229533:FGSG 05200
gene id: 229533:FGSG_05200
uniprot id: I1RMK9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy (By similarity). Required for both micropexophagy and macropexophagy, but not for the cytoplasm to vacuole transport (Cvt) or autophagy pathways (By similarity). Required for functional micropexophagic apparatus (MIPA) and relocation of ATG11 to the peroxisome-sequestering arms of the vacuole (By similarity). Binds palmytoyl-CoA but not oleyl-CoA (By similarity).
messages: Belongs to the ATG37 family.
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).
messages: Peroxisome membrane

229533:FGSG 11094
gene id: 229533:FGSG_11094
uniprot id: I1S2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

229533:FGSG 03711
gene id: 229533:FGSG_03711
uniprot id: I1RIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02054
gene id: 229533:FGSG_02054
uniprot id: I1REG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

229533:FGSG 00091
gene id: 229533:FGSG_00091
uniprot id: I1R9F3
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 07038
gene id: 229533:FGSG_07038
uniprot id: V6RGY3
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

229533:FGSG 03844
gene id: 229533:FGSG_03844
uniprot id: I1RJ43
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09801
gene id: 229533:FGSG_09801
uniprot id: I1RZG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

229533:FGSG 02662
gene id: 229533:FGSG_02662
uniprot id: I1RG13
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07007
gene id: 229533:FGSG_07007
uniprot id: I1RS93
names: Similarity
messages: Belongs to the syntaxin family.

229533:FGSG 06642
gene id: 229533:FGSG_06642
uniprot id: I1RRC4
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

229533:FGSG 05724
gene id: 229533:FGSG_05724
uniprot id: I1RNX9
names: Similarity
names: Subunit
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
messages: Homotetramer.

229533:FGSG 01959
gene id: 229533:FGSG_01959
uniprot id: I1RE80
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: C-22 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG5A and ERG5B convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role a…
messages: Endoplasmic reticulum membrane
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Leads to a severe decrease in conidiation and virulence when ERG5B is also deleted (PubMed:23442154). The absence of both ERG5A and ERG5B seems not to affect the ergosterol production (PubMed:24785759).

229533:FGSG 04143
gene id: 229533:FGSG_04143
uniprot id: I1RJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

229533:FGSG 04287
gene id: 229533:FGSG_04287
uniprot id: I1RK93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the dehydroquinate synthase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

229533:FGSG 08658
gene id: 229533:FGSG_08658
uniprot id: I1RWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

229533:FGSG 11622
gene id: 229533:FGSG_11622
uniprot id: I1S461
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

229533:FGSG 11677
gene id: 229533:FGSG_11677
uniprot id: I1S4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

229533:FGSG 08221
gene id: 229533:FGSG_08221
uniprot id: I1RVE8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06752
gene id: 229533:FGSG_06752
uniprot id: V6RF62
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 07482
gene id: 229533:FGSG_07482
uniprot id: I1RTH7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10907
gene id: 229533:FGSG_10907
uniprot id: I1S2B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

229533:FGSG 05393
gene id: 229533:FGSG_05393
uniprot id: I1RN31
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 01245
gene id: 229533:FGSG_01245
uniprot id: A0A1I9EY47
uniprot id: Q4ING3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Forms a one-to-one complex with cytochrome c.
messages: Mitochondrion matrix

229533:FGSG 13310
gene id: 229533:FGSG_13310
uniprot id: I1S8Y1
names: Similarity
messages: Belongs to the PET191 family.

229533:FGSG 01000
gene id: 229533:FGSG_01000
uniprot id: I1RBR4
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases; and leads to the accumulation of eburicol and 2 additional 14-methylated sterols, 4,4,14-trimethylergosta-trienol and 4,4,14-trimethylergosta-dienol (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).
messages: Endoplasmic reticulum membrane
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Together with cyp51A and cyp51C, encodes the sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:20955812, PubMed:23442154). Essential for ascospore production (PubMed:23442154). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (Probable). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4'-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).

229533:FGSG 04131
gene id: 229533:FGSG_04131
uniprot id: I1RJU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 06724
gene id: 229533:FGSG_06724
uniprot id: I1RRJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

229533:FGSG 01963
gene id: 229533:FGSG_01963
uniprot id: I1RE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

229533:FGSG 06767
gene id: 229533:FGSG_06767
uniprot id: I1RRN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

229533:FGSG 12669
gene id: 229533:FGSG_12669
uniprot id: I1S746
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

229533:FGSG 10666
gene id: 229533:FGSG_10666
uniprot id: I1S1Q3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sterol desaturase family.
messages: C-4 methylsterol oxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG25 is a catalytic component of the C-4 demethylation complex that catalyzes the conversion of 4,4-dimethylfecosterol into fecosterol via 4-methylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28…
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

229533:FGSG 02595
gene id: 229533:FGSG_02595
uniprot id: I1RFV4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

229533:FGSG 03652
gene id: 229533:FGSG_03652
uniprot id: I1RIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

229533:FGSG 08670
gene id: 229533:FGSG_08670
uniprot id: I1RWJ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

229533:FGSG 04291
gene id: 229533:FGSG_04291
uniprot id: I1RK95
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

229533:FGSG 10822
gene id: 229533:FGSG_10822
uniprot id: I1S238
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

229533:FGSG 11394
gene id: 229533:FGSG_11394
uniprot id: I1S3K6
names: Function
names: Similarity
messages: Belongs to the peptidase C26 family.
messages: Glutamine amidotransferase-like protein; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).

229533:FGSG 06801
gene id: 229533:FGSG_06801
uniprot id: I1RRR6
names: Similarity
messages: Belongs to the peptidase C48 family.

229533:FGSG 08412
gene id: 229533:FGSG_08412
uniprot id: I1RVW5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 10219
gene id: 229533:FGSG_10219
uniprot id: I1S0J1
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

229533:FGSG 03637
gene id: 229533:FGSG_03637
uniprot id: I1RIK0
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

229533:FGSG 05143
gene id: 229533:FGSG_05143
uniprot id: I1RMF4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

229533:FGSG 01241
gene id: 229533:FGSG_01241
uniprot id: I1RCD4
names: Similarity
messages: Belongs to the 14-3-3 family.

229533:FGSG 06822
gene id: 229533:FGSG_06822
uniprot id: I1RRT3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

229533:FGSG 03124
gene id: 229533:FGSG_03124
uniprot id: I1RH79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

229533:FGSG 02769
gene id: 229533:FGSG_02769
uniprot id: I1RGB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01698
gene id: 229533:FGSG_01698
uniprot id: I1RDJ7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

229533:FGSG 09385
gene id: 229533:FGSG_09385
uniprot id: A0A1I9FLI5
uniprot id: Q4I073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.
messages: Membrane

229533:FGSG 09710
gene id: 229533:FGSG_09710
uniprot id: I1RZ83
names: Similarity
messages: In the C-terminal section; belongs to the DHPS family.

229533:FGSG 13413
gene id: 229533:FGSG_13413
uniprot id: I1S983
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

229533:FGSG 01035
gene id: 229533:FGSG_01035
uniprot id: I1RBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

229533:FGSG 07320
gene id: 229533:FGSG_07320
uniprot id: I1RT28
names: Similarity
messages: Belongs to the GET4 family.

229533:FGSG 12120
gene id: 229533:FGSG_12120
uniprot id: I1S5J9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 01586
gene id: 229533:FGSG_01586
uniprot id: I1RD94
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 04479
gene id: 229533:FGSG_04479
uniprot id: A0A1I9FGN6
uniprot id: Q4IE79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 00583
gene id: 229533:FGSG_00583
uniprot id: I1RAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

229533:FGSG 08066
gene id: 229533:FGSG_08066
uniprot id: I1RV06
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 08830
gene id: 229533:FGSG_08830
uniprot id: I1RWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 09524
gene id: 229533:FGSG_09524
uniprot id: I1RYR6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10312
gene id: 229533:FGSG_10312
uniprot id: I1S0S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

229533:FGSG 01293
gene id: 229533:FGSG_01293
uniprot id: I1RCH8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01785
gene id: 229533:FGSG_01785
uniprot id: I1RDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 03891
gene id: 229533:FGSG_03891
uniprot id: I1RJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10118
gene id: 229533:FGSG_10118
uniprot id: I1S099
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

229533:FGSG 05903
gene id: 229533:FGSG_05903
uniprot id: I1RPD6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

229533:FGSG 13404
gene id: 229533:FGSG_13404
uniprot id: I1S974
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08760
gene id: 229533:FGSG_08760
uniprot id: I1RWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

229533:FGSG 00308
gene id: 229533:FGSG_00308
uniprot id: I1R9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 10992
gene id: 229533:FGSG_10992
uniprot id: I1S2J6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the polysaccharide deacetylase family.
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Leads to reduced virulence and produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.
messages: Peptidoglycan deacetylase-like protein; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).

229533:FGSG 07608
gene id: 229533:FGSG_07608
uniprot id: I1RTU1
names: Similarity
messages: Belongs to the SurE nucleotidase family.

229533:FGSG 00147
gene id: 229533:FGSG_00147
uniprot id: I1R9K3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04923
gene id: 229533:FGSG_04923
uniprot id: I1RLV3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01345
gene id: 229533:FGSG_01345
uniprot id: Q4IN63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).
messages: Cytoplasm
messages: Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
messages: nucleolus

229533:FGSG 03927
gene id: 229533:FGSG_03927
uniprot id: I1RJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

229533:FGSG 10525
gene id: 229533:FGSG_10525
uniprot id: I1S1C5
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 01440
gene id: 229533:FGSG_01440
uniprot id: I1RCV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

229533:FGSG 06270
gene id: 229533:FGSG_06270
uniprot id: I1RQC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

229533:FGSG 03516
gene id: 229533:FGSG_03516
uniprot id: I1RI87
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 02784
gene id: 229533:FGSG_02784
uniprot id: I1RGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

229533:FGSG 06449
gene id: 229533:FGSG_06449
uniprot id: I1RQU9
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 04064
gene id: 229533:FGSG_04064
uniprot id: V6R378
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 05239
gene id: 229533:FGSG_05239
uniprot id: I1RMP5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01059
gene id: 229533:FGSG_01059
uniprot id: A0A1I9EXJ3
uniprot id: Q4INZ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Binds to histones H3 and H4.
messages: Inhibited by both FK506 and rapamycin.
messages: Nucleus
messages: PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.

229533:FGSG 08599
gene id: 229533:FGSG_08599
uniprot id: I1RWD5
names: Similarity
messages: Belongs to the GAMAD family.

229533:FGSG 07102
gene id: 229533:FGSG_07102
uniprot id: I1RSI1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08496
gene id: 229533:FGSG_08496
uniprot id: I1RW42
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10139
gene id: 229533:FGSG_10139
uniprot id: I1S0B7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 00028
gene id: 229533:FGSG_00028
uniprot id: I1R999
names: Function
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Secreted metalloproteinase that allows assimilation of proteinaceous substrates.

229533:FGSG 06048
gene id: 229533:FGSG_06048
uniprot id: I1RPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

229533:FGSG 11955
gene id: 229533:FGSG_11955
uniprot id: A0A1I9EYT1
uniprot id: I1S537
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the velvet family. VeA subfamily.
messages: Component of the heterotrimeric velvet complex composed of laeA, ve1 and velB; Ve1 acting as a bridging protein between laeA and velB (By similarity). Interacts directly with laeA and velB (PubMed:23874628).
messages: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (PubMed:22140571). Controls the expression of the aurofusarin and trichothecene gene clusters (PubMed:22013911). Controls also the expression of the deoxynivalenol (DON) gene cluster (PubMed:22140571). Regulates hyphal growth and pigment formation (PubMed:22140571). Acts as a positive regulator of virulence (PubMed:22013911, PubMed:22140571).
messages: Cytoplasm
messages: Impairs aurofusarin and trichothecene biosynthesis (PubMed:22013911). Reduces deoxynivalenol (DON) biosynthesis (PubMed:22140571). Results in highly reduced sporulation (PubMed:22013911). Reduces the hydrophobicity of the cell surface (PubMed:22140571, PubMed:22013911). Shows increased resistance to osmotic stress and cell wall-damaging agents, but increased sensitivity to iprodione and fludioxonil fungicides (PubMed:22140571, PubMed:22713714).
messages: Nucleus
messages: The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity).

229533:FGSG 07040
gene id: 229533:FGSG_07040
uniprot id: I1RSC4
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 03462
gene id: 229533:FGSG_03462
uniprot id: I1RI39
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.

229533:FGSG 01141
gene id: 229533:FGSG_01141
uniprot id: I1RC39
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 06006
gene id: 229533:FGSG_06006
uniprot id: I1RPN1
names: Similarity
messages: Belongs to the frataxin family.

229533:FGSG 09197
gene id: 229533:FGSG_09197
uniprot id: I1RXX1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.

229533:FGSG 09978
gene id: 229533:FGSG_09978
uniprot id: A0A1I9F447
uniprot id: Q4HYI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the 7-subunit TFIIH core complex.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

229533:FGSG 08929
gene id: 229533:FGSG_08929
uniprot id: V6RIS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

229533:FGSG 05164
gene id: 229533:FGSG_05164
uniprot id: I1RMH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 03714
gene id: 229533:FGSG_03714
uniprot id: I1RIS0
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

229533:FGSG 08495
gene id: 229533:FGSG_08495
uniprot id: I1RW41
names: Similarity
messages: Belongs to the nuclease type I family.

229533:FGSG 08150
gene id: 229533:FGSG_08150
uniprot id: I1RV85
names: Similarity
messages: Belongs to the lysophospholipase family.

229533:FGSG 10033
gene id: 229533:FGSG_10033
uniprot id: I1S021
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

229533:FGSG 10782
gene id: 229533:FGSG_10782
uniprot id: I1S202
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 04973
gene id: 229533:FGSG_04973
uniprot id: I1RM01
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

229533:FGSG 12742
gene id: 229533:FGSG_12742
uniprot id: I1S7B9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01515
gene id: 229533:FGSG_01515
uniprot id: I1RD28
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07402
gene id: 229533:FGSG_07402
uniprot id: I1RTA1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

229533:FGSG 02676
gene id: 229533:FGSG_02676
uniprot id: I1RG27
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04480
gene id: 229533:FGSG_04480
uniprot id: I1RKR4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07292
gene id: 229533:FGSG_07292
uniprot id: I1RT04
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

229533:FGSG 01510
gene id: 229533:FGSG_01510
uniprot id: I1RD23
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

229533:FGSG 12534
gene id: 229533:FGSG_12534
uniprot id: I1S6R1
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 06611
gene id: 229533:FGSG_06611
uniprot id: I1RR95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

229533:FGSG 13127
gene id: 229533:FGSG_13127
uniprot id: I1S8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 07093
gene id: 229533:FGSG_07093
uniprot id: I1RSH4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

229533:FGSG 00732
gene id: 229533:FGSG_00732
uniprot id: I1RB27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

229533:FGSG 10157
gene id: 229533:FGSG_10157
uniprot id: I1S0D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.
messages: Nucleus

229533:FGSG 01857
gene id: 229533:FGSG_01857
uniprot id: I1RDY8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 03212
gene id: 229533:FGSG_03212
uniprot id: I1RHG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

229533:FGSG 08660
gene id: 229533:FGSG_08660
uniprot id: Q4I298
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
messages: Homopentamer. Forms homooligomers. Interacts with MFM1.
messages: Mitochondrion inner membrane

229533:FGSG 00200
gene id: 229533:FGSG_00200
uniprot id: I1R9P7
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 09511
gene id: 229533:FGSG_09511
uniprot id: I1RYQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane

229533:FGSG 10145
gene id: 229533:FGSG_10145
uniprot id: I1S0C3
names: Similarity
messages: Belongs to the peptidase S10 family.

229533:FGSG 01655
gene id: 229533:FGSG_01655
uniprot id: I1RDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 10227
gene id: 229533:FGSG_10227
uniprot id: I1S0J8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

229533:FGSG 10261
gene id: 229533:FGSG_10261
uniprot id: I1S0M8
names: Similarity
messages: Belongs to the ADIP family.

229533:FGSG 10742
gene id: 229533:FGSG_10742
uniprot id: I1S1W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 10561
gene id: 229533:FGSG_10561
uniprot id: I1S1G0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

229533:FGSG 05614
gene id: 229533:FGSG_05614
uniprot id: I1RNN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 08039
gene id: 229533:FGSG_08039
uniprot id: I1RUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 08840
gene id: 229533:FGSG_08840
uniprot id: I1RWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

229533:FGSG 00227
gene id: 229533:FGSG_00227
uniprot id: I1R9S1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 13708
gene id: 229533:FGSG_13708
uniprot id: I1SA27
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

229533:FGSG 00912
gene id: 229533:FGSG_00912
uniprot id: I1RBI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

229533:FGSG 10706
gene id: 229533:FGSG_10706
uniprot id: I1S1T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 10117
gene id: 229533:FGSG_10117
uniprot id: I1S098
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 03780
gene id: 229533:FGSG_03780
uniprot id: I1RIY3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Leads to no variable phenotypes.
messages: Membrane
messages: Probable water/glycerol channel that may have redundant functions with FgAQP2.

229533:FGSG 03369
gene id: 229533:FGSG_03369
uniprot id: I1RHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06533
gene id: 229533:FGSG_06533
uniprot id: I1RR26
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03219
gene id: 229533:FGSG_03219
uniprot id: I1RHG6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10938
gene id: 229533:FGSG_10938
uniprot id: I1S2E6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01803
gene id: 229533:FGSG_01803
uniprot id: I1RDT7
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase.
messages: Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.

229533:FGSG 13830
gene id: 229533:FGSG_13830
uniprot id: I1SAE9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05249
gene id: 229533:FGSG_05249
uniprot id: I1RMQ4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

229533:FGSG 00118
gene id: 229533:FGSG_00118
uniprot id: I1R9H7
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 03127
gene id: 229533:FGSG_03127
uniprot id: I1RH82
names: Similarity
messages: Belongs to the FBPase class 1 family.

229533:FGSG 10148
gene id: 229533:FGSG_10148
uniprot id: I1S0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

229533:FGSG 10516
gene id: 229533:FGSG_10516
uniprot id: I1S1B6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

229533:FGSG 10343
gene id: 229533:FGSG_10343
uniprot id: I1S0V3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular space

229533:FGSG 01332
gene id: 229533:FGSG_01332
uniprot id: I1RCL3
names: Similarity
messages: Belongs to the CBF/MAK21 family.

229533:FGSG 08911
gene id: 229533:FGSG_08911
uniprot id: I1RX61
names: Similarity
messages: Belongs to the chloroperoxidase family.

229533:FGSG 10463
gene id: 229533:FGSG_10463
uniprot id: I1S165
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Abolishes the production of fusarielins F, G and H.
messages: Belongs to the LovG family.
messages: Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes.
messages: Thioesterase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606).

229533:FGSG 10080
gene id: 229533:FGSG_10080
uniprot id: I1S064
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

229533:FGSG 02171
gene id: 229533:FGSG_02171
uniprot id: I1RES1
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 10528
gene id: 229533:FGSG_10528
uniprot id: I1S1C8
names: Subcellular Location Annotation
messages: cytoskeleton

229533:FGSG 05554
gene id: 229533:FGSG_05554
uniprot id: I1RNH4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 05072
gene id: 229533:FGSG_05072
uniprot id: A0A1I9FVL9
uniprot id: Q4ICI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: cis-Golgi network membrane

229533:FGSG 11698
gene id: 229533:FGSG_11698
uniprot id: I1S4D1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

229533:FGSG 08265
gene id: 229533:FGSG_08265
uniprot id: I1RVI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 09110
gene id: 229533:FGSG_09110
uniprot id: I1RXN6
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 02031
gene id: 229533:FGSG_02031
uniprot id: I1REE3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08777
gene id: 229533:FGSG_08777
uniprot id: Q4I1Y1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

229533:FGSG 05839
gene id: 229533:FGSG_05839
uniprot id: I1RP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00740
gene id: 229533:FGSG_00740
uniprot id: I1RB35
names: Cofactor
names: PTM
names: Similarity
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.

229533:FGSG 05448
gene id: 229533:FGSG_05448
uniprot id: I1RN82
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08655
gene id: 229533:FGSG_08655
uniprot id: I1RWI5
names: Similarity
messages: Belongs to the eIF-1A family.

229533:FGSG 01052
gene id: 229533:FGSG_01052
uniprot id: I1RBW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

229533:FGSG 05513
gene id: 229533:FGSG_05513
uniprot id: I1RND9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Involved in spliceosome maturation and the first step of pre-mRNA splicing.
messages: Nucleus

229533:FGSG 05218
gene id: 229533:FGSG_05218
uniprot id: I1RMM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

229533:FGSG 10660
gene id: 229533:FGSG_10660
uniprot id: I1S1P9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10187
gene id: 229533:FGSG_10187
uniprot id: I1S0G1
names: Similarity
messages: Belongs to the sorting nexin family.

229533:FGSG 03855
gene id: 229533:FGSG_03855
uniprot id: I1RJ52
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05916
gene id: 229533:FGSG_05916
uniprot id: V6RCG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

229533:FGSG 05153
gene id: 229533:FGSG_05153
uniprot id: I1RMG3
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 05527
gene id: 229533:FGSG_05527
uniprot id: I1RNF1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01559
gene id: 229533:FGSG_01559
uniprot id: I1RD70
names: Subcellular Location Annotation
messages: Membrane
messages: Preautophagosomal structure membrane

229533:FGSG 04780
gene id: 229533:FGSG_04780
uniprot id: I1RLH8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01086
gene id: 229533:FGSG_01086
uniprot id: I1RBY9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

229533:FGSG 02787
gene id: 229533:FGSG_02787
uniprot id: I1RGC8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09312
gene id: 229533:FGSG_09312
uniprot id: I1RY74
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

229533:FGSG 05119
gene id: 229533:FGSG_05119
uniprot id: I1RMD0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06669
gene id: 229533:FGSG_06669
uniprot id: I1RRE9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03181
gene id: 229533:FGSG_03181
uniprot id: I1RHD4
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 05091
gene id: 229533:FGSG_05091
uniprot id: I1RMA5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03847
gene id: 229533:FGSG_03847
uniprot id: I1RJ46
names: Similarity
messages: Belongs to the TMEM14 family.

229533:FGSG 04906
gene id: 229533:FGSG_04906
uniprot id: I1RLT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Lysosome membrane
messages: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.

229533:FGSG 07685
gene id: 229533:FGSG_07685
uniprot id: I1RU11
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 10166
gene id: 229533:FGSG_10166
uniprot id: I1S0E2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Functions to maintain conidial dormancy by suppressing microcycle conidiation (PubMed:24186953).
messages: Belongs to the wetA family.
messages: Expression is positively regulated by flbD (PubMed:25277408).
messages: Results in abnormal production of conidiophores and conidia, including longer conidia with fewer septa, conidia sensitivity to acute stresses such as oxidative stress and heat stress, and vigorous generation of single-celled conidia through autophagy-dependent microcycle conidiation (PubMed:24186953). Reduces the survival rate of aged conidia (PubMed:24186953).

229533:FGSG 01314
gene id: 229533:FGSG_01314
uniprot id: I1RCJ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

229533:FGSG 01390
gene id: 229533:FGSG_01390
uniprot id: I1RCR4
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 05851
gene id: 229533:FGSG_05851
uniprot id: I1RP94
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

229533:FGSG 00590
gene id: 229533:FGSG_00590
uniprot id: I1RAQ5
names: Similarity
messages: Belongs to the TPA1 family.

229533:FGSG 09306
gene id: 229533:FGSG_09306
uniprot id: I1RY69
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09080
gene id: 229533:FGSG_09080
uniprot id: I1RXK9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11342
gene id: 229533:FGSG_11342
uniprot id: I1S3G1
names: Similarity
messages: Belongs to the CIA30 family.

229533:FGSG 07543
gene id: 229533:FGSG_07543
uniprot id: I1RTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00998
gene id: 229533:FGSG_00998
uniprot id: I1RBR2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

229533:FGSG 09287
gene id: 229533:FGSG_09287
uniprot id: I1RY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 12767
gene id: 229533:FGSG_12767
uniprot id: I1S7E4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 10180
gene id: 229533:FGSG_10180
uniprot id: V6RXW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

229533:FGSG 00926
gene id: 229533:FGSG_00926
uniprot id: I1RBK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane

229533:FGSG 02510
gene id: 229533:FGSG_02510
uniprot id: I1RFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

229533:FGSG 03858
gene id: 229533:FGSG_03858
uniprot id: I1RJ55
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 04235
gene id: 229533:FGSG_04235
uniprot id: I1RK47
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

229533:FGSG 06191
gene id: 229533:FGSG_06191
uniprot id: A0A1I9FUF1
uniprot id: Q4I9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts with microtubules.
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.
messages: Nucleus
messages: cytoskeleton
messages: spindle

229533:FGSG 04611
gene id: 229533:FGSG_04611
uniprot id: I1RL31
names: Similarity
messages: Belongs to the DeSI family.

229533:FGSG 05436
gene id: 229533:FGSG_05436
uniprot id: I1RN70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

229533:FGSG 07953
gene id: 229533:FGSG_07953
uniprot id: I1RUQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

229533:FGSG 05415
gene id: 229533:FGSG_05415
uniprot id: I1RN51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

229533:FGSG 01013
gene id: 229533:FGSG_01013
uniprot id: I1RBS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

229533:FGSG 10766
gene id: 229533:FGSG_10766
uniprot id: I1S1Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

229533:FGSG 10444
gene id: 229533:FGSG_10444
uniprot id: I1S147
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

229533:FGSG 08942
gene id: 229533:FGSG_08942
uniprot id: V6RK40
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 05653
gene id: 229533:FGSG_05653
uniprot id: I1RNR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

229533:FGSG 01407
gene id: 229533:FGSG_01407
uniprot id: I1RCT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

229533:FGSG 04717
gene id: 229533:FGSG_04717
uniprot id: I1RLC6
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 07547
gene id: 229533:FGSG_07547
uniprot id: A0A1I9FR99
uniprot id: Q4I5G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

229533:FGSG 02386
gene id: 229533:FGSG_02386
uniprot id: I1RFB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

229533:FGSG 04277
gene id: 229533:FGSG_04277
uniprot id: I1RK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

229533:FGSG 13446
gene id: 229533:FGSG_13446
uniprot id: I1S9B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

229533:FGSG 03599
gene id: 229533:FGSG_03599
uniprot id: I1RIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 05409
gene id: 229533:FGSG_05409
uniprot id: I1RN46
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

229533:FGSG 02266
gene id: 229533:FGSG_02266
uniprot id: I1RF04
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 04385
gene id: 229533:FGSG_04385
uniprot id: I1RKI1
names: Similarity
messages: Belongs to the actin family.

229533:FGSG 01392
gene id: 229533:FGSG_01392
uniprot id: I1RCR6
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

229533:FGSG 05640
gene id: 229533:FGSG_05640
uniprot id: I1RNQ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

229533:FGSG 02852
gene id: 229533:FGSG_02852
uniprot id: I1RGI5
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

229533:FGSG 11439
gene id: 229533:FGSG_11439
uniprot id: I1S3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

229533:FGSG 03633
gene id: 229533:FGSG_03633
uniprot id: I1RIJ6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

229533:FGSG 06819
gene id: 229533:FGSG_06819
uniprot id: V6REW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

229533:FGSG 10375
gene id: 229533:FGSG_10375
uniprot id: I1S0Y3
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 03140
gene id: 229533:FGSG_03140
uniprot id: I1RH95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05042
gene id: 229533:FGSG_05042
uniprot id: V6R9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05674
gene id: 229533:FGSG_05674
uniprot id: I1RNT5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08466
gene id: 229533:FGSG_08466
uniprot id: I1RW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

229533:FGSG 00806
gene id: 229533:FGSG_00806
uniprot id: I1RB96
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 11066
gene id: 229533:FGSG_11066
uniprot id: I1S2R5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 09803
gene id: 229533:FGSG_09803
uniprot id: I1RZG3
names: Similarity
messages: Belongs to the TTC4 family.

229533:FGSG 00189
gene id: 229533:FGSG_00189
uniprot id: I1R9N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

229533:FGSG 11143
gene id: 229533:FGSG_11143
uniprot id: I1S2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 4 family.
messages: Secreted

229533:FGSG 07849
gene id: 229533:FGSG_07849
uniprot id: I1RUF8
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

229533:FGSG 07404
gene id: 229533:FGSG_07404
uniprot id: I1RTA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

229533:FGSG 05859
gene id: 229533:FGSG_05859
uniprot id: I1RPA1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03349
gene id: 229533:FGSG_03349
uniprot id: I1RHT5
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 07209
gene id: 229533:FGSG_07209
uniprot id: V6RGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

229533:FGSG 08668
gene id: 229533:FGSG_08668
uniprot id: I1RWJ6
names: Similarity
messages: Belongs to the peptidase C12 family.

229533:FGSG 06859
gene id: 229533:FGSG_06859
uniprot id: I1RRW2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

229533:FGSG 07516
gene id: 229533:FGSG_07516
uniprot id: I1RTK7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08596
gene id: 229533:FGSG_08596
uniprot id: I1RWD2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 07470
gene id: 229533:FGSG_07470
uniprot id: I1RTG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 08995
gene id: 229533:FGSG_08995
uniprot id: I1RXC9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

229533:FGSG 05127
gene id: 229533:FGSG_05127
uniprot id: I1RMD8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01499
gene id: 229533:FGSG_01499
uniprot id: I1RD12
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01885
gene id: 229533:FGSG_01885
uniprot id: I1RE13
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03882
gene id: 229533:FGSG_03882
uniprot id: I1RJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 06160
gene id: 229533:FGSG_06160
uniprot id: I1RQ27
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01931
gene id: 229533:FGSG_01931
uniprot id: I1RE57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

229533:FGSG 03247
gene id: 229533:FGSG_03247
uniprot id: V6RDP1
names: Similarity
messages: Belongs to the FGGY kinase family.

229533:FGSG 02139
gene id: 229533:FGSG_02139
uniprot id: I1REP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

229533:FGSG 06737
gene id: 229533:FGSG_06737
uniprot id: A0A1I9FL67
uniprot id: Q4I7S1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAF9 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The coiled-coil domain is required for assembly into the NuA4 complex.

229533:FGSG 09568
gene id: 229533:FGSG_09568
uniprot id: I1RYV7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05480
gene id: 229533:FGSG_05480
uniprot id: I1RNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Mitochondrion

229533:FGSG 02233
gene id: 229533:FGSG_02233
uniprot id: I1REX4
names: Subcellular Location Annotation
messages: cytoskeleton

229533:FGSG 02600
gene id: 229533:FGSG_02600
uniprot id: I1RFV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 09331
gene id: 229533:FGSG_09331
uniprot id: I1RY91
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03803
gene id: 229533:FGSG_03803
uniprot id: I1RJ05
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

229533:FGSG 02743
gene id: 229533:FGSG_02743
uniprot id: I1RG87
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01208
gene id: 229533:FGSG_01208
uniprot id: I1RCA5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

229533:FGSG 13369
gene id: 229533:FGSG_13369
uniprot id: I1S939
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 07576
gene id: 229533:FGSG_07576
uniprot id: I1RTR2
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 08797
gene id: 229533:FGSG_08797
uniprot id: I1RWW1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

229533:FGSG 13433
gene id: 229533:FGSG_13433
uniprot id: I1S9A3
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 00443
gene id: 229533:FGSG_00443
uniprot id: I1RAB6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

229533:FGSG 11218
gene id: 229533:FGSG_11218
uniprot id: I1S353
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05245
gene id: 229533:FGSG_05245
uniprot id: I1RMQ1
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 09163
gene id: 229533:FGSG_09163
uniprot id: I1RXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 10236
gene id: 229533:FGSG_10236
uniprot id: V6RQR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

229533:FGSG 09690
gene id: 229533:FGSG_09690
uniprot id: Q4HZB8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Cytoplasm
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

229533:FGSG 00739
gene id: 229533:FGSG_00739
uniprot id: I1RB34
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11495
gene id: 229533:FGSG_11495
uniprot id: I1S3U7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 01842
gene id: 229533:FGSG_01842
uniprot id: I1RDX3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

229533:FGSG 00145
gene id: 229533:FGSG_00145
uniprot id: I1R9K2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

229533:FGSG 00361
gene id: 229533:FGSG_00361
uniprot id: I1RA38
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01918
gene id: 229533:FGSG_01918
uniprot id: I1RE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

229533:FGSG 12678
gene id: 229533:FGSG_12678
uniprot id: I1S755
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

229533:FGSG 01373
gene id: 229533:FGSG_01373
uniprot id: I1RCP9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01018
gene id: 229533:FGSG_01018
uniprot id: I1RBS8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

229533:FGSG 05687
gene id: 229533:FGSG_05687
uniprot id: A0A1I9FVW7
uniprot id: Q4IAS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 03027
gene id: 229533:FGSG_03027
uniprot id: I1RGZ4
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 03813
gene id: 229533:FGSG_03813
uniprot id: I1RJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 54 family.
messages: Secreted

229533:FGSG 00340
gene id: 229533:FGSG_00340
uniprot id: A0A1I9EV20
uniprot id: Q4IR18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Polynucleotide 5'-kinase involved in rRNA processing.
messages: nucleolus

229533:FGSG 08946
gene id: 229533:FGSG_08946
uniprot id: I1RX92
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 03133
gene id: 229533:FGSG_03133
uniprot id: I1RH88
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00359
gene id: 229533:FGSG_00359
uniprot id: V6QV09
names: Similarity
messages: Belongs to the cullin family.

229533:FGSG 12421
gene id: 229533:FGSG_12421
uniprot id: I1S6F0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 02099
gene id: 229533:FGSG_02099
uniprot id: I1REK8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

229533:FGSG 00068
gene id: 229533:FGSG_00068
uniprot id: I1R9D3
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase.
messages: Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.

229533:FGSG 09515
gene id: 229533:FGSG_09515
uniprot id: I1RYQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 10856
gene id: 229533:FGSG_10856
uniprot id: I1S270
names: Similarity
messages: Belongs to the actin family.

229533:FGSG 02608
gene id: 229533:FGSG_02608
uniprot id: I1RFW6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03994
gene id: 229533:FGSG_03994
uniprot id: I1RJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 08816
gene id: 229533:FGSG_08816
uniprot id: I1RWX9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 12142
gene id: 229533:FGSG_12142
uniprot id: I1S5M1
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

229533:FGSG 08174
gene id: 229533:FGSG_08174
uniprot id: I1RVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 03972
gene id: 229533:FGSG_03972
uniprot id: I1RJF6
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 00836
gene id: 229533:FGSG_00836
uniprot id: I1RBC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.

229533:FGSG 05197
gene id: 229533:FGSG_05197
uniprot id: I1RMK6
names: Similarity
messages: Belongs to the SELO family.

229533:FGSG 02220
gene id: 229533:FGSG_02220
uniprot id: V6QZ48
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 05238
gene id: 229533:FGSG_05238
uniprot id: I1RMP4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02625
gene id: 229533:FGSG_02625
uniprot id: I1RFY1
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

229533:FGSG 11322
gene id: 229533:FGSG_11322
uniprot id: I1S3E4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00556
gene id: 229533:FGSG_00556
uniprot id: I1RAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space
messages: Required for the assembly of cytochrome c oxidase.

229533:FGSG 08445
gene id: 229533:FGSG_08445
uniprot id: I1RVZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

229533:FGSG 09065
gene id: 229533:FGSG_09065
uniprot id: I1RXJ4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04352
gene id: 229533:FGSG_04352
uniprot id: I1RKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 09518
gene id: 229533:FGSG_09518
uniprot id: I1RYR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DUO1 family.
messages: Nucleus
messages: kinetochore

229533:FGSG 03777
gene id: 229533:FGSG_03777
uniprot id: I1RIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
messages: Cytoplasm
messages: Homodimer.

229533:FGSG 02780
gene id: 229533:FGSG_02780
uniprot id: I1RGC1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

229533:FGSG 02000
gene id: 229533:FGSG_02000
uniprot id: I1REB4
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 12193
gene id: 229533:FGSG_12193
uniprot id: I1S5S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

229533:FGSG 00136
gene id: 229533:FGSG_00136
uniprot id: I1R9J4
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 04186
gene id: 229533:FGSG_04186
uniprot id: I1RK02
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

229533:FGSG 05053
gene id: 229533:FGSG_05053
uniprot id: I1RM70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00665
gene id: 229533:FGSG_00665
uniprot id: I1RAX1
names: Function
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.

229533:FGSG 06318
gene id: 229533:FGSG_06318
uniprot id: I1RQH5
names: Similarity
messages: Belongs to the BolA/IbaG family.

229533:FGSG 04832
gene id: 229533:FGSG_04832
uniprot id: I1RLM5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 04253
gene id: 229533:FGSG_04253
uniprot id: A0A1I9FEZ4
uniprot id: Q4IEV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.
messages: Nucleus

229533:FGSG 02041
gene id: 229533:FGSG_02041
uniprot id: I1REF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 09291
gene id: 229533:FGSG_09291
uniprot id: V6RMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 11028
gene id: 229533:FGSG_11028
uniprot id: I1S2M9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02541
gene id: 229533:FGSG_02541
uniprot id: V6R042
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

229533:FGSG 08552
gene id: 229533:FGSG_08552
uniprot id: I1RW91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 06705
gene id: 229533:FGSG_06705
uniprot id: I1RRI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

229533:FGSG 06198
gene id: 229533:FGSG_06198
uniprot id: I1RQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

229533:FGSG 06100
gene id: 229533:FGSG_06100
uniprot id: I1RPW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 11504
gene id: 229533:FGSG_11504
uniprot id: I1S3V6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11978
gene id: 229533:FGSG_11978
uniprot id: I1S560
names: Similarity
messages: Belongs to the TCP11 family.

229533:FGSG 08909
gene id: 229533:FGSG_08909
uniprot id: I1RX59
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

229533:FGSG 07405
gene id: 229533:FGSG_07405
uniprot id: A0A1I9FHS6
uniprot id: Q4I5V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

229533:FGSG 09739
gene id: 229533:FGSG_09739
uniprot id: I1RZA7
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

229533:FGSG 09918
gene id: 229533:FGSG_09918
uniprot id: I1RZR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

229533:FGSG 04065
gene id: 229533:FGSG_04065
uniprot id: I1RJN7
names: Similarity
messages: Belongs to the transketolase family.

229533:FGSG 09191
gene id: 229533:FGSG_09191
uniprot id: I1RXW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

229533:FGSG 10941
gene id: 229533:FGSG_10941
uniprot id: I1S2E9
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

229533:FGSG 02367
gene id: 229533:FGSG_02367
uniprot id: I1RF98
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 11405
gene id: 229533:FGSG_11405
uniprot id: I1S3L6
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 03246
gene id: 229533:FGSG_03246
uniprot id: I1RHJ0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02751
gene id: 229533:FGSG_02751
uniprot id: I1RG95
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

229533:FGSG 04666
gene id: 229533:FGSG_04666
uniprot id: I1RL82
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06265
gene id: 229533:FGSG_06265
uniprot id: I1RQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.

229533:FGSG 06690
gene id: 229533:FGSG_06690
uniprot id: I1RRG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

229533:FGSG 01863
gene id: 229533:FGSG_01863
uniprot id: I1RDZ4
names: Similarity
messages: Belongs to the peptidase C12 family.

229533:FGSG 02494
gene id: 229533:FGSG_02494
uniprot id: A0A1I9F1Z0
uniprot id: Q4IJW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

229533:FGSG 06588
gene id: 229533:FGSG_06588
uniprot id: I1RR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: centrosome
messages: sarcomere
messages: stress fiber

229533:FGSG 08016
gene id: 229533:FGSG_08016
uniprot id: I1RUV9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06203
gene id: 229533:FGSG_06203
uniprot id: I1RQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

229533:FGSG 08407
gene id: 229533:FGSG_08407
uniprot id: I1RVW1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 08607
gene id: 229533:FGSG_08607
uniprot id: I1RWE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

229533:FGSG 04262
gene id: 229533:FGSG_04262
uniprot id: I1RK69
names: Similarity
messages: Belongs to the asteroid family.

229533:FGSG 04319
gene id: 229533:FGSG_04319
uniprot id: I1RKB9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01643
gene id: 229533:FGSG_01643
uniprot id: I1RDE7
names: Similarity
messages: Belongs to the chorismate synthase family.

229533:FGSG 03463
gene id: 229533:FGSG_03463
uniprot id: I1RI40
names: Similarity
messages: Belongs to the tpcK family.

229533:FGSG 12878
gene id: 229533:FGSG_12878
uniprot id: I1S7Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDI1 family.
messages: Binds ubiquitin and polyubiquitinated proteins.
messages: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

229533:FGSG 02091
gene id: 229533:FGSG_02091
uniprot id: I1REK2
names: Similarity
messages: Belongs to the DCP1 family.

229533:FGSG 11897
gene id: 229533:FGSG_11897
uniprot id: I1S4X9
names: Similarity
messages: Belongs to the NAD kinase family.

229533:FGSG 11636
gene id: 229533:FGSG_11636
uniprot id: I1S471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

229533:FGSG 01802
gene id: 229533:FGSG_01802
uniprot id: I1RDT6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 00648
gene id: 229533:FGSG_00648
uniprot id: I1RAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD3 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 07174
gene id: 229533:FGSG_07174
uniprot id: I1RSP6
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

229533:FGSG 00482
gene id: 229533:FGSG_00482
uniprot id: A0A1I9EVI6
uniprot id: Q4IQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS4/SLD5 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).

229533:FGSG 09052
gene id: 229533:FGSG_09052
uniprot id: I1RXI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00712
gene id: 229533:FGSG_00712
uniprot id: V6QW87
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 12631
gene id: 229533:FGSG_12631
uniprot id: I1S708
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02710
gene id: 229533:FGSG_02710
uniprot id: I1RG61
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

229533:FGSG 08053
gene id: 229533:FGSG_08053
uniprot id: I1RUZ3
names: Similarity
messages: Belongs to the sulfatase family.

229533:FGSG 08509
gene id: 229533:FGSG_08509
uniprot id: I1RW54
names: Similarity
messages: Belongs to the AccD/PCCB family.

229533:FGSG 04685
gene id: 229533:FGSG_04685
uniprot id: I1RL99
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 13661
gene id: 229533:FGSG_13661
uniprot id: I1S9Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 08824
gene id: 229533:FGSG_08824
uniprot id: I1RWY4
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 01731
gene id: 229533:FGSG_01731
uniprot id: I1RDM2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05403
gene id: 229533:FGSG_05403
uniprot id: Q4IBK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
messages: Nucleus

229533:FGSG 08044
gene id: 229533:FGSG_08044
uniprot id: I1RUY5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

229533:FGSG 07319
gene id: 229533:FGSG_07319
uniprot id: I1RT27
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 06444
gene id: 229533:FGSG_06444
uniprot id: I1RQU4
names: Similarity
messages: Belongs to the trichodiene synthase family.

229533:FGSG 05174
gene id: 229533:FGSG_05174
uniprot id: I1RMI4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

229533:FGSG 12461
gene id: 229533:FGSG_12461
uniprot id: I1S6J0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

229533:FGSG 03414
gene id: 229533:FGSG_03414
uniprot id: I1RHZ5
names: Similarity
messages: Belongs to the GcvT family.

229533:FGSG 09255
gene id: 229533:FGSG_09255
uniprot id: A0A1I9FQG2
uniprot id: Q4I0K3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
messages: Membrane

229533:FGSG 05571
gene id: 229533:FGSG_05571
uniprot id: I1RNJ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04914
gene id: 229533:FGSG_04914
uniprot id: I1RLU5
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 07004
gene id: 229533:FGSG_07004
uniprot id: I1RS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Endomembrane system
messages: Vacuole membrane

229533:FGSG 12442
gene id: 229533:FGSG_12442
uniprot id: I1S6H1
names: Similarity
messages: Belongs to the amidase family.

229533:FGSG 05314
gene id: 229533:FGSG_05314
uniprot id: A0A1I9FY03
uniprot id: Q4IBU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

229533:FGSG 03632
gene id: 229533:FGSG_03632
uniprot id: I1RIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 08845
gene id: 229533:FGSG_08845
uniprot id: I1RX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

229533:FGSG 09981
gene id: 229533:FGSG_09981
uniprot id: I1RZX5
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 04470
gene id: 229533:FGSG_04470
uniprot id: I1RKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

229533:FGSG 01372
gene id: 229533:FGSG_01372
uniprot id: I1RCP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

229533:FGSG 02151
gene id: 229533:FGSG_02151
uniprot id: I1REQ6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11915
gene id: 229533:FGSG_11915
uniprot id: I1S4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.

229533:FGSG 05518
gene id: 229533:FGSG_05518
uniprot id: I1RNE4
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

229533:FGSG 05320
gene id: 229533:FGSG_05320
uniprot id: I1RMW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

229533:FGSG 04544
gene id: 229533:FGSG_04544
uniprot id: I1RKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 12335
gene id: 229533:FGSG_12335
uniprot id: I1S664
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11559
gene id: 229533:FGSG_11559
uniprot id: I1S407
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 04431
gene id: 229533:FGSG_04431
uniprot id: I1RKM0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01919
gene id: 229533:FGSG_01919
uniprot id: A0A1I9F0D0
uniprot id: Q4ILI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.

229533:FGSG 03904
gene id: 229533:FGSG_03904
uniprot id: I1RJ96
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

229533:FGSG 00087
gene id: 229533:FGSG_00087
uniprot id: I1R9F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01538
gene id: 229533:FGSG_01538
uniprot id: A0A1I9EZ89
uniprot id: Q4IMM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

229533:FGSG 02324
gene id: 229533:FGSG_02324
uniprot id: I1RF58
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721). Expression is negatively regulated by the MAPK-mediated osmotic stress-signaling pathway (PubMed:17897620). Expression is also regulated by the CID1 cyclin C-like protein (PubMed:19909822).
messages: Leads to a albinos phanotype and affects conidiation (PubMed:15811992, PubMed:16278459, PubMed:15809006, PubMed:15780665).
messages: Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (By similarity).
messages: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:16278459, PubMed:15809006, PubMed:15780665, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: The C-terminal region is involved in Claisen-type cyclization of the second ring of naphthopyrone.

229533:FGSG 01920
gene id: 229533:FGSG_01920
uniprot id: I1RE46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

229533:FGSG 11219
gene id: 229533:FGSG_11219
uniprot id: I1S354
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11603
gene id: 229533:FGSG_11603
uniprot id: V6R227
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 04659
gene id: 229533:FGSG_04659
uniprot id: I1RL76
names: Similarity
messages: Belongs to the DSD1 family.

229533:FGSG 03385
gene id: 229533:FGSG_03385
uniprot id: I1RHW9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

229533:FGSG 05111
gene id: 229533:FGSG_05111
uniprot id: I1RMC2
names: Function
names: Similarity
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

229533:FGSG 07182
gene id: 229533:FGSG_07182
uniprot id: I1RSQ4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

229533:FGSG 05379
gene id: 229533:FGSG_05379
uniprot id: I1RN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01027
gene id: 229533:FGSG_01027
uniprot id: I1RBT7
names: Similarity
messages: Belongs to the cytochrome b5 family.

229533:FGSG 05648
gene id: 229533:FGSG_05648
uniprot id: I1RNR2
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

229533:FGSG 07255
gene id: 229533:FGSG_07255
uniprot id: V6RGB5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

229533:FGSG 03535
gene id: 229533:FGSG_03535
uniprot id: I1RIA5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 11845
gene id: 229533:FGSG_11845
uniprot id: I1S4S7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

229533:FGSG 05405
gene id: 229533:FGSG_05405
uniprot id: I1RN42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

229533:FGSG 09810
gene id: 229533:FGSG_09810
uniprot id: I1RZG9
names: Similarity
messages: Belongs to the HIT family.

229533:FGSG 06051
gene id: 229533:FGSG_06051
uniprot id: I1RPS2
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

229533:FGSG 07200
gene id: 229533:FGSG_07200
uniprot id: I1RSR9
names: Similarity
messages: Belongs to the activator 1 small subunits family.

229533:FGSG 02145
gene id: 229533:FGSG_02145
uniprot id: I1REQ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13166
gene id: 229533:FGSG_13166
uniprot id: I1S8I8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 10680
gene id: 229533:FGSG_10680
uniprot id: I1S1R5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 09586
gene id: 229533:FGSG_09586
uniprot id: I1RYX4
names: Function
names: Subunit
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

229533:FGSG 05016
gene id: 229533:FGSG_05016
uniprot id: V6RAC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Mitochondrion

229533:FGSG 00625
gene id: 229533:FGSG_00625
uniprot id: I1RAT9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11846
gene id: 229533:FGSG_11846
uniprot id: I1S4S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00461
gene id: 229533:FGSG_00461
uniprot id: I1RAD4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13972
gene id: 229533:FGSG_13972
uniprot id: I1SAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 10003
gene id: 229533:FGSG_10003
uniprot id: I1RZZ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Abolishes the production of ergosterol and leads to the accumulation of sterol intermediates (PubMed:22947191). Leads to reduced deoxynivalenol (DON) production (PubMed:22947191). Results in reduced mycelial growth as well as less conidia (PubMed:22947191). Leads to decreased virulence (PubMed:22947191). Exhibits a significantly increased sensitivity to the divalent cations Cu(2+), Mg(2+) and Ca(2+), as well as to the trivalent cations Fe(3+) and Al(3+) (PubMed:22947191). Shows increased resistance to cell wall-degrading enzymes and significantly increases sensitivity to osmotic stress mediated by NaCl and D-sorbitol, and to oxidative stress generated by H(2)O(2) and paraquat (PubMed:22947191). Decreases tolerance to sterol biosynthesis inhibitors, including triadimefon and tebuconazole (targeting sterol 14-alpha-demethylase), the amine fungicides tridemorph, fenpropidin and spiroxamine (targeting sterol C-14 reductase or sterol delta-7,8-isomerase) and the polyene fungicides nystatin and amphotericin B (binding to ergosterol) (PubMed:22947191). Does not affect the sensitivity to the dicarboximide fungicide iprodione (PubMed:22947191). Finally, ERG4 deletion leads to increased expression of the ergosterol biosynthesis genes CYP51A, CYP51B, CYP51C, ERG2, ERG6A, ERG6B, ERG7, ERG24A and ERG24B (PubMed:22947191).
messages: Belongs to the ERG4/ERG24 family.
messages: Delta(24(24(1)))-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:22947191). ERG4 catalyzes the last step of ergosterol biosynthesis by converting ergosta-5,7,22,24(28)-tetraen-3beta-ol into ergosterol (PubMed:22947191). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaf…
messages: Endoplasmic reticulum membrane
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.

229533:FGSG 07280
gene id: 229533:FGSG_07280
uniprot id: I1RSZ3
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

229533:FGSG 03394
gene id: 229533:FGSG_03394
uniprot id: I1RHX8
names: Similarity
messages: Belongs to the Necrosis inducing protein (NPP1) family.

229533:FGSG 02078
gene id: 229533:FGSG_02078
uniprot id: I1REI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

229533:FGSG 06502
gene id: 229533:FGSG_06502
uniprot id: I1RR00
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

229533:FGSG 04103
gene id: 229533:FGSG_04103
uniprot id: I1RJS1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

229533:FGSG 01593
gene id: 229533:FGSG_01593
uniprot id: I1RDA1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11865
gene id: 229533:FGSG_11865
uniprot id: A0A1I9EX64
uniprot id: Q4IPA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

229533:FGSG 01152
gene id: 229533:FGSG_01152
uniprot id: I1RC49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

229533:FGSG 01328
gene id: 229533:FGSG_01328
uniprot id: I1RCK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

229533:FGSG 07146
gene id: 229533:FGSG_07146
uniprot id: I1RSM2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

229533:FGSG 07716
gene id: 229533:FGSG_07716
uniprot id: I1RU37
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01154
gene id: 229533:FGSG_01154
uniprot id: I1RC51
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

229533:FGSG 10612
gene id: 229533:FGSG_10612
uniprot id: I1S1K5
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 01225
gene id: 229533:FGSG_01225
uniprot id: V6QX21
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236).
messages: Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation (By similarity). The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Vacuole membrane

229533:FGSG 07857
gene id: 229533:FGSG_07857
uniprot id: I1RUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus

229533:FGSG 05593
gene id: 229533:FGSG_05593
uniprot id: I1RNL0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFA/CMAS family.
messages: Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. However, C-9 methylation of GlcCers is not essential for the sensitivity of F.graminearum to plant defensins MsDef1 and RsAFP2.
messages: Membrane
messages: Produces 65 to 75% nonmethylated and 25 to 35% methylated GlcCers. Exhibits severe growth defects and produces abnormal conidia. Also exhibits drastically reduced disease symptoms in wheat and much-delayed disease symptoms in Arabidopsis thaliana. A double-knockout with its paralog MT1 is not viable.

229533:FGSG 07380
gene id: 229533:FGSG_07380
uniprot id: I1RT81
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 09991
gene id: 229533:FGSG_09991
uniprot id: I1RZY1
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

229533:FGSG 05465
gene id: 229533:FGSG_05465
uniprot id: I1RN99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

229533:FGSG 12154
gene id: 229533:FGSG_12154
uniprot id: I1S5N3
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 03694
gene id: 229533:FGSG_03694
uniprot id: I1RIQ2
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

229533:FGSG 08264
gene id: 229533:FGSG_08264
uniprot id: I1RVI6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01653
gene id: 229533:FGSG_01653
uniprot id: I1RDF7
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.

229533:FGSG 10846
gene id: 229533:FGSG_10846
uniprot id: I1S262
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

229533:FGSG 09815
gene id: 229533:FGSG_09815
uniprot id: I1RZH4
names: Similarity
messages: Belongs to the PPP phosphatase family.

229533:FGSG 09891
gene id: 229533:FGSG_09891
uniprot id: I1RZP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.

229533:FGSG 09017
gene id: 229533:FGSG_09017
uniprot id: I1RXF1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10345
gene id: 229533:FGSG_10345
uniprot id: I1S0V5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

229533:FGSG 04130
gene id: 229533:FGSG_04130
uniprot id: I1RJU8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

229533:FGSG 06710
gene id: 229533:FGSG_06710
uniprot id: I1RRI7
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

229533:FGSG 00082
gene id: 229533:FGSG_00082
uniprot id: I1R9E6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 03541
gene id: 229533:FGSG_03541
uniprot id: I1RIB0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03497
gene id: 229533:FGSG_03497
uniprot id: I1RI71
names: Function
names: Similarity
messages: Belongs to the peptidase S1C family.
messages: Nuclear serine protease which mediates apoptosis.

229533:FGSG 05600
gene id: 229533:FGSG_05600
uniprot id: I1RNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 06721
gene id: 229533:FGSG_06721
uniprot id: I1RRJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
messages: telomere

229533:FGSG 03049
gene id: 229533:FGSG_03049
uniprot id: I1RH13
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 11594
gene id: 229533:FGSG_11594
uniprot id: V6R223
names: Similarity
messages: Belongs to the TRL1 family.

229533:FGSG 00572
gene id: 229533:FGSG_00572
uniprot id: I1RAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00666
gene id: 229533:FGSG_00666
uniprot id: I1RAX2
names: Similarity
messages: Belongs to the peroxin-13 family.

229533:FGSG 11626
gene id: 229533:FGSG_11626
uniprot id: A0A1I9FPH7
uniprot id: Q4HTT2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-8; H2BK6su = sumoylated Lys-8; H2BK7ac = acetylated Lys-9; H2BK7su = sumoylated Lys-9; H2BS10ph = phosphorylated Ser-12; H2BK11ac = acetylated Lys-13; H2BK16ac = acetylated Lys-24; H2BK16su = sumoylated Lys-24; H2BK17su = sumoylated Lys-25; H2BK123ub1 = monoubiquitinated Lys-131.

229533:FGSG 02328
gene id: 229533:FGSG_02328
uniprot id: I1RF62
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).
messages: Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:15811992, PubMed:16879655).
messages: Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).
messages: Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: Secreted
messages: extracellular space

229533:FGSG 06903
gene id: 229533:FGSG_06903
uniprot id: I1RRZ9
names: Similarity
messages: Belongs to the HEATR5 family.

229533:FGSG 03647
gene id: 229533:FGSG_03647
uniprot id: I1RIL0
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 02192
gene id: 229533:FGSG_02192
uniprot id: I1REU1
names: Similarity
messages: Belongs to the Luc7 family.

229533:FGSG 04185
gene id: 229533:FGSG_04185
uniprot id: I1RK01
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

229533:FGSG 09907
gene id: 229533:FGSG_09907
uniprot id: I1RZQ5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03366
gene id: 229533:FGSG_03366
uniprot id: I1RHV1
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

229533:FGSG 09647
gene id: 229533:FGSG_09647
uniprot id: I1RZ29
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 02496
gene id: 229533:FGSG_02496
uniprot id: I1RFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 05981
gene id: 229533:FGSG_05981
uniprot id: I1RPK8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08873
gene id: 229533:FGSG_08873
uniprot id: I1RX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

229533:FGSG 00669
gene id: 229533:FGSG_00669
uniprot id: I1RAX5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07409
gene id: 229533:FGSG_07409
uniprot id: Q4I5U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Nucleus
messages: Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).

229533:FGSG 07088
gene id: 229533:FGSG_07088
uniprot id: I1RSH0
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

229533:FGSG 07587
gene id: 229533:FGSG_07587
uniprot id: I1RTS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 04887
gene id: 229533:FGSG_04887
uniprot id: A0A1I9FRH9
uniprot id: Q4ID21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.
messages: Nucleus
messages: telomere

229533:FGSG 00541
gene id: 229533:FGSG_00541
uniprot id: I1RAL0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08693
gene id: 229533:FGSG_08693
uniprot id: I1RWL8
names: Similarity
messages: Belongs to the LipB family.

229533:FGSG 13483
gene id: 229533:FGSG_13483
uniprot id: I1S9F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 06061
gene id: 229533:FGSG_06061
uniprot id: I1RPT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

229533:FGSG 07303
gene id: 229533:FGSG_07303
uniprot id: I1RT13
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 02694
gene id: 229533:FGSG_02694
uniprot id: I1RG45
names: Similarity
messages: Belongs to the germin family.

