224914:BME RS03815
gene id: 224914:BME_RS03815
uniprot id: Q8YHN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

224914:BME RS07515
gene id: 224914:BME_RS07515
uniprot id: Q8YFL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

224914:BME RS07725
gene id: 224914:BME_RS07725
uniprot id: Q8YFH2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

224914:BME RS01145
gene id: 224914:BME_RS01145
uniprot id: P67539
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

224914:BME RS10480
gene id: 224914:BME_RS10480
uniprot id: Q8YDW3
names: Function
names: Subunit
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

224914:BME RS03080
gene id: 224914:BME_RS03080
uniprot id: Q8YI27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

224914:BME RS06080
gene id: 224914:BME_RS06080
uniprot id: Q8YGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

224914:BME RS12280
gene id: 224914:BME_RS12280
uniprot id: Q8YCV1
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

224914:BME RS00050
gene id: 224914:BME_RS00050
uniprot id: Q8YJS2
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

224914:BME RS13610
gene id: 224914:BME_RS13610
uniprot id: D0B707
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.

224914:BME RS13155
gene id: 224914:BME_RS13155
uniprot id: Q8YCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

224914:BME RS04525
gene id: 224914:BME_RS04525
uniprot id: Q8YH95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS13490
gene id: 224914:BME_RS13490
uniprot id: Q8YC59
names: Similarity
messages: Belongs to the UPF0173 family.

224914:BME RS04250
gene id: 224914:BME_RS04250
uniprot id: Q8YHF0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

224914:BME RS05955
gene id: 224914:BME_RS05955
uniprot id: Q8YGH6
names: Similarity
messages: Belongs to the UPF0174 family.

224914:BME RS06680
gene id: 224914:BME_RS06680
uniprot id: Q8YG35
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

224914:BME RS12845
gene id: 224914:BME_RS12845
uniprot id: Q8YCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

224914:BME RS09075
gene id: 224914:BME_RS09075
uniprot id: Q8YEP5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

224914:BME RS09830
gene id: 224914:BME_RS09830
uniprot id: Q8YE93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

224914:BME RS06055
gene id: 224914:BME_RS06055
uniprot id: Q8YGF5
names: Similarity
messages: Belongs to the GppA/Ppx family.

224914:BME RS07760
gene id: 224914:BME_RS07760
uniprot id: Q8YFG4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

224914:BME RS13920
gene id: 224914:BME_RS13920
uniprot id: Q8YBX4
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS02370
gene id: 224914:BME_RS02370
uniprot id: Q8YIH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

224914:BME RS16800
gene id: 224914:BME_RS16800
uniprot id: Q8YEL5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

224914:BME RS12580
gene id: 224914:BME_RS12580
uniprot id: Q8YCN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).

224914:BME RS10730
gene id: 224914:BME_RS10730
uniprot id: Q8YDR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

224914:BME RS07580
gene id: 224914:BME_RS07580
uniprot id: Q8YFK1
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

224914:BME RS08635
gene id: 224914:BME_RS08635
uniprot id: Q8YEY9
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

224914:BME RS13335
gene id: 224914:BME_RS13335
uniprot id: Q8YC87
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

224914:BME RS01160
gene id: 224914:BME_RS01160
uniprot id: Q8YJ50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

224914:BME RS03895
gene id: 224914:BME_RS03895
uniprot id: P66350
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

224914:BME RS10745
gene id: 224914:BME_RS10745
uniprot id: Q8YDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

224914:BME RS03290
gene id: 224914:BME_RS03290
uniprot id: Q8YHY0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS00400
gene id: 224914:BME_RS00400
uniprot id: Q8YJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

224914:BME RS15300
gene id: 224914:BME_RS15300
uniprot id: Q8YB49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

224914:BME RS00795
gene id: 224914:BME_RS00795
uniprot id: Q8YJB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Cell inner membrane
messages: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
messages: Homohexamer. Forms a ring that surrounds DNA (By similarity).

224914:BME RS01440
gene id: 224914:BME_RS01440
uniprot id: P52558
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

224914:BME RS02655
gene id: 224914:BME_RS02655
uniprot id: Q8YIB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

224914:BME RS01900
gene id: 224914:BME_RS01900
uniprot id: Q8YIQ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

224914:BME RS01475
gene id: 224914:BME_RS01475
uniprot id: Q8YIY5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

224914:BME RS04830
gene id: 224914:BME_RS04830
uniprot id: Q8YH35
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS06230
gene id: 224914:BME_RS06230
uniprot id: Q8YGC2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

224914:BME RS13645
gene id: 224914:BME_RS13645
uniprot id: Q8YC29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

224914:BME RS03875
gene id: 224914:BME_RS03875
uniprot id: Q8YHM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

224914:BME RS02000
gene id: 224914:BME_RS02000
uniprot id: Q8YIP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS00790
gene id: 224914:BME_RS00790
uniprot id: Q8YJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

224914:BME RS13650
gene id: 224914:BME_RS13650
uniprot id: P49944
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

224914:BME RS01190
gene id: 224914:BME_RS01190
uniprot id: Q8YJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

224914:BME RS01095
gene id: 224914:BME_RS01095
uniprot id: Q8YJ64
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

224914:BME RS09890
gene id: 224914:BME_RS09890
uniprot id: Q8YE79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

224914:BME RS05965
gene id: 224914:BME_RS05965
uniprot id: Q8YGH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

224914:BME RS05215
gene id: 224914:BME_RS05215
uniprot id: Q8YGW3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

224914:BME RS03320
gene id: 224914:BME_RS03320
uniprot id: Q8YHX5
names: Similarity
messages: Belongs to the UPF0053 family. Hemolysin C subfamily.

224914:BME RS06515
gene id: 224914:BME_RS06515
uniprot id: Q8YG65
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the RelA/SpoT family.
messages: Cells show morphological abnormalities such as branching and swelling forms during vegetative growth. It is unable to persist during stationary phase, presumably because of nutrient limitation occurring during this growth phase. It shows an important growth defect in human HeLa cells and in ovine macrophages MOCL3. At four weeks post infection the number of viable bacteria (deletion mutant) in mouse spleen is markedly reduced compared to the wild-type. The deletion mutant shows very low levels or absence of VirB at all time points of growth.
messages: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. It is necessary for persistence in mice, essential for intracellular growth of Brucella and required for expression of the type IV secretion system VirB and therefore plays a role in adaptation of Brucella to its intracellular host environment.

224914:BME RS03755
gene id: 224914:BME_RS03755
uniprot id: Q8GH23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity).
messages: With S4 and S5 plays an important role in translational accuracy.

224914:BME RS09345
gene id: 224914:BME_RS09345
uniprot id: Q8YEJ3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS14680
gene id: 224914:BME_RS14680
uniprot id: Q8YBI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS04415
gene id: 224914:BME_RS04415
uniprot id: P63814
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

224914:BME RS11845
gene id: 224914:BME_RS11845
uniprot id: Q8YD37
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS05630
gene id: 224914:BME_RS05630
uniprot id: Q8YGN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

224914:BME RS08220
gene id: 224914:BME_RS08220
uniprot id: Q7CNT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

224914:BME RS11355
gene id: 224914:BME_RS11355
uniprot id: Q8YDE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS07960
gene id: 224914:BME_RS07960
uniprot id: Q8YFC4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS03935
gene id: 224914:BME_RS03935
uniprot id: P67008
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

224914:BME RS11545
gene id: 224914:BME_RS11545
uniprot id: P66242
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

224914:BME RS12715
gene id: 224914:BME_RS12715
uniprot id: Q8YCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

224914:BME RS07140
gene id: 224914:BME_RS07140
uniprot id: Q8YFU3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

224914:BME RS11535
gene id: 224914:BME_RS11535
uniprot id: Q8YDA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

224914:BME RS14800
gene id: 224914:BME_RS14800
uniprot id: Q8YBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

224914:BME RS12615
gene id: 224914:BME_RS12615
uniprot id: Q8YCN1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

224914:BME RS11735
gene id: 224914:BME_RS11735
uniprot id: Q8YD64
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

224914:BME RS15475
gene id: 224914:BME_RS15475
uniprot id: Q8YB15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

224914:BME RS06380
gene id: 224914:BME_RS06380
uniprot id: Q8YG94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

224914:BME RS08090
gene id: 224914:BME_RS08090
uniprot id: Q8YF97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

224914:BME RS14390
gene id: 224914:BME_RS14390
uniprot id: Q8YBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm
messages: Probably part of an ABC transporter complex that could be involved in peptide import.
messages: The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859).

224914:BME RS01615
gene id: 224914:BME_RS01615
uniprot id: P66742
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

224914:BME RS05890
gene id: 224914:BME_RS05890
uniprot id: Q8YGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family. Type 2 subfamily.
messages: Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
messages: Cell membrane
messages: Interacts with CtaB.

224914:BME RS03700
gene id: 224914:BME_RS03700
uniprot id: P64024
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

224914:BME RS04370
gene id: 224914:BME_RS04370
uniprot id: Q8YHC6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

224914:BME RS00880
gene id: 224914:BME_RS00880
uniprot id: Q8YJA1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

224914:BME RS13770
gene id: 224914:BME_RS13770
uniprot id: Q8YC05
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

224914:BME RS00460
gene id: 224914:BME_RS00460
uniprot id: Q8YJI4
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

224914:BME RS09750
gene id: 224914:BME_RS09750
uniprot id: Q8YEA9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

224914:BME RS01585
gene id: 224914:BME_RS01585
uniprot id: Q8YIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

224914:BME RS12820
gene id: 224914:BME_RS12820
uniprot id: Q8YCI8
names: Similarity
messages: Belongs to the RutC family.

224914:BME RS00735
gene id: 224914:BME_RS00735
uniprot id: Q8YJD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

224914:BME RS15710
gene id: 224914:BME_RS15710
uniprot id: Q8YAW8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

224914:BME RS00200
gene id: 224914:BME_RS00200
uniprot id: Q8YJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family. Hemolysin C subfamily.
messages: Membrane

224914:BME RS11220
gene id: 224914:BME_RS11220
uniprot id: Q8YDG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm
messages: Probably part of an ABC transporter complex that could be involved in peptide import.
messages: The complex is composed of two ATP-binding proteins (BMEII0205 and BMEII0206), two transmembrane proteins (BMEII0207/BMEII0208 and BMEII0209) and a solute-binding protein (BMEII0210).

224914:BME RS12935
gene id: 224914:BME_RS12935
uniprot id: P62921
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

224914:BME RS09940
gene id: 224914:BME_RS09940
uniprot id: P66265
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

224914:BME RS14635
gene id: 224914:BME_RS14635
uniprot id: Q8YBJ1
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS09465
gene id: 224914:BME_RS09465
uniprot id: Q8YEG8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

224914:BME RS09910
gene id: 224914:BME_RS09910
uniprot id: Q8YE76
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

224914:BME RS11455
gene id: 224914:BME_RS11455
uniprot id: Q8YDB9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

224914:BME RS15055
gene id: 224914:BME_RS15055
uniprot id: Q8YB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

224914:BME RS09455
gene id: 224914:BME_RS09455
uniprot id: Q8YEH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

224914:BME RS13085
gene id: 224914:BME_RS13085
uniprot id: Q8YCE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of a binding-protein-dependent transport system for a sugar.
messages: Periplasm

224914:BME RS11500
gene id: 224914:BME_RS11500
uniprot id: Q8YDB0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

224914:BME RS09450
gene id: 224914:BME_RS09450
uniprot id: Q8YEH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS00475
gene id: 224914:BME_RS00475
uniprot id: Q8YJI0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

224914:BME RS13545
gene id: 224914:BME_RS13545
uniprot id: Q8YC50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

224914:BME RS12030
gene id: 224914:BME_RS12030
uniprot id: Q8YD01
names: Similarity
messages: Belongs to the surface antigen msp4 family.

224914:BME RS11115
gene id: 224914:BME_RS11115
uniprot id: Q8YDI8
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

224914:BME RS04150
gene id: 224914:BME_RS04150
uniprot id: P0A3P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

224914:BME RS06510
gene id: 224914:BME_RS06510
uniprot id: P65910
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

224914:BME RS02355
gene id: 224914:BME_RS02355
uniprot id: Q8YIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

224914:BME RS01505
gene id: 224914:BME_RS01505
uniprot id: Q8YIX9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

224914:BME RS14880
gene id: 224914:BME_RS14880
uniprot id: Q8YBD5
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 copper ion per subunit.
messages: Periplasm

224914:BME RS05705
gene id: 224914:BME_RS05705
uniprot id: Q8YGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

224914:BME RS04555
gene id: 224914:BME_RS04555
uniprot id: Q8YH89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

224914:BME RS05800
gene id: 224914:BME_RS05800
uniprot id: Q8YGK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

224914:BME RS10100
gene id: 224914:BME_RS10100
uniprot id: P64351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

224914:BME RS09540
gene id: 224914:BME_RS09540
uniprot id: Q8YEF2
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

224914:BME RS04420
gene id: 224914:BME_RS04420
uniprot id: Q8YHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: Periplasm

224914:BME RS00520
gene id: 224914:BME_RS00520
uniprot id: Q8YJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

224914:BME RS03490
gene id: 224914:BME_RS03490
uniprot id: Q8YHU2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

224914:BME RS00030
gene id: 224914:BME_RS00030
uniprot id: Q8YJS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

224914:BME RS07160
gene id: 224914:BME_RS07160
uniprot id: Q8YFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

224914:BME RS12680
gene id: 224914:BME_RS12680
uniprot id: Q8YCL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

224914:BME RS05235
gene id: 224914:BME_RS05235
uniprot id: Q8YGV9
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

224914:BME RS05675
gene id: 224914:BME_RS05675
uniprot id: Q8YGM6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

224914:BME RS04650
gene id: 224914:BME_RS04650
uniprot id: Q8YH70
names: Similarity
messages: Belongs to the DEAD box helicase family.

224914:BME RS05100
gene id: 224914:BME_RS05100
uniprot id: Q8YGY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

224914:BME RS11275
gene id: 224914:BME_RS11275
uniprot id: Q8YDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS05275
gene id: 224914:BME_RS05275
uniprot id: Q8YGV2
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

224914:BME RS04120
gene id: 224914:BME_RS04120
uniprot id: Q8YHH4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

224914:BME RS13760
gene id: 224914:BME_RS13760
uniprot id: Q8YC08
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

224914:BME RS11205
gene id: 224914:BME_RS11205
uniprot id: Q8YDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BMEII0205 and BMEII0206), two transmembrane proteins (BMEII0207/BMEII0208 and BMEII0209) and a solute-binding protein (BMEII0210).

