_C106540CA
uniprot id: A0A1D8PDW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

237561:CAALFM C103780CA
gene id: 237561:CAALFM_C103780CA
uniprot id: A0A1D8PD39
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Expression is not affected by lovastatin or fluconazole.
messages: HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase HMG1 finally reduces HMG-CoA to produce mevalonate (Probable).

237561:CAALFM C104870WA
gene id: 237561:CAALFM_C104870WA
uniprot id: Q59VH7
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Contrary to other SAPs, SAP7 is insensitive to pepstatin A inhibition, which is due restriction of the accessibility of pepstatin A to the active site by Met-242 and Thr-467.
messages: Expression is regulated by SSN6 and induced during host infection.
messages: N-glycosylated.
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense.

237561:CAALFM C400460CA
gene id: 237561:CAALFM_C400460CA
uniprot id: A0A1D8PL46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

237561:CAALFM C103010WA
gene id: 237561:CAALFM_C103010WA
uniprot id: Q9HFQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Component of the large ribosomal subunit (LSU) (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (Probable). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Phosphorylated.

237561:CAALFM CR10450CA
gene id: 237561:CAALFM_CR10450CA
uniprot id: A0A1D8PU74
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C401760WA
gene id: 237561:CAALFM_C401760WA
uniprot id: Q5AMM9
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

237561:CAALFM C502030WA
gene id: 237561:CAALFM_C502030WA
uniprot id: A0A1D8PNA8
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

237561:CAALFM CR02620CA
gene id: 237561:CAALFM_CR02620CA
uniprot id: Q5A222
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM CR06160CA
gene id: 237561:CAALFM_CR06160CA
uniprot id: Q59VC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD3 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

237561:CAALFM C404320WA
gene id: 237561:CAALFM_C404320WA
uniprot id: Q59PA1
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C207800WA
gene id: 237561:CAALFM_C207800WA
uniprot id: Q5A2K4
names: Subcellular Location Annotation
messages: Mitochondrion

237561:CAALFM C200230WA
gene id: 237561:CAALFM_C200230WA
uniprot id: A0A1D8PG12
names: Similarity
messages: Belongs to the R-transferase family.

237561:CAALFM C602480WA
gene id: 237561:CAALFM_C602480WA
uniprot id: Q5AC33
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

237561:CAALFM C504990WA
gene id: 237561:CAALFM_C504990WA
uniprot id: Q5AK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

237561:CAALFM C111550WA
gene id: 237561:CAALFM_C111550WA
uniprot id: A0A1D8PF56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

237561:CAALFM C407050WA
gene id: 237561:CAALFM_C407050WA
uniprot id: Q5A0Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

237561:CAALFM C210480WA
gene id: 237561:CAALFM_C210480WA
uniprot id: Q5A5S6
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

237561:CAALFM C105980WA
gene id: 237561:CAALFM_C105980WA
uniprot id: Q5AA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

237561:CAALFM C203920CA
gene id: 237561:CAALFM_C203920CA
uniprot id: A0A1D8PGZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C209780CA
gene id: 237561:CAALFM_C209780CA
uniprot id: Q59YF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRC22 family.
messages: Endoplasmic reticulum membrane
messages: Is probably involved in a pathway contributing to genomic integrity.

237561:CAALFM C105510CA
gene id: 237561:CAALFM_C105510CA
uniprot id: A0A1D8PDP4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

237561:CAALFM C501580CA
gene id: 237561:CAALFM_C501580CA
uniprot id: P25997
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm
messages: Has antigenic properties.
messages: Monomer.
messages: Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (By similarity). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).

237561:CAALFM C201630WA
gene id: 237561:CAALFM_C201630WA
uniprot id: Q5ALV4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM CR03730CA
gene id: 237561:CAALFM_CR03730CA
uniprot id: Q5A016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

237561:CAALFM C505250CA
gene id: 237561:CAALFM_C505250CA
uniprot id: Q5AK02
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

237561:CAALFM C500940CA
gene id: 237561:CAALFM_C500940CA
uniprot id: A0A1D8PN26
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C104340CA
gene id: 237561:CAALFM_C104340CA
uniprot id: A0A1D8PDB8
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C703650WA
gene id: 237561:CAALFM_C703650WA
uniprot id: Q59R21
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

237561:CAALFM C502070CA
gene id: 237561:CAALFM_C502070CA
uniprot id: Q59YL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
messages: nucleolus

237561:CAALFM C700380WA
gene id: 237561:CAALFM_C700380WA
uniprot id: A0A1D8PQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

237561:CAALFM C104630CA
gene id: 237561:CAALFM_C104630CA
uniprot id: A0A1D8PDD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

237561:CAALFM C401750CA
gene id: 237561:CAALFM_C401750CA
uniprot id: Q9URB4
names: Allergen
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: Causes an allergic reaction in human. Binds to IgE.
messages: Cytoplasm
messages: Homodimer.

237561:CAALFM C202990CA
gene id: 237561:CAALFM_C202990CA
uniprot id: A0A1D8PGR6
names: Similarity
messages: Belongs to the oxoprolinase family.

237561:CAALFM C103030WA
gene id: 237561:CAALFM_C103030WA
uniprot id: A0A1D8PCW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C208600WA
gene id: 237561:CAALFM_C208600WA
uniprot id: A0A1D8PI64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

237561:CAALFM C604210CA
gene id: 237561:CAALFM_C604210CA
uniprot id: Q59R09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).