229533:FGSG 07582
gene id: 229533:FGSG_07582
uniprot id: V6RHD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00108
gene id: 229533:FGSG_00108
uniprot id: I1R9G8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02502
gene id: 229533:FGSG_02502
uniprot id: I1RFM2
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:24785759). ERG3A and ERG3BB catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG2…
messages: Endoplasmic reticulum membrane
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Leads to a severe decrease in ergosterol production and virulence when ERG3B is also deleted (PubMed:23442154). Results in increased production of deoxynivalenol (DON) (PubMed:24785759).
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

229533:FGSG 12409
gene id: 229533:FGSG_12409
uniprot id: I1S6D8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05668
gene id: 229533:FGSG_05668
uniprot id: V6RAN2
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

229533:FGSG 00069
gene id: 229533:FGSG_00069
uniprot id: I1R9D4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08783
gene id: 229533:FGSG_08783
uniprot id: I1RWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 02566
gene id: 229533:FGSG_02566
uniprot id: I1RFS8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG16 family.
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16 complex (By similarity). Several units of each may be present in this complex (By similarity). Interacts directly with ATG12 (By similarity).
messages: Preautophagosomal structure membrane
messages: Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) (By similarity). Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).

229533:FGSG 00717
gene id: 229533:FGSG_00717
uniprot id: A0A1I9EWC4
uniprot id: Q4IPZ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

229533:FGSG 06962
gene id: 229533:FGSG_06962
uniprot id: V6RGN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

229533:FGSG 08773
gene id: 229533:FGSG_08773
uniprot id: A0A1I9F9Y0
uniprot id: Q4I1Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

229533:FGSG 05336
gene id: 229533:FGSG_05336
uniprot id: A0A1I9FQK1
uniprot id: Q4IBS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 05399
gene id: 229533:FGSG_05399
uniprot id: I1RN37
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00628
gene id: 229533:FGSG_00628
uniprot id: I1RAU2
names: Similarity
messages: Belongs to the BLOC1S1 family.

229533:FGSG 06184
gene id: 229533:FGSG_06184
uniprot id: I1RQ48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

229533:FGSG 04127
gene id: 229533:FGSG_04127
uniprot id: I1RJU5
names: Similarity
messages: Belongs to the RICTOR family.

229533:FGSG 08879
gene id: 229533:FGSG_08879
uniprot id: A0A1I9FAD5
uniprot id: Q4I1M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

229533:FGSG 11468
gene id: 229533:FGSG_11468
uniprot id: I1S3S2
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 06702
gene id: 229533:FGSG_06702
uniprot id: V6RLM7
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

229533:FGSG 06226
gene id: 229533:FGSG_06226
uniprot id: I1RQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 03201
gene id: 229533:FGSG_03201
uniprot id: I1RHF1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02588
gene id: 229533:FGSG_02588
uniprot id: I1RFU8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

229533:FGSG 06846
gene id: 229533:FGSG_06846
uniprot id: I1RRV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Inhibits the enzyme activity of ATPase.
messages: Mitochondrion

229533:FGSG 00092
gene id: 229533:FGSG_00092
uniprot id: I1R9F4
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 03779
gene id: 229533:FGSG_03779
uniprot id: I1RIY2
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

229533:FGSG 03162
gene id: 229533:FGSG_03162
uniprot id: I1RHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

229533:FGSG 06011
gene id: 229533:FGSG_06011
uniprot id: Q4I9U7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

229533:FGSG 05487
gene id: 229533:FGSG_05487
uniprot id: I1RNB7
names: Subcellular Location Annotation
messages: nuclear pore complex

229533:FGSG 05725
gene id: 229533:FGSG_05725
uniprot id: I1RNY0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04197
gene id: 229533:FGSG_04197
uniprot id: I1RK10
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 08459
gene id: 229533:FGSG_08459
uniprot id: I1RW07
names: Similarity
messages: Belongs to the methyltransferase superfamily.

229533:FGSG 07000
gene id: 229533:FGSG_07000
uniprot id: I1RS87
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 02724
gene id: 229533:FGSG_02724
uniprot id: A0A1I9F341
uniprot id: Q4IJ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Cytoplasm
messages: Nucleus
messages: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).

229533:FGSG 03292
gene id: 229533:FGSG_03292
uniprot id: I1RHN1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11938
gene id: 229533:FGSG_11938
uniprot id: I1S520
names: Similarity
messages: Belongs to the ATP phosphoribosyltransferase family.

229533:FGSG 00220
gene id: 229533:FGSG_00220
uniprot id: I1R9R5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03824
gene id: 229533:FGSG_03824
uniprot id: I1RJ25
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 01408
gene id: 229533:FGSG_01408
uniprot id: A0A1I9EYP9
uniprot id: Q4IN00
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
messages: Endoplasmic reticulum
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 00429
gene id: 229533:FGSG_00429
uniprot id: I1RAA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

229533:FGSG 05625
gene id: 229533:FGSG_05625
uniprot id: I1RNP1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

229533:FGSG 04187
gene id: 229533:FGSG_04187
uniprot id: I1RK03
names: Similarity
messages: Belongs to the pantothenate synthetase family.

229533:FGSG 05378
gene id: 229533:FGSG_05378
uniprot id: I1RN18
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

229533:FGSG 10049
gene id: 229533:FGSG_10049
uniprot id: I1S035
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

229533:FGSG 05888
gene id: 229533:FGSG_05888
uniprot id: I1RPC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

229533:FGSG 00269
gene id: 229533:FGSG_00269
uniprot id: V6QT89
names: Similarity
messages: Belongs to the NAPRTase family.

229533:FGSG 11202
gene id: 229533:FGSG_11202
uniprot id: I1S338
names: Similarity
messages: Belongs to the guanylate kinase family.

229533:FGSG 04426
gene id: 229533:FGSG_04426
uniprot id: I1RKL5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05727
gene id: 229533:FGSG_05727
uniprot id: I1RNY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

229533:FGSG 03901
gene id: 229533:FGSG_03901
uniprot id: I1RJ93
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

229533:FGSG 11484
gene id: 229533:FGSG_11484
uniprot id: I1S3T6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 07054
gene id: 229533:FGSG_07054
uniprot id: I1RSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

229533:FGSG 11042
gene id: 229533:FGSG_11042
uniprot id: I1S2P2
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 05488
gene id: 229533:FGSG_05488
uniprot id: I1RNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

229533:FGSG 02593
gene id: 229533:FGSG_02593
uniprot id: I1RFV2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

229533:FGSG 03160
gene id: 229533:FGSG_03160
uniprot id: I1RHB4
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 06868
gene id: 229533:FGSG_06868
uniprot id: I1RRW8
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

229533:FGSG 00420
gene id: 229533:FGSG_00420
uniprot id: Q4IQT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

229533:FGSG 10004
gene id: 229533:FGSG_10004
uniprot id: I1RZZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

229533:FGSG 06154
gene id: 229533:FGSG_06154
uniprot id: I1RQ21
names: Similarity
messages: Belongs to the heat shock protein 70 family.

229533:FGSG 05154
gene id: 229533:FGSG_05154
uniprot id: I1RMG4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

229533:FGSG 04260
gene id: 229533:FGSG_04260
uniprot id: V6R2Z5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07671
gene id: 229533:FGSG_07671
uniprot id: I1RU01
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 10986
gene id: 229533:FGSG_10986
uniprot id: I1S2J1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 09177
gene id: 229533:FGSG_09177
uniprot id: I1RXV1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00494
gene id: 229533:FGSG_00494
uniprot id: I1RAG6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00292
gene id: 229533:FGSG_00292
uniprot id: I1R9X7
names: Similarity
messages: Belongs to the NOC2 family.

229533:FGSG 05520
gene id: 229533:FGSG_05520
uniprot id: V6RAN7
names: Similarity
messages: Belongs to the cullin family.

229533:FGSG 10076
gene id: 229533:FGSG_10076
uniprot id: I1S060
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

229533:FGSG 00767
gene id: 229533:FGSG_00767
uniprot id: I1RB60
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 01982
gene id: 229533:FGSG_01982
uniprot id: I1REA0
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 04182
gene id: 229533:FGSG_04182
uniprot id: I1RJZ8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11720
gene id: 229533:FGSG_11720
uniprot id: I1S4F3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07734
gene id: 229533:FGSG_07734
uniprot id: I1RU52
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01337
gene id: 229533:FGSG_01337
uniprot id: V6QXG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

229533:FGSG 06215
gene id: 229533:FGSG_06215
uniprot id: I1RQ76
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Endoplasmic reticulum membrane
messages: Expression is significantly lower when CYP51A or CYP51C are deleted.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Lipid droplet
messages: Microsome membrane
messages: Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C…

229533:FGSG 04242
gene id: 229533:FGSG_04242
uniprot id: I1RK54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

229533:FGSG 00511
gene id: 229533:FGSG_00511
uniprot id: I1RAI1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00997
gene id: 229533:FGSG_00997
uniprot id: I1RBR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

229533:FGSG 01722
gene id: 229533:FGSG_01722
uniprot id: I1RDL3
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 06093
gene id: 229533:FGSG_06093
uniprot id: I1RPW1
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

229533:FGSG 02797
gene id: 229533:FGSG_02797
uniprot id: A0A1I9FAQ5
uniprot id: Q4IJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).

229533:FGSG 09074
gene id: 229533:FGSG_09074
uniprot id: I1RXK3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 05282
gene id: 229533:FGSG_05282
uniprot id: V6RB81
names: Similarity
messages: Belongs to the Rho GDI family.

229533:FGSG 10526
gene id: 229533:FGSG_10526
uniprot id: I1S1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFP11/STIP family.
messages: Nucleus

229533:FGSG 01135
gene id: 229533:FGSG_01135
uniprot id: I1RC33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

229533:FGSG 07665
gene id: 229533:FGSG_07665
uniprot id: I1RTZ5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05117
gene id: 229533:FGSG_05117
uniprot id: I1RMC8
names: Similarity
messages: Belongs to the CCDC124 family.

229533:FGSG 04862
gene id: 229533:FGSG_04862
uniprot id: I1RLP8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10419
gene id: 229533:FGSG_10419
uniprot id: A0A1I9F5J2
uniprot id: Q4HX89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).
messages: Membrane
messages: Vacuole membrane

229533:FGSG 03466
gene id: 229533:FGSG_03466
uniprot id: I1RI43
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

229533:FGSG 06123
gene id: 229533:FGSG_06123
uniprot id: I1RPZ1
names: Similarity
messages: Belongs to the polyprenol kinase family.

229533:FGSG 05775
gene id: 229533:FGSG_05775
uniprot id: I1RP25
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13426
gene id: 229533:FGSG_13426
uniprot id: I1S996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

229533:FGSG 10825
gene id: 229533:FGSG_10825
uniprot id: I1S241
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

229533:FGSG 11149
gene id: 229533:FGSG_11149
uniprot id: I1S2Z0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 08645
gene id: 229533:FGSG_08645
uniprot id: I1RWH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

229533:FGSG 01116
gene id: 229533:FGSG_01116
uniprot id: I1RC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

229533:FGSG 07596
gene id: 229533:FGSG_07596
uniprot id: I1RTT0
names: Similarity
messages: In the N-terminal section; belongs to the cytochrome P450 family.

229533:FGSG 11057
gene id: 229533:FGSG_11057
uniprot id: I1S2Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00741
gene id: 229533:FGSG_00741
uniprot id: I1RB36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

229533:FGSG 05720
gene id: 229533:FGSG_05720
uniprot id: I1RNX5
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 00700
gene id: 229533:FGSG_00700
uniprot id: A0A1I9EWA6
uniprot id: Q4IQ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

229533:FGSG 12597
gene id: 229533:FGSG_12597
uniprot id: I1S6X4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00375
gene id: 229533:FGSG_00375
uniprot id: I1RA51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

229533:FGSG 04044
gene id: 229533:FGSG_04044
uniprot id: I1RJL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

229533:FGSG 02208
gene id: 229533:FGSG_02208
uniprot id: I1REV4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03244
gene id: 229533:FGSG_03244
uniprot id: V6R5T7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

229533:FGSG 09756
gene id: 229533:FGSG_09756
uniprot id: I1RZC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

229533:FGSG 10818
gene id: 229533:FGSG_10818
uniprot id: I1S234
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 11160
gene id: 229533:FGSG_11160
uniprot id: I1S300
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 03475
gene id: 229533:FGSG_03475
uniprot id: I1RI50
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 07640
gene id: 229533:FGSG_07640
uniprot id: I1RTX2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 01343
gene id: 229533:FGSG_01343
uniprot id: I1RCM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 10234
gene id: 229533:FGSG_10234
uniprot id: I1S0K5
names: Similarity
messages: Belongs to the CCZ1 family.

229533:FGSG 00235
gene id: 229533:FGSG_00235
uniprot id: I1R9S7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09267
gene id: 229533:FGSG_09267
uniprot id: I1RY36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02908
gene id: 229533:FGSG_02908
uniprot id: I1RGN6
names: Function
names: Similarity
messages: Belongs to the choline monooxygenase family.
messages: Catalyzes the first step of the osmoprotectant glycine betaine synthesis.

229533:FGSG 04578
gene id: 229533:FGSG_04578
uniprot id: I1RL04
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

229533:FGSG 05789
gene id: 229533:FGSG_05789
uniprot id: I1RP37
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06573
gene id: 229533:FGSG_06573
uniprot id: I1RR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 22 family.
messages: Nucleus

229533:FGSG 07961
gene id: 229533:FGSG_07961
uniprot id: I1RUQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

229533:FGSG 11475
gene id: 229533:FGSG_11475
uniprot id: I1S3S9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09284
gene id: 229533:FGSG_09284
uniprot id: I1RY49
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

229533:FGSG 05983
gene id: 229533:FGSG_05983
uniprot id: I1RPL0
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 01294
gene id: 229533:FGSG_01294
uniprot id: I1RCH9
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 00730
gene id: 229533:FGSG_00730
uniprot id: A0A1I9EWE1
uniprot id: Q4IPX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09158
gene id: 229533:FGSG_09158
uniprot id: I1RXT3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02083
gene id: 229533:FGSG_02083
uniprot id: I1REJ4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09731
gene id: 229533:FGSG_09731
uniprot id: I1RZA1
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

229533:FGSG 10255
gene id: 229533:FGSG_10255
uniprot id: I1S0M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 11672
gene id: 229533:FGSG_11672
uniprot id: I1S4A5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01102
gene id: 229533:FGSG_01102
uniprot id: I1RC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

229533:FGSG 10137
gene id: 229533:FGSG_10137
uniprot id: I1S0B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

229533:FGSG 10069
gene id: 229533:FGSG_10069
uniprot id: I1S053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Nucleus

229533:FGSG 03243
gene id: 229533:FGSG_03243
uniprot id: I1RHI8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 08468
gene id: 229533:FGSG_08468
uniprot id: I1RW16
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 04899
gene id: 229533:FGSG_04899
uniprot id: I1RLT0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06427
gene id: 229533:FGSG_06427
uniprot id: I1RQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

229533:FGSG 09109
gene id: 229533:FGSG_09109
uniprot id: I1RXN5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 08926
gene id: 229533:FGSG_08926
uniprot id: I1RX76
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

229533:FGSG 06865
gene id: 229533:FGSG_06865
uniprot id: V6RM66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.
messages: Mitochondrion matrix

229533:FGSG 03860
gene id: 229533:FGSG_03860
uniprot id: I1RJ57
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 10251
gene id: 229533:FGSG_10251
uniprot id: I1S0L8
names: Similarity
messages: Belongs to the WD repeat LST8 family.

229533:FGSG 03914
gene id: 229533:FGSG_03914
uniprot id: I1RJA5
names: Similarity
messages: Belongs to the isochorismatase family.

229533:FGSG 02513
gene id: 229533:FGSG_02513
uniprot id: I1RFN3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06718
gene id: 229533:FGSG_06718
uniprot id: I1RRJ3
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

229533:FGSG 09834
gene id: 229533:FGSG_09834
uniprot id: V6RPS5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

229533:FGSG 11523
gene id: 229533:FGSG_11523
uniprot id: I1S3X3
names: Similarity
messages: Belongs to the ustYa family.

229533:FGSG 10522
gene id: 229533:FGSG_10522
uniprot id: I1S1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 10379
gene id: 229533:FGSG_10379
uniprot id: I1S0Y7
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

229533:FGSG 05747
gene id: 229533:FGSG_05747
uniprot id: I1RP00
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01361
gene id: 229533:FGSG_01361
uniprot id: I1RCN8
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

229533:FGSG 07265
gene id: 229533:FGSG_07265
uniprot id: I1RSX8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07413
gene id: 229533:FGSG_07413
uniprot id: I1RTB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 00465
gene id: 229533:FGSG_00465
uniprot id: I1RAD8
names: Similarity
messages: Belongs to the IUNH family.

229533:FGSG 05955
gene id: 229533:FGSG_05955
uniprot id: A0A1I9FV31
uniprot id: I1RPI4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide (Probable). Glucosylceramides play important roles in growth, differentiation and pathogenicity. Contribution to fungal pathogenesis is host-dependent (PubMed:17908205).
messages: Golgi apparatus membrane
messages: Results in complete loss of glucosylceramides (GluCers) in mutant cells. Shows a significant change in the conidial morphology and displays a dramatic polar growth defect, and its mycelia are resistant to cell wall degrading enzymes. Shows increased resistance to plant defensins MsDef1 and RsAFP2, but not MsDef4.
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

229533:FGSG 09498
gene id: 229533:FGSG_09498
uniprot id: I1RYP0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10831
gene id: 229533:FGSG_10831
uniprot id: I1S247
names: Similarity
messages: Belongs to the p23/wos2 family.

229533:FGSG 00349
gene id: 229533:FGSG_00349
uniprot id: A0A1I9EV33
uniprot id: Q4IR09
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 08702
gene id: 229533:FGSG_08702
uniprot id: I1RWM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

229533:FGSG 05375
gene id: 229533:FGSG_05375
uniprot id: V6R9L8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 09229
gene id: 229533:FGSG_09229
uniprot id: A0A1I9FI97
uniprot id: Q4I0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.

229533:FGSG 10005
gene id: 229533:FGSG_10005
uniprot id: V6RXE7
names: Similarity
messages: Belongs to the cytidylyltransferase family.

229533:FGSG 11054
gene id: 229533:FGSG_11054
uniprot id: I1S2Q4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

229533:FGSG 10695
gene id: 229533:FGSG_10695
uniprot id: I1S1S9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 06937
gene id: 229533:FGSG_06937
uniprot id: I1RS30
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

229533:FGSG 13746
gene id: 229533:FGSG_13746
uniprot id: I1SA65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 05777
gene id: 229533:FGSG_05777
uniprot id: I1RP27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

229533:FGSG 01935
gene id: 229533:FGSG_01935
uniprot id: A0A1I9F0K9
uniprot id: Q4ILH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

229533:FGSG 02492
gene id: 229533:FGSG_02492
uniprot id: I1RFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
messages: nucleolus

229533:FGSG 05160
gene id: 229533:FGSG_05160
uniprot id: I1RMH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

229533:FGSG 01279
gene id: 229533:FGSG_01279
uniprot id: I1RCG5
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

229533:FGSG 05275
gene id: 229533:FGSG_05275
uniprot id: I1RMS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

229533:FGSG 10200
gene id: 229533:FGSG_10200
uniprot id: I1S0H2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

229533:FGSG 05382
gene id: 229533:FGSG_05382
uniprot id: I1RN21
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 06560
gene id: 229533:FGSG_06560
uniprot id: I1RR51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

229533:FGSG 11157
gene id: 229533:FGSG_11157
uniprot id: I1S2Z7
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 10791
gene id: 229533:FGSG_10791
uniprot id: A0A1I9FTE5
uniprot id: Q4HW67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: P-body
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 11671
gene id: 229533:FGSG_11671
uniprot id: I1S4A4
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 05220
gene id: 229533:FGSG_05220
uniprot id: I1RMM7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

229533:FGSG 00810
gene id: 229533:FGSG_00810
uniprot id: I1RBA0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 06159
gene id: 229533:FGSG_06159
uniprot id: I1RQ26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

229533:FGSG 09400
gene id: 229533:FGSG_09400
uniprot id: V6RNC7
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

229533:FGSG 08034
gene id: 229533:FGSG_08034
uniprot id: I1RUX5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02714
gene id: 229533:FGSG_02714
uniprot id: I1RG64
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

229533:FGSG 03202
gene id: 229533:FGSG_03202
uniprot id: I1RHF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 08598
gene id: 229533:FGSG_08598
uniprot id: I1RWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex.
messages: Nucleus

229533:FGSG 09757
gene id: 229533:FGSG_09757
uniprot id: I1RZC4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

229533:FGSG 06575
gene id: 229533:FGSG_06575
uniprot id: I1RR63
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07254
gene id: 229533:FGSG_07254
uniprot id: A0A1I9FN00
uniprot id: Q4I6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 01356
gene id: 229533:FGSG_01356
uniprot id: A0A1I9EYL7
uniprot id: Q4IN52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

229533:FGSG 03838
gene id: 229533:FGSG_03838
uniprot id: I1RJ39
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 10909
gene id: 229533:FGSG_10909
uniprot id: I1S2C1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

229533:FGSG 03952
gene id: 229533:FGSG_03952
uniprot id: I1RJD7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

229533:FGSG 10595
gene id: 229533:FGSG_10595
uniprot id: I1S1J0
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 13881
gene id: 229533:FGSG_13881
uniprot id: I1SAK0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 00365
gene id: 229533:FGSG_00365
uniprot id: V6QUE6
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

229533:FGSG 10994
gene id: 229533:FGSG_10994
uniprot id: I1S2J8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Nucleus
messages: Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.
messages: Transcription regulator; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). Positively regulates the expression the Fg3_54/C64 gene cluster (PubMed:30804501).

229533:FGSG 05621
gene id: 229533:FGSG_05621
uniprot id: I1RNN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Membrane
messages: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Vacuole membrane

229533:FGSG 05511
gene id: 229533:FGSG_05511
uniprot id: I1RND8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

229533:FGSG 11263
gene id: 229533:FGSG_11263
uniprot id: V6RW01
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 08498
gene id: 229533:FGSG_08498
uniprot id: I1RW43
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

229533:FGSG 05985
gene id: 229533:FGSG_05985
uniprot id: I1RPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

229533:FGSG 00502
gene id: 229533:FGSG_00502
uniprot id: I1RAH2
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

229533:FGSG 08079
gene id: 229533:FGSG_08079
uniprot id: I1RV19
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochrome P450 monooxygenase FG08079; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).
messages: Highly expressed under trichothecene-producing conditions.
messages: Membrane
messages: Results in the loss of butelonide production.

229533:FGSG 05065
gene id: 229533:FGSG_05065
uniprot id: I1RM82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

229533:FGSG 09303
gene id: 229533:FGSG_09303
uniprot id: I1RY66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 11113
gene id: 229533:FGSG_11113
uniprot id: I1S2V9
names: Cofactor
messages: Binds 2 manganese ions per subunit.

229533:FGSG 07121
gene id: 229533:FGSG_07121
uniprot id: I1RSK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

229533:FGSG 06495
gene id: 229533:FGSG_06495
uniprot id: I1RQZ3
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

229533:FGSG 05977
gene id: 229533:FGSG_05977
uniprot id: I1RPK4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 00186
gene id: 229533:FGSG_00186
uniprot id: I1R9N5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

229533:FGSG 10010
gene id: 229533:FGSG_10010
uniprot id: I1RZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

229533:FGSG 00337
gene id: 229533:FGSG_00337
uniprot id: I1RA20
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 00327
gene id: 229533:FGSG_00327
uniprot id: I1RA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

229533:FGSG 03968
gene id: 229533:FGSG_03968
uniprot id: I1RJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 03996
gene id: 229533:FGSG_03996
uniprot id: I1RJH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

229533:FGSG 08532
gene id: 229533:FGSG_08532
uniprot id: I1RW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

229533:FGSG 08415
gene id: 229533:FGSG_08415
uniprot id: I1RVW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

229533:FGSG 01362
gene id: 229533:FGSG_01362
uniprot id: I1RCN9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the velvet family. VelB subfamily.
messages: Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (By similarity). Forms a heterodimeric complex with vosA; the formation of the velB-vosA complex is light-dependent (By similarity).
messages: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Controls the expression of the pink pigment aurofusarin and the mycotoxin deoxynivalenol gene clusters (PubMed:22713714). Regulates hyphae formation, hyphal hydrophobicity and conidiation (PubMed:22713714). Regulates of cell wall integrity and pathogenicity (PubMed:22713714).
messages: Cytoplasm
messages: Exhibits reduced pink pigment formation, but increased yellow pigment production (PubMed:22713714). Down-regulates the six genes involved in biosynthesis of the pink pigment aurofusarin (PubMed:22713714). Down-regulates also the genes involved in the mycotoxin deoxynivalenol biosynthesis (PubMed:22713714). Suppresses of aerial hyphae formation, reduces hyphal hydrophobicity and highly increases conidiation (PubMed:22713714). Impaired virulence on flowering wheat head (PubMed:22713714).
messages: Nucleus

229533:FGSG 10077
gene id: 229533:FGSG_10077
uniprot id: I1S061
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

229533:FGSG 04087
gene id: 229533:FGSG_04087
uniprot id: I1RJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

229533:FGSG 03424
gene id: 229533:FGSG_03424
uniprot id: I1RI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03430
gene id: 229533:FGSG_03430
uniprot id: V6RD34
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 05157
gene id: 229533:FGSG_05157
uniprot id: I1RMG7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08819
gene id: 229533:FGSG_08819
uniprot id: A0A1I9F9P5
uniprot id: Q4I1T9
names: Similarity
messages: Belongs to the EFR3 family.

229533:FGSG 05973
gene id: 229533:FGSG_05973
uniprot id: I1RPK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

229533:FGSG 00694
gene id: 229533:FGSG_00694
uniprot id: I1RAZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 06338
gene id: 229533:FGSG_06338
uniprot id: Q4I8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.

229533:FGSG 01672
gene id: 229533:FGSG_01672
uniprot id: I1RDH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

229533:FGSG 10299
gene id: 229533:FGSG_10299
uniprot id: I1S0R2
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

229533:FGSG 05076
gene id: 229533:FGSG_05076
uniprot id: I1RM91
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07076
gene id: 229533:FGSG_07076
uniprot id: I1RSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

229533:FGSG 05924
gene id: 229533:FGSG_05924
uniprot id: I1RPF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

229533:FGSG 05958
gene id: 229533:FGSG_05958
uniprot id: I1RPI7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09871
gene id: 229533:FGSG_09871
uniprot id: I1RZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

229533:FGSG 10144
gene id: 229533:FGSG_10144
uniprot id: I1S0C2
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anamorsin family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

229533:FGSG 01226
gene id: 229533:FGSG_01226
uniprot id: A0A1I9EY30
uniprot id: Q4INI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Nucleus
messages: cytoskeleton

229533:FGSG 09432
gene id: 229533:FGSG_09432
uniprot id: I1RYH9
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

229533:FGSG 13834
gene id: 229533:FGSG_13834
uniprot id: I1SAF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 01452
gene id: 229533:FGSG_01452
uniprot id: I1RCW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

229533:FGSG 06269
gene id: 229533:FGSG_06269
uniprot id: I1RQC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 09853
gene id: 229533:FGSG_09853
uniprot id: I1RZK6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

229533:FGSG 09392
gene id: 229533:FGSG_09392
uniprot id: I1RYE5
names: Function
names: Similarity
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.

229533:FGSG 07199
gene id: 229533:FGSG_07199
uniprot id: I1RSR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

229533:FGSG 00305
gene id: 229533:FGSG_00305
uniprot id: I1R9Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

229533:FGSG 02990
gene id: 229533:FGSG_02990
uniprot id: I1RGW0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07851
gene id: 229533:FGSG_07851
uniprot id: V6RJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

229533:FGSG 08722
gene id: 229533:FGSG_08722
uniprot id: I1RWP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion

229533:FGSG 10394
gene id: 229533:FGSG_10394
uniprot id: V6RSW9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10587
gene id: 229533:FGSG_10587
uniprot id: I1S1I3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

229533:FGSG 09595
gene id: 229533:FGSG_09595
uniprot id: I1RYY2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03912
gene id: 229533:FGSG_03912
uniprot id: I1RJA3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09774
gene id: 229533:FGSG_09774
uniprot id: A0A1I9FS72
uniprot id: Q4HZ34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

229533:FGSG 03547
gene id: 229533:FGSG_03547
uniprot id: I1RIB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

229533:FGSG 09299
gene id: 229533:FGSG_09299
uniprot id: I1RY62
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

229533:FGSG 02016
gene id: 229533:FGSG_02016
uniprot id: I1REC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

229533:FGSG 05651
gene id: 229533:FGSG_05651
uniprot id: I1RNR5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

229533:FGSG 09865
gene id: 229533:FGSG_09865
uniprot id: I1RZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 04166
gene id: 229533:FGSG_04166
uniprot id: I1RJY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

229533:FGSG 09668
gene id: 229533:FGSG_09668
uniprot id: A0A1I9FI29
uniprot id: Q4HZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 04157
gene id: 229533:FGSG_04157
uniprot id: I1RJX3
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 06000
gene id: 229533:FGSG_06000
uniprot id: I1RPM5
names: Similarity
messages: Belongs to the TTC36 family.

229533:FGSG 09899
gene id: 229533:FGSG_09899
uniprot id: I1RZP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

229533:FGSG 10859
gene id: 229533:FGSG_10859
uniprot id: I1S273
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

229533:FGSG 08902
gene id: 229533:FGSG_08902
uniprot id: I1RX52
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

229533:FGSG 07509
gene id: 229533:FGSG_07509
uniprot id: I1RTK0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06699
gene id: 229533:FGSG_06699
uniprot id: I1RRH8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06468
gene id: 229533:FGSG_06468
uniprot id: I1RQW7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08626
gene id: 229533:FGSG_08626
uniprot id: V6RJG0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00719
gene id: 229533:FGSG_00719
uniprot id: I1RB16
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10434
gene id: 229533:FGSG_10434
uniprot id: I1S139
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 00446
gene id: 229533:FGSG_00446
uniprot id: I1RAB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

229533:FGSG 05739
gene id: 229533:FGSG_05739
uniprot id: I1RNZ2
names: Similarity
messages: Belongs to the Cyclase 1 superfamily.

229533:FGSG 07874
gene id: 229533:FGSG_07874
uniprot id: I1RUI1
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 02594
gene id: 229533:FGSG_02594
uniprot id: I1RFV3
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

229533:FGSG 00416
gene id: 229533:FGSG_00416
uniprot id: I1RA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 01091
gene id: 229533:FGSG_01091
uniprot id: I1RBZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

229533:FGSG 13357
gene id: 229533:FGSG_13357
uniprot id: I1S927
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 00574
gene id: 229533:FGSG_00574
uniprot id: I1RAP2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 12692
gene id: 229533:FGSG_12692
uniprot id: I1S769
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 06845
gene id: 229533:FGSG_06845
uniprot id: V6REZ4
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

229533:FGSG 02793
gene id: 229533:FGSG_02793
uniprot id: I1RGD4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG23 family.
messages: Cytoplasm
messages: Forms a complex with ATG9 and ATG27 (By similarity).
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy (By similarity). Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236).

229533:FGSG 11048
gene id: 229533:FGSG_11048
uniprot id: I1S2P8
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

229533:FGSG 08402
gene id: 229533:FGSG_08402
uniprot id: I1RVV7
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

229533:FGSG 01936
gene id: 229533:FGSG_01936
uniprot id: I1RE61
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10253
gene id: 229533:FGSG_10253
uniprot id: I1S0M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

229533:FGSG 01054
gene id: 229533:FGSG_01054
uniprot id: I1RBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

229533:FGSG 01389
gene id: 229533:FGSG_01389
uniprot id: I1RCR3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 11367
gene id: 229533:FGSG_11367
uniprot id: I1S3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 07144
gene id: 229533:FGSG_07144
uniprot id: I1RSM1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00325
gene id: 229533:FGSG_00325
uniprot id: I1RA08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 05029
gene id: 229533:FGSG_05029
uniprot id: A0A1I9FSH1
uniprot id: Q4ICM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex, at least composed of mtHsp70 (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18.
messages: Component of the PAM complex.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02343
gene id: 229533:FGSG_02343
uniprot id: I1RF77
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11340
gene id: 229533:FGSG_11340
uniprot id: I1S3F9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02741
gene id: 229533:FGSG_02741
uniprot id: I1RG85
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10896
gene id: 229533:FGSG_10896
uniprot id: A0A1I9FQL8
uniprot id: Q4HVW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Component of pre-60S ribosomal complexes.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 10313
gene id: 229533:FGSG_10313
uniprot id: I1S0S6
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

229533:FGSG 01926
gene id: 229533:FGSG_01926
uniprot id: I1RE52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

229533:FGSG 08864
gene id: 229533:FGSG_08864
uniprot id: I1RX21
names: Function
messages: Required for the assembly of cytochrome c oxidase.

229533:FGSG 12599
gene id: 229533:FGSG_12599
uniprot id: I1S6X6
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 02371
gene id: 229533:FGSG_02371
uniprot id: I1RFA2
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08282
gene id: 229533:FGSG_08282
uniprot id: I1RVK2
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 03288
gene id: 229533:FGSG_03288
uniprot id: I1RHM8
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

229533:FGSG 05538
gene id: 229533:FGSG_05538
uniprot id: Q4IB70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
messages: Nucleus

229533:FGSG 06925
gene id: 229533:FGSG_06925
uniprot id: I1RS19
names: Similarity
messages: Belongs to the THADA family.

229533:FGSG 01870
gene id: 229533:FGSG_01870
uniprot id: I1RE00
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

229533:FGSG 01638
gene id: 229533:FGSG_01638
uniprot id: I1RDE2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01923
gene id: 229533:FGSG_01923
uniprot id: I1RE49
names: Similarity
messages: Belongs to the CAP family.

229533:FGSG 12341
gene id: 229533:FGSG_12341
uniprot id: I1S670
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04326
gene id: 229533:FGSG_04326
uniprot id: I1RKC6
names: Similarity
messages: Belongs to the BRX1 family.

229533:FGSG 04722
gene id: 229533:FGSG_04722
uniprot id: I1RLC9
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 05283
gene id: 229533:FGSG_05283
uniprot id: I1RMT5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04547
gene id: 229533:FGSG_04547
uniprot id: I1RKX6
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 13456
gene id: 229533:FGSG_13456
uniprot id: I1S9C6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 05542
gene id: 229533:FGSG_05542
uniprot id: I1RNG5
names: Subcellular Location Annotation
messages: nuclear pore complex

229533:FGSG 01016
gene id: 229533:FGSG_01016
uniprot id: I1RBS6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

229533:FGSG 08135
gene id: 229533:FGSG_08135
uniprot id: I1RV71
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01495
gene id: 229533:FGSG_01495
uniprot id: I1RD08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 04892
gene id: 229533:FGSG_04892
uniprot id: I1RLS4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 12602
gene id: 229533:FGSG_12602
uniprot id: I1S6X9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05605
gene id: 229533:FGSG_05605
uniprot id: I1RNM2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.

229533:FGSG 11008
gene id: 229533:FGSG_11008
uniprot id: I1S2L1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 06530
gene id: 229533:FGSG_06530
uniprot id: I1RR24
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

229533:FGSG 08528
gene id: 229533:FGSG_08528
uniprot id: V6RS91
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.

229533:FGSG 07846
gene id: 229533:FGSG_07846
uniprot id: I1RUF5
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 07442
gene id: 229533:FGSG_07442
uniprot id: I1RTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

229533:FGSG 13971
gene id: 229533:FGSG_13971
uniprot id: I1SAU0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00306
gene id: 229533:FGSG_00306
uniprot id: I1R9Y9
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

229533:FGSG 05599
gene id: 229533:FGSG_05599
uniprot id: I1RNL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

229533:FGSG 05912
gene id: 229533:FGSG_05912
uniprot id: I1RPE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Homodimer.
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG12 converts mevalonate into 5-phosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
messages: cytosol

229533:FGSG 08560
gene id: 229533:FGSG_08560
uniprot id: A0A1I9F8I2
uniprot id: Q4I2J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

229533:FGSG 01324
gene id: 229533:FGSG_01324
uniprot id: I1RCK5
names: Similarity
messages: Belongs to the VPS37 family.

229533:FGSG 00986
gene id: 229533:FGSG_00986
uniprot id: I1RBQ2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

229533:FGSG 03136
gene id: 229533:FGSG_03136
uniprot id: I1RH91
names: Similarity
messages: Belongs to the TPP enzyme family.

229533:FGSG 08841
gene id: 229533:FGSG_08841
uniprot id: I1RX00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

229533:FGSG 07358
gene id: 229533:FGSG_07358
uniprot id: I1RT61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Membrane
messages: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Vacuole membrane

229533:FGSG 11493
gene id: 229533:FGSG_11493
uniprot id: I1S3U5
names: Similarity
messages: Belongs to the Necrosis inducing protein (NPP1) family.

229533:FGSG 01032
gene id: 229533:FGSG_01032
uniprot id: I1RBU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 04324
gene id: 229533:FGSG_04324
uniprot id: I1RKC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

229533:FGSG 09673
gene id: 229533:FGSG_09673
uniprot id: I1RZ48
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04543
gene id: 229533:FGSG_04543
uniprot id: I1RKX2
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

229533:FGSG 08169
gene id: 229533:FGSG_08169
uniprot id: I1RVA3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02094
gene id: 229533:FGSG_02094
uniprot id: V6QZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 04028
gene id: 229533:FGSG_04028
uniprot id: A0A1I9FF33
uniprot id: Q4IFI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Interacts with the SSU processome.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 10723
gene id: 229533:FGSG_10723
uniprot id: I1S1V1
names: Similarity
messages: Belongs to the Mo25 family.

229533:FGSG 00398
gene id: 229533:FGSG_00398
uniprot id: Q4IQW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

229533:FGSG 07428
gene id: 229533:FGSG_07428
uniprot id: V6RGY0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

229533:FGSG 11092
gene id: 229533:FGSG_11092
uniprot id: I1S2T9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10908
gene id: 229533:FGSG_10908
uniprot id: I1S2C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules.
messages: nucleolus

229533:FGSG 08852
gene id: 229533:FGSG_08852
uniprot id: Q4I1Q6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

229533:FGSG 09740
gene id: 229533:FGSG_09740
uniprot id: A0A1I9FI99
uniprot id: Q4HZ68
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 00631
gene id: 229533:FGSG_00631
uniprot id: I1RAU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

229533:FGSG 05999
gene id: 229533:FGSG_05999
uniprot id: I1RPM4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

229533:FGSG 09564
gene id: 229533:FGSG_09564
uniprot id: I1RYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.
messages: Endosome membrane
messages: Membrane
messages: Vacuole membrane

229533:FGSG 08892
gene id: 229533:FGSG_08892
uniprot id: I1RX43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATALPHA1 family.
messages: Nucleus

229533:FGSG 10524
gene id: 229533:FGSG_10524
uniprot id: I1S1C4
names: Similarity
messages: Belongs to the SAPS family.

229533:FGSG 01161
gene id: 229533:FGSG_01161
uniprot id: I1RC58
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

229533:FGSG 08578
gene id: 229533:FGSG_08578
uniprot id: I1RWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

229533:FGSG 00481
gene id: 229533:FGSG_00481
uniprot id: I1RAF4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08884
gene id: 229533:FGSG_08884
uniprot id: I1RX35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

229533:FGSG 06056
gene id: 229533:FGSG_06056
uniprot id: I1RPS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 02634
gene id: 229533:FGSG_02634
uniprot id: I1RFY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 10512
gene id: 229533:FGSG_10512
uniprot id: I1S1B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

229533:FGSG 06624
gene id: 229533:FGSG_06624
uniprot id: I1RRA7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 08372
gene id: 229533:FGSG_08372
uniprot id: I1RVS9
names: Similarity
messages: Belongs to the XPC family.

229533:FGSG 08940
gene id: 229533:FGSG_08940
uniprot id: I1RX87
names: Similarity
messages: Belongs to the syntaxin family.

229533:FGSG 11536
gene id: 229533:FGSG_11536
uniprot id: I1S3Y5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 04179
gene id: 229533:FGSG_04179
uniprot id: I1RJZ5
names: Function
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.

229533:FGSG 10461
gene id: 229533:FGSG_10461
uniprot id: I1S163
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Abolishes the production of fusarielins F, G and H, but accumulates the intermediate prefusarielin.
messages: Belongs to the cytochrome P450 family.
messages: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606).
messages: Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes.
messages: Membrane

229533:FGSG 06947
gene id: 229533:FGSG_06947
uniprot id: I1RS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane

229533:FGSG 07315
gene id: 229533:FGSG_07315
uniprot id: I1RT23
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to he…
messages: Endoplasmic reticulum membrane
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Surprisingly, does not show changed sensitivity to amines and does not lead to depletion of ergosterol.

229533:FGSG 01712
gene id: 229533:FGSG_01712
uniprot id: V6QYL1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10352
gene id: 229533:FGSG_10352
uniprot id: A0A1I9F5I2
uniprot id: Q4HXF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

229533:FGSG 03384
gene id: 229533:FGSG_03384
uniprot id: I1RHW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 02807
gene id: 229533:FGSG_02807
uniprot id: I1RGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

229533:FGSG 00655
gene id: 229533:FGSG_00655
uniprot id: V6QU63
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 01486
gene id: 229533:FGSG_01486
uniprot id: I1RCZ9
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

229533:FGSG 00800
gene id: 229533:FGSG_00800
uniprot id: I1RB90
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04317
gene id: 229533:FGSG_04317
uniprot id: V6R3I7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01592
gene id: 229533:FGSG_01592
uniprot id: I1RDA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

229533:FGSG 03601
gene id: 229533:FGSG_03601
uniprot id: I1RIG9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 06542
gene id: 229533:FGSG_06542
uniprot id: Q4I8B6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase specific for casein kinase 1.
messages: The DHHC domain is required for palmitoyltransferase activity.

229533:FGSG 11254
gene id: 229533:FGSG_11254
uniprot id: I1S384
names: Function
names: Similarity
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.

229533:FGSG 09599
gene id: 229533:FGSG_09599
uniprot id: V6RW66
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 01944
gene id: 229533:FGSG_01944
uniprot id: I1RE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 05213
gene id: 229533:FGSG_05213
uniprot id: I1RMM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
messages: Membrane

229533:FGSG 00313
gene id: 229533:FGSG_00313
uniprot id: I1R9Z6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05327
gene id: 229533:FGSG_05327
uniprot id: I1RMX4
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

229533:FGSG 11480
gene id: 229533:FGSG_11480
uniprot id: I1S3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06739
gene id: 229533:FGSG_06739
uniprot id: I1RRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

229533:FGSG 11851
gene id: 229533:FGSG_11851
uniprot id: I1S4T3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Plays a pivotal role in conidiation by regulating cell cycle pathways and other conidiation-related genes (PubMed:24039821).
messages: Belongs to the TEC1 family.
messages: Expression is positively regulated by flbD (PubMed:25277408).
messages: Leads to abnormally shaped phialides and abolishes production of conidia (PubMed:24039821).
messages: Nucleus

229533:FGSG 03941
gene id: 229533:FGSG_03941
uniprot id: V6R5P0
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 03233
gene id: 229533:FGSG_03233
uniprot id: I1RHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 07154
gene id: 229533:FGSG_07154
uniprot id: I1RSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

229533:FGSG 01176
gene id: 229533:FGSG_01176
uniprot id: I1RC73
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with HOG1.
messages: Nucleus
messages: Phosphorylation at Thr-82, Ser-92, Ser-102, thr-117 and ser-305 by HOG1 is required for regulating expression of ergosterol biosynthesis genes.
messages: Reduces the production of ergosterol (PubMed:30874562). Leads to increased sensitivity to azole compounds, but not to iprodione and fludioxonil that target the high osmolarity glycerol (HOG) pathway (PubMed:30874562).
messages: Transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562). Positively regulates the expression of ergosterol biosynthesis genes including CYP51A and CYP51B encoding the sterol 14-alpha demethylase, and ERG6A and ERG6B encoding the sterol 24-C-methyltransferase (PubMed:30874562).

229533:FGSG 00802
gene id: 229533:FGSG_00802
uniprot id: I1RB92
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

229533:FGSG 13829
gene id: 229533:FGSG_13829
uniprot id: I1SAE8
names: Cofactor
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.

229533:FGSG 13064
gene id: 229533:FGSG_13064
uniprot id: I1S886
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

229533:FGSG 04810
gene id: 229533:FGSG_04810
uniprot id: I1RLK6
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

229533:FGSG 01540
gene id: 229533:FGSG_01540
uniprot id: I1RD51
names: Similarity
messages: Belongs to the PITHD1 family.

229533:FGSG 07628
gene id: 229533:FGSG_07628
uniprot id: I1RTW0
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 11643
gene id: 229533:FGSG_11643
uniprot id: I1S476
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

229533:FGSG 06596
gene id: 229533:FGSG_06596
uniprot id: I1RR82
names: Similarity
messages: Belongs to the catalase family.

229533:FGSG 02735
gene id: 229533:FGSG_02735
uniprot id: I1RG80
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 04454
gene id: 229533:FGSG_04454
uniprot id: I1RKP1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

229533:FGSG 02143
gene id: 229533:FGSG_02143
uniprot id: V6QYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

229533:FGSG 10718
gene id: 229533:FGSG_10718
uniprot id: I1S1U7
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 07245
gene id: 229533:FGSG_07245
uniprot id: I1RSW0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06689
gene id: 229533:FGSG_06689
uniprot id: I1RRG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 10113
gene id: 229533:FGSG_10113
uniprot id: I1S094
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

229533:FGSG 03375
gene id: 229533:FGSG_03375
uniprot id: I1RHV9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 13519
gene id: 229533:FGSG_13519
uniprot id: I1S9I8
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 05475
gene id: 229533:FGSG_05475
uniprot id: I1RNA7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06149
gene id: 229533:FGSG_06149
uniprot id: I1RQ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

229533:FGSG 02421
gene id: 229533:FGSG_02421
uniprot id: I1RFE7
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

229533:FGSG 02632
gene id: 229533:FGSG_02632
uniprot id: I1RFY7
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 07914
gene id: 229533:FGSG_07914
uniprot id: I1RUL5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00813
gene id: 229533:FGSG_00813
uniprot id: I1RBA2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 12839
gene id: 229533:FGSG_12839
uniprot id: I1S7L6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

229533:FGSG 07594
gene id: 229533:FGSG_07594
uniprot id: I1RTS8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 02974
gene id: 229533:FGSG_02974
uniprot id: I1RGU6
names: Caution
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 08469
gene id: 229533:FGSG_08469
uniprot id: I1RW17
names: Similarity
messages: Belongs to the IMPACT family.

229533:FGSG 03680
gene id: 229533:FGSG_03680
uniprot id: V6R6F0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA) (Probable). FgAQP3 has NPA/NPV motifs which is in accordance with the fungal aquaporins (NPx and NxA) (Probable).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Leads to no variable phenotypes.
messages: Membrane
messages: Probable water channel that may have redundant functions with FgAQP5.

229533:FGSG 10513
gene id: 229533:FGSG_10513
uniprot id: I1S1B3
names: Similarity
messages: Belongs to the CDIP1/LITAF family.

229533:FGSG 10315
gene id: 229533:FGSG_10315
uniprot id: I1S0S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

229533:FGSG 04642
gene id: 229533:FGSG_04642
uniprot id: I1RL59
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 03853
gene id: 229533:FGSG_03853
uniprot id: I1RJ50
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07008
gene id: 229533:FGSG_07008
uniprot id: I1RS94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

229533:FGSG 13497
gene id: 229533:FGSG_13497
uniprot id: I1S9G6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07892
gene id: 229533:FGSG_07892
uniprot id: I1RUJ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

229533:FGSG 13011
gene id: 229533:FGSG_13011
uniprot id: I1S835
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

229533:FGSG 00489
gene id: 229533:FGSG_00489
uniprot id: I1RAG2
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 01378
gene id: 229533:FGSG_01378
uniprot id: I1RCQ4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03614
gene id: 229533:FGSG_03614
uniprot id: I1RII1
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

229533:FGSG 02130
gene id: 229533:FGSG_02130
uniprot id: I1REN7
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

229533:FGSG 10693
gene id: 229533:FGSG_10693
uniprot id: I1S1S7
names: Similarity
messages: Belongs to the lysophospholipase family.

229533:FGSG 11081
gene id: 229533:FGSG_11081
uniprot id: I1S2S8
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 11471
gene id: 229533:FGSG_11471
uniprot id: I1S3S5
names: Similarity
messages: Belongs to the ustYa family.

229533:FGSG 08078
gene id: 229533:FGSG_08078
uniprot id: I1RV18
names: Function
names: Induction
names: Similarity
messages: Amidase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).
messages: Belongs to the amidase family.
messages: Highly expressed under trichothecene-producing conditions.

229533:FGSG 07046
gene id: 229533:FGSG_07046
uniprot id: I1RSD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

229533:FGSG 12417
gene id: 229533:FGSG_12417
uniprot id: I1S6E6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 03956
gene id: 229533:FGSG_03956
uniprot id: I1RJE1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05494
gene id: 229533:FGSG_05494
uniprot id: I1RNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 10262
gene id: 229533:FGSG_10262
uniprot id: I1S0M9
names: Similarity
messages: Belongs to the RRP7 family.

229533:FGSG 04434
gene id: 229533:FGSG_04434
uniprot id: I1RKM3
names: Similarity
messages: Belongs to the peroxidase family.

229533:FGSG 08064
gene id: 229533:FGSG_08064
uniprot id: I1RV04
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09784
gene id: 229533:FGSG_09784
uniprot id: I1RZE5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

229533:FGSG 02573
gene id: 229533:FGSG_02573
uniprot id: I1RFT4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13546
gene id: 229533:FGSG_13546
uniprot id: I1S9L5
names: Similarity
messages: Belongs to the peptidase M4 family.

229533:FGSG 08129
gene id: 229533:FGSG_08129
uniprot id: I1RV66
names: Similarity
messages: Belongs to the UFD1 family.

229533:FGSG 08413
gene id: 229533:FGSG_08413
uniprot id: I1RVW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450.

229533:FGSG 00702
gene id: 229533:FGSG_00702
uniprot id: I1RB03
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GT2 glycosyltransferase family.
messages: Cell membrane
messages: Expression is induced during hyphal growth.
messages: Glycosyltransferase involved in the maintenance of the outermost surface of the fungal cell wall (PubMed:29020037). Likely functions in the synthesis of a currently unknown, potentially minor but widespread, extracellular or outer cell wall polysaccharide which plays a key role in facilitating many interactions between plants and fungi by enabling hyphal growth on solid matrices (PubMed:29020037).
messages: Severely impairs hyphal growth and pathogenicity on wheat leaves (PubMed:29020037). Does not affect adhesion to leaf surfaces (PubMed:29020037). Leads to constitutive overexpression of several transmembrane and secreted proteins, including an important LysM-domain chitin-binding virulence effector, LysM (PubMed:29020037).
messages: cell wall

229533:FGSG 05607
gene id: 229533:FGSG_05607
uniprot id: I1RNM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 05346
gene id: 229533:FGSG_05346
uniprot id: I1RMZ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10026
gene id: 229533:FGSG_10026
uniprot id: I1S014
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00509
gene id: 229533:FGSG_00509
uniprot id: I1RAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

229533:FGSG 07259
gene id: 229533:FGSG_07259
uniprot id: I1RSX2
names: Similarity
messages: Belongs to the isochorismatase family.

229533:FGSG 01699
gene id: 229533:FGSG_01699
uniprot id: I1RDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

229533:FGSG 09594
gene id: 229533:FGSG_09594
uniprot id: I1RYY1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04268
gene id: 229533:FGSG_04268
uniprot id: I1RK75
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

229533:FGSG 02181
gene id: 229533:FGSG_02181
uniprot id: I1RET0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: Decreases virulence in maize stalks (PubMed:36577386). No sensitivity to Congo Red (cell wall disrupting agent) or sodium dodecyl sulfate (SDS) (membrane disrupting agent), and in vitro cell population growth appears normal (PubMed:36577386).
messages: Interacts with Z.mays LRR5; the interaction is direct (PubMed:36577386). Interacts with Z.mays WAK17 isoform 2; the interaction is direct (PubMed:36577386).
messages: Membrane
messages: Secreted
messages: Suppresses host programmed cell death during infection by binding to Z.mays WAK17 isoform 2 and Z.mays LRR5, to prevent activation of Z.mays WAK17 isoform 1 and the downstream hypersensitive response.
messages: The CFEM domain mediates interactions with host proteins.

229533:FGSG 13281
gene id: 229533:FGSG_13281
uniprot id: I1S8V3
names: Similarity
messages: Belongs to the PDCD5 family.

229533:FGSG 08453
gene id: 229533:FGSG_08453
uniprot id: I1RW01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

229533:FGSG 06334
gene id: 229533:FGSG_06334
uniprot id: I1RQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

229533:FGSG 04214
gene id: 229533:FGSG_04214
uniprot id: I1RK26
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 02829
gene id: 229533:FGSG_02829
uniprot id: I1RGG8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 01652
gene id: 229533:FGSG_01652
uniprot id: I1RDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
messages: Membrane
messages: Nucleus membrane

229533:FGSG 09965
gene id: 229533:FGSG_09965
uniprot id: I1RZV9
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

229533:FGSG 11782
gene id: 229533:FGSG_11782
uniprot id: I1S4L4
names: Similarity
messages: Belongs to the MYBBP1A family.

229533:FGSG 10152
gene id: 229533:FGSG_10152
uniprot id: I1S0C9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10722
gene id: 229533:FGSG_10722
uniprot id: I1S1V0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 09081
gene id: 229533:FGSG_09081
uniprot id: V6RMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02301
gene id: 229533:FGSG_02301
uniprot id: I1RF35
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 11843
gene id: 229533:FGSG_11843
uniprot id: I1S4S5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 03610
gene id: 229533:FGSG_03610
uniprot id: I1RIH7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 00046
gene id: 229533:FGSG_00046
uniprot id: I1R9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ABC-type transporter; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). May be involved in the secretion of gramillins (Probable).
messages: Belongs to the ABC transporter superfamily. ABCC family.
messages: Cell membrane

229533:FGSG 00686
gene id: 229533:FGSG_00686
uniprot id: V6R1X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02202
gene id: 229533:FGSG_02202
uniprot id: I1REU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 10809
gene id: 229533:FGSG_10809
uniprot id: I1S228
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01618
gene id: 229533:FGSG_01618
uniprot id: I1RDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

229533:FGSG 03360
gene id: 229533:FGSG_03360
uniprot id: I1RHU5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02439
gene id: 229533:FGSG_02439
uniprot id: I1RFG5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06413
gene id: 229533:FGSG_06413
uniprot id: A0A1I9FX21
uniprot id: Q4I8P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.

229533:FGSG 04263
gene id: 229533:FGSG_04263
uniprot id: I1RK70
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

229533:FGSG 03920
gene id: 229533:FGSG_03920
uniprot id: I1RJB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03229
gene id: 229533:FGSG_03229
uniprot id: I1RHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

229533:FGSG 05141
gene id: 229533:FGSG_05141
uniprot id: I1RMF2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by guanine nucleotide-exchange factors (GEFs), and inactivated by GTPase-activating proteins (GAPs).
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Late endosome membrane
messages: Vacuole membrane
messages: Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (By similarity). RAB7 regulates the fusion of vacuoles and autophagosomes (PubMed:26177389). Required for ATG9 trafficking (PubMed:30044782).

229533:FGSG 04345
gene id: 229533:FGSG_04345
uniprot id: I1RKE3
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 04732
gene id: 229533:FGSG_04732
uniprot id: I1RLD7
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 02763
gene id: 229533:FGSG_02763
uniprot id: I1RGA5
names: Similarity
messages: Belongs to the DeSI family.

229533:FGSG 08851
gene id: 229533:FGSG_08851
uniprot id: I1RX10
names: Similarity
messages: Belongs to the PrpD family.

229533:FGSG 04919
gene id: 229533:FGSG_04919
uniprot id: I1RLV0
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

229533:FGSG 02112
gene id: 229533:FGSG_02112
uniprot id: I1REM0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06207
gene id: 229533:FGSG_06207
uniprot id: I1RQ68
names: Similarity
messages: Belongs to the GroES chaperonin family.

229533:FGSG 04119
gene id: 229533:FGSG_04119
uniprot id: I1RJT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 07112
gene id: 229533:FGSG_07112
uniprot id: I1RSJ1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

229533:FGSG 03328
gene id: 229533:FGSG_03328
uniprot id: I1RHR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 03802
gene id: 229533:FGSG_03802
uniprot id: I1RJ04
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 08405
gene id: 229533:FGSG_08405
uniprot id: I1RVW0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

229533:FGSG 02687
gene id: 229533:FGSG_02687
uniprot id: I1RG38
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 11300
gene id: 229533:FGSG_11300
uniprot id: I1S3C3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 10276
gene id: 229533:FGSG_10276
uniprot id: I1S0P0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

229533:FGSG 09226
gene id: 229533:FGSG_09226
uniprot id: I1RXZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

229533:FGSG 06527
gene id: 229533:FGSG_06527
uniprot id: I1RR22
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

229533:FGSG 06027
gene id: 229533:FGSG_06027
uniprot id: I1RPQ1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

229533:FGSG 01410
gene id: 229533:FGSG_01410
uniprot id: I1RCT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: actin patch

229533:FGSG 00040
gene id: 229533:FGSG_00040
uniprot id: I1R9A9
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Methyltransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 04703
gene id: 229533:FGSG_04703
uniprot id: I1RLB6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 03727
gene id: 229533:FGSG_03727
uniprot id: I1RIT3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01496
gene id: 229533:FGSG_01496
uniprot id: I1RD09
names: Similarity
messages: Belongs to the sulfatase family.

229533:FGSG 08937
gene id: 229533:FGSG_08937
uniprot id: I1RX85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

229533:FGSG 07940
gene id: 229533:FGSG_07940
uniprot id: I1RUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

229533:FGSG 11714
gene id: 229533:FGSG_11714
uniprot id: I1S4E7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the conversion of 4,4-dimethylfecosterol into fecosterol via 4-methylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methy…

229533:FGSG 06245
gene id: 229533:FGSG_06245
uniprot id: Q4I963
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
messages: Cytoplasm
messages: Nucleus matrix
messages: cytoskeleton

229533:FGSG 10385
gene id: 229533:FGSG_10385
uniprot id: I1S0Z3
names: Similarity
messages: Belongs to the actin family.