224914:BME RS10220
gene id: 224914:BME_RS10220
uniprot id: Q8YE14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

224914:BME RS05650
gene id: 224914:BME_RS05650
uniprot id: Q8YGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

224914:BME RS07590
gene id: 224914:BME_RS07590
uniprot id: Q8YFJ9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

224914:BME RS12235
gene id: 224914:BME_RS12235
uniprot id: Q8YCW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224914:BME RS02120
gene id: 224914:BME_RS02120
uniprot id: Q7CNV1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes.

224914:BME RS05570
gene id: 224914:BME_RS05570
uniprot id: P63450
names: Function
names: PTM
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).
messages: Cytoplasm

224914:BME RS09645
gene id: 224914:BME_RS09645
uniprot id: Q8YED0
names: Similarity
messages: Belongs to the peptidase M17 family.

224914:BME RS14850
gene id: 224914:BME_RS14850
uniprot id: Q8YBE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

224914:BME RS12770
gene id: 224914:BME_RS12770
uniprot id: Q8YCK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
messages: Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).
messages: Homodimer or monomer when oxidized or reduced, respectively.
messages: chloroplast

224914:BME RS07365
gene id: 224914:BME_RS07365
uniprot id: Q8YFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

224914:BME RS13240
gene id: 224914:BME_RS13240
uniprot id: Q8YCA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

224914:BME RS07930
gene id: 224914:BME_RS07930
uniprot id: Q8YFD1
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

224914:BME RS09740
gene id: 224914:BME_RS09740
uniprot id: Q8YEB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

224914:BME RS10445
gene id: 224914:BME_RS10445
uniprot id: Q8YDX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity).

224914:BME RS03605
gene id: 224914:BME_RS03605
uniprot id: Q8YHS1
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

224914:BME RS13015
gene id: 224914:BME_RS13015
uniprot id: Q8YCF2
names: Function
names: Similarity
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.

224914:BME RS04720
gene id: 224914:BME_RS04720
uniprot id: Q8YH55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

224914:BME RS14990
gene id: 224914:BME_RS14990
uniprot id: Q8YBB2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Binds 1 Cu(+) ion.
messages: Homotrimer.
messages: Periplasm

224914:BME RS01235
gene id: 224914:BME_RS01235
uniprot id: P63660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

224914:BME RS11190
gene id: 224914:BME_RS11190
uniprot id: Q8YDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS13575
gene id: 224914:BME_RS13575
uniprot id: Q8YC44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

224914:BME RS10345
gene id: 224914:BME_RS10345
uniprot id: P0C537
names: Subcellular Location Annotation
messages: Cell membrane

224914:BME RS09620
gene id: 224914:BME_RS09620
uniprot id: P66501
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

224914:BME RS13840
gene id: 224914:BME_RS13840
uniprot id: Q8YBZ0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

224914:BME RS09415
gene id: 224914:BME_RS09415
uniprot id: Q8YEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Membrane

224914:BME RS04265
gene id: 224914:BME_RS04265
uniprot id: Q8YHE7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

224914:BME RS05240
gene id: 224914:BME_RS05240
uniprot id: Q8YGV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

224914:BME RS02185
gene id: 224914:BME_RS02185
uniprot id: Q8YIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

224914:BME RS10115
gene id: 224914:BME_RS10115
uniprot id: Q8YE35
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

224914:BME RS11045
gene id: 224914:BME_RS11045
uniprot id: Q8YDJ6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

224914:BME RS02335
gene id: 224914:BME_RS02335
uniprot id: P63850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

224914:BME RS13425
gene id: 224914:BME_RS13425
uniprot id: P66215
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

224914:BME RS06655
gene id: 224914:BME_RS06655
uniprot id: Q8YG40
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS08710
gene id: 224914:BME_RS08710
uniprot id: Q8YEX3
names: Function
names: Similarity
names: Subunit
messages: APS kinase catalyzes the synthesis of activated sulfate.
messages: Belongs to the APS kinase family.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Catalyzes the synthesis of activated sulfate.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Proposed to provide activated sulfate for transfer to Nod factor. ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity.
messages: Sulfate-activating enzymes, NodP and NodQ, may be physically associated.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

224914:BME RS10340
gene id: 224914:BME_RS10340
uniprot id: Q8YDZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbL/VirB6 family.
messages: Cell inner membrane

224914:BME RS10995
gene id: 224914:BME_RS10995
uniprot id: Q8YDK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

224914:BME RS07475
gene id: 224914:BME_RS07475
uniprot id: Q8YFM3
names: Similarity
messages: Belongs to the TlyA family.

224914:BME RS05765
gene id: 224914:BME_RS05765
uniprot id: Q8YGK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS01875
gene id: 224914:BME_RS01875
uniprot id: Q8YIR2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

224914:BME RS07985
gene id: 224914:BME_RS07985
uniprot id: Q8YFB8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

224914:BME RS14775
gene id: 224914:BME_RS14775
uniprot id: Q8YBF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS03760
gene id: 224914:BME_RS03760
uniprot id: Q8YHP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

224914:BME RS00925
gene id: 224914:BME_RS00925
uniprot id: Q8YJ91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

224914:BME RS01375
gene id: 224914:BME_RS01375
uniprot id: Q8YJ04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

224914:BME RS09030
gene id: 224914:BME_RS09030
uniprot id: Q8YEQ5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

224914:BME RS03020
gene id: 224914:BME_RS03020
uniprot id: Q8YI40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224914:BME RS13270
gene id: 224914:BME_RS13270
uniprot id: Q8YCA0
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS08620
gene id: 224914:BME_RS08620
uniprot id: Q8YEZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

224914:BME RS07685
gene id: 224914:BME_RS07685
uniprot id: P0A4D9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

224914:BME RS01610
gene id: 224914:BME_RS01610
uniprot id: Q8YIV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

224914:BME RS02550
gene id: 224914:BME_RS02550
uniprot id: P64271
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

224914:BME RS10860
gene id: 224914:BME_RS10860
uniprot id: Q8YDN6
names: Similarity
messages: Belongs to the HpcH/HpaI aldolase family.

224914:BME RS15315
gene id: 224914:BME_RS15315
uniprot id: Q8YB47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

224914:BME RS12685
gene id: 224914:BME_RS12685
uniprot id: Q8YCL7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

224914:BME RS01265
gene id: 224914:BME_RS01265
uniprot id: Q8YJ27
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS10125
gene id: 224914:BME_RS10125
uniprot id: P64366
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

224914:BME RS01560
gene id: 224914:BME_RS01560
uniprot id: P66183
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

224914:BME RS04360
gene id: 224914:BME_RS04360
uniprot id: Q8YHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

224914:BME RS13870
gene id: 224914:BME_RS13870
uniprot id: Q8YBY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS14135
gene id: 224914:BME_RS14135
uniprot id: Q8YBT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

224914:BME RS14190
gene id: 224914:BME_RS14190
uniprot id: Q8YBS0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

224914:BME RS08225
gene id: 224914:BME_RS08225
uniprot id: Q8YF72
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

224914:BME RS07470
gene id: 224914:BME_RS07470
uniprot id: Q8YFM4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

224914:BME RS13430
gene id: 224914:BME_RS13430
uniprot id: Q8YC70
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS08645
gene id: 224914:BME_RS08645
uniprot id: Q8YEY7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

224914:BME RS06360
gene id: 224914:BME_RS06360
uniprot id: Q8YG97
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS07425
gene id: 224914:BME_RS07425
uniprot id: Q8YFN3
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS14600
gene id: 224914:BME_RS14600
uniprot id: Q8YBK0
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

224914:BME RS03795
gene id: 224914:BME_RS03795
uniprot id: Q8YHN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

224914:BME RS02040
gene id: 224914:BME_RS02040
uniprot id: Q8YIN4
names: Cofactor
messages: Can also use Mn(2+) ion.

224914:BME RS15720
gene id: 224914:BME_RS15720
uniprot id: Q8YAW6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS01255
gene id: 224914:BME_RS01255
uniprot id: Q8YJ29
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways.
messages: Belongs to the proline racemase family.
messages: Homodimer.
messages: Inhibited by iodoacetate, iodoacetamide and by high amounts (10 mM) of pyrrole-2-carboxylic acid (PYC). Not inhibited by PYC at 1 mM.
messages: This enzyme does not require pyridoxal phosphate (PLP) as a cofactor.

224914:BME RS03200
gene id: 224914:BME_RS03200
uniprot id: Q8YI02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

224914:BME RS02880
gene id: 224914:BME_RS02880
uniprot id: Q8YI66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

224914:BME RS04245
gene id: 224914:BME_RS04245
uniprot id: Q8YHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

224914:BME RS06665
gene id: 224914:BME_RS06665
uniprot id: Q8YG38
names: Similarity
messages: Belongs to the peptidase M1 family.

224914:BME RS02395
gene id: 224914:BME_RS02395
uniprot id: Q8YIG5
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

224914:BME RS06245
gene id: 224914:BME_RS06245
uniprot id: Q8YGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

224914:BME RS12660
gene id: 224914:BME_RS12660
uniprot id: Q8YCM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS01815
gene id: 224914:BME_RS01815
uniprot id: Q8YIS2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

224914:BME RS02890
gene id: 224914:BME_RS02890
uniprot id: Q8YI64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

224914:BME RS07545
gene id: 224914:BME_RS07545
uniprot id: Q8YFL0
names: Subcellular Location Annotation
messages: Cytoplasm

224914:BME RS11695
gene id: 224914:BME_RS11695
uniprot id: P0A4R0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

224914:BME RS11955
gene id: 224914:BME_RS11955
uniprot id: Q8YD16
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS02665
gene id: 224914:BME_RS02665
uniprot id: Q8YIB0
names: Similarity
messages: Belongs to the UPF0260 family.

224914:BME RS10765
gene id: 224914:BME_RS10765
uniprot id: Q8YDQ6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS15485
gene id: 224914:BME_RS15485
uniprot id: Q8YB13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

224914:BME RS10050
gene id: 224914:BME_RS10050
uniprot id: Q8YE49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

224914:BME RS09085
gene id: 224914:BME_RS09085
uniprot id: Q8YEP3
names: Similarity
messages: Belongs to the PhzF family.

224914:BME RS14525
gene id: 224914:BME_RS14525
uniprot id: Q8YBL4
names: Similarity
messages: Belongs to the UPF0423 family.

224914:BME RS07720
gene id: 224914:BME_RS07720
uniprot id: Q8YFH3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

224914:BME RS13570
gene id: 224914:BME_RS13570
uniprot id: Q8YC45
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

224914:BME RS01325
gene id: 224914:BME_RS01325
uniprot id: P66205
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

224914:BME RS10960
gene id: 224914:BME_RS10960
uniprot id: Q8YDL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

224914:BME RS15445
gene id: 224914:BME_RS15445
uniprot id: Q8YB21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

224914:BME RS00645
gene id: 224914:BME_RS00645
uniprot id: Q8YJE7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

224914:BME RS00495
gene id: 224914:BME_RS00495
uniprot id: Q8YJH6
names: Similarity
messages: Belongs to the asparaginase 1 family.

224914:BME RS08760
gene id: 224914:BME_RS08760
uniprot id: Q8YEW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

224914:BME RS02800
gene id: 224914:BME_RS02800
uniprot id: Q8YI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

224914:BME RS02635
gene id: 224914:BME_RS02635
uniprot id: Q8YIB8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

224914:BME RS04430
gene id: 224914:BME_RS04430
uniprot id: P65948
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

224914:BME RS14205
gene id: 224914:BME_RS14205
uniprot id: P65447
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.

224914:BME RS15665
gene id: 224914:BME_RS15665
uniprot id: Q8YAX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

224914:BME RS13110
gene id: 224914:BME_RS13110
uniprot id: Q8YCD6
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS06695
gene id: 224914:BME_RS06695
uniprot id: Q8YG32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
messages: Periplasm

224914:BME RS06540
gene id: 224914:BME_RS06540
uniprot id: Q8YG60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

224914:BME RS11895
gene id: 224914:BME_RS11895
uniprot id: Q8YD27
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S12 family.
messages: Homodimer.
messages: Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
messages: Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate.

224914:BME RS00820
gene id: 224914:BME_RS00820
uniprot id: Q8YJB3
names: Similarity
messages: Belongs to the YciI family.

224914:BME RS15195
gene id: 224914:BME_RS15195
uniprot id: Q8YB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

224914:BME RS10320
gene id: 224914:BME_RS10320
uniprot id: Q9RPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PtlA family.
messages: Cell membrane

224914:BME RS01690
gene id: 224914:BME_RS01690
uniprot id: Q8YIU5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

224914:BME RS02615
gene id: 224914:BME_RS02615
uniprot id: Q8YIC2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

224914:BME RS07355
gene id: 224914:BME_RS07355
uniprot id: P65217
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

224914:BME RS04655
gene id: 224914:BME_RS04655
uniprot id: Q8YH69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

224914:BME RS02405
gene id: 224914:BME_RS02405
uniprot id: Q8YIG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

224914:BME RS13485
gene id: 224914:BME_RS13485
uniprot id: Q8YC60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

224914:BME RS10185
gene id: 224914:BME_RS10185
uniprot id: Q8YE20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

224914:BME RS09725
gene id: 224914:BME_RS09725
uniprot id: Q8YEB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

224914:BME RS00415
gene id: 224914:BME_RS00415
uniprot id: Q8YJJ4
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS15080
gene id: 224914:BME_RS15080
uniprot id: Q8YB94
names: Similarity
messages: Belongs to the DapA family.

224914:BME RS15505
gene id: 224914:BME_RS15505
uniprot id: Q8YB09
names: Similarity
messages: Belongs to the hyi family.

224914:BME RS14865
gene id: 224914:BME_RS14865
uniprot id: Q8YBD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS11610
gene id: 224914:BME_RS11610
uniprot id: Q8YD88
names: Similarity
messages: Belongs to the amidase family.

224914:BME RS04115
gene id: 224914:BME_RS04115
uniprot id: P64048
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

224914:BME RS09745
gene id: 224914:BME_RS09745
uniprot id: P67212
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

224914:BME RS01015
gene id: 224914:BME_RS01015
uniprot id: Q8YJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

224914:BME RS05940
gene id: 224914:BME_RS05940
uniprot id: Q8YGH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

224914:BME RS01170
gene id: 224914:BME_RS01170
uniprot id: Q8YJ48
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

224914:BME RS06075
gene id: 224914:BME_RS06075
uniprot id: Q8YGF1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS05985
gene id: 224914:BME_RS05985
uniprot id: Q8YGH0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

224914:BME RS13465
gene id: 224914:BME_RS13465
uniprot id: Q8YC64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

224914:BME RS02565
gene id: 224914:BME_RS02565
uniprot id: Q8YID3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

224914:BME RS01230
gene id: 224914:BME_RS01230
uniprot id: Q8YJ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

224914:BME RS10475
gene id: 224914:BME_RS10475
uniprot id: Q8YDW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

224914:BME RS09410
gene id: 224914:BME_RS09410
uniprot id: Q8YEH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

224914:BME RS01300
gene id: 224914:BME_RS01300
uniprot id: Q8YJ19
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03075
gene id: 224914:BME_RS03075
uniprot id: Q8YI28
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

224914:BME RS04665
gene id: 224914:BME_RS04665
uniprot id: Q8YH68
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

224914:BME RS05655
gene id: 224914:BME_RS05655
uniprot id: Q8YGN0
names: Similarity
messages: Belongs to the BolA/IbaG family.

