225848:sps RS20185
gene id: 225848:sps_RS20185
uniprot id: A0A1S6HUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

225848:sps RS27875
gene id: 225848:sps_RS27875
uniprot id: A0A1S6HZ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

225848:sps RS22575
gene id: 225848:sps_RS22575
uniprot id: A0A1S6HVZ2
names: Similarity
messages: Belongs to the P(II) protein family.

225848:sps RS24475
gene id: 225848:sps_RS24475
uniprot id: A0A1S6HX42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

225848:sps RS02775
gene id: 225848:sps_RS02775
uniprot id: A0A1S6HJR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

225848:sps RS13295
gene id: 225848:sps_RS13295
uniprot id: A0A1S6HQQ7
names: Subcellular Location Annotation
messages: Cytoplasm

225848:sps RS25535
gene id: 225848:sps_RS25535
uniprot id: A0A1S6HXM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

225848:sps RS02560
gene id: 225848:sps_RS02560
uniprot id: A0A1S6HJN0
names: Similarity
names: Subunit
messages: Belongs to the glutaredoxin family.
messages: Monomer.

225848:sps RS06650
gene id: 225848:sps_RS06650
uniprot id: A0A1S6HLX0
names: Subcellular Location Annotation
messages: Cytoplasm

225848:sps RS08190
gene id: 225848:sps_RS08190
uniprot id: A0A1S6HMT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

225848:sps RS01800
gene id: 225848:sps_RS01800
uniprot id: A0A1S6HJ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

225848:sps RS15160
gene id: 225848:sps_RS15160
uniprot id: A0A1S6HRS3
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

225848:sps RS16360
gene id: 225848:sps_RS16360
uniprot id: A0A1S6HSF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

225848:sps RS01825
gene id: 225848:sps_RS01825
uniprot id: A0A1S6HJ87
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

225848:sps RS01885
gene id: 225848:sps_RS01885
uniprot id: A0A1S6HJA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

225848:sps RS08330
gene id: 225848:sps_RS08330
uniprot id: A0A1S6HMW7
names: Similarity
messages: Belongs to the YciI family.

225848:sps RS06550
gene id: 225848:sps_RS06550
uniprot id: A0A1S6HLU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

225848:sps RS01920
gene id: 225848:sps_RS01920
uniprot id: A0A1S6HJB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

225848:sps RS01860
gene id: 225848:sps_RS01860
uniprot id: A0A1S6HJ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

225848:sps RS00185
gene id: 225848:sps_RS00185
uniprot id: A0A1S6HID2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

225848:sps RS01900
gene id: 225848:sps_RS01900
uniprot id: A0A1S6HJ92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

225848:sps RS02765
gene id: 225848:sps_RS02765
uniprot id: A0A1S6HJS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

225848:sps RS11660
gene id: 225848:sps_RS11660
uniprot id: A0A1S6HPU4
names: Similarity
messages: Belongs to the P(II) protein family.

225848:sps RS25475
gene id: 225848:sps_RS25475
uniprot id: A0A1S6HXD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

225848:sps RS05670
gene id: 225848:sps_RS05670
uniprot id: A0A1S6HLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

225848:sps RS06710
gene id: 225848:sps_RS06710
uniprot id: A0A1S6HM11
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

225848:sps RS01895
gene id: 225848:sps_RS01895
uniprot id: A0A1S6HJ94
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

225848:sps RS05315
gene id: 225848:sps_RS05315
uniprot id: A0A1S6HL53
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

225848:sps RS19025
gene id: 225848:sps_RS19025
uniprot id: A0A1S6HU09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

225848:sps RS01830
gene id: 225848:sps_RS01830
uniprot id: A0A1S6HJ86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

225848:sps RS12530
gene id: 225848:sps_RS12530
uniprot id: A0A1S6HQD7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

225848:sps RS01845
gene id: 225848:sps_RS01845
uniprot id: A0A1S6HJ84
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

225848:sps RS16265
gene id: 225848:sps_RS16265
uniprot id: A0A1S6HSE7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

225848:sps RS01935
gene id: 225848:sps_RS01935
uniprot id: A0A1S6HJA3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

225848:sps RS01855
gene id: 225848:sps_RS01855
uniprot id: A0A1S6HJ81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.