229533:FGSG 02781
gene id: 229533:FGSG_02781
uniprot id: I1RGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Cytoplasm

229533:FGSG 03315
gene id: 229533:FGSG_03315
uniprot id: I1RHQ4
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 03857
gene id: 229533:FGSG_03857
uniprot id: I1RJ54
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06735
gene id: 229533:FGSG_06735
uniprot id: I1RRK7
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

229533:FGSG 06757
gene id: 229533:FGSG_06757
uniprot id: I1RRM5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

229533:FGSG 05446
gene id: 229533:FGSG_05446
uniprot id: I1RN80
names: Similarity
messages: Belongs to the arginase family.

229533:FGSG 07331
gene id: 229533:FGSG_07331
uniprot id: I1RT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

229533:FGSG 11940
gene id: 229533:FGSG_11940
uniprot id: I1S522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

229533:FGSG 10538
gene id: 229533:FGSG_10538
uniprot id: I1S1D8
names: Similarity
messages: Belongs to the RutC family.

229533:FGSG 01941
gene id: 229533:FGSG_01941
uniprot id: I1RE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 04581
gene id: 229533:FGSG_04581
uniprot id: I1RL07
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02312
gene id: 229533:FGSG_02312
uniprot id: I1RF46
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 13640
gene id: 229533:FGSG_13640
uniprot id: I1S9V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Vacuole membrane

229533:FGSG 02019
gene id: 229533:FGSG_02019
uniprot id: I1RED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

229533:FGSG 10052
gene id: 229533:FGSG_10052
uniprot id: I1S038
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04135
gene id: 229533:FGSG_04135
uniprot id: I1RJV2
names: Similarity
messages: Belongs to the AAR2 family.

229533:FGSG 00276
gene id: 229533:FGSG_00276
uniprot id: I1R9W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

229533:FGSG 06349
gene id: 229533:FGSG_06349
uniprot id: I1RQK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 04273
gene id: 229533:FGSG_04273
uniprot id: I1RK79
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

229533:FGSG 07873
gene id: 229533:FGSG_07873
uniprot id: I1RUI0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05303
gene id: 229533:FGSG_05303
uniprot id: I1RMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

229533:FGSG 11364
gene id: 229533:FGSG_11364
uniprot id: I1S3I1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06158
gene id: 229533:FGSG_06158
uniprot id: I1RQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

229533:FGSG 04243
gene id: 229533:FGSG_04243
uniprot id: I1RK55
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

229533:FGSG 00045
gene id: 229533:FGSG_00045
uniprot id: I1R9B2
names: Function
names: Similarity
messages: AB hydrolase superfamily protein; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
messages: Belongs to the AB hydrolase superfamily.

229533:FGSG 10362
gene id: 229533:FGSG_10362
uniprot id: I1S0X1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

229533:FGSG 04356
gene id: 229533:FGSG_04356
uniprot id: I1RKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01190
gene id: 229533:FGSG_01190
uniprot id: I1RC87
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00773
gene id: 229533:FGSG_00773
uniprot id: I1RB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

229533:FGSG 06342
gene id: 229533:FGSG_06342
uniprot id: I1RQJ7
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

229533:FGSG 02607
gene id: 229533:FGSG_02607
uniprot id: I1RFW5
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 05028
gene id: 229533:FGSG_05028
uniprot id: I1RM49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.

229533:FGSG 06352
gene id: 229533:FGSG_06352
uniprot id: I1RQK7
names: Similarity
messages: Belongs to the RPAP1 family.

229533:FGSG 07519
gene id: 229533:FGSG_07519
uniprot id: I1RTL0
names: Similarity
messages: Belongs to the NUP family.

229533:FGSG 08672
gene id: 229533:FGSG_08672
uniprot id: I1RWJ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12489
gene id: 229533:FGSG_12489
uniprot id: I1S6L7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 06273
gene id: 229533:FGSG_06273
uniprot id: I1RQD2
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 00302
gene id: 229533:FGSG_00302
uniprot id: I1R9Y6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10757
gene id: 229533:FGSG_10757
uniprot id: I1S1X9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

229533:FGSG 09796
gene id: 229533:FGSG_09796
uniprot id: I1RZF7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 10659
gene id: 229533:FGSG_10659
uniprot id: I1S1P8
names: Similarity
messages: Belongs to the asparaginase 1 family.

229533:FGSG 02681
gene id: 229533:FGSG_02681
uniprot id: I1RG32
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

229533:FGSG 00383
gene id: 229533:FGSG_00383
uniprot id: I1RA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

229533:FGSG 09444
gene id: 229533:FGSG_09444
uniprot id: V6RN69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

229533:FGSG 11179
gene id: 229533:FGSG_11179
uniprot id: I1S318
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 06694
gene id: 229533:FGSG_06694
uniprot id: I1RRH3
names: Similarity
messages: Belongs to the NRDE2 family.

229533:FGSG 10293
gene id: 229533:FGSG_10293
uniprot id: I1S0Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

229533:FGSG 01311
gene id: 229533:FGSG_01311
uniprot id: I1RCJ4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 00589
gene id: 229533:FGSG_00589
uniprot id: I1RAQ4
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

229533:FGSG 04983
gene id: 229533:FGSG_04983
uniprot id: I1RM10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

229533:FGSG 11215
gene id: 229533:FGSG_11215
uniprot id: I1S350
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 03735
gene id: 229533:FGSG_03735
uniprot id: I1RIU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 02322
gene id: 229533:FGSG_02322
uniprot id: I1RF56
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).
messages: Leads to pink mycelia in young cultures which turn red in older cultures, suggesting a delayed production of aurofusarin (PubMed:21296881).
messages: Rubrofusarin-specific efflux pump; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).

229533:FGSG 11988
gene id: 229533:FGSG_11988
uniprot id: I1S570
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07550
gene id: 229533:FGSG_07550
uniprot id: I1RTN7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10790
gene id: 229533:FGSG_10790
uniprot id: I1S210
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 01449
gene id: 229533:FGSG_01449
uniprot id: I1RCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

229533:FGSG 09807
gene id: 229533:FGSG_09807
uniprot id: I1RZG7
names: Similarity
messages: Belongs to the CEF1 family.

229533:FGSG 02165
gene id: 229533:FGSG_02165
uniprot id: V6QYX9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 04321
gene id: 229533:FGSG_04321
uniprot id: I1RKC1
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

229533:FGSG 06464
gene id: 229533:FGSG_06464
uniprot id: I1RQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 13910
gene id: 229533:FGSG_13910
uniprot id: I1SAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 05670
gene id: 229533:FGSG_05670
uniprot id: V6RIE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane

229533:FGSG 07284
gene id: 229533:FGSG_07284
uniprot id: I1RSZ6
names: Similarity
messages: Belongs to the alpha-actinin family.

229533:FGSG 08540
gene id: 229533:FGSG_08540
uniprot id: I1RW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 10741
gene id: 229533:FGSG_10741
uniprot id: I1S1W6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 05095
gene id: 229533:FGSG_05095
uniprot id: I1RMA8
names: Function
names: Similarity
messages: Belongs to the peptidase S1C family.
messages: Nuclear serine protease which mediates apoptosis.

229533:FGSG 12821
gene id: 229533:FGSG_12821
uniprot id: I1S7J8
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 04308
gene id: 229533:FGSG_04308
uniprot id: I1RKB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

229533:FGSG 05364
gene id: 229533:FGSG_05364
uniprot id: I1RN07
names: Function
names: Similarity
messages: Belongs to the BYE1 family.
messages: Negative regulator of transcription elongation.

229533:FGSG 04368
gene id: 229533:FGSG_04368
uniprot id: I1RKG6
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 04700
gene id: 229533:FGSG_04700
uniprot id: I1RLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00667
gene id: 229533:FGSG_00667
uniprot id: I1RAX3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09930
gene id: 229533:FGSG_09930
uniprot id: I1RZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

229533:FGSG 11124
gene id: 229533:FGSG_11124
uniprot id: I1S2W8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07161
gene id: 229533:FGSG_07161
uniprot id: I1RSN5
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

229533:FGSG 09351
gene id: 229533:FGSG_09351
uniprot id: I1RYA9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 07415
gene id: 229533:FGSG_07415
uniprot id: I1RTB4
names: Similarity
messages: Belongs to the SMAP family.

229533:FGSG 13674
gene id: 229533:FGSG_13674
uniprot id: I1S9Z3
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

229533:FGSG 13587
gene id: 229533:FGSG_13587
uniprot id: I1S9Q6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 07371
gene id: 229533:FGSG_07371
uniprot id: I1RT72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

229533:FGSG 02854
gene id: 229533:FGSG_02854
uniprot id: I1RGI7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09843
gene id: 229533:FGSG_09843
uniprot id: I1RZJ6
names: Similarity
messages: Belongs to the CWC22 family.

229533:FGSG 00684
gene id: 229533:FGSG_00684
uniprot id: I1RAY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 13552
gene id: 229533:FGSG_13552
uniprot id: I1S9M1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

229533:FGSG 09505
gene id: 229533:FGSG_09505
uniprot id: I1RYP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

229533:FGSG 10344
gene id: 229533:FGSG_10344
uniprot id: I1S0V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

229533:FGSG 08336
gene id: 229533:FGSG_08336
uniprot id: I1RVQ1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01502
gene id: 229533:FGSG_01502
uniprot id: I1RD15
names: Similarity
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.

229533:FGSG 00039
gene id: 229533:FGSG_00039
uniprot id: I1R9A8
names: Function
messages: Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 06577
gene id: 229533:FGSG_06577
uniprot id: I1RR65
names: Similarity
messages: Belongs to the BolA/IbaG family.

229533:FGSG 06863
gene id: 229533:FGSG_06863
uniprot id: V6REG9
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.

229533:FGSG 04856
gene id: 229533:FGSG_04856
uniprot id: I1RLP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

229533:FGSG 06508
gene id: 229533:FGSG_06508
uniprot id: I1RR06
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10881
gene id: 229533:FGSG_10881
uniprot id: A0A1C3YK94
uniprot id: Q4HVX7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

229533:FGSG 01624
gene id: 229533:FGSG_01624
uniprot id: I1RDD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 09989
gene id: 229533:FGSG_09989
uniprot id: V6RXB3
names: Similarity
messages: Belongs to the MYG1 family.

229533:FGSG 07226
gene id: 229533:FGSG_07226
uniprot id: I1RSU2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

229533:FGSG 03456
gene id: 229533:FGSG_03456
uniprot id: I1RI34
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

229533:FGSG 08518
gene id: 229533:FGSG_08518
uniprot id: V6RLH0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01954
gene id: 229533:FGSG_01954
uniprot id: I1RE75
names: Similarity
messages: Belongs to the VPS52 family.

229533:FGSG 11822
gene id: 229533:FGSG_11822
uniprot id: I1S4Q4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 06867
gene id: 229533:FGSG_06867
uniprot id: I1RRW7
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

229533:FGSG 00371
gene id: 229533:FGSG_00371
uniprot id: I1RA47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

229533:FGSG 13870
gene id: 229533:FGSG_13870
uniprot id: I1SAI9
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

229533:FGSG 07175
gene id: 229533:FGSG_07175
uniprot id: I1RSP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

229533:FGSG 05243
gene id: 229533:FGSG_05243
uniprot id: I1RMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 09984
gene id: 229533:FGSG_09984
uniprot id: V6RQW4
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

229533:FGSG 10320
gene id: 229533:FGSG_10320
uniprot id: I1S0T2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

229533:FGSG 07310
gene id: 229533:FGSG_07310
uniprot id: I1RT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus

229533:FGSG 01020
gene id: 229533:FGSG_01020
uniprot id: I1RBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

229533:FGSG 06627
gene id: 229533:FGSG_06627
uniprot id: I1RRB0
names: Similarity
messages: Belongs to the MAPRE family.

229533:FGSG 02767
gene id: 229533:FGSG_02767
uniprot id: I1RGA9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01730
gene id: 229533:FGSG_01730
uniprot id: I1RDM1
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

229533:FGSG 10267
gene id: 229533:FGSG_10267
uniprot id: I1S0N3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

229533:FGSG 06954
gene id: 229533:FGSG_06954
uniprot id: I1RS46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

229533:FGSG 01007
gene id: 229533:FGSG_01007
uniprot id: A0A1I9EXD2
uniprot id: Q4IP51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
messages: The GINS complex plays an essential role in the initiation of DNA replication.

229533:FGSG 07339
gene id: 229533:FGSG_07339
uniprot id: I1RT45
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm

229533:FGSG 06214
gene id: 229533:FGSG_06214
uniprot id: I1RQ75
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

229533:FGSG 02848
gene id: 229533:FGSG_02848
uniprot id: I1RGI2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

229533:FGSG 07058
gene id: 229533:FGSG_07058
uniprot id: I1RSE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

229533:FGSG 10793
gene id: 229533:FGSG_10793
uniprot id: I1S212
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

229533:FGSG 13276
gene id: 229533:FGSG_13276
uniprot id: I1S8U8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00036
gene id: 229533:FGSG_00036
uniprot id: I1R9A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.
messages: Fatty acid synthase is composed of alpha and beta subunits.
messages: Fatty acid synthase subunit alpha; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 13052
gene id: 229533:FGSG_13052
uniprot id: I1S874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Membrane
messages: Mitochondrion

229533:FGSG 08972
gene id: 229533:FGSG_08972
uniprot id: I1RXB2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01686
gene id: 229533:FGSG_01686
uniprot id: V6R556
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 07502
gene id: 229533:FGSG_07502
uniprot id: I1RTJ4
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 09439
gene id: 229533:FGSG_09439
uniprot id: I1RYI6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

229533:FGSG 07564
gene id: 229533:FGSG_07564
uniprot id: I1RTQ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00504
gene id: 229533:FGSG_00504
uniprot id: I1RAH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

229533:FGSG 10755
gene id: 229533:FGSG_10755
uniprot id: I1S1X7
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 00861
gene id: 229533:FGSG_00861
uniprot id: I1RBE4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

229533:FGSG 03546
gene id: 229533:FGSG_03546
uniprot id: I1RIB5
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

229533:FGSG 02397
gene id: 229533:FGSG_02397
uniprot id: A0A0E0RTV6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).
messages: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).
messages: Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793).

229533:FGSG 01006
gene id: 229533:FGSG_01006
uniprot id: I1RBR9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00044
gene id: 229533:FGSG_00044
uniprot id: I1R9B1
names: Function
names: Similarity
messages: AB hydrolase superfamily protein; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
messages: Belongs to the AB hydrolase superfamily.

229533:FGSG 00807
gene id: 229533:FGSG_00807
uniprot id: I1RB97
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Secreted

229533:FGSG 03307
gene id: 229533:FGSG_03307
uniprot id: I1RHP6
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 02561
gene id: 229533:FGSG_02561
uniprot id: I1RFS3
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 02320
gene id: 229533:FGSG_02320
uniprot id: I1RF54
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression correlates with aurofusarin production and is restricted to vegetative mycelia (PubMed:16461721). Expression is negatively regulated by the MAPK-mediated osmotic stress-signaling pathway (PubMed:17897620).
messages: Leads to an albinos phenotype (PubMed:16879655). Inactivates the expression of the aurofusarin biosynthetic gene cluster (PubMed:16879655, PubMed:16461721).
messages: Nucleus
messages: Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:16879655, PubMed:16461721).

229533:FGSG 11487
gene id: 229533:FGSG_11487
uniprot id: A0A1I9FYC9
uniprot id: I1S3T9
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.
messages: Expression is under the control of transcription factor XYR1 and highly induced by xylan, carboxymethylcellulose (CMC), and hop cell wall.
messages: Secreted
messages: Weakly inhibited by the wheat xylanase inhibiting protein I (XIP-I).

229533:FGSG 09034
gene id: 229533:FGSG_09034
uniprot id: A0A1I9FJP4
uniprot id: Q4I174
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

229533:FGSG 07289
gene id: 229533:FGSG_07289
uniprot id: I1RT01
names: Similarity
messages: Belongs to the PAF1 family.

229533:FGSG 10210
gene id: 229533:FGSG_10210
uniprot id: I1S0I2
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 09454
gene id: 229533:FGSG_09454
uniprot id: I1RYJ8
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 13569
gene id: 229533:FGSG_13569
uniprot id: I1S9N8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02874
gene id: 229533:FGSG_02874
uniprot id: I1RGK4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01760
gene id: 229533:FGSG_01760
uniprot id: I1RDP6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11848
gene id: 229533:FGSG_11848
uniprot id: I1S4T0
names: Similarity
messages: Belongs to the VPS8 family.

229533:FGSG 09263
gene id: 229533:FGSG_09263
uniprot id: I1RY32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

229533:FGSG 09019
gene id: 229533:FGSG_09019
uniprot id: I1RXF3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08298
gene id: 229533:FGSG_08298
uniprot id: I1RVL7
names: Similarity
messages: Belongs to the MNN1/MNT family.

229533:FGSG 00491
gene id: 229533:FGSG_00491
uniprot id: V6QUV7
names: Similarity
messages: Belongs to the calreticulin family.

229533:FGSG 01794
gene id: 229533:FGSG_01794
uniprot id: I1RDS8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07336
gene id: 229533:FGSG_07336
uniprot id: I1RT42
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

229533:FGSG 08710
gene id: 229533:FGSG_08710
uniprot id: I1RWN4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 09734
gene id: 229533:FGSG_09734
uniprot id: I1RZA4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06165
gene id: 229533:FGSG_06165
uniprot id: I1RQ31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

229533:FGSG 00172
gene id: 229533:FGSG_00172
uniprot id: I1R9M3
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 06081
gene id: 229533:FGSG_06081
uniprot id: I1RPV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

229533:FGSG 10950
gene id: 229533:FGSG_10950
uniprot id: I1S2F7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 06847
gene id: 229533:FGSG_06847
uniprot id: V6REE9
names: Similarity
messages: Belongs to the 14-3-3 family.

229533:FGSG 03311
gene id: 229533:FGSG_03311
uniprot id: I1RHQ0
names: Similarity
names: Subunit
messages: Belongs to the mannitol dehydrogenase family.
messages: Monomer.

229533:FGSG 04683
gene id: 229533:FGSG_04683
uniprot id: I1RL97
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04853
gene id: 229533:FGSG_04853
uniprot id: I1RLP0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09726
gene id: 229533:FGSG_09726
uniprot id: I1RZ96
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06354
gene id: 229533:FGSG_06354
uniprot id: I1RQK9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03406
gene id: 229533:FGSG_03406
uniprot id: I1RHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pectinesterase family.
messages: Involved in maceration and soft-rotting of plant tissue.
messages: Secreted

229533:FGSG 00296
gene id: 229533:FGSG_00296
uniprot id: V6QU65
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

229533:FGSG 09535
gene id: 229533:FGSG_09535
uniprot id: I1RYS6
names: Similarity
messages: Belongs to the AHA1 family.

229533:FGSG 06850
gene id: 229533:FGSG_06850
uniprot id: I1RRV4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 00876
gene id: 229533:FGSG_00876
uniprot id: I1RBF7
names: Similarity
messages: Belongs to the PGA52 family.

229533:FGSG 06893
gene id: 229533:FGSG_06893
uniprot id: I1RRY9
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

229533:FGSG 10894
gene id: 229533:FGSG_10894
uniprot id: I1S2A8
names: Function
names: Similarity
messages: Belongs to the exportin family.
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

229533:FGSG 05844
gene id: 229533:FGSG_05844
uniprot id: I1RP87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

229533:FGSG 06587
gene id: 229533:FGSG_06587
uniprot id: I1RR73
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

229533:FGSG 06849
gene id: 229533:FGSG_06849
uniprot id: A0A1I9FN07
uniprot id: Q4I7F9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
messages: Component of the U5 snRNP complex.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 04720
gene id: 229533:FGSG_04720
uniprot id: I1RLC8
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 03322
gene id: 229533:FGSG_03322
uniprot id: I1RHR0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10347
gene id: 229533:FGSG_10347
uniprot id: I1S0V7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

229533:FGSG 07368
gene id: 229533:FGSG_07368
uniprot id: I1RT69
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04579
gene id: 229533:FGSG_04579
uniprot id: I1RL05
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10309
gene id: 229533:FGSG_10309
uniprot id: I1S0S2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

229533:FGSG 01480
gene id: 229533:FGSG_01480
uniprot id: I1RCZ3
names: Similarity
messages: Belongs to the SEN54 family.

229533:FGSG 08347
gene id: 229533:FGSG_08347
uniprot id: I1RVQ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04355
gene id: 229533:FGSG_04355
uniprot id: I1RKF3
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

229533:FGSG 07395
gene id: 229533:FGSG_07395
uniprot id: I1RT94
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

229533:FGSG 04274
gene id: 229533:FGSG_04274
uniprot id: I1RK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 02215
gene id: 229533:FGSG_02215
uniprot id: I1REW1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00866
gene id: 229533:FGSG_00866
uniprot id: I1RBE8
names: Similarity
messages: Belongs to the lipin family.

229533:FGSG 00798
gene id: 229533:FGSG_00798
uniprot id: V6QUW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the small ribosomal subunit.
messages: Cytoplasm
messages: Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.

229533:FGSG 11036
gene id: 229533:FGSG_11036
uniprot id: I1S2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the faeC family.
messages: Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.
messages: Secreted

229533:FGSG 04164
gene id: 229533:FGSG_04164
uniprot id: A0A1I9FCP5
uniprot id: Q4IF44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus
messages: Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.

229533:FGSG 09156
gene id: 229533:FGSG_09156
uniprot id: I1RXT1
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

229533:FGSG 10351
gene id: 229533:FGSG_10351
uniprot id: I1S0W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

229533:FGSG 06353
gene id: 229533:FGSG_06353
uniprot id: I1RQK8
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

229533:FGSG 11038
gene id: 229533:FGSG_11038
uniprot id: I1S2N8
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08610
gene id: 229533:FGSG_08610
uniprot id: I1RWE4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

229533:FGSG 05848
gene id: 229533:FGSG_05848
uniprot id: I1RP91
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09983
gene id: 229533:FGSG_09983
uniprot id: I1RZX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.

229533:FGSG 03396
gene id: 229533:FGSG_03396
uniprot id: I1RHY0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03934
gene id: 229533:FGSG_03934
uniprot id: I1RJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00034
gene id: 229533:FGSG_00034
uniprot id: I1R9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03427
gene id: 229533:FGSG_03427
uniprot id: I1RI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 04872
gene id: 229533:FGSG_04872
uniprot id: I1RLQ8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 09935
gene id: 229533:FGSG_09935
uniprot id: I1RZT1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 12330
gene id: 229533:FGSG_12330
uniprot id: I1S659
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

229533:FGSG 01745
gene id: 229533:FGSG_01745
uniprot id: I1RDN5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 03878
gene id: 229533:FGSG_03878
uniprot id: I1RJ71
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00815
gene id: 229533:FGSG_00815
uniprot id: I1RBA4
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

229533:FGSG 03412
gene id: 229533:FGSG_03412
uniprot id: I1RHZ3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02286
gene id: 229533:FGSG_02286
uniprot id: I1RF23
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 00530
gene id: 229533:FGSG_00530
uniprot id: I1RAJ9
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

229533:FGSG 08134
gene id: 229533:FGSG_08134
uniprot id: I1RV70
names: Similarity
messages: Belongs to the rtf2 family.

229533:FGSG 06022
gene id: 229533:FGSG_06022
uniprot id: I1RPP6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

229533:FGSG 06246
gene id: 229533:FGSG_06246
uniprot id: I1RQA5
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

229533:FGSG 08784
gene id: 229533:FGSG_08784
uniprot id: I1RWU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

229533:FGSG 08573
gene id: 229533:FGSG_08573
uniprot id: I1RWB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

229533:FGSG 08531
gene id: 229533:FGSG_08531
uniprot id: A0A1I9F923
uniprot id: Q4I2M7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Palmitoyltransferase specific for Ras proteins.
messages: The DHHC domain is required for palmitoyltransferase activity.

229533:FGSG 08935
gene id: 229533:FGSG_08935
uniprot id: I1RX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

229533:FGSG 03616
gene id: 229533:FGSG_03616
uniprot id: I1RII3
names: Similarity
messages: Belongs to the RNase T2 family.
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 05389
gene id: 229533:FGSG_05389
uniprot id: I1RN28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

229533:FGSG 01300
gene id: 229533:FGSG_01300
uniprot id: I1RCI4
names: Similarity
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.

229533:FGSG 12883
gene id: 229533:FGSG_12883
uniprot id: I1S7Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

229533:FGSG 07610
gene id: 229533:FGSG_07610
uniprot id: I1RTU3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01567
gene id: 229533:FGSG_01567
uniprot id: A0A1I9EZ77
uniprot id: Q4IMJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 09531
gene id: 229533:FGSG_09531
uniprot id: I1RYS2
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

229533:FGSG 10780
gene id: 229533:FGSG_10780
uniprot id: I1S200
names: Similarity
messages: Belongs to the RMD1/sif2 family.

229533:FGSG 09646
gene id: 229533:FGSG_09646
uniprot id: I1RZ28
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 09839
gene id: 229533:FGSG_09839
uniprot id: I1RZJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

229533:FGSG 09482
gene id: 229533:FGSG_09482
uniprot id: I1RYM5
names: Cofactor
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

229533:FGSG 05330
gene id: 229533:FGSG_05330
uniprot id: I1RMX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

229533:FGSG 08158
gene id: 229533:FGSG_08158
uniprot id: I1RV93
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

229533:FGSG 00940
gene id: 229533:FGSG_00940
uniprot id: A0A1I9EX46
uniprot id: Q4IPB8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 09576
gene id: 229533:FGSG_09576
uniprot id: I1RYW5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10651
gene id: 229533:FGSG_10651
uniprot id: I1S1P0
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 09382
gene id: 229533:FGSG_09382
uniprot id: I1RYD6
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 06924
gene id: 229533:FGSG_06924
uniprot id: I1RS18
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

229533:FGSG 00675
gene id: 229533:FGSG_00675
uniprot id: I1RAY1
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG14 family.
messages: Coiled-Coils at the N-terminal half are essential for autophagy (By similarity).
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I (By similarity).
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).
messages: Vacuole membrane

229533:FGSG 06816
gene id: 229533:FGSG_06816
uniprot id: I1RRS8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

229533:FGSG 04546
gene id: 229533:FGSG_04546
uniprot id: I1RKX5
names: Similarity
messages: Belongs to the peptidase S10 family.

229533:FGSG 01876
gene id: 229533:FGSG_01876
uniprot id: I1RE05
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 03024
gene id: 229533:FGSG_03024
uniprot id: I1RGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 05222
gene id: 229533:FGSG_05222
uniprot id: I1RMM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

229533:FGSG 08439
gene id: 229533:FGSG_08439
uniprot id: I1RVZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

229533:FGSG 01092
gene id: 229533:FGSG_01092
uniprot id: A0A1I9EXN1
uniprot id: Q4INW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.

229533:FGSG 08875
gene id: 229533:FGSG_08875
uniprot id: A0A1I9F7Y5
uniprot id: Q4I1N3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).
messages: Belongs to the APS kinase family.
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Homohexamer. Dimer of trimers.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the sulfate adenylyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.

229533:FGSG 10998
gene id: 229533:FGSG_10998
uniprot id: I1S2K2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Binds 1 FAD per subunit in a bicovalent manner.
messages: Catalyzes the selective oxidation of C1 hydroxyl moieties on chitooligosaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Chitooligosaccharides are homo- or heterooligomers of N-acetylglucosamine (GlcNAc) and D-glucosamine which are linked through beta-1,4-glycosidic bonds. For optimal substrate binding at least 2 GlcNAc units are needed, and chitooligosaccharide oxidase is most efficient on chitobiose, chitotriose and chitotetraose.
messages: Secreted
messages: The FAD cofactor is bound via a bicovalent 6-S-cysteinyl, 8alpha-N1-histidyl FAD linkage.

229533:FGSG 03072
gene id: 229533:FGSG_03072
uniprot id: I1RH33
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

229533:FGSG 06156
gene id: 229533:FGSG_06156
uniprot id: I1RQ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

229533:FGSG 06117
gene id: 229533:FGSG_06117
uniprot id: I1RPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 4 family.
messages: Secreted

229533:FGSG 02204
gene id: 229533:FGSG_02204
uniprot id: I1REV1
names: Similarity
messages: Belongs to the peptidase S28 family.

229533:FGSG 06397
gene id: 229533:FGSG_06397
uniprot id: I1RQQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 07771
gene id: 229533:FGSG_07771
uniprot id: I1RU87
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04369
gene id: 229533:FGSG_04369
uniprot id: I1RKG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 09788
gene id: 229533:FGSG_09788
uniprot id: I1RZE9
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 08070
gene id: 229533:FGSG_08070
uniprot id: I1RV10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

229533:FGSG 06231
gene id: 229533:FGSG_06231
uniprot id: I1RQ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Nucleus

229533:FGSG 08674
gene id: 229533:FGSG_08674
uniprot id: I1RWK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.
messages: Mitochondrion inner membrane

229533:FGSG 11557
gene id: 229533:FGSG_11557
uniprot id: I1S405
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 07860
gene id: 229533:FGSG_07860
uniprot id: I1RUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

229533:FGSG 08810
gene id: 229533:FGSG_08810
uniprot id: I1RWX4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08980
gene id: 229533:FGSG_08980
uniprot id: V6RM09
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 02525
gene id: 229533:FGSG_02525
uniprot id: I1RFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

229533:FGSG 01037
gene id: 229533:FGSG_01037
uniprot id: V6QVM5
names: Similarity
messages: Belongs to the IUNH family.

229533:FGSG 09509
gene id: 229533:FGSG_09509
uniprot id: I1RYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

229533:FGSG 01100
gene id: 229533:FGSG_01100
uniprot id: I1RC01
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01435
gene id: 229533:FGSG_01435
uniprot id: I1RCV3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07938
gene id: 229533:FGSG_07938
uniprot id: I1RUN8
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

229533:FGSG 04799
gene id: 229533:FGSG_04799
uniprot id: I1RLJ6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06220
gene id: 229533:FGSG_06220
uniprot id: I1RQ81
names: Similarity
messages: Belongs to the eIF-2-alpha family.

229533:FGSG 01167
gene id: 229533:FGSG_01167
uniprot id: I1RC64
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

229533:FGSG 07692
gene id: 229533:FGSG_07692
uniprot id: I1RU18
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

229533:FGSG 06529
gene id: 229533:FGSG_06529
uniprot id: Q4I8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
messages: Nucleus

229533:FGSG 04085
gene id: 229533:FGSG_04085
uniprot id: I1RJQ5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

229533:FGSG 04030
gene id: 229533:FGSG_04030
uniprot id: Q4IFH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
messages: Nucleus

229533:FGSG 00765
gene id: 229533:FGSG_00765
uniprot id: I1RB58
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 09913
gene id: 229533:FGSG_09913
uniprot id: V6RRC5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02534
gene id: 229533:FGSG_02534
uniprot id: I1RFQ0
names: Similarity
messages: Belongs to the SAP18 family.

229533:FGSG 01739
gene id: 229533:FGSG_01739
uniprot id: I1RDM9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 10884
gene id: 229533:FGSG_10884
uniprot id: I1S298
names: Similarity
messages: Belongs to the fructosamine kinase family.

229533:FGSG 11270
gene id: 229533:FGSG_11270
uniprot id: I1S395
names: Similarity
names: Subunit
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
messages: Homotetramer.

229533:FGSG 00369
gene id: 229533:FGSG_00369
uniprot id: I1RA45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

229533:FGSG 07105
gene id: 229533:FGSG_07105
uniprot id: I1RSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

229533:FGSG 10853
gene id: 229533:FGSG_10853
uniprot id: I1S267
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

229533:FGSG 10327
gene id: 229533:FGSG_10327
uniprot id: I1S0T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 09960
gene id: 229533:FGSG_09960
uniprot id: I1RZV5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 07248
gene id: 229533:FGSG_07248
uniprot id: A0A1I9FJB8
uniprot id: Q4I6B0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

229533:FGSG 05659
gene id: 229533:FGSG_05659
uniprot id: I1RNS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 12444
gene id: 229533:FGSG_12444
uniprot id: I1S6H3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

229533:FGSG 08084
gene id: 229533:FGSG_08084
uniprot id: I1RV24
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Highly expressed under trichothecene-producing conditions.
messages: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat.
messages: Membrane

229533:FGSG 00731
gene id: 229533:FGSG_00731
uniprot id: I1RB26
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

229533:FGSG 06687
gene id: 229533:FGSG_06687
uniprot id: A0A1I9FPZ1
uniprot id: Q4I7X1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs.
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

229533:FGSG 09000
gene id: 229533:FGSG_09000
uniprot id: I1RXD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

229533:FGSG 01284
gene id: 229533:FGSG_01284
uniprot id: I1RCH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane

229533:FGSG 06201
gene id: 229533:FGSG_06201
uniprot id: I1RQ63
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

229533:FGSG 02987
gene id: 229533:FGSG_02987
uniprot id: I1RGV7
names: Similarity
messages: Belongs to the tannase family.

229533:FGSG 09964
gene id: 229533:FGSG_09964
uniprot id: I1RZV8
names: Similarity
messages: Belongs to the AFG1 ATPase family.

229533:FGSG 00493
gene id: 229533:FGSG_00493
uniprot id: I1RAG5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

229533:FGSG 00608
gene id: 229533:FGSG_00608
uniprot id: I1RAS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

229533:FGSG 01371
gene id: 229533:FGSG_01371
uniprot id: I1RCP7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

229533:FGSG 10464
gene id: 229533:FGSG_10464
uniprot id: I1S166
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
messages: Binds 1 phosphopantetheine covalently.
messages: Expressed during sexual development (PubMed:16278459). Is not expressed during infection of wheat plants (PubMed:23290226). Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes (PubMed:22252016).
messages: Leads to significant increase in growth (PubMed:16278459). Abolishes the production of fusarielins F, G and H (PubMed:22252016, PubMed:27983606).
messages: Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (MET) domain that transfers methyl groups to the growing polyketide; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (Probable). Lacks an active enoyl reductase (ER) domain that reduces enoyl groups to alkyl groups, and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5 (Probable).
messages: Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606).

229533:FGSG 05954
gene id: 229533:FGSG_05954
uniprot id: I1RPI3
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

229533:FGSG 00825
gene id: 229533:FGSG_00825
uniprot id: I1RBB3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

229533:FGSG 10823
gene id: 229533:FGSG_10823
uniprot id: I1S239
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06644
gene id: 229533:FGSG_06644
uniprot id: I1RRC6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06636
gene id: 229533:FGSG_06636
uniprot id: I1RRB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

229533:FGSG 01320
gene id: 229533:FGSG_01320
uniprot id: I1RCK2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

229533:FGSG 09159
gene id: 229533:FGSG_09159
uniprot id: I1RXT4
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 06480
gene id: 229533:FGSG_06480
uniprot id: I1RQX9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

229533:FGSG 03370
gene id: 229533:FGSG_03370
uniprot id: I1RHV5
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 11453
gene id: 229533:FGSG_11453
uniprot id: I1S3Q8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07024
gene id: 229533:FGSG_07024
uniprot id: I1RSB0
names: Subcellular Location Annotation
messages: Cell membrane

229533:FGSG 08831
gene id: 229533:FGSG_08831
uniprot id: I1RWZ1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01724
gene id: 229533:FGSG_01724
uniprot id: I1RDL5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04453
gene id: 229533:FGSG_04453
uniprot id: A0A1I9FGK4
uniprot id: Q4IEA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

229533:FGSG 03426
gene id: 229533:FGSG_03426
uniprot id: I1RI07
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 04591
gene id: 229533:FGSG_04591
uniprot id: I1RL14
names: Biotechnology
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 11815
gene id: 229533:FGSG_11815
uniprot id: I1S4P7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07374
gene id: 229533:FGSG_07374
uniprot id: I1RT75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

229533:FGSG 08047
gene id: 229533:FGSG_08047
uniprot id: I1RUY8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07926
gene id: 229533:FGSG_07926
uniprot id: I1RUM7
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

229533:FGSG 07239
gene id: 229533:FGSG_07239
uniprot id: I1RSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

229533:FGSG 00884
gene id: 229533:FGSG_00884
uniprot id: A0A1I9EX16
uniprot id: Q4IPH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 02567
gene id: 229533:FGSG_02567
uniprot id: A0A1I9F2V6
uniprot id: Q4IJP1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.

229533:FGSG 07959
gene id: 229533:FGSG_07959
uniprot id: I1RUQ7
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

229533:FGSG 07115
gene id: 229533:FGSG_07115
uniprot id: I1RSJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

229533:FGSG 06115
gene id: 229533:FGSG_06115
uniprot id: I1RPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

229533:FGSG 06832
gene id: 229533:FGSG_06832
uniprot id: I1RRU2
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 01453
gene id: 229533:FGSG_01453
uniprot id: I1RCX0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00947
gene id: 229533:FGSG_00947
uniprot id: I1RBL9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07206
gene id: 229533:FGSG_07206
uniprot id: I1RSS4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

229533:FGSG 06545
gene id: 229533:FGSG_06545
uniprot id: I1RR36
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 05064
gene id: 229533:FGSG_05064
uniprot id: I1RM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

229533:FGSG 05937
gene id: 229533:FGSG_05937
uniprot id: I1RPG8
names: Similarity
messages: Belongs to the serine esterase family.

229533:FGSG 00660
gene id: 229533:FGSG_00660
uniprot id: I1RAW7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

229533:FGSG 09280
gene id: 229533:FGSG_09280
uniprot id: V6RV57
names: Similarity
messages: Belongs to the FBPase class 1 family.

229533:FGSG 08714
gene id: 229533:FGSG_08714
uniprot id: I1RWN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

229533:FGSG 03775
gene id: 229533:FGSG_03775
uniprot id: I1RIX8
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 03814
gene id: 229533:FGSG_03814
uniprot id: I1RJ15
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05641
gene id: 229533:FGSG_05641
uniprot id: I1RNQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

229533:FGSG 01333
gene id: 229533:FGSG_01333
uniprot id: I1RCL4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

229533:FGSG 11654
gene id: 229533:FGSG_11654
uniprot id: I1S487
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05120
gene id: 229533:FGSG_05120
uniprot id: I1RMD1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04416
gene id: 229533:FGSG_04416
uniprot id: I1RKK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

229533:FGSG 12862
gene id: 229533:FGSG_12862
uniprot id: I1S7N7
names: Similarity
messages: Belongs to the TBCC family.

229533:FGSG 02645
gene id: 229533:FGSG_02645
uniprot id: I1RFZ7
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

229533:FGSG 09060
gene id: 229533:FGSG_09060
uniprot id: I1RXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05345
gene id: 229533:FGSG_05345
uniprot id: I1RMY9
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

229533:FGSG 08944
gene id: 229533:FGSG_08944
uniprot id: I1RX90
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

229533:FGSG 01927
gene id: 229533:FGSG_01927
uniprot id: I1RE53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

229533:FGSG 00300
gene id: 229533:FGSG_00300
uniprot id: I1R9Y4
names: Similarity
messages: Belongs to the ATPase delta chain family.

229533:FGSG 00364
gene id: 229533:FGSG_00364
uniprot id: I1RA41
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

229533:FGSG 07210
gene id: 229533:FGSG_07210
uniprot id: I1RSS7
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

229533:FGSG 05731
gene id: 229533:FGSG_05731
uniprot id: I1RNY5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11743
gene id: 229533:FGSG_11743
uniprot id: I1S4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

229533:FGSG 01792
gene id: 229533:FGSG_01792
uniprot id: I1RDS7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06974
gene id: 229533:FGSG_06974
uniprot id: I1RS61
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

229533:FGSG 00265
gene id: 229533:FGSG_00265
uniprot id: I1R9V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

229533:FGSG 08593
gene id: 229533:FGSG_08593
uniprot id: I1RWC9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

229533:FGSG 12349
gene id: 229533:FGSG_12349
uniprot id: I1S678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anthrone oxygenase family.
messages: Membrane

229533:FGSG 02045
gene id: 229533:FGSG_02045
uniprot id: I1REF7
names: Similarity
messages: Belongs to the complex I LYR family.

229533:FGSG 03931
gene id: 229533:FGSG_03931
uniprot id: I1RJC0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03553
gene id: 229533:FGSG_03553
uniprot id: I1RIC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

229533:FGSG 02485
gene id: 229533:FGSG_02485
uniprot id: I1RFK6
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

229533:FGSG 04662
gene id: 229533:FGSG_04662
uniprot id: I1RL79
names: Similarity
messages: Belongs to the ustYa family.

229533:FGSG 11250
gene id: 229533:FGSG_11250
uniprot id: I1S380
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00298
gene id: 229533:FGSG_00298
uniprot id: I1R9Y2
names: Similarity
messages: Belongs to the UPP synthase family.

229533:FGSG 09016
gene id: 229533:FGSG_09016
uniprot id: I1RXF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

229533:FGSG 03168
gene id: 229533:FGSG_03168
uniprot id: I1RHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 09240
gene id: 229533:FGSG_09240
uniprot id: I1RY12
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

229533:FGSG 00757
gene id: 229533:FGSG_00757
uniprot id: I1RB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

229533:FGSG 03172
gene id: 229533:FGSG_03172
uniprot id: I1RHC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

229533:FGSG 05395
gene id: 229533:FGSG_05395
uniprot id: I1RN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Nucleus

229533:FGSG 03591
gene id: 229533:FGSG_03591
uniprot id: I1RIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

229533:FGSG 05406
gene id: 229533:FGSG_05406
uniprot id: I1RN43
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

229533:FGSG 07551
gene id: 229533:FGSG_07551
uniprot id: I1RTN8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 08901
gene id: 229533:FGSG_08901
uniprot id: I1RX51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

229533:FGSG 11389
gene id: 229533:FGSG_11389
uniprot id: I1S3K2
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 01174
gene id: 229533:FGSG_01174
uniprot id: I1RC71
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

229533:FGSG 07784
gene id: 229533:FGSG_07784
uniprot id: I1RU99
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 00743
gene id: 229533:FGSG_00743
uniprot id: I1RB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 03214
gene id: 229533:FGSG_03214
uniprot id: I1RHG2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00015
gene id: 229533:FGSG_00015
uniprot id: I1R987
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 08871
gene id: 229533:FGSG_08871
uniprot id: I1RX25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 02279
gene id: 229533:FGSG_02279
uniprot id: I1RF16
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

229533:FGSG 10384
gene id: 229533:FGSG_10384
uniprot id: I1S0Z2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08121
gene id: 229533:FGSG_08121
uniprot id: I1RV59
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00323
gene id: 229533:FGSG_00323
uniprot id: I1RA06
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

229533:FGSG 09804
gene id: 229533:FGSG_09804
uniprot id: I1RZG4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10029
gene id: 229533:FGSG_10029
uniprot id: I1S017
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05128
gene id: 229533:FGSG_05128
uniprot id: I1RMD9
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 04592
gene id: 229533:FGSG_04592
uniprot id: I1RL15
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: Membrane
messages: Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 07329
gene id: 229533:FGSG_07329
uniprot id: I1RT36
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

229533:FGSG 09884
gene id: 229533:FGSG_09884
uniprot id: I1RZN4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08648
gene id: 229533:FGSG_08648
uniprot id: I1RWH8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

229533:FGSG 02571
gene id: 229533:FGSG_02571
uniprot id: I1RFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 09118
gene id: 229533:FGSG_09118
uniprot id: I1RXP4
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 05545
gene id: 229533:FGSG_05545
uniprot id: A0A1I9FTQ3
uniprot id: Q4IB63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
messages: Membrane

229533:FGSG 09266
gene id: 229533:FGSG_09266
uniprot id: I1RY35
names: Function
names: Induction
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.
messages: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).

229533:FGSG 10613
gene id: 229533:FGSG_10613
uniprot id: I1S1K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

229533:FGSG 05301
gene id: 229533:FGSG_05301
uniprot id: I1RMV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

229533:FGSG 03846
gene id: 229533:FGSG_03846
uniprot id: I1RJ45
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

229533:FGSG 05027
gene id: 229533:FGSG_05027
uniprot id: I1RM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

229533:FGSG 00905
gene id: 229533:FGSG_00905
uniprot id: I1RBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

229533:FGSG 09940
gene id: 229533:FGSG_09940
uniprot id: I1RZT6
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

229533:FGSG 03271
gene id: 229533:FGSG_03271
uniprot id: I1RHL2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10571
gene id: 229533:FGSG_10571
uniprot id: I1S1H0
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 00085
gene id: 229533:FGSG_00085
uniprot id: I1R9E9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06306
gene id: 229533:FGSG_06306
uniprot id: I1RQG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

229533:FGSG 09792
gene id: 229533:FGSG_09792
uniprot id: I1RZF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

229533:FGSG 02022
gene id: 229533:FGSG_02022
uniprot id: I1RED5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

229533:FGSG 05309
gene id: 229533:FGSG_05309
uniprot id: I1RMV9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04968
gene id: 229533:FGSG_04968
uniprot id: I1RLZ6
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 02584
gene id: 229533:FGSG_02584
uniprot id: A0A1I9F2M1
uniprot id: Q4IJM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

229533:FGSG 05082
gene id: 229533:FGSG_05082
uniprot id: I1RM97
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08390
gene id: 229533:FGSG_08390
uniprot id: I1RVU5
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

229533:FGSG 09654
gene id: 229533:FGSG_09654
uniprot id: I1RZ35
names: Similarity
messages: Belongs to the EIF1AD family.

229533:FGSG 07141
gene id: 229533:FGSG_07141
uniprot id: I1RSL8
names: Similarity
messages: Belongs to the importin alpha family.

229533:FGSG 05949
gene id: 229533:FGSG_05949
uniprot id: I1RPI0
names: Similarity
messages: Belongs to the TOP6A family.

229533:FGSG 07334
gene id: 229533:FGSG_07334
uniprot id: A0A1I9FGZ2
uniprot id: Q4I624
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FES1 family.
messages: Cytoplasm
messages: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).
messages: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.

229533:FGSG 06404
gene id: 229533:FGSG_06404
uniprot id: Q4I8Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
messages: Nucleus

229533:FGSG 12126
gene id: 229533:FGSG_12126
uniprot id: A0A098D8A0
names: Disruption Phenotype
names: Function
names: Induction
messages: Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).
messages: Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793, PubMed:16517624, PubMed:16751498).

229533:FGSG 04171
gene id: 229533:FGSG_04171
uniprot id: I1RJY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

229533:FGSG 10875
gene id: 229533:FGSG_10875
uniprot id: I1S289
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

229533:FGSG 01433
gene id: 229533:FGSG_01433
uniprot id: I1RCV1
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

229533:FGSG 10506
gene id: 229533:FGSG_10506
uniprot id: I1S1A6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02155
gene id: 229533:FGSG_02155
uniprot id: I1RER0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 07335
gene id: 229533:FGSG_07335
uniprot id: I1RT41
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

229533:FGSG 05084
gene id: 229533:FGSG_05084
uniprot id: I1RM99
names: Similarity
messages: Belongs to the germin family.

229533:FGSG 07744
gene id: 229533:FGSG_07744
uniprot id: I1RU61
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07397
gene id: 229533:FGSG_07397
uniprot id: I1RT96
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

229533:FGSG 09820
gene id: 229533:FGSG_09820
uniprot id: I1RZH8
names: Cofactor
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.

229533:FGSG 09311
gene id: 229533:FGSG_09311
uniprot id: V6RN31
names: Similarity
messages: Belongs to the PAL/histidase family.

229533:FGSG 09218
gene id: 229533:FGSG_09218
uniprot id: I1RXZ1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

229533:FGSG 03540
gene id: 229533:FGSG_03540
uniprot id: I1RIA9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 00437
gene id: 229533:FGSG_00437
uniprot id: I1RAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

229533:FGSG 06818
gene id: 229533:FGSG_06818
uniprot id: I1RRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

229533:FGSG 04275
gene id: 229533:FGSG_04275
uniprot id: I1RK81
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

229533:FGSG 10905
gene id: 229533:FGSG_10905
uniprot id: V6RTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

229533:FGSG 05550
gene id: 229533:FGSG_05550
uniprot id: I1RNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

229533:FGSG 01342
gene id: 229533:FGSG_01342
uniprot id: I1RCM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
messages: Mitochondrion inner membrane

229533:FGSG 01967
gene id: 229533:FGSG_01967
uniprot id: I1RE86
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

229533:FGSG 05247
gene id: 229533:FGSG_05247
uniprot id: A0A1I9FWW1
uniprot id: Q4IC11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.

229533:FGSG 09489
gene id: 229533:FGSG_09489
uniprot id: I1RYN2
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

229533:FGSG 07414
gene id: 229533:FGSG_07414
uniprot id: I1RTB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Mitochondrion

229533:FGSG 06453
gene id: 229533:FGSG_06453
uniprot id: I1RQV3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11464
gene id: 229533:FGSG_11464
uniprot id: I1S3R9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11293
gene id: 229533:FGSG_11293
uniprot id: I1S3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

229533:FGSG 08080
gene id: 229533:FGSG_08080
uniprot id: I1RV20
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Highly expressed under trichothecene-producing conditions.
messages: Nucleus
messages: Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat.

229533:FGSG 03629
gene id: 229533:FGSG_03629
uniprot id: I1RIJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Secreted

229533:FGSG 01673
gene id: 229533:FGSG_01673
uniprot id: I1RDH7
names: Similarity
messages: Belongs to the ustYa family.

229533:FGSG 01121
gene id: 229533:FGSG_01121
uniprot id: I1RC20
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: The SUI1 domain may be involved in RNA binding.

229533:FGSG 11163
gene id: 229533:FGSG_11163
uniprot id: V6RU70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 09381
gene id: 229533:FGSG_09381
uniprot id: V6RPN0
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Endoplasmic reticulum membrane
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Microsome
messages: Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 st…

229533:FGSG 08823
gene id: 229533:FGSG_08823
uniprot id: I1RWY3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09778
gene id: 229533:FGSG_09778
uniprot id: I1RZD9
names: Subcellular Location Annotation
messages: Cell membrane

229533:FGSG 01422
gene id: 229533:FGSG_01422
uniprot id: I1RCU2
names: Similarity
messages: Belongs to the citrate synthase family.

229533:FGSG 03643
gene id: 229533:FGSG_03643
uniprot id: I1RIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 02355
gene id: 229533:FGSG_02355
uniprot id: I1RF88
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

229533:FGSG 07057
gene id: 229533:FGSG_07057
uniprot id: V6RH07
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 11304
gene id: 229533:FGSG_11304
uniprot id: A0A1I9FPA3
uniprot id: I1S3C6
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.
messages: Expression is under the control of transcription factor XYR1 and highly induced by xylan, carboxymethylcellulose (CMC), and hop cell wall.
messages: Inhibited by the wheat xylanase inhibiting protein I (XIP-I).
messages: Secreted

229533:FGSG 08349
gene id: 229533:FGSG_08349
uniprot id: I1RVR1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09842
gene id: 229533:FGSG_09842
uniprot id: I1RZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

229533:FGSG 07407
gene id: 229533:FGSG_07407
uniprot id: I1RTA6
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

229533:FGSG 02121
gene id: 229533:FGSG_02121
uniprot id: I1REM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 01741
gene id: 229533:FGSG_01741
uniprot id: I1RDN1
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 09643
gene id: 229533:FGSG_09643
uniprot id: I1RZ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

229533:FGSG 12737
gene id: 229533:FGSG_12737
uniprot id: I1S7B4
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 07337
gene id: 229533:FGSG_07337
uniprot id: I1RT43
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 03579
gene id: 229533:FGSG_03579
uniprot id: I1RIE7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00586
gene id: 229533:FGSG_00586
uniprot id: I1RAQ2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10885
gene id: 229533:FGSG_10885
uniprot id: I1S299
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

229533:FGSG 00838
gene id: 229533:FGSG_00838
uniprot id: I1RBC4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

229533:FGSG 05805
gene id: 229533:FGSG_05805
uniprot id: I1RP53
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
messages: By cyanide.
messages: Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.
messages: Oligomer of dimers, forming left-handed helical fibers.

229533:FGSG 03145
gene id: 229533:FGSG_03145
uniprot id: I1RHA0
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 01789
gene id: 229533:FGSG_01789
uniprot id: I1RDS4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06204
gene id: 229533:FGSG_06204
uniprot id: V6RCZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

229533:FGSG 03285
gene id: 229533:FGSG_03285
uniprot id: I1RHM5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 03957
gene id: 229533:FGSG_03957
uniprot id: I1RJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05190
gene id: 229533:FGSG_05190
uniprot id: I1RMK0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02381
gene id: 229533:FGSG_02381
uniprot id: I1RFB2
names: Similarity
messages: Belongs to the peptidase S1B family.

229533:FGSG 09005
gene id: 229533:FGSG_09005
uniprot id: I1RXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 00843
gene id: 229533:FGSG_00843
uniprot id: I1RBC7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

229533:FGSG 10604
gene id: 229533:FGSG_10604
uniprot id: I1S1J9
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 11139
gene id: 229533:FGSG_11139
uniprot id: I1S2Y1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05229
gene id: 229533:FGSG_05229
uniprot id: I1RMN6
names: Similarity
messages: Belongs to the bystin family.

229533:FGSG 04944
gene id: 229533:FGSG_04944
uniprot id: I1RLX4
names: Similarity
messages: Belongs to the MAD1 family.

229533:FGSG 03002
gene id: 229533:FGSG_03002
uniprot id: I1RGX1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 11824
gene id: 229533:FGSG_11824
uniprot id: I1S4Q6
names: Similarity
messages: Belongs to the peptidase S9C family.

229533:FGSG 04817
gene id: 229533:FGSG_04817
uniprot id: I1RLL2
names: Similarity
messages: Belongs to the peptidase S28 family.

229533:FGSG 10531
gene id: 229533:FGSG_10531
uniprot id: I1S1D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

229533:FGSG 06572
gene id: 229533:FGSG_06572
uniprot id: I1RR60
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 09471
gene id: 229533:FGSG_09471
uniprot id: I1RYL5
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

229533:FGSG 10918
gene id: 229533:FGSG_10918
uniprot id: I1S2C9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03114
gene id: 229533:FGSG_03114
uniprot id: I1RH70
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

229533:FGSG 08426
gene id: 229533:FGSG_08426
uniprot id: I1RVX9
names: Subcellular Location Annotation
messages: Mitochondrion

229533:FGSG 09021
gene id: 229533:FGSG_09021
uniprot id: I1RXF5
names: Similarity
messages: Belongs to the synaptobrevin family.

229533:FGSG 09367
gene id: 229533:FGSG_09367
uniprot id: I1RYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01014
gene id: 229533:FGSG_01014
uniprot id: I1RBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

229533:FGSG 01946
gene id: 229533:FGSG_01946
uniprot id: I1RE69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 04109
gene id: 229533:FGSG_04109
uniprot id: I1RJS7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01614
gene id: 229533:FGSG_01614
uniprot id: I1RDC0
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

229533:FGSG 06857
gene id: 229533:FGSG_06857
uniprot id: I1RRW0
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Impairs hyphal growth, conidiation, conidial germination, and sexual reproduction (PubMed:30603875). Leads to a defect in pathogenicity and production of the mycotoxin deoxynivalenol (DON) (PubMed:30603875). Displays lipid droplet accumulation (PubMed:30603875). Shows reduced tolerance towards oxidative stress (PubMed:30603875). Leads to down-regulation of protein expression levels related to protein biosynthesis, fatty acid metabolism, cell wall synthesis, and oxidation-reduction reactions (PubMed:30603875).
messages: Ubiquitin-conjugating enzyme E2 that is essential for peroxisome biogenesis and plays a key role in development, pathogenicity, and cell wall integrity (PubMed:30603875). Required for long and very long-chain fatty acid utilization and is involved in lipid droplet accumulation and the elimination of reactive oxygen species (PubMed:30603875). Controls the expression of proteins involved in protein biosynthesis, fatty acid metabolism, cell wall synthesis, oxidation-reduction reactions, as well as of the enzymes involved in the biosynthesis of the mycotoxin deoxynivalenol (DON), including TRI5, TRI6, and TRI10 (PubMed:30603875).

229533:FGSG 01873
gene id: 229533:FGSG_01873
uniprot id: V6QY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 04915
gene id: 229533:FGSG_04915
uniprot id: I1RLU6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

229533:FGSG 01758
gene id: 229533:FGSG_01758
uniprot id: I1RDP5
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

229533:FGSG 07555
gene id: 229533:FGSG_07555
uniprot id: I1RTP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane
messages: Probable lipid hydrolase.

229533:FGSG 08230
gene id: 229533:FGSG_08230
uniprot id: I1RVF6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04738
gene id: 229533:FGSG_04738
uniprot id: I1RLE2
names: Similarity
messages: Belongs to the neutral ceramidase family.

229533:FGSG 01172
gene id: 229533:FGSG_01172
uniprot id: I1RC69
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10712
gene id: 229533:FGSG_10712
uniprot id: I1S1U2
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 05612
gene id: 229533:FGSG_05612
uniprot id: I1RNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 01177
gene id: 229533:FGSG_01177
uniprot id: I1RC74
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

229533:FGSG 10949
gene id: 229533:FGSG_10949
uniprot id: Q4HVQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

229533:FGSG 06019
gene id: 229533:FGSG_06019
uniprot id: I1RPP3
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

229533:FGSG 07454
gene id: 229533:FGSG_07454
uniprot id: I1RTF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 04927
gene id: 229533:FGSG_04927
uniprot id: I1RLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

229533:FGSG 07103
gene id: 229533:FGSG_07103
uniprot id: I1RSI2
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.