224914:BME RS00570
gene id: 224914:BME_RS00570
uniprot id: Q8YJG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

224914:BME RS12695
gene id: 224914:BME_RS12695
uniprot id: Q8YCL5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS14825
gene id: 224914:BME_RS14825
uniprot id: Q8YBE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

224914:BME RS01040
gene id: 224914:BME_RS01040
uniprot id: P67516
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

224914:BME RS14395
gene id: 224914:BME_RS14395
uniprot id: Q8YBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859).

224914:BME RS05580
gene id: 224914:BME_RS05580
uniprot id: Q8YGP5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

224914:BME RS10945
gene id: 224914:BME_RS10945
uniprot id: Q8YDL7
names: Caution
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Inactivation of the ftcR gene down-regulates the activity of the fliF promoter region and the production of both flgE and fliC proteins during vegetative growth or during macrophage infection. This mutant also lacks the flagellar structures under growth conditions in which the wild-type strain is flagellated. The mutant is not attenuated in cellular infection models but exhibits a marked virulence defect after 4 weeks or more of infection in mice.
messages: Lacks the conserved Asp residue in position 50 usually required for phosphorylation. The Glu residue in position 50 may mimic constitutive phosphorylation and allow FtcR to bypass the requirement for phosphorylation.
messages: Required for transcription of the fliF gene during vegetative and intracellular growth and for production of the two flagellar components flgE and fliC during vegetative growth. Specifically binds to the fliF promoter region. Could mediate the action of VjbR on flagellar gene expression.
messages: There is no cognate histidine kinase partner identified so far for FtcR.

224914:BME RS11410
gene id: 224914:BME_RS11410
uniprot id: Q8YDC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

224914:BME RS03965
gene id: 224914:BME_RS03965
uniprot id: P63631
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

224914:BME RS10705
gene id: 224914:BME_RS10705
uniprot id: Q8YDR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (Probable).
messages: The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109).

224914:BME RS10395
gene id: 224914:BME_RS10395
uniprot id: Q8YDY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
messages: Homotetramer.

224914:BME RS03840
gene id: 224914:BME_RS03840
uniprot id: Q8YHM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

224914:BME RS11850
gene id: 224914:BME_RS11850
uniprot id: Q8YD36
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS01295
gene id: 224914:BME_RS01295
uniprot id: Q8YJ20
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

224914:BME RS08290
gene id: 224914:BME_RS08290
uniprot id: P65452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

224914:BME RS04215
gene id: 224914:BME_RS04215
uniprot id: Q8YHF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

224914:BME RS04140
gene id: 224914:BME_RS04140
uniprot id: Q8YHH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane

224914:BME RS06375
gene id: 224914:BME_RS06375
uniprot id: P65680
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

224914:BME RS05420
gene id: 224914:BME_RS05420
uniprot id: P66879
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

224914:BME RS00900
gene id: 224914:BME_RS00900
uniprot id: Q8YJ97
names: Similarity
messages: Belongs to the aspartokinase family.

224914:BME RS13415
gene id: 224914:BME_RS13415
uniprot id: Q8YC73
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS (By similarity).
messages: Interacts with DivL, PleC, DivJ and PdhS.

224914:BME RS11605
gene id: 224914:BME_RS11605
uniprot id: Q8YD89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

224914:BME RS03045
gene id: 224914:BME_RS03045
uniprot id: Q8YI34
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

224914:BME RS03175
gene id: 224914:BME_RS03175
uniprot id: Q8YI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

224914:BME RS03790
gene id: 224914:BME_RS03790
uniprot id: Q8YHN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

224914:BME RS07350
gene id: 224914:BME_RS07350
uniprot id: Q8YFQ2
names: Similarity
messages: Belongs to the peptidase U62 family.

224914:BME RS08965
gene id: 224914:BME_RS08965
uniprot id: Q8YER8
names: Similarity
messages: Belongs to the YkuD family.

224914:BME RS11960
gene id: 224914:BME_RS11960
uniprot id: Q8YD15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

224914:BME RS12090
gene id: 224914:BME_RS12090
uniprot id: Q8YCY9
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

224914:BME RS11025
gene id: 224914:BME_RS11025
uniprot id: Q8YDK0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

224914:BME RS09170
gene id: 224914:BME_RS09170
uniprot id: Q8YEM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

224914:BME RS07100
gene id: 224914:BME_RS07100
uniprot id: F8WJX9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS11810
gene id: 224914:BME_RS11810
uniprot id: P66514
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

224914:BME RS14500
gene id: 224914:BME_RS14500
uniprot id: Q8YBL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

224914:BME RS01625
gene id: 224914:BME_RS01625
uniprot id: Q8YIV4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

224914:BME RS09835
gene id: 224914:BME_RS09835
uniprot id: P63361
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

224914:BME RS02065
gene id: 224914:BME_RS02065
uniprot id: Q8YIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS12210
gene id: 224914:BME_RS12210
uniprot id: P65275
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

224914:BME RS11460
gene id: 224914:BME_RS11460
uniprot id: Q8YDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

224914:BME RS04270
gene id: 224914:BME_RS04270
uniprot id: Q8YHE6
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

224914:BME RS15490
gene id: 224914:BME_RS15490
uniprot id: Q8YB12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

224914:BME RS11975
gene id: 224914:BME_RS11975
uniprot id: Q8YD12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

224914:BME RS06495
gene id: 224914:BME_RS06495
uniprot id: Q8YG69
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS05780
gene id: 224914:BME_RS05780
uniprot id: Q8YGK5
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

224914:BME RS05875
gene id: 224914:BME_RS05875
uniprot id: Q8YGJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

224914:BME RS12080
gene id: 224914:BME_RS12080
uniprot id: Q8YCZ1
names: Similarity
messages: Belongs to the UPF0309 family.

224914:BME RS00700
gene id: 224914:BME_RS00700
uniprot id: P66651
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

224914:BME RS00165
gene id: 224914:BME_RS00165
uniprot id: Q8YJP5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

224914:BME RS03765
gene id: 224914:BME_RS03765
uniprot id: Q8YHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

224914:BME RS13500
gene id: 224914:BME_RS13500
uniprot id: Q8YC57
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

224914:BME RS10350
gene id: 224914:BME_RS10350
uniprot id: Q9RPX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the virB8 family.
messages: Cell inner membrane

224914:BME RS07370
gene id: 224914:BME_RS07370
uniprot id: Q8YFP7
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

224914:BME RS01580
gene id: 224914:BME_RS01580
uniprot id: Q8YIW3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

224914:BME RS06260
gene id: 224914:BME_RS06260
uniprot id: Q8YGB6
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

224914:BME RS07700
gene id: 224914:BME_RS07700
uniprot id: F8WJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

224914:BME RS10885
gene id: 224914:BME_RS10885
uniprot id: Q8YDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (XylG), two transmembrane proteins (XylH) and a solute-binding protein (XylF).

224914:BME RS13810
gene id: 224914:BME_RS13810
uniprot id: F8WJP0
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

224914:BME RS12310
gene id: 224914:BME_RS12310
uniprot id: Q8YCU5
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS07390
gene id: 224914:BME_RS07390
uniprot id: Q8YFP0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

224914:BME RS04540
gene id: 224914:BME_RS04540
uniprot id: Q8YH92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

224914:BME RS03770
gene id: 224914:BME_RS03770
uniprot id: P64024
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

224914:BME RS13475
gene id: 224914:BME_RS13475
uniprot id: P65611
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

224914:BME RS15070
gene id: 224914:BME_RS15070
uniprot id: Q8YB97
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS10195
gene id: 224914:BME_RS10195
uniprot id: P67193
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

224914:BME RS15325
gene id: 224914:BME_RS15325
uniprot id: Q8YB45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS08780
gene id: 224914:BME_RS08780
uniprot id: P67228
names: Similarity
messages: Belongs to the UPF0102 family.

224914:BME RS10105
gene id: 224914:BME_RS10105
uniprot id: Q8YE37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

224914:BME RS00685
gene id: 224914:BME_RS00685
uniprot id: Q8YJE1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

224914:BME RS12270
gene id: 224914:BME_RS12270
uniprot id: Q8YCV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS13075
gene id: 224914:BME_RS13075
uniprot id: Q8YCE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

224914:BME RS03775
gene id: 224914:BME_RS03775
uniprot id: P66324
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

224914:BME RS03905
gene id: 224914:BME_RS03905
uniprot id: Q8YHL5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

224914:BME RS06945
gene id: 224914:BME_RS06945
uniprot id: Q8YFY3
names: Function
messages: Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).

224914:BME RS09270
gene id: 224914:BME_RS09270
uniprot id: Q8YEK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

224914:BME RS09845
gene id: 224914:BME_RS09845
uniprot id: Q8YE90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

224914:BME RS09110
gene id: 224914:BME_RS09110
uniprot id: Q8YEN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

224914:BME RS11710
gene id: 224914:BME_RS11710
uniprot id: Q8YD69
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

224914:BME RS00830
gene id: 224914:BME_RS00830
uniprot id: Q8YJB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

224914:BME RS07420
gene id: 224914:BME_RS07420
uniprot id: Q8YFN4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

224914:BME RS05310
gene id: 224914:BME_RS05310
uniprot id: Q8YGU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

224914:BME RS04155
gene id: 224914:BME_RS04155
uniprot id: Q8YHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).

224914:BME RS07710
gene id: 224914:BME_RS07710
uniprot id: Q8YFH5
names: Function
names: Similarity
messages: A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.
messages: Belongs to the bacterial AtpI family.

224914:BME RS09840
gene id: 224914:BME_RS09840
uniprot id: Q8YE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

224914:BME RS07630
gene id: 224914:BME_RS07630
uniprot id: Q8YFJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224914:BME RS09785
gene id: 224914:BME_RS09785
uniprot id: Q8YEA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

224914:BME RS03620
gene id: 224914:BME_RS03620
uniprot id: Q8YHR8
names: Similarity
messages: Belongs to the RecJ family.

224914:BME RS07705
gene id: 224914:BME_RS07705
uniprot id: Q8YFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

224914:BME RS04210
gene id: 224914:BME_RS04210
uniprot id: P66988
names: Similarity
messages: Belongs to the TrpC family.

224914:BME RS00815
gene id: 224914:BME_RS00815
uniprot id: Q8YJB4
names: Subcellular Location Annotation
messages: Nucleus

224914:BME RS08070
gene id: 224914:BME_RS08070
uniprot id: Q8YFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

224914:BME RS13280
gene id: 224914:BME_RS13280
uniprot id: Q8YC98
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family.

224914:BME RS14785
gene id: 224914:BME_RS14785
uniprot id: Q8YBF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

224914:BME RS13625
gene id: 224914:BME_RS13625
uniprot id: Q8YC34
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS00020
gene id: 224914:BME_RS00020
uniprot id: Q8YJS9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rho family.
messages: Cell inner membrane
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS00195
gene id: 224914:BME_RS00195
uniprot id: P63615
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

224914:BME RS09225
gene id: 224914:BME_RS09225
uniprot id: Q8YEL6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

224914:BME RS04170
gene id: 224914:BME_RS04170
uniprot id: Q8YHG6
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

224914:BME RS13020
gene id: 224914:BME_RS13020
uniprot id: Q8YCF1
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS11865
gene id: 224914:BME_RS11865
uniprot id: Q8YD33
names: Function
messages: Component of an amino-acid transport system.

224914:BME RS12180
gene id: 224914:BME_RS12180
uniprot id: Q8YCX3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

224914:BME RS02875
gene id: 224914:BME_RS02875
uniprot id: Q8YI67
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS12875
gene id: 224914:BME_RS12875
uniprot id: Q8YCH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS02380
gene id: 224914:BME_RS02380
uniprot id: P63542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS05680
gene id: 224914:BME_RS05680
uniprot id: Q8YGM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

224914:BME RS14855
gene id: 224914:BME_RS14855
uniprot id: Q8YBE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

224914:BME RS00895
gene id: 224914:BME_RS00895
uniprot id: Q8YJ98
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

224914:BME RS04395
gene id: 224914:BME_RS04395
uniprot id: Q8YHC0
names: Function
names: Similarity
messages: Belongs to the ribose 1,5-bisphosphokinase family.
messages: Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).

224914:BME RS04075
gene id: 224914:BME_RS04075
uniprot id: Q9K5F1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

224914:BME RS10280
gene id: 224914:BME_RS10280
uniprot id: P0A3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

224914:BME RS00175
gene id: 224914:BME_RS00175
uniprot id: Q8YJP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

224914:BME RS07655
gene id: 224914:BME_RS07655
uniprot id: Q8YFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the peptidase S49 family.
messages: In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

224914:BME RS05635
gene id: 224914:BME_RS05635
uniprot id: Q8YGN4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

224914:BME RS13185
gene id: 224914:BME_RS13185
uniprot id: Q8YCC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

224914:BME RS06975
gene id: 224914:BME_RS06975
uniprot id: Q8YFX6
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

224914:BME RS10190
gene id: 224914:BME_RS10190
uniprot id: Q8YE19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

224914:BME RS13525
gene id: 224914:BME_RS13525
uniprot id: Q8YC53
names: Function
names: Induction
names: PTM
messages: FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark. However, this protein presents an adduct state that is extremely and unusually stable and does not decay measurably in 2h.
messages: Induced after invasion of host macrophages.
messages: Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host. This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages.

224914:BME RS00320
gene id: 224914:BME_RS00320
uniprot id: Q8YJL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

224914:BME RS04815
gene id: 224914:BME_RS04815
uniprot id: Q8YH37
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

224914:BME RS11180
gene id: 224914:BME_RS11180
uniprot id: Q8YDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS02445
gene id: 224914:BME_RS02445
uniprot id: Q8YIF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

224914:BME RS08510
gene id: 224914:BME_RS08510
uniprot id: Q8YF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

224914:BME RS03720
gene id: 224914:BME_RS03720
uniprot id: Q8YHQ1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

224914:BME RS00635
gene id: 224914:BME_RS00635
uniprot id: P0A3P1
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhizobiaceae omp19 lipoprotein family.
messages: Cell outer membrane
messages: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle.