237561:CAALFM C701150WA
gene id: 237561:CAALFM_C701150WA
uniprot id: A0A1D8PQS1
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

237561:CAALFM C603010WA
gene id: 237561:CAALFM_C603010WA
uniprot id: Q5ABX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
messages: telomere

237561:CAALFM C207570WA
gene id: 237561:CAALFM_C207570WA
uniprot id: A0A1D8PI17
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

237561:CAALFM C301470WA
gene id: 237561:CAALFM_C301470WA
uniprot id: A0A1D8PJ64
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

237561:CAALFM C208360CA
gene id: 237561:CAALFM_C208360CA
uniprot id: Q5A741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

237561:CAALFM C102700CA
gene id: 237561:CAALFM_C102700CA
uniprot id: A0A1D8PCT3
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

237561:CAALFM CR00350WA
gene id: 237561:CAALFM_CR00350WA
uniprot id: A0A1D8PRN2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

237561:CAALFM C109780CA
gene id: 237561:CAALFM_C109780CA
uniprot id: Q5APC2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C203010CA
gene id: 237561:CAALFM_C203010CA
uniprot id: Q5A0L0
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

237561:CAALFM C104770CA
gene id: 237561:CAALFM_C104770CA
uniprot id: Q59VG6
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathwa (PubMed:9000517, PubMed:10433965, PubMed:20733039). ERG3 catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (PubMed:10433965). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduct…
messages: Defects in C-5 sterol desaturation results in antibiotic and azole resistance of Candida albicans during infection, particularly in AIDS patients.
messages: Endoplasmic reticulum membrane
messages: Expression is repressed during spider biofilm formation (PubMed:22265407).
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

237561:CAALFM C112790CA
gene id: 237561:CAALFM_C112790CA
uniprot id: Q59PF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

237561:CAALFM C201550WA
gene id: 237561:CAALFM_C201550WA
uniprot id: Q5ALW4
names: Similarity
messages: Belongs to the lipin family.

237561:CAALFM C108600CA
gene id: 237561:CAALFM_C108600CA
uniprot id: P87163
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).
messages: Subunit of the guanine nucleotide exchange factor for eIF-2.

237561:CAALFM C600670WA
gene id: 237561:CAALFM_C600670WA
uniprot id: Q59NH8
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
messages: Both during budding and hyphal growth, no detectable levels are observed in G1 cells but, as cells passe through S-phase, begins to accumulate with a peak being reached during mitosis.
messages: Bud neck
messages: Cell septum
messages: Cytoplasm
messages: Leads to defective cell separation and impairs hyphal growth.
messages: Mainly phosphorylated as the cells are passing through mitosis in yeast form cells. Phosphorylation is delayed in hyphal-induced cells, indicating that the timing of cell-cycle progression occurs with different kinetics in hyphae and in yeast cells.
messages: Protein phosphatase which antagonizes mitotic cyclin-dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydrolase genes such as CHT3 and ENG1 involved in septum degradation after cytokinesis. Also required for ACE2 localization to the daughter nucleus. Required for invasive and hyphal growth.
messages: nucleolus
messages: spindle pole

237561:CAALFM C210350CA
gene id: 237561:CAALFM_C210350CA
uniprot id: Q59XW4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

237561:CAALFM C107550WA
gene id: 237561:CAALFM_C107550WA
uniprot id: Q59PV3
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C703570WA
gene id: 237561:CAALFM_C703570WA
uniprot id: Q59R31
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

237561:CAALFM C401270WA
gene id: 237561:CAALFM_C401270WA
uniprot id: A0A1D8PL99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS6A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM C302300WA
gene id: 237561:CAALFM_C302300WA
uniprot id: Q5AJV5
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Affects filamentous growth.
messages: Cell membrane
messages: Induced in biofilms and by alpha factor. Repressed by HAP43.
messages: Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth.

237561:CAALFM C113020CA
gene id: 237561:CAALFM_C113020CA
uniprot id: Q5AL47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C301550CA
gene id: 237561:CAALFM_C301550CA
uniprot id: A0A1D8PJA8
names: Similarity
messages: Belongs to the PGA52 family.

237561:CAALFM C300880WA
gene id: 237561:CAALFM_C300880WA
uniprot id: A0A1D8PJ26
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

237561:CAALFM C400360CA
gene id: 237561:CAALFM_C400360CA
uniprot id: Q59UQ7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Bud neck
messages: Cell membrane
messages: Leads to modest tolerance to azoles and terbinafine, but not to amphotericin B and nystatin (PubMed:22530691). Elevates the intracellular Ca(2+) and leads to the activation of the calcium/calcineurin signaling pathway (PubMed:22530691).
messages: Solute carrier protein that negatively regulates the cytosolic homeostasis in response to high levels of extracellular calcium.

237561:CAALFM C204750WA
gene id: 237561:CAALFM_C204750WA
uniprot id: A0A1D8PH90
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C402880CA
gene id: 237561:CAALFM_C402880CA
uniprot id: Q5AF99
names: Similarity
messages: Belongs to the SDO1/SBDS family.

237561:CAALFM C107880CA
gene id: 237561:CAALFM_C107880CA
uniprot id: A0A1D8PE63
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

237561:CAALFM C101010WA
gene id: 237561:CAALFM_C101010WA
uniprot id: A0A1D8PCD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

237561:CAALFM C111790WA
gene id: 237561:CAALFM_C111790WA
uniprot id: Q59TV7
names: Similarity
messages: Belongs to the thymidylate kinase family.

237561:CAALFM CR09270CA
gene id: 237561:CAALFM_CR09270CA
uniprot id: P31225
names: Function
names: Similarity
messages: May be a flavoprotein with enzymatic activity.
messages: To yeast FMS1.

237561:CAALFM C503680WA
gene id: 237561:CAALFM_C503680WA
uniprot id: Q59NX5
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Induced during biofilm formation.
messages: Nucleus
messages: Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation.

237561:CAALFM C303270WA
gene id: 237561:CAALFM_C303270WA
uniprot id: Q5AEE2
names: Similarity
messages: Belongs to the OPA3 family.