229533:FGSG 09786
gene id: 229533:FGSG_09786
uniprot id: I1RZE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

229533:FGSG 10914
gene id: 229533:FGSG_10914
uniprot id: I1S2C5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02851
gene id: 229533:FGSG_02851
uniprot id: I1RGI4
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 04654
gene id: 229533:FGSG_04654
uniprot id: I1RL71
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 02315
gene id: 229533:FGSG_02315
uniprot id: I1RF49
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Does not affect conidiation but results in reduction of cell surface hydrophobicity.
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase. NRPS4 has the following architecture: A-T-E-C-A-T-C-A-T-E-C-A-T-C-A-T-E-C-T-Ct.
messages: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the fusahexin, a cyclic hydrophobic hexapeptide with the amino acid sequence cyclo-(D-Ala-L-Leu-D-allo-Thr-L-Pro-D-Leu-L-Leu) that plays an important role in cell surface hydrophobicity (PubMed:22862913, PubMed:34292732). Fusahexin might also play a role in virulence, sensitivity to osmotic stress and oxidative stress (PubMed:34292732). NRPS4 is the only enzyme within the cluster and its 5 catalytic modules are sufficient to produce fusahexin (PubMed:34292732). The modules 1 to 4 incorporate respectively D-alanine, L-leucine, D-allo-threonine, and L-proline, which is supported by the presence of epimerase domains in modules 1 and 3, which incorporate D-amino acids (PubMed:34292732). The terminal module is responsible for incorporation of the two adjacent leucine units, where the epimerase domain is only used to convert the first unit to D-leucine (PubMed:34292732). The terminal condensation domain (Ct) is involved in cyclization with D-alanine and thereby releasing of fusahexin (PubMed:34292732).

229533:FGSG 03887
gene id: 229533:FGSG_03887
uniprot id: I1RJ79
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07584
gene id: 229533:FGSG_07584
uniprot id: I1RTR9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00659
gene id: 229533:FGSG_00659
uniprot id: I1RAW6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 06127
gene id: 229533:FGSG_06127
uniprot id: I1RPZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 08427
gene id: 229533:FGSG_08427
uniprot id: I1RVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

229533:FGSG 04126
gene id: 229533:FGSG_04126
uniprot id: I1RJU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

229533:FGSG 12042
gene id: 229533:FGSG_12042
uniprot id: I1S5C4
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

229533:FGSG 01374
gene id: 229533:FGSG_01374
uniprot id: I1RCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

229533:FGSG 11922
gene id: 229533:FGSG_11922
uniprot id: I1S504
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

229533:FGSG 10708
gene id: 229533:FGSG_10708
uniprot id: I1S1T8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 10533
gene id: 229533:FGSG_10533
uniprot id: I1S1D3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07683
gene id: 229533:FGSG_07683
uniprot id: V6RJ29
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 00543
gene id: 229533:FGSG_00543
uniprot id: I1RAL2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

229533:FGSG 13489
gene id: 229533:FGSG_13489
uniprot id: I1S9F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.

229533:FGSG 00941
gene id: 229533:FGSG_00941
uniprot id: I1RBL4
names: Similarity
messages: Belongs to the cyclin family.

229533:FGSG 02160
gene id: 229533:FGSG_02160
uniprot id: V6R0W1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 10203
gene id: 229533:FGSG_10203
uniprot id: I1S0H5
names: Similarity
messages: Belongs to the oxoprolinase family.

229533:FGSG 02998
gene id: 229533:FGSG_02998
uniprot id: I1RGW7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10952
gene id: 229533:FGSG_10952
uniprot id: I1S2F9
names: Similarity
messages: Belongs to the RutC family.

229533:FGSG 06657
gene id: 229533:FGSG_06657
uniprot id: I1RRD8
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 04481
gene id: 229533:FGSG_04481
uniprot id: I1RKR5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

229533:FGSG 11467
gene id: 229533:FGSG_11467
uniprot id: I1S3S1
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.
messages: Belongs to the glycosyltransferase 77 family.

229533:FGSG 10174
gene id: 229533:FGSG_10174
uniprot id: I1S0F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 05315
gene id: 229533:FGSG_05315
uniprot id: I1RMW3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 06918
gene id: 229533:FGSG_06918
uniprot id: I1RS14
names: Function
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.

229533:FGSG 12840
gene id: 229533:FGSG_12840
uniprot id: I1S7L7
names: Similarity
messages: Belongs to the taxilin family.

229533:FGSG 02321
gene id: 229533:FGSG_02321
uniprot id: I1RF55
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).
messages: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: Impairs the production of aurofusarin and leads to the accumulation of a light yellow pigment (PubMed:16879655).
messages: Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).
messages: Secreted
messages: extracellular space

229533:FGSG 10815
gene id: 229533:FGSG_10815
uniprot id: I1S232
names: Similarity
messages: Belongs to the APC10 family.

229533:FGSG 06743
gene id: 229533:FGSG_06743
uniprot id: I1RRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

229533:FGSG 10116
gene id: 229533:FGSG_10116
uniprot id: I1S097
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 01932
gene id: 229533:FGSG_01932
uniprot id: I1RE58
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

229533:FGSG 00554
gene id: 229533:FGSG_00554
uniprot id: I1RAM2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

229533:FGSG 10181
gene id: 229533:FGSG_10181
uniprot id: I1S0F6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

229533:FGSG 03356
gene id: 229533:FGSG_03356
uniprot id: I1RHU1
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 09339
gene id: 229533:FGSG_09339
uniprot id: I1RY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEF2 family.
messages: Nucleus

229533:FGSG 08077
gene id: 229533:FGSG_08077
uniprot id: I1RV17
names: Function
names: Induction
names: Similarity
messages: Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.
messages: Highly expressed under trichothecene-producing conditions.
messages: NADH:flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).

229533:FGSG 02406
gene id: 229533:FGSG_02406
uniprot id: I1RFD3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02392
gene id: 229533:FGSG_02392
uniprot id: V6R0R8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 10167
gene id: 229533:FGSG_10167
uniprot id: I1S0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

229533:FGSG 09772
gene id: 229533:FGSG_09772
uniprot id: I1RZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

229533:FGSG 08351
gene id: 229533:FGSG_08351
uniprot id: V6RM02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

229533:FGSG 07948
gene id: 229533:FGSG_07948
uniprot id: I1RUP8
names: Similarity
messages: Belongs to the MOG1 family.

229533:FGSG 05079
gene id: 229533:FGSG_05079
uniprot id: I1RM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

229533:FGSG 08888
gene id: 229533:FGSG_08888
uniprot id: I1RX39
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

229533:FGSG 00752
gene id: 229533:FGSG_00752
uniprot id: I1RB47
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04038
gene id: 229533:FGSG_04038
uniprot id: I1RJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

229533:FGSG 07542
gene id: 229533:FGSG_07542
uniprot id: I1RTN1
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

229533:FGSG 09397
gene id: 229533:FGSG_09397
uniprot id: A0A1I9FHG1
uniprot id: Q4I061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Monomer.

229533:FGSG 03979
gene id: 229533:FGSG_03979
uniprot id: I1RJG2
names: Function
names: Subunit
messages: Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
messages: Interacts with lipid droplet proteins.

229533:FGSG 09543
gene id: 229533:FGSG_09543
uniprot id: I1RYT4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02474
gene id: 229533:FGSG_02474
uniprot id: I1RFJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 07078
gene id: 229533:FGSG_07078
uniprot id: I1RSG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

229533:FGSG 06120
gene id: 229533:FGSG_06120
uniprot id: I1RPY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 04402
gene id: 229533:FGSG_04402
uniprot id: I1RKJ5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.

229533:FGSG 00370
gene id: 229533:FGSG_00370
uniprot id: I1RA46
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08887
gene id: 229533:FGSG_08887
uniprot id: I1RX38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

229533:FGSG 02146
gene id: 229533:FGSG_02146
uniprot id: I1REQ1
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

229533:FGSG 11316
gene id: 229533:FGSG_11316
uniprot id: I1S3D8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 04396
gene id: 229533:FGSG_04396
uniprot id: I1RKJ0
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

229533:FGSG 01691
gene id: 229533:FGSG_01691
uniprot id: I1RDJ1
names: Similarity
messages: Belongs to the EME1/MMS4 family.

229533:FGSG 02527
gene id: 229533:FGSG_02527
uniprot id: I1RFP4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09583
gene id: 229533:FGSG_09583
uniprot id: I1RYX2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12814
gene id: 229533:FGSG_12814
uniprot id: I1S7J1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 06087
gene id: 229533:FGSG_06087
uniprot id: I1RPV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 01892
gene id: 229533:FGSG_01892
uniprot id: V6QYC5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 09140
gene id: 229533:FGSG_09140
uniprot id: I1RXR5
names: Similarity
messages: Belongs to the amidase family.

229533:FGSG 07946
gene id: 229533:FGSG_07946
uniprot id: I1RUP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

229533:FGSG 12134
gene id: 229533:FGSG_12134
uniprot id: I1S5L3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06613
gene id: 229533:FGSG_06613
uniprot id: I1RR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 01254
gene id: 229533:FGSG_01254
uniprot id: I1RCE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

229533:FGSG 07137
gene id: 229533:FGSG_07137
uniprot id: I1RSL4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06279
gene id: 229533:FGSG_06279
uniprot id: I1RQD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

229533:FGSG 06789
gene id: 229533:FGSG_06789
uniprot id: I1RRQ4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05432
gene id: 229533:FGSG_05432
uniprot id: I1RN66
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

229533:FGSG 00852
gene id: 229533:FGSG_00852
uniprot id: I1RBD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

229533:FGSG 11147
gene id: 229533:FGSG_11147
uniprot id: I1S2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05425
gene id: 229533:FGSG_05425
uniprot id: I1RN61
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

229533:FGSG 04298
gene id: 229533:FGSG_04298
uniprot id: A0A1I9FG29
uniprot id: Q4IER0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.

229533:FGSG 01388
gene id: 229533:FGSG_01388
uniprot id: I1RCR2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 08208
gene id: 229533:FGSG_08208
uniprot id: I1RVD8
names: Disruption Phenotype
names: Domain
names: Function
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).
messages: Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (CMeT) domain responsible for the incorporation of methyl groups; an enoylreductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.
messages: impairs the production of fusaristatin A.

229533:FGSG 12974
gene id: 229533:FGSG_12974
uniprot id: I1S7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

229533:FGSG 03069
gene id: 229533:FGSG_03069
uniprot id: I1RH30
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 00152
gene id: 229533:FGSG_00152
uniprot id: I1R9K7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07554
gene id: 229533:FGSG_07554
uniprot id: I1RTP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

229533:FGSG 04827
gene id: 229533:FGSG_04827
uniprot id: I1RLM1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08510
gene id: 229533:FGSG_08510
uniprot id: I1RW55
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 05824
gene id: 229533:FGSG_05824
uniprot id: I1RP70
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 09696
gene id: 229533:FGSG_09696
uniprot id: I1RZ70
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 10655
gene id: 229533:FGSG_10655
uniprot id: I1S1P4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11552
gene id: 229533:FGSG_11552
uniprot id: I1S400
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07120
gene id: 229533:FGSG_07120
uniprot id: I1RSJ9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

229533:FGSG 01232
gene id: 229533:FGSG_01232
uniprot id: I1RCC7
names: Similarity
messages: Belongs to the YOS1 family.

229533:FGSG 09366
gene id: 229533:FGSG_09366
uniprot id: I1RYC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

229533:FGSG 02358
gene id: 229533:FGSG_02358
uniprot id: V6QZK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02872
gene id: 229533:FGSG_02872
uniprot id: I1RGK2
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 10866
gene id: 229533:FGSG_10866
uniprot id: I1S280
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

229533:FGSG 00503
gene id: 229533:FGSG_00503
uniprot id: I1RAH3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

229533:FGSG 07074
gene id: 229533:FGSG_07074
uniprot id: I1RSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01816
gene id: 229533:FGSG_01816
uniprot id: I1RDU9
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 12242
gene id: 229533:FGSG_12242
uniprot id: I1S5X1
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 07567
gene id: 229533:FGSG_07567
uniprot id: I1RTQ3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07484
gene id: 229533:FGSG_07484
uniprot id: A0A1I9FH57
uniprot id: Q4I5M4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

229533:FGSG 00874
gene id: 229533:FGSG_00874
uniprot id: A0A1I9EWU4
uniprot id: Q4IPI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Belongs to the actin family. ARP4 subfamily.
messages: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.
messages: Nucleus

229533:FGSG 05853
gene id: 229533:FGSG_05853
uniprot id: I1RP96
names: Similarity
messages: Belongs to the TAF11 family.

229533:FGSG 02212
gene id: 229533:FGSG_02212
uniprot id: I1REV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 00610
gene id: 229533:FGSG_00610
uniprot id: I1RAS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

229533:FGSG 06951
gene id: 229533:FGSG_06951
uniprot id: I1RS43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

229533:FGSG 10301
gene id: 229533:FGSG_10301
uniprot id: I1S0R4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

229533:FGSG 05183
gene id: 229533:FGSG_05183
uniprot id: I1RMJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

229533:FGSG 09181
gene id: 229533:FGSG_09181
uniprot id: I1RXV5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 12548
gene id: 229533:FGSG_12548
uniprot id: I1S6S5
names: Similarity
messages: Belongs to the tannase family.

229533:FGSG 09616
gene id: 229533:FGSG_09616
uniprot id: I1RYZ9
names: Similarity
messages: Belongs to the cullin family.

229533:FGSG 10423
gene id: 229533:FGSG_10423
uniprot id: I1S129
names: Similarity
messages: Belongs to the RUS1 family.

229533:FGSG 09565
gene id: 229533:FGSG_09565
uniprot id: I1RYV4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08309
gene id: 229533:FGSG_08309
uniprot id: I1RVM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 11125
gene id: 229533:FGSG_11125
uniprot id: I1S2W9
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 05557
gene id: 229533:FGSG_05557
uniprot id: I1RNH7
names: Similarity
messages: Belongs to the COG1 family.

229533:FGSG 03628
gene id: 229533:FGSG_03628
uniprot id: I1RIJ1
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

229533:FGSG 05293
gene id: 229533:FGSG_05293
uniprot id: I1RMU3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06451
gene id: 229533:FGSG_06451
uniprot id: I1RQV1
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

229533:FGSG 03767
gene id: 229533:FGSG_03767
uniprot id: I1RIX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.

229533:FGSG 05604
gene id: 229533:FGSG_05604
uniprot id: I1RNM1
names: Similarity
messages: Belongs to the SPT2 family.

229533:FGSG 03417
gene id: 229533:FGSG_03417
uniprot id: I1RHZ8
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 07634
gene id: 229533:FGSG_07634
uniprot id: I1RTW6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09078
gene id: 229533:FGSG_09078
uniprot id: I1RXK7
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 08452
gene id: 229533:FGSG_08452
uniprot id: I1RW00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

229533:FGSG 07291
gene id: 229533:FGSG_07291
uniprot id: I1RT03
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

229533:FGSG 02597
gene id: 229533:FGSG_02597
uniprot id: I1RFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 11974
gene id: 229533:FGSG_11974
uniprot id: I1S556
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 00297
gene id: 229533:FGSG_00297
uniprot id: I1R9Y1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

229533:FGSG 09818
gene id: 229533:FGSG_09818
uniprot id: I1RZH6
names: Similarity
messages: Belongs to the TYW1 family.

229533:FGSG 02461
gene id: 229533:FGSG_02461
uniprot id: I1RFI4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

229533:FGSG 03264
gene id: 229533:FGSG_03264
uniprot id: I1RHK6
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08987
gene id: 229533:FGSG_08987
uniprot id: I1RXC3
names: Function
names: Similarity
messages: Belongs to the LCL2 family.
messages: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.

229533:FGSG 05483
gene id: 229533:FGSG_05483
uniprot id: I1RNB5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 13176
gene id: 229533:FGSG_13176
uniprot id: I1S8J8
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 02252
gene id: 229533:FGSG_02252
uniprot id: I1REZ3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04858
gene id: 229533:FGSG_04858
uniprot id: I1RLP4
names: Subcellular Location Annotation
messages: Cell surface

229533:FGSG 13196
gene id: 229533:FGSG_13196
uniprot id: I1S8L8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 10330
gene id: 229533:FGSG_10330
uniprot id: I1S0U1
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 04723
gene id: 229533:FGSG_04723
uniprot id: I1RLD0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05369
gene id: 229533:FGSG_05369
uniprot id: I1RN11
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

229533:FGSG 02382
gene id: 229533:FGSG_02382
uniprot id: I1RFB3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07333
gene id: 229533:FGSG_07333
uniprot id: I1RT40
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

229533:FGSG 08908
gene id: 229533:FGSG_08908
uniprot id: I1RX58
names: Similarity
messages: Belongs to the peptidase C59 family.

229533:FGSG 04676
gene id: 229533:FGSG_04676
uniprot id: I1RL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01537
gene id: 229533:FGSG_01537
uniprot id: I1RD48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOZART1 family.
messages: Part of the gamma-tubulin complex.
messages: Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).
messages: spindle pole body

229533:FGSG 13398
gene id: 229533:FGSG_13398
uniprot id: I1S968
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

229533:FGSG 03003
gene id: 229533:FGSG_03003
uniprot id: I1RGX2
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 05998
gene id: 229533:FGSG_05998
uniprot id: I1RPM3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01051
gene id: 229533:FGSG_01051
uniprot id: I1RBW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

229533:FGSG 03413
gene id: 229533:FGSG_03413
uniprot id: I1RHZ4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 05286
gene id: 229533:FGSG_05286
uniprot id: V6R9X9
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

229533:FGSG 04111
gene id: 229533:FGSG_04111
uniprot id: I1RJS9
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 09483
gene id: 229533:FGSG_09483
uniprot id: I1RYM6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 00430
gene id: 229533:FGSG_00430
uniprot id: I1RAA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

229533:FGSG 00051
gene id: 229533:FGSG_00051
uniprot id: I1R9B8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

229533:FGSG 04451
gene id: 229533:FGSG_04451
uniprot id: A0A1I9FG04
uniprot id: Q4IEA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with missfolded ER lumenal proteins.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

229533:FGSG 02010
gene id: 229533:FGSG_02010
uniprot id: I1REC3
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

229533:FGSG 00148
gene id: 229533:FGSG_00148
uniprot id: I1R9K4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01484
gene id: 229533:FGSG_01484
uniprot id: I1RCZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05589
gene id: 229533:FGSG_05589
uniprot id: I1RNK6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00565
gene id: 229533:FGSG_00565
uniprot id: I1RAN3
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

229533:FGSG 12641
gene id: 229533:FGSG_12641
uniprot id: I1S718
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09383
gene id: 229533:FGSG_09383
uniprot id: I1RYD7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

229533:FGSG 09332
gene id: 229533:FGSG_09332
uniprot id: I1RY92
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

229533:FGSG 02070
gene id: 229533:FGSG_02070
uniprot id: I1REI1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09423
gene id: 229533:FGSG_09423
uniprot id: I1RYH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

229533:FGSG 10796
gene id: 229533:FGSG_10796
uniprot id: I1S215
names: Similarity
messages: Belongs to the MIT1/WOR1 family.

229533:FGSG 04113
gene id: 229533:FGSG_04113
uniprot id: I1RJT1
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

229533:FGSG 04663
gene id: 229533:FGSG_04663
uniprot id: I1RL80
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 00863
gene id: 229533:FGSG_00863
uniprot id: I1RBE6
names: Similarity
messages: Belongs to the peptidase M16 family.

229533:FGSG 06841
gene id: 229533:FGSG_06841
uniprot id: I1RRU9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.

229533:FGSG 04329
gene id: 229533:FGSG_04329
uniprot id: I1RKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

229533:FGSG 00435
gene id: 229533:FGSG_00435
uniprot id: I1RAA8
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 09446
gene id: 229533:FGSG_09446
uniprot id: I1RYJ2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

229533:FGSG 06788
gene id: 229533:FGSG_06788
uniprot id: I1RRQ3
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 04149
gene id: 229533:FGSG_04149
uniprot id: I1RJW6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

229533:FGSG 08861
gene id: 229533:FGSG_08861
uniprot id: I1RX18
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01746
gene id: 229533:FGSG_01746
uniprot id: I1RDN6
names: Similarity
messages: Belongs to the isochorismatase family.

229533:FGSG 10114
gene id: 229533:FGSG_10114
uniprot id: I1S095
names: Subcellular Location Annotation
messages: Cell membrane

229533:FGSG 09794
gene id: 229533:FGSG_09794
uniprot id: I1RZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex ASK1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 07909
gene id: 229533:FGSG_07909
uniprot id: I1RUL1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06020
gene id: 229533:FGSG_06020
uniprot id: I1RPP4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

229533:FGSG 10295
gene id: 229533:FGSG_10295
uniprot id: I1S0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 10036
gene id: 229533:FGSG_10036
uniprot id: I1S024
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

229533:FGSG 11556
gene id: 229533:FGSG_11556
uniprot id: I1S404
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00596
gene id: 229533:FGSG_00596
uniprot id: I1RAR1
names: Similarity
messages: Belongs to the asparaginase 1 family.

229533:FGSG 08805
gene id: 229533:FGSG_08805
uniprot id: I1RWW9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06094
gene id: 229533:FGSG_06094
uniprot id: I1RPW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.

229533:FGSG 00914
gene id: 229533:FGSG_00914
uniprot id: I1RBI9
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

229533:FGSG 13385
gene id: 229533:FGSG_13385
uniprot id: I1S955
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

229533:FGSG 11084
gene id: 229533:FGSG_11084
uniprot id: I1S2T1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10804
gene id: 229533:FGSG_10804
uniprot id: I1S223
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 06566
gene id: 229533:FGSG_06566
uniprot id: V6RE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02544
gene id: 229533:FGSG_02544
uniprot id: I1RFQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 08083
gene id: 229533:FGSG_08083
uniprot id: I1RV23
names: Function
names: Induction
names: Similarity
messages: Belongs to the group II decarboxylase family.
messages: Glutamate decarboxylase-like protein; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).
messages: Highly expressed under trichothecene-producing conditions.

229533:FGSG 05857
gene id: 229533:FGSG_05857
uniprot id: I1RPA0
names: Similarity
messages: Belongs to the SF3A3 family.

229533:FGSG 03078
gene id: 229533:FGSG_03078
uniprot id: I1RH37
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

229533:FGSG 10044
gene id: 229533:FGSG_10044
uniprot id: I1S030
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01329
gene id: 229533:FGSG_01329
uniprot id: I1RCL0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

229533:FGSG 05108
gene id: 229533:FGSG_05108
uniprot id: I1RMC0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 08977
gene id: 229533:FGSG_08977
uniprot id: I1RXB6
names: Similarity
messages: Belongs to the HMBS family.

229533:FGSG 00397
gene id: 229533:FGSG_00397
uniprot id: I1RA72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

229533:FGSG 00636
gene id: 229533:FGSG_00636
uniprot id: A0A1I9EW15
uniprot id: Q4IQ72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm

229533:FGSG 01295
gene id: 229533:FGSG_01295
uniprot id: I1RCI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 11275
gene id: 229533:FGSG_11275
uniprot id: I1S3A0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09665
gene id: 229533:FGSG_09665
uniprot id: I1RZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

229533:FGSG 10760
gene id: 229533:FGSG_10760
uniprot id: I1S1Y2
names: Similarity
messages: Belongs to the Tango6 family.

229533:FGSG 04636
gene id: 229533:FGSG_04636
uniprot id: V6R3D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 12250
gene id: 229533:FGSG_12250
uniprot id: I1S5X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

229533:FGSG 08081
gene id: 229533:FGSG_08081
uniprot id: I1RV21
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Highly expressed under trichothecene-producing conditions.

229533:FGSG 06308
gene id: 229533:FGSG_06308
uniprot id: I1RQG6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

229533:FGSG 04404
gene id: 229533:FGSG_04404
uniprot id: I1RKJ6
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 01743
gene id: 229533:FGSG_01743
uniprot id: I1RDN3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

229533:FGSG 02528
gene id: 229533:FGSG_02528
uniprot id: A0A1I9F214
uniprot id: Q4IJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 00945
gene id: 229533:FGSG_00945
uniprot id: Q4IPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).

229533:FGSG 08690
gene id: 229533:FGSG_08690
uniprot id: I1RWL5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08814
gene id: 229533:FGSG_08814
uniprot id: I1RWX8
names: Similarity
messages: Belongs to the SF3B5 family.

229533:FGSG 06001
gene id: 229533:FGSG_06001
uniprot id: I1RPM6
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

229533:FGSG 02649
gene id: 229533:FGSG_02649
uniprot id: I1RG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

229533:FGSG 01533
gene id: 229533:FGSG_01533
uniprot id: I1RD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in transport through the plasma membrane.

229533:FGSG 10245
gene id: 229533:FGSG_10245
uniprot id: I1S0L3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

229533:FGSG 09587
gene id: 229533:FGSG_09587
uniprot id: I1RYX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: Vacuole membrane

229533:FGSG 07668
gene id: 229533:FGSG_07668
uniprot id: I1RTZ8
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 05045
gene id: 229533:FGSG_05045
uniprot id: I1RM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

229533:FGSG 07299
gene id: 229533:FGSG_07299
uniprot id: I1RT09
names: Similarity
messages: Belongs to the GcvT family. CAF17 subfamily.

229533:FGSG 05935
gene id: 229533:FGSG_05935
uniprot id: I1RPG6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 11884
gene id: 229533:FGSG_11884
uniprot id: I1S4W6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

229533:FGSG 01299
gene id: 229533:FGSG_01299
uniprot id: I1RCI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

229533:FGSG 06463
gene id: 229533:FGSG_06463
uniprot id: I1RQW2
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

229533:FGSG 08619
gene id: 229533:FGSG_08619
uniprot id: I1RWF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

229533:FGSG 04117
gene id: 229533:FGSG_04117
uniprot id: I1RJT5
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

229533:FGSG 04483
gene id: 229533:FGSG_04483
uniprot id: I1RKR7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

229533:FGSG 00536
gene id: 229533:FGSG_00536
uniprot id: I1RAK5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02379
gene id: 229533:FGSG_02379
uniprot id: I1RFB0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 09456
gene id: 229533:FGSG_09456
uniprot id: I1RYK0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

229533:FGSG 11262
gene id: 229533:FGSG_11262
uniprot id: I1S389
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05352
gene id: 229533:FGSG_05352
uniprot id: I1RMZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 08566
gene id: 229533:FGSG_08566
uniprot id: I1RWA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 00080
gene id: 229533:FGSG_00080
uniprot id: V6QSM8
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

229533:FGSG 06784
gene id: 229533:FGSG_06784
uniprot id: V6RG22
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

229533:FGSG 02917
gene id: 229533:FGSG_02917
uniprot id: I1RGP4
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 01929
gene id: 229533:FGSG_01929
uniprot id: I1RE55
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

229533:FGSG 04774
gene id: 229533:FGSG_04774
uniprot id: I1RLH4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05015
gene id: 229533:FGSG_05015
uniprot id: I1RM37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrial mRNA stabilization factor.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial mRNA stabilization factor.

229533:FGSG 01122
gene id: 229533:FGSG_01122
uniprot id: I1RC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

229533:FGSG 07237
gene id: 229533:FGSG_07237
uniprot id: I1RSV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

229533:FGSG 00877
gene id: 229533:FGSG_00877
uniprot id: A0A1I9EX09
uniprot id: Q4IPI1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 04673
gene id: 229533:FGSG_04673
uniprot id: I1RL87
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 05050
gene id: 229533:FGSG_05050
uniprot id: I1RM68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 02077
gene id: 229533:FGSG_02077
uniprot id: I1REI8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: Cell membrane
messages: Cell septum
messages: Cytoplasm
messages: Decreases virulence in maize stalks (PubMed:36577386). No sensitivity to Congo Red (cell wall disrupting agent) or sodium dodecyl sulfate (SDS) (membrane disrupting agent), and in vitro cell population growth appears normal (PubMed:36577386).
messages: Expressed during the spore stage, in conidia, during germination, and weakly in hyphae (at protein level).
messages: Interacts with Z.mays LRR5; the interaction is direct (PubMed:36577386). Interacts (via CFEM domain) with Z.mays WAK17 isoform 2; the interaction is direct (PubMed:36577386).
messages: Secreted
messages: Suppresses host programmed cell death during infection by binding to Z.mays WAK17 isoform 2 and Z.mays LRR5, to prevent activation of Z.mays WAK17 isoform 1 and the downstream hypersensitive response.
messages: The CFEM domain mediates interactions with host proteins.
messages: cell wall

229533:FGSG 02702
gene id: 229533:FGSG_02702
uniprot id: I1RG53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

229533:FGSG 07476
gene id: 229533:FGSG_07476
uniprot id: I1RTH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

229533:FGSG 06408
gene id: 229533:FGSG_06408
uniprot id: I1RQR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 02596
gene id: 229533:FGSG_02596
uniprot id: I1RFV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.

229533:FGSG 07701
gene id: 229533:FGSG_07701
uniprot id: I1RU25
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11396
gene id: 229533:FGSG_11396
uniprot id: I1S3K8
names: Function
names: Similarity
messages: Amidase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).
messages: Belongs to the asparagine synthetase family.

229533:FGSG 01761
gene id: 229533:FGSG_01761
uniprot id: I1RDP7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

229533:FGSG 03649
gene id: 229533:FGSG_03649
uniprot id: I1RIL1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08895
gene id: 229533:FGSG_08895
uniprot id: V6RIV9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

229533:FGSG 07017
gene id: 229533:FGSG_07017
uniprot id: I1RSA3
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

229533:FGSG 03769
gene id: 229533:FGSG_03769
uniprot id: I1RIX2
names: Similarity
messages: Belongs to the peptidase S10 family.

229533:FGSG 10960
gene id: 229533:FGSG_10960
uniprot id: I1S2G6
names: Subunit
messages: Homotetramer.

229533:FGSG 03035
gene id: 229533:FGSG_03035
uniprot id: I1RH01
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

229533:FGSG 01896
gene id: 229533:FGSG_01896
uniprot id: I1RE23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

229533:FGSG 13099
gene id: 229533:FGSG_13099
uniprot id: I1S8C1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

229533:FGSG 12937
gene id: 229533:FGSG_12937
uniprot id: I1S7W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

229533:FGSG 07787
gene id: 229533:FGSG_07787
uniprot id: I1RUA2
names: Similarity
messages: Belongs to the Necrosis inducing protein (NPP1) family.

229533:FGSG 10837
gene id: 229533:FGSG_10837
uniprot id: I1S253
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

229533:FGSG 06895
gene id: 229533:FGSG_06895
uniprot id: I1RRZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.
messages: Vacuole

229533:FGSG 02040
gene id: 229533:FGSG_02040
uniprot id: I1REF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

229533:FGSG 01364
gene id: 229533:FGSG_01364
uniprot id: I1RCP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

229533:FGSG 08182
gene id: 229533:FGSG_08182
uniprot id: I1RVB5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02605
gene id: 229533:FGSG_02605
uniprot id: I1RFW4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 08480
gene id: 229533:FGSG_08480
uniprot id: I1RW27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 01900
gene id: 229533:FGSG_01900
uniprot id: I1RE27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

229533:FGSG 03231
gene id: 229533:FGSG_03231
uniprot id: I1RHH8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11684
gene id: 229533:FGSG_11684
uniprot id: I1S4B7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 04910
gene id: 229533:FGSG_04910
uniprot id: I1RLU1
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

229533:FGSG 01062
gene id: 229533:FGSG_01062
uniprot id: I1RBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

229533:FGSG 09775
gene id: 229533:FGSG_09775
uniprot id: I1RZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00219
gene id: 229533:FGSG_00219
uniprot id: I1R9R4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11044
gene id: 229533:FGSG_11044
uniprot id: I1S2P4
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 04930
gene id: 229533:FGSG_04930
uniprot id: I1RLW0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 05611
gene id: 229533:FGSG_05611
uniprot id: I1RNM8
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 00639
gene id: 229533:FGSG_00639
uniprot id: A0A1I9EW63
uniprot id: Q5I2J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

229533:FGSG 07856
gene id: 229533:FGSG_07856
uniprot id: I1RUG3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

229533:FGSG 04589
gene id: 229533:FGSG_04589
uniprot id: I1RL12
names: Biotechnology
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: S-adenosyl-L-methionine-dependent methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 10794
gene id: 229533:FGSG_10794
uniprot id: I1S213
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04598
gene id: 229533:FGSG_04598
uniprot id: I1RL20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 00175
gene id: 229533:FGSG_00175
uniprot id: I1R9M6
names: Similarity
messages: Belongs to the citrate synthase family.

229533:FGSG 09294
gene id: 229533:FGSG_09294
uniprot id: I1RY57
names: Similarity
messages: Belongs to the band 7/mec-2 family.

229533:FGSG 00979
gene id: 229533:FGSG_00979
uniprot id: V6R2Z2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 08581
gene id: 229533:FGSG_08581
uniprot id: V6RKK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

229533:FGSG 01024
gene id: 229533:FGSG_01024
uniprot id: Q4IP34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 03966
gene id: 229533:FGSG_03966
uniprot id: I1RJF0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07169
gene id: 229533:FGSG_07169
uniprot id: I1RSP1
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

229533:FGSG 08045
gene id: 229533:FGSG_08045
uniprot id: I1RUY6
names: Similarity
messages: Belongs to the LacAB/RpiB family.

229533:FGSG 10685
gene id: 229533:FGSG_10685
uniprot id: I1S1R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01675
gene id: 229533:FGSG_01675
uniprot id: I1RDH9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11205
gene id: 229533:FGSG_11205
uniprot id: I1S341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-platanin family.
messages: Secreted

229533:FGSG 06350
gene id: 229533:FGSG_06350
uniprot id: I1RQK5
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

229533:FGSG 01010
gene id: 229533:FGSG_01010
uniprot id: V6QVD5
names: Similarity
messages: Belongs to the HTATSF1 family.

229533:FGSG 00654
gene id: 229533:FGSG_00654
uniprot id: V6QUG0
names: Similarity
messages: Belongs to the NifU family.

229533:FGSG 10212
gene id: 229533:FGSG_10212
uniprot id: I1S0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-platanin family.
messages: Secreted

229533:FGSG 03928
gene id: 229533:FGSG_03928
uniprot id: I1RJB7
names: Similarity
messages: Belongs to the PrpF family.

229533:FGSG 10858
gene id: 229533:FGSG_10858
uniprot id: I1S272
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.

229533:FGSG 05371
gene id: 229533:FGSG_05371
uniprot id: I1RN13
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
messages: Binds 1 FAD per subunit.
messages: Expression is induced under iron starvation conditions (PubMed:20507510).
messages: Homotetramer.
messages: Impairs the production of siderophores and leads to slow growth under low iron conditions (PubMed:20507510). Does not affect the ability to infect single, inoculated spikelets, but prevents the spreading from spikelet-to-spikelet through the rachises of wheat spikes (PubMed:20507510).
messages: L-ornithine N(5)-monooxygenase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:20507510). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).

229533:FGSG 10769
gene id: 229533:FGSG_10769
uniprot id: V6RVG3
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 05011
gene id: 229533:FGSG_05011
uniprot id: I1RM34
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04188
gene id: 229533:FGSG_04188
uniprot id: I1RK04
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06858
gene id: 229533:FGSG_06858
uniprot id: I1RRW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

229533:FGSG 09262
gene id: 229533:FGSG_09262
uniprot id: A0A1I9FJC0
uniprot id: Q4I0J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

229533:FGSG 04596
gene id: 229533:FGSG_04596
uniprot id: I1RL18
names: Biotechnology
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 01281
gene id: 229533:FGSG_01281
uniprot id: I1RCG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

229533:FGSG 00898
gene id: 229533:FGSG_00898
uniprot id: I1RBH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

229533:FGSG 02565
gene id: 229533:FGSG_02565
uniprot id: I1RFS7
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

229533:FGSG 06675
gene id: 229533:FGSG_06675
uniprot id: I1RRF5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

229533:FGSG 09111
gene id: 229533:FGSG_09111
uniprot id: I1RXN7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09185
gene id: 229533:FGSG_09185
uniprot id: I1RXV9
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

229533:FGSG 06386
gene id: 229533:FGSG_06386
uniprot id: Q4I8S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: May be involved in protection from oxidative damage.
messages: Mitochondrion

229533:FGSG 11040
gene id: 229533:FGSG_11040
uniprot id: I1S2P0
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 00695
gene id: 229533:FGSG_00695
uniprot id: I1RAZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 12379
gene id: 229533:FGSG_12379
uniprot id: I1S6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

229533:FGSG 05227
gene id: 229533:FGSG_05227
uniprot id: I1RMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00697
gene id: 229533:FGSG_00697
uniprot id: I1RB00
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.

229533:FGSG 06072
gene id: 229533:FGSG_06072
uniprot id: I1RPU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

229533:FGSG 09254
gene id: 229533:FGSG_09254
uniprot id: I1RY25
names: Similarity
messages: Belongs to the patched family.

229533:FGSG 03170
gene id: 229533:FGSG_03170
uniprot id: I1RHC4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 00052
gene id: 229533:FGSG_00052
uniprot id: I1R9B9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05211
gene id: 229533:FGSG_05211
uniprot id: I1RML9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01665
gene id: 229533:FGSG_01665
uniprot id: I1RDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

229533:FGSG 02921
gene id: 229533:FGSG_02921
uniprot id: I1RGP8
names: Function
names: Similarity
messages: Belongs to the choline monooxygenase family.
messages: Catalyzes the first step of the osmoprotectant glycine betaine synthesis.

229533:FGSG 00334
gene id: 229533:FGSG_00334
uniprot id: I1RA17
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00278
gene id: 229533:FGSG_00278
uniprot id: I1R9W4
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.

229533:FGSG 00915
gene id: 229533:FGSG_00915
uniprot id: I1RBJ0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02009
gene id: 229533:FGSG_02009
uniprot id: I1REC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 07832
gene id: 229533:FGSG_07832
uniprot id: I1RUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

229533:FGSG 07674
gene id: 229533:FGSG_07674
uniprot id: I1RU04
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06920
gene id: 229533:FGSG_06920
uniprot id: I1RS16
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

229533:FGSG 09572
gene id: 229533:FGSG_09572
uniprot id: I1RYW1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

229533:FGSG 08579
gene id: 229533:FGSG_08579
uniprot id: I1RWB6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07468
gene id: 229533:FGSG_07468
uniprot id: I1RTG4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 03532
gene id: 229533:FGSG_03532
uniprot id: I1RIA2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

229533:FGSG 11182
gene id: 229533:FGSG_11182
uniprot id: I1S321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01099
gene id: 229533:FGSG_01099
uniprot id: I1RC00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

229533:FGSG 02677
gene id: 229533:FGSG_02677
uniprot id: I1RG28
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

229533:FGSG 02869
gene id: 229533:FGSG_02869
uniprot id: I1RGJ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03695
gene id: 229533:FGSG_03695
uniprot id: I1RIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 02026
gene id: 229533:FGSG_02026
uniprot id: A0A1I9F0S0
uniprot id: Q4IL82
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

229533:FGSG 06442
gene id: 229533:FGSG_06442
uniprot id: I1RQU2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06922
gene id: 229533:FGSG_06922
uniprot id: V6RGI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

229533:FGSG 04433
gene id: 229533:FGSG_04433
uniprot id: I1RKM2
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 06553
gene id: 229533:FGSG_06553
uniprot id: I1RR44
names: Similarity
messages: Belongs to the XFP family.

229533:FGSG 07669
gene id: 229533:FGSG_07669
uniprot id: I1RTZ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06330
gene id: 229533:FGSG_06330
uniprot id: I1RQI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

229533:FGSG 08023
gene id: 229533:FGSG_08023
uniprot id: I1RUW5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 02014
gene id: 229533:FGSG_02014
uniprot id: I1REC7
names: Similarity
messages: Belongs to the heat shock protein 90 family.

229533:FGSG 05217
gene id: 229533:FGSG_05217
uniprot id: I1RMM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

229533:FGSG 00774
gene id: 229533:FGSG_00774
uniprot id: I1RB67
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00871
gene id: 229533:FGSG_00871
uniprot id: I1RBF3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

229533:FGSG 05144
gene id: 229533:FGSG_05144
uniprot id: I1RMF5
names: Similarity
messages: Belongs to the DeSI family.

229533:FGSG 12909
gene id: 229533:FGSG_12909
uniprot id: I1S7T4
names: Similarity
messages: Belongs to the UPF0235 family.

229533:FGSG 03118
gene id: 229533:FGSG_03118
uniprot id: I1RH73
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04637
gene id: 229533:FGSG_04637
uniprot id: I1RL54
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01256
gene id: 229533:FGSG_01256
uniprot id: I1RCE6
names: Similarity
messages: Belongs to the UPP synthase family.

229533:FGSG 10418
gene id: 229533:FGSG_10418
uniprot id: I1S124
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.
messages: Belongs to the glycosyltransferase 77 family.

229533:FGSG 08479
gene id: 229533:FGSG_08479
uniprot id: I1RW26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

229533:FGSG 07304
gene id: 229533:FGSG_07304
uniprot id: I1RT14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 04854
gene id: 229533:FGSG_04854
uniprot id: I1RLP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

229533:FGSG 03834
gene id: 229533:FGSG_03834
uniprot id: I1RJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

229533:FGSG 13527
gene id: 229533:FGSG_13527
uniprot id: I1S9J6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01417
gene id: 229533:FGSG_01417
uniprot id: I1RCT7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

229533:FGSG 00338
gene id: 229533:FGSG_00338
uniprot id: I1RA21
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05152
gene id: 229533:FGSG_05152
uniprot id: I1RMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cytoskeleton

229533:FGSG 10634
gene id: 229533:FGSG_10634
uniprot id: I1S1M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 06221
gene id: 229533:FGSG_06221
uniprot id: I1RQ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 03673
gene id: 229533:FGSG_03673
uniprot id: I1RIN3
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 02287
gene id: 229533:FGSG_02287
uniprot id: I1RF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

229533:FGSG 13189
gene id: 229533:FGSG_13189
uniprot id: I1S8L1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 10921
gene id: 229533:FGSG_10921
uniprot id: I1S2D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00023
gene id: 229533:FGSG_00023
uniprot id: I1R994
names: Similarity
messages: Belongs to the germin family.

229533:FGSG 06544
gene id: 229533:FGSG_06544
uniprot id: V6RDH3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

229533:FGSG 00500
gene id: 229533:FGSG_00500
uniprot id: I1RAH1
names: Similarity
messages: Belongs to the hexokinase family.

229533:FGSG 10740
gene id: 229533:FGSG_10740
uniprot id: I1S1W5
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG8 family.
messages: Conjugation to phosphatidylethanolamine (PE) leads to homodimerization (By similarity). Interacts with ATG1, ATG3, ATG4, ATG7 and ATG12 (By similarity).
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: The C-terminal Glu-117 and Ala-118 residues of ATG8 are removed by ATG4 to expose Gly-116 at the C-terminus (By similarity). This Gly-116 forms then a thioester bond with the 'Cys-550' of ATG7 (E1-like activating enzyme) before being transferred to the 'Cys-244' of ATG3 (the specific E2 conjugating enzyme), in order to be finally amidated with phosphatidylethanolamine (By similarity). This lipid modification anchors ATG8 to membranes and can be reversed by ATG4, releasing soluble ATG8 (By similarity).
messages: Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation (By similarity). With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Participates also in membrane fusion events that take place in the early secretory pathway (By similarity). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Moreover not only conjugation, but also subsequent ATG8-PE deconjugation is an important step required to facilitate multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Vacuole membrane
messages: autophagosome membrane
messages: cvt vesicle membrane

229533:FGSG 05931
gene id: 229533:FGSG_05931
uniprot id: I1RPG2
names: Similarity
messages: Belongs to the COG2 family.

229533:FGSG 01791
gene id: 229533:FGSG_01791
uniprot id: I1RDS6
names: Similarity
messages: Belongs to the PrpD family.

229533:FGSG 04072
gene id: 229533:FGSG_04072
uniprot id: I1RJP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

229533:FGSG 00637
gene id: 229533:FGSG_00637
uniprot id: I1RAU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

229533:FGSG 04204
gene id: 229533:FGSG_04204
uniprot id: I1RK17
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 01128
gene id: 229533:FGSG_01128
uniprot id: I1RC27
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

229533:FGSG 09725
gene id: 229533:FGSG_09725
uniprot id: I1RZ95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

229533:FGSG 06150
gene id: 229533:FGSG_06150
uniprot id: I1RQ17
names: Similarity
messages: Belongs to the glutathione peroxidase family.

229533:FGSG 13006
gene id: 229533:FGSG_13006
uniprot id: I1S830
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

229533:FGSG 04289
gene id: 229533:FGSG_04289
uniprot id: V6R3L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

229533:FGSG 09464
gene id: 229533:FGSG_09464
uniprot id: I1RYK8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09722
gene id: 229533:FGSG_09722
uniprot id: I1RZ92
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Isopentenyl-diphosphate delta-isomerase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). IDI1 catalyzes the 1,3-allylic rearrangement of isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

229533:FGSG 01233
gene id: 229533:FGSG_01233
uniprot id: I1RCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 10850
gene id: 229533:FGSG_10850
uniprot id: I1S265
names: Similarity
messages: Belongs to the TCF25 family.

229533:FGSG 09241
gene id: 229533:FGSG_09241
uniprot id: I1RY13
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

229533:FGSG 05952
gene id: 229533:FGSG_05952
uniprot id: I1RPI2
names: Similarity
messages: Belongs to the SGT1 family.

229533:FGSG 04929
gene id: 229533:FGSG_04929
uniprot id: I1RLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

229533:FGSG 09250
gene id: 229533:FGSG_09250
uniprot id: I1RY21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

229533:FGSG 02533
gene id: 229533:FGSG_02533
uniprot id: I1RFP9
names: Similarity
messages: Belongs to the PRP18 family.

229533:FGSG 03537
gene id: 229533:FGSG_03537
uniprot id: A0A1I9FCV5
uniprot id: Q00909
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the trichodiene synthase family.
messages: TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
messages: Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.

229533:FGSG 07285
gene id: 229533:FGSG_07285
uniprot id: I1RSZ7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

229533:FGSG 04828
gene id: 229533:FGSG_04828
uniprot id: I1RLM2
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

229533:FGSG 05707
gene id: 229533:FGSG_05707
uniprot id: I1RNW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02992
gene id: 229533:FGSG_02992
uniprot id: I1RGW1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02281
gene id: 229533:FGSG_02281
uniprot id: I1RF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 05635
gene id: 229533:FGSG_05635
uniprot id: I1RNQ1
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

229533:FGSG 01057
gene id: 229533:FGSG_01057
uniprot id: I1RBW6
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

229533:FGSG 00593
gene id: 229533:FGSG_00593
uniprot id: I1RAQ8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04350
gene id: 229533:FGSG_04350
uniprot id: A0A1I9FFB7
uniprot id: Q4IEK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 01230
gene id: 229533:FGSG_01230
uniprot id: I1RCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09844
gene id: 229533:FGSG_09844
uniprot id: I1RZJ7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

229533:FGSG 07458
gene id: 229533:FGSG_07458
uniprot id: I1RTF5
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

229533:FGSG 07720
gene id: 229533:FGSG_07720
uniprot id: I1RU41
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03605
gene id: 229533:FGSG_03605
uniprot id: I1RIH2
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 02352
gene id: 229533:FGSG_02352
uniprot id: I1RF85
names: Similarity
messages: Belongs to the citrate synthase family.

229533:FGSG 10936
gene id: 229533:FGSG_10936
uniprot id: Q4HVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GNT1 family.
messages: Golgi apparatus membrane
messages: N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
messages: Vacuole membrane

229533:FGSG 06927
gene id: 229533:FGSG_06927
uniprot id: I1RS20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

229533:FGSG 11709
gene id: 229533:FGSG_11709
uniprot id: I1S4E2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00587
gene id: 229533:FGSG_00587
uniprot id: A0A1I9EVV7
uniprot id: Q4IQC1
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.

229533:FGSG 08551
gene id: 229533:FGSG_08551
uniprot id: I1RW90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

229533:FGSG 13347
gene id: 229533:FGSG_13347
uniprot id: I1S917
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02370
gene id: 229533:FGSG_02370
uniprot id: I1RFA1
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 01606
gene id: 229533:FGSG_01606
uniprot id: I1RDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

229533:FGSG 08967
gene id: 229533:FGSG_08967
uniprot id: I1RXA7
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.
messages: Belongs to the glycosyltransferase 77 family.

229533:FGSG 05221
gene id: 229533:FGSG_05221
uniprot id: I1RMM8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

229533:FGSG 05159
gene id: 229533:FGSG_05159
uniprot id: I1RMG9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multicopper oxidase family.
messages: Cell membrane
messages: Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent iron acquisition process (PubMed:20507510). Required to oxidize Fe(2+) and release it from the transporter (By similarity). Seems not to be involved in virulence (PubMed:20507510).
messages: Expression is up-regulated during iron starvation (PubMed:20507510).
messages: Produces wild-type amounts of siderophores and growth at the same rate as the wild-type under iron limitation, but accumulates high levels of free intracellular iron (PubMed:20507510). Does not affect the virulence (PubMed:20507510).

229533:FGSG 10358
gene id: 229533:FGSG_10358
uniprot id: Q4HXF0
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.

229533:FGSG 00026
gene id: 229533:FGSG_00026
uniprot id: I1R997
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01354
gene id: 229533:FGSG_01354
uniprot id: I1RCN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

229533:FGSG 01553
gene id: 229533:FGSG_01553
uniprot id: I1RD64
names: Similarity
messages: Belongs to the RRP12 family.

229533:FGSG 08381
gene id: 229533:FGSG_08381
uniprot id: A0A1I9F8H5
uniprot id: Q4I327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

229533:FGSG 12647
gene id: 229533:FGSG_12647
uniprot id: I1S724
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

229533:FGSG 00745
gene id: 229533:FGSG_00745
uniprot id: I1RB40
names: Similarity
messages: Belongs to the NPR2 family.

229533:FGSG 06016
gene id: 229533:FGSG_06016
uniprot id: I1RPP0
names: Similarity
messages: Belongs to the DOCK family.

229533:FGSG 09659
gene id: 229533:FGSG_09659
uniprot id: I1RZ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.

229533:FGSG 09040
gene id: 229533:FGSG_09040
uniprot id: I1RXH1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

229533:FGSG 00328
gene id: 229533:FGSG_00328
uniprot id: I1RA11
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

229533:FGSG 09354
gene id: 229533:FGSG_09354
uniprot id: I1RYB2
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 10290
gene id: 229533:FGSG_10290
uniprot id: I1S0Q4
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

229533:FGSG 02771
gene id: 229533:FGSG_02771
uniprot id: I1RGB3
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 05658
gene id: 229533:FGSG_05658
uniprot id: I1RNS1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

229533:FGSG 07067
gene id: 229533:FGSG_07067
uniprot id: I1RSE9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03457
gene id: 229533:FGSG_03457
uniprot id: I1RI35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 01270
gene id: 229533:FGSG_01270
uniprot id: I1RCF6
names: Similarity
messages: Belongs to the OPA3 family.

229533:FGSG 05193
gene id: 229533:FGSG_05193
uniprot id: I1RMK3
names: Similarity
messages: Belongs to the MAK16 family.

229533:FGSG 05058
gene id: 229533:FGSG_05058
uniprot id: I1RM75
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

229533:FGSG 11111
gene id: 229533:FGSG_11111
uniprot id: I1S2V7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13993
gene id: 229533:FGSG_13993
uniprot id: I1SAW2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07631
gene id: 229533:FGSG_07631
uniprot id: I1RTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03744
gene id: 229533:FGSG_03744
uniprot id: I1RIU9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05149
gene id: 229533:FGSG_05149
uniprot id: I1RMF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

229533:FGSG 00076
gene id: 229533:FGSG_00076
uniprot id: I1R9E1
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 06703
gene id: 229533:FGSG_06703
uniprot id: I1RRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

229533:FGSG 08206
gene id: 229533:FGSG_08206
uniprot id: I1RVD6
names: Function
messages: Part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).

229533:FGSG 08860
gene id: 229533:FGSG_08860
uniprot id: I1RX17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

229533:FGSG 06645
gene id: 229533:FGSG_06645
uniprot id: I1RRC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane
messages: Probable lipid hydrolase.

229533:FGSG 09359
gene id: 229533:FGSG_09359
uniprot id: A0A1I9FQS6
uniprot id: Q4I099
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit (By similarity).
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
messages: Mitochondrion inner membrane

229533:FGSG 02359
gene id: 229533:FGSG_02359
uniprot id: I1RF90
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 03683
gene id: 229533:FGSG_03683
uniprot id: I1RIP1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03946
gene id: 229533:FGSG_03946
uniprot id: I1RJD3
names: Similarity
messages: Belongs to the thioredoxin family.

229533:FGSG 02030
gene id: 229533:FGSG_02030
uniprot id: I1REE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

229533:FGSG 02383
gene id: 229533:FGSG_02383
uniprot id: I1RFB4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

229533:FGSG 04412
gene id: 229533:FGSG_04412
uniprot id: I1RKK2
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

229533:FGSG 05431
gene id: 229533:FGSG_05431
uniprot id: V6RBN2
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

229533:FGSG 09373
gene id: 229533:FGSG_09373
uniprot id: I1RYC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

229533:FGSG 07083
gene id: 229533:FGSG_07083
uniprot id: A0A1I9FLN4
uniprot id: Q4I6S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: Prevacuolar compartment membrane
messages: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
messages: Vacuole membrane
messages: multivesicular body membrane

229533:FGSG 05525
gene id: 229533:FGSG_05525
uniprot id: I1RNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

229533:FGSG 01104
gene id: 229533:FGSG_01104
uniprot id: I1RC05
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

229533:FGSG 03917
gene id: 229533:FGSG_03917
uniprot id: I1RJA8
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

229533:FGSG 02778
gene id: 229533:FGSG_02778
uniprot id: I1RGB9
names: Subcellular Location Annotation
messages: Chromosome

229533:FGSG 00505
gene id: 229533:FGSG_00505
uniprot id: I1RAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

229533:FGSG 05114
gene id: 229533:FGSG_05114
uniprot id: I1RMC5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

229533:FGSG 07266
gene id: 229533:FGSG_07266
uniprot id: I1RSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Mitochondrion matrix

229533:FGSG 05106
gene id: 229533:FGSG_05106
uniprot id: I1RMB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

229533:FGSG 04643
gene id: 229533:FGSG_04643
uniprot id: I1RL60
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06313
gene id: 229533:FGSG_06313
uniprot id: I1RQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

229533:FGSG 01194
gene id: 229533:FGSG_01194
uniprot id: I1RC91
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

229533:FGSG 02918
gene id: 229533:FGSG_02918
uniprot id: I1RGP5
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 10246
gene id: 229533:FGSG_10246
uniprot id: I1S0L4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

229533:FGSG 07173
gene id: 229533:FGSG_07173
uniprot id: I1RSP5
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 09039
gene id: 229533:FGSG_09039
uniprot id: I1RXH0
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 08385
gene id: 229533:FGSG_08385
uniprot id: V6RLW2
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

229533:FGSG 03908
gene id: 229533:FGSG_03908
uniprot id: V6R454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 00549
gene id: 229533:FGSG_00549
uniprot id: I1RAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG33 family.
messages: Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Mitochondrion membrane

229533:FGSG 03984
gene id: 229533:FGSG_03984
uniprot id: I1RJG4
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

229533:FGSG 01572
gene id: 229533:FGSG_01572
uniprot id: I1RD80
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 02368
gene id: 229533:FGSG_02368
uniprot id: I1RF99
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10739
gene id: 229533:FGSG_10739
uniprot id: V6RVJ3
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

229533:FGSG 06688
gene id: 229533:FGSG_06688
uniprot id: I1RRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

229533:FGSG 00385
gene id: 229533:FGSG_00385
uniprot id: Q4IQX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
messages: Nucleus
messages: Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.

229533:FGSG 09738
gene id: 229533:FGSG_09738
uniprot id: I1RZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

229533:FGSG 04879
gene id: 229533:FGSG_04879
uniprot id: I1RLR4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07967
gene id: 229533:FGSG_07967
uniprot id: I1RUR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

229533:FGSG 04232
gene id: 229533:FGSG_04232
uniprot id: I1RK44
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

229533:FGSG 02207
gene id: 229533:FGSG_02207
uniprot id: I1REV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

229533:FGSG 09852
gene id: 229533:FGSG_09852
uniprot id: I1RZK5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

229533:FGSG 10189
gene id: 229533:FGSG_10189
uniprot id: I1S0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

229533:FGSG 09619
gene id: 229533:FGSG_09619
uniprot id: I1RZ02
names: Similarity
messages: Belongs to the PPP phosphatase family.

229533:FGSG 05181
gene id: 229533:FGSG_05181
uniprot id: I1RMJ1
names: Similarity
messages: Belongs to the SEC6 family.

229533:FGSG 02418
gene id: 229533:FGSG_02418
uniprot id: I1RFE4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00303
gene id: 229533:FGSG_00303
uniprot id: I1R9Y7
names: Similarity
messages: Belongs to the SKP1 family.

229533:FGSG 04305
gene id: 229533:FGSG_04305
uniprot id: I1RKA8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06798
gene id: 229533:FGSG_06798
uniprot id: Q4I7L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.

229533:FGSG 00924
gene id: 229533:FGSG_00924
uniprot id: I1RBJ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10989
gene id: 229533:FGSG_10989
uniprot id: I1S2J3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.
messages: Short chain dehydrogenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).

229533:FGSG 09562
gene id: 229533:FGSG_09562
uniprot id: I1RYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

229533:FGSG 05414
gene id: 229533:FGSG_05414
uniprot id: I1RN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 05001
gene id: 229533:FGSG_05001
uniprot id: V6R8C4
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

229533:FGSG 06012
gene id: 229533:FGSG_06012
uniprot id: I1RPN6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05392
gene id: 229533:FGSG_05392
uniprot id: I1RN30
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 04504
gene id: 229533:FGSG_04504
uniprot id: I1RKT7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

229533:FGSG 01107
gene id: 229533:FGSG_01107
uniprot id: I1RC08
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

229533:FGSG 09601
gene id: 229533:FGSG_09601
uniprot id: A0A1I9FNL8
uniprot id: Q4HZK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Cytoplasm
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

229533:FGSG 02518
gene id: 229533:FGSG_02518
uniprot id: Q4IJU0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
messages: Nucleus

229533:FGSG 06164
gene id: 229533:FGSG_06164
uniprot id: I1RQ30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

229533:FGSG 07666
gene id: 229533:FGSG_07666
uniprot id: I1RTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03922
gene id: 229533:FGSG_03922
uniprot id: V6R5Q6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 10067
gene id: 229533:FGSG_10067
uniprot id: I1S051
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

229533:FGSG 07247
gene id: 229533:FGSG_07247
uniprot id: I1RSW2
names: Similarity
messages: Belongs to the NSRP1 family.