224914:BME RS01620
gene id: 224914:BME_RS01620
uniprot id: Q8YIV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

224914:BME RS02415
gene id: 224914:BME_RS02415
uniprot id: Q8YIG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

224914:BME RS09235
gene id: 224914:BME_RS09235
uniprot id: P65722
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

224914:BME RS04385
gene id: 224914:BME_RS04385
uniprot id: Q8YHC2
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

224914:BME RS08300
gene id: 224914:BME_RS08300
uniprot id: Q8YF59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

224914:BME RS10640
gene id: 224914:BME_RS10640
uniprot id: Q8YDT3
names: Similarity
messages: Belongs to the ParB family.

224914:BME RS10135
gene id: 224914:BME_RS10135
uniprot id: Q8YE30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

224914:BME RS12170
gene id: 224914:BME_RS12170
uniprot id: Q8YCX5
names: Similarity
messages: Belongs to the UPF0434 family.

224914:BME RS15285
gene id: 224914:BME_RS15285
uniprot id: Q8YB53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

224914:BME RS05785
gene id: 224914:BME_RS05785
uniprot id: Q8YGK4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

224914:BME RS01645
gene id: 224914:BME_RS01645
uniprot id: Q93TG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

224914:BME RS05465
gene id: 224914:BME_RS05465
uniprot id: Q8YGR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

224914:BME RS15350
gene id: 224914:BME_RS15350
uniprot id: Q8YB40
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

224914:BME RS03485
gene id: 224914:BME_RS03485
uniprot id: Q8YHU3
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

224914:BME RS04180
gene id: 224914:BME_RS04180
uniprot id: Q8YHG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

224914:BME RS04750
gene id: 224914:BME_RS04750
uniprot id: Q8YH49
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

224914:BME RS10910
gene id: 224914:BME_RS10910
uniprot id: Q8YDM5
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A fliC mutant is attenuated in a murine model of infection. As the infection progresses, the number of cfu per spleen from mice infected with the mutant is significantly lower than the number from mice infected with the wild-type.
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Despite the presence of a stop codon in position 243 in the fliF gene and in position 127 in the flhA gene, it has been shown that B.melitensis is able to express genes corresponding to the M ring, the hook and the filament of the flagellar apparatus in the early log phase of growth in 2YT broth. Under these conditions, a polar and sheathed flagellar structure is visible by transmission electron microscopy.
messages: Expressed at the onset of the exponential phase (after 4, 8 and 12 hours of culture) but not at later time points.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella (By similarity). The flagellum is required to cause a persistent disease in a murine model of infection.
messages: Secreted

224914:BME RS02575
gene id: 224914:BME_RS02575
uniprot id: Q8YID1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS00825
gene id: 224914:BME_RS00825
uniprot id: P64186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

224914:BME RS03940
gene id: 224914:BME_RS03940
uniprot id: Q8YHK7
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

224914:BME RS13560
gene id: 224914:BME_RS13560
uniprot id: Q8YC47
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS12555
gene id: 224914:BME_RS12555
uniprot id: Q8YCP2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Homotetramer.
messages: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity).

224914:BME RS03970
gene id: 224914:BME_RS03970
uniprot id: P0A3T2
names: Miscellaneous
messages: Brucella abortus is the causative agent for brucellosis in cattle and man.

224914:BME RS14000
gene id: 224914:BME_RS14000
uniprot id: Q8YBV7
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. BioZ family.
messages: Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.

224914:BME RS11510
gene id: 224914:BME_RS11510
uniprot id: Q8YDA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

224914:BME RS11600
gene id: 224914:BME_RS11600
uniprot id: Q8YD90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

224914:BME RS01055
gene id: 224914:BME_RS01055
uniprot id: Q8YJ72
names: Similarity
messages: Belongs to the peptidase S41A family.

224914:BME RS08790
gene id: 224914:BME_RS08790
uniprot id: Q8YEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

224914:BME RS03540
gene id: 224914:BME_RS03540
uniprot id: Q8YHT3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

224914:BME RS06030
gene id: 224914:BME_RS06030
uniprot id: P63646
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

224914:BME RS10360
gene id: 224914:BME_RS10360
uniprot id: Q8YDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Cell membrane

224914:BME RS13495
gene id: 224914:BME_RS13495
uniprot id: P64203
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

224914:BME RS06200
gene id: 224914:BME_RS06200
uniprot id: Q8YGC8
names: Function
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

224914:BME RS04920
gene id: 224914:BME_RS04920
uniprot id: Q8YH17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

224914:BME RS03845
gene id: 224914:BME_RS03845
uniprot id: P66399
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

224914:BME RS08670
gene id: 224914:BME_RS08670
uniprot id: Q8YEY0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

224914:BME RS07380
gene id: 224914:BME_RS07380
uniprot id: Q8YFP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

224914:BME RS01380
gene id: 224914:BME_RS01380
uniprot id: Q8YJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

224914:BME RS05530
gene id: 224914:BME_RS05530
uniprot id: Q8YGQ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS04145
gene id: 224914:BME_RS04145
uniprot id: Q8YHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

224914:BME RS04935
gene id: 224914:BME_RS04935
uniprot id: Q8YH14
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

224914:BME RS06575
gene id: 224914:BME_RS06575
uniprot id: Q7CNU3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alphaproteobacteria porin family.
messages: Cell outer membrane
messages: Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.
messages: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
messages: Monomer.
messages: The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.

224914:BME RS05345
gene id: 224914:BME_RS05345
uniprot id: P64197
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

224914:BME RS11450
gene id: 224914:BME_RS11450
uniprot id: P67384
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

224914:BME RS12260
gene id: 224914:BME_RS12260
uniprot id: Q8YCV5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

224914:BME RS09635
gene id: 224914:BME_RS09635
uniprot id: Q8YED2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

224914:BME RS04160
gene id: 224914:BME_RS04160
uniprot id: P65320
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

224914:BME RS15030
gene id: 224914:BME_RS15030
uniprot id: Q8YBA4
names: Function
messages: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection (By similarity).

224914:BME RS03355
gene id: 224914:BME_RS03355
uniprot id: Q8YHW8
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS07935
gene id: 224914:BME_RS07935
uniprot id: P65654
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

224914:BME RS00580
gene id: 224914:BME_RS00580
uniprot id: Q8YJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

224914:BME RS06520
gene id: 224914:BME_RS06520
uniprot id: Q8YG64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

224914:BME RS10215
gene id: 224914:BME_RS10215
uniprot id: Q8YE15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).

224914:BME RS13005
gene id: 224914:BME_RS13005
uniprot id: Q8YCF4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS07520
gene id: 224914:BME_RS07520
uniprot id: P63607
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

224914:BME RS08075
gene id: 224914:BME_RS08075
uniprot id: P63566
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

224914:BME RS05770
gene id: 224914:BME_RS05770
uniprot id: Q8YGK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

224914:BME RS06415
gene id: 224914:BME_RS06415
uniprot id: Q8YG86
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

224914:BME RS03340
gene id: 224914:BME_RS03340
uniprot id: Q8YHX1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

224914:BME RS09990
gene id: 224914:BME_RS09990
uniprot id: P67003
names: Similarity
messages: Belongs to the TrpF family.

224914:BME RS11965
gene id: 224914:BME_RS11965
uniprot id: Q8YD14
names: Function
messages: Acts on leucine, isoleucine and valine.

224914:BME RS04875
gene id: 224914:BME_RS04875
uniprot id: Q8YH26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Homotrimer.
messages: In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed.

224914:BME RS10880
gene id: 224914:BME_RS10880
uniprot id: Q8YDN1
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS01750
gene id: 224914:BME_RS01750
uniprot id: Q8YIT3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224914:BME RS05105
gene id: 224914:BME_RS05105
uniprot id: Q8YGY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

224914:BME RS03205
gene id: 224914:BME_RS03205
uniprot id: Q8YI01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

224914:BME RS15050
gene id: 224914:BME_RS15050
uniprot id: Q8YBA0
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03100
gene id: 224914:BME_RS03100
uniprot id: Q8YI23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

224914:BME RS05155
gene id: 224914:BME_RS05155
uniprot id: Q8YGX5
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

224914:BME RS15625
gene id: 224914:BME_RS15625
uniprot id: Q8YAY5
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: As bacterial aggregation is one of the initial steps of biofilm formation, the clumping phenotype observed in the vjbR mutant suggests that B.melitensis might be able to form biofilms.
messages: Cells show down-regulated expression of both virB operon and flagellar genes either during culture in bacteriological medium or during intracellular infection. They also show no flgE or fliC production between the end of the latent phase of growth and the beginning of the exponential phase. The vjbR mutant is also strongly attenuated in a mouse model of infection, probably because it is defective in intracellular survival. When cultures reach high density, cells aggregate and form clumps. The mutant is able to produce EPS containing alpha-mannopyranosyl and/or alpha-glucopyranosyl residues as well as a beta-linked glucan that seem to be a component of the extracellular matrix of the aggregates.
messages: Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes, including the virB operon and the flagellar genes fliF and flgE, which are activated in the absence of C12-HSL. Regulates virulence factors as well as several membrane structures. Implicated in the control of outer membrane composition. Plays a role in the expression of genes involved in the EPS synthesis and/or export. Mediates the inhibitory effect of C12-HSL on B.melitensis intracellular replication. Could activate expression of ftcR.

224914:BME RS02060
gene id: 224914:BME_RS02060
uniprot id: Q8YIN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

224914:BME RS06085
gene id: 224914:BME_RS06085
uniprot id: Q8YGE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

224914:BME RS04065
gene id: 224914:BME_RS04065
uniprot id: Q8YHI4
names: Similarity
messages: Belongs to the peptidase S11 family.

224914:BME RS01435
gene id: 224914:BME_RS01435
uniprot id: P52559
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

224914:BME RS07910
gene id: 224914:BME_RS07910
uniprot id: Q8YFD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proline racemase family.
messages: Homotetramer.
messages: In vitro, catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) and that of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with very low efficiency. The physiological substrate may be different (PubMed:24980702). Displays neither proline racemase activity nor t3LHyp dehydratase activity (PubMed:17849014, PubMed:24980702).

224914:BME RS05140
gene id: 224914:BME_RS05140
uniprot id: Q8YGX8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

224914:BME RS04295
gene id: 224914:BME_RS04295
uniprot id: Q8YHE1
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

224914:BME RS09150
gene id: 224914:BME_RS09150
uniprot id: Q8YEN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

224914:BME RS14505
gene id: 224914:BME_RS14505
uniprot id: Q8YBL8
names: Similarity
messages: Belongs to the XFP family.

224914:BME RS13460
gene id: 224914:BME_RS13460
uniprot id: Q8YC65
names: Similarity
messages: Belongs to the DprA/Smf family.

224914:BME RS08705
gene id: 224914:BME_RS08705
uniprot id: Q8YEX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

224914:BME RS09875
gene id: 224914:BME_RS09875
uniprot id: Q8YE82
names: Cofactor
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

224914:BME RS06700
gene id: 224914:BME_RS06700
uniprot id: Q8YG31
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

224914:BME RS01225
gene id: 224914:BME_RS01225
uniprot id: Q8YJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

224914:BME RS05790
gene id: 224914:BME_RS05790
uniprot id: Q8YGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS03810
gene id: 224914:BME_RS03810
uniprot id: Q8YHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

224914:BME RS01705
gene id: 224914:BME_RS01705
uniprot id: P65878
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

224914:BME RS00110
gene id: 224914:BME_RS00110
uniprot id: Q8YJQ8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

224914:BME RS13510
gene id: 224914:BME_RS13510
uniprot id: Q8YC56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

224914:BME RS00160
gene id: 224914:BME_RS00160
uniprot id: Q8YJP6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

224914:BME RS10180
gene id: 224914:BME_RS10180
uniprot id: P63824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

224914:BME RS03855
gene id: 224914:BME_RS03855
uniprot id: Q8YHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

224914:BME RS03500
gene id: 224914:BME_RS03500
uniprot id: Q8YHU0
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

224914:BME RS00250
gene id: 224914:BME_RS00250
uniprot id: P66140
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

224914:BME RS08865
gene id: 224914:BME_RS08865
uniprot id: Q8YEU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

224914:BME RS10840
gene id: 224914:BME_RS10840
uniprot id: Q8YDP0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

224914:BME RS03740
gene id: 224914:BME_RS03740
uniprot id: Q8YHP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

224914:BME RS14270
gene id: 224914:BME_RS14270
uniprot id: F8WJX4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS01385
gene id: 224914:BME_RS01385
uniprot id: Q8YJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

224914:BME RS13275
gene id: 224914:BME_RS13275
uniprot id: Q8YC99
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS14415
gene id: 224914:BME_RS14415
uniprot id: Q8YBN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859).

224914:BME RS14595
gene id: 224914:BME_RS14595
uniprot id: Q8YBK1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

224914:BME RS12130
gene id: 224914:BME_RS12130
uniprot id: P0A2X9
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

224914:BME RS01840
gene id: 224914:BME_RS01840
uniprot id: Q8YIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS07155
gene id: 224914:BME_RS07155
uniprot id: Q8YFU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ureidoglycolate lyase family.
messages: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
messages: Homodimer.

224914:BME RS04465
gene id: 224914:BME_RS04465
uniprot id: Q8YHA5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

224914:BME RS01060
gene id: 224914:BME_RS01060
uniprot id: Q8YJ71
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

224914:BME RS12005
gene id: 224914:BME_RS12005
uniprot id: Q8YD06
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS13050
gene id: 224914:BME_RS13050
uniprot id: Q8YCE8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS04125
gene id: 224914:BME_RS04125
uniprot id: P94340
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

224914:BME RS00595
gene id: 224914:BME_RS00595
uniprot id: Q8YJF7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

224914:BME RS09490
gene id: 224914:BME_RS09490
uniprot id: Q8YEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

224914:BME RS06400
gene id: 224914:BME_RS06400
uniprot id: Q8YG89
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

224914:BME RS04220
gene id: 224914:BME_RS04220
uniprot id: Q8YHF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

224914:BME RS00860
gene id: 224914:BME_RS00860
uniprot id: Q8YJA5
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03960
gene id: 224914:BME_RS03960
uniprot id: Q8YHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS13115
gene id: 224914:BME_RS13115
uniprot id: Q8YCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

224914:BME RS00585
gene id: 224914:BME_RS00585
uniprot id: Q8YJF9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

224914:BME RS12305
gene id: 224914:BME_RS12305
uniprot id: Q8YCU6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS12160
gene id: 224914:BME_RS12160
uniprot id: Q8YCX7
names: Similarity
messages: Belongs to the thioredoxin family.