237561:CAALFM C303230CA
gene id: 237561:CAALFM_C303230CA
uniprot id: A0A1D8PJQ5
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C100060WA
gene id: 237561:CAALFM_C100060WA
uniprot id: P0CY34
names: Disruption Phenotype
names: Function
names: Induction
messages: Expression is more than fourfold higher in white-phase cells than in opaque-phase cells. Up-regulated by farnesol in biofilm.
messages: Leads to exclusive filamentous growth.
messages: Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching.

237561:CAALFM CR05020WA
gene id: 237561:CAALFM_CR05020WA
uniprot id: Q59QM3
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR04500CA
gene id: 237561:CAALFM_CR04500CA
uniprot id: A0A1D8PSR6
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

237561:CAALFM C505170WA
gene id: 237561:CAALFM_C505170WA
uniprot id: Q5AK10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

237561:CAALFM C300290WA
gene id: 237561:CAALFM_C300290WA
uniprot id: A0A1D8PIV7
names: Similarity
messages: Belongs to the AAA ATPase family.

237561:CAALFM C204240CA
gene id: 237561:CAALFM_C204240CA
uniprot id: Q5AHK0
names: Similarity
messages: Belongs to the Mo25 family.

237561:CAALFM C202470CA
gene id: 237561:CAALFM_C202470CA
uniprot id: A0A1D8PGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C301410CA
gene id: 237561:CAALFM_C301410CA
uniprot id: A0A1D8PJ73
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

237561:CAALFM C702040CA
gene id: 237561:CAALFM_C702040CA
uniprot id: Q5AH24
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C503500WA
gene id: 237561:CAALFM_C503500WA
uniprot id: A0A1D8PNP3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Amino-acid permease with rather broad substrate specificity (PubMed:21764911). Transports many amino acids including proline, methionine, leucine, valine, isoleucine, phenylalanine, tryptophan, threonine and tyrosine, but not basic ones (arginine) and citrulline (PubMed:21764911, PubMed:28028545). Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Cell membrane
messages: Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is also regulated by PLC1 and GCN4 (PubMed:16207920, PubMed:16215176). Expression is induced during development of rat catheter biofilm (PubMed:19527170).

237561:CAALFM CR04170WA
gene id: 237561:CAALFM_CR04170WA
uniprot id: A0A1D8PSN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

237561:CAALFM C504590CA
gene id: 237561:CAALFM_C504590CA
uniprot id: A0A1D8PP14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

237561:CAALFM C502040WA
gene id: 237561:CAALFM_C502040WA
uniprot id: A0A1D8PNE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

237561:CAALFM C202660WA
gene id: 237561:CAALFM_C202660WA
uniprot id: Q5A0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

237561:CAALFM C202410WA
gene id: 237561:CAALFM_C202410WA
uniprot id: A0A1D8PGL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

237561:CAALFM CR07620WA
gene id: 237561:CAALFM_CR07620WA
uniprot id: Q59N40
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

237561:CAALFM C205700WA
gene id: 237561:CAALFM_C205700WA
uniprot id: Q59T35
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

237561:CAALFM C208800CA
gene id: 237561:CAALFM_C208800CA
uniprot id: A0A1D8PI95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28A subfamily.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Vacuole membrane

237561:CAALFM C406610CA
gene id: 237561:CAALFM_C406610CA
uniprot id: Q5A1E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

237561:CAALFM C407010CA
gene id: 237561:CAALFM_C407010CA
uniprot id: Q5A0Y8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: Nucleus
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

237561:CAALFM C503940CA
gene id: 237561:CAALFM_C503940CA
uniprot id: A0A1D8PNU2
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109200WA
gene id: 237561:CAALFM_C109200WA
uniprot id: A0A1D8PEH6
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C208180CA
gene id: 237561:CAALFM_C208180CA
uniprot id: A0A1D8PI86
names: Similarity
messages: Belongs to the SURF6 family.

237561:CAALFM C700120WA
gene id: 237561:CAALFM_C700120WA
uniprot id: Q5AFF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

237561:CAALFM CR06490CA
gene id: 237561:CAALFM_CR06490CA
uniprot id: O74261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chaperonin (HSP60) family.
messages: May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).
messages: Mitochondrion

237561:CAALFM C109570WA
gene id: 237561:CAALFM_C109570WA
uniprot id: Q5APE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

237561:CAALFM C304450CA
gene id: 237561:CAALFM_C304450CA
uniprot id: Q5ANK5
names: Similarity
messages: Belongs to the SUN family.

237561:CAALFM C600090WA
gene id: 237561:CAALFM_C600090WA
uniprot id: Q59L89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

237561:CAALFM C203300WA
gene id: 237561:CAALFM_C203300WA
uniprot id: A0A1D8PGU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

237561:CAALFM C500430WA
gene id: 237561:CAALFM_C500430WA
uniprot id: Q5A500
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

237561:CAALFM C204830WA
gene id: 237561:CAALFM_C204830WA
uniprot id: A0A1D8PH95
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

237561:CAALFM C502280CA
gene id: 237561:CAALFM_C502280CA
uniprot id: Q5AGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTR86 family.
messages: Cytoplasm
messages: Essential protein which may be involved in threonine biosynthesis.

237561:CAALFM C207170CA
gene id: 237561:CAALFM_C207170CA
uniprot id: Q59Z29
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Leads to hypersensitivity to oxidative stress.
messages: Nucleus
messages: Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity.

237561:CAALFM C104130WA
gene id: 237561:CAALFM_C104130WA
uniprot id: Q59VP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

237561:CAALFM C110940CA
gene id: 237561:CAALFM_C110940CA
uniprot id: A0A1D8PF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

237561:CAALFM CR05830CA
gene id: 237561:CAALFM_CR05830CA
uniprot id: A0A1D8PT33
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

237561:CAALFM C107490CA
gene id: 237561:CAALFM_C107490CA
uniprot id: A0A1D8PE62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

237561:CAALFM C700270WA
gene id: 237561:CAALFM_C700270WA
uniprot id: Q5AFH3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
messages: Highly sensible to fluoride. Growth is inhibited at more than a 300-fold lower fluoride concentration than in the wild-type. Has increased intracellular fluoride concentrations.