229533:FGSG 04282
gene id: 229533:FGSG_04282
uniprot id: I1RK88
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

229533:FGSG 11150
gene id: 229533:FGSG_11150
uniprot id: V6RU86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 11486
gene id: 229533:FGSG_11486
uniprot id: I1S3T8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07048
gene id: 229533:FGSG_07048
uniprot id: V6RMW6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

229533:FGSG 05210
gene id: 229533:FGSG_05210
uniprot id: I1RML8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

229533:FGSG 00683
gene id: 229533:FGSG_00683
uniprot id: I1RAY7
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 06255
gene id: 229533:FGSG_06255
uniprot id: I1RQB4
names: Similarity
messages: Belongs to the UFD1 family.

229533:FGSG 06886
gene id: 229533:FGSG_06886
uniprot id: I1RRY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

229533:FGSG 05331
gene id: 229533:FGSG_05331
uniprot id: I1RMX7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06931
gene id: 229533:FGSG_06931
uniprot id: I1RS24
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

229533:FGSG 07456
gene id: 229533:FGSG_07456
uniprot id: I1RTF3
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

229533:FGSG 09631
gene id: 229533:FGSG_09631
uniprot id: I1RZ13
names: Function
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.

229533:FGSG 00780
gene id: 229533:FGSG_00780
uniprot id: I1RB73
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

229533:FGSG 02470
gene id: 229533:FGSG_02470
uniprot id: I1RFJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

229533:FGSG 00588
gene id: 229533:FGSG_00588
uniprot id: I1RAQ3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBT5 family.
messages: Cell membrane
messages: Cell septum
messages: Cytoplasm
messages: Decreases virulence in maize stalks (PubMed:36577386). No sensitivity to Congo Red (cell wall disrupting agent) or sodium dodecyl sulfate (SDS) (membrane disrupting agent), and in vitro cell population growth appears normal (PubMed:36577386).
messages: Expressed during the spore stage, in conidia, during germination, and weakly in hyphae (at protein level).
messages: Interacts with Z.mays LRR5; the interaction is direct (PubMed:36577386). Interacts with Z.mays WAK17 isoform 2; the interaction is direct (PubMed:36577386).
messages: Secreted
messages: Suppresses host programmed cell death during infection by binding to Z.mays WAK17 isoform 2 and Z.mays LRR5, to prevent activation of Z.mays WAK17 isoform 1 and the downstream hypersensitive response.
messages: The CFEM domain mediates interactions with host proteins.

229533:FGSG 02686
gene id: 229533:FGSG_02686
uniprot id: I1RG37
names: Similarity
messages: Belongs to the RNase T2 family.

229533:FGSG 05506
gene id: 229533:FGSG_05506
uniprot id: I1RND3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05423
gene id: 229533:FGSG_05423
uniprot id: I1RN59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWF11 family.
messages: Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
messages: Nucleus

229533:FGSG 05385
gene id: 229533:FGSG_05385
uniprot id: I1RN24
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02071
gene id: 229533:FGSG_02071
uniprot id: I1REI2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

229533:FGSG 02117
gene id: 229533:FGSG_02117
uniprot id: I1REM5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 01969
gene id: 229533:FGSG_01969
uniprot id: I1RE88
names: Similarity
messages: Belongs to the lysophospholipase family.

229533:FGSG 05926
gene id: 229533:FGSG_05926
uniprot id: I1RPF7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07363
gene id: 229533:FGSG_07363
uniprot id: A0A1I9FJP6
uniprot id: Q4I5Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

229533:FGSG 06874
gene id: 229533:FGSG_06874
uniprot id: I1RRX4
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

229533:FGSG 10965
gene id: 229533:FGSG_10965
uniprot id: I1S2H1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

229533:FGSG 01334
gene id: 229533:FGSG_01334
uniprot id: I1RCL5
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

229533:FGSG 09178
gene id: 229533:FGSG_09178
uniprot id: I1RXV2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00539
gene id: 229533:FGSG_00539
uniprot id: I1RAK8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Major facilitator transporter involved in extracellular siderophore uptake (PubMed:20507510). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875).
messages: Not expressed during infection (PubMed:20507510).

229533:FGSG 02520
gene id: 229533:FGSG_02520
uniprot id: I1RFN9
names: Similarity
messages: Belongs to the VPS72/YL1 family.

229533:FGSG 02043
gene id: 229533:FGSG_02043
uniprot id: I1REF5
names: Function
messages: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.

229533:FGSG 10729
gene id: 229533:FGSG_10729
uniprot id: I1S1V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

229533:FGSG 02454
gene id: 229533:FGSG_02454
uniprot id: I1RFH9
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

229533:FGSG 07429
gene id: 229533:FGSG_07429
uniprot id: I1RTC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

229533:FGSG 06755
gene id: 229533:FGSG_06755
uniprot id: I1RRM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

229533:FGSG 07379
gene id: 229533:FGSG_07379
uniprot id: I1RT80
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

229533:FGSG 01580
gene id: 229533:FGSG_01580
uniprot id: I1RD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

229533:FGSG 10138
gene id: 229533:FGSG_10138
uniprot id: A0A1I9F3N8
uniprot id: Q4HY20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 03217
gene id: 229533:FGSG_03217
uniprot id: I1RHG4
names: Similarity
messages: Belongs to the tannase family.

229533:FGSG 05578
gene id: 229533:FGSG_05578
uniprot id: I1RNJ5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11697
gene id: 229533:FGSG_11697
uniprot id: I1S4D0
names: Similarity
messages: Belongs to the glutamine synthetase family.

229533:FGSG 06996
gene id: 229533:FGSG_06996
uniprot id: I1RS83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

229533:FGSG 10068
gene id: 229533:FGSG_10068
uniprot id: A0A1I9F3I5
uniprot id: Q4HY90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

229533:FGSG 05370
gene id: 229533:FGSG_05370
uniprot id: I1RN12
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04092
gene id: 229533:FGSG_04092
uniprot id: I1RJR2
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Results in high sensitivity to triadimefon and antifungal azoles such as propiconazole (PubMed:20955812, PubMed:23442154). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).
messages: Endoplasmic reticulum membrane
messages: Expression is induced by azole antifungals such as prochloraz, tebuconazole or epoxiconazole (PubMed:23442154). Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Together with cyp51B and cyp51C, encodes the sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:20955812, PubMed:23442154). CYP51A encodes the sterol 14-alpha-demethylase induced on ergosterol depletion and is responsible for the intrinsic variation in azole sensitivity (PubMed:20955812, PubMed:23442154). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (Probable). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4'-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).

229533:FGSG 02478
gene id: 229533:FGSG_02478
uniprot id: I1RFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 00715
gene id: 229533:FGSG_00715
uniprot id: I1RB14
names: Function
names: Similarity
messages: Belongs to the FYV10 family.
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.

229533:FGSG 01509
gene id: 229533:FGSG_01509
uniprot id: I1RD22
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

229533:FGSG 11977
gene id: 229533:FGSG_11977
uniprot id: I1S559
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

229533:FGSG 03102
gene id: 229533:FGSG_03102
uniprot id: I1RH59
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09863
gene id: 229533:FGSG_09863
uniprot id: I1RZL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

229533:FGSG 00433
gene id: 229533:FGSG_00433
uniprot id: I1RAA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Membrane
messages: Preautophagosomal structure membrane

229533:FGSG 03272
gene id: 229533:FGSG_03272
uniprot id: I1RHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 09980
gene id: 229533:FGSG_09980
uniprot id: I1RZX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

229533:FGSG 05230
gene id: 229533:FGSG_05230
uniprot id: I1RMN7
names: Similarity
messages: Belongs to the HGH1 family.

229533:FGSG 12188
gene id: 229533:FGSG_12188
uniprot id: I1S5R7
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

229533:FGSG 07018
gene id: 229533:FGSG_07018
uniprot id: I1RSA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

229533:FGSG 04580
gene id: 229533:FGSG_04580
uniprot id: I1RL06
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: ABC transporter involved in zearalenone production (PubMed:21833740).
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Cell membrane
messages: Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:21833740).
messages: Results in the loss of zearalenone production (PubMed:21833740).
messages: Vacuole membrane

229533:FGSG 03812
gene id: 229533:FGSG_03812
uniprot id: I1RJ13
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 10481
gene id: 229533:FGSG_10481
uniprot id: I1S182
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 03992
gene id: 229533:FGSG_03992
uniprot id: V6R5I4
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

229533:FGSG 12164
gene id: 229533:FGSG_12164
uniprot id: A0A1I9F2Z5
uniprot id: I1S5P3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIT1/WOR1 family.
messages: Global transcriptional regulator of pathogenicity. Regulates many genes during growth in putrescine medium and during infection. Involved in the developmental processes of conidium formation and sexual reproduction and modulates a morphological change that accompanies mycotoxin production.
messages: Nucleus
messages: Results in greatly reduced pathogenicity and loss of trichothecene toxin accumulation in infected wheat plants. Exhibits normal vegetative growth but shows defects in asexual and sexual spore development.

229533:FGSG 11292
gene id: 229533:FGSG_11292
uniprot id: I1S3B6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

229533:FGSG 05574
gene id: 229533:FGSG_05574
uniprot id: V6RHZ8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09612
gene id: 229533:FGSG_09612
uniprot id: A0A1I9FNK6
uniprot id: P0C431
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.
messages: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).
messages: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.
messages: Nucleus
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

229533:FGSG 10129
gene id: 229533:FGSG_10129
uniprot id: A0A1I9F4M0
uniprot id: I1S0A8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1/PHD1/stuA family.
messages: Does not develop perithecia and sexual ascospores, and lacks conidiophores and phialides (PubMed:20879840). Greatly reduces pathogenicity on wheat heads and production of secondary metabolites such as deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Leads to up-regulation of cell-cycle genes which promoters are highly enriched in StuA-response elements (StRE) (PubMed:20879840).
messages: Nucleus
messages: Transcription factor that regulates asexual reproduction (PubMed:20879840). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:20879840). Controls the expression of the gene clusters involved in the production of deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Regulates the expression of genes involved in chitin and glucan metabolism (PubMed:20879840). Controls also catalase activity and cell surface hydrophobicity (PubMed:20879840). Plays an important role in pathogenicity (PubMed:20879840).

229533:FGSG 06268
gene id: 229533:FGSG_06268
uniprot id: I1RQC7
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

229533:FGSG 05565
gene id: 229533:FGSG_05565
uniprot id: I1RNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

229533:FGSG 08489
gene id: 229533:FGSG_08489
uniprot id: I1RW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09773
gene id: 229533:FGSG_09773
uniprot id: A0A1I9FNI4
uniprot id: Q4HZ35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 08338
gene id: 229533:FGSG_08338
uniprot id: V6RKN5
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

229533:FGSG 07258
gene id: 229533:FGSG_07258
uniprot id: I1RSX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 02523
gene id: 229533:FGSG_02523
uniprot id: A0A1I9F2T0
uniprot id: Q4IJT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization (By similarity).
messages: cytoskeleton

229533:FGSG 04758
gene id: 229533:FGSG_04758
uniprot id: I1RLG1
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 06178
gene id: 229533:FGSG_06178
uniprot id: I1RQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 02746
gene id: 229533:FGSG_02746
uniprot id: I1RG90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

229533:FGSG 00799
gene id: 229533:FGSG_00799
uniprot id: I1RB89
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Forms a heterodimer with SLX1.
messages: Nucleus
messages: Phosphorylated in response to DNA damage.
messages: Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

229533:FGSG 09484
gene id: 229533:FGSG_09484
uniprot id: I1RYM7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00600
gene id: 229533:FGSG_00600
uniprot id: I1RAR5
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 00404
gene id: 229533:FGSG_00404
uniprot id: I1RA77
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03448
gene id: 229533:FGSG_03448
uniprot id: I1RI27
names: Function
names: Similarity
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.

229533:FGSG 06320
gene id: 229533:FGSG_06320
uniprot id: I1RQH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex.
messages: trans-Golgi network

229533:FGSG 08960
gene id: 229533:FGSG_08960
uniprot id: I1RXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

229533:FGSG 01631
gene id: 229533:FGSG_01631
uniprot id: I1RDD5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02325
gene id: 229533:FGSG_02325
uniprot id: I1RF59
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the tpcK family.
messages: Dehydratase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).
messages: Impairs autofusarin biosynthesis and leads to the accumulation of the intermediate YWA1 (PubMed:21296881).

229533:FGSG 01198
gene id: 229533:FGSG_01198
uniprot id: I1RC95
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 04410
gene id: 229533:FGSG_04410
uniprot id: I1RKK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

229533:FGSG 11526
gene id: 229533:FGSG_11526
uniprot id: I1S3X6
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

229533:FGSG 00828
gene id: 229533:FGSG_00828
uniprot id: I1RBB6
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

229533:FGSG 00139
gene id: 229533:FGSG_00139
uniprot id: V6QU99
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 02637
gene id: 229533:FGSG_02637
uniprot id: A0A1I9F2S9
uniprot id: Q4IJH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 10507
gene id: 229533:FGSG_10507
uniprot id: I1S1A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

229533:FGSG 07457
gene id: 229533:FGSG_07457
uniprot id: I1RTF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

229533:FGSG 05335
gene id: 229533:FGSG_05335
uniprot id: I1RMY1
names: Similarity
messages: Belongs to the threonine aldolase family.

229533:FGSG 06436
gene id: 229533:FGSG_06436
uniprot id: I1RQT6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05862
gene id: 229533:FGSG_05862
uniprot id: I1RPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

229533:FGSG 12031
gene id: 229533:FGSG_12031
uniprot id: I1S5B3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

229533:FGSG 03248
gene id: 229533:FGSG_03248
uniprot id: I1RHJ1
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA) (Probable). FgAQP2 has NPA/NLA motifs which is in accordance with the fungal aquaporins (NPx and NxA) (Probable).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Leads to no variable phenotypes.
messages: Membrane
messages: Probable water/glycerol channel that may have redundant functions with FgAQP4.

229533:FGSG 09928
gene id: 229533:FGSG_09928
uniprot id: I1RZS5
names: Similarity
messages: Belongs to the syntaxin family.

229533:FGSG 08747
gene id: 229533:FGSG_08747
uniprot id: I1RWR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

229533:FGSG 06392
gene id: 229533:FGSG_06392
uniprot id: I1RQP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

229533:FGSG 04120
gene id: 229533:FGSG_04120
uniprot id: I1RJT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

229533:FGSG 07306
gene id: 229533:FGSG_07306
uniprot id: I1RT16
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02563
gene id: 229533:FGSG_02563
uniprot id: I1RFS5
names: Similarity
messages: Belongs to the peptidase M16 family.

229533:FGSG 01323
gene id: 229533:FGSG_01323
uniprot id: I1RCK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

229533:FGSG 03044
gene id: 229533:FGSG_03044
uniprot id: I1RH09
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00183
gene id: 229533:FGSG_00183
uniprot id: I1R9N2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10422
gene id: 229533:FGSG_10422
uniprot id: I1S128
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 12141
gene id: 229533:FGSG_12141
uniprot id: I1S5M0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11976
gene id: 229533:FGSG_11976
uniprot id: I1S558
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

229533:FGSG 03483
gene id: 229533:FGSG_03483
uniprot id: I1RI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 08997
gene id: 229533:FGSG_08997
uniprot id: A0A1I9FKU8
uniprot id: Q4I1B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 04428
gene id: 229533:FGSG_04428
uniprot id: I1RKL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRI1 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 07533
gene id: 229533:FGSG_07533
uniprot id: I1RTM2
names: Similarity
messages: Belongs to the pectinesterase family.

229533:FGSG 09232
gene id: 229533:FGSG_09232
uniprot id: I1RY04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

229533:FGSG 10816
gene id: 229533:FGSG_10816
uniprot id: V6RVB4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Leads to no variable phenotypes.
messages: Membrane
messages: Probable water channel that may have redundant functions with FgAQP3.

229533:FGSG 07528
gene id: 229533:FGSG_07528
uniprot id: I1RTL7
names: Similarity
messages: Belongs to the pyruvate kinase family.

229533:FGSG 03242
gene id: 229533:FGSG_03242
uniprot id: I1RHI7
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.
messages: Belongs to the glycosyltransferase 77 family.

229533:FGSG 01596
gene id: 229533:FGSG_01596
uniprot id: I1RDA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 05579
gene id: 229533:FGSG_05579
uniprot id: I1RNJ6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11454
gene id: 229533:FGSG_11454
uniprot id: I1S3Q9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 05023
gene id: 229533:FGSG_05023
uniprot id: I1RM44
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

229533:FGSG 00058
gene id: 229533:FGSG_00058
uniprot id: I1R9C4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03323
gene id: 229533:FGSG_03323
uniprot id: I1RHR1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04945
gene id: 229533:FGSG_04945
uniprot id: V6RG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

229533:FGSG 10147
gene id: 229533:FGSG_10147
uniprot id: I1S0C5
names: Similarity
messages: Belongs to the Fmt family.

229533:FGSG 12505
gene id: 229533:FGSG_12505
uniprot id: I1S6N2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00646
gene id: 229533:FGSG_00646
uniprot id: I1RAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 05701
gene id: 229533:FGSG_05701
uniprot id: I1RNV9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

229533:FGSG 11562
gene id: 229533:FGSG_11562
uniprot id: I1S410
names: Similarity
messages: Belongs to the tannase family.

229533:FGSG 07423
gene id: 229533:FGSG_07423
uniprot id: I1RTC2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

229533:FGSG 02762
gene id: 229533:FGSG_02762
uniprot id: I1RGA4
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

229533:FGSG 01627
gene id: 229533:FGSG_01627
uniprot id: A0A1I9EZD8
uniprot id: Q4IMD1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated once deposited into chromatin.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (By similarity).
messages: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).

229533:FGSG 11115
gene id: 229533:FGSG_11115
uniprot id: I1S2W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

229533:FGSG 10424
gene id: 229533:FGSG_10424
uniprot id: I1S130
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). MVD1 converts diphosphomevalonate into isopentenyl diphosphate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
messages: Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.
messages: Homodimer.

229533:FGSG 01351
gene id: 229533:FGSG_01351
uniprot id: I1RCN0
names: Similarity
messages: Belongs to the SUN family.

229533:FGSG 06804
gene id: 229533:FGSG_06804
uniprot id: A0A1I9FK29
uniprot id: Q4I7K4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 08844
gene id: 229533:FGSG_08844
uniprot id: I1RX03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 13655
gene id: 229533:FGSG_13655
uniprot id: I1S9X4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 07253
gene id: 229533:FGSG_07253
uniprot id: I1RSW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Lysosome membrane
messages: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.

229533:FGSG 09635
gene id: 229533:FGSG_09635
uniprot id: I1RZ17
names: Similarity
messages: Belongs to the peptidase C13 family.

229533:FGSG 09076
gene id: 229533:FGSG_09076
uniprot id: I1RXK5
names: Similarity
messages: Belongs to the RdRP family.

229533:FGSG 05365
gene id: 229533:FGSG_05365
uniprot id: I1RN08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

229533:FGSG 11812
gene id: 229533:FGSG_11812
uniprot id: I1S4P4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

229533:FGSG 06183
gene id: 229533:FGSG_06183
uniprot id: I1RQ47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix

229533:FGSG 11606
gene id: 229533:FGSG_11606
uniprot id: I1S447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10164
gene id: 229533:FGSG_10164
uniprot id: I1S0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

229533:FGSG 00395
gene id: 229533:FGSG_00395
uniprot id: I1RA70
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

229533:FGSG 05591
gene id: 229533:FGSG_05591
uniprot id: I1RNK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 13641
gene id: 229533:FGSG_13641
uniprot id: I1S9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

229533:FGSG 09849
gene id: 229533:FGSG_09849
uniprot id: I1RZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 10041
gene id: 229533:FGSG_10041
uniprot id: I1S027
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

229533:FGSG 08637
gene id: 229533:FGSG_08637
uniprot id: I1RWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
messages: Nucleus

229533:FGSG 08358
gene id: 229533:FGSG_08358
uniprot id: I1RVR7
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

229533:FGSG 12202
gene id: 229533:FGSG_12202
uniprot id: I1S5T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Mitochondrion
messages: Oligomer.

229533:FGSG 06771
gene id: 229533:FGSG_06771
uniprot id: I1RRN8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07127
gene id: 229533:FGSG_07127
uniprot id: I1RSK5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

229533:FGSG 05984
gene id: 229533:FGSG_05984
uniprot id: I1RPL1
names: Similarity
messages: Belongs to the IMPACT family.

229533:FGSG 06723
gene id: 229533:FGSG_06723
uniprot id: Q4I7T5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
messages: Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.

229533:FGSG 12694
gene id: 229533:FGSG_12694
uniprot id: I1S771
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

229533:FGSG 05889
gene id: 229533:FGSG_05889
uniprot id: I1RPC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01887
gene id: 229533:FGSG_01887
uniprot id: I1RE15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

229533:FGSG 03990
gene id: 229533:FGSG_03990
uniprot id: I1RJH0
names: Function
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.

229533:FGSG 04095
gene id: 229533:FGSG_04095
uniprot id: I1RJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

229533:FGSG 09500
gene id: 229533:FGSG_09500
uniprot id: I1RYP2
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

229533:FGSG 11274
gene id: 229533:FGSG_11274
uniprot id: I1S399
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 11921
gene id: 229533:FGSG_11921
uniprot id: I1S503
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

229533:FGSG 06335
gene id: 229533:FGSG_06335
uniprot id: I1RQJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

229533:FGSG 12711
gene id: 229533:FGSG_12711
uniprot id: I1S788
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.
messages: telomere

229533:FGSG 00268
gene id: 229533:FGSG_00268
uniprot id: I1R9V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 01933
gene id: 229533:FGSG_01933
uniprot id: I1RE59
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 04783
gene id: 229533:FGSG_04783
uniprot id: I1RLI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06379
gene id: 229533:FGSG_06379
uniprot id: I1RQN3
names: Similarity
messages: Belongs to the exportin family.

229533:FGSG 08609
gene id: 229533:FGSG_08609
uniprot id: I1RWE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 02699
gene id: 229533:FGSG_02699
uniprot id: I1RG50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

229533:FGSG 10967
gene id: 229533:FGSG_10967
uniprot id: I1S2H3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

229533:FGSG 08676
gene id: 229533:FGSG_08676
uniprot id: I1RWK3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

229533:FGSG 08481
gene id: 229533:FGSG_08481
uniprot id: I1RW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Chromosome

229533:FGSG 01485
gene id: 229533:FGSG_01485
uniprot id: I1RCZ8
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

229533:FGSG 02482
gene id: 229533:FGSG_02482
uniprot id: I1RFK3
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

229533:FGSG 06517
gene id: 229533:FGSG_06517
uniprot id: I1RR14
names: Similarity
messages: Belongs to the IlvD/Edd family.

229533:FGSG 11413
gene id: 229533:FGSG_11413
uniprot id: I1S3M4
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 04397
gene id: 229533:FGSG_04397
uniprot id: I1RKJ1
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 05184
gene id: 229533:FGSG_05184
uniprot id: I1RMJ4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 07518
gene id: 229533:FGSG_07518
uniprot id: I1RTK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 05195
gene id: 229533:FGSG_05195
uniprot id: I1RMK4
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

229533:FGSG 10840
gene id: 229533:FGSG_10840
uniprot id: I1S256
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

229533:FGSG 01528
gene id: 229533:FGSG_01528
uniprot id: I1RD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 06861
gene id: 229533:FGSG_06861
uniprot id: I1RRW4
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 04055
gene id: 229533:FGSG_04055
uniprot id: I1RJN0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09406
gene id: 229533:FGSG_09406
uniprot id: I1RYF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

229533:FGSG 10037
gene id: 229533:FGSG_10037
uniprot id: A0A1I9F4B7
uniprot id: Q4HYC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus
messages: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).
messages: telomere

229533:FGSG 06359
gene id: 229533:FGSG_06359
uniprot id: I1RQL4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09271
gene id: 229533:FGSG_09271
uniprot id: I1RY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: nuclear pore complex

229533:FGSG 00083
gene id: 229533:FGSG_00083
uniprot id: I1R9E7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13128
gene id: 229533:FGSG_13128
uniprot id: I1S8F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

229533:FGSG 05669
gene id: 229533:FGSG_05669
uniprot id: I1RNT1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG28 has a role as a scaffold to help anchor the catalytic components of the C-4 demethylation complex ERG25, ERG26 and ERG27 to the endoplasmic reticulum (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG…

229533:FGSG 10579
gene id: 229533:FGSG_10579
uniprot id: V6RS60
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12889
gene id: 229533:FGSG_12889
uniprot id: I1S7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Mitochondrion

229533:FGSG 08757
gene id: 229533:FGSG_08757
uniprot id: I1RWS7
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

229533:FGSG 08677
gene id: 229533:FGSG_08677
uniprot id: V6RKY8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

229533:FGSG 01470
gene id: 229533:FGSG_01470
uniprot id: I1RCY5
names: Similarity
messages: Belongs to the ZPR1 family.

229533:FGSG 00234
gene id: 229533:FGSG_00234
uniprot id: I1R9S6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 05454
gene id: 229533:FGSG_05454
uniprot id: I1RN88
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

229533:FGSG 08410
gene id: 229533:FGSG_08410
uniprot id: V6RKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06142
gene id: 229533:FGSG_06142
uniprot id: I1RQ09
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00571
gene id: 229533:FGSG_00571
uniprot id: I1RAN9
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

229533:FGSG 00524
gene id: 229533:FGSG_00524
uniprot id: I1RAJ4
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

229533:FGSG 12131
gene id: 229533:FGSG_12131
uniprot id: I1S5L0
names: Function
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

229533:FGSG 00367
gene id: 229533:FGSG_00367
uniprot id: I1RA43
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

229533:FGSG 11658
gene id: 229533:FGSG_11658
uniprot id: I1S491
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Abolishes the production of gramillins A and B.
messages: Nucleus
messages: Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves.

229533:FGSG 02624
gene id: 229533:FGSG_02624
uniprot id: I1RFY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

229533:FGSG 00372
gene id: 229533:FGSG_00372
uniprot id: I1RA48
names: Similarity
messages: Belongs to the CBF/MAK21 family.

229533:FGSG 05251
gene id: 229533:FGSG_05251
uniprot id: I1RMQ6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

229533:FGSG 07467
gene id: 229533:FGSG_07467
uniprot id: I1RTG3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

229533:FGSG 00421
gene id: 229533:FGSG_00421
uniprot id: I1RA94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

229533:FGSG 00787
gene id: 229533:FGSG_00787
uniprot id: I1RB80
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12996
gene id: 229533:FGSG_12996
uniprot id: A0A1I9FI54
uniprot id: Q4I7G0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH4 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
messages: The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

229533:FGSG 10911
gene id: 229533:FGSG_10911
uniprot id: Q4HVU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).

229533:FGSG 01095
gene id: 229533:FGSG_01095
uniprot id: I1RBZ6
names: Similarity
messages: Belongs to the peptidase S9C family.

229533:FGSG 10636
gene id: 229533:FGSG_10636
uniprot id: I1S1M9
names: Similarity
messages: Belongs to the TCTP family.

229533:FGSG 01490
gene id: 229533:FGSG_01490
uniprot id: I1RD03
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

229533:FGSG 09028
gene id: 229533:FGSG_09028
uniprot id: I1RXG0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 05269
gene id: 229533:FGSG_05269
uniprot id: I1RMS2
names: Similarity
messages: Belongs to the XPC family.

229533:FGSG 09321
gene id: 229533:FGSG_09321
uniprot id: I1RY81
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG10B catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.
messages: Homotetramer.
messages: cytosol

229533:FGSG 03772
gene id: 229533:FGSG_03772
uniprot id: I1RIX5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07886
gene id: 229533:FGSG_07886
uniprot id: I1RUJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

229533:FGSG 03778
gene id: 229533:FGSG_03778
uniprot id: I1RIY1
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 03083
gene id: 229533:FGSG_03083
uniprot id: I1RH42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 04309
gene id: 229533:FGSG_04309
uniprot id: I1RKB2
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

229533:FGSG 00797
gene id: 229533:FGSG_00797
uniprot id: I1RB88
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

229533:FGSG 09662
gene id: 229533:FGSG_09662
uniprot id: I1RZ39
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

229533:FGSG 09707
gene id: 229533:FGSG_09707
uniprot id: I1RZ80
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

229533:FGSG 04351
gene id: 229533:FGSG_04351
uniprot id: I1RKE9
names: Similarity
messages: Belongs to the WD repeat WDR48 family.

229533:FGSG 06945
gene id: 229533:FGSG_06945
uniprot id: I1RS38
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: Membrane
messages: actin patch

229533:FGSG 04621
gene id: 229533:FGSG_04621
uniprot id: I1RL41
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

229533:FGSG 00017
gene id: 229533:FGSG_00017
uniprot id: I1R989
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 04909
gene id: 229533:FGSG_04909
uniprot id: I1RLU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

229533:FGSG 10935
gene id: 229533:FGSG_10935
uniprot id: I1S2E3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04616
gene id: 229533:FGSG_04616
uniprot id: I1RL36
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 10737
gene id: 229533:FGSG_10737
uniprot id: I1S1W3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

229533:FGSG 01807
gene id: 229533:FGSG_01807
uniprot id: I1RDU0
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

229533:FGSG 05801
gene id: 229533:FGSG_05801
uniprot id: I1RP49
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13111
gene id: 229533:FGSG_13111
uniprot id: I1S8D3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

229533:FGSG 06916
gene id: 229533:FGSG_06916
uniprot id: I1RS12
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08988
gene id: 229533:FGSG_08988
uniprot id: I1RXC4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

229533:FGSG 04948
gene id: 229533:FGSG_04948
uniprot id: I1RLX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

229533:FGSG 06336
gene id: 229533:FGSG_06336
uniprot id: I1RQJ2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02354
gene id: 229533:FGSG_02354
uniprot id: I1RF87
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 02978
gene id: 229533:FGSG_02978
uniprot id: V6R7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10269
gene id: 229533:FGSG_10269
uniprot id: I1S0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

229533:FGSG 12427
gene id: 229533:FGSG_12427
uniprot id: I1S6F6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07214
gene id: 229533:FGSG_07214
uniprot id: I1RST1
names: Similarity
messages: Belongs to the CWC22 family.

229533:FGSG 10863
gene id: 229533:FGSG_10863
uniprot id: I1S277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

229533:FGSG 00638
gene id: 229533:FGSG_00638
uniprot id: I1RAV0
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

229533:FGSG 09990
gene id: 229533:FGSG_09990
uniprot id: I1RZY0
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

229533:FGSG 04178
gene id: 229533:FGSG_04178
uniprot id: I1RJZ4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07544
gene id: 229533:FGSG_07544
uniprot id: I1RTN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09056
gene id: 229533:FGSG_09056
uniprot id: I1RXI6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03965
gene id: 229533:FGSG_03965
uniprot id: I1RJE9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

229533:FGSG 01069
gene id: 229533:FGSG_01069
uniprot id: I1RBX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

229533:FGSG 10860
gene id: 229533:FGSG_10860
uniprot id: I1S274
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

229533:FGSG 04689
gene id: 229533:FGSG_04689
uniprot id: I1RLA3
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 05384
gene id: 229533:FGSG_05384
uniprot id: I1RN23
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08614
gene id: 229533:FGSG_08614
uniprot id: I1RWE8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 06523
gene id: 229533:FGSG_06523
uniprot id: I1RR19
names: Similarity
messages: Belongs to the thioesterase PaaI family.

229533:FGSG 04537
gene id: 229533:FGSG_04537
uniprot id: I1RKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03648
gene id: 229533:FGSG_03648
uniprot id: V6R4J6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 02137
gene id: 229533:FGSG_02137
uniprot id: I1REP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane

229533:FGSG 03032
gene id: 229533:FGSG_03032
uniprot id: I1RGZ8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03279
gene id: 229533:FGSG_03279
uniprot id: I1RHM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 02115
gene id: 229533:FGSG_02115
uniprot id: I1REM3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02931
gene id: 229533:FGSG_02931
uniprot id: I1RGQ8
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 05907
gene id: 229533:FGSG_05907
uniprot id: I1RPE0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

229533:FGSG 07924
gene id: 229533:FGSG_07924
uniprot id: I1RUM5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08394
gene id: 229533:FGSG_08394
uniprot id: I1RVU9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

229533:FGSG 00134
gene id: 229533:FGSG_00134
uniprot id: I1R9J2
names: Similarity
messages: Belongs to the aegerolysin family.

229533:FGSG 10308
gene id: 229533:FGSG_10308
uniprot id: I1S0S1
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

229533:FGSG 05671
gene id: 229533:FGSG_05671
uniprot id: I1RNT2
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

229533:FGSG 08588
gene id: 229533:FGSG_08588
uniprot id: I1RWC4
names: Similarity
messages: Belongs to the pirin family.

229533:FGSG 04886
gene id: 229533:FGSG_04886
uniprot id: V6R9Z3
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

229533:FGSG 04757
gene id: 229533:FGSG_04757
uniprot id: I1RLG0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00592
gene id: 229533:FGSG_00592
uniprot id: I1RAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Nucleus
messages: telomere

229533:FGSG 08706
gene id: 229533:FGSG_08706
uniprot id: I1RWN0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

229533:FGSG 07125
gene id: 229533:FGSG_07125
uniprot id: I1RSK3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03747
gene id: 229533:FGSG_03747
uniprot id: I1RIV2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Leads to increased sensitivity to oxidative stress and raduces the virulence toward wheat plants (PubMed:17056706).
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). NPS6 contains a degenerate A domain (dA) in the second module and has the following architecture: A-T-C-dA-T-T-C (PubMed:17056706).
messages: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).

229533:FGSG 08014
gene id: 229533:FGSG_08014
uniprot id: I1RUV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10676
gene id: 229533:FGSG_10676
uniprot id: I1S1R1
names: Subcellular Location Annotation
messages: Cell surface

229533:FGSG 00116
gene id: 229533:FGSG_00116
uniprot id: I1R9H5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05323
gene id: 229533:FGSG_05323
uniprot id: I1RMX0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

229533:FGSG 03107
gene id: 229533:FGSG_03107
uniprot id: I1RH63
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04590
gene id: 229533:FGSG_04590
uniprot id: I1RL13
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: Membrane

229533:FGSG 06070
gene id: 229533:FGSG_06070
uniprot id: I1RPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

229533:FGSG 01604
gene id: 229533:FGSG_01604
uniprot id: I1RDB0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

229533:FGSG 09045
gene id: 229533:FGSG_09045
uniprot id: I1RXH6
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

229533:FGSG 09921
gene id: 229533:FGSG_09921
uniprot id: I1RZR8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09870
gene id: 229533:FGSG_09870
uniprot id: I1RZM1
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

229533:FGSG 12606
gene id: 229533:FGSG_12606
uniprot id: I1S6Y3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01467
gene id: 229533:FGSG_01467
uniprot id: I1RCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

229533:FGSG 13493
gene id: 229533:FGSG_13493
uniprot id: I1S9G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the putative lipase ROG1 family.
messages: Membrane

229533:FGSG 05683
gene id: 229533:FGSG_05683
uniprot id: I1RNU3
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 05297
gene id: 229533:FGSG_05297
uniprot id: I1RMU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.

229533:FGSG 00722
gene id: 229533:FGSG_00722
uniprot id: V6QVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

229533:FGSG 03603
gene id: 229533:FGSG_03603
uniprot id: I1RIH0
names: Subcellular Location Annotation
messages: cytosol

229533:FGSG 00408
gene id: 229533:FGSG_00408
uniprot id: I1RA81
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

229533:FGSG 01972
gene id: 229533:FGSG_01972
uniprot id: I1RE90
names: Similarity
messages: In the N-terminal section; belongs to the cytochrome P450 family.

229533:FGSG 01498
gene id: 229533:FGSG_01498
uniprot id: I1RD11
names: Similarity
messages: Belongs to the RMD1/sif2 family.

229533:FGSG 01757
gene id: 229533:FGSG_01757
uniprot id: V6QXN0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

229533:FGSG 03728
gene id: 229533:FGSG_03728
uniprot id: I1RIT4
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 00626
gene id: 229533:FGSG_00626
uniprot id: I1RAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

229533:FGSG 06477
gene id: 229533:FGSG_06477
uniprot id: I1RQX6
names: Similarity
messages: Belongs to the scytalone dehydratase family.

229533:FGSG 00886
gene id: 229533:FGSG_00886
uniprot id: I1RBG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
messages: cytoskeleton
messages: nuclear pore complex

229533:FGSG 07888
gene id: 229533:FGSG_07888
uniprot id: V6RI16
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

229533:FGSG 05696
gene id: 229533:FGSG_05696
uniprot id: I1RNV4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 05203
gene id: 229533:FGSG_05203
uniprot id: I1RML2
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

229533:FGSG 05377
gene id: 229533:FGSG_05377
uniprot id: A0A1I9FQ28
uniprot id: Q4IBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
messages: cytosol

229533:FGSG 00649
gene id: 229533:FGSG_00649
uniprot id: I1RAW0
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

229533:FGSG 10862
gene id: 229533:FGSG_10862
uniprot id: I1S276
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

229533:FGSG 13445
gene id: 229533:FGSG_13445
uniprot id: I1S9B5
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 04312
gene id: 229533:FGSG_04312
uniprot id: V6R3J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

229533:FGSG 00399
gene id: 229533:FGSG_00399
uniprot id: I1RA73
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04039
gene id: 229533:FGSG_04039
uniprot id: I1RJL4
names: Similarity
messages: Belongs to the RRP1 family.

229533:FGSG 09974
gene id: 229533:FGSG_09974
uniprot id: I1RZW8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

229533:FGSG 07480
gene id: 229533:FGSG_07480
uniprot id: I1RTH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

229533:FGSG 03745
gene id: 229533:FGSG_03745
uniprot id: I1RIV0
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

229533:FGSG 05263
gene id: 229533:FGSG_05263
uniprot id: I1RMR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

229533:FGSG 07274
gene id: 229533:FGSG_07274
uniprot id: I1RSY7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

229533:FGSG 01511
gene id: 229533:FGSG_01511
uniprot id: I1RD24
names: Similarity
messages: Belongs to the synembryn family.

229533:FGSG 07775
gene id: 229533:FGSG_07775
uniprot id: I1RU91
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 00520
gene id: 229533:FGSG_00520
uniprot id: I1RAJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probable lipid hydrolase.

229533:FGSG 06640
gene id: 229533:FGSG_06640
uniprot id: I1RRC2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

229533:FGSG 04911
gene id: 229533:FGSG_04911
uniprot id: I1RLU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: May function both as a monomer and a homodimer.

229533:FGSG 03260
gene id: 229533:FGSG_03260
uniprot id: I1RHK3
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 03975
gene id: 229533:FGSG_03975
uniprot id: I1RJF8
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 03278
gene id: 229533:FGSG_03278
uniprot id: I1RHL9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

229533:FGSG 03869
gene id: 229533:FGSG_03869
uniprot id: I1RJ65
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05631
gene id: 229533:FGSG_05631
uniprot id: I1RNP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

229533:FGSG 13007
gene id: 229533:FGSG_13007
uniprot id: I1S831
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 09663
gene id: 229533:FGSG_09663
uniprot id: I1RZ40
names: Similarity
messages: Belongs to the PAT1 family.

229533:FGSG 02657
gene id: 229533:FGSG_02657
uniprot id: I1RG09
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

229533:FGSG 00499
gene id: 229533:FGSG_00499
uniprot id: I1RAH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

229533:FGSG 13172
gene id: 229533:FGSG_13172
uniprot id: I1S8J4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09890
gene id: 229533:FGSG_09890
uniprot id: I1RZP0
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

229533:FGSG 13826
gene id: 229533:FGSG_13826
uniprot id: I1SAE5
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

229533:FGSG 05394
gene id: 229533:FGSG_05394
uniprot id: I1RN32
names: Similarity
messages: Belongs to the taffazin family.

229533:FGSG 07810
gene id: 229533:FGSG_07810
uniprot id: I1RUC2
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 11240
gene id: 229533:FGSG_11240
uniprot id: I1S371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 08492
gene id: 229533:FGSG_08492
uniprot id: I1RW38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Endosome membrane
messages: Membrane

229533:FGSG 11272
gene id: 229533:FGSG_11272
uniprot id: I1S397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 02706
gene id: 229533:FGSG_02706
uniprot id: I1RG57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

229533:FGSG 00283
gene id: 229533:FGSG_00283
uniprot id: I1R9W9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01450
gene id: 229533:FGSG_01450
uniprot id: I1RCW7
names: Similarity
messages: Belongs to the RCAN family.

229533:FGSG 00343
gene id: 229533:FGSG_00343
uniprot id: I1RA25
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

229533:FGSG 02163
gene id: 229533:FGSG_02163
uniprot id: I1RER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

229533:FGSG 06384
gene id: 229533:FGSG_06384
uniprot id: I1RQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

229533:FGSG 02111
gene id: 229533:FGSG_02111
uniprot id: I1REL9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 09721
gene id: 229533:FGSG_09721
uniprot id: I1RZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the END3 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: Membrane
messages: actin patch

229533:FGSG 06064
gene id: 229533:FGSG_06064
uniprot id: I1RPT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

229533:FGSG 04980
gene id: 229533:FGSG_04980
uniprot id: I1RM07
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

229533:FGSG 03675
gene id: 229533:FGSG_03675
uniprot id: V6R6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Membrane
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

229533:FGSG 11617
gene id: 229533:FGSG_11617
uniprot id: I1S456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

229533:FGSG 02441
gene id: 229533:FGSG_02441
uniprot id: I1RFG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

229533:FGSG 08675
gene id: 229533:FGSG_08675
uniprot id: Q4I283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

229533:FGSG 10899
gene id: 229533:FGSG_10899
uniprot id: I1S2B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome

229533:FGSG 11260
gene id: 229533:FGSG_11260
uniprot id: V6RWE8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 01986
gene id: 229533:FGSG_01986
uniprot id: I1REA4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09429
gene id: 229533:FGSG_09429
uniprot id: I1RYH6
names: Similarity
messages: Belongs to the NipSnap family.

229533:FGSG 00796
gene id: 229533:FGSG_00796
uniprot id: I1RB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

229533:FGSG 06113
gene id: 229533:FGSG_06113
uniprot id: I1RPY1
names: Similarity
messages: Belongs to the RRP15 family.

229533:FGSG 04773
gene id: 229533:FGSG_04773
uniprot id: I1RLH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 06506
gene id: 229533:FGSG_06506
uniprot id: I1RR04
names: Similarity
messages: Belongs to the polysaccharide monooxygenase AA13 family.

229533:FGSG 09204
gene id: 229533:FGSG_09204
uniprot id: I1RXX8
names: Similarity
messages: Belongs to the peptidase C14B family.

229533:FGSG 10179
gene id: 229533:FGSG_10179
uniprot id: I1S0F5
names: Function
names: Similarity
messages: Belongs to the MBF1 family.
messages: Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.

229533:FGSG 07962
gene id: 229533:FGSG_07962
uniprot id: I1RUR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 01278
gene id: 229533:FGSG_01278
uniprot id: I1RCG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

229533:FGSG 09589
gene id: 229533:FGSG_09589
uniprot id: I1RYX6
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

229533:FGSG 04969
gene id: 229533:FGSG_04969
uniprot id: I1RLZ7
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 06235
gene id: 229533:FGSG_06235
uniprot id: V6RK66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02326
gene id: 229533:FGSG_02326
uniprot id: I1RF60
names: Function
names: Induction
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).
messages: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).

229533:FGSG 02589
gene id: 229533:FGSG_02589
uniprot id: I1RFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

229533:FGSG 12385
gene id: 229533:FGSG_12385
uniprot id: I1S6B4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07181
gene id: 229533:FGSG_07181
uniprot id: I1RSQ3
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

229533:FGSG 03861
gene id: 229533:FGSG_03861
uniprot id: I1RJ58
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08700
gene id: 229533:FGSG_08700
uniprot id: I1RWM4
names: Similarity
messages: Belongs to the malate synthase family.

229533:FGSG 03930
gene id: 229533:FGSG_03930
uniprot id: I1RJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 11069
gene id: 229533:FGSG_11069
uniprot id: I1S2R7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11721
gene id: 229533:FGSG_11721
uniprot id: I1S4F4
names: Similarity
messages: Belongs to the arginase family.

229533:FGSG 01917
gene id: 229533:FGSG_01917
uniprot id: I1RE44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 08597
gene id: 229533:FGSG_08597
uniprot id: I1RWD3
names: Similarity
messages: Belongs to the DEAD box helicase family.

229533:FGSG 07632
gene id: 229533:FGSG_07632
uniprot id: I1RTW4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07504
gene id: 229533:FGSG_07504
uniprot id: I1RTJ6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01094
gene id: 229533:FGSG_01094
uniprot id: I1RBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

229533:FGSG 09795
gene id: 229533:FGSG_09795
uniprot id: I1RZF6
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 10291
gene id: 229533:FGSG_10291
uniprot id: I1S0Q5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06037
gene id: 229533:FGSG_06037
uniprot id: I1RPQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

229533:FGSG 07326
gene id: 229533:FGSG_07326
uniprot id: I1RT33
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

229533:FGSG 11193
gene id: 229533:FGSG_11193
uniprot id: I1S332
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

229533:FGSG 03447
gene id: 229533:FGSG_03447
uniprot id: I1RI26
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06894
gene id: 229533:FGSG_06894
uniprot id: I1RRZ0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

229533:FGSG 01200
gene id: 229533:FGSG_01200
uniprot id: I1RC97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

229533:FGSG 01656
gene id: 229533:FGSG_01656
uniprot id: I1RDG0
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

229533:FGSG 08920
gene id: 229533:FGSG_08920
uniprot id: I1RX70
names: Similarity
messages: Belongs to the peptidase C19 family.

229533:FGSG 07294
gene id: 229533:FGSG_07294
uniprot id: I1RT05
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

229533:FGSG 06823
gene id: 229533:FGSG_06823
uniprot id: I1RRT4
names: Subcellular Location Annotation
messages: cytoskeleton

229533:FGSG 07198
gene id: 229533:FGSG_07198
uniprot id: I1RSR7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08341
gene id: 229533:FGSG_08341
uniprot id: I1RVQ4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02756
gene id: 229533:FGSG_02756
uniprot id: I1RG99
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

229533:FGSG 06305
gene id: 229533:FGSG_06305
uniprot id: I1RQG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 00330
gene id: 229533:FGSG_00330
uniprot id: I1RA13
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

229533:FGSG 08924
gene id: 229533:FGSG_08924
uniprot id: I1RX74
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02064
gene id: 229533:FGSG_02064
uniprot id: I1REH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 04264
gene id: 229533:FGSG_04264
uniprot id: I1RK71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus

229533:FGSG 12443
gene id: 229533:FGSG_12443
uniprot id: I1S6H2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 10991
gene id: 229533:FGSG_10991
uniprot id: I1S2J5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochrome P450 monooxygenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.

229533:FGSG 07695
gene id: 229533:FGSG_07695
uniprot id: I1RU20
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 00824
gene id: 229533:FGSG_00824
uniprot id: I1RBB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

229533:FGSG 08128
gene id: 229533:FGSG_08128
uniprot id: I1RV65
names: Similarity
messages: Belongs to the SIP5 family.

229533:FGSG 07406
gene id: 229533:FGSG_07406
uniprot id: A0A1I9FJ43
uniprot id: Q4I5V2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 02168
gene id: 229533:FGSG_02168
uniprot id: I1RER8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 01552
gene id: 229533:FGSG_01552
uniprot id: I1RD63
names: Similarity
messages: Belongs to the VPS29 family.

229533:FGSG 02833
gene id: 229533:FGSG_02833
uniprot id: I1RGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 09466
gene id: 229533:FGSG_09466
uniprot id: I1RYL0
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 05048
gene id: 229533:FGSG_05048
uniprot id: I1RM66
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 05413
gene id: 229533:FGSG_05413
uniprot id: I1RN49
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10765
gene id: 229533:FGSG_10765
uniprot id: A0A1I9FWM3
uniprot id: Q4HW93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Cytoplasm
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
messages: Nucleus

229533:FGSG 03892
gene id: 229533:FGSG_03892
uniprot id: I1RJ84
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10669
gene id: 229533:FGSG_10669
uniprot id: V6RSF3
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

229533:FGSG 02105
gene id: 229533:FGSG_02105
uniprot id: I1REL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Membrane

229533:FGSG 04196
gene id: 229533:FGSG_04196
uniprot id: V6R3V4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 10446
gene id: 229533:FGSG_10446
uniprot id: I1S149
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

229533:FGSG 02308
gene id: 229533:FGSG_02308
uniprot id: I1RF42
names: Similarity
messages: Belongs to the DSD1 family.

229533:FGSG 08545
gene id: 229533:FGSG_08545
uniprot id: I1RW84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: Membrane

229533:FGSG 11128
gene id: 229533:FGSG_11128
uniprot id: V6RUB1
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

229533:FGSG 05443
gene id: 229533:FGSG_05443
uniprot id: I1RN77
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

229533:FGSG 07524
gene id: 229533:FGSG_07524
uniprot id: A0A1I9FH61
uniprot id: Q4I5I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.

229533:FGSG 01964
gene id: 229533:FGSG_01964
uniprot id: I1RE84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 04876
gene id: 229533:FGSG_04876
uniprot id: I1RLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 06003
gene id: 229533:FGSG_06003
uniprot id: I1RPM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHS7 family.
messages: Membrane

229533:FGSG 03898
gene id: 229533:FGSG_03898
uniprot id: I1RJ90
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 03373
gene id: 229533:FGSG_03373
uniprot id: I1RHV8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 12704
gene id: 229533:FGSG_12704
uniprot id: I1S781
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02073
gene id: 229533:FGSG_02073
uniprot id: I1REI4
names: Similarity
messages: Belongs to the lysophospholipase family.

229533:FGSG 10458
gene id: 229533:FGSG_10458
uniprot id: I1S160
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription regulator that specifically up-regulates the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016). Probably binds the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes (PubMed:22252016).

229533:FGSG 12471
gene id: 229533:FGSG_12471
uniprot id: I1S6J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 08398
gene id: 229533:FGSG_08398
uniprot id: I1RVV3
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

229533:FGSG 07401
gene id: 229533:FGSG_07401
uniprot id: I1RTA0
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 00363
gene id: 229533:FGSG_00363
uniprot id: I1RA40
names: Similarity
messages: Belongs to the TEL2 family.

229533:FGSG 03345
gene id: 229533:FGSG_03345
uniprot id: I1RHT2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02247
gene id: 229533:FGSG_02247
uniprot id: I1REY8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 02109
gene id: 229533:FGSG_02109
uniprot id: I1REL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 12856
gene id: 229533:FGSG_12856
uniprot id: I1S7N3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

229533:FGSG 06814
gene id: 229533:FGSG_06814
uniprot id: I1RRS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

229533:FGSG 08058
gene id: 229533:FGSG_08058
uniprot id: I1RUZ8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06586
gene id: 229533:FGSG_06586
uniprot id: I1RR72
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

229533:FGSG 03507
gene id: 229533:FGSG_03507
uniprot id: I1RI80
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 09893
gene id: 229533:FGSG_09893
uniprot id: I1RZP3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.
messages: Secreted

229533:FGSG 02306
gene id: 229533:FGSG_02306
uniprot id: I1RF40
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

229533:FGSG 11472
gene id: 229533:FGSG_11472
uniprot id: I1S3S6
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 00595
gene id: 229533:FGSG_00595
uniprot id: I1RAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

229533:FGSG 13258
gene id: 229533:FGSG_13258
uniprot id: I1S8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

229533:FGSG 01584
gene id: 229533:FGSG_01584
uniprot id: I1RD92
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02463
gene id: 229533:FGSG_02463
uniprot id: I1RFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00570
gene id: 229533:FGSG_00570
uniprot id: I1RAN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

229533:FGSG 01436
gene id: 229533:FGSG_01436
uniprot id: I1RCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.
messages: Nucleus

229533:FGSG 10933
gene id: 229533:FGSG_10933
uniprot id: I1S2E1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

229533:FGSG 01957
gene id: 229533:FGSG_01957
uniprot id: I1RE78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 10942
gene id: 229533:FGSG_10942
uniprot id: I1S2F0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

229533:FGSG 08425
gene id: 229533:FGSG_08425
uniprot id: I1RVX8
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

229533:FGSG 06955
gene id: 229533:FGSG_06955
uniprot id: I1RS47
names: Similarity
messages: Belongs to the peptidase M24 family.

229533:FGSG 02950
gene id: 229533:FGSG_02950
uniprot id: I1RGS5
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 09545
gene id: 229533:FGSG_09545
uniprot id: I1RYT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

229533:FGSG 00725
gene id: 229533:FGSG_00725
uniprot id: I1RB21
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11398
gene id: 229533:FGSG_11398
uniprot id: I1S3L0
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).

229533:FGSG 02976
gene id: 229533:FGSG_02976
uniprot id: I1RGU8
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 03432
gene id: 229533:FGSG_03432
uniprot id: I1RI12
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 06960
gene id: 229533:FGSG_06960
uniprot id: I1RS50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.
messages: Mitochondrion inner membrane

229533:FGSG 06047
gene id: 229533:FGSG_06047
uniprot id: I1RPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Chromosome

229533:FGSG 08761
gene id: 229533:FGSG_08761
uniprot id: V6RRH2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

229533:FGSG 00501
gene id: 229533:FGSG_00501
uniprot id: A0A1I9EVR0
uniprot id: Q4IQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

229533:FGSG 00946
gene id: 229533:FGSG_00946
uniprot id: I1RBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

229533:FGSG 07436
gene id: 229533:FGSG_07436
uniprot id: I1RTD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

229533:FGSG 10417
gene id: 229533:FGSG_10417
uniprot id: I1S123
names: Similarity
messages: Belongs to the thioredoxin family.

229533:FGSG 04245
gene id: 229533:FGSG_04245
uniprot id: I1RK57
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

229533:FGSG 05322
gene id: 229533:FGSG_05322
uniprot id: I1RMW9
names: Similarity
messages: Belongs to the fungal fatty acid synthetase subunit beta family.

229533:FGSG 10445
gene id: 229533:FGSG_10445
uniprot id: I1S148
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

229533:FGSG 05194
gene id: 229533:FGSG_05194
uniprot id: V6R9P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

229533:FGSG 01762
gene id: 229533:FGSG_01762
uniprot id: I1RDP8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04461
gene id: 229533:FGSG_04461
uniprot id: I1RKP8
names: Similarity
messages: Belongs to the paxB family.

229533:FGSG 13984
gene id: 229533:FGSG_13984
uniprot id: I1SAV3
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 06619
gene id: 229533:FGSG_06619
uniprot id: V6REA4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 06864
gene id: 229533:FGSG_06864
uniprot id: I1RRW5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

229533:FGSG 00663
gene id: 229533:FGSG_00663
uniprot id: I1RAW9
names: Function
names: Similarity
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.

229533:FGSG 04998
gene id: 229533:FGSG_04998
uniprot id: I1RM23
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

229533:FGSG 05802
gene id: 229533:FGSG_05802
uniprot id: I1RP50
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03306
gene id: 229533:FGSG_03306
uniprot id: I1RHP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00495
gene id: 229533:FGSG_00495
uniprot id: I1RAG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

229533:FGSG 04136
gene id: 229533:FGSG_04136
uniprot id: I1RJV3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

229533:FGSG 06167
gene id: 229533:FGSG_06167
uniprot id: I1RQ33
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

229533:FGSG 01171
gene id: 229533:FGSG_01171
uniprot id: I1RC68
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 03529
gene id: 229533:FGSG_03529
uniprot id: V6R5G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

229533:FGSG 02179
gene id: 229533:FGSG_02179
uniprot id: I1RES8
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

229533:FGSG 01169
gene id: 229533:FGSG_01169
uniprot id: I1RC66
names: Similarity
names: Subunit
messages: Belongs to the SIL1 family.
messages: Interacts with KAR2.

229533:FGSG 08382
gene id: 229533:FGSG_08382
uniprot id: I1RVT8
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

229533:FGSG 02330
gene id: 229533:FGSG_02330
uniprot id: I1RF64
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the multicopper oxidase family.
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).
messages: Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:16879655).
messages: Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).

229533:FGSG 13662
gene id: 229533:FGSG_13662
uniprot id: I1S9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

229533:FGSG 09660
gene id: 229533:FGSG_09660
uniprot id: I1RZ37
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

229533:FGSG 13866
gene id: 229533:FGSG_13866
uniprot id: I1SAI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01504
gene id: 229533:FGSG_01504
uniprot id: I1RD17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

229533:FGSG 00348
gene id: 229533:FGSG_00348
uniprot id: V6R0U9
names: Similarity
messages: Belongs to the argonaute family.

229533:FGSG 03645
gene id: 229533:FGSG_03645
uniprot id: I1RIK8
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

229533:FGSG 02697
gene id: 229533:FGSG_02697
uniprot id: I1RG48
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10126
gene id: 229533:FGSG_10126
uniprot id: I1S0A5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

229533:FGSG 05972
gene id: 229533:FGSG_05972
uniprot id: I1RPK0
names: Similarity
messages: Belongs to the NDK family.

229533:FGSG 05882
gene id: 229533:FGSG_05882
uniprot id: I1RPC0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 07970
gene id: 229533:FGSG_07970
uniprot id: I1RUR8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

229533:FGSG 03159
gene id: 229533:FGSG_03159
uniprot id: I1RHB3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03963
gene id: 229533:FGSG_03963
uniprot id: I1RJE7
names: Similarity
messages: Belongs to the amidase family.