224914:BME RS07335
gene id: 224914:BME_RS07335
uniprot id: Q8YFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

224914:BME RS12385
gene id: 224914:BME_RS12385
uniprot id: Q8YCS8
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

224914:BME RS00065
gene id: 224914:BME_RS00065
uniprot id: Q8YJR9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS05175
gene id: 224914:BME_RS05175
uniprot id: Q8YGX0
names: Similarity
messages: Belongs to the DEAD box helicase family.

224914:BME RS11385
gene id: 224914:BME_RS11385
uniprot id: Q8YDD2
names: Similarity
messages: Belongs to the universal stress protein A family.

224914:BME RS13420
gene id: 224914:BME_RS13420
uniprot id: Q8YC72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS03040
gene id: 224914:BME_RS03040
uniprot id: Q8YI35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

224914:BME RS11485
gene id: 224914:BME_RS11485
uniprot id: P64132
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

224914:BME RS10370
gene id: 224914:BME_RS10370
uniprot id: Q8YDY8
names: Subcellular Location Annotation
messages: Cell outer membrane

224914:BME RS15615
gene id: 224914:BME_RS15615
uniprot id: Q8YAY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

224914:BME RS00510
gene id: 224914:BME_RS00510
uniprot id: Q8YJH3
names: Similarity
messages: Belongs to the arginase family.

224914:BME RS12925
gene id: 224914:BME_RS12925
uniprot id: Q8YCH0
names: Similarity
messages: Belongs to the GcvT family.

224914:BME RS06250
gene id: 224914:BME_RS06250
uniprot id: Q8YGB8
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

224914:BME RS04225
gene id: 224914:BME_RS04225
uniprot id: Q8YHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

224914:BME RS10400
gene id: 224914:BME_RS10400
uniprot id: Q8YDY2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

224914:BME RS14735
gene id: 224914:BME_RS14735
uniprot id: Q8YBH0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

224914:BME RS02205
gene id: 224914:BME_RS02205
uniprot id: Q8YIK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS15660
gene id: 224914:BME_RS15660
uniprot id: Q8YAX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

224914:BME RS08730
gene id: 224914:BME_RS08730
uniprot id: Q8YEW8
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

224914:BME RS15280
gene id: 224914:BME_RS15280
uniprot id: P0A342
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: By heat shock.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

224914:BME RS08915
gene id: 224914:BME_RS08915
uniprot id: Q8YES8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

224914:BME RS14435
gene id: 224914:BME_RS14435
uniprot id: Q8YBN1
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS14115
gene id: 224914:BME_RS14115
uniprot id: Q8YBT5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

224914:BME RS03215
gene id: 224914:BME_RS03215
uniprot id: Q8YHZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

224914:BME RS11840
gene id: 224914:BME_RS11840
uniprot id: Q8YD38
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

224914:BME RS10615
gene id: 224914:BME_RS10615
uniprot id: Q8YDT8
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS06535
gene id: 224914:BME_RS06535
uniprot id: P66858
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

224914:BME RS09555
gene id: 224914:BME_RS09555
uniprot id: Q8YEE8
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS03865
gene id: 224914:BME_RS03865
uniprot id: P66570
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

224914:BME RS01185
gene id: 224914:BME_RS01185
uniprot id: Q8YJ45
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

224914:BME RS00770
gene id: 224914:BME_RS00770
uniprot id: Q8YJC4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

224914:BME RS04400
gene id: 224914:BME_RS04400
uniprot id: Q8YHB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

224914:BME RS09010
gene id: 224914:BME_RS09010
uniprot id: Q8YEQ9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

224914:BME RS10585
gene id: 224914:BME_RS10585
uniprot id: Q8YDU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. EntD family.
messages: EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.
messages: Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.

224914:BME RS02950
gene id: 224914:BME_RS02950
uniprot id: Q8YI52
names: Similarity
messages: Belongs to the SCO1/2 family.

224914:BME RS05560
gene id: 224914:BME_RS05560
uniprot id: Q8YGP9
names: Similarity
messages: Belongs to the aldose epimerase family.

224914:BME RS14955
gene id: 224914:BME_RS14955
uniprot id: Q8YBC0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

224914:BME RS05470
gene id: 224914:BME_RS05470
uniprot id: P63933
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

224914:BME RS04860
gene id: 224914:BME_RS04860
uniprot id: Q8YH29
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

224914:BME RS07610
gene id: 224914:BME_RS07610
uniprot id: Q8YFJ4
names: Similarity
messages: Belongs to the RelE toxin family.

224914:BME RS13950
gene id: 224914:BME_RS13950
uniprot id: Q8YBW7
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS04000
gene id: 224914:BME_RS04000
uniprot id: Q8YHJ6
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

224914:BME RS04240
gene id: 224914:BME_RS04240
uniprot id: Q8YHF2
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

224914:BME RS10275
gene id: 224914:BME_RS10275
uniprot id: P0A3N8
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhizobiaceae omp10 lipoprotein family.
messages: Cell outer membrane
messages: Elicits an immune response in B.melitensis-infected sheep but not in B.abortus-infected cattle.

224914:BME RS03030
gene id: 224914:BME_RS03030
uniprot id: P67042
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS03900
gene id: 224914:BME_RS03900
uniprot id: Q8YHL6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

224914:BME RS01350
gene id: 224914:BME_RS01350
uniprot id: Q8YJ09
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

224914:BME RS12480
gene id: 224914:BME_RS12480
uniprot id: Q8YCR0
names: Similarity
messages: Belongs to the UPF0166 family.

224914:BME RS09165
gene id: 224914:BME_RS09165
uniprot id: Q8YEM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

224914:BME RS13095
gene id: 224914:BME_RS13095
uniprot id: Q8YCE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS06330
gene id: 224914:BME_RS06330
uniprot id: Q8YGA3
names: Similarity
messages: Belongs to the DinB family.

224914:BME RS05515
gene id: 224914:BME_RS05515
uniprot id: Q8YGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

224914:BME RS13225
gene id: 224914:BME_RS13225
uniprot id: Q8YCB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

224914:BME RS00450
gene id: 224914:BME_RS00450
uniprot id: Q8YJI7
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

224914:BME RS14740
gene id: 224914:BME_RS14740
uniprot id: P65546
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

224914:BME RS05745
gene id: 224914:BME_RS05745
uniprot id: Q8YGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

224914:BME RS10695
gene id: 224914:BME_RS10695
uniprot id: Q8YDS0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Heme transporter.
messages: Induced in absence of iron.

224914:BME RS04290
gene id: 224914:BME_RS04290
uniprot id: P65281
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

224914:BME RS09090
gene id: 224914:BME_RS09090
uniprot id: Q8YEP2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

224914:BME RS10500
gene id: 224914:BME_RS10500
uniprot id: Q8YDV9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS06645
gene id: 224914:BME_RS06645
uniprot id: Q8YG42
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

224914:BME RS09935
gene id: 224914:BME_RS09935
uniprot id: P66101
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

224914:BME RS15180
gene id: 224914:BME_RS15180
uniprot id: P65489
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

224914:BME RS01775
gene id: 224914:BME_RS01775
uniprot id: F8WJP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

224914:BME RS04930
gene id: 224914:BME_RS04930
uniprot id: Q8YH15
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

224914:BME RS10625
gene id: 224914:BME_RS10625
uniprot id: Q8YDT6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

224914:BME RS15190
gene id: 224914:BME_RS15190
uniprot id: P65325
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

224914:BME RS03780
gene id: 224914:BME_RS03780
uniprot id: Q8YHP0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

224914:BME RS07405
gene id: 224914:BME_RS07405
uniprot id: Q8YFN7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

224914:BME RS00740
gene id: 224914:BME_RS00740
uniprot id: P66078
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

224914:BME RS11490
gene id: 224914:BME_RS11490
uniprot id: Q8YDB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

224914:BME RS15295
gene id: 224914:BME_RS15295
uniprot id: Q8YB50
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

224914:BME RS10020
gene id: 224914:BME_RS10020
uniprot id: Q8YE56
names: Similarity
messages: Belongs to the thioredoxin family.

224914:BME RS06705
gene id: 224914:BME_RS06705
uniprot id: Q8YG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

224914:BME RS07375
gene id: 224914:BME_RS07375
uniprot id: P63437
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

224914:BME RS08180
gene id: 224914:BME_RS08180
uniprot id: Q8YF79
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

224914:BME RS00060
gene id: 224914:BME_RS00060
uniprot id: Q8YJS0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS07295
gene id: 224914:BME_RS07295
uniprot id: Q8YFR2
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

224914:BME RS11335
gene id: 224914:BME_RS11335
uniprot id: Q8YDE5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

224914:BME RS05750
gene id: 224914:BME_RS05750
uniprot id: Q8YGL1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

224914:BME RS05085
gene id: 224914:BME_RS05085
uniprot id: Q8YGY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

224914:BME RS14570
gene id: 224914:BME_RS14570
uniprot id: Q8YBK6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS14860
gene id: 224914:BME_RS14860
uniprot id: Q8YBD9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS06045
gene id: 224914:BME_RS06045
uniprot id: P67012
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS14945
gene id: 224914:BME_RS14945
uniprot id: Q8YBC2
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

224914:BME RS06300
gene id: 224914:BME_RS06300
uniprot id: Q8YGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

224914:BME RS03545
gene id: 224914:BME_RS03545
uniprot id: Q8YHT2
names: Similarity
messages: Belongs to the CobH/CbiC family.

224914:BME RS10315
gene id: 224914:BME_RS10315
uniprot id: Q8YDZ5
names: Similarity
messages: Belongs to the virb1 family.

224914:BME RS03195
gene id: 224914:BME_RS03195
uniprot id: Q8YI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

224914:BME RS03565
gene id: 224914:BME_RS03565
uniprot id: P65955
names: Similarity
messages: Belongs to the UPF0758 family.

224914:BME RS12175
gene id: 224914:BME_RS12175
uniprot id: Q8YCX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS00755
gene id: 224914:BME_RS00755
uniprot id: Q8YJC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

224914:BME RS07575
gene id: 224914:BME_RS07575
uniprot id: Q8YFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

224914:BME RS01890
gene id: 224914:BME_RS01890
uniprot id: Q8YIQ9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS02870
gene id: 224914:BME_RS02870
uniprot id: Q8YI68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

224914:BME RS05430
gene id: 224914:BME_RS05430
uniprot id: Q8YGS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

224914:BME RS07110
gene id: 224914:BME_RS07110
uniprot id: F8WJP6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Fmt family.
messages: Deletion mutant is completely O-antigen-negative.
messages: Homodimer.
messages: Involved in the lipopolysaccharide (LPS) O-antigen biosynthesis (PubMed:11081580). Catalyzes the transfer of a formyl group to GDP-perosamine, leading to the formation of GDP-N-formylperosamine (PubMed:11081580, PubMed:28636341). In vitro, can also function on GDP-3-deoxyperosamine, thereby providing an enzymatic method for producing a novel trideoxysugar not found in nature (PubMed:28636341).

224914:BME RS00040
gene id: 224914:BME_RS00040
uniprot id: Q8YJS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

224914:BME RS08925
gene id: 224914:BME_RS08925
uniprot id: Q8YES6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

224914:BME RS03220
gene id: 224914:BME_RS03220
uniprot id: Q8YHZ8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

224914:BME RS13555
gene id: 224914:BME_RS13555
uniprot id: Q8YC48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

224914:BME RS12560
gene id: 224914:BME_RS12560
uniprot id: Q8YCP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS10925
gene id: 224914:BME_RS10925
uniprot id: Q8YDM1
names: Similarity
messages: Belongs to the MotB family.

224914:BME RS07950
gene id: 224914:BME_RS07950
uniprot id: Q8YFC6
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03730
gene id: 224914:BME_RS03730
uniprot id: Q8YHP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).

224914:BME RS15650
gene id: 224914:BME_RS15650
uniprot id: Q8YAY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS11135
gene id: 224914:BME_RS11135
uniprot id: Q8YDI4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS10815
gene id: 224914:BME_RS10815
uniprot id: Q8YDP5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS04825
gene id: 224914:BME_RS04825
uniprot id: Q8YH36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

224914:BME RS04455
gene id: 224914:BME_RS04455
uniprot id: Q8YHA8
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

224914:BME RS13990
gene id: 224914:BME_RS13990
uniprot id: Q8YBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS05990
gene id: 224914:BME_RS05990
uniprot id: P67311
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

224914:BME RS09435
gene id: 224914:BME_RS09435
uniprot id: Q8YEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

224914:BME RS09175
gene id: 224914:BME_RS09175
uniprot id: Q8YEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).

224914:BME RS09710
gene id: 224914:BME_RS09710
uniprot id: Q8YEB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

224914:BME RS01105
gene id: 224914:BME_RS01105
uniprot id: Q8YJ61
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cell inner membrane
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

224914:BME RS05870
gene id: 224914:BME_RS05870
uniprot id: Q8YGJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

224914:BME RS05510
gene id: 224914:BME_RS05510
uniprot id: Q8YGQ9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

224914:BME RS00915
gene id: 224914:BME_RS00915
uniprot id: Q8YJ94
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

224914:BME RS07020
gene id: 224914:BME_RS07020
uniprot id: Q8YFW7
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

224914:BME RS09180
gene id: 224914:BME_RS09180
uniprot id: Q8YEM3
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

224914:BME RS07300
gene id: 224914:BME_RS07300
uniprot id: Q8YFR1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

224914:BME RS00005
gene id: 224914:BME_RS00005
uniprot id: Q8YJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS12050
gene id: 224914:BME_RS12050
uniprot id: Q8YCZ7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224914:BME RS11260
gene id: 224914:BME_RS11260
uniprot id: Q7CNS6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

224914:BME RS10010
gene id: 224914:BME_RS10010
uniprot id: Q8YE58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

224914:BME RS03830
gene id: 224914:BME_RS03830
uniprot id: Q8YHN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

224914:BME RS00905
gene id: 224914:BME_RS00905
uniprot id: Q8YJ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

224914:BME RS07415
gene id: 224914:BME_RS07415
uniprot id: Q8YFN5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

224914:BME RS15640
gene id: 224914:BME_RS15640
uniprot id: Q8YAY2
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS11280
gene id: 224914:BME_RS11280
uniprot id: Q7CNS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

224914:BME RS02400
gene id: 224914:BME_RS02400
uniprot id: P65863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

224914:BME RS10680
gene id: 224914:BME_RS10680
uniprot id: Q8YDS3
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS01500
gene id: 224914:BME_RS01500
uniprot id: Q8YIY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

224914:BME RS06620
gene id: 224914:BME_RS06620
uniprot id: Q8YG46
names: Similarity
messages: Belongs to the GST superfamily.

224914:BME RS13820
gene id: 224914:BME_RS13820
uniprot id: Q8YBZ5
names: Similarity
messages: Belongs to the peptidase S58 family.

224914:BME RS07305
gene id: 224914:BME_RS07305
uniprot id: Q8YFR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

224914:BME RS06315
gene id: 224914:BME_RS06315
uniprot id: P65396
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).