237561:CAALFM C603260WA
gene id: 237561:CAALFM_C603260WA
uniprot id: A0A1D8PQ43
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

237561:CAALFM C206260WA
gene id: 237561:CAALFM_C206260WA
uniprot id: Q59P48
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

237561:CAALFM C503570WA
gene id: 237561:CAALFM_C503570WA
uniprot id: Q59NY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CUE1 family.
messages: Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a heterodimer with UBC7.

237561:CAALFM CR02970CA
gene id: 237561:CAALFM_CR02970CA
uniprot id: A0A1D8PSC6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

237561:CAALFM C403850WA
gene id: 237561:CAALFM_C403850WA
uniprot id: A0A1D8PLY0
names: Subcellular Location Annotation
messages: nuclear pore complex

237561:CAALFM C600780WA
gene id: 237561:CAALFM_C600780WA
uniprot id: A0A1D8PPF9
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

237561:CAALFM C305110WA
gene id: 237561:CAALFM_C305110WA
uniprot id: Q5ANB9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C305590CA
gene id: 237561:CAALFM_C305590CA
uniprot id: A0A1D8PKB9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM C307080WA
gene id: 237561:CAALFM_C307080WA
uniprot id: Q5ADP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

237561:CAALFM C102990CA
gene id: 237561:CAALFM_C102990CA
uniprot id: P29717
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Binding of human antimicrobial peptide LL-37 decreases the catalytic activity, which leads to the decrease of cell adhesion.
messages: Expression is maximal during the early rapid growth phase and increases during biofilm growth. Induced by caspofungin. Transcripts is also regulated by RCK2, SIT4, and HTG4.
messages: Leads to enhanced susceptibility to the commonly used antifungal, fluconazole, during biofilm growth only.
messages: Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal infection. XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion.
messages: Monomer. Interacts with the human antimicrobial peptide LL-37.
messages: cell wall

237561:CAALFM C208850CA
gene id: 237561:CAALFM_C208850CA
uniprot id: Q59SC0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

237561:CAALFM C111400CA
gene id: 237561:CAALFM_C111400CA
uniprot id: Q59W62
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the septin complex which consists of CDC3, CDC10, CDC11, CDC12, and SEP7.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Bud neck
messages: Cytoplasm
messages: Hyperphosphorylated during mitosis at dozens of sites. Among these, 7 have perfect or minimal CDK consensus sites and are CDC28 targets.
messages: Leads to hyperinvasive cells.
messages: Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death.

237561:CAALFM C102290CA
gene id: 237561:CAALFM_C102290CA
uniprot id: A0A1D8PCP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

237561:CAALFM C502440CA
gene id: 237561:CAALFM_C502440CA
uniprot id: Q5AGC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus
messages: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).
messages: telomere

237561:CAALFM C504270CA
gene id: 237561:CAALFM_C504270CA
uniprot id: P83783
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.

237561:CAALFM C207210CA
gene id: 237561:CAALFM_C207210CA
uniprot id: A0A1D8PHU1
names: Similarity
messages: Belongs to the protein kinase superfamily.

237561:CAALFM C105530CA
gene id: 237561:CAALFM_C105530CA
uniprot id: A0A1D8PDL0
names: Similarity
messages: Belongs to the SecY/SEC61-alpha family.

237561:CAALFM C503610WA
gene id: 237561:CAALFM_C503610WA
uniprot id: A0A1D8PNR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

237561:CAALFM C102130CA
gene id: 237561:CAALFM_C102130CA
uniprot id: Q59VY8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

237561:CAALFM CR06860CA
gene id: 237561:CAALFM_CR06860CA
uniprot id: Q59MU3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

237561:CAALFM C101640WA
gene id: 237561:CAALFM_C101640WA
uniprot id: A0A1D8PCI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm

237561:CAALFM CR08160WA
gene id: 237561:CAALFM_CR08160WA
uniprot id: Q5A388
names: Similarity
messages: Belongs to the PP2C family.

237561:CAALFM C600700CA
gene id: 237561:CAALFM_C600700CA
uniprot id: A0A1D8PPG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

237561:CAALFM C104730CA
gene id: 237561:CAALFM_C104730CA
uniprot id: Q59VG1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

237561:CAALFM C203870WA
gene id: 237561:CAALFM_C203870WA
uniprot id: Q5AHF9
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

237561:CAALFM C110000CA
gene id: 237561:CAALFM_C110000CA
uniprot id: Q5APU2
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Derepresses filamentous growth and decreases virulence and resistance to cell wall and osmotic stress.
messages: Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch. Plays an important role in virulence. Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway. Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism.

237561:CAALFM C109440WA
gene id: 237561:CAALFM_C109440WA
uniprot id: Q5APF8
names: Similarity
messages: Belongs to the PPase family.

237561:CAALFM C202380WA
gene id: 237561:CAALFM_C202380WA
uniprot id: Q5ALL8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
messages: Nucleus

237561:CAALFM C206530WA
gene id: 237561:CAALFM_C206530WA
uniprot id: Q59Q35
names: Similarity
messages: Belongs to the Cdt1 family.

237561:CAALFM C600540WA
gene id: 237561:CAALFM_C600540WA
uniprot id: Q59NG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
messages: Interacts with EME1.
messages: Nucleus

237561:CAALFM C405080CA
gene id: 237561:CAALFM_C405080CA
uniprot id: A0A1D8PM90
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C502000CA
gene id: 237561:CAALFM_C502000CA
uniprot id: P83773
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Cytoplasm
messages: Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
messages: Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.

237561:CAALFM C501430CA
gene id: 237561:CAALFM_C501430CA
uniprot id: A0A1D8PN59
names: Similarity
messages: Belongs to the RPAP1 family.