229533:FGSG 07202
gene id: 229533:FGSG_07202
uniprot id: I1RSS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

229533:FGSG 08811
gene id: 229533:FGSG_08811
uniprot id: I1RWX5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

229533:FGSG 01125
gene id: 229533:FGSG_01125
uniprot id: I1RC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

229533:FGSG 11211
gene id: 229533:FGSG_11211
uniprot id: I1S346
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 11339
gene id: 229533:FGSG_11339
uniprot id: I1S3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 07227
gene id: 229533:FGSG_07227
uniprot id: I1RSU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 09651
gene id: 229533:FGSG_09651
uniprot id: I1RZ33
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08012
gene id: 229533:FGSG_08012
uniprot id: I1RUV5
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 08932
gene id: 229533:FGSG_08932
uniprot id: Q4I1H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Prevacuolar compartment membrane
messages: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

229533:FGSG 07031
gene id: 229533:FGSG_07031
uniprot id: I1RSB7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

229533:FGSG 03657
gene id: 229533:FGSG_03657
uniprot id: I1RIL9
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 01395
gene id: 229533:FGSG_01395
uniprot id: I1RCR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Belongs to the paxM FAD-dependent monooxygenase family.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

229533:FGSG 09309
gene id: 229533:FGSG_09309
uniprot id: I1RY72
names: Similarity
messages: Belongs to the peptidase M24B family.

229533:FGSG 01443
gene id: 229533:FGSG_01443
uniprot id: I1RCW0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

229533:FGSG 01884
gene id: 229533:FGSG_01884
uniprot id: I1RE12
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 02469
gene id: 229533:FGSG_02469
uniprot id: I1RFJ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-211 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus

229533:FGSG 07268
gene id: 229533:FGSG_07268
uniprot id: I1RSY1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

229533:FGSG 05404
gene id: 229533:FGSG_05404
uniprot id: I1RN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

229533:FGSG 08037
gene id: 229533:FGSG_08037
uniprot id: I1RUX8
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 04284
gene id: 229533:FGSG_04284
uniprot id: I1RK90
names: Similarity
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.

229533:FGSG 04181
gene id: 229533:FGSG_04181
uniprot id: I1RJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: cytoskeleton

229533:FGSG 09630
gene id: 229533:FGSG_09630
uniprot id: I1RZ12
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 01212
gene id: 229533:FGSG_01212
uniprot id: I1RCA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

229533:FGSG 03933
gene id: 229533:FGSG_03933
uniprot id: I1RJC2
names: Similarity
messages: Belongs to the Cyclase 1 superfamily.

229533:FGSG 09440
gene id: 229533:FGSG_09440
uniprot id: I1RYI7
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

229533:FGSG 03951
gene id: 229533:FGSG_03951
uniprot id: I1RJD6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFA/CMAS family.
messages: Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in the growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. However, C-9 methylation of GlcCers is not essential for the sensitivity of F.graminearum to plant defensins MsDef1 and RsAFP2.
messages: In contrast to the knockout of its paralog MT2, has no effect on methylation of GluCers and exhibits no growth defects. However, a double-knockout with its paralog MT2 is not viable.
messages: Membrane

229533:FGSG 07129
gene id: 229533:FGSG_07129
uniprot id: I1RSK7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05450
gene id: 229533:FGSG_05450
uniprot id: I1RN84
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

229533:FGSG 00811
gene id: 229533:FGSG_00811
uniprot id: V6QVS3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Leads to whitish colonies with longer aerial hyphae and reduced conidiation and perithecium formation, with morphologically abnormal conidia that undergo abnormal germination (PubMed:29502265). Increases the conidium autophagy (PubMed:29502265). Results in a significant higher production of deoxynivalenol (DON) but does not affect pathogenicity (PubMed:29502265). Exhibits increased resistance to osmotic and oxidative stress as well as cell-wall perturbing agents (PubMed:29502265).
messages: Nucleus membrane
messages: Probable water channel involved in responses to changes in environmental conditions and conidiation (PubMed:29502265). Involved in responses to hyperosmotic conditions, oxidative stress and cell wall destabilization (PubMed:29502265). Also required for proper transcriptional activation of genes involved in aurofusarin biosynthesis (PubMed:29502265). Not involved in pathogenicity, but negatively regulates deoxynivalenol (DON) production (PubMed:29502265).

229533:FGSG 01558
gene id: 229533:FGSG_01558
uniprot id: I1RD69
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

229533:FGSG 08393
gene id: 229533:FGSG_08393
uniprot id: I1RVU8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01948
gene id: 229533:FGSG_01948
uniprot id: I1RE71
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 09313
gene id: 229533:FGSG_09313
uniprot id: I1RY75
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 09003
gene id: 229533:FGSG_09003
uniprot id: I1RXD7
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

229533:FGSG 01620
gene id: 229533:FGSG_01620
uniprot id: I1RDC6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01280
gene id: 229533:FGSG_01280
uniprot id: I1RCG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 10490
gene id: 229533:FGSG_10490
uniprot id: I1S190
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00721
gene id: 229533:FGSG_00721
uniprot id: I1RB18
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 01166
gene id: 229533:FGSG_01166
uniprot id: I1RC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

229533:FGSG 06921
gene id: 229533:FGSG_06921
uniprot id: I1RS17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

229533:FGSG 01432
gene id: 229533:FGSG_01432
uniprot id: I1RCV0
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

229533:FGSG 08554
gene id: 229533:FGSG_08554
uniprot id: I1RW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 12398
gene id: 229533:FGSG_12398
uniprot id: I1S6C7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 13185
gene id: 229533:FGSG_13185
uniprot id: I1S8K7
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 11358
gene id: 229533:FGSG_11358
uniprot id: I1S3H6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07808
gene id: 229533:FGSG_07808
uniprot id: I1RUC0
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 02384
gene id: 229533:FGSG_02384
uniprot id: I1RFB5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10864
gene id: 229533:FGSG_10864
uniprot id: I1S278
names: Similarity
messages: Belongs to the syntaxin family.

229533:FGSG 04612
gene id: 229533:FGSG_04612
uniprot id: I1RL32
names: Function
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.

229533:FGSG 07189
gene id: 229533:FGSG_07189
uniprot id: V6RGM9
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 04105
gene id: 229533:FGSG_04105
uniprot id: I1RJS3
names: Similarity
messages: Belongs to the phosducin family.

229533:FGSG 06769
gene id: 229533:FGSG_06769
uniprot id: A0A1I9FKB9
uniprot id: Q4I7N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
messages: Nucleus

229533:FGSG 09736
gene id: 229533:FGSG_09736
uniprot id: I1RZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 04251
gene id: 229533:FGSG_04251
uniprot id: I1RK61
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 08803
gene id: 229533:FGSG_08803
uniprot id: I1RWW7
names: Similarity
messages: Belongs to the PPC synthetase family.

229533:FGSG 01290
gene id: 229533:FGSG_01290
uniprot id: I1RCH5
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

229533:FGSG 08943
gene id: 229533:FGSG_08943
uniprot id: I1RX89
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 05421
gene id: 229533:FGSG_05421
uniprot id: I1RN57
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

229533:FGSG 11567
gene id: 229533:FGSG_11567
uniprot id: I1S414
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00930
gene id: 229533:FGSG_00930
uniprot id: A0A1I9EX23
uniprot id: Q4IPC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

229533:FGSG 05491
gene id: 229533:FGSG_05491
uniprot id: V6R3L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

229533:FGSG 05644
gene id: 229533:FGSG_05644
uniprot id: I1RNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

229533:FGSG 10839
gene id: 229533:FGSG_10839
uniprot id: I1S255
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

229533:FGSG 10879
gene id: 229533:FGSG_10879
uniprot id: I1S293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

229533:FGSG 03249
gene id: 229533:FGSG_03249
uniprot id: I1RHJ2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

229533:FGSG 05705
gene id: 229533:FGSG_05705
uniprot id: I1RNW3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11548
gene id: 229533:FGSG_11548
uniprot id: I1S3Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 05428
gene id: 229533:FGSG_05428
uniprot id: I1RN63
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

229533:FGSG 01605
gene id: 229533:FGSG_01605
uniprot id: I1RDB1
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 03055
gene id: 229533:FGSG_03055
uniprot id: I1RH18
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05360
gene id: 229533:FGSG_05360
uniprot id: I1RN04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 05224
gene id: 229533:FGSG_05224
uniprot id: I1RMN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

229533:FGSG 07195
gene id: 229533:FGSG_07195
uniprot id: I1RSR4
names: Similarity
messages: Belongs to the LTV1 family.

229533:FGSG 06628
gene id: 229533:FGSG_06628
uniprot id: A0A1I9FLS8
uniprot id: Q4I830
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in ribosome assembly.
messages: Associates with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 01909
gene id: 229533:FGSG_01909
uniprot id: I1RE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

229533:FGSG 11181
gene id: 229533:FGSG_11181
uniprot id: I1S320
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 09592
gene id: 229533:FGSG_09592
uniprot id: I1RYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

229533:FGSG 10903
gene id: 229533:FGSG_10903
uniprot id: I1S2B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

229533:FGSG 09297
gene id: 229533:FGSG_09297
uniprot id: I1RY60
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09099
gene id: 229533:FGSG_09099
uniprot id: I1RXM5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 04527
gene id: 229533:FGSG_04527
uniprot id: I1RKV6
names: Similarity
messages: Belongs to the peptidase S10 family.

229533:FGSG 00612
gene id: 229533:FGSG_00612
uniprot id: V6QU20
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 09063
gene id: 229533:FGSG_09063
uniprot id: I1RXJ2
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 05026
gene id: 229533:FGSG_05026
uniprot id: I1RM47
names: Similarity
messages: Belongs to the peptidase C48 family.

229533:FGSG 09319
gene id: 229533:FGSG_09319
uniprot id: I1RY80
names: Similarity
messages: Belongs to the MIP18 family.

229533:FGSG 03991
gene id: 229533:FGSG_03991
uniprot id: I1RJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

229533:FGSG 02395
gene id: 229533:FGSG_02395
uniprot id: A0A098D6U0
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
messages: Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).
messages: Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (By similarity).
messages: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEA1 exhibits broad starter-unit specificities toward fatty acyl-CoAs ranging in sizes between C6 and C16 and displays the highest activity toward decanoyl-CoA (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).
messages: Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793, PubMed:16517624).
messages: The release of the polyketide chain from the non-reducing polyketide synthase is mediated by the thioesterase (TE) domain localized at the C-ter of the protein (By similarity).

229533:FGSG 00762
gene id: 229533:FGSG_00762
uniprot id: I1RB55
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 06096
gene id: 229533:FGSG_06096
uniprot id: I1RPW4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

229533:FGSG 11122
gene id: 229533:FGSG_11122
uniprot id: I1S2W6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05797
gene id: 229533:FGSG_05797
uniprot id: I1RP45
names: Similarity
messages: Belongs to the peptidase S10 family.

229533:FGSG 05584
gene id: 229533:FGSG_05584
uniprot id: I1RNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 09555
gene id: 229533:FGSG_09555
uniprot id: I1RYU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

229533:FGSG 12390
gene id: 229533:FGSG_12390
uniprot id: I1S6B9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 05074
gene id: 229533:FGSG_05074
uniprot id: I1RM89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

229533:FGSG 00916
gene id: 229533:FGSG_00916
uniprot id: I1RBJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

229533:FGSG 08897
gene id: 229533:FGSG_08897
uniprot id: I1RX47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

229533:FGSG 09220
gene id: 229533:FGSG_09220
uniprot id: I1RXZ3
names: Similarity
messages: Belongs to the MGR2 family.

229533:FGSG 13888
gene id: 229533:FGSG_13888
uniprot id: I1SAK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 11847
gene id: 229533:FGSG_11847
uniprot id: I1S4S9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09683
gene id: 229533:FGSG_09683
uniprot id: I1RZ57
names: Similarity
names: Subunit
messages: Belongs to the EXO5 family.
messages: Monomer.

229533:FGSG 07439
gene id: 229533:FGSG_07439
uniprot id: A0A1I9FLZ5
uniprot id: Q4I5R9
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Endoplasmic reticulum lumen
messages: Inhibited by cyclosporin A (CsA).
messages: Lacks the C-terminal transmembrane domain, but has an ER retention motif at its extreme C-terminus.
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 04704
gene id: 229533:FGSG_04704
uniprot id: I1RLB7
names: Similarity
messages: Belongs to the polysaccharide monooxygenase AA13 family.

229533:FGSG 06425
gene id: 229533:FGSG_06425
uniprot id: I1RQS6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05884
gene id: 229533:FGSG_05884
uniprot id: I1RPC2
names: Similarity
messages: Belongs to the CAND family.

229533:FGSG 01064
gene id: 229533:FGSG_01064
uniprot id: I1RBX1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03023
gene id: 229533:FGSG_03023
uniprot id: I1RGZ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03347
gene id: 229533:FGSG_03347
uniprot id: V6R610
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

229533:FGSG 01289
gene id: 229533:FGSG_01289
uniprot id: I1RCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

229533:FGSG 08931
gene id: 229533:FGSG_08931
uniprot id: I1RX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 00071
gene id: 229533:FGSG_00071
uniprot id: I1R9D6
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 02519
gene id: 229533:FGSG_02519
uniprot id: I1RFN8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2) (By similarity).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies (By similarity). Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles (By similarity). The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Prevacuolar compartment membrane
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Strongly reduces the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: multivesicular body membrane

229533:FGSG 01133
gene id: 229533:FGSG_01133
uniprot id: I1RC31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

229533:FGSG 02986
gene id: 229533:FGSG_02986
uniprot id: I1RGV6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 09344
gene id: 229533:FGSG_09344
uniprot id: I1RYA2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

229533:FGSG 01805
gene id: 229533:FGSG_01805
uniprot id: I1RDT8
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 07012
gene id: 229533:FGSG_07012
uniprot id: I1RS98
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 12358
gene id: 229533:FGSG_12358
uniprot id: I1S687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10231
gene id: 229533:FGSG_10231
uniprot id: I1S0K2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

229533:FGSG 07469
gene id: 229533:FGSG_07469
uniprot id: I1RTG5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

229533:FGSG 02460
gene id: 229533:FGSG_02460
uniprot id: I1RFI3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

229533:FGSG 07376
gene id: 229533:FGSG_07376
uniprot id: I1RT77
names: Similarity
messages: Belongs to the CutC family.

229533:FGSG 01622
gene id: 229533:FGSG_01622
uniprot id: I1RDC8
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

229533:FGSG 06605
gene id: 229533:FGSG_06605
uniprot id: I1RR89
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 09869
gene id: 229533:FGSG_09869
uniprot id: I1RZM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 13625
gene id: 229533:FGSG_13625
uniprot id: I1S9U4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03593
gene id: 229533:FGSG_03593
uniprot id: I1RIG1
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 03460
gene id: 229533:FGSG_03460
uniprot id: I1RI38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 09031
gene id: 229533:FGSG_09031
uniprot id: I1RXG2
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 07135
gene id: 229533:FGSG_07135
uniprot id: I1RSL2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

229533:FGSG 09633
gene id: 229533:FGSG_09633
uniprot id: I1RZ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 06021
gene id: 229533:FGSG_06021
uniprot id: I1RPP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

229533:FGSG 13755
gene id: 229533:FGSG_13755
uniprot id: I1SA74
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 07207
gene id: 229533:FGSG_07207
uniprot id: I1RSS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 06377
gene id: 229533:FGSG_06377
uniprot id: I1RQN1
names: Similarity
messages: Belongs to the UPF0696 family.

229533:FGSG 08139
gene id: 229533:FGSG_08139
uniprot id: I1RV75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 05359
gene id: 229533:FGSG_05359
uniprot id: I1RN03
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03139
gene id: 229533:FGSG_03139
uniprot id: I1RH94
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 07131
gene id: 229533:FGSG_07131
uniprot id: I1RSK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 13737
gene id: 229533:FGSG_13737
uniprot id: I1SA56
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00460
gene id: 229533:FGSG_00460
uniprot id: I1RAD3
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

229533:FGSG 01030
gene id: 229533:FGSG_01030
uniprot id: I1RBU0
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

229533:FGSG 13920
gene id: 229533:FGSG_13920
uniprot id: I1SAN9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03708
gene id: 229533:FGSG_03708
uniprot id: I1RIR5
names: Similarity
messages: Belongs to the chloroperoxidase family.

229533:FGSG 01098
gene id: 229533:FGSG_01098
uniprot id: I1RBZ9
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

229533:FGSG 08042
gene id: 229533:FGSG_08042
uniprot id: I1RUY3
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

229533:FGSG 06821
gene id: 229533:FGSG_06821
uniprot id: I1RRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 06068
gene id: 229533:FGSG_06068
uniprot id: I1RPT8
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 05198
gene id: 229533:FGSG_05198
uniprot id: I1RMK7
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.

229533:FGSG 01550
gene id: 229533:FGSG_01550
uniprot id: I1RD61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD2 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 09503
gene id: 229533:FGSG_09503
uniprot id: I1RYP5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

229533:FGSG 12884
gene id: 229533:FGSG_12884
uniprot id: I1S7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

229533:FGSG 09184
gene id: 229533:FGSG_09184
uniprot id: I1RXV8
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 06282
gene id: 229533:FGSG_06282
uniprot id: I1RQE1
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

229533:FGSG 05288
gene id: 229533:FGSG_05288
uniprot id: A0A1I9FQE3
uniprot id: Q4IBX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

229533:FGSG 08541
gene id: 229533:FGSG_08541
uniprot id: I1RW80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 10268
gene id: 229533:FGSG_10268
uniprot id: I1S0N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 09104
gene id: 229533:FGSG_09104
uniprot id: I1RXN0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11657
gene id: 229533:FGSG_11657
uniprot id: I1S490
names: Function
messages: Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 08312
gene id: 229533:FGSG_08312
uniprot id: I1RVN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 01973
gene id: 229533:FGSG_01973
uniprot id: I1RE91
names: Similarity
messages: Belongs to the phospholipase D family.

229533:FGSG 05150
gene id: 229533:FGSG_05150
uniprot id: Q4ICA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

229533:FGSG 10677
gene id: 229533:FGSG_10677
uniprot id: I1S1R2
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

229533:FGSG 05299
gene id: 229533:FGSG_05299
uniprot id: I1RMU9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

229533:FGSG 06300
gene id: 229533:FGSG_06300
uniprot id: I1RQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 10211
gene id: 229533:FGSG_10211
uniprot id: I1S0I3
names: Similarity
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

229533:FGSG 06299
gene id: 229533:FGSG_06299
uniprot id: I1RQF7
names: Similarity
messages: Belongs to the COG3 family.

229533:FGSG 10177
gene id: 229533:FGSG_10177
uniprot id: I1S0F3
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 13875
gene id: 229533:FGSG_13875
uniprot id: I1SAJ4
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 05541
gene id: 229533:FGSG_05541
uniprot id: I1RNG4
names: Function
messages: Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

229533:FGSG 06807
gene id: 229533:FGSG_06807
uniprot id: I1RRS1
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

229533:FGSG 02622
gene id: 229533:FGSG_02622
uniprot id: I1RFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

229533:FGSG 10744
gene id: 229533:FGSG_10744
uniprot id: I1S1W9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

229533:FGSG 08386
gene id: 229533:FGSG_08386
uniprot id: I1RVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 06104
gene id: 229533:FGSG_06104
uniprot id: I1RPX2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 08898
gene id: 229533:FGSG_08898
uniprot id: I1RX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

229533:FGSG 01475
gene id: 229533:FGSG_01475
uniprot id: I1RCY9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

229533:FGSG 13839
gene id: 229533:FGSG_13839
uniprot id: I1SAF8
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 12518
gene id: 229533:FGSG_12518
uniprot id: I1S6P5
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

229533:FGSG 13650
gene id: 229533:FGSG_13650
uniprot id: I1S9W9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09435
gene id: 229533:FGSG_09435
uniprot id: I1RYI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHO1 family.
messages: Cell membrane
messages: Forms homooligomers.
messages: Membrane

229533:FGSG 04672
gene id: 229533:FGSG_04672
uniprot id: I1RL86
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00615
gene id: 229533:FGSG_00615
uniprot id: I1RAS9
names: Function
names: Subcellular Location Annotation
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.
messages: Membrane
messages: Prevacuolar compartment membrane
messages: trans-Golgi network membrane

229533:FGSG 01603
gene id: 229533:FGSG_01603
uniprot id: I1RDA9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 07021
gene id: 229533:FGSG_07021
uniprot id: I1RSA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

229533:FGSG 01795
gene id: 229533:FGSG_01795
uniprot id: I1RDS9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07381
gene id: 229533:FGSG_07381
uniprot id: I1RT82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

229533:FGSG 00865
gene id: 229533:FGSG_00865
uniprot id: I1RBE7
names: Similarity
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

229533:FGSG 11027
gene id: 229533:FGSG_11027
uniprot id: I1S2M8
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

229533:FGSG 01391
gene id: 229533:FGSG_01391
uniprot id: I1RCR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

229533:FGSG 13120
gene id: 229533:FGSG_13120
uniprot id: I1S8E2
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 10387
gene id: 229533:FGSG_10387
uniprot id: I1S0Z5
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

229533:FGSG 00144
gene id: 229533:FGSG_00144
uniprot id: I1R9K1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04804
gene id: 229533:FGSG_04804
uniprot id: I1RLK1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03063
gene id: 229533:FGSG_03063
uniprot id: V6R6H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 06339
gene id: 229533:FGSG_06339
uniprot id: I1RQJ4
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

229533:FGSG 11417
gene id: 229533:FGSG_11417
uniprot id: I1S3M7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02839
gene id: 229533:FGSG_02839
uniprot id: V6R882
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

229533:FGSG 10272
gene id: 229533:FGSG_10272
uniprot id: I1S0N8
names: Similarity
messages: Belongs to the RSP5/NEDD4 family.

229533:FGSG 00299
gene id: 229533:FGSG_00299
uniprot id: I1R9Y3
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

229533:FGSG 09409
gene id: 229533:FGSG_09409
uniprot id: I1RYF9
names: Function
names: Similarity
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.

229533:FGSG 02688
gene id: 229533:FGSG_02688
uniprot id: I1RG39
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07606
gene id: 229533:FGSG_07606
uniprot id: I1RTU0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 01276
gene id: 229533:FGSG_01276
uniprot id: I1RCG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

229533:FGSG 11629
gene id: 229533:FGSG_11629
uniprot id: Q4HTS9
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

229533:FGSG 00405
gene id: 229533:FGSG_00405
uniprot id: I1RA78
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10961
gene id: 229533:FGSG_10961
uniprot id: I1S2G7
names: Similarity
messages: Belongs to the peptidase M67C family.

229533:FGSG 06244
gene id: 229533:FGSG_06244
uniprot id: I1RQA3
names: Subcellular Location Annotation
messages: cytosol

229533:FGSG 04026
gene id: 229533:FGSG_04026
uniprot id: I1RJK3
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 05316
gene id: 229533:FGSG_05316
uniprot id: I1RMW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

229533:FGSG 01308
gene id: 229533:FGSG_01308
uniprot id: I1RCJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
messages: Vacuole membrane

229533:FGSG 09125
gene id: 229533:FGSG_09125
uniprot id: I1RXQ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07186
gene id: 229533:FGSG_07186
uniprot id: I1RSQ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

229533:FGSG 01196
gene id: 229533:FGSG_01196
uniprot id: I1RC93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 06340
gene id: 229533:FGSG_06340
uniprot id: I1RQJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

229533:FGSG 04913
gene id: 229533:FGSG_04913
uniprot id: I1RLU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 07450
gene id: 229533:FGSG_07450
uniprot id: I1RTE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

229533:FGSG 10397
gene id: 229533:FGSG_10397
uniprot id: I1S104
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the trichodiene synthase family.
messages: Expressed under trichothecene-inducing conditions.
messages: Leads to complete loss of culmorin production (PubMed:19880637). Does not affect the trichothecene biosynthetic pathway since 15-acetyldeoxynivalenol (15ADON) is still produced (PubMed:19880637). Keeps the ability to convert exogenously added longiborneol to culmorin (PubMed:19880637).
messages: Longiborneol synthase CLM1 is a potential target to reduce Fusarium head blight disease. 3D-structure modeling based on known 3D-structure of losely related enzymes has been used for screening of hypothetical inhibitors of CLM1 catalytic activity.
messages: Terpene cyclase involved in the biosynthesis of culmorin, a tricyclic sesquiterpene diol reported to have antifungal activity and some phytotoxicity to wheat coleoptile tissue, contributing to Fusarium head blight disease (PubMed:19880637) (Probable). The terpene cyclase CLM1 is responsible for the cyclization of farnesyl diphosphate into the intermediate longiborneol (PubMed:19880637). Longiborneol is then hydroxylated in a regio- and endo-stereoselective manner at position C-11 by the cytochrome P450 monooxygenase CLM2 to produce culmorin (PubMed:26673640). Additional non-specific oxygenases are also able to hydroxylate longiborneol at other sites than C-11 leading to 3-hydroxylongiborneol, 5-hydroxylongiborneol, 12-hydroxylongiborneol and 15-hydroxylongiborneol (PubMed:26673640). Moreover, another oxygenase capable of installing a C-11 exo-hydroxy group in longiborneol can also yield 11-epi-acetylculmorin (PubMed:26673640). The production of these longiborneol derivatives is dwarfed by the high abundance of culmorin, suggesting that CLM2 displays superior enzymatic activity to the unidentified, possibly promiscuous, additional oxygenases (PubMed:26673640).

229533:FGSG 05036
gene id: 229533:FGSG_05036
uniprot id: I1RM55
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

229533:FGSG 06073
gene id: 229533:FGSG_06073
uniprot id: I1RPU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 02770
gene id: 229533:FGSG_02770
uniprot id: I1RGB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

229533:FGSG 06388
gene id: 229533:FGSG_06388
uniprot id: I1RQP1
names: Similarity
messages: Belongs to the actin family.

229533:FGSG 05162
gene id: 229533:FGSG_05162
uniprot id: I1RMH2
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 00613
gene id: 229533:FGSG_00613
uniprot id: I1RAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

229533:FGSG 07172
gene id: 229533:FGSG_07172
uniprot id: I1RSP4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

229533:FGSG 05502
gene id: 229533:FGSG_05502
uniprot id: I1RNC9
names: Similarity
messages: Belongs to the KRI1 family.

229533:FGSG 01669
gene id: 229533:FGSG_01669
uniprot id: I1RDH3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07086
gene id: 229533:FGSG_07086
uniprot id: I1RSG8
names: Similarity
messages: Belongs to the RRN3 family.

229533:FGSG 04254
gene id: 229533:FGSG_04254
uniprot id: A0A1I9FFX3
uniprot id: Q4IEV4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-316 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
messages: Chromosome
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

229533:FGSG 11605
gene id: 229533:FGSG_11605
uniprot id: I1S446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 02058
gene id: 229533:FGSG_02058
uniprot id: I1REG9
names: Similarity
messages: Belongs to the peptidase S14 family.

229533:FGSG 02346
gene id: 229533:FGSG_02346
uniprot id: I1RF79
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:21436218). Catalyzes the reduction of the C14=C15 double bond within 4,4,24-trimethyl ergosta-8,14,24(28)-trienolto produce 4,4-dimethylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a sc…
messages: Endoplasmic reticulum membrane
messages: Exhibits significantly increased sensitivity to amine fungicides, including tridemorph, fenpropidin and spiroxamine, but not to non-amine fungicides.
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.

229533:FGSG 09166
gene id: 229533:FGSG_09166
uniprot id: I1RXU0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05847
gene id: 229533:FGSG_05847
uniprot id: I1RP90
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 01150
gene id: 229533:FGSG_01150
uniprot id: I1RC47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 02761
gene id: 229533:FGSG_02761
uniprot id: I1RGA3
names: Similarity
messages: Belongs to the Tim44 family.

229533:FGSG 03512
gene id: 229533:FGSG_03512
uniprot id: V6R645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02666
gene id: 229533:FGSG_02666
uniprot id: I1RG17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 07495
gene id: 229533:FGSG_07495
uniprot id: I1RTI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

229533:FGSG 12251
gene id: 229533:FGSG_12251
uniprot id: I1S5Y0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

229533:FGSG 06736
gene id: 229533:FGSG_06736
uniprot id: I1RRK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and FG06736.1.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. FG06736.1 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

229533:FGSG 10087
gene id: 229533:FGSG_10087
uniprot id: A0A1I9F466
uniprot id: Q4HY71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
messages: Associates with the nuclear pore complex.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
messages: Cytoplasm
messages: Nucleus membrane
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nuclear pore complex

229533:FGSG 11257
gene id: 229533:FGSG_11257
uniprot id: I1S386
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

229533:FGSG 09497
gene id: 229533:FGSG_09497
uniprot id: I1RYN9
names: Similarity
messages: Belongs to the SH3YL1 family.

229533:FGSG 03774
gene id: 229533:FGSG_03774
uniprot id: I1RIX7
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

229533:FGSG 02766
gene id: 229533:FGSG_02766
uniprot id: I1RGA8
names: Similarity
messages: Belongs to the UPF0507 family.

229533:FGSG 08377
gene id: 229533:FGSG_08377
uniprot id: I1RVT4
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 06681
gene id: 229533:FGSG_06681
uniprot id: I1RRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

229533:FGSG 02690
gene id: 229533:FGSG_02690
uniprot id: I1RG41
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 09580
gene id: 229533:FGSG_09580
uniprot id: I1RYW9
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

229533:FGSG 08133
gene id: 229533:FGSG_08133
uniprot id: I1RV69
names: Function
names: Similarity
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

229533:FGSG 01283
gene id: 229533:FGSG_01283
uniprot id: I1RCG9
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

229533:FGSG 01535
gene id: 229533:FGSG_01535
uniprot id: I1RD46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

229533:FGSG 11469
gene id: 229533:FGSG_11469
uniprot id: I1S3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

229533:FGSG 05255
gene id: 229533:FGSG_05255
uniprot id: I1RMR0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00195
gene id: 229533:FGSG_00195
uniprot id: I1R9P2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07134
gene id: 229533:FGSG_07134
uniprot id: I1RSL1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01447
gene id: 229533:FGSG_01447
uniprot id: I1RCW4
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

229533:FGSG 06110
gene id: 229533:FGSG_06110
uniprot id: I1RPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 00685
gene id: 229533:FGSG_00685
uniprot id: I1RAY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09275
gene id: 229533:FGSG_09275
uniprot id: V6RNM4
names: Similarity
messages: Belongs to the CNOT9 family.

229533:FGSG 10053
gene id: 229533:FGSG_10053
uniprot id: I1S039
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Blocks autophagy (PubMed:28894236). Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation and completely fails to form any perithecia (PubMed:28894236).
messages: Conjugated to ATG12; which is essential for autophagy (By similarity). Conjugation with ATG12 involves ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme (By similarity).
messages: Conjugated with ATG12 (By similarity). The ATG5-ATG12 conjugate forms a complex with several units of ATG16 (By similarity). The ATG12-ATG5 conjugate associates also with ATG3 (By similarity).
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) (By similarity). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production (By similarity). Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity). The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Preautophagosomal structure membrane

229533:FGSG 10198
gene id: 229533:FGSG_10198
uniprot id: I1S0H0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

229533:FGSG 07351
gene id: 229533:FGSG_07351
uniprot id: I1RT54
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

229533:FGSG 09701
gene id: 229533:FGSG_09701
uniprot id: I1RZ75
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11542
gene id: 229533:FGSG_11542
uniprot id: V6R1D2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 01561
gene id: 229533:FGSG_01561
uniprot id: I1RD72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

229533:FGSG 01162
gene id: 229533:FGSG_01162
uniprot id: I1RC59
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06139
gene id: 229533:FGSG_06139
uniprot id: I1RQ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

229533:FGSG 12187
gene id: 229533:FGSG_12187
uniprot id: I1S5R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

229533:FGSG 00952
gene id: 229533:FGSG_00952
uniprot id: I1RBM4
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.

229533:FGSG 03731
gene id: 229533:FGSG_03731
uniprot id: I1RIT7
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 10027
gene id: 229533:FGSG_10027
uniprot id: I1S015
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00261
gene id: 229533:FGSG_00261
uniprot id: I1R9U9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 04459
gene id: 229533:FGSG_04459
uniprot id: I1RKP6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07466
gene id: 229533:FGSG_07466
uniprot id: I1RTG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

229533:FGSG 03624
gene id: 229533:FGSG_03624
uniprot id: A0A1I9FAY2
uniprot id: I1RII8
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.
messages: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops. Induces cell death and hydrogen peroxide accumulation in infected wheat leaves.
messages: Expression is under the control of transcription factor XYR1 and highly induced during wheat infection and by xylan.
messages: Inhibited by the proteinaceous endoxylanase inhibitor I from T.aestivum (TAXI-I).
messages: Leads to about 40 percent reduction of xylanase activity when grown in culture with xylan as carbon source.
messages: Secreted

229533:FGSG 09100
gene id: 229533:FGSG_09100
uniprot id: I1RXM6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

229533:FGSG 07350
gene id: 229533:FGSG_07350
uniprot id: I1RT53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03919
gene id: 229533:FGSG_03919
uniprot id: I1RJB0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00967
gene id: 229533:FGSG_00967
uniprot id: I1RBN6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05546
gene id: 229533:FGSG_05546
uniprot id: I1RNG7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 01551
gene id: 229533:FGSG_01551
uniprot id: I1RD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

229533:FGSG 00656
gene id: 229533:FGSG_00656
uniprot id: I1RAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

229533:FGSG 09169
gene id: 229533:FGSG_09169
uniprot id: I1RXU3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00989
gene id: 229533:FGSG_00989
uniprot id: I1RBQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 4 family.
messages: Secreted

229533:FGSG 01053
gene id: 229533:FGSG_01053
uniprot id: I1RBW2
names: Similarity
messages: Belongs to the pyridoxine kinase family.

229533:FGSG 05438
gene id: 229533:FGSG_05438
uniprot id: I1RN72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

229533:FGSG 13861
gene id: 229533:FGSG_13861
uniprot id: I1SAI0
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Secreted

229533:FGSG 08299
gene id: 229533:FGSG_08299
uniprot id: I1RVL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

229533:FGSG 09300
gene id: 229533:FGSG_09300
uniprot id: I1RY63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

229533:FGSG 04864
gene id: 229533:FGSG_04864
uniprot id: I1RLQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

229533:FGSG 09061
gene id: 229533:FGSG_09061
uniprot id: I1RXJ0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

229533:FGSG 05244
gene id: 229533:FGSG_05244
uniprot id: I1RMQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

229533:FGSG 01375
gene id: 229533:FGSG_01375
uniprot id: I1RCQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
messages: Mitochondrion inner membrane

229533:FGSG 02640
gene id: 229533:FGSG_02640
uniprot id: I1RFZ3
names: Similarity
messages: Belongs to the peptidase C19 family.

229533:FGSG 00281
gene id: 229533:FGSG_00281
uniprot id: I1R9W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

229533:FGSG 01817
gene id: 229533:FGSG_01817
uniprot id: I1RDV0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02970
gene id: 229533:FGSG_02970
uniprot id: I1RGU3
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

229533:FGSG 08116
gene id: 229533:FGSG_08116
uniprot id: I1RV54
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 07918
gene id: 229533:FGSG_07918
uniprot id: I1RUL9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

229533:FGSG 10403
gene id: 229533:FGSG_10403
uniprot id: I1S110
names: Similarity
messages: Belongs to the SDHAF4 family.

229533:FGSG 04408
gene id: 229533:FGSG_04408
uniprot id: I1RKJ8
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.

229533:FGSG 05035
gene id: 229533:FGSG_05035
uniprot id: I1RM54
names: Similarity
messages: Belongs to the PdxS/SNZ family.

229533:FGSG 01021
gene id: 229533:FGSG_01021
uniprot id: I1RBT1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

229533:FGSG 08350
gene id: 229533:FGSG_08350
uniprot id: V6RK96
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

229533:FGSG 05298
gene id: 229533:FGSG_05298
uniprot id: I1RMU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

229533:FGSG 05049
gene id: 229533:FGSG_05049
uniprot id: I1RM67
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

229533:FGSG 00559
gene id: 229533:FGSG_00559
uniprot id: I1RAM7
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 13231
gene id: 229533:FGSG_13231
uniprot id: I1S8Q3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).
messages: Preautophagosomal structure membrane
messages: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
messages: The GRAM and PH domains are required for the localization of ATG26 to the preautophagosomal structure (PAS) and are involved in autophagy (By similarity).

229533:FGSG 07798
gene id: 229533:FGSG_07798
uniprot id: I1RUB2
names: Similarity
messages: In the C-terminal section; belongs to the NRP synthetase family.

229533:FGSG 12244
gene id: 229533:FGSG_12244
uniprot id: I1S5X3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06385
gene id: 229533:FGSG_06385
uniprot id: I1RQN9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

229533:FGSG 08446
gene id: 229533:FGSG_08446
uniprot id: A0A1I9F6J6
uniprot id: Q4I2W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

229533:FGSG 04141
gene id: 229533:FGSG_04141
uniprot id: I1RJV8
names: Function
names: Similarity
messages: Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
messages: Belongs to the rad9 family.

229533:FGSG 01573
gene id: 229533:FGSG_01573
uniprot id: I1RD81
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 02982
gene id: 229533:FGSG_02982
uniprot id: I1RGV3
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 05138
gene id: 229533:FGSG_05138
uniprot id: I1RME9
names: Similarity
messages: Belongs to the RRM CWC2 family.

229533:FGSG 02782
gene id: 229533:FGSG_02782
uniprot id: I1RGC3
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

229533:FGSG 01893
gene id: 229533:FGSG_01893
uniprot id: I1RE20
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

229533:FGSG 10239
gene id: 229533:FGSG_10239
uniprot id: I1S0K9
names: Similarity
messages: Belongs to the PP2C family.

229533:FGSG 09206
gene id: 229533:FGSG_09206
uniprot id: V6RMS3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

229533:FGSG 13370
gene id: 229533:FGSG_13370
uniprot id: A0A1I9F833
uniprot id: Q4I2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

229533:FGSG 00761
gene id: 229533:FGSG_00761
uniprot id: I1RB54
names: Similarity
messages: Belongs to the CDIP1/LITAF family.

229533:FGSG 04487
gene id: 229533:FGSG_04487
uniprot id: I1RKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02069
gene id: 229533:FGSG_02069
uniprot id: I1REI0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

229533:FGSG 08620
gene id: 229533:FGSG_08620
uniprot id: I1RWF4
names: Similarity
messages: Belongs to the cytochrome b5 family.

229533:FGSG 10374
gene id: 229533:FGSG_10374
uniprot id: I1S0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.
messages: Membrane

229533:FGSG 00376
gene id: 229533:FGSG_00376
uniprot id: I1RA52
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

229533:FGSG 00333
gene id: 229533:FGSG_00333
uniprot id: I1RA16
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08055
gene id: 229533:FGSG_08055
uniprot id: I1RUZ5
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 07090
gene id: 229533:FGSG_07090
uniprot id: I1RSH1
names: Similarity
messages: Belongs to the TMEM14 family.

229533:FGSG 00350
gene id: 229533:FGSG_00350
uniprot id: A0A1I9EV29
uniprot id: Q4IR08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

229533:FGSG 09598
gene id: 229533:FGSG_09598
uniprot id: I1RYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 07191
gene id: 229533:FGSG_07191
uniprot id: I1RSR0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

229533:FGSG 06208
gene id: 229533:FGSG_06208
uniprot id: I1RQ69
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

229533:FGSG 09453
gene id: 229533:FGSG_09453
uniprot id: I1RYJ7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

229533:FGSG 01111
gene id: 229533:FGSG_01111
uniprot id: I1RC11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

229533:FGSG 08781
gene id: 229533:FGSG_08781
uniprot id: I1RWU6
names: Similarity
messages: Belongs to the ERT1/acuK family.

229533:FGSG 09760
gene id: 229533:FGSG_09760
uniprot id: I1RZC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00970
gene id: 229533:FGSG_00970
uniprot id: I1RBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

229533:FGSG 03390
gene id: 229533:FGSG_03390
uniprot id: I1RHX4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04247
gene id: 229533:FGSG_04247
uniprot id: V6RAG6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 10661
gene id: 229533:FGSG_10661
uniprot id: V6RTS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02323
gene id: 229533:FGSG_02323
uniprot id: I1RF57
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription facto aurR1/GIP2 (PubMed:16461721).
messages: Nucleus
messages: Transcription factor that may participate in the regulation of the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:16879655, PubMed:16461721).

229533:FGSG 08392
gene id: 229533:FGSG_08392
uniprot id: I1RVU7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00458
gene id: 229533:FGSG_00458
uniprot id: I1RAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

229533:FGSG 00902
gene id: 229533:FGSG_00902
uniprot id: V6QWX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

229533:FGSG 13136
gene id: 229533:FGSG_13136
uniprot id: I1S8F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

229533:FGSG 00551
gene id: 229533:FGSG_00551
uniprot id: I1RAL9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

229533:FGSG 04468
gene id: 229533:FGSG_04468
uniprot id: I1RKQ3
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 03842
gene id: 229533:FGSG_03842
uniprot id: I1RJ42
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

229533:FGSG 10990
gene id: 229533:FGSG_10990
uniprot id: I1S2J4
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). Expression is also up-regulated during infection of barley (PubMed:21585270). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Leads to reduced virulence.
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. NRPS9 has a reduced A-T architecture.
messages: Nonribosomal peptide synthetase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).

229533:FGSG 02890
gene id: 229533:FGSG_02890
uniprot id: I1RGL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 03999
gene id: 229533:FGSG_03999
uniprot id: I1RJH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 01955
gene id: 229533:FGSG_01955
uniprot id: I1RE76
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

229533:FGSG 02506
gene id: 229533:FGSG_02506
uniprot id: I1RFM6
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

229533:FGSG 09632
gene id: 229533:FGSG_09632
uniprot id: I1RZ14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 01629
gene id: 229533:FGSG_01629
uniprot id: I1RDD3
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 05105
gene id: 229533:FGSG_05105
uniprot id: I1RMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

229533:FGSG 05547
gene id: 229533:FGSG_05547
uniprot id: I1RNG8
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Blocks autophagy (PubMed:28894236). Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation and completely fails to form any perithecia (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).
messages: Cytoplasm
messages: Homodimer (By similarity). Dimerization requires the presence of ATG13 (By similarity). Forms a ternary complex with ATG13 and ATG17 (By similarity).
messages: Preautophagosomal structure membrane
messages: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes (By similarity). Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates (By similarity). Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: The C-terminal region of ATG1 responsible for ATG13-binding comprises six alpha-helices which fold into two antiparallel three-helix bundles resembling each other (By similarity).
messages: The LIR motif is required for the interaction with ATG8 and for the association of ATG1 with autophagosomes (By similarity).

229533:FGSG 01865
gene id: 229533:FGSG_01865
uniprot id: I1RDZ5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

229533:FGSG 06923
gene id: 229533:FGSG_06923
uniprot id: Q4I785
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
messages: Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
messages: Endoplasmic reticulum membrane

229533:FGSG 04334
gene id: 229533:FGSG_04334
uniprot id: I1RKD4
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

229533:FGSG 08253
gene id: 229533:FGSG_08253
uniprot id: I1RVH7
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

229533:FGSG 03020
gene id: 229533:FGSG_03020
uniprot id: V6R8J3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01469
gene id: 229533:FGSG_01469
uniprot id: I1RCY4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 06278
gene id: 229533:FGSG_06278
uniprot id: I1RQD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

229533:FGSG 09374
gene id: 229533:FGSG_09374
uniprot id: I1RYC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

229533:FGSG 00137
gene id: 229533:FGSG_00137
uniprot id: I1R9J5
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 00597
gene id: 229533:FGSG_00597
uniprot id: I1RAR2
names: Similarity
messages: Belongs to the TFIIB family.

229533:FGSG 06281
gene id: 229533:FGSG_06281
uniprot id: I1RQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Mitochondrion matrix

229533:FGSG 04104
gene id: 229533:FGSG_04104
uniprot id: I1RJS2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

229533:FGSG 03213
gene id: 229533:FGSG_03213
uniprot id: I1RHG1
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 01798
gene id: 229533:FGSG_01798
uniprot id: I1RDT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

229533:FGSG 07370
gene id: 229533:FGSG_07370
uniprot id: I1RT71
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

229533:FGSG 06277
gene id: 229533:FGSG_06277
uniprot id: I1RQD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

229533:FGSG 07114
gene id: 229533:FGSG_07114
uniprot id: I1RSJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

229533:FGSG 08187
gene id: 229533:FGSG_08187
uniprot id: I1RVC0
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08919
gene id: 229533:FGSG_08919
uniprot id: I1RX69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

229533:FGSG 11411
gene id: 229533:FGSG_11411
uniprot id: I1S3M2
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 04570
gene id: 229533:FGSG_04570
uniprot id: I1RKZ7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 04953
gene id: 229533:FGSG_04953
uniprot id: I1RLY2
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 02720
gene id: 229533:FGSG_02720
uniprot id: I1RG69
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

229533:FGSG 07222
gene id: 229533:FGSG_07222
uniprot id: I1RST8
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 12397
gene id: 229533:FGSG_12397
uniprot id: I1S6C6
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 01046
gene id: 229533:FGSG_01046
uniprot id: I1RBV5
names: Similarity
messages: Belongs to the cullin family.

229533:FGSG 01066
gene id: 229533:FGSG_01066
uniprot id: I1RBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

229533:FGSG 08177
gene id: 229533:FGSG_08177
uniprot id: V6RTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10534
gene id: 229533:FGSG_10534
uniprot id: I1S1D4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 11428
gene id: 229533:FGSG_11428
uniprot id: I1S3N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family.
messages: Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
messages: Secreted

229533:FGSG 00257
gene id: 229533:FGSG_00257
uniprot id: I1R9U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

229533:FGSG 12094
gene id: 229533:FGSG_12094
uniprot id: I1S5H3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06677
gene id: 229533:FGSG_06677
uniprot id: I1RRF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 07593
gene id: 229533:FGSG_07593
uniprot id: I1RTS7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

229533:FGSG 01348
gene id: 229533:FGSG_01348
uniprot id: I1RCM7
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

229533:FGSG 11806
gene id: 229533:FGSG_11806
uniprot id: I1S4N8
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

229533:FGSG 01591
gene id: 229533:FGSG_01591
uniprot id: I1RD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 01184
gene id: 229533:FGSG_01184
uniprot id: I1RC81
names: Similarity
messages: Belongs to the RNR ribonuclease family.

229533:FGSG 07568
gene id: 229533:FGSG_07568
uniprot id: I1RTQ4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00537
gene id: 229533:FGSG_00537
uniprot id: I1RAK6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08477
gene id: 229533:FGSG_08477
uniprot id: I1RW24
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

229533:FGSG 06708
gene id: 229533:FGSG_06708
uniprot id: I1RRI5
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

229533:FGSG 04588
gene id: 229533:FGSG_04588
uniprot id: I1RL11
names: Biotechnology
names: Domain
names: Function
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; a methyltransferase (CMeT) domain responsible for methylations; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.
messages: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 05188
gene id: 229533:FGSG_05188
uniprot id: I1RMJ8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06511
gene id: 229533:FGSG_06511
uniprot id: I1RR08
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

229533:FGSG 05387
gene id: 229533:FGSG_05387
uniprot id: I1RN26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

229533:FGSG 03508
gene id: 229533:FGSG_03508
uniprot id: I1RI81
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07393
gene id: 229533:FGSG_07393
uniprot id: A0A1I9FP77
uniprot id: Q4I5W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
messages: centromere

229533:FGSG 06776
gene id: 229533:FGSG_06776
uniprot id: I1RRP3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

229533:FGSG 06289
gene id: 229533:FGSG_06289
uniprot id: I1RQE7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

229533:FGSG 03609
gene id: 229533:FGSG_03609
uniprot id: I1RIH6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 02717
gene id: 229533:FGSG_02717
uniprot id: I1RG66
names: Similarity
messages: Belongs to the IlvD/Edd family.

229533:FGSG 04678
gene id: 229533:FGSG_04678
uniprot id: I1RL92
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 02015
gene id: 229533:FGSG_02015
uniprot id: I1REC8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 09547
gene id: 229533:FGSG_09547
uniprot id: I1RYT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane

229533:FGSG 08634
gene id: 229533:FGSG_08634
uniprot id: I1RWG5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02229
gene id: 229533:FGSG_02229
uniprot id: I1REX1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11686
gene id: 229533:FGSG_11686
uniprot id: I1S4B9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00358
gene id: 229533:FGSG_00358
uniprot id: I1RA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

229533:FGSG 10304
gene id: 229533:FGSG_10304
uniprot id: I1S0R7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

229533:FGSG 01690
gene id: 229533:FGSG_01690
uniprot id: I1RDJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cytoskeleton

229533:FGSG 01036
gene id: 229533:FGSG_01036
uniprot id: I1RBU6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09279
gene id: 229533:FGSG_09279
uniprot id: I1RY46
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 07884
gene id: 229533:FGSG_07884
uniprot id: I1RUJ0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02495
gene id: 229533:FGSG_02495
uniprot id: I1RFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

229533:FGSG 05702
gene id: 229533:FGSG_05702
uniprot id: I1RNW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.
messages: Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.

229533:FGSG 08807
gene id: 229533:FGSG_08807
uniprot id: I1RWX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: May form a complex with LTO1.
messages: Nucleus
messages: The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.

229533:FGSG 05608
gene id: 229533:FGSG_05608
uniprot id: I1RNM5
names: Similarity
messages: Belongs to the palC family.

229533:FGSG 11850
gene id: 229533:FGSG_11850
uniprot id: I1S4T3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Plays a pivotal role in conidiation by regulating cell cycle pathways and other conidiation-related genes (PubMed:24039821).
messages: Belongs to the TEC1 family.
messages: Expression is positively regulated by flbD (PubMed:25277408).
messages: Leads to abnormally shaped phialides and abolishes production of conidia (PubMed:24039821).
messages: Nucleus

229533:FGSG 09323
gene id: 229533:FGSG_09323
uniprot id: I1RY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 11228
gene id: 229533:FGSG_11228
uniprot id: I1S360
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 11842
gene id: 229533:FGSG_11842
uniprot id: I1S4S4
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.

229533:FGSG 09847
gene id: 229533:FGSG_09847
uniprot id: I1RZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

229533:FGSG 05090
gene id: 229533:FGSG_05090
uniprot id: A0A1I9FSD9
uniprot id: Q4ICG8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

229533:FGSG 07838
gene id: 229533:FGSG_07838
uniprot id: I1RUE8
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 00043
gene id: 229533:FGSG_00043
uniprot id: I1R9B0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 06108
gene id: 229533:FGSG_06108
uniprot id: I1RPX6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10606
gene id: 229533:FGSG_10606
uniprot id: A0A1I9F616
uniprot id: Q4HWQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

229533:FGSG 08333
gene id: 229533:FGSG_08333
uniprot id: Q4I375
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
messages: Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity).

229533:FGSG 09878
gene id: 229533:FGSG_09878
uniprot id: I1RZM8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

229533:FGSG 10836
gene id: 229533:FGSG_10836
uniprot id: I1S252
names: Similarity
messages: Belongs to the PIGH family.

229533:FGSG 07043
gene id: 229533:FGSG_07043
uniprot id: I1RSC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

229533:FGSG 11029
gene id: 229533:FGSG_11029
uniprot id: I1S2N0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12485
gene id: 229533:FGSG_12485
uniprot id: I1S6L3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09748
gene id: 229533:FGSG_09748
uniprot id: I1RZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

229533:FGSG 06078
gene id: 229533:FGSG_06078
uniprot id: I1RPU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

229533:FGSG 04829
gene id: 229533:FGSG_04829
uniprot id: I1RLM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 09998
gene id: 229533:FGSG_09998
uniprot id: I1RZY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

229533:FGSG 12584
gene id: 229533:FGSG_12584
uniprot id: I1S6W1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01157
gene id: 229533:FGSG_01157
uniprot id: I1RC54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

229533:FGSG 04237
gene id: 229533:FGSG_04237
uniprot id: I1RK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

229533:FGSG 00834
gene id: 229533:FGSG_00834
uniprot id: I1RBC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

229533:FGSG 08464
gene id: 229533:FGSG_08464
uniprot id: I1RW12
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 09704
gene id: 229533:FGSG_09704
uniprot id: I1RZ78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

229533:FGSG 06941
gene id: 229533:FGSG_06941
uniprot id: I1RS34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

229533:FGSG 07325
gene id: 229533:FGSG_07325
uniprot id: I1RT32
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09335
gene id: 229533:FGSG_09335
uniprot id: I1RY94
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03017
gene id: 229533:FGSG_03017
uniprot id: I1RGY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

229533:FGSG 05827
gene id: 229533:FGSG_05827
uniprot id: I1RP73
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05433
gene id: 229533:FGSG_05433
uniprot id: I1RN67
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

229533:FGSG 09819
gene id: 229533:FGSG_09819
uniprot id: I1RZH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 04265
gene id: 229533:FGSG_04265
uniprot id: I1RK72
names: Similarity
messages: Belongs to the CWC26 family.

229533:FGSG 10747
gene id: 229533:FGSG_10747
uniprot id: V6RU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01175
gene id: 229533:FGSG_01175
uniprot id: I1RC72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

229533:FGSG 01861
gene id: 229533:FGSG_01861
uniprot id: I1RDZ2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04212
gene id: 229533:FGSG_04212
uniprot id: I1RK24
names: Similarity
messages: Belongs to the GST superfamily. Omega family.

229533:FGSG 03144
gene id: 229533:FGSG_03144
uniprot id: I1RH99
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

229533:FGSG 11079
gene id: 229533:FGSG_11079
uniprot id: I1S2S6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11049
gene id: 229533:FGSG_11049
uniprot id: I1S2P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family.
messages: Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
messages: Secreted

229533:FGSG 01685
gene id: 229533:FGSG_01685
uniprot id: I1RDI6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

229533:FGSG 11291
gene id: 229533:FGSG_11291
uniprot id: I1S3B5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

229533:FGSG 09401
gene id: 229533:FGSG_09401
uniprot id: I1RYF2
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 02944
gene id: 229533:FGSG_02944
uniprot id: I1RGS0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 12342
gene id: 229533:FGSG_12342
uniprot id: I1S671
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 00176
gene id: 229533:FGSG_00176
uniprot id: I1R9M7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

229533:FGSG 06579
gene id: 229533:FGSG_06579
uniprot id: I1RR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 05388
gene id: 229533:FGSG_05388
uniprot id: I1RN27
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07034
gene id: 229533:FGSG_07034
uniprot id: I1RSC0
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

229533:FGSG 06958
gene id: 229533:FGSG_06958
uniprot id: I1RS49
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

229533:FGSG 09968
gene id: 229533:FGSG_09968
uniprot id: I1RZW2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06376
gene id: 229533:FGSG_06376
uniprot id: I1RQN0
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

229533:FGSG 06581
gene id: 229533:FGSG_06581
uniprot id: A0A1I9FF31
uniprot id: Q4I877
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Required for nuclear migration.
messages: Self-associates. Interacts with PAC1 (By similarity).
messages: cytoskeleton

229533:FGSG 11037
gene id: 229533:FGSG_11037
uniprot id: I1S2N7
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

229533:FGSG 13118
gene id: 229533:FGSG_13118
uniprot id: I1S8E0
names: Similarity
messages: Belongs to the WD repeat coronin family.

229533:FGSG 00107
gene id: 229533:FGSG_00107
uniprot id: I1R9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00217
gene id: 229533:FGSG_00217
uniprot id: I1R9R2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 13956
gene id: 229533:FGSG_13956
uniprot id: I1SAS5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

229533:FGSG 07643
gene id: 229533:FGSG_07643
uniprot id: I1RTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 07062
gene id: 229533:FGSG_07062
uniprot id: I1RSE4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09363
gene id: 229533:FGSG_09363
uniprot id: I1RYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

229533:FGSG 09872
gene id: 229533:FGSG_09872
uniprot id: I1RZM3
names: Similarity
messages: Belongs to the isochorismatase family.

229533:FGSG 02339
gene id: 229533:FGSG_02339
uniprot id: I1RF73
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

229533:FGSG 00841
gene id: 229533:FGSG_00841
uniprot id: I1RBC5
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

229533:FGSG 04217
gene id: 229533:FGSG_04217
uniprot id: I1RK29
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00768
gene id: 229533:FGSG_00768
uniprot id: I1RB61
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10226
gene id: 229533:FGSG_10226
uniprot id: I1S0J7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy (By similarity). Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine (By similarity). Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Homodimer (By similarity). Interacts with ATG8 through a thioester bond between Cys-550 and the C-terminal 'Gly-116' of ATG8 and with ATG12 through a thioester bond between Cys-550 and the C-terminal 'Gly-160' of ATG12 (By similarity). Interacts also with ATG3 (By similarity).
messages: Preautophagosomal structure
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Strongly reduces the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: The C-terminal residues 650 to 689 are required for homodimerization, as well as the interactions with ATG3, ATG8 and ATG12; and the C-terminal 17 residues are required for the ATG8 lipidation (By similarity).
messages: The GxGxxG motif is important for the function, possibly through binding with ATP (By similarity).

229533:FGSG 07055
gene id: 229533:FGSG_07055
uniprot id: I1RSD8
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 10480
gene id: 229533:FGSG_10480
uniprot id: I1S181
names: Similarity
messages: Belongs to the OBAP family.

229533:FGSG 10570
gene id: 229533:FGSG_10570
uniprot id: I1S1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10925
gene id: 229533:FGSG_10925
uniprot id: I1S2D5
names: Similarity
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Monomer.

229533:FGSG 07412
gene id: 229533:FGSG_07412
uniprot id: I1RTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 06141
gene id: 229533:FGSG_06141
uniprot id: I1RQ08
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

229533:FGSG 05887
gene id: 229533:FGSG_05887
uniprot id: I1RPC5
names: Similarity
messages: Belongs to the APC13 family.