224914:BME RS09160
gene id: 224914:BME_RS09160
uniprot id: Q8YEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

224914:BME RS14690
gene id: 224914:BME_RS14690
uniprot id: Q8YBH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

224914:BME RS03975
gene id: 224914:BME_RS03975
uniprot id: Q8YHK1
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

224914:BME RS07865
gene id: 224914:BME_RS07865
uniprot id: Q8YFE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide deacetylase family.
messages: Cytoplasm
messages: Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.

224914:BME RS00630
gene id: 224914:BME_RS00630
uniprot id: Q8YJF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS03945
gene id: 224914:BME_RS03945
uniprot id: Q8YHK6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

224914:BME RS06500
gene id: 224914:BME_RS06500
uniprot id: Q8YG68
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

224914:BME RS11525
gene id: 224914:BME_RS11525
uniprot id: Q8YDA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

224914:BME RS03575
gene id: 224914:BME_RS03575
uniprot id: Q8YHS6
names: Similarity
messages: Belongs to the SfsA family.

224914:BME RS04755
gene id: 224914:BME_RS04755
uniprot id: Q8YH48
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

224914:BME RS04380
gene id: 224914:BME_RS04380
uniprot id: Q8YHC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

224914:BME RS04135
gene id: 224914:BME_RS04135
uniprot id: Q8YHH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Cell inner membrane

224914:BME RS12745
gene id: 224914:BME_RS12745
uniprot id: Q8YCK5
names: Function
names: Similarity
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

224914:BME RS07900
gene id: 224914:BME_RS07900
uniprot id: Q8YFD8
names: Similarity
messages: Belongs to the IalB family.

224914:BME RS09200
gene id: 224914:BME_RS09200
uniprot id: Q8YEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

224914:BME RS07255
gene id: 224914:BME_RS07255
uniprot id: Q8YFS0
names: Similarity
messages: Belongs to the threonine synthase family.

224914:BME RS05665
gene id: 224914:BME_RS05665
uniprot id: Q8YGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

224914:BME RS00380
gene id: 224914:BME_RS00380
uniprot id: Q8YJK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

224914:BME RS01685
gene id: 224914:BME_RS01685
uniprot id: Q8YIU6
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS04640
gene id: 224914:BME_RS04640
uniprot id: Q8YH72
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

224914:BME RS05425
gene id: 224914:BME_RS05425
uniprot id: Q8YGS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

224914:BME RS07755
gene id: 224914:BME_RS07755
uniprot id: Q8YFG5
names: Similarity
messages: Belongs to the ArsC family.

224914:BME RS04350
gene id: 224914:BME_RS04350
uniprot id: P0A3G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

224914:BME RS02930
gene id: 224914:BME_RS02930
uniprot id: Q8YI56
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

224914:BME RS08595
gene id: 224914:BME_RS08595
uniprot id: Q8YEZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

224914:BME RS00555
gene id: 224914:BME_RS00555
uniprot id: Q8YJG5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

224914:BME RS05415
gene id: 224914:BME_RS05415
uniprot id: Q8YGS8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

224914:BME RS07990
gene id: 224914:BME_RS07990
uniprot id: Q8YFB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

224914:BME RS10290
gene id: 224914:BME_RS10290
uniprot id: Q8YE00
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03160
gene id: 224914:BME_RS03160
uniprot id: Q8YI11
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

224914:BME RS08940
gene id: 224914:BME_RS08940
uniprot id: Q8YES3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

224914:BME RS01855
gene id: 224914:BME_RS01855
uniprot id: Q8YIR6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

224914:BME RS01285
gene id: 224914:BME_RS01285
uniprot id: Q8YJ23
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS00660
gene id: 224914:BME_RS00660
uniprot id: Q8YJE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

224914:BME RS01960
gene id: 224914:BME_RS01960
uniprot id: Q8YIQ1
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS11590
gene id: 224914:BME_RS11590
uniprot id: Q8YD92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

224914:BME RS09730
gene id: 224914:BME_RS09730
uniprot id: Q8YEB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

224914:BME RS06325
gene id: 224914:BME_RS06325
uniprot id: Q8YGA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

224914:BME RS02250
gene id: 224914:BME_RS02250
uniprot id: Q8YIJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
messages: Membrane

224914:BME RS14475
gene id: 224914:BME_RS14475
uniprot id: Q8YBM4
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS09035
gene id: 224914:BME_RS09035
uniprot id: Q8YEQ4
names: Similarity
messages: Belongs to the DEAD box helicase family.

224914:BME RS09100
gene id: 224914:BME_RS09100
uniprot id: P63353
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

224914:BME RS10170
gene id: 224914:BME_RS10170
uniprot id: Q8YE23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

224914:BME RS05935
gene id: 224914:BME_RS05935
uniprot id: P64390
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

224914:BME RS05625
gene id: 224914:BME_RS05625
uniprot id: Q8YGN6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

224914:BME RS06460
gene id: 224914:BME_RS06460
uniprot id: Q8YG76
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

224914:BME RS06305
gene id: 224914:BME_RS06305
uniprot id: Q8YGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

224914:BME RS06530
gene id: 224914:BME_RS06530
uniprot id: Q8YG62
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

224914:BME RS06980
gene id: 224914:BME_RS06980
uniprot id: Q8YFX5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

224914:BME RS12485
gene id: 224914:BME_RS12485
uniprot id: Q8YCQ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

224914:BME RS05880
gene id: 224914:BME_RS05880
uniprot id: Q8YGI9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

224914:BME RS12650
gene id: 224914:BME_RS12650
uniprot id: Q8YCM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS09495
gene id: 224914:BME_RS09495
uniprot id: Q8YEG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

224914:BME RS02925
gene id: 224914:BME_RS02925
uniprot id: Q8YI57
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

224914:BME RS09605
gene id: 224914:BME_RS09605
uniprot id: Q8YED7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

224914:BME RS12630
gene id: 224914:BME_RS12630
uniprot id: Q8YCM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

224914:BME RS11325
gene id: 224914:BME_RS11325
uniprot id: Q8YDE7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

224914:BME RS06465
gene id: 224914:BME_RS06465
uniprot id: Q8YG75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

224914:BME RS08195
gene id: 224914:BME_RS08195
uniprot id: Q8YF76
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224914:BME RS00650
gene id: 224914:BME_RS00650
uniprot id: P66867
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

224914:BME RS10955
gene id: 224914:BME_RS10955
uniprot id: Q8YDL5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

224914:BME RS13150
gene id: 224914:BME_RS13150
uniprot id: Q8YCC8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS10325
gene id: 224914:BME_RS10325
uniprot id: Q9RPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the virB3 family.
messages: Cell membrane

224914:BME RS09770
gene id: 224914:BME_RS09770
uniprot id: Q8YEA5
names: Similarity
messages: Belongs to the UPF0053 family. Hemolysin C subfamily.

224914:BME RS06870
gene id: 224914:BME_RS06870
uniprot id: Q8YFZ7
names: Similarity
messages: Belongs to the peptidase S9A family.

224914:BME RS04880
gene id: 224914:BME_RS04880
uniprot id: Q8YH25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: Oligomer of 12 subunits arranged in the form of two hexameric ring.

224914:BME RS01115
gene id: 224914:BME_RS01115
uniprot id: P66433
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

224914:BME RS03415
gene id: 224914:BME_RS03415
uniprot id: Q8YHV7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

224914:BME RS01830
gene id: 224914:BME_RS01830
uniprot id: Q8YIS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

224914:BME RS00835
gene id: 224914:BME_RS00835
uniprot id: Q8YJB0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

224914:BME RS13790
gene id: 224914:BME_RS13790
uniprot id: Q8YC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS01315
gene id: 224914:BME_RS01315
uniprot id: Q8YJ16
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

224914:BME RS12495
gene id: 224914:BME_RS12495
uniprot id: Q8YCQ6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224914:BME RS09460
gene id: 224914:BME_RS09460
uniprot id: P67260
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

224914:BME RS02940
gene id: 224914:BME_RS02940
uniprot id: Q8YI54
names: Similarity
messages: Belongs to the peptidase M24B family.

224914:BME RS03230
gene id: 224914:BME_RS03230
uniprot id: Q8YHZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

224914:BME RS00170
gene id: 224914:BME_RS00170
uniprot id: Q8YJP4
names: Similarity
messages: Belongs to the YkuD family.

224914:BME RS01665
gene id: 224914:BME_RS01665
uniprot id: Q8YIV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

224914:BME RS07665
gene id: 224914:BME_RS07665
uniprot id: Q8YFI3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

224914:BME RS06565
gene id: 224914:BME_RS06565
uniprot id: Q8YG56
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alphaproteobacteria porin family.
messages: Cell outer membrane
messages: Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.
messages: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
messages: Homotrimer.
messages: The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.

224914:BME RS01215
gene id: 224914:BME_RS01215
uniprot id: Q8YJ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

224914:BME RS03745
gene id: 224914:BME_RS03745
uniprot id: Q8YHP7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

224914:BME RS04620
gene id: 224914:BME_RS04620
uniprot id: Q8YH76
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

224914:BME RS08795
gene id: 224914:BME_RS08795
uniprot id: P64305
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

224914:BME RS04015
gene id: 224914:BME_RS04015
uniprot id: Q8YHJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

224914:BME RS03365
gene id: 224914:BME_RS03365
uniprot id: Q8YHW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

224914:BME RS04735
gene id: 224914:BME_RS04735
uniprot id: Q8YH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane

224914:BME RS02315
gene id: 224914:BME_RS02315
uniprot id: Q8YII1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

224914:BME RS11420
gene id: 224914:BME_RS11420
uniprot id: Q8YDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

224914:BME RS10335
gene id: 224914:BME_RS10335
uniprot id: Q8YDZ3
names: Similarity
messages: Belongs to the virb5 family.

224914:BME RS11770
gene id: 224914:BME_RS11770
uniprot id: Q8YD54
names: Similarity
messages: Belongs to the AlaDH/PNT family.

224914:BME RS10110
gene id: 224914:BME_RS10110
uniprot id: Q8YE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

224914:BME RS05475
gene id: 224914:BME_RS05475
uniprot id: Q8YGR7
names: Similarity
messages: Belongs to the HesB/IscA family.

224914:BME RS13260
gene id: 224914:BME_RS13260
uniprot id: Q8YCA3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS09475
gene id: 224914:BME_RS09475
uniprot id: Q8YEG5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS03890
gene id: 224914:BME_RS03890
uniprot id: P66381
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

224914:BME RS02715
gene id: 224914:BME_RS02715
uniprot id: Q8YIA2
names: Similarity
messages: Belongs to the peptidase C59 family.

224914:BME RS08245
gene id: 224914:BME_RS08245
uniprot id: Q8YF70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

224914:BME RS04530
gene id: 224914:BME_RS04530
uniprot id: Q8YH94
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

224914:BME RS10510
gene id: 224914:BME_RS10510
uniprot id: Q8YDV7
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS04945
gene id: 224914:BME_RS04945
uniprot id: Q8YH12
names: Similarity
messages: Belongs to the ArsC family.

224914:BME RS10950
gene id: 224914:BME_RS10950
uniprot id: Q8YDL6
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A flgE mutant is attenuated in a murine model of infection. Four weeks after infection, the number of cfu per spleen from mice infected with the mutant is significantly lower than the number from mice infected with the wild-type.
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Despite the presence of a stop codon in position 243 in the fliF gene and in position 127 in the flhA gene, it has been shown that B.melitensis is able to express genes corresponding to the M ring, the hook and the filament of the flagellar apparatus in the early log phase of growth in 2YT broth. Under these conditions, a polar and sheathed flagellar structure is visible by transmission electron microscopy.
messages: Expressed at the onset of the exponential phase (after 4, 8 and 12 hours of culture) but not at later time points.
messages: The flagellum is required to cause a persistent disease in a murine model of infection.

224914:BME RS15590
gene id: 224914:BME_RS15590
uniprot id: Q8YAZ1
names: Function
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.

224914:BME RS08150
gene id: 224914:BME_RS08150
uniprot id: Q8YF86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

224914:BME RS10675
gene id: 224914:BME_RS10675
uniprot id: Q8YDS4
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS10700
gene id: 224914:BME_RS10700
uniprot id: Q8YDR9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

224914:BME RS14695
gene id: 224914:BME_RS14695
uniprot id: Q8YBH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

224914:BME RS05915
gene id: 224914:BME_RS05915
uniprot id: Q8YGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

224914:BME RS12765
gene id: 224914:BME_RS12765
uniprot id: Q8YCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

224914:BME RS11185
gene id: 224914:BME_RS11185
uniprot id: Q7CNS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

224914:BME RS02905
gene id: 224914:BME_RS02905
uniprot id: Q8YI61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

224914:BME RS13125
gene id: 224914:BME_RS13125
uniprot id: Q8YCD3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS07555
gene id: 224914:BME_RS07555
uniprot id: Q8YFK8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

224914:BME RS05375
gene id: 224914:BME_RS05375
uniprot id: P64232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

224914:BME RS15480
gene id: 224914:BME_RS15480
uniprot id: P67706
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.

224914:BME RS13935
gene id: 224914:BME_RS13935
uniprot id: Q8YBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

224914:BME RS01310
gene id: 224914:BME_RS01310
uniprot id: Q8YJ17
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

224914:BME RS04885
gene id: 224914:BME_RS04885
uniprot id: Q8YH24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

224914:BME RS15035
gene id: 224914:BME_RS15035
uniprot id: Q8YBA3
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

224914:BME RS00410
gene id: 224914:BME_RS00410
uniprot id: Q8YJJ5
names: Similarity
messages: Belongs to the UPF0178 family.

224914:BME RS14375
gene id: 224914:BME_RS14375
uniprot id: Q8YBP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NanM family.
messages: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
messages: Homodimer.
messages: Periplasm

224914:BME RS03850
gene id: 224914:BME_RS03850
uniprot id: Q8YHM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

224914:BME RS03610
gene id: 224914:BME_RS03610
uniprot id: Q8YHS0
names: Similarity
messages: Belongs to the FBPase class 2 family.

224914:BME RS07620
gene id: 224914:BME_RS07620
uniprot id: Q8YFJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

224914:BME RS04580
gene id: 224914:BME_RS04580
uniprot id: Q8YH83
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

224914:BME RS03420
gene id: 224914:BME_RS03420
uniprot id: Q8YHV6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

224914:BME RS07290
gene id: 224914:BME_RS07290
uniprot id: P66673
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

224914:BME RS05290
gene id: 224914:BME_RS05290
uniprot id: Q8YGV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
messages: Homotetramer formed by a dimer of dimers.

224914:BME RS05715
gene id: 224914:BME_RS05715
uniprot id: Q8YGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Cytoplasm
messages: Homodimer.