237561:CAALFM C209750WA
gene id: 237561:CAALFM_C209750WA
uniprot id: A0A1D8PIF8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

237561:CAALFM C401360WA
gene id: 237561:CAALFM_C401360WA
uniprot id: Q5AMJ5
names: Subcellular Location Annotation
messages: Cell membrane

237561:CAALFM C207280WA
gene id: 237561:CAALFM_C207280WA
uniprot id: A0A1D8PHV4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

237561:CAALFM CR06870CA
gene id: 237561:CAALFM_CR06870CA
uniprot id: A0A1D8PTC0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C109640WA
gene id: 237561:CAALFM_C109640WA
uniprot id: P0CH96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

237561:CAALFM CR06900CA
gene id: 237561:CAALFM_CR06900CA
uniprot id: A0A1D8PTC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C502570WA
gene id: 237561:CAALFM_C502570WA
uniprot id: Q5AGA9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNN1/MNT family.
messages: Expression is regulated by SEF1, SFU1, and HAP43.
messages: Golgi apparatus membrane
messages: Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity).

237561:CAALFM C700020CA
gene id: 237561:CAALFM_C700020CA
uniprot id: Q5AFE4
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.
messages: Expression is induced in absence of HOG1 under non-stressed conditions.
messages: Leads to defects in actin polarization, endocytosis, bud morphogenesis, as well as increased sensitivity to calcofluor white and Congo red. Shows also a strong defect of hyphal morphogenesis and attenuated virulence.
messages: cytoskeleton

237561:CAALFM C110070CA
gene id: 237561:CAALFM_C110070CA
uniprot id: Q5AP90
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
messages: Belongs to the MNN1/MNT family.
messages: Golgi apparatus membrane
messages: Leads to hypersensitivity to toxic ergosterol analog, amphotericin B, calcofluor white, and to thermosensitivity.

237561:CAALFM C503850WA
gene id: 237561:CAALFM_C503850WA
uniprot id: Q59N79
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

237561:CAALFM C702890CA
gene id: 237561:CAALFM_C702890CA
uniprot id: O74189
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: PMT1 and PMT2 form a functional heterodimer.
messages: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentation and early phases of biofilm formation.
messages: Shows altered cell wall composition with a significant decrease in wall mannoproteins. Impairs biofilm formation and shows reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE) or engineered human oral mucosa (EHOM).
messages: Transcript levels are increased at least twofold by tunicamycin and Congo red. Both MSB2 and CEK1 are required to down-regulate PMT1 transcript levels in cells with intact glycostructures.

237561:CAALFM C301600WA
gene id: 237561:CAALFM_C301600WA
uniprot id: A0A1D8PJ80
names: Similarity
messages: Belongs to the PPP phosphatase family.

237561:CAALFM C202580WA
gene id: 237561:CAALFM_C202580WA
uniprot id: Q5ALJ4
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C111170WA
gene id: 237561:CAALFM_C111170WA
uniprot id: A0A1D8PF22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

237561:CAALFM C201650WA
gene id: 237561:CAALFM_C201650WA
uniprot id: Q5ALV0
names: Similarity
messages: Belongs to the MT-A70-like family.

237561:CAALFM C206540CA
gene id: 237561:CAALFM_C206540CA
uniprot id: Q59Q34
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

237561:CAALFM C210310CA
gene id: 237561:CAALFM_C210310CA
uniprot id: A0A1D8PIP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

237561:CAALFM C503800WA
gene id: 237561:CAALFM_C503800WA
uniprot id: Q59N74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
messages: Mitochondrion membrane

237561:CAALFM C206190WA
gene id: 237561:CAALFM_C206190WA
uniprot id: Q59P56
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

237561:CAALFM CR07070CA
gene id: 237561:CAALFM_CR07070CA
uniprot id: Q59L12
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALS family.
messages: Cell membrane
messages: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
messages: Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.
messages: Expression is under the positive control of the biofilm regulator BCR1, RLM1, TOR1 and TPK2; and under the negative control of SFL1. Induced during germ tube formation. Highly expressed in oropharyngeal candidiasis (OPC), a biofilm-like infection of the oral mucosa. Induced in the initial stages of biofilm formation. Down-regulated by human serum, as well as by bacterial quorum sensing quencher thiazolidinedione-8, pterostilbene, lipopeptides biosurfactant produced by B.amyloliquefaciens, and Riccardin D, a macrocyclic bisbibenzyl isolated from Chinese liverwort D.hirsute, which has an inhibitory effect on biofilms and virulence.
messages: Reduces adhesion and damage to both human umbilical vein endothelial cells (HUVEC) and oral epithelial cells.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C113580WA
gene id: 237561:CAALFM_C113580WA
uniprot id: A0A1D8PFN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

237561:CAALFM CR09160CA
gene id: 237561:CAALFM_CR09160CA
uniprot id: A0A1D8PTW6
names: Function
names: Induction
names: PTM
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Expressed during exponential and stationary growth phase (PubMed:17588813). Expression is repressed by amphotericin B and caspofungin (PubMed:15917516). Expression is also repressed during biofilm formation (PubMed:22265407).
messages: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase HMG1 finally reduces HMG-CoA to produce mevalonate (Probable).
messages: Is a probable target for sumoylation.