229533:FGSG 01015
gene id: 229533:FGSG_01015
uniprot id: I1RBS5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

229533:FGSG 02455
gene id: 229533:FGSG_02455
uniprot id: A0A1I9F267
uniprot id: Q4IK03
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cu(2+) or Zn(2+).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

229533:FGSG 03090
gene id: 229533:FGSG_03090
uniprot id: I1RH48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

229533:FGSG 06368
gene id: 229533:FGSG_06368
uniprot id: I1RQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 09376
gene id: 229533:FGSG_09376
uniprot id: I1RYD1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08038
gene id: 229533:FGSG_08038
uniprot id: I1RUX9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04957
gene id: 229533:FGSG_04957
uniprot id: I1RLY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10175
gene id: 229533:FGSG_10175
uniprot id: I1S0F1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

229533:FGSG 04554
gene id: 229533:FGSG_04554
uniprot id: I1RKY2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

229533:FGSG 07471
gene id: 229533:FGSG_07471
uniprot id: I1RTG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

229533:FGSG 13041
gene id: 229533:FGSG_13041
uniprot id: I1S863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

229533:FGSG 12586
gene id: 229533:FGSG_12586
uniprot id: I1S6W3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 00070
gene id: 229533:FGSG_00070
uniprot id: I1R9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06549
gene id: 229533:FGSG_06549
uniprot id: I1RR40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 08380
gene id: 229533:FGSG_08380
uniprot id: I1RVT7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10474
gene id: 229533:FGSG_10474
uniprot id: I1S176
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 02602
gene id: 229533:FGSG_02602
uniprot id: I1RFW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Nucleus

229533:FGSG 02232
gene id: 229533:FGSG_02232
uniprot id: I1REX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

229533:FGSG 13457
gene id: 229533:FGSG_13457
uniprot id: I1S9C7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06518
gene id: 229533:FGSG_06518
uniprot id: V6RDX9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 05226
gene id: 229533:FGSG_05226
uniprot id: I1RMN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 12747
gene id: 229533:FGSG_12747
uniprot id: I1S7C4
names: Similarity
messages: Belongs to the PrpF family.

229533:FGSG 02729
gene id: 229533:FGSG_02729
uniprot id: Q4IJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Interacts with CHS3.

229533:FGSG 05329
gene id: 229533:FGSG_05329
uniprot id: Q4IBS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRO1 family.
messages: Cytoplasm
messages: Endosome
messages: Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.

229533:FGSG 08930
gene id: 229533:FGSG_08930
uniprot id: I1RX79
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08736
gene id: 229533:FGSG_08736
uniprot id: I1RWQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

229533:FGSG 05836
gene id: 229533:FGSG_05836
uniprot id: I1RP80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 11024
gene id: 229533:FGSG_11024
uniprot id: I1S2M5
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Results in increased sensitivity to tebuconazole, diniconazole, difenoconazole, flutriafol and prochloraz, but not to triadimefon and propiconazole (PubMed:20955812). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Reduces virulence on host wheat ears (PubMed:23442154). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).
messages: Endoplasmic reticulum membrane
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Together with cyp51A and cyp51B, encodes the sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:20955812). Cyp51C does not seem to encode an active sterol 14-alpha-demethylase, but can impact indirectly on sterol 14alpha-demethylation, and is required for full virulence on host wheat ears, but not on Arabidopsis floral tissue or the fruits of apple and tomato (PubMed:20955812, PubMed:23442154). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity).

229533:FGSG 09361
gene id: 229533:FGSG_09361
uniprot id: I1RYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

229533:FGSG 05493
gene id: 229533:FGSG_05493
uniprot id: I1RNC1
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

229533:FGSG 11494
gene id: 229533:FGSG_11494
uniprot id: I1S3U6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 03967
gene id: 229533:FGSG_03967
uniprot id: I1RJF1
names: Similarity
messages: Belongs to the peptidase M20A family.

229533:FGSG 11729
gene id: 229533:FGSG_11729
uniprot id: I1S4G2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

229533:FGSG 06697
gene id: 229533:FGSG_06697
uniprot id: I1RRH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

229533:FGSG 09912
gene id: 229533:FGSG_09912
uniprot id: I1RZR0
names: Similarity
messages: Belongs to the Cdt1 family.

229533:FGSG 11184
gene id: 229533:FGSG_11184
uniprot id: I1S323
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 09888
gene id: 229533:FGSG_09888
uniprot id: I1RZN8
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 12292
gene id: 229533:FGSG_12292
uniprot id: I1S621
names: Similarity
messages: Belongs to the Gfa family.

229533:FGSG 07164
gene id: 229533:FGSG_07164
uniprot id: I1RSN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

229533:FGSG 09782
gene id: 229533:FGSG_09782
uniprot id: I1RZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 05751
gene id: 229533:FGSG_05751
uniprot id: A0A1I9FQL5
uniprot id: Q4IAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Component of the SWR1 chromatin-remodeling complex.
messages: Nucleus

229533:FGSG 05723
gene id: 229533:FGSG_05723
uniprot id: I1RNX8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04863
gene id: 229533:FGSG_04863
uniprot id: I1RLP9
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 02636
gene id: 229533:FGSG_02636
uniprot id: I1RFZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
messages: Membrane

229533:FGSG 12296
gene id: 229533:FGSG_12296
uniprot id: I1S625
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
messages: Membrane

229533:FGSG 05267
gene id: 229533:FGSG_05267
uniprot id: I1RMS0
names: Similarity
messages: Belongs to the MTFP1 family.

229533:FGSG 02601
gene id: 229533:FGSG_02601
uniprot id: I1RFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

229533:FGSG 00777
gene id: 229533:FGSG_00777
uniprot id: I1RB70
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

229533:FGSG 09259
gene id: 229533:FGSG_09259
uniprot id: I1RY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

229533:FGSG 07802
gene id: 229533:FGSG_07802
uniprot id: I1RUB5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00864
gene id: 229533:FGSG_00864
uniprot id: V6QV38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

229533:FGSG 01505
gene id: 229533:FGSG_01505
uniprot id: I1RD18
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 05598
gene id: 229533:FGSG_05598
uniprot id: I1RNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

229533:FGSG 05829
gene id: 229533:FGSG_05829
uniprot id: I1RP75
names: Similarity
messages: Belongs to the peptidase S9C family.

229533:FGSG 04302
gene id: 229533:FGSG_04302
uniprot id: I1RKA5
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 04403
gene id: 229533:FGSG_04403
uniprot id: V6R283
names: Subcellular Location Annotation
messages: nucleolus

229533:FGSG 12900
gene id: 229533:FGSG_12900
uniprot id: I1S7S5
names: Similarity
messages: Belongs to the TRAPPC13 family.

229533:FGSG 00538
gene id: 229533:FGSG_00538
uniprot id: I1RAK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 11195
gene id: 229533:FGSG_11195
uniprot id: I1S333
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00870
gene id: 229533:FGSG_00870
uniprot id: I1RBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

229533:FGSG 05124
gene id: 229533:FGSG_05124
uniprot id: I1RMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP16 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

229533:FGSG 05503
gene id: 229533:FGSG_05503
uniprot id: I1RND0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10305
gene id: 229533:FGSG_10305
uniprot id: I1S0R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 04558
gene id: 229533:FGSG_04558
uniprot id: I1RKY6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

229533:FGSG 02066
gene id: 229533:FGSG_02066
uniprot id: I1REH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 08778
gene id: 229533:FGSG_08778
uniprot id: V6RRF6
names: Similarity
messages: Belongs to the peptidase A22B family.

229533:FGSG 10743
gene id: 229533:FGSG_10743
uniprot id: I1S1W8
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

229533:FGSG 04669
gene id: 229533:FGSG_04669
uniprot id: I1RL84
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family. UbiD-like/FDC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
messages: Cytoplasm
messages: Homodimer. May form higher order oligomers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 04747
gene id: 229533:FGSG_04747
uniprot id: I1RLF1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08678
gene id: 229533:FGSG_08678
uniprot id: I1RWK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

229533:FGSG 08712
gene id: 229533:FGSG_08712
uniprot id: V6RRM0
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

229533:FGSG 09600
gene id: 229533:FGSG_09600
uniprot id: I1RYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
messages: Component of the retromer complex.

229533:FGSG 05543
gene id: 229533:FGSG_05543
uniprot id: A0A1I9FXS9
uniprot id: Q4IB65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

229533:FGSG 11656
gene id: 229533:FGSG_11656
uniprot id: I1S489
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthase subunit beta; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

229533:FGSG 05284
gene id: 229533:FGSG_05284
uniprot id: I1RMT6
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

229533:FGSG 00409
gene id: 229533:FGSG_00409
uniprot id: I1RA82
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

229533:FGSG 02072
gene id: 229533:FGSG_02072
uniprot id: I1REI3
names: Similarity
messages: Belongs to the NAD kinase family.

229533:FGSG 11093
gene id: 229533:FGSG_11093
uniprot id: I1S2U0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 12355
gene id: 229533:FGSG_12355
uniprot id: I1S684
names: Similarity
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.

229533:FGSG 06935
gene id: 229533:FGSG_06935
uniprot id: I1RS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

229533:FGSG 02752
gene id: 229533:FGSG_02752
uniprot id: A0A1I9F369
uniprot id: Q4IJ56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 10919
gene id: 229533:FGSG_10919
uniprot id: I1S2D0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10713
gene id: 229533:FGSG_10713
uniprot id: I1S1U3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 10222
gene id: 229533:FGSG_10222
uniprot id: A0A1I9F4Y5
uniprot id: Q4HXT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Cell membrane
messages: Plays a role in the regulation of membrane potential. Could mediate a proton leak (By similarity).

229533:FGSG 03486
gene id: 229533:FGSG_03486
uniprot id: I1RI61
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

229533:FGSG 05682
gene id: 229533:FGSG_05682
uniprot id: I1RNU2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07347
gene id: 229533:FGSG_07347
uniprot id: I1RT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

229533:FGSG 07445
gene id: 229533:FGSG_07445
uniprot id: Q4I5R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

229533:FGSG 05390
gene id: 229533:FGSG_05390
uniprot id: A0A1I9FVT7
uniprot id: Q4IBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
messages: Mitochondrion

229533:FGSG 06548
gene id: 229533:FGSG_06548
uniprot id: I1RR39
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

229533:FGSG 09103
gene id: 229533:FGSG_09103
uniprot id: I1RXM9
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 07853
gene id: 229533:FGSG_07853
uniprot id: I1RUG0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

229533:FGSG 07087
gene id: 229533:FGSG_07087
uniprot id: I1RSG9
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

229533:FGSG 06185
gene id: 229533:FGSG_06185
uniprot id: I1RQ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: nuclear pore complex

229533:FGSG 09049
gene id: 229533:FGSG_09049
uniprot id: I1RXI0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 10629
gene id: 229533:FGSG_10629
uniprot id: I1S1M2
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08339
gene id: 229533:FGSG_08339
uniprot id: I1RVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

229533:FGSG 07956
gene id: 229533:FGSG_07956
uniprot id: I1RUQ5
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

229533:FGSG 05858
gene id: 229533:FGSG_05858
uniprot id: A0A1I9FU53
uniprot id: Q4IAA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 10639
gene id: 229533:FGSG_10639
uniprot id: I1S1N1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01386
gene id: 229533:FGSG_01386
uniprot id: V6QYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

229533:FGSG 01429
gene id: 229533:FGSG_01429
uniprot id: I1RCU7
names: Similarity
messages: Belongs to the nucleoporin interacting component (NIC) family.

229533:FGSG 06017
gene id: 229533:FGSG_06017
uniprot id: I1RPP1
names: Similarity
messages: Belongs to the Necrosis inducing protein (NPP1) family.

229533:FGSG 03121
gene id: 229533:FGSG_03121
uniprot id: I1RH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 01369
gene id: 229533:FGSG_01369
uniprot id: I1RCP5
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

229533:FGSG 05537
gene id: 229533:FGSG_05537
uniprot id: I1RNG1
names: Function
names: Similarity
messages: Belongs to the CDC123 family.
messages: Regulates the cell cycle in a nutrient dependent manner.

229533:FGSG 07223
gene id: 229533:FGSG_07223
uniprot id: I1RST9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 10845
gene id: 229533:FGSG_10845
uniprot id: I1S261
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

229533:FGSG 01640
gene id: 229533:FGSG_01640
uniprot id: I1RDE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

229533:FGSG 02641
gene id: 229533:FGSG_02641
uniprot id: V6R0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 10762
gene id: 229533:FGSG_10762
uniprot id: I1S1Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

229533:FGSG 06914
gene id: 229533:FGSG_06914
uniprot id: I1RS10
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

229533:FGSG 01346
gene id: 229533:FGSG_01346
uniprot id: I1RCM5
names: Similarity
messages: Belongs to the enolase family.

229533:FGSG 01164
gene id: 229533:FGSG_01164
uniprot id: I1RC61
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

229533:FGSG 07951
gene id: 229533:FGSG_07951
uniprot id: I1RUQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAM1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 09766
gene id: 229533:FGSG_09766
uniprot id: A0A1I9FKD0
uniprot id: Q4HZ42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 12519
gene id: 229533:FGSG_12519
uniprot id: I1S6P6
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

229533:FGSG 02499
gene id: 229533:FGSG_02499
uniprot id: I1RFL9
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 10264
gene id: 229533:FGSG_10264
uniprot id: V6RY56
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.

229533:FGSG 01265
gene id: 229533:FGSG_01265
uniprot id: V6R3U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Membrane

229533:FGSG 05665
gene id: 229533:FGSG_05665
uniprot id: I1RNS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

229533:FGSG 02531
gene id: 229533:FGSG_02531
uniprot id: I1RFP7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00634
gene id: 229533:FGSG_00634
uniprot id: I1RAU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

229533:FGSG 00439
gene id: 229533:FGSG_00439
uniprot id: I1RAB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

229533:FGSG 09333
gene id: 229533:FGSG_09333
uniprot id: A0A1I9FGR7
uniprot id: Q4I0C5
names: Function
names: Subcellular Location Annotation
messages: May act as a transcriptional repressor of multidrug resistance genes.
messages: Nucleus

229533:FGSG 06944
gene id: 229533:FGSG_06944
uniprot id: I1RS37
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 11399
gene id: 229533:FGSG_11399
uniprot id: I1S3L1
names: Function
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).

229533:FGSG 09155
gene id: 229533:FGSG_09155
uniprot id: I1RXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 03646
gene id: 229533:FGSG_03646
uniprot id: I1RIK9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05925
gene id: 229533:FGSG_05925
uniprot id: I1RPF6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03343
gene id: 229533:FGSG_03343
uniprot id: I1RHT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

229533:FGSG 00352
gene id: 229533:FGSG_00352
uniprot id: I1RA31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

229533:FGSG 06222
gene id: 229533:FGSG_06222
uniprot id: I1RQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 05052
gene id: 229533:FGSG_05052
uniprot id: I1RM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 10865
gene id: 229533:FGSG_10865
uniprot id: I1S279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

229533:FGSG 05769
gene id: 229533:FGSG_05769
uniprot id: I1RP20
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

229533:FGSG 09307
gene id: 229533:FGSG_09307
uniprot id: I1RY70
names: Function
names: Similarity
messages: Belongs to the KAR5 family.
messages: Required for nuclear membrane fusion during karyogamy.

229533:FGSG 04988
gene id: 229533:FGSG_04988
uniprot id: I1RM14
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

229533:FGSG 13444
gene id: 229533:FGSG_13444
uniprot id: I1S9B4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06157
gene id: 229533:FGSG_06157
uniprot id: I1RQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 03436
gene id: 229533:FGSG_03436
uniprot id: I1RI16
names: Similarity
messages: Belongs to the chloroperoxidase family.

229533:FGSG 08914
gene id: 229533:FGSG_08914
uniprot id: I1RX64
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10738
gene id: 229533:FGSG_10738
uniprot id: I1S1W4
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

229533:FGSG 09957
gene id: 229533:FGSG_09957
uniprot id: I1RZV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.

229533:FGSG 08996
gene id: 229533:FGSG_08996
uniprot id: I1RXD0
names: Similarity
messages: Belongs to the IF-3 family.

229533:FGSG 02426
gene id: 229533:FGSG_02426
uniprot id: I1RFF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

229533:FGSG 09041
gene id: 229533:FGSG_09041
uniprot id: I1RXH2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

229533:FGSG 06317
gene id: 229533:FGSG_06317
uniprot id: V6RKE4
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

229533:FGSG 01570
gene id: 229533:FGSG_01570
uniprot id: I1RD78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cutinase family.
messages: Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.
messages: Secreted

229533:FGSG 06225
gene id: 229533:FGSG_06225
uniprot id: I1RQ86
names: Similarity
messages: Belongs to the MT-A70-like family.

229533:FGSG 04225
gene id: 229533:FGSG_04225
uniprot id: I1RK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

229533:FGSG 02161
gene id: 229533:FGSG_02161
uniprot id: V6QYX4
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

229533:FGSG 01377
gene id: 229533:FGSG_01377
uniprot id: I1RCQ3
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

229533:FGSG 10537
gene id: 229533:FGSG_10537
uniprot id: I1S1D7
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

229533:FGSG 00496
gene id: 229533:FGSG_00496
uniprot id: I1RAG8
names: Similarity
messages: Belongs to the PPase family.

229533:FGSG 07113
gene id: 229533:FGSG_07113
uniprot id: I1RSJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

229533:FGSG 05411
gene id: 229533:FGSG_05411
uniprot id: I1RN48
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

229533:FGSG 01306
gene id: 229533:FGSG_01306
uniprot id: I1RCI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

229533:FGSG 01397
gene id: 229533:FGSG_01397
uniprot id: I1RCS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

229533:FGSG 03177
gene id: 229533:FGSG_03177
uniprot id: I1RHD1
names: Similarity
messages: Belongs to the amidase family.

229533:FGSG 00048
gene id: 229533:FGSG_00048
uniprot id: I1R9B5
names: Cofactor
names: Function
names: Similarity
messages: 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.
messages: Binds 1 Fe(2+) ion per subunit.

229533:FGSG 01394
gene id: 229533:FGSG_01394
uniprot id: I1RCR8
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

229533:FGSG 00012
gene id: 229533:FGSG_00012
uniprot id: I1R984
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 08694
gene id: 229533:FGSG_08694
uniprot id: V6RK56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Mitochondrion membrane

229533:FGSG 01939
gene id: 229533:FGSG_01939
uniprot id: I1RE63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.

229533:FGSG 00529
gene id: 229533:FGSG_00529
uniprot id: V6QVL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 01642
gene id: 229533:FGSG_01642
uniprot id: I1RDE6
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

229533:FGSG 10888
gene id: 229533:FGSG_10888
uniprot id: I1S2A2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11326
gene id: 229533:FGSG_11326
uniprot id: V6RUY9
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

229533:FGSG 04996
gene id: 229533:FGSG_04996
uniprot id: I1RM21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.
messages: Nucleus
messages: Polynucleotide 5'-kinase involved in rRNA processing.
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

229533:FGSG 04571
gene id: 229533:FGSG_04571
uniprot id: I1RKZ8
names: Similarity
messages: Belongs to the cytidylyltransferase family.

229533:FGSG 07421
gene id: 229533:FGSG_07421
uniprot id: I1RTC0
names: Similarity
messages: Belongs to the aspartokinase family.

229533:FGSG 04311
gene id: 229533:FGSG_04311
uniprot id: I1RKB4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07440
gene id: 229533:FGSG_07440
uniprot id: I1RTD7
names: Similarity
messages: Belongs to the TRM112 family.

229533:FGSG 09988
gene id: 229533:FGSG_09988
uniprot id: I1RZX9
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

229533:FGSG 07375
gene id: 229533:FGSG_07375
uniprot id: I1RT76
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

229533:FGSG 05556
gene id: 229533:FGSG_05556
uniprot id: I1RNH6
names: Similarity
messages: Belongs to the SAS10 family.

229533:FGSG 09557
gene id: 229533:FGSG_09557
uniprot id: A0A1I9FL55
uniprot id: Q4HZQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.

229533:FGSG 09713
gene id: 229533:FGSG_09713
uniprot id: A0A1I9FS24
uniprot id: Q4HZ95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 06325
gene id: 229533:FGSG_06325
uniprot id: I1RQI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 01352
gene id: 229533:FGSG_01352
uniprot id: I1RCN1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 13878
gene id: 229533:FGSG_13878
uniprot id: I1SAJ7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. NRPS5 has the following 7 module architecture: A-C-A-T-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-TE.
messages: Nonribosomal peptide synthetase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
messages: Produces significantly smaller lesions on susceptible wheat cultivars.

229533:FGSG 07192
gene id: 229533:FGSG_07192
uniprot id: I1RSR1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06473
gene id: 229533:FGSG_06473
uniprot id: I1RQX2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02136
gene id: 229533:FGSG_02136
uniprot id: I1REP2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00724
gene id: 229533:FGSG_00724
uniprot id: I1RB20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

229533:FGSG 10979
gene id: 229533:FGSG_10979
uniprot id: I1S2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

229533:FGSG 11011
gene id: 229533:FGSG_11011
uniprot id: I1S2L3
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 00059
gene id: 229533:FGSG_00059
uniprot id: I1R9C5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10995
gene id: 229533:FGSG_10995
uniprot id: I1S2J9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: ABC transporter; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).
messages: Leads to reduced virulence (PubMed:23266949, PubMed:30804501). Results in a substantial increase of fusaoctaxin A, and abolishes the production of fusapentaxin A and fusatrixin A (PubMed:31100892).

229533:FGSG 01002
gene id: 229533:FGSG_01002
uniprot id: I1RBR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

229533:FGSG 10223
gene id: 229533:FGSG_10223
uniprot id: A0A1I9F3V3
uniprot id: Q4HXT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 01138
gene id: 229533:FGSG_01138
uniprot id: I1RC36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

229533:FGSG 02493
gene id: 229533:FGSG_02493
uniprot id: I1RFL4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

229533:FGSG 06695
gene id: 229533:FGSG_06695
uniprot id: I1RRH4
names: Function
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).

229533:FGSG 03443
gene id: 229533:FGSG_03443
uniprot id: I1RI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

229533:FGSG 07322
gene id: 229533:FGSG_07322
uniprot id: I1RT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

229533:FGSG 01028
gene id: 229533:FGSG_01028
uniprot id: I1RBT8
names: Similarity
messages: Belongs to the HscB family.

229533:FGSG 05505
gene id: 229533:FGSG_05505
uniprot id: I1RND2
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

229533:FGSG 02920
gene id: 229533:FGSG_02920
uniprot id: I1RGP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

229533:FGSG 09816
gene id: 229533:FGSG_09816
uniprot id: A0A1I9FPC3
uniprot id: Q4HYZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex.
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
messages: Vesicle
messages: secretory vesicle

229533:FGSG 06285
gene id: 229533:FGSG_06285
uniprot id: I1RQE3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11022
gene id: 229533:FGSG_11022
uniprot id: I1S2M3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 09996
gene id: 229533:FGSG_09996
uniprot id: I1RZY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 08586
gene id: 229533:FGSG_08586
uniprot id: I1RWC2
names: Similarity
messages: Belongs to the OSBP family.

229533:FGSG 02170
gene id: 229533:FGSG_02170
uniprot id: I1RES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Secreted

229533:FGSG 08335
gene id: 229533:FGSG_08335
uniprot id: I1RVQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

229533:FGSG 12069
gene id: 229533:FGSG_12069
uniprot id: I1S5F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 10388
gene id: 229533:FGSG_10388
uniprot id: I1S0Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

229533:FGSG 00840
gene id: 229533:FGSG_00840
uniprot id: V6QVV9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

229533:FGSG 08485
gene id: 229533:FGSG_08485
uniprot id: I1RW32
names: Similarity
messages: Belongs to the epsin family.

229533:FGSG 13223
gene id: 229533:FGSG_13223
uniprot id: I1S8P5
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 08522
gene id: 229533:FGSG_08522
uniprot id: I1RW65
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

229533:FGSG 00373
gene id: 229533:FGSG_00373
uniprot id: I1RA49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

229533:FGSG 06177
gene id: 229533:FGSG_06177
uniprot id: I1RQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 00906
gene id: 229533:FGSG_00906
uniprot id: I1RBI1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

229533:FGSG 03985
gene id: 229533:FGSG_03985
uniprot id: I1RJG5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00197
gene id: 229533:FGSG_00197
uniprot id: I1R9P4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03700
gene id: 229533:FGSG_03700
uniprot id: I1RIQ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 11627
gene id: 229533:FGSG_11627
uniprot id: A0A1I9FJX4
uniprot id: Q4HTT1
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-6; H2AK7ac = acetylated Lys-10.

229533:FGSG 03667
gene id: 229533:FGSG_03667
uniprot id: I1RIM7
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 03014
gene id: 229533:FGSG_03014
uniprot id: I1RGY2
names: Similarity
messages: Belongs to the hexokinase family.

229533:FGSG 02349
gene id: 229533:FGSG_02349
uniprot id: I1RF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

229533:FGSG 09638
gene id: 229533:FGSG_09638
uniprot id: I1RZ20
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

229533:FGSG 11082
gene id: 229533:FGSG_11082
uniprot id: I1S2S9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 06810
gene id: 229533:FGSG_06810
uniprot id: I1RRS3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01710
gene id: 229533:FGSG_01710
uniprot id: A0A1I9EZP1
uniprot id: Q4IM48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: Probable transporter.
messages: Vacuole membrane

229533:FGSG 00558
gene id: 229533:FGSG_00558
uniprot id: I1RAM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

229533:FGSG 05896
gene id: 229533:FGSG_05896
uniprot id: A0A1I9FRJ6
uniprot id: Q4IA62
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
messages: Membrane
messages: Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: Vacuole membrane

229533:FGSG 05439
gene id: 229533:FGSG_05439
uniprot id: I1RN73
names: Similarity
messages: Belongs to the MIF family.

229533:FGSG 09549
gene id: 229533:FGSG_09549
uniprot id: I1RYU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

229533:FGSG 10982
gene id: 229533:FGSG_10982
uniprot id: I1S2I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Membrane
messages: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Vacuole membrane

229533:FGSG 08817
gene id: 229533:FGSG_08817
uniprot id: I1RWY0
names: Subcellular Location Annotation
messages: Cell membrane

229533:FGSG 01852
gene id: 229533:FGSG_01852
uniprot id: I1RDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.
messages: Endosome membrane
messages: Membrane
messages: Vacuole membrane

229533:FGSG 02169
gene id: 229533:FGSG_02169
uniprot id: I1RER9
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 10257
gene id: 229533:FGSG_10257
uniprot id: I1S0M4
names: Similarity
messages: Belongs to the PhyH family.

229533:FGSG 08915
gene id: 229533:FGSG_08915
uniprot id: Q4I1J3
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

229533:FGSG 05295
gene id: 229533:FGSG_05295
uniprot id: I1RMU5
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 01151
gene id: 229533:FGSG_01151
uniprot id: I1RC48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

229533:FGSG 07257
gene id: 229533:FGSG_07257
uniprot id: I1RSX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

229533:FGSG 07854
gene id: 229533:FGSG_07854
uniprot id: I1RUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

229533:FGSG 07529
gene id: 229533:FGSG_07529
uniprot id: I1RTL8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02671
gene id: 229533:FGSG_02671
uniprot id: I1RG22
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05344
gene id: 229533:FGSG_05344
uniprot id: A0A1I9FYE8
uniprot id: Q4IBR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

229533:FGSG 09764
gene id: 229533:FGSG_09764
uniprot id: I1RZD0
names: Function
names: Induction
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.
messages: Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).

229533:FGSG 03330
gene id: 229533:FGSG_03330
uniprot id: I1RHR7
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09395
gene id: 229533:FGSG_09395
uniprot id: I1RYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

229533:FGSG 00177
gene id: 229533:FGSG_00177
uniprot id: V6R0A3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 00820
gene id: 229533:FGSG_00820
uniprot id: I1RBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus

229533:FGSG 07288
gene id: 229533:FGSG_07288
uniprot id: I1RT00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

229533:FGSG 01513
gene id: 229533:FGSG_01513
uniprot id: I1RD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anthrone oxygenase family.
messages: Membrane

229533:FGSG 02773
gene id: 229533:FGSG_02773
uniprot id: I1RGB5
names: Similarity
messages: Belongs to the MIX23 family.

229533:FGSG 09846
gene id: 229533:FGSG_09846
uniprot id: I1RZJ9
names: Similarity
messages: Belongs to the VAC14 family.

229533:FGSG 07267
gene id: 229533:FGSG_07267
uniprot id: I1RSY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 09245
gene id: 229533:FGSG_09245
uniprot id: I1RY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

229533:FGSG 07897
gene id: 229533:FGSG_07897
uniprot id: O74638
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

229533:FGSG 09115
gene id: 229533:FGSG_09115
uniprot id: I1RXP1
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 03732
gene id: 229533:FGSG_03732
uniprot id: I1RIT8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00291
gene id: 229533:FGSG_00291
uniprot id: I1R9X6
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

229533:FGSG 07604
gene id: 229533:FGSG_07604
uniprot id: I1RTT8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04739
gene id: 229533:FGSG_04739
uniprot id: I1RLE3
names: Subcellular Location Annotation
messages: Cell surface

229533:FGSG 07308
gene id: 229533:FGSG_07308
uniprot id: A0A1I9FPU8
uniprot id: Q4I650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Nucleus

229533:FGSG 07042
gene id: 229533:FGSG_07042
uniprot id: I1RSC6
names: Similarity
messages: Belongs to the TMA16 family.

229533:FGSG 07569
gene id: 229533:FGSG_07569
uniprot id: I1RTQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

229533:FGSG 05974
gene id: 229533:FGSG_05974
uniprot id: I1RPK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 05519
gene id: 229533:FGSG_05519
uniprot id: Q4IB89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
messages: telomere

229533:FGSG 08791
gene id: 229533:FGSG_08791
uniprot id: I1RWV5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01008
gene id: 229533:FGSG_01008
uniprot id: I1RBS0
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

229533:FGSG 09025
gene id: 229533:FGSG_09025
uniprot id: I1RXF8
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.

229533:FGSG 05539
gene id: 229533:FGSG_05539
uniprot id: I1RNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 11375
gene id: 229533:FGSG_11375
uniprot id: I1S3J0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10050
gene id: 229533:FGSG_10050
uniprot id: I1S036
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

229533:FGSG 10855
gene id: 229533:FGSG_10855
uniprot id: I1S269
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 01187
gene id: 229533:FGSG_01187
uniprot id: I1RC84
names: Similarity
messages: Belongs to the SF3A2 family.

229533:FGSG 06111
gene id: 229533:FGSG_06111
uniprot id: I1RPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 10063
gene id: 229533:FGSG_10063
uniprot id: I1S047
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 08099
gene id: 229533:FGSG_08099
uniprot id: I1RV37
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04062
gene id: 229533:FGSG_04062
uniprot id: I1RJN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 05843
gene id: 229533:FGSG_05843
uniprot id: I1RP86
names: Function
names: Similarity
messages: Belongs to the GPI family.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.

229533:FGSG 08022
gene id: 229533:FGSG_08022
uniprot id: I1RUW4
names: Similarity
messages: Belongs to the peptidase M28 family.

229533:FGSG 01302
gene id: 229533:FGSG_01302
uniprot id: I1RCI6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00507
gene id: 229533:FGSG_00507
uniprot id: I1RAH7
names: Similarity
messages: Belongs to the COG4 family.

229533:FGSG 13883
gene id: 229533:FGSG_13883
uniprot id: I1SAK2
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

229533:FGSG 06646
gene id: 229533:FGSG_06646
uniprot id: I1RRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

229533:FGSG 09393
gene id: 229533:FGSG_09393
uniprot id: I1RYE6
names: Function
names: Similarity
messages: Belongs to the RTC5 family.
messages: May be involved in a process influencing telomere capping.

229533:FGSG 13098
gene id: 229533:FGSG_13098
uniprot id: I1S8C0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02063
gene id: 229533:FGSG_02063
uniprot id: I1REH4
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 08511
gene id: 229533:FGSG_08511
uniprot id: V6RKR9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 02661
gene id: 229533:FGSG_02661
uniprot id: I1RG12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

229533:FGSG 11525
gene id: 229533:FGSG_11525
uniprot id: I1S3X5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08478
gene id: 229533:FGSG_08478
uniprot id: I1RW25
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

229533:FGSG 01541
gene id: 229533:FGSG_01541
uniprot id: I1RD52
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

229533:FGSG 07296
gene id: 229533:FGSG_07296
uniprot id: A0A1I9FKK2
uniprot id: Q4I662
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

229533:FGSG 06243
gene id: 229533:FGSG_06243
uniprot id: I1RQA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

229533:FGSG 06512
gene id: 229533:FGSG_06512
uniprot id: I1RR09
names: Subunit
messages: Homodimer.

229533:FGSG 00388
gene id: 229533:FGSG_00388
uniprot id: I1RA63
names: Similarity
messages: Belongs to the oligoribonuclease family.

229533:FGSG 04144
gene id: 229533:FGSG_04144
uniprot id: I1RJW1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

229533:FGSG 00645
gene id: 229533:FGSG_00645
uniprot id: I1RAV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

229533:FGSG 06312
gene id: 229533:FGSG_06312
uniprot id: I1RQH0
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

229533:FGSG 05236
gene id: 229533:FGSG_05236
uniprot id: V6R9T8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

229533:FGSG 08281
gene id: 229533:FGSG_08281
uniprot id: I1RVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

229533:FGSG 10800
gene id: 229533:FGSG_10800
uniprot id: I1S219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

229533:FGSG 10078
gene id: 229533:FGSG_10078
uniprot id: I1S062
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

229533:FGSG 02555
gene id: 229533:FGSG_02555
uniprot id: V6R057
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 12182
gene id: 229533:FGSG_12182
uniprot id: I1S5R1
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

229533:FGSG 08179
gene id: 229533:FGSG_08179
uniprot id: I1RVB2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 13906
gene id: 229533:FGSG_13906
uniprot id: I1SAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

229533:FGSG 01370
gene id: 229533:FGSG_01370
uniprot id: I1RCP6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10426
gene id: 229533:FGSG_10426
uniprot id: I1S132
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

229533:FGSG 02659
gene id: 229533:FGSG_02659
uniprot id: I1RG11
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

229533:FGSG 11810
gene id: 229533:FGSG_11810
uniprot id: I1S4P2
names: Similarity
messages: Belongs to the PPP4R2 family.

229533:FGSG 09661
gene id: 229533:FGSG_09661
uniprot id: I1RZ38
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 05038
gene id: 229533:FGSG_05038
uniprot id: A0A1I9FSY6
uniprot id: Q4ICM0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
messages: Self-associates. Interacts with NDL1 and dynein.
messages: cytoskeleton
messages: spindle pole

229533:FGSG 12264
gene id: 229533:FGSG_12264
uniprot id: I1S5Z3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

229533:FGSG 07549
gene id: 229533:FGSG_07549
uniprot id: I1RTN6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

229533:FGSG 03126
gene id: 229533:FGSG_03126
uniprot id: I1RH81
names: Similarity
messages: Belongs to the tpcK family.

229533:FGSG 10025
gene id: 229533:FGSG_10025
uniprot id: V6RRR4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 09728
gene id: 229533:FGSG_09728
uniprot id: I1RZ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

229533:FGSG 08794
gene id: 229533:FGSG_08794
uniprot id: I1RWV8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10619
gene id: 229533:FGSG_10619
uniprot id: I1S1L2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 06659
gene id: 229533:FGSG_06659
uniprot id: I1RRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

229533:FGSG 09735
gene id: 229533:FGSG_09735
uniprot id: V6RQ48
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

229533:FGSG 07781
gene id: 229533:FGSG_07781
uniprot id: I1RU96
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09138
gene id: 229533:FGSG_09138
uniprot id: I1RXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 10194
gene id: 229533:FGSG_10194
uniprot id: I1S0G7
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 03269
gene id: 229533:FGSG_03269
uniprot id: I1RHL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

229533:FGSG 06133
gene id: 229533:FGSG_06133
uniprot id: I1RQ01
names: Similarity
messages: Belongs to the peptidase M18 family.

229533:FGSG 10040
gene id: 229533:FGSG_10040
uniprot id: A0A1I9F419
uniprot id: Q4HYB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: Nucleus

229533:FGSG 04803
gene id: 229533:FGSG_04803
uniprot id: I1RLK0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03075
gene id: 229533:FGSG_03075
uniprot id: I1RH36
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

229533:FGSG 08808
gene id: 229533:FGSG_08808
uniprot id: I1RWX2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08508
gene id: 229533:FGSG_08508
uniprot id: I1RW53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 07080
gene id: 229533:FGSG_07080
uniprot id: I1RSG2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 12728
gene id: 229533:FGSG_12728
uniprot id: I1S7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 02941
gene id: 229533:FGSG_02941
uniprot id: I1RGR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

229533:FGSG 05728
gene id: 229533:FGSG_05728
uniprot id: I1RNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 07387
gene id: 229533:FGSG_07387
uniprot id: V6RGU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 09342
gene id: 229533:FGSG_09342
uniprot id: V6RNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 06370
gene id: 229533:FGSG_06370
uniprot id: I1RQM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

229533:FGSG 11440
gene id: 229533:FGSG_11440
uniprot id: I1S3P9
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 03918
gene id: 229533:FGSG_03918
uniprot id: I1RJA9
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 03725
gene id: 229533:FGSG_03725
uniprot id: I1RIT1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00231
gene id: 229533:FGSG_00231
uniprot id: V6QTX7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 07866
gene id: 229533:FGSG_07866
uniprot id: I1RUH3
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 07488
gene id: 229533:FGSG_07488
uniprot id: I1RTI0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05854
gene id: 229533:FGSG_05854
uniprot id: I1RP97
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

229533:FGSG 06290
gene id: 229533:FGSG_06290
uniprot id: I1RQE8
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

229533:FGSG 03786
gene id: 229533:FGSG_03786
uniprot id: I1RIY9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08451
gene id: 229533:FGSG_08451
uniprot id: I1RVZ9
names: Similarity
messages: Belongs to the FPG family.

229533:FGSG 10221
gene id: 229533:FGSG_10221
uniprot id: I1S0J3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00309
gene id: 229533:FGSG_00309
uniprot id: I1R9Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

229533:FGSG 05250
gene id: 229533:FGSG_05250
uniprot id: I1RMQ5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

229533:FGSG 07452
gene id: 229533:FGSG_07452
uniprot id: I1RTE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: nucleolus

229533:FGSG 06777
gene id: 229533:FGSG_06777
uniprot id: V6RLW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

229533:FGSG 06554
gene id: 229533:FGSG_06554
uniprot id: I1RR45
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

229533:FGSG 02237
gene id: 229533:FGSG_02237
uniprot id: I1REX8
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

229533:FGSG 08964
gene id: 229533:FGSG_08964
uniprot id: V6RNA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
messages: The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

229533:FGSG 07917
gene id: 229533:FGSG_07917
uniprot id: I1RUL8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10805
gene id: 229533:FGSG_10805
uniprot id: I1S224
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 04271
gene id: 229533:FGSG_04271
uniprot id: I1RK77
names: Similarity
messages: Belongs to the OPI10 family.

229533:FGSG 02059
gene id: 229533:FGSG_02059
uniprot id: I1REH0
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.

229533:FGSG 09244
gene id: 229533:FGSG_09244
uniprot id: I1RY15
names: Similarity
messages: Belongs to the SEC3 family.

229533:FGSG 11628
gene id: 229533:FGSG_11628
uniprot id: I1S464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

229533:FGSG 09512
gene id: 229533:FGSG_09512
uniprot id: I1RYQ4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 07474
gene id: 229533:FGSG_07474
uniprot id: I1RTH0
names: Similarity
messages: Belongs to the WAPL family.

229533:FGSG 01813
gene id: 229533:FGSG_01813
uniprot id: I1RDU6
names: Similarity
messages: Belongs to the DapA family.

229533:FGSG 09675
gene id: 229533:FGSG_09675
uniprot id: I1RZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 07399
gene id: 229533:FGSG_07399
uniprot id: I1RT98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

229533:FGSG 00475
gene id: 229533:FGSG_00475
uniprot id: I1RAE8
names: Function
names: Similarity
messages: Belongs to the NARF family.
messages: Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.

229533:FGSG 13450
gene id: 229533:FGSG_13450
uniprot id: I1S9C0
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 08802
gene id: 229533:FGSG_08802
uniprot id: I1RWW6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07032
gene id: 229533:FGSG_07032
uniprot id: I1RSB8
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

229533:FGSG 01621
gene id: 229533:FGSG_01621
uniprot id: I1RDC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 06800
gene id: 229533:FGSG_06800
uniprot id: I1RRR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 02764
gene id: 229533:FGSG_02764
uniprot id: I1RGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

229533:FGSG 10001
gene id: 229533:FGSG_10001
uniprot id: I1RZZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

229533:FGSG 00218
gene id: 229533:FGSG_00218
uniprot id: I1R9R3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

229533:FGSG 10868
gene id: 229533:FGSG_10868
uniprot id: I1S282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

229533:FGSG 05686
gene id: 229533:FGSG_05686
uniprot id: I1RNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

229533:FGSG 06537
gene id: 229533:FGSG_06537
uniprot id: I1RR30
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 04726
gene id: 229533:FGSG_04726
uniprot id: I1RLD2
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 10789
gene id: 229533:FGSG_10789
uniprot id: I1S209
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

229533:FGSG 10319
gene id: 229533:FGSG_10319
uniprot id: V6RSM7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

229533:FGSG 09879
gene id: 229533:FGSG_09879
uniprot id: I1RZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09368
gene id: 229533:FGSG_09368
uniprot id: I1RYC3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01662
gene id: 229533:FGSG_01662
uniprot id: I1RDG6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07993
gene id: 229533:FGSG_07993
uniprot id: I1RUT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 02675
gene id: 229533:FGSG_02675
uniprot id: I1RG26
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11177
gene id: 229533:FGSG_11177
uniprot id: I1S316
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 05140
gene id: 229533:FGSG_05140
uniprot id: I1RMF1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

229533:FGSG 06509
gene id: 229533:FGSG_06509
uniprot id: A0A1I9FKF3
uniprot id: Q4I8E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in transport through the plasma membrane.

229533:FGSG 01465
gene id: 229533:FGSG_01465
uniprot id: V6QWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

229533:FGSG 09961
gene id: 229533:FGSG_09961
uniprot id: I1RZV6
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 03960
gene id: 229533:FGSG_03960
uniprot id: I1RJE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal hydrophobin family.
messages: cell wall

229533:FGSG 03120
gene id: 229533:FGSG_03120
uniprot id: I1RH75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

229533:FGSG 05094
gene id: 229533:FGSG_05094
uniprot id: I1RMA7
names: Similarity
messages: Belongs to the IST1 family.

229533:FGSG 00506
gene id: 229533:FGSG_00506
uniprot id: I1RAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

229533:FGSG 09195
gene id: 229533:FGSG_09195
uniprot id: I1RXW9
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 06007
gene id: 229533:FGSG_06007
uniprot id: I1RPN2
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

229533:FGSG 01031
gene id: 229533:FGSG_01031
uniprot id: I1RBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

229533:FGSG 09494
gene id: 229533:FGSG_09494
uniprot id: V6RPC7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 02794
gene id: 229533:FGSG_02794
uniprot id: I1RGD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

229533:FGSG 08266
gene id: 229533:FGSG_08266
uniprot id: I1RVI8
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

229533:FGSG 02305
gene id: 229533:FGSG_02305
uniprot id: I1RF39
names: Similarity
messages: Belongs to the peptidase M20A family.

229533:FGSG 09014
gene id: 229533:FGSG_09014
uniprot id: I1RXE8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05277
gene id: 229533:FGSG_05277
uniprot id: I1RMT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

229533:FGSG 03733
gene id: 229533:FGSG_03733
uniprot id: I1RIT9
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 09894
gene id: 229533:FGSG_09894
uniprot id: I1RZP4
names: Similarity
messages: Belongs to the yippee family.

229533:FGSG 02598
gene id: 229533:FGSG_02598
uniprot id: I1RFV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

229533:FGSG 04819
gene id: 229533:FGSG_04819
uniprot id: I1RLL4
names: Similarity
messages: Belongs to the Cyclase 1 superfamily.

229533:FGSG 02244
gene id: 229533:FGSG_02244
uniprot id: I1REY5
names: Similarity
messages: Belongs to the peptidase M20A family.

229533:FGSG 10730
gene id: 229533:FGSG_10730
uniprot id: I1S1V7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

229533:FGSG 07396
gene id: 229533:FGSG_07396
uniprot id: I1RT95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

229533:FGSG 01264
gene id: 229533:FGSG_01264
uniprot id: I1RCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

229533:FGSG 04786
gene id: 229533:FGSG_04786
uniprot id: I1RLI4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10186
gene id: 229533:FGSG_10186
uniprot id: I1S0G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

229533:FGSG 03174
gene id: 229533:FGSG_03174
uniprot id: I1RHC8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

229533:FGSG 10020
gene id: 229533:FGSG_10020
uniprot id: I1S009
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.

229533:FGSG 09162
gene id: 229533:FGSG_09162
uniprot id: V6RUT5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

229533:FGSG 04042
gene id: 229533:FGSG_04042
uniprot id: I1RJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

229533:FGSG 09438
gene id: 229533:FGSG_09438
uniprot id: I1RYI5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

229533:FGSG 05778
gene id: 229533:FGSG_05778
uniprot id: I1RP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

229533:FGSG 04901
gene id: 229533:FGSG_04901
uniprot id: I1RLT2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02060
gene id: 229533:FGSG_02060
uniprot id: I1REH1
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

229533:FGSG 01421
gene id: 229533:FGSG_01421
uniprot id: I1RCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 07425
gene id: 229533:FGSG_07425
uniprot id: I1RTC4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10999
gene id: 229533:FGSG_10999
uniprot id: A0A1I9FXT9
uniprot id: I1S2K3
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.
messages: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.
messages: Expression is highly induced by xylan.
messages: Inhibited by the proteinaceous endoxylanase inhibitor I from T.aestivum (TAXI-I).
messages: Secreted

229533:FGSG 01243
gene id: 229533:FGSG_01243
uniprot id: V6QW25
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

229533:FGSG 10192
gene id: 229533:FGSG_10192
uniprot id: I1S0G5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

229533:FGSG 00620
gene id: 229533:FGSG_00620
uniprot id: I1RAT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 04430
gene id: 229533:FGSG_04430
uniprot id: I1RKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 08799
gene id: 229533:FGSG_08799
uniprot id: I1RWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 13983
gene id: 229533:FGSG_13983
uniprot id: I1SAV2
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 06411
gene id: 229533:FGSG_06411
uniprot id: I1RQR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

229533:FGSG 02329
gene id: 229533:FGSG_02329
uniprot id: I1RF63
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).
messages: Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:21296881).
messages: Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).
messages: Part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: Secreted
messages: extracellular space

229533:FGSG 01854
gene id: 229533:FGSG_01854
uniprot id: I1RDY5
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 07411
gene id: 229533:FGSG_07411
uniprot id: I1RTB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 07794
gene id: 229533:FGSG_07794
uniprot id: V6RI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 03851
gene id: 229533:FGSG_03851
uniprot id: I1RJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

229533:FGSG 04313
gene id: 229533:FGSG_04313
uniprot id: I1RKB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

229533:FGSG 10188
gene id: 229533:FGSG_10188
uniprot id: I1S0G2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

229533:FGSG 13014
gene id: 229533:FGSG_13014
uniprot id: I1S838
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

229533:FGSG 09386
gene id: 229533:FGSG_09386
uniprot id: I1RYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

229533:FGSG 00353
gene id: 229533:FGSG_00353
uniprot id: I1RA32
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

229533:FGSG 00609
gene id: 229533:FGSG_00609
uniprot id: I1RAS4
names: Similarity
messages: Belongs to the RutC family.

229533:FGSG 06406
gene id: 229533:FGSG_06406
uniprot id: I1RQQ8
names: Similarity
messages: Belongs to the phosducin family.

229533:FGSG 08587
gene id: 229533:FGSG_08587
uniprot id: I1RWC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.

229533:FGSG 05471
gene id: 229533:FGSG_05471
uniprot id: V6RAZ6
names: Similarity
messages: Belongs to the peptidase A1 family.

229533:FGSG 00794
gene id: 229533:FGSG_00794
uniprot id: I1RB86
names: Similarity
messages: Belongs to the CACTIN family.

229533:FGSG 00819
gene id: 229533:FGSG_00819
uniprot id: A0A1I9EWN3
uniprot id: Q4IPN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

229533:FGSG 01349
gene id: 229533:FGSG_01349
uniprot id: I1RCM8
names: Similarity
messages: Belongs to the diacylglycerol acyltransferase family.

229533:FGSG 04776
gene id: 229533:FGSG_04776
uniprot id: I1RLH6
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 10368
gene id: 229533:FGSG_10368
uniprot id: I1S0X6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.

229533:FGSG 06731
gene id: 229533:FGSG_06731
uniprot id: I1RRK4
names: Similarity
messages: Belongs to the UPF0045 family.

229533:FGSG 02142
gene id: 229533:FGSG_02142
uniprot id: I1REP8
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 06035
gene id: 229533:FGSG_06035
uniprot id: I1RPQ7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 13660
gene id: 229533:FGSG_13660
uniprot id: I1S9X9
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
messages: Golgi apparatus membrane
messages: Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.
messages: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236, PubMed:30044782). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236). Required for aerial hyphae development and lipid droplet degradation in response to starvation (PubMed:30044782).
messages: Phosphorylated by ATG1 (By similarity). ATG1 phosphorylation is required for ATG18 interaction and preautophagosome elongation (By similarity).
messages: Preautophagosomal structure membrane
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Blocks autophagy (PubMed:30044782).

229533:FGSG 02658
gene id: 229533:FGSG_02658
uniprot id: I1RG10
names: Similarity
messages: Belongs to the glycosyl hydrolase 45 (cellulase K) family.

229533:FGSG 09724
gene id: 229533:FGSG_09724
uniprot id: I1RZ94
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

229533:FGSG 01737
gene id: 229533:FGSG_01737
uniprot id: I1RDM7
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 09761
gene id: 229533:FGSG_09761
uniprot id: A0A1I9FQ50
uniprot id: Q4HZ47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.
messages: nucleolus

229533:FGSG 05321
gene id: 229533:FGSG_05321
uniprot id: I1RMW8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

229533:FGSG 02079
gene id: 229533:FGSG_02079
uniprot id: I1REJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 00895
gene id: 229533:FGSG_00895
uniprot id: I1RBH2
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

229533:FGSG 12275
gene id: 229533:FGSG_12275
uniprot id: I1S604
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01463
gene id: 229533:FGSG_01463
uniprot id: I1RCX9
names: Similarity
messages: Belongs to the RENT3 family.

229533:FGSG 01220
gene id: 229533:FGSG_01220
uniprot id: I1RCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

229533:FGSG 10158
gene id: 229533:FGSG_10158
uniprot id: I1S0D5
names: Similarity
messages: Belongs to the RAD52 family.

229533:FGSG 05766
gene id: 229533:FGSG_05766
uniprot id: I1RP18
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

229533:FGSG 03533
gene id: 229533:FGSG_03533
uniprot id: I1RIA3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08378
gene id: 229533:FGSG_08378
uniprot id: I1RVT5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

229533:FGSG 12703
gene id: 229533:FGSG_12703
uniprot id: I1S780
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03467
gene id: 229533:FGSG_03467
uniprot id: I1RI44
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M36 family.
messages: Binds 1 zinc ion per subunit.
messages: Secreted

229533:FGSG 06751
gene id: 229533:FGSG_06751
uniprot id: I1RRM1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 04304
gene id: 229533:FGSG_04304
uniprot id: I1RKA7
names: Function
names: Similarity
messages: Belongs to the WD repeat CIA1 family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

229533:FGSG 00194
gene id: 229533:FGSG_00194
uniprot id: I1R9P1
names: Similarity
messages: Belongs to the serine esterase family.

229533:FGSG 13084
gene id: 229533:FGSG_13084
uniprot id: I1S8A6
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06612
gene id: 229533:FGSG_06612
uniprot id: I1RR96
names: Cofactor
messages: Binds 2 manganese ions per subunit.

229533:FGSG 02922
gene id: 229533:FGSG_02922
uniprot id: I1RGP9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 02398
gene id: 229533:FGSG_02398
uniprot id: I1RFC6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).
messages: Impairs the expression of the zearalenone biosynthesis cluster genes and results in the loss of beta-zearalenonol and zearalenone production (PubMed:16262793).
messages: Nucleus
messages: Transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes (PubMed:16262793).

229533:FGSG 01411
gene id: 229533:FGSG_01411
uniprot id: A0A1I9EYP3
uniprot id: Q4IMZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

229533:FGSG 08595
gene id: 229533:FGSG_08595
uniprot id: I1RWD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

229533:FGSG 09904
gene id: 229533:FGSG_09904
uniprot id: A0A1I9F3T8
uniprot id: Q4HYQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.

229533:FGSG 00188
gene id: 229533:FGSG_00188
uniprot id: I1R9N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

229533:FGSG 05619
gene id: 229533:FGSG_05619
uniprot id: I1RNN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

229533:FGSG 04709
gene id: 229533:FGSG_04709
uniprot id: I1RLC2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00718
gene id: 229533:FGSG_00718
uniprot id: V6QVH2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 05509
gene id: 229533:FGSG_05509
uniprot id: I1RND6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

229533:FGSG 08627
gene id: 229533:FGSG_08627
uniprot id: I1RWF9
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

229533:FGSG 13008
gene id: 229533:FGSG_13008
uniprot id: I1S832
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07122
gene id: 229533:FGSG_07122
uniprot id: I1RSK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 04398
gene id: 229533:FGSG_04398
uniprot id: I1RKJ2
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 12302
gene id: 229533:FGSG_12302
uniprot id: Q4IF76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
messages: Associates with polysomes.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 01123
gene id: 229533:FGSG_01123
uniprot id: I1RC22
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

229533:FGSG 00226
gene id: 229533:FGSG_00226
uniprot id: I1R9S0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05733
gene id: 229533:FGSG_05733
uniprot id: I1RNY6
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

229533:FGSG 10828
gene id: 229533:FGSG_10828
uniprot id: I1S244
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 09607
gene id: 229533:FGSG_09607
uniprot id: I1RYZ1
names: Subunit
messages: Consists of at least two heavy chains and a number of intermediate and light chains.

229533:FGSG 01464
gene id: 229533:FGSG_01464
uniprot id: I1RCY0
names: Similarity
messages: Belongs to the PPP phosphatase family.

229533:FGSG 04240
gene id: 229533:FGSG_04240
uniprot id: I1RK52
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08621
gene id: 229533:FGSG_08621
uniprot id: Q4I2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

229533:FGSG 08417
gene id: 229533:FGSG_08417
uniprot id: I1RVX0
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

229533:FGSG 00286
gene id: 229533:FGSG_00286
uniprot id: I1R9X2
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

229533:FGSG 06126
gene id: 229533:FGSG_06126
uniprot id: I1RPZ4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10373
gene id: 229533:FGSG_10373
uniprot id: I1S0Y1
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

229533:FGSG 06002
gene id: 229533:FGSG_06002
uniprot id: I1RPM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

229533:FGSG 12846
gene id: 229533:FGSG_12846
uniprot id: I1S7M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

229533:FGSG 08615
gene id: 229533:FGSG_08615
uniprot id: I1RWE9
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

229533:FGSG 01910
gene id: 229533:FGSG_01910
uniprot id: I1RE37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

229533:FGSG 00013
gene id: 229533:FGSG_00013
uniprot id: I1R985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01017
gene id: 229533:FGSG_01017
uniprot id: I1RBS7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

229533:FGSG 00893
gene id: 229533:FGSG_00893
uniprot id: I1RBH0
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 02668
gene id: 229533:FGSG_02668
uniprot id: I1RG19
names: Subunit
messages: Homotetramer.

229533:FGSG 01189
gene id: 229533:FGSG_01189
uniprot id: I1RC86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM54 family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 08669
gene id: 229533:FGSG_08669
uniprot id: I1RWJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 01912
gene id: 229533:FGSG_01912
uniprot id: I1RE39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 03693
gene id: 229533:FGSG_03693
uniprot id: I1RIQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

229533:FGSG 12984
gene id: 229533:FGSG_12984
uniprot id: I1S809
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07939
gene id: 229533:FGSG_07939
uniprot id: I1RUN9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

229533:FGSG 10733
gene id: 229533:FGSG_10733
uniprot id: I1S1V9
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

229533:FGSG 07213
gene id: 229533:FGSG_07213
uniprot id: I1RST0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

229533:FGSG 07875
gene id: 229533:FGSG_07875
uniprot id: I1RUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 03713
gene id: 229533:FGSG_03713
uniprot id: I1RIR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

229533:FGSG 09421
gene id: 229533:FGSG_09421
uniprot id: I1RYH0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

229533:FGSG 09530
gene id: 229533:FGSG_09530
uniprot id: A0A1I9FP50
uniprot id: Q4HZS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

229533:FGSG 03666
gene id: 229533:FGSG_03666
uniprot id: I1RIM6
names: Similarity
messages: Belongs to the CoA-transferase III family.

229533:FGSG 08431
gene id: 229533:FGSG_08431
uniprot id: I1RVY4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06356
gene id: 229533:FGSG_06356
uniprot id: I1RQL1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00047
gene id: 229533:FGSG_00047
uniprot id: I1R9B4
names: Function
names: Similarity
messages: Belongs to the AMT4 thioesterase family.
messages: Probable thioesterase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

229533:FGSG 01398
gene id: 229533:FGSG_01398
uniprot id: V6QXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

229533:FGSG 10939
gene id: 229533:FGSG_10939
uniprot id: I1S2E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

229533:FGSG 01403
gene id: 229533:FGSG_01403
uniprot id: I1RCS6
names: Similarity
messages: Belongs to the WrbA family.

229533:FGSG 01312
gene id: 229533:FGSG_01312
uniprot id: I1RCJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 03664
gene id: 229533:FGSG_03664
uniprot id: I1RIM5
names: Similarity
messages: Belongs to the peptidase S66 family.

229533:FGSG 01418
gene id: 229533:FGSG_01418
uniprot id: I1RCT8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11891
gene id: 229533:FGSG_11891
uniprot id: I1S4X3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04125
gene id: 229533:FGSG_04125
uniprot id: I1RJU3
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

229533:FGSG 08800
gene id: 229533:FGSG_08800
uniprot id: I1RWW4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

229533:FGSG 13551
gene id: 229533:FGSG_13551
uniprot id: I1S9M0
names: Similarity
messages: Belongs to the CWC16 family.

229533:FGSG 09148
gene id: 229533:FGSG_09148
uniprot id: I1RXS3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

229533:FGSG 01439
gene id: 229533:FGSG_01439
uniprot id: I1RCV7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00067
gene id: 229533:FGSG_00067
uniprot id: I1R9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 03209
gene id: 229533:FGSG_03209
uniprot id: I1RHF8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 05429
gene id: 229533:FGSG_05429
uniprot id: I1RN64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

229533:FGSG 06615
gene id: 229533:FGSG_06615
uniprot id: I1RR99
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

229533:FGSG 01782
gene id: 229533:FGSG_01782
uniprot id: I1RDR7
names: Similarity
messages: Belongs to the OsmC/Ohr family.