224914:BME RS08305
gene id: 224914:BME_RS08305
uniprot id: P67567
names: Similarity
messages: Belongs to the UPF0262 family.

224914:BME RS12100
gene id: 224914:BME_RS12100
uniprot id: Q8YCY7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS13995
gene id: 224914:BME_RS13995
uniprot id: Q8YBV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS14615
gene id: 224914:BME_RS14615
uniprot id: Q8YBJ6
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03435
gene id: 224914:BME_RS03435
uniprot id: Q8YHV3
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

224914:BME RS12340
gene id: 224914:BME_RS12340
uniprot id: Q8YCT8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

224914:BME RS05600
gene id: 224914:BME_RS05600
uniprot id: Q8YGP1
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

224914:BME RS14340
gene id: 224914:BME_RS14340
uniprot id: F8WJP4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS00910
gene id: 224914:BME_RS00910
uniprot id: Q8YJ95
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

224914:BME RS00310
gene id: 224914:BME_RS00310
uniprot id: Q9L772
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell inner membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.

224914:BME RS12655
gene id: 224914:BME_RS12655
uniprot id: Q8YCM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

224914:BME RS09720
gene id: 224914:BME_RS09720
uniprot id: Q8YEB5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

224914:BME RS08215
gene id: 224914:BME_RS08215
uniprot id: Q8YF73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

224914:BME RS01020
gene id: 224914:BME_RS01020
uniprot id: P65790
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

224914:BME RS11425
gene id: 224914:BME_RS11425
uniprot id: P0A3Q2
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

224914:BME RS14320
gene id: 224914:BME_RS14320
uniprot id: P0A3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Omp25/RopB family.
messages: Cell outer membrane
messages: Major outer membrane protein associated with peptidoglycans. May function as a porin.
messages: Oligomeric.

224914:BME RS01455
gene id: 224914:BME_RS01455
uniprot id: Q8YIY9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS08020
gene id: 224914:BME_RS08020
uniprot id: Q8YFB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

224914:BME RS11250
gene id: 224914:BME_RS11250
uniprot id: Q8YDG0
names: Function
names: Subunit
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

224914:BME RS15105
gene id: 224914:BME_RS15105
uniprot id: Q8YB90
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

224914:BME RS04275
gene id: 224914:BME_RS04275
uniprot id: Q8YHE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

224914:BME RS14905
gene id: 224914:BME_RS14905
uniprot id: Q8YBD0
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS14170
gene id: 224914:BME_RS14170
uniprot id: Q8YBS3
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

224914:BME RS10715
gene id: 224914:BME_RS10715
uniprot id: Q8YDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm
messages: Probably part of an ABC transporter complex.
messages: The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109).

224914:BME RS12345
gene id: 224914:BME_RS12345
uniprot id: Q8YCT7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS08785
gene id: 224914:BME_RS08785
uniprot id: Q8YEV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

224914:BME RS14725
gene id: 224914:BME_RS14725
uniprot id: Q8YBH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

224914:BME RS01120
gene id: 224914:BME_RS01120
uniprot id: Q8YJ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

224914:BME RS03885
gene id: 224914:BME_RS03885
uniprot id: Q8YHL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

224914:BME RS04435
gene id: 224914:BME_RS04435
uniprot id: Q8YHB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

224914:BME RS01545
gene id: 224914:BME_RS01545
uniprot id: Q8YIX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

224914:BME RS04365
gene id: 224914:BME_RS04365
uniprot id: Q8YHC7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

224914:BME RS11255
gene id: 224914:BME_RS11255
uniprot id: Q7CNS7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

224914:BME RS07920
gene id: 224914:BME_RS07920
uniprot id: Q8YFD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS08560
gene id: 224914:BME_RS08560
uniprot id: Q8YF04
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

224914:BME RS09300
gene id: 224914:BME_RS09300
uniprot id: Q8YEK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

224914:BME RS10805
gene id: 224914:BME_RS10805
uniprot id: Q8YDP7
names: Similarity
messages: Belongs to the UPF0261 family.

224914:BME RS06290
gene id: 224914:BME_RS06290
uniprot id: Q45321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Omp25/RopB family.
messages: Cell outer membrane

224914:BME RS07480
gene id: 224914:BME_RS07480
uniprot id: Q8YFM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

224914:BME RS11480
gene id: 224914:BME_RS11480
uniprot id: P63913
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

224914:BME RS10130
gene id: 224914:BME_RS10130
uniprot id: Q8YE31
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

224914:BME RS10940
gene id: 224914:BME_RS10940
uniprot id: Q8YDL8
names: Similarity
messages: Belongs to the virb1 family.

224914:BME RS00840
gene id: 224914:BME_RS00840
uniprot id: Q8YJA9
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

224914:BME RS15265
gene id: 224914:BME_RS15265
uniprot id: Q8YB57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

224914:BME RS04690
gene id: 224914:BME_RS04690
uniprot id: Q8YH61
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

224914:BME RS03805
gene id: 224914:BME_RS03805
uniprot id: Q8YHN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

224914:BME RS13080
gene id: 224914:BME_RS13080
uniprot id: P61712
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
messages: Homodecamer, arranged as a dimer of pentamers.
messages: The two ribH genes may be differentially expressed during the Brucella infection cycle. Brucella would use RibH1 for flavin biosynthesis during the extracellular phase and RibH2 during intracellular growth (By similarity).

224914:BME RS01220
gene id: 224914:BME_RS01220
uniprot id: Q8YJ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

224914:BME RS05805
gene id: 224914:BME_RS05805
uniprot id: Q8YGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS00445
gene id: 224914:BME_RS00445
uniprot id: Q8YJI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

224914:BME RS09255
gene id: 224914:BME_RS09255
uniprot id: Q8YEL1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

224914:BME RS07205
gene id: 224914:BME_RS07205
uniprot id: Q8YFT0
names: Function
names: Similarity
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: May be required for disulfide bond formation in some proteins.

224914:BME RS05885
gene id: 224914:BME_RS05885
uniprot id: Q8YGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

224914:BME RS05970
gene id: 224914:BME_RS05970
uniprot id: Q8YGH3
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

224914:BME RS00340
gene id: 224914:BME_RS00340
uniprot id: P65744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

224914:BME RS03860
gene id: 224914:BME_RS03860
uniprot id: Q8YHM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

224914:BME RS05795
gene id: 224914:BME_RS05795
uniprot id: Q8YGK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS00785
gene id: 224914:BME_RS00785
uniprot id: Q8YJC0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

224914:BME RS02865
gene id: 224914:BME_RS02865
uniprot id: P64255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

224914:BME RS00035
gene id: 224914:BME_RS00035
uniprot id: Q8YJS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

224914:BME RS04200
gene id: 224914:BME_RS04200
uniprot id: Q8YHG0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

224914:BME RS01065
gene id: 224914:BME_RS01065
uniprot id: Q8YJ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

224914:BME RS05395
gene id: 224914:BME_RS05395
uniprot id: P0A4Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

224914:BME RS13305
gene id: 224914:BME_RS13305
uniprot id: Q8YC93
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS05315
gene id: 224914:BME_RS05315
uniprot id: Q8YGU5
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

224914:BME RS08950
gene id: 224914:BME_RS08950
uniprot id: P67586
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

224914:BME RS07320
gene id: 224914:BME_RS07320
uniprot id: Q8YFQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

224914:BME RS11690
gene id: 224914:BME_RS11690
uniprot id: Q8YD73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

224914:BME RS15040
gene id: 224914:BME_RS15040
uniprot id: Q8YBA2
names: Subcellular Location Annotation
messages: Cell membrane

224914:BME RS07485
gene id: 224914:BME_RS07485
uniprot id: Q8YFM1
names: Similarity
messages: Belongs to the pirin family.

224914:BME RS11340
gene id: 224914:BME_RS11340
uniprot id: Q8YDE4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

224914:BME RS05150
gene id: 224914:BME_RS05150
uniprot id: Q8YGX6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224914:BME RS12575
gene id: 224914:BME_RS12575
uniprot id: Q8YCN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).

224914:BME RS02630
gene id: 224914:BME_RS02630
uniprot id: Q8YIB9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS12890
gene id: 224914:BME_RS12890
uniprot id: Q7CNS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport (By similarity).

224914:BME RS08720
gene id: 224914:BME_RS08720
uniprot id: Q8YEX0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS02435
gene id: 224914:BME_RS02435
uniprot id: Q8YIF8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

224914:BME RS14820
gene id: 224914:BME_RS14820
uniprot id: Q8YBE7
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03250
gene id: 224914:BME_RS03250
uniprot id: Q8YHY9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

224914:BME RS05075
gene id: 224914:BME_RS05075
uniprot id: Q8YGZ1
names: Similarity
messages: Belongs to the YkuD family.

224914:BME RS14015
gene id: 224914:BME_RS14015
uniprot id: Q8YBV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

224914:BME RS11835
gene id: 224914:BME_RS11835
uniprot id: Q8YD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

224914:BME RS08315
gene id: 224914:BME_RS08315
uniprot id: P62923
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

224914:BME RS05180
gene id: 224914:BME_RS05180
uniprot id: Q8YGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

224914:BME RS02010
gene id: 224914:BME_RS02010
uniprot id: Q8YIP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224914:BME RS12240
gene id: 224914:BME_RS12240
uniprot id: Q8YCV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

224914:BME RS03495
gene id: 224914:BME_RS03495
uniprot id: Q8YHU1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

224914:BME RS12505
gene id: 224914:BME_RS12505
uniprot id: Q8YCQ4
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

224914:BME RS02200
gene id: 224914:BME_RS02200
uniprot id: Q8YIK5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS09655
gene id: 224914:BME_RS09655
uniprot id: Q8YEC8
names: Similarity
messages: Belongs to the peptidase C40 family.

224914:BME RS03225
gene id: 224914:BME_RS03225
uniprot id: Q8YHZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

224914:BME RS14430
gene id: 224914:BME_RS14430
uniprot id: Q8YBN2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

224914:BME RS03835
gene id: 224914:BME_RS03835
uniprot id: Q8YHM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

224914:BME RS07785
gene id: 224914:BME_RS07785
uniprot id: Q8YFF8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Cell membrane
messages: Membrane

224914:BME RS09305
gene id: 224914:BME_RS09305
uniprot id: Q8YEK1
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS03035
gene id: 224914:BME_RS03035
uniprot id: Q8YI36
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

224914:BME RS00100
gene id: 224914:BME_RS00100
uniprot id: Q8YJR1
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons.

224914:BME RS08170
gene id: 224914:BME_RS08170
uniprot id: Q8YF82
names: Similarity
messages: Belongs to the Nudix hydrolase family.

224914:BME RS01870
gene id: 224914:BME_RS01870
uniprot id: Q8YIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Monomer.

224914:BME RS07940
gene id: 224914:BME_RS07940
uniprot id: Q8YFC9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

224914:BME RS00500
gene id: 224914:BME_RS00500
uniprot id: Q8YJH5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS11330
gene id: 224914:BME_RS11330
uniprot id: Q8YDE6
names: Similarity
messages: Belongs to the SlyX family.

224914:BME RS15655
gene id: 224914:BME_RS15655
uniprot id: Q8YAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS00655
gene id: 224914:BME_RS00655
uniprot id: Q8YJE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

224914:BME RS12015
gene id: 224914:BME_RS12015
uniprot id: Q8YD04
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

224914:BME RS06310
gene id: 224914:BME_RS06310
uniprot id: Q8YGA7
names: Similarity
messages: Belongs to the MoaD family.

224914:BME RS05060
gene id: 224914:BME_RS05060
uniprot id: Q8YGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

224914:BME RS05220
gene id: 224914:BME_RS05220
uniprot id: Q8YGW2
names: Function
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.

224914:BME RS03505
gene id: 224914:BME_RS03505
uniprot id: Q8YHT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

224914:BME RS13945
gene id: 224914:BME_RS13945
uniprot id: Q8YBW8
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS12185
gene id: 224914:BME_RS12185
uniprot id: Q8YCX2
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS07085
gene id: 224914:BME_RS07085
uniprot id: F8WJX8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS01630
gene id: 224914:BME_RS01630
uniprot id: F8WJN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

224914:BME RS14410
gene id: 224914:BME_RS14410
uniprot id: Q8YBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859).

224914:BME RS07780
gene id: 224914:BME_RS07780
uniprot id: Q8YFF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

224914:BME RS04680
gene id: 224914:BME_RS04680
uniprot id: Q8YH64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell inner membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

224914:BME RS03440
gene id: 224914:BME_RS03440
uniprot id: Q8YHV2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

224914:BME RS13445
gene id: 224914:BME_RS13445
uniprot id: Q8YC67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

224914:BME RS01420
gene id: 224914:BME_RS01420
uniprot id: Q8YIZ5
names: Similarity
messages: Belongs to the pyruvate kinase family.

224914:BME RS10975
gene id: 224914:BME_RS10975
uniprot id: Q8YDL1
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

224914:BME RS14565
gene id: 224914:BME_RS14565
uniprot id: P0A326
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Homotetramer.
messages: Periplasm

224914:BME RS08840
gene id: 224914:BME_RS08840
uniprot id: Q8YEU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

224914:BME RS07730
gene id: 224914:BME_RS07730
uniprot id: Q8YFH1
names: Similarity
messages: Belongs to the YfgM family.

224914:BME RS03725
gene id: 224914:BME_RS03725
uniprot id: Q8YHQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

224914:BME RS15705
gene id: 224914:BME_RS15705
uniprot id: Q8YAW9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS05440
gene id: 224914:BME_RS05440
uniprot id: P66887
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

224914:BME RS02570
gene id: 224914:BME_RS02570
uniprot id: Q8YID2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

224914:BME RS08810
gene id: 224914:BME_RS08810
uniprot id: Q8YEV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

224914:BME RS08320
gene id: 224914:BME_RS08320
uniprot id: Q8YF55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

224914:BME RS05755
gene id: 224914:BME_RS05755
uniprot id: Q8YGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS09570
gene id: 224914:BME_RS09570
uniprot id: Q8YEE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS04130
gene id: 224914:BME_RS04130
uniprot id: Q8YHH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

224914:BME RS02080
gene id: 224914:BME_RS02080
uniprot id: Q8YIM6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn regulates CtrA, a transcriptional regulator of the minB operon. The asymmetrical localization of this protein is probably required for cells to enter a new division cycle (By similarity).
messages: Interacts with DivK.

224914:BME RS06750
gene id: 224914:BME_RS06750
uniprot id: Q8YG20
names: Similarity
messages: Belongs to the peptidase C40 family.