237561:CAALFM C400650WA
gene id: 237561:CAALFM_C400650WA
uniprot id: A0A1D8PL37
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

237561:CAALFM CR05890CA
gene id: 237561:CAALFM_CR05890CA
uniprot id: A0A1D8PT39
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

237561:CAALFM C600990WA
gene id: 237561:CAALFM_C600990WA
uniprot id: Q59WV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palI/RIM9 family.
messages: Membrane
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

237561:CAALFM C300310CA
gene id: 237561:CAALFM_C300310CA
uniprot id: Q5A7M8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C700980WA
gene id: 237561:CAALFM_C700980WA
uniprot id: A0A1D8PQR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
messages: Membrane
messages: Vacuole membrane

237561:CAALFM C604170CA
gene id: 237561:CAALFM_C604170CA
uniprot id: A0A1D8PQC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

237561:CAALFM CR09620CA
gene id: 237561:CAALFM_CR09620CA
uniprot id: A0A1D8PU11
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

237561:CAALFM C111610CA
gene id: 237561:CAALFM_C111610CA
uniprot id: A0A1D8PFA3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

237561:CAALFM C108010WA
gene id: 237561:CAALFM_C108010WA
uniprot id: A0A1D8PEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

237561:CAALFM C504430CA
gene id: 237561:CAALFM_C504430CA
uniprot id: A0A1D8PNY8
names: Similarity
messages: Belongs to the peptidase C12 family.

237561:CAALFM C206970WA
gene id: 237561:CAALFM_C206970WA
uniprot id: Q59ZB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
messages: Cytoplasm
messages: Nucleus

237561:CAALFM C502290WA
gene id: 237561:CAALFM_C502290WA
uniprot id: Q5AGE4
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

237561:CAALFM C206300WA
gene id: 237561:CAALFM_C206300WA
uniprot id: Q59P44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

237561:CAALFM C404780WA
gene id: 237561:CAALFM_C404780WA
uniprot id: Q5A688
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Expression is repressed by HAP4 and BCR1.
messages: Leads to supersensitivity to hygromycin B. Impairs filamentation, significantly reduces adherence to endothelial cells, and shows reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE).
messages: Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation and virulence.

237561:CAALFM C501230CA
gene id: 237561:CAALFM_C501230CA
uniprot id: Q5A1Q0
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

237561:CAALFM C113410WA
gene id: 237561:CAALFM_C113410WA
uniprot id: Q5AL10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX19 family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Required for the assembly of mitochondrial cytochrome c oxidase.

237561:CAALFM C703290CA
gene id: 237561:CAALFM_C703290CA
uniprot id: Q5A5M7
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: Expression is repressed by RIM101.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: cell wall

237561:CAALFM C703810WA
gene id: 237561:CAALFM_C703810WA
uniprot id: A0A1D8PRF5
names: Similarity
messages: Belongs to the SLA2 family.

237561:CAALFM C112590WA
gene id: 237561:CAALFM_C112590WA
uniprot id: Q59M30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

237561:CAALFM CR10540CA
gene id: 237561:CAALFM_CR10540CA
uniprot id: A0A1D8PU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

237561:CAALFM C700930WA
gene id: 237561:CAALFM_C700930WA
uniprot id: A0A1D8PQQ3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

237561:CAALFM C201730WA
gene id: 237561:CAALFM_C201730WA
uniprot id: Q5ALU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

237561:CAALFM CR05940WA
gene id: 237561:CAALFM_CR05940WA
uniprot id: A0A1D8PT38
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

237561:CAALFM C704270CA
gene id: 237561:CAALFM_C704270CA
uniprot id: A0A1D8PRK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

237561:CAALFM CR07370WA
gene id: 237561:CAALFM_CR07370WA
uniprot id: Q59RQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

237561:CAALFM CR04380CA
gene id: 237561:CAALFM_CR04380CA
uniprot id: Q5A6M6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

237561:CAALFM C203800CA
gene id: 237561:CAALFM_C203800CA
uniprot id: A0A1D8PGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C600950CA
gene id: 237561:CAALFM_C600950CA
uniprot id: A0A1D8PPI2
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

237561:CAALFM CR06180WA
gene id: 237561:CAALFM_CR06180WA
uniprot id: A0A1D8PT60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

237561:CAALFM C303690WA
gene id: 237561:CAALFM_C303690WA
uniprot id: A0A1D8PJT9
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C402570CA
gene id: 237561:CAALFM_C402570CA
uniprot id: A0A1D8PLL0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

237561:CAALFM C505080WA
gene id: 237561:CAALFM_C505080WA
uniprot id: A0A1D8PP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

237561:CAALFM CR05120WA
gene id: 237561:CAALFM_CR05120WA
uniprot id: Q59QN2
names: Similarity
messages: Belongs to the SAPS family.

237561:CAALFM C406100WA
gene id: 237561:CAALFM_C406100WA
uniprot id: A0A1D8PMH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

237561:CAALFM C202280WA
gene id: 237561:CAALFM_C202280WA
uniprot id: Q5ALN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM36 family.
messages: Mitochondrion membrane

237561:CAALFM C502930CA
gene id: 237561:CAALFM_C502930CA
uniprot id: A0A1D8PNK3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

237561:CAALFM CR02950CA
gene id: 237561:CAALFM_CR02950CA
uniprot id: Q5A1Z1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

237561:CAALFM C600280WA
gene id: 237561:CAALFM_C600280WA
uniprot id: Q59RL7
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Impairs expression of hypha-specific transcripts and leads to a medium-specific impairment in hyphal development.
messages: Nucleus
messages: Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1-like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion.
messages: Up-regulated during the yeast-to-hypha transition and in virulent strains during intestinal colonization. Also induced upon exposure to fluconazole. Expression is down-regulated by tetrandrine and by Escherichia coli biofilm secretory products.

237561:CAALFM CR00420WA
gene id: 237561:CAALFM_CR00420WA
uniprot id: A0A1D8PRS0
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM C105660CA
gene id: 237561:CAALFM_C105660CA
uniprot id: A0A1D8PDK7
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

237561:CAALFM C100800CA
gene id: 237561:CAALFM_C100800CA
uniprot id: A0A1D8PCB9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reductio…
messages: Endoplasmic reticulum membrane
messages: Expression is repressed during biofilm formation.
messages: Increases the susceptibility to 4-nitroquinoline oxide, terbinafine, o-phenanthroline, itraconazole, and ketoconazole (PubMed:15105135). Affects the proper surface localization of the drug transporter CDR1 (PubMed:15105135).