229533:FGSG 09653
gene id: 229533:FGSG_09653
uniprot id: I1RZ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 08106
gene id: 229533:FGSG_08106
uniprot id: I1RV44
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05300
gene id: 229533:FGSG_05300
uniprot id: I1RMV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

229533:FGSG 05305
gene id: 229533:FGSG_05305
uniprot id: I1RMV5
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

229533:FGSG 09239
gene id: 229533:FGSG_09239
uniprot id: I1RY11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

229533:FGSG 07107
gene id: 229533:FGSG_07107
uniprot id: I1RSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

229533:FGSG 03111
gene id: 229533:FGSG_03111
uniprot id: I1RH67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

229533:FGSG 00744
gene id: 229533:FGSG_00744
uniprot id: I1RB39
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 05063
gene id: 229533:FGSG_05063
uniprot id: I1RM80
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 11062
gene id: 229533:FGSG_11062
uniprot id: I1S2R2
names: Similarity
messages: Belongs to the GST superfamily.

229533:FGSG 07765
gene id: 229533:FGSG_07765
uniprot id: I1RU81
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 10066
gene id: 229533:FGSG_10066
uniprot id: I1S050
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 11623
gene id: 229533:FGSG_11623
uniprot id: I1S462
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

229533:FGSG 09519
gene id: 229533:FGSG_09519
uniprot id: I1RYR1
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

229533:FGSG 10944
gene id: 229533:FGSG_10944
uniprot id: I1S2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

229533:FGSG 00778
gene id: 229533:FGSG_00778
uniprot id: I1RB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

229533:FGSG 05147
gene id: 229533:FGSG_05147
uniprot id: I1RMF8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01430
gene id: 229533:FGSG_01430
uniprot id: I1RCU8
names: Similarity
messages: Belongs to the FGGY kinase family.

229533:FGSG 06593
gene id: 229533:FGSG_06593
uniprot id: I1RR79
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09577
gene id: 229533:FGSG_09577
uniprot id: I1RYW6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

229533:FGSG 07942
gene id: 229533:FGSG_07942
uniprot id: I1RUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.

229533:FGSG 14036
gene id: 229533:FGSG_14036
uniprot id: I1SB04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRG family.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

229533:FGSG 00280
gene id: 229533:FGSG_00280
uniprot id: I1R9W6
names: Similarity
messages: Belongs to the acetyltransferase family. GCN5 subfamily.

229533:FGSG 08696
gene id: 229533:FGSG_08696
uniprot id: I1RWM0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 12671
gene id: 229533:FGSG_12671
uniprot id: I1S748
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

229533:FGSG 02540
gene id: 229533:FGSG_02540
uniprot id: I1RFQ5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01155
gene id: 229533:FGSG_01155
uniprot id: I1RC52
names: Similarity
messages: Belongs to the VPS26 family.

229533:FGSG 00166
gene id: 229533:FGSG_00166
uniprot id: I1R9L9
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

229533:FGSG 11387
gene id: 229533:FGSG_11387
uniprot id: I1S3K0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 09289
gene id: 229533:FGSG_09289
uniprot id: I1RY54
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

229533:FGSG 05806
gene id: 229533:FGSG_05806
uniprot id: I1RP54
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 02491
gene id: 229533:FGSG_02491
uniprot id: I1RFL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

229533:FGSG 03583
gene id: 229533:FGSG_03583
uniprot id: I1RIF1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

229533:FGSG 05156
gene id: 229533:FGSG_05156
uniprot id: I1RMG6
names: Similarity
messages: Belongs to the OMP decarboxylase family.

229533:FGSG 07954
gene id: 229533:FGSG_07954
uniprot id: A0A1I9FLU5
uniprot id: Q4I4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
messages: cis-Golgi network membrane

229533:FGSG 09666
gene id: 229533:FGSG_09666
uniprot id: I1RZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 08985
gene id: 229533:FGSG_08985
uniprot id: I1RXC1
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

229533:FGSG 00833
gene id: 229533:FGSG_00833
uniprot id: I1RBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Endoplasmic reticulum membrane

229533:FGSG 06670
gene id: 229533:FGSG_06670
uniprot id: I1RRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

229533:FGSG 08277
gene id: 229533:FGSG_08277
uniprot id: I1RVJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

229533:FGSG 02327
gene id: 229533:FGSG_02327
uniprot id: I1RF61
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FMO family.
messages: Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).
messages: Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:16879655).
messages: Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).
messages: Monooxygenase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
messages: Secreted
messages: extracellular space

229533:FGSG 00818
gene id: 229533:FGSG_00818
uniprot id: I1RBA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

229533:FGSG 08576
gene id: 229533:FGSG_08576
uniprot id: I1RWB3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06260
gene id: 229533:FGSG_06260
uniprot id: Q4I948
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

229533:FGSG 05561
gene id: 229533:FGSG_05561
uniprot id: I1RNI0
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

229533:FGSG 10716
gene id: 229533:FGSG_10716
uniprot id: A0A1I9FUR3
uniprot id: Q4HWE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II.

229533:FGSG 03379
gene id: 229533:FGSG_03379
uniprot id: I1RHW3
names: Similarity
messages: Belongs to the RNase T2 family.

229533:FGSG 00949
gene id: 229533:FGSG_00949
uniprot id: I1RBM1
names: Similarity
messages: Belongs to the MEMO1 family.

229533:FGSG 01839
gene id: 229533:FGSG_01839
uniprot id: I1RDX0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

229533:FGSG 06761
gene id: 229533:FGSG_06761
uniprot id: I1RRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

229533:FGSG 05062
gene id: 229533:FGSG_05062
uniprot id: I1RM79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 05508
gene id: 229533:FGSG_05508
uniprot id: I1RND5
names: Function
names: Similarity
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.

229533:FGSG 03889
gene id: 229533:FGSG_03889
uniprot id: I1RJ81
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 03284
gene id: 229533:FGSG_03284
uniprot id: I1RHM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

229533:FGSG 05455
gene id: 229533:FGSG_05455
uniprot id: I1RN89
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

229533:FGSG 06390
gene id: 229533:FGSG_06390
uniprot id: I1RQP3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02341
gene id: 229533:FGSG_02341
uniprot id: I1RF75
names: Similarity
messages: Belongs to the chloroperoxidase family.

229533:FGSG 09770
gene id: 229533:FGSG_09770
uniprot id: I1RZD4
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06516
gene id: 229533:FGSG_06516
uniprot id: I1RR13
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07016
gene id: 229533:FGSG_07016
uniprot id: I1RSA2
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

229533:FGSG 03692
gene id: 229533:FGSG_03692
uniprot id: I1RIQ0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08933
gene id: 229533:FGSG_08933
uniprot id: I1RX81
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06963
gene id: 229533:FGSG_06963
uniprot id: I1RS52
names: Similarity
messages: Belongs to the TIP41 family.

229533:FGSG 06655
gene id: 229533:FGSG_06655
uniprot id: I1RRD6
names: Similarity
messages: Belongs to the peptidase M18 family.

229533:FGSG 03033
gene id: 229533:FGSG_03033
uniprot id: I1RGZ9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 09123
gene id: 229533:FGSG_09123
uniprot id: I1RXP9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08567
gene id: 229533:FGSG_08567
uniprot id: I1RWA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 09828
gene id: 229533:FGSG_09828
uniprot id: I1RZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

229533:FGSG 01729
gene id: 229533:FGSG_01729
uniprot id: I1RDM0
names: Similarity
messages: Belongs to the proline racemase family.

229533:FGSG 12955
gene id: 229533:FGSG_12955
uniprot id: I1S7Y0
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

229533:FGSG 06606
gene id: 229533:FGSG_06606
uniprot id: I1RR90
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:21436218). Catalyzes the reduction of the C14=C15 double bond within 4,4,24-trimethyl ergosta-8,14,24(28)-trienolto produce 4,4-dimethylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a sc…
messages: Endoplasmic reticulum membrane
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4.
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: In contrast to the disruption of ERG24B, does not affect sensitivity to amine fungicides.

229533:FGSG 01569
gene id: 229533:FGSG_01569
uniprot id: I1RD77
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 01765
gene id: 229533:FGSG_01765
uniprot id: I1RDQ1
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 10007
gene id: 229533:FGSG_10007
uniprot id: I1RZZ6
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.

229533:FGSG 05207
gene id: 229533:FGSG_05207
uniprot id: I1RML5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05865
gene id: 229533:FGSG_05865
uniprot id: I1RPA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

229533:FGSG 06811
gene id: 229533:FGSG_06811
uniprot id: I1RRS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

229533:FGSG 09520
gene id: 229533:FGSG_09520
uniprot id: I1RYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

229533:FGSG 03971
gene id: 229533:FGSG_03971
uniprot id: I1RJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-platanin family.
messages: Secreted

229533:FGSG 06551
gene id: 229533:FGSG_06551
uniprot id: I1RR42
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10527
gene id: 229533:FGSG_10527
uniprot id: I1S1C7
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

229533:FGSG 02051
gene id: 229533:FGSG_02051
uniprot id: I1REG3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

229533:FGSG 05272
gene id: 229533:FGSG_05272
uniprot id: I1RMS5
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

229533:FGSG 01997
gene id: 229533:FGSG_01997
uniprot id: I1REB3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01186
gene id: 229533:FGSG_01186
uniprot id: I1RC83
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 11395
gene id: 229533:FGSG_11395
uniprot id: I1S3K7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Expression is induced during the infection of wheat and barley.
messages: Impairs the production of chrysogine.
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. VerP has the following architecture: A-T-C-A-T-C.
messages: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).

229533:FGSG 06074
gene id: 229533:FGSG_06074
uniprot id: I1RPU4
names: Similarity
messages: Belongs to the APC1 family.

229533:FGSG 00911
gene id: 229533:FGSG_00911
uniprot id: I1RBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

229533:FGSG 06936
gene id: 229533:FGSG_06936
uniprot id: I1RS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

229533:FGSG 02639
gene id: 229533:FGSG_02639
uniprot id: I1RFZ2
names: Similarity
messages: Belongs to the MAD2 family.

229533:FGSG 09681
gene id: 229533:FGSG_09681
uniprot id: I1RZ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

229533:FGSG 06733
gene id: 229533:FGSG_06733
uniprot id: I1RRK5
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

229533:FGSG 01519
gene id: 229533:FGSG_01519
uniprot id: Q4IMN9
names: Similarity
messages: Belongs to the CSN12 family.

229533:FGSG 12851
gene id: 229533:FGSG_12851
uniprot id: I1S7M8
names: Similarity
messages: Belongs to the allantoicase family.

229533:FGSG 07180
gene id: 229533:FGSG_07180
uniprot id: I1RSQ2
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

229533:FGSG 04485
gene id: 229533:FGSG_04485
uniprot id: I1RKR9
names: Similarity
messages: Belongs to the actin family.

229533:FGSG 08209
gene id: 229533:FGSG_08209
uniprot id: I1RVD9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase (By similarity). NRPS7 has the following architecture: C-A-T-C-A-T-C-A-T-Cy. The last condensation domain (Cy) could be responsible for cyclization of the final product (Probable).
messages: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).
messages: impairs the production of fusaristatin A.

229533:FGSG 04290
gene id: 229533:FGSG_04290
uniprot id: A0A1I9FG17
uniprot id: Q4IER8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

229533:FGSG 02347
gene id: 229533:FGSG_02347
uniprot id: I1RF80
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

229533:FGSG 05809
gene id: 229533:FGSG_05809
uniprot id: I1RP57
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

229533:FGSG 02811
gene id: 229533:FGSG_02811
uniprot id: I1RGF1
names: Subcellular Location Annotation
messages: Cytoplasm

229533:FGSG 03737
gene id: 229533:FGSG_03737
uniprot id: I1RIU3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11088
gene id: 229533:FGSG_11088
uniprot id: I1S2T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

229533:FGSG 00387
gene id: 229533:FGSG_00387
uniprot id: I1RA62
names: Similarity
messages: Belongs to the phosphohexose mutase family.

229533:FGSG 01740
gene id: 229533:FGSG_01740
uniprot id: I1RDN0
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 01353
gene id: 229533:FGSG_01353
uniprot id: I1RCN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

229533:FGSG 06382
gene id: 229533:FGSG_06382
uniprot id: I1RQN6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03438
gene id: 229533:FGSG_03438
uniprot id: I1RI18
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 09689
gene id: 229533:FGSG_09689
uniprot id: I1RZ63
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

229533:FGSG 00561
gene id: 229533:FGSG_00561
uniprot id: I1RAM9
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 06089
gene id: 229533:FGSG_06089
uniprot id: I1RPV7
names: Function
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

229533:FGSG 06900
gene id: 229533:FGSG_06900
uniprot id: I1RRZ6
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

229533:FGSG 09908
gene id: 229533:FGSG_09908
uniprot id: I1RZQ6
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.

229533:FGSG 02264
gene id: 229533:FGSG_02264
uniprot id: I1RF03
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11355
gene id: 229533:FGSG_11355
uniprot id: I1S3H3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06227
gene id: 229533:FGSG_06227
uniprot id: I1RQ88
names: Similarity
messages: Belongs to the CDC73 family.

229533:FGSG 05093
gene id: 229533:FGSG_05093
uniprot id: A0A1I9FSK4
uniprot id: Q4ICG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: coated pit

229533:FGSG 04782
gene id: 229533:FGSG_04782
uniprot id: I1RLI0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 03729
gene id: 229533:FGSG_03729
uniprot id: I1RIT5
names: Similarity
messages: Belongs to the paxM FAD-dependent monooxygenase family.

229533:FGSG 02790
gene id: 229533:FGSG_02790
uniprot id: I1RGD1
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

229533:FGSG 06294
gene id: 229533:FGSG_06294
uniprot id: I1RQF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

229533:FGSG 00629
gene id: 229533:FGSG_00629
uniprot id: I1RAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

229533:FGSG 05689
gene id: 229533:FGSG_05689
uniprot id: I1RNU7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

229533:FGSG 00969
gene id: 229533:FGSG_00969
uniprot id: I1RBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

229533:FGSG 06319
gene id: 229533:FGSG_06319
uniprot id: I1RQH6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

229533:FGSG 03626
gene id: 229533:FGSG_03626
uniprot id: I1RII9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 04981
gene id: 229533:FGSG_04981
uniprot id: I1RM08
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

229533:FGSG 08900
gene id: 229533:FGSG_08900
uniprot id: I1RX50
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8 (By similarity). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE) (By similarity). This step is required for the membrane association of ATG8 (By similarity). The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Monomer (By similarity). Interacts with ATG8 through an intermediate thioester bond between Cys-244 and the C-terminal Gly of ATG8 (By similarity). Interacts with the C-terminal region of the E1-like ATG7 enzyme (By similarity). Interacts also with the ATG12-ATG5 conjugate (By similarity).
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Strongly reduces the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation (By similarity).
messages: The flexible region (FR) is required for ATG7-binding (By similarity).
messages: The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8 (By similarity). It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).

229533:FGSG 05374
gene id: 229533:FGSG_05374
uniprot id: I1RN16
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 04869
gene id: 229533:FGSG_04869
uniprot id: I1RLQ5
names: Similarity
messages: Belongs to the tyrosinase family.

229533:FGSG 13380
gene id: 229533:FGSG_13380
uniprot id: I1S950
names: Subcellular Location Annotation
messages: Peroxisome membrane

229533:FGSG 04213
gene id: 229533:FGSG_04213
uniprot id: I1RK25
names: Subcellular Location Annotation
messages: Secreted

229533:FGSG 06792
gene id: 229533:FGSG_06792
uniprot id: I1RRQ7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

229533:FGSG 13617
gene id: 229533:FGSG_13617
uniprot id: I1S9T6
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

229533:FGSG 13386
gene id: 229533:FGSG_13386
uniprot id: I1S956
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05709
gene id: 229533:FGSG_05709
uniprot id: I1RNW6
names: Similarity
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.

229533:FGSG 00271
gene id: 229533:FGSG_00271
uniprot id: A0A1I9EUS9
uniprot id: Q4IR87
names: Caution
names: Similarity
messages: Although strongly related to the peptide:N-glycanase enzyme, it lacks the conserved active site Cys in position 243, which is replaced by a Val residue suggesting that it has no activity.
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

229533:FGSG 08834
gene id: 229533:FGSG_08834
uniprot id: I1RWZ4
names: Subunit
messages: Homodimer.

229533:FGSG 00466
gene id: 229533:FGSG_00466
uniprot id: I1RAD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

229533:FGSG 10530
gene id: 229533:FGSG_10530
uniprot id: I1S1D0
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

229533:FGSG 10404
gene id: 229533:FGSG_10404
uniprot id: I1S111
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

229533:FGSG 04146
gene id: 229533:FGSG_04146
uniprot id: I1RJW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 11169
gene id: 229533:FGSG_11169
uniprot id: I1S308
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

229533:FGSG 10947
gene id: 229533:FGSG_10947
uniprot id: I1S2F5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

229533:FGSG 01336
gene id: 229533:FGSG_01336
uniprot id: I1RCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

229533:FGSG 08443
gene id: 229533:FGSG_08443
uniprot id: I1RVZ3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

229533:FGSG 06315
gene id: 229533:FGSG_06315
uniprot id: I1RQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

229533:FGSG 06827
gene id: 229533:FGSG_06827
uniprot id: I1RRT8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.

229533:FGSG 08738
gene id: 229533:FGSG_08738
uniprot id: I1RWQ8
names: Similarity
messages: Belongs to the NEMF family.

229533:FGSG 09020
gene id: 229533:FGSG_09020
uniprot id: I1RXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

229533:FGSG 05447
gene id: 229533:FGSG_05447
uniprot id: I1RN81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

229533:FGSG 07104
gene id: 229533:FGSG_07104
uniprot id: I1RSI3
names: Subcellular Location Annotation
messages: cytosol

229533:FGSG 11597
gene id: 229533:FGSG_11597
uniprot id: I1S439
names: Similarity
messages: Belongs to the AAA ATPase family.

229533:FGSG 10265
gene id: 229533:FGSG_10265
uniprot id: I1S0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

229533:FGSG 03194
gene id: 229533:FGSG_03194
uniprot id: I1RHE5
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

229533:FGSG 04037
gene id: 229533:FGSG_04037
uniprot id: I1RJL2
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

229533:FGSG 02783
gene id: 229533:FGSG_02783
uniprot id: I1RGC4
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).
messages: In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.
messages: Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG6A and ERG6B methylate lanosterol at C-24 to produce eburicol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticu…

229533:FGSG 10288
gene id: 229533:FGSG_10288
uniprot id: I1S0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

229533:FGSG 08458
gene id: 229533:FGSG_08458
uniprot id: I1RW06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

229533:FGSG 09011
gene id: 229533:FGSG_09011
uniprot id: I1RXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

229533:FGSG 05372
gene id: 229533:FGSG_05372
uniprot id: I1RN14
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the NRP synthetase family.
messages: Leads to defective intracellular siderophore (ferricrocin) biosynthesis and sexual development (PubMed:17601875).
messages: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). NPS2 has the following architecture: A-T-C-A-T-C-A-T-C-A-T-C-T-C-T-C (PubMed:17043871).
messages: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875).

229533:FGSG 10306
gene id: 229533:FGSG_10306
uniprot id: I1S0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

229533:FGSG 06445
gene id: 229533:FGSG_06445
uniprot id: A0A1I9FKF2
uniprot id: I1RQU5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.
messages: Expression is under the control of transcription factor XYR1 and highly induced by xylan.
messages: Secreted

229533:FGSG 00690
gene id: 229533:FGSG_00690
uniprot id: I1RAZ3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

229533:FGSG 07302
gene id: 229533:FGSG_07302
uniprot id: I1RT12
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

229533:FGSG 08375
gene id: 229533:FGSG_08375
uniprot id: I1RVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 04902
gene id: 229533:FGSG_04902
uniprot id: I1RLT3
names: Similarity
messages: Belongs to the oxoprolinase family.

229533:FGSG 06389
gene id: 229533:FGSG_06389
uniprot id: I1RQP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD4 family.
messages: Nucleus
messages: kinetochore
messages: spindle

229533:FGSG 06510
gene id: 229533:FGSG_06510
uniprot id: I1RR07
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophagy-specific protein that functions with ATG13, ATG29, and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation (By similarity). Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles, through interacting with and regulating ATG1 kinase activity (By similarity). Plays particularly a role in pexophagy and nucleophagy (By similarity). With ATG13, is required for ATG1 activation by autophosphorylation (By similarity). Recruits ATG9 to the pre-autophagosomal structure (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).
messages: Forms a complex with ATG13, ATG29 and CIS1/ATG31 (By similarity). The ATG17-ATG29-ATG31 complex interacts with the ATG1-ATG13 complex (By similarity). Forms a complex with SNX4 and ATG20 (By similarity). Interacts with ATG11 (By similarity).
messages: Preautophagosomal structure membrane

229533:FGSG 00288
gene id: 229533:FGSG_00288
uniprot id: I1R9X4
names: Similarity
messages: Belongs to the BolA/IbaG family.

229533:FGSG 04297
gene id: 229533:FGSG_04297
uniprot id: I1RKA1
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the PI(3,5)P2 regulatory complex (By similarity). Interacts with ATG2 and ATG9 (By similarity). The ATG2-ATG18 complex is essential for autophagosome formation (By similarity).
messages: Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Plays an important role in osmotically-induced vacuole fragmentation (By similarity). Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy (By similarity). Involved in correct ATG9 trafficking to the pre-autophagosomal structure (By similarity). With ATG2, protects ATG8 from ATG4-mediated cleavage (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: The 377 first amino acids might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane (By similarity). Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P) (By similarity).
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions (By similarity).
messages: Vacuole membrane

229533:FGSG 09783
gene id: 229533:FGSG_09783
uniprot id: I1RZE4
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

229533:FGSG 05271
gene id: 229533:FGSG_05271
uniprot id: I1RMS4
names: Similarity
messages: Belongs to the DCC1 family.

229533:FGSG 00124
gene id: 229533:FGSG_00124
uniprot id: I1R9I3
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

229533:FGSG 13131
gene id: 229533:FGSG_13131
uniprot id: Q4I613
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity).
messages: Divalent metal cation.
messages: Nucleus

229533:FGSG 00657
gene id: 229533:FGSG_00657
uniprot id: I1RAW4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
messages: Component of the heterotrimeric velvet complex composed of laeA, ve1 and velB; Ve1 acting as a bridging protein between laeA and velB (By similarity). Interacts directly with veA (PubMed:23874628).
messages: Constitutively expressed under both trichothecenes mycotoxin production and sexual development conditions (PubMed:23874628).
messages: Cytoplasm
messages: Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23874628). Controls the expression of the mycotoxins trichothecenes and zearalenon gene clusters (PubMed:23874628). Negatively controls perithecial induction, but positively controls virulence toward the host plant (PubMed:23874628).
messages: Nucleus
messages: Strongly reduces expression of the transcription factors TRI6 and ZEB2 that control the biosynthesis of the mycotoxins trichothecenes and zearalenon, respectively (PubMed:23874628). Exhibits an earlier induction of sexual fruiting body (perithecia) formation and drastically reduces disease symptoms in wheat (PubMed:23874628).

229533:FGSG 01607
gene id: 229533:FGSG_01607
uniprot id: I1RDB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

229533:FGSG 00169
gene id: 229533:FGSG_00169
uniprot id: A0A1I9EUF3
uniprot id: Q4IRI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

229533:FGSG 01248
gene id: 229533:FGSG_01248
uniprot id: I1RCD8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

229533:FGSG 08529
gene id: 229533:FGSG_08529
uniprot id: I1RW69
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

229533:FGSG 04361
gene id: 229533:FGSG_04361
uniprot id: I1RKF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

229533:FGSG 00713
gene id: 229533:FGSG_00713
uniprot id: I1RB12
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06959
gene id: 229533:FGSG_06959
uniprot id: V6RFV4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

229533:FGSG 00564
gene id: 229533:FGSG_00564
uniprot id: I1RAN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

229533:FGSG 05281
gene id: 229533:FGSG_05281
uniprot id: I1RMT4
names: Similarity
messages: Belongs to the PPP phosphatase family.

229533:FGSG 02870
gene id: 229533:FGSG_02870
uniprot id: I1RGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 02273
gene id: 229533:FGSG_02273
uniprot id: V6R0F7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 08729
gene id: 229533:FGSG_08729
uniprot id: I1RWQ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 13715
gene id: 229533:FGSG_13715
uniprot id: I1SA34
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01868
gene id: 229533:FGSG_01868
uniprot id: I1RDZ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

229533:FGSG 01801
gene id: 229533:FGSG_01801
uniprot id: I1RDT5
names: Similarity
messages: Belongs to the glutaminase family.

229533:FGSG 10193
gene id: 229533:FGSG_10193
uniprot id: I1S0G6
names: Similarity
messages: Belongs to the cytochrome b5 family.

229533:FGSG 05523
gene id: 229533:FGSG_05523
uniprot id: I1RNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

229533:FGSG 12726
gene id: 229533:FGSG_12726
uniprot id: I1S7A3
names: Similarity
messages: Belongs to the yippee family.

229533:FGSG 08491
gene id: 229533:FGSG_08491
uniprot id: I1RW37
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Cytoplasm
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Hypophosphorylated form interacts with ATG1 to form the ATG1-ATG13 kinase complex (By similarity). The ATG1-ATG13 complex interacts with the ATG17-ATG29-ATG31 complex through direct interaction with ATG17 (By similarity).
messages: Preautophagosomal structure

229533:FGSG 00467
gene id: 229533:FGSG_00467
uniprot id: I1RAE0
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

229533:FGSG 07639
gene id: 229533:FGSG_07639
uniprot id: I1RTX1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 11032
gene id: 229533:FGSG_11032
uniprot id: I1S2N3
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Cu(2+) ion per subunit.
messages: Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides (By similarity).
messages: Galactose oxidase contains a protein-derived free radical cofactor (By similarity). In the active state, Tyr-313, which is cross-linked to Cys-269 via a thioether bond, is oxidized to a radical and acts with Cu(2+) as a two-electron acceptor in the oxidation reaction. The cross-link is believed to modulate the redox potential of the tyrosyl radical, which is further stabilized by a stacking interaction with Trp-331 in the active site. The post-translational formation of the cross-link is closely linked to the propeptide cleavage event, and both are copper-dependent, autocatalytic processes. The propeptide may act as an intramolecular chaperone, facilitating thioester bond formation and copper binding by positioning of active-site residues, including copper ligands (By similarity).
messages: Monomer.
messages: Secreted

229533:FGSG 09850
gene id: 229533:FGSG_09850
uniprot id: I1RZK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex.
messages: Golgi apparatus membrane
messages: Membrane

229533:FGSG 05318
gene id: 229533:FGSG_05318
uniprot id: I1RMW5
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00578
gene id: 229533:FGSG_00578
uniprot id: I1RAP5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 04194
gene id: 229533:FGSG_04194
uniprot id: V6RAM6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 00845
gene id: 229533:FGSG_00845
uniprot id: I1RBC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

229533:FGSG 01318
gene id: 229533:FGSG_01318
uniprot id: I1RCK0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08082
gene id: 229533:FGSG_08082
uniprot id: I1RV22
names: Function
names: Induction
names: Similarity
messages: Belongs to the acetyltransferase family.
messages: Highly expressed under trichothecene-producing conditions.
messages: Putative acetyltransferase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).

229533:FGSG 10318
gene id: 229533:FGSG_10318
uniprot id: I1S0T1
names: Similarity
messages: Belongs to the amidase family.

229533:FGSG 12725
gene id: 229533:FGSG_12725
uniprot id: I1S7A2
names: Similarity
messages: Belongs to the SEN15 family.

229533:FGSG 08758
gene id: 229533:FGSG_08758
uniprot id: I1RWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 09579
gene id: 229533:FGSG_09579
uniprot id: I1RYW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

229533:FGSG 03929
gene id: 229533:FGSG_03929
uniprot id: I1RJB8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04845
gene id: 229533:FGSG_04845
uniprot id: I1RLN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

229533:FGSG 03080
gene id: 229533:FGSG_03080
uniprot id: I1RH39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

229533:FGSG 02678
gene id: 229533:FGSG_02678
uniprot id: I1RG29
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

229533:FGSG 12282
gene id: 229533:FGSG_12282
uniprot id: I1S611
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07138
gene id: 229533:FGSG_07138
uniprot id: I1RSL5
names: Similarity
messages: Belongs to the UreD family.

229533:FGSG 06562
gene id: 229533:FGSG_06562
uniprot id: I1RR53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

229533:FGSG 11596
gene id: 229533:FGSG_11596
uniprot id: I1S438
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

229533:FGSG 06836
gene id: 229533:FGSG_06836
uniprot id: I1RRU6
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 13224
gene id: 229533:FGSG_13224
uniprot id: I1S8P6
names: Similarity
messages: Belongs to the peptidase S33 family.

229533:FGSG 07360
gene id: 229533:FGSG_07360
uniprot id: I1RT63
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 05956
gene id: 229533:FGSG_05956
uniprot id: I1RPI5
names: Similarity
messages: Belongs to the guanylate kinase family.

229533:FGSG 00168
gene id: 229533:FGSG_00168
uniprot id: I1R9M0
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

229533:FGSG 13865
gene id: 229533:FGSG_13865
uniprot id: I1SAI4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

229533:FGSG 02407
gene id: 229533:FGSG_02407
uniprot id: I1RFD4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

229533:FGSG 04582
gene id: 229533:FGSG_04582
uniprot id: V6R1K4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

229533:FGSG 01360
gene id: 229533:FGSG_01360
uniprot id: V6QWP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 11186
gene id: 229533:FGSG_11186
uniprot id: I1S325
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00192
gene id: 229533:FGSG_00192
uniprot id: I1R9N9
names: Similarity
messages: Belongs to the peptidase S8 family.

229533:FGSG 09147
gene id: 229533:FGSG_09147
uniprot id: I1RXS2
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09434
gene id: 229533:FGSG_09434
uniprot id: I1RYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC19 family.
messages: Nucleus
messages: kinetochore

229533:FGSG 05469
gene id: 229533:FGSG_05469
uniprot id: I1RNA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

229533:FGSG 04593
gene id: 229533:FGSG_04593
uniprot id: I1RL16
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).
messages: Membrane
messages: Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).

229533:FGSG 01871
gene id: 229533:FGSG_01871
uniprot id: I1RE01
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

229533:FGSG 04476
gene id: 229533:FGSG_04476
uniprot id: V6R3X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

229533:FGSG 03171
gene id: 229533:FGSG_03171
uniprot id: I1RHC5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

229533:FGSG 04413
gene id: 229533:FGSG_04413
uniprot id: V6R398
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 01132
gene id: 229533:FGSG_01132
uniprot id: A0A1I9EXS5
uniprot id: Q4INS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

229533:FGSG 02029
gene id: 229533:FGSG_02029
uniprot id: I1REE1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

229533:FGSG 05524
gene id: 229533:FGSG_05524
uniprot id: I1RNE8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06759
gene id: 229533:FGSG_06759
uniprot id: I1RRM7
names: Similarity
messages: Belongs to the RMD1/sif2 family.

229533:FGSG 10963
gene id: 229533:FGSG_10963
uniprot id: I1S2G9
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

229533:FGSG 06137
gene id: 229533:FGSG_06137
uniprot id: I1RQ05
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05368
gene id: 229533:FGSG_05368
uniprot id: I1RN10
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07858
gene id: 229533:FGSG_07858
uniprot id: I1RUG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

229533:FGSG 11289
gene id: 229533:FGSG_11289
uniprot id: I1S3B3
names: Similarity
messages: Belongs to the glutamine synthetase family.

229533:FGSG 06224
gene id: 229533:FGSG_06224
uniprot id: I1RQ85
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

229533:FGSG 03573
gene id: 229533:FGSG_03573
uniprot id: I1RIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 03439
gene id: 229533:FGSG_03439
uniprot id: I1RI19
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

229533:FGSG 03716
gene id: 229533:FGSG_03716
uniprot id: I1RIS2
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07473
gene id: 229533:FGSG_07473
uniprot id: I1RTG9
names: Subcellular Location Annotation
messages: Cell membrane

229533:FGSG 11856
gene id: 229533:FGSG_11856
uniprot id: I1S4T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

229533:FGSG 04976
gene id: 229533:FGSG_04976
uniprot id: I1RM04
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08455
gene id: 229533:FGSG_08455
uniprot id: I1RW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

229533:FGSG 06358
gene id: 229533:FGSG_06358
uniprot id: I1RQL3
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

229533:FGSG 11632
gene id: 229533:FGSG_11632
uniprot id: I1S467
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

229533:FGSG 10043
gene id: 229533:FGSG_10043
uniprot id: I1S029
names: Similarity
messages: Belongs to the glutamine synthetase family.

229533:FGSG 09364
gene id: 229533:FGSG_09364
uniprot id: V6RVE9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 08093
gene id: 229533:FGSG_08093
uniprot id: I1RV31
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 12183
gene id: 229533:FGSG_12183
uniprot id: I1S5R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane
messages: Required for vacuolar protein sorting.

229533:FGSG 03391
gene id: 229533:FGSG_03391
uniprot id: I1RHX5
names: Similarity
messages: Belongs to the group II decarboxylase family.

229533:FGSG 01531
gene id: 229533:FGSG_01531
uniprot id: I1RD42
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

229533:FGSG 08806
gene id: 229533:FGSG_08806
uniprot id: I1RWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

229533:FGSG 07342
gene id: 229533:FGSG_07342
uniprot id: I1RT47
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06791
gene id: 229533:FGSG_06791
uniprot id: I1RRQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LOC1 family.
messages: Component of the 66S pre-ribosomal particle.
messages: Required for efficient assembly and nuclear export of the 60S ribosomal subunit.

229533:FGSG 07432
gene id: 229533:FGSG_07432
uniprot id: I1RTD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

229533:FGSG 10395
gene id: 229533:FGSG_10395
uniprot id: I1S102
names: Similarity
messages: Belongs to the multicopper oxidase family.

229533:FGSG 06060
gene id: 229533:FGSG_06060
uniprot id: I1RPT1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 01574
gene id: 229533:FGSG_01574
uniprot id: I1RD82
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).
messages: Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling (By similarity). Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation (By similarity). Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Forms a complex with ATG9 and ATG23 (By similarity).
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Preautophagosomal structure membrane

229533:FGSG 08561
gene id: 229533:FGSG_08561
uniprot id: I1RW99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

229533:FGSG 05516
gene id: 229533:FGSG_05516
uniprot id: I1RNE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: Mitochondrion

229533:FGSG 05902
gene id: 229533:FGSG_05902
uniprot id: A0A1I9FR14
uniprot id: Q4IA56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

229533:FGSG 04610
gene id: 229533:FGSG_04610
uniprot id: I1RL30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00380
gene id: 229533:FGSG_00380
uniprot id: I1RA56
names: Similarity
messages: Belongs to the peptidase C19 family.

229533:FGSG 11347
gene id: 229533:FGSG_11347
uniprot id: I1S3G5
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

229533:FGSG 01831
gene id: 229533:FGSG_01831
uniprot id: I1RDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-ulmin hydrophobin family.
messages: cell wall

229533:FGSG 08716
gene id: 229533:FGSG_08716
uniprot id: I1RWN8
names: Similarity
messages: Belongs to the RdRP family.

229533:FGSG 00707
gene id: 229533:FGSG_00707
uniprot id: I1RB08
names: Similarity
messages: Belongs to the PHAF1 family.

229533:FGSG 07419
gene id: 229533:FGSG_07419
uniprot id: I1RTB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 01382
gene id: 229533:FGSG_01382
uniprot id: I1RCQ7
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 01898
gene id: 229533:FGSG_01898
uniprot id: I1RE25
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 11488
gene id: 229533:FGSG_11488
uniprot id: I1S3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 00345
gene id: 229533:FGSG_00345
uniprot id: I1RA27
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04137
gene id: 229533:FGSG_04137
uniprot id: I1RJV4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

229533:FGSG 10140
gene id: 229533:FGSG_10140
uniprot id: I1S0B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

229533:FGSG 08577
gene id: 229533:FGSG_08577
uniprot id: I1RWB4
names: Similarity
messages: Belongs to the Rab GDI family.

229533:FGSG 04054
gene id: 229533:FGSG_04054
uniprot id: I1RJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Membrane
messages: Preautophagosomal structure membrane

229533:FGSG 07721
gene id: 229533:FGSG_07721
uniprot id: I1RU42
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

229533:FGSG 10307
gene id: 229533:FGSG_10307
uniprot id: I1S0S0
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

229533:FGSG 05933
gene id: 229533:FGSG_05933
uniprot id: I1RPG4
names: Similarity
messages: Belongs to the SurE nucleotidase family.

229533:FGSG 01381
gene id: 229533:FGSG_01381
uniprot id: I1RCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

229533:FGSG 00161
gene id: 229533:FGSG_00161
uniprot id: I1R9L4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04115
gene id: 229533:FGSG_04115
uniprot id: I1RJT3
names: Similarity
messages: Belongs to the Tom22 family.

229533:FGSG 05274
gene id: 229533:FGSG_05274
uniprot id: I1RMS7
names: Similarity
messages: Belongs to the MAD2 family.

229533:FGSG 12374
gene id: 229533:FGSG_12374
uniprot id: I1S6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

229533:FGSG 10940
gene id: 229533:FGSG_10940
uniprot id: I1S2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules.
messages: nucleolus

229533:FGSG 07758
gene id: 229533:FGSG_07758
uniprot id: I1RU74
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 07441
gene id: 229533:FGSG_07441
uniprot id: I1RTD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 04370
gene id: 229533:FGSG_04370
uniprot id: I1RKG8
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08011
gene id: 229533:FGSG_08011
uniprot id: I1RUV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

229533:FGSG 00921
gene id: 229533:FGSG_00921
uniprot id: I1RBJ6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

229533:FGSG 01582
gene id: 229533:FGSG_01582
uniprot id: I1RD90
names: Similarity
messages: Belongs to the RdRP family.

229533:FGSG 05013
gene id: 229533:FGSG_05013
uniprot id: I1RM36
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 10895
gene id: 229533:FGSG_10895
uniprot id: I1S2A9
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05002
gene id: 229533:FGSG_05002
uniprot id: I1RM25
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05646
gene id: 229533:FGSG_05646
uniprot id: I1RNR1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 12798
gene id: 229533:FGSG_12798
uniprot id: I1S7H5
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02553
gene id: 229533:FGSG_02553
uniprot id: I1RFR6
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

229533:FGSG 11030
gene id: 229533:FGSG_11030
uniprot id: I1S2N1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07453
gene id: 229533:FGSG_07453
uniprot id: I1RTF0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

229533:FGSG 11457
gene id: 229533:FGSG_11457
uniprot id: I1S3R2
names: Similarity
messages: Belongs to the RutC family.

229533:FGSG 01562
gene id: 229533:FGSG_01562
uniprot id: V6QY41
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02696
gene id: 229533:FGSG_02696
uniprot id: I1RG47
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 07540
gene id: 229533:FGSG_07540
uniprot id: I1RTM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 05087
gene id: 229533:FGSG_05087
uniprot id: I1RMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrial acetyl-CoA acetyltransferase that catalyzes both the formation and degradation of acetoacetyl-CoA (By similarity). Seems not to be involved in ergosterol biosynthesis (By similarity). Plays an important role in growth, morphogenesis and maintaining mitochondrial function including the response to oxidative stresses (By similarity).
messages: Mitochondrion

229533:FGSG 03477
gene id: 229533:FGSG_03477
uniprot id: I1RI52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

229533:FGSG 01425
gene id: 229533:FGSG_01425
uniprot id: I1RCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

229533:FGSG 03742
gene id: 229533:FGSG_03742
uniprot id: I1RIU7
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 09909
gene id: 229533:FGSG_09909
uniprot id: I1RZQ7
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09780
gene id: 229533:FGSG_09780
uniprot id: I1RZE1
names: Function
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

229533:FGSG 07625
gene id: 229533:FGSG_07625
uniprot id: I1RTV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.
messages: Belongs to the glycosyl hydrolase 62 family.
messages: Secreted

229533:FGSG 10105
gene id: 229533:FGSG_10105
uniprot id: I1S087
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV10 family.
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.
messages: Endosome membrane
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
messages: Membrane
messages: Vacuole membrane

229533:FGSG 02267
gene id: 229533:FGSG_02267
uniprot id: I1RF05
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07894
gene id: 229533:FGSG_07894
uniprot id: V6RJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 01564
gene id: 229533:FGSG_01564
uniprot id: I1RD74
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06116
gene id: 229533:FGSG_06116
uniprot id: I1RPY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

229533:FGSG 08917
gene id: 229533:FGSG_08917
uniprot id: I1RX67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.

229533:FGSG 00677
gene id: 229533:FGSG_00677
uniprot id: I1RAY2
names: Similarity
messages: Belongs to the protein kinase superfamily.

229533:FGSG 09128
gene id: 229533:FGSG_09128
uniprot id: I1RXQ4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06233
gene id: 229533:FGSG_06233
uniprot id: I1RQ94
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09975
gene id: 229533:FGSG_09975
uniprot id: I1RZW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

229533:FGSG 02400
gene id: 229533:FGSG_02400
uniprot id: I1RFC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

229533:FGSG 10725
gene id: 229533:FGSG_10725
uniprot id: I1S1V3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

229533:FGSG 11561
gene id: 229533:FGSG_11561
uniprot id: I1S409
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 06394
gene id: 229533:FGSG_06394
uniprot id: I1RQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Membrane

229533:FGSG 02147
gene id: 229533:FGSG_02147
uniprot id: I1REQ2
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 07963
gene id: 229533:FGSG_07963
uniprot id: I1RUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

229533:FGSG 07438
gene id: 229533:FGSG_07438
uniprot id: I1RTD5
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

229533:FGSG 03906
gene id: 229533:FGSG_03906
uniprot id: I1RJ98
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 00336
gene id: 229533:FGSG_00336
uniprot id: I1RA19
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

229533:FGSG 03638
gene id: 229533:FGSG_03638
uniprot id: I1RIK1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

229533:FGSG 11366
gene id: 229533:FGSG_11366
uniprot id: I1S3I2
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

229533:FGSG 06069
gene id: 229533:FGSG_06069
uniprot id: I1RPT9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06683
gene id: 229533:FGSG_06683
uniprot id: I1RRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

229533:FGSG 10098
gene id: 229533:FGSG_10098
uniprot id: I1S080
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10242
gene id: 229533:FGSG_10242
uniprot id: V6RY33
names: Similarity
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.

229533:FGSG 06813
gene id: 229533:FGSG_06813
uniprot id: I1RRS6
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

229533:FGSG 12440
gene id: 229533:FGSG_12440
uniprot id: I1S6G9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06161
gene id: 229533:FGSG_06161
uniprot id: I1RQ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

229533:FGSG 11087
gene id: 229533:FGSG_11087
uniprot id: I1S2T4
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 08442
gene id: 229533:FGSG_08442
uniprot id: I1RVZ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

229533:FGSG 11337
gene id: 229533:FGSG_11337
uniprot id: I1S3F7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

229533:FGSG 03481
gene id: 229533:FGSG_03481
uniprot id: I1RI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

229533:FGSG 01890
gene id: 229533:FGSG_01890
uniprot id: I1RE18
names: Similarity
messages: Belongs to the syntaxin family.

229533:FGSG 09124
gene id: 229533:FGSG_09124
uniprot id: I1RXQ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 06122
gene id: 229533:FGSG_06122
uniprot id: I1RPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

229533:FGSG 00633
gene id: 229533:FGSG_00633
uniprot id: I1RAU6
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

229533:FGSG 10906
gene id: 229533:FGSG_10906
uniprot id: I1S2B8
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

229533:FGSG 01446
gene id: 229533:FGSG_01446
uniprot id: I1RCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

229533:FGSG 12028
gene id: 229533:FGSG_12028
uniprot id: I1S5B0
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

229533:FGSG 05821
gene id: 229533:FGSG_05821
uniprot id: I1RP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 09196
gene id: 229533:FGSG_09196
uniprot id: I1RXX0
names: Similarity
messages: Belongs to the isochorismatase family.

229533:FGSG 13103
gene id: 229533:FGSG_13103
uniprot id: I1S8C5
names: Similarity
messages: Belongs to the alkB family.

229533:FGSG 12611
gene id: 229533:FGSG_12611
uniprot id: I1S6Y8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09896
gene id: 229533:FGSG_09896
uniprot id: A0A1I9F3T1
uniprot id: Q4HYR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.
messages: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
messages: Glyoxysome
messages: Homotetramer.

229533:FGSG 08623
gene id: 229533:FGSG_08623
uniprot id: I1RWF6
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 01081
gene id: 229533:FGSG_01081
uniprot id: I1RBY4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

229533:FGSG 04584
gene id: 229533:FGSG_04584
uniprot id: I1RL09
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

229533:FGSG 06053
gene id: 229533:FGSG_06053
uniprot id: I1RPS4
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

229533:FGSG 00510
gene id: 229533:FGSG_00510
uniprot id: I1RAI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

229533:FGSG 05085
gene id: 229533:FGSG_05085
uniprot id: I1RMA0
names: Similarity
messages: Belongs to the SUN family.

229533:FGSG 00102
gene id: 229533:FGSG_00102
uniprot id: I1R9G3
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 13112
gene id: 229533:FGSG_13112
uniprot id: Q4I665
names: Function
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

229533:FGSG 07839
gene id: 229533:FGSG_07839
uniprot id: I1RUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

229533:FGSG 07150
gene id: 229533:FGSG_07150
uniprot id: I1RSM4
names: Similarity
messages: Belongs to the NAD kinase family.

229533:FGSG 02847
gene id: 229533:FGSG_02847
uniprot id: I1RGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

229533:FGSG 05558
gene id: 229533:FGSG_05558
uniprot id: Q4IB50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
messages: Nucleus
messages: The AWS and SET domains are necessary for transcription repression.

229533:FGSG 08352
gene id: 229533:FGSG_08352
uniprot id: I1RVR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

229533:FGSG 12331
gene id: 229533:FGSG_12331
uniprot id: I1S660
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 00960
gene id: 229533:FGSG_00960
uniprot id: I1RBN0
names: Function
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

229533:FGSG 13536
gene id: 229533:FGSG_13536
uniprot id: I1S9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

229533:FGSG 06661
gene id: 229533:FGSG_06661
uniprot id: I1RRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Nucleus

229533:FGSG 08321
gene id: 229533:FGSG_08321
uniprot id: I1RVN8
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 04710
gene id: 229533:FGSG_04710
uniprot id: I1RLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 00049
gene id: 229533:FGSG_00049
uniprot id: I1R9B6
names: Function
names: Similarity
messages: Aminotransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 00621
gene id: 229533:FGSG_00621
uniprot id: I1RAT5
names: Similarity
messages: Belongs to the DNA polymerase type-X family.

229533:FGSG 00310
gene id: 229533:FGSG_00310
uniprot id: I1R9Z3
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

229533:FGSG 06513
gene id: 229533:FGSG_06513
uniprot id: I1RR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

229533:FGSG 02034
gene id: 229533:FGSG_02034
uniprot id: I1REE6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 07225
gene id: 229533:FGSG_07225
uniprot id: I1RSU1
names: Similarity
messages: Belongs to the CBP3 family.

229533:FGSG 09422
gene id: 229533:FGSG_09422
uniprot id: V6RN44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

229533:FGSG 03408
gene id: 229533:FGSG_03408
uniprot id: I1RHY9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

229533:FGSG 07003
gene id: 229533:FGSG_07003
uniprot id: I1RS89
names: Similarity
messages: Belongs to the FMO family.

229533:FGSG 05953
gene id: 229533:FGSG_05953
uniprot id: V6RBG5
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

229533:FGSG 03795
gene id: 229533:FGSG_03795
uniprot id: I1RIZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

229533:FGSG 11357
gene id: 229533:FGSG_11357
uniprot id: I1S3H5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

229533:FGSG 11522
gene id: 229533:FGSG_11522
uniprot id: I1S3X2
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

229533:FGSG 06328
gene id: 229533:FGSG_06328
uniprot id: I1RQI4
names: Similarity
messages: Belongs to the XFP family.

229533:FGSG 01623
gene id: 229533:FGSG_01623
uniprot id: I1RDC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

229533:FGSG 13714
gene id: 229533:FGSG_13714
uniprot id: I1SA33
names: Subunit
messages: Homodimer.

229533:FGSG 08749
gene id: 229533:FGSG_08749
uniprot id: I1RWR9
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00447
gene id: 229533:FGSG_00447
uniprot id: I1RAC0
names: Similarity
messages: Belongs to the acylphosphatase family.

229533:FGSG 06635
gene id: 229533:FGSG_06635
uniprot id: I1RRB7
names: Similarity
messages: Belongs to the RNase Z family.

229533:FGSG 02945
gene id: 229533:FGSG_02945
uniprot id: I1RGS1
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 06195
gene id: 229533:FGSG_06195
uniprot id: I1RQ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

229533:FGSG 04936
gene id: 229533:FGSG_04936
uniprot id: I1RLW6
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

229533:FGSG 09931
gene id: 229533:FGSG_09931
uniprot id: V6RQ28
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

229533:FGSG 01238
gene id: 229533:FGSG_01238
uniprot id: V6QW22
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

229533:FGSG 06166
gene id: 229533:FGSG_06166
uniprot id: I1RQ32
names: Similarity
messages: Belongs to the Rab GDI family.

229533:FGSG 03702
gene id: 229533:FGSG_03702
uniprot id: I1RIR0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 02304
gene id: 229533:FGSG_02304
uniprot id: I1RF38
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

229533:FGSG 06875
gene id: 229533:FGSG_06875
uniprot id: I1RRX5
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

229533:FGSG 10483
gene id: 229533:FGSG_10483
uniprot id: I1S184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

229533:FGSG 04300
gene id: 229533:FGSG_04300
uniprot id: I1RKA3
names: Similarity
messages: Belongs to the peptidase C48 family.

229533:FGSG 00096
gene id: 229533:FGSG_00096
uniprot id: I1R9F8
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

229533:FGSG 02206
gene id: 229533:FGSG_02206
uniprot id: I1REV2
names: Similarity
messages: Belongs to the arginase family.

229533:FGSG 05489
gene id: 229533:FGSG_05489
uniprot id: V6R9Z0
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial large ribosomal subunit.
messages: Mitochondrion

229533:FGSG 10283
gene id: 229533:FGSG_10283
uniprot id: I1S0P7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG2 family.
messages: Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Endoplasmic reticulum membrane
messages: Interacts with ATG18 (By similarity).
messages: Lipid transfer protein required for autophagosome completion and peroxisome degradation and peroxisome degradation (By similarity). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region (By similarity). The latter binding is assisted by an ATG18-PtdIns3P interaction (By similarity). ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Preautophagosomal structure membrane

229533:FGSG 01109
gene id: 229533:FGSG_01109
uniprot id: I1RC10
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 11683
gene id: 229533:FGSG_11683
uniprot id: I1S4B6
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 08009
gene id: 229533:FGSG_08009
uniprot id: I1RUV2
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

229533:FGSG 00880
gene id: 229533:FGSG_00880
uniprot id: I1RBG0
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10199
gene id: 229533:FGSG_10199
uniprot id: I1S0H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

229533:FGSG 01158
gene id: 229533:FGSG_01158
uniprot id: I1RC55
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

229533:FGSG 09628
gene id: 229533:FGSG_09628
uniprot id: A0A1I9FMD6
uniprot id: Q4HZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diphthine synthase family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

229533:FGSG 02968
gene id: 229533:FGSG_02968
uniprot id: I1RGU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

229533:FGSG 01666
gene id: 229533:FGSG_01666
uniprot id: I1RDH0
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 00822
gene id: 229533:FGSG_00822
uniprot id: I1RBB0
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

229533:FGSG 08343
gene id: 229533:FGSG_08343
uniprot id: I1RVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

229533:FGSG 07233
gene id: 229533:FGSG_07233
uniprot id: I1RSU8
names: Similarity
messages: Belongs to the PPP phosphatase family.

229533:FGSG 12029
gene id: 229533:FGSG_12029
uniprot id: I1S5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

229533:FGSG 04458
gene id: 229533:FGSG_04458
uniprot id: I1RKP5
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

229533:FGSG 10835
gene id: 229533:FGSG_10835
uniprot id: I1S251
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 01949
gene id: 229533:FGSG_01949
uniprot id: I1RE72
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

229533:FGSG 02757
gene id: 229533:FGSG_02757
uniprot id: I1RGA0
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

229533:FGSG 02606
gene id: 229533:FGSG_02606
uniprot id: A0A1I9F284
uniprot id: Q4IJK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).
messages: Mitochondrion
messages: Part of the mitochondrial small ribosomal subunit.

229533:FGSG 00904
gene id: 229533:FGSG_00904
uniprot id: I1RBH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

229533:FGSG 01216
gene id: 229533:FGSG_01216
uniprot id: I1RCB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.
messages: Membrane
messages: Nucleus membrane
messages: perinuclear region

229533:FGSG 11249
gene id: 229533:FGSG_11249
uniprot id: I1S379
names: Similarity
messages: Belongs to the peptidase M14 family.

229533:FGSG 00573
gene id: 229533:FGSG_00573
uniprot id: I1RAP1
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09873
gene id: 229533:FGSG_09873
uniprot id: I1RZM4
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

229533:FGSG 09327
gene id: 229533:FGSG_09327
uniprot id: I1RY87
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04777
gene id: 229533:FGSG_04777
uniprot id: I1RLH7
names: Similarity
messages: Belongs to the FAH family.

229533:FGSG 07051
gene id: 229533:FGSG_07051
uniprot id: I1RSD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

229533:FGSG 01119
gene id: 229533:FGSG_01119
uniprot id: I1RC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

229533:FGSG 01751
gene id: 229533:FGSG_01751
uniprot id: I1RDP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

229533:FGSG 11408
gene id: 229533:FGSG_11408
uniprot id: I1S3L9
names: Similarity
messages: Belongs to the tpcK family.

229533:FGSG 11828
gene id: 229533:FGSG_11828
uniprot id: I1S4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

229533:FGSG 05535
gene id: 229533:FGSG_05535
uniprot id: I1RNF9
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

229533:FGSG 01705
gene id: 229533:FGSG_01705
uniprot id: I1RDK3
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

229533:FGSG 08896
gene id: 229533:FGSG_08896
uniprot id: I1RX46
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

229533:FGSG 09584
gene id: 229533:FGSG_09584
uniprot id: V6RPQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

229533:FGSG 00485
gene id: 229533:FGSG_00485
uniprot id: I1RAF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

229533:FGSG 03061
gene id: 229533:FGSG_03061
uniprot id: I1RH23
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

229533:FGSG 09614
gene id: 229533:FGSG_09614
uniprot id: I1RYZ7
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

229533:FGSG 06649
gene id: 229533:FGSG_06649
uniprot id: I1RRD0
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.

229533:FGSG 05610
gene id: 229533:FGSG_05610
uniprot id: I1RNM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

229533:FGSG 04220
gene id: 229533:FGSG_04220
uniprot id: I1RK32
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 09532
gene id: 229533:FGSG_09532
uniprot id: I1RYS3
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.

229533:FGSG 10795
gene id: 229533:FGSG_10795
uniprot id: I1S214
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

229533:FGSG 09686
gene id: 229533:FGSG_09686
uniprot id: I1RZ60
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

229533:FGSG 09157
gene id: 229533:FGSG_09157
uniprot id: I1RXT2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Forms a complex with ATG20 and ATG17 (By similarity).
messages: Membrane
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).
messages: Sorting nexin involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

229533:FGSG 04943
gene id: 229533:FGSG_04943
uniprot id: I1RLX3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 00011
gene id: 229533:FGSG_00011
uniprot id: I1R983
names: Subcellular Location Annotation
messages: Nucleus

229533:FGSG 05512
gene id: 229533:FGSG_05512
uniprot id: Q4IB96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

229533:FGSG 09817
gene id: 229533:FGSG_09817
uniprot id: I1RZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

229533:FGSG 03015
gene id: 229533:FGSG_03015
uniprot id: I1RGY3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 07059
gene id: 229533:FGSG_07059
uniprot id: I1RSE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

229533:FGSG 06919
gene id: 229533:FGSG_06919
uniprot id: I1RS15
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

229533:FGSG 09952
gene id: 229533:FGSG_09952
uniprot id: I1RZU7
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

229533:FGSG 09035
gene id: 229533:FGSG_09035
uniprot id: I1RXG6
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.

229533:FGSG 09365
gene id: 229533:FGSG_09365
uniprot id: I1RYC0
names: Similarity
messages: Belongs to the LOR family.

229533:FGSG 02278
gene id: 229533:FGSG_02278
uniprot id: I1RF15
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 10310
gene id: 229533:FGSG_10310
uniprot id: I1S0S3
names: Subcellular Location Annotation
messages: Membrane

229533:FGSG 04840
gene id: 229533:FGSG_04840
uniprot id: I1RLN0
names: Similarity
messages: Belongs to the peptidase C14B family.

229533:FGSG 07826
gene id: 229533:FGSG_07826
uniprot id: V6RIV7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

229533:FGSG 05478
gene id: 229533:FGSG_05478
uniprot id: A0A1I9FUZ8
uniprot id: Q4IBD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.

229533:FGSG 04619
gene id: 229533:FGSG_04619
uniprot id: I1RL39
names: Similarity
messages: Belongs to the RdRP family.

229533:FGSG 06372
gene id: 229533:FGSG_06372
uniprot id: I1RQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

229533:FGSG 11805
gene id: 229533:FGSG_11805
uniprot id: I1S4N7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the autophagy-specific VPS34 PI3-kinase complex I; and of the VPS34 PI3-kinase complex II (By similarity).
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
messages: Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).
messages: The C-terminal domain called the BARA domain is dispensable for the construction of both VPS34 PI3-kinase complexes, but is specifically required for autophagy through the targeting of complex I to the pre-autophagosomal structure (By similarity).
messages: Vacuole membrane

229533:FGSG 00961
gene id: 229533:FGSG_00961
uniprot id: I1RBN1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

229533:FGSG 02272
gene id: 229533:FGSG_02272
uniprot id: I1RF10
names: Subcellular Location Annotation
messages: Membrane