224914:BME RS03715
gene id: 224914:BME_RS03715
uniprot id: Q8YHQ2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

224914:BME RS08185
gene id: 224914:BME_RS08185
uniprot id: Q8YF78
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

224914:BME RS00990
gene id: 224914:BME_RS00990
uniprot id: Q8YJ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

224914:BME RS08625
gene id: 224914:BME_RS08625
uniprot id: Q8YEZ1
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.

224914:BME RS00255
gene id: 224914:BME_RS00255
uniprot id: Q8YJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

224914:BME RS09715
gene id: 224914:BME_RS09715
uniprot id: Q8YEB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

224914:BME RS02810
gene id: 224914:BME_RS02810
uniprot id: Q8YI83
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

224914:BME RS03140
gene id: 224914:BME_RS03140
uniprot id: Q8YI15
names: Similarity
messages: Belongs to the PhzF family.

224914:BME RS03095
gene id: 224914:BME_RS03095
uniprot id: Q8YI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

224914:BME RS03735
gene id: 224914:BME_RS03735
uniprot id: P0A468
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

224914:BME RS02195
gene id: 224914:BME_RS02195
uniprot id: Q8YIK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

224914:BME RS06020
gene id: 224914:BME_RS06020
uniprot id: Q8YGG2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

224914:BME RS04070
gene id: 224914:BME_RS04070
uniprot id: Q8YHI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

224914:BME RS06710
gene id: 224914:BME_RS06710
uniprot id: Q8YG29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

224914:BME RS09695
gene id: 224914:BME_RS09695
uniprot id: Q8YEC0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

224914:BME RS09580
gene id: 224914:BME_RS09580
uniprot id: Q8YEE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS04855
gene id: 224914:BME_RS04855
uniprot id: Q8YH30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

224914:BME RS08210
gene id: 224914:BME_RS08210
uniprot id: Q7CNT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

224914:BME RS10095
gene id: 224914:BME_RS10095
uniprot id: P63808
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

224914:BME RS15130
gene id: 224914:BME_RS15130
uniprot id: Q8YB85
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

224914:BME RS05775
gene id: 224914:BME_RS05775
uniprot id: Q8YGK6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS03825
gene id: 224914:BME_RS03825
uniprot id: Q8YHN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

224914:BME RS09690
gene id: 224914:BME_RS09690
uniprot id: Q8YEC1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

224914:BME RS12290
gene id: 224914:BME_RS12290
uniprot id: Q8YCU9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

224914:BME RS09925
gene id: 224914:BME_RS09925
uniprot id: Q8YE73
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224914:BME RS09240
gene id: 224914:BME_RS09240
uniprot id: Q8YEL3
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS15270
gene id: 224914:BME_RS15270
uniprot id: Q8YB56
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

224914:BME RS03330
gene id: 224914:BME_RS03330
uniprot id: Q8YHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

224914:BME RS15430
gene id: 224914:BME_RS15430
uniprot id: Q8YB24
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224914:BME RS11405
gene id: 224914:BME_RS11405
uniprot id: Q8YDC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

224914:BME RS11230
gene id: 224914:BME_RS11230
uniprot id: Q8YDG4
names: Similarity
messages: Belongs to the peptidase S45 family.

224914:BME RS10685
gene id: 224914:BME_RS10685
uniprot id: Q8YDS2
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

224914:BME RS05115
gene id: 224914:BME_RS05115
uniprot id: Q8YGY3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

224914:BME RS14835
gene id: 224914:BME_RS14835
uniprot id: Q8YBE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224914:BME RS15310
gene id: 224914:BME_RS15310
uniprot id: Q8YB48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.

224914:BME RS07450
gene id: 224914:BME_RS07450
uniprot id: Q8YFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

224914:BME RS03510
gene id: 224914:BME_RS03510
uniprot id: Q8YHT8
names: Function
messages: Component of an amino-acid transport system.

224914:BME RS09920
gene id: 224914:BME_RS09920
uniprot id: Q8YE74
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224914:BME RS14715
gene id: 224914:BME_RS14715
uniprot id: P65361
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

224914:BME RS07830
gene id: 224914:BME_RS07830
uniprot id: Q8YFF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

224914:BME RS13400
gene id: 224914:BME_RS13400
uniprot id: Q8YC76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

224914:BME RS02885
gene id: 224914:BME_RS02885
uniprot id: P65468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

224914:BME RS06050
gene id: 224914:BME_RS06050
uniprot id: Q8YGF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

224914:BME RS07905
gene id: 224914:BME_RS07905
uniprot id: Q8YFD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell inner membrane
messages: Multidrug efflux pump.

224914:BME RS02070
gene id: 224914:BME_RS02070
uniprot id: Q8YIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS14025
gene id: 224914:BME_RS14025
uniprot id: Q8YBV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

224914:BME RS08820
gene id: 224914:BME_RS08820
uniprot id: Q8YEV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

224914:BME RS07385
gene id: 224914:BME_RS07385
uniprot id: Q8YFP2
names: Similarity
messages: Belongs to the fabD family.

224914:BME RS05740
gene id: 224914:BME_RS05740
uniprot id: Q8YGL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224914:BME RS10710
gene id: 224914:BME_RS10710
uniprot id: Q8YDR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably Responsible for energy coupling to the transport system (Probable).
messages: The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109).

224914:BME RS06545
gene id: 224914:BME_RS06545
uniprot id: Q8YG59
names: Similarity
messages: Belongs to the virb1 family.

224914:BME RS02945
gene id: 224914:BME_RS02945
uniprot id: Q8YI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

224914:BME RS11780
gene id: 224914:BME_RS11780
uniprot id: Q8YD52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

224914:BME RS11040
gene id: 224914:BME_RS11040
uniprot id: Q8YDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Part of the ATP-binding cassette (ABC) system ZnuABC involved in zinc import (By similarity). Binds zinc with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm (By similarity). Required for survival and normal growth under low Zn (2+) concentrations (By similarity). Also required for virulence and intracellular growth in host cells (By similarity).
messages: Periplasm

224914:BME RS00695
gene id: 224914:BME_RS00695
uniprot id: Q8YJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

224914:BME RS05945
gene id: 224914:BME_RS05945
uniprot id: Q8YGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

224914:BME RS12960
gene id: 224914:BME_RS12960
uniprot id: Q8YCG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).

224914:BME RS04840
gene id: 224914:BME_RS04840
uniprot id: Q8YH33
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

224914:BME RS01555
gene id: 224914:BME_RS01555
uniprot id: P67173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

224914:BME RS01860
gene id: 224914:BME_RS01860
uniprot id: Q8YIR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

224914:BME RS03880
gene id: 224914:BME_RS03880
uniprot id: Q8YHM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

224914:BME RS10980
gene id: 224914:BME_RS10980
uniprot id: Q8YDL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

224914:BME RS05860
gene id: 224914:BME_RS05860
uniprot id: Q8YGJ2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

224914:BME RS00470
gene id: 224914:BME_RS00470
uniprot id: Q8YJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

224914:BME RS11940
gene id: 224914:BME_RS11940
uniprot id: Q8YD19
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

224914:BME RS03110
gene id: 224914:BME_RS03110
uniprot id: Q8YI21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

224914:BME RS07695
gene id: 224914:BME_RS07695
uniprot id: Q8YFH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

224914:BME RS14230
gene id: 224914:BME_RS14230
uniprot id: F8WJP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

224914:BME RS09900
gene id: 224914:BME_RS09900
uniprot id: Q8YE77
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

224914:BME RS06955
gene id: 224914:BME_RS06955
uniprot id: Q8YFY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Binds 2 potassium ions per subunit.
messages: Dimer of dimers.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

224914:BME RS10330
gene id: 224914:BME_RS10330
uniprot id: Q8YDZ4
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

224914:BME RS00390
gene id: 224914:BME_RS00390
uniprot id: Q8YJJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

224914:BME RS10970
gene id: 224914:BME_RS10970
uniprot id: Q8YDL2
names: Caution
names: Function
names: Similarity
messages: Belongs to the FlbT family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.
messages: Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation.

224914:BME RS03070
gene id: 224914:BME_RS03070
uniprot id: Q8YI29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

224914:BME RS01745
gene id: 224914:BME_RS01745
uniprot id: P64004
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

224914:BME RS12085
gene id: 224914:BME_RS12085
uniprot id: Q8YCZ0
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

224914:BME RS10575
gene id: 224914:BME_RS10575
uniprot id: Q7CNT0
names: Cofactor
messages: Binds 1 phosphopantetheine covalently.

224914:BME RS03930
gene id: 224914:BME_RS03930
uniprot id: P65975
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

224914:BME RS07495
gene id: 224914:BME_RS07495
uniprot id: Q8YFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

224914:BME RS10740
gene id: 224914:BME_RS10740
uniprot id: Q8YDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

224914:BME RS04195
gene id: 224914:BME_RS04195
uniprot id: Q8YHG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

224914:BME RS12815
gene id: 224914:BME_RS12815
uniprot id: Q8YCI9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M81 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC).

224914:BME RS00515
gene id: 224914:BME_RS00515
uniprot id: Q8YJH2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

224914:BME RS09155
gene id: 224914:BME_RS09155
uniprot id: Q8YEM9
names: Similarity
messages: Belongs to the thioredoxin family. DsbE subfamily.

224914:BME RS01650
gene id: 224914:BME_RS01650
uniprot id: P0A3S7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The N-terminus is blocked.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

224914:BME RS14515
gene id: 224914:BME_RS14515
uniprot id: Q8YBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

224914:BME RS07815
gene id: 224914:BME_RS07815
uniprot id: Q8YFF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

224914:BME RS02860
gene id: 224914:BME_RS02860
uniprot id: Q8YI70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

224914:BME RS03600
gene id: 224914:BME_RS03600
uniprot id: Q8YHS2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

224914:BME RS15000
gene id: 224914:BME_RS15000
uniprot id: Q8YBB0
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS04110
gene id: 224914:BME_RS04110
uniprot id: Q8YHH6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

224914:BME RS08895
gene id: 224914:BME_RS08895
uniprot id: Q8YET3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

224914:BME RS11035
gene id: 224914:BME_RS11035
uniprot id: Q8YDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).

224914:BME RS07135
gene id: 224914:BME_RS07135
uniprot id: Q8YFU4
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS15920
gene id: 224914:BME_RS15920
uniprot id: P66286
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

224914:BME RS15415
gene id: 224914:BME_RS15415
uniprot id: Q8YB27
names: Similarity
messages: Belongs to the HpcH/HpaI aldolase family.

224914:BME RS07275
gene id: 224914:BME_RS07275
uniprot id: Q8YFR6
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

224914:BME RS04205
gene id: 224914:BME_RS04205
uniprot id: Q8YHF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

224914:BME RS09575
gene id: 224914:BME_RS09575
uniprot id: Q8YEE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

224914:BME RS07150
gene id: 224914:BME_RS07150
uniprot id: Q8YFU1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

224914:BME RS08165
gene id: 224914:BME_RS08165
uniprot id: Q8YF83
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

224914:BME RS02500
gene id: 224914:BME_RS02500
uniprot id: Q8YIE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport.
messages: Membrane

224914:BME RS01200
gene id: 224914:BME_RS01200
uniprot id: Q8YJ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

224914:BME RS06650
gene id: 224914:BME_RS06650
uniprot id: Q8YG41
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

224914:BME RS10610
gene id: 224914:BME_RS10610
uniprot id: Q8YDT9
names: Subcellular Location Annotation
messages: Membrane

224914:BME RS15160
gene id: 224914:BME_RS15160
uniprot id: Q8YB79
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

224914:BME RS12255
gene id: 224914:BME_RS12255
uniprot id: Q8YCV6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

224914:BME RS02915
gene id: 224914:BME_RS02915
uniprot id: Q8YI59
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

224914:BME RS06920
gene id: 224914:BME_RS06920
uniprot id: Q8YFY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

224914:BME RS08230
gene id: 224914:BME_RS08230
uniprot id: Q7CNT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

224914:BME RS08110
gene id: 224914:BME_RS08110
uniprot id: Q8YF93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224914:BME RS13940
gene id: 224914:BME_RS13940
uniprot id: Q8YBW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

224914:BME RS04300
gene id: 224914:BME_RS04300
uniprot id: Q8YHE0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

224914:BME RS07395
gene id: 224914:BME_RS07395
uniprot id: P66453
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

224914:BME RS15555
gene id: 224914:BME_RS15555
uniprot id: Q8YAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

224914:BME RS11160
gene id: 224914:BME_RS11160
uniprot id: Q8YDH9
names: Similarity
messages: Belongs to the amidase family.

224914:BME RS00745
gene id: 224914:BME_RS00745
uniprot id: Q8YJC9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

224914:BME RS03800
gene id: 224914:BME_RS03800
uniprot id: P66489
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

224914:BME RS14195
gene id: 224914:BME_RS14195
uniprot id: Q8YBR9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

224914:BME RS07885
gene id: 224914:BME_RS07885
uniprot id: Q8YFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

224914:BME RS00665
gene id: 224914:BME_RS00665
uniprot id: F8WJX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

224914:BME RS01635
gene id: 224914:BME_RS01635
uniprot id: Q8YIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

224914:BME RS13850
gene id: 224914:BME_RS13850
uniprot id: Q8YBY8
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

224914:BME RS03820
gene id: 224914:BME_RS03820
uniprot id: P66164
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

224914:BME RS06355
gene id: 224914:BME_RS06355
uniprot id: Q8YG98
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

224914:BME RS04745
gene id: 224914:BME_RS04745
uniprot id: Q8YH50
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

224914:BME RS02675
gene id: 224914:BME_RS02675
uniprot id: P0A3U8
names: Subcellular Location Annotation
messages: Periplasm

224914:BME RS02975
gene id: 224914:BME_RS02975
uniprot id: Q8YI47
names: Similarity
messages: Belongs to the UPF0303 family.

224914:BME RS09765
gene id: 224914:BME_RS09765
uniprot id: Q8YEA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane

224914:BME RS10005
gene id: 224914:BME_RS10005
uniprot id: Q8YE59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

224914:BME RS14625
gene id: 224914:BME_RS14625
uniprot id: Q8YBJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeA family.
messages: Periplasm
messages: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.

224914:BME RS03615
gene id: 224914:BME_RS03615
uniprot id: Q8YHR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

224914:BME RS13860
gene id: 224914:BME_RS13860
uniprot id: Q8YBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

224914:BME RS05230
gene id: 224914:BME_RS05230
uniprot id: Q8YGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

224914:BME RS09685
gene id: 224914:BME_RS09685
uniprot id: P64103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

224914:BME RS03870
gene id: 224914:BME_RS03870
uniprot id: Q8YHM2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

224914:BME RS12795
gene id: 224914:BME_RS12795
uniprot id: Q8YCJ5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224914:BME RS06480
gene id: 224914:BME_RS06480
uniprot id: P63464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.