237561:CAALFM C704280CA
gene id: 237561:CAALFM_C704280CA
uniprot id: A0A1D8PRK7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

237561:CAALFM CR10110WA
gene id: 237561:CAALFM_CR10110WA
uniprot id: P40954
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
messages: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
messages: Expression is positively regulated by ACE2. Transcription is greater during growth of the yeast form as compared to the mycelial form, and down-regulated by micafungin treatment.
messages: Leads to strong decrease of secreted chitinase activity, as well as to the clumping or clusterings of cells from early exponential phase.
messages: Secreted

237561:CAALFM C600170CA
gene id: 237561:CAALFM_C600170CA
uniprot id: A0A1D8PP95
names: Similarity
messages: Belongs to the peptidase C19 family.

237561:CAALFM C703320CA
gene id: 237561:CAALFM_C703320CA
uniprot id: Q59PP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

237561:CAALFM C107820WA
gene id: 237561:CAALFM_C107820WA
uniprot id: Q5A7A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

237561:CAALFM C600560WA
gene id: 237561:CAALFM_C600560WA
uniprot id: A0A1D8PPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

237561:CAALFM C101040WA
gene id: 237561:CAALFM_C101040WA
uniprot id: Q5A942
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

237561:CAALFM C307660WA
gene id: 237561:CAALFM_C307660WA
uniprot id: Q5ADX0
names: Similarity
messages: Belongs to the XPC family.

237561:CAALFM C603490CA
gene id: 237561:CAALFM_C603490CA
uniprot id: P0CY27
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Expressed during development of germ tubes, pseudohyphae, true hyphae and opaque cells. Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers. Regulated by growth phase and alpha-pheromones.
messages: Inhibited by pepstatin A analogs and squash aspartic peptidase inhibitor (SQAPI).
messages: O-glycosylated.
messages: Secreted
messages: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.

237561:CAALFM C108260CA
gene id: 237561:CAALFM_C108260CA
uniprot id: A0A1D8PE91
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

237561:CAALFM C103190CA
gene id: 237561:CAALFM_C103190CA
uniprot id: A0A1D8PCY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

237561:CAALFM C602230WA
gene id: 237561:CAALFM_C602230WA
uniprot id: Q59S77
names: Function
names: Subcellular Location Annotation
messages: May be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion

237561:CAALFM C307000WA
gene id: 237561:CAALFM_C307000WA
uniprot id: Q5ADP0
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

237561:CAALFM C303500WA
gene id: 237561:CAALFM_C303500WA
uniprot id: Q5AEC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

237561:CAALFM C503530CA
gene id: 237561:CAALFM_C503530CA
uniprot id: A0A1D8PNQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

237561:CAALFM C110880WA
gene id: 237561:CAALFM_C110880WA
uniprot id: A0A1D8PF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

237561:CAALFM C406310CA
gene id: 237561:CAALFM_C406310CA
uniprot id: Q5A1B3
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: Membrane
messages: Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).
messages: Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment.
messages: cell wall

237561:CAALFM C700470CA
gene id: 237561:CAALFM_C700470CA
uniprot id: A0A1D8PQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

237561:CAALFM C104000CA
gene id: 237561:CAALFM_C104000CA
uniprot id: Q59QH4
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

237561:CAALFM C500900CA
gene id: 237561:CAALFM_C500900CA
uniprot id: Q5A1L8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

237561:CAALFM C603400CA
gene id: 237561:CAALFM_C603400CA
uniprot id: Q5ABS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

237561:CAALFM C303480CA
gene id: 237561:CAALFM_C303480CA
uniprot id: A0A1D8PJP4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

237561:CAALFM C306330WA
gene id: 237561:CAALFM_C306330WA
uniprot id: P0CU34
uniprot id: Q9Y7F0
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cell surface
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation.
messages: Induced by oxidative stress.
messages: Nucleus
messages: Results in delayed hyphal development and enhanced sensitivity to cell wall-perturbing agents, yet does not impair virulence in vivo.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.

237561:CAALFM CR07030CA
gene id: 237561:CAALFM_CR07030CA
uniprot id: Q59SN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
messages: nucleolus

237561:CAALFM C112840WA
gene id: 237561:CAALFM_C112840WA
uniprot id: Q5AL63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: The MHF histone-fold complex is a heterotetramer of 2 MHF1-MHF2 heterodimers. Together with MPH1/FANCM, forms the FANCM-MHF complex. Component of the inner kinetochore constitutive centromere-associated network (CCAN).
messages: dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).

237561:CAALFM C201410CA
gene id: 237561:CAALFM_C201410CA
uniprot id: Q5ALY0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Expressed from S phase through G2 and M phases and are degraded at the end of mitosis. Expression is down-regulated by the anti-fungal agent plagiochin E (PLE).
messages: Impairs macrophage killing during infection.

237561:CAALFM C503590WA
gene id: 237561:CAALFM_C503590WA
uniprot id: A0A1D8PNQ9
names: Similarity
messages: Belongs to the peptidase M18 family.

237561:CAALFM C403040WA
gene id: 237561:CAALFM_C403040WA
uniprot id: A0A1D8PLR5
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

237561:CAALFM C603850CA
gene id: 237561:CAALFM_C603850CA
uniprot id: Q5A8I8
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IHD1 family.
messages: GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.
messages: Induced during yeast to hyphae transition, during biofilm formation, during oralpharyngeal candidasis, and in response to serum. Regulated BY FLO8, NRG1, RFG1, RGT1, TUP1, TSA1, and UME6.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM C303710WA
gene id: 237561:CAALFM_C303710WA
uniprot id: Q59SS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

237561:CAALFM C406480CA
gene id: 237561:CAALFM_C406480CA
uniprot id: Q5A1D3
names: Activity Regulation
names: Domain
names: PTM
names: Similarity
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-230 and Tyr-232, which activates the enzyme.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

237561:CAALFM C504860CA
gene id: 237561:CAALFM_C504860CA
uniprot id: A0A1D8PP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

237561:CAALFM C602320CA
gene id: 237561:CAALFM_C602320CA
uniprot id: Q59S66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Nucleus
messages: Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity).
messages: kinetochore
messages: spindle

237561:CAALFM C700370WA
gene id: 237561:CAALFM_C700370WA
uniprot id: A0A1D8PQK7
names: Similarity
messages: Belongs to the DCC1 family.

237561:CAALFM C500180WA
gene id: 237561:CAALFM_C500180WA
uniprot id: A0A1D8PMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

237561:CAALFM C102240WA
gene id: 237561:CAALFM_C102240WA
uniprot id: Q59VX7
names: Subcellular Location Annotation
messages: Cytoplasm

237561:CAALFM C700670CA
gene id: 237561:CAALFM_C700670CA
uniprot id: A0A1D8PQN8
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

237561:CAALFM C406770WA
gene id: 237561:CAALFM_C406770WA
uniprot id: Q5A0W4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

237561:CAALFM CR01220WA
gene id: 237561:CAALFM_CR01220WA
uniprot id: Q5A896
names: Subcellular Location Annotation
messages: Membrane

237561:CAALFM CR01300WA
gene id: 237561:CAALFM_CR01300WA
uniprot id: A0A1D8PRX9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

237561:CAALFM CR03600CA
gene id: 237561:CAALFM_CR03600CA
uniprot id: Q5A006
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

237561:CAALFM C704310CA
gene id: 237561:CAALFM_C704310CA
uniprot id: A0A1D8PRK5
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

237561:CAALFM C106550WA
gene id: 237561:CAALFM_C106550WA
uniprot id: A0A1D8PDU9
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

237561:CAALFM C209860CA
gene id: 237561:CAALFM_C209860CA
uniprot id: A0A1D8PIJ1
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

237561:CAALFM C209470CA
gene id: 237561:CAALFM_C209470CA
uniprot id: A0A1D8PII6
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

237561:CAALFM C700420CA
gene id: 237561:CAALFM_C700420CA
uniprot id: A0A1D8PQL7
names: Similarity
messages: Belongs to the UPF0357 family.

237561:CAALFM C303530WA
gene id: 237561:CAALFM_C303530WA
uniprot id: Q5AEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

237561:CAALFM C500980WA
gene id: 237561:CAALFM_C500980WA
uniprot id: Q5A1M4
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Decreases cell adherence to silicone substrate.
messages: Expression is induced in biofilm.
messages: Nucleus
messages: Transcription factor required for yeast cell adherence to silicone substrate.

237561:CAALFM CR01060WA
gene id: 237561:CAALFM_CR01060WA
uniprot id: Q5A879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

237561:CAALFM CR00930WA
gene id: 237561:CAALFM_CR00930WA
uniprot id: Q5A865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

237561:CAALFM C300690CA
gene id: 237561:CAALFM_C300690CA
uniprot id: Q5A7S8
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C208580WA
gene id: 237561:CAALFM_C208580WA
uniprot id: A0A1D8PI63
names: Subcellular Location Annotation
messages: cell wall

237561:CAALFM C209270CA
gene id: 237561:CAALFM_C209270CA
uniprot id: A0A1D8PIG5
names: Similarity
messages: Belongs to the SGT1 family.

237561:CAALFM C307850WA
gene id: 237561:CAALFM_C307850WA
uniprot id: Q59MJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Probable transporter.
messages: Vacuole membrane

237561:CAALFM C209390WA
gene id: 237561:CAALFM_C209390WA
uniprot id: A0A1D8PIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

237561:CAALFM C110730WA
gene id: 237561:CAALFM_C110730WA
uniprot id: A0A1D8PF26
names: Similarity
messages: Belongs to the SELO family.

237561:CAALFM CR03630WA
gene id: 237561:CAALFM_CR03630WA
uniprot id: Q5A029
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYR1/IFF family.
messages: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
messages: Membrane
messages: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
messages: cell wall

237561:CAALFM CR09960CA
gene id: 237561:CAALFM_CR09960CA
uniprot id: A0A1D8PU36
names: Subcellular Location Annotation
messages: Nucleus

237561:CAALFM C404770CA
gene id: 237561:CAALFM_C404770CA
uniprot id: Q5A687
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.
messages: Belongs to the MNN1/MNT family.
messages: Expression is induced by nitric oxide (NO) and HOG1; and repressed by osmotic stress, oxidative stress, and heavy metal stress. Expression is also regulated by TSA1.
messages: Golgi apparatus membrane

237561:CAALFM C204590CA
gene id: 237561:CAALFM_C204590CA
uniprot id: A0A1D8PHA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

237561:CAALFM C701440WA
gene id: 237561:CAALFM_C701440WA
uniprot id: Q5AGV3
names: Similarity
messages: Belongs to the BolA/IbaG family.

237561:CAALFM C206640CA
gene id: 237561:CAALFM_C206640CA
uniprot id: A0A1D8PHR0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

237561:CAALFM C602130CA
gene id: 237561:CAALFM_C602130CA
uniprot id: A0A1D8PPT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

237561:CAALFM C406530CA
gene id: 237561:CAALFM_C406530CA
uniprot id: Q5A1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

237561:CAALFM CR10120CA
gene id: 237561:CAALFM_CR10120CA
uniprot id: A0A1D8PU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG7 family.
messages: Mitochondrion

237561:CAALFM C203820CA
gene id: 237561:CAALFM_C203820CA
uniprot id: A0A1D8PGY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS9B is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
messages: Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).
messages: Cytoplasm