2177:BHR79 RS06475
gene id: 2177:BHR79_RS06475
uniprot id: A0A1L3Q2R2
names: Similarity
messages: Belongs to the Ahb/Nir family.

2177:BHR79 RS06945
gene id: 2177:BHR79_RS06945
uniprot id: A0A1L3Q301
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2177:BHR79 RS04200
gene id: 2177:BHR79_RS04200
uniprot id: A0A1L3Q1K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2177:BHR79 RS06530
gene id: 2177:BHR79_RS06530
uniprot id: A0A1L3Q2Q9
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2177:BHR79 RS02060
gene id: 2177:BHR79_RS02060
uniprot id: A0A1L3Q0K1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS05290
gene id: 2177:BHR79_RS05290
uniprot id: A0A1L3Q256
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

2177:BHR79 RS04395
gene id: 2177:BHR79_RS04395
uniprot id: A0A1L3Q1N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

2177:BHR79 RS06550
gene id: 2177:BHR79_RS06550
uniprot id: A0A1L3Q2Q6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2177:BHR79 RS04070
gene id: 2177:BHR79_RS04070
uniprot id: A0A1L3Q1R4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

2177:BHR79 RS09440
gene id: 2177:BHR79_RS09440
uniprot id: A0A1L3Q458
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

2177:BHR79 RS02655
gene id: 2177:BHR79_RS02655
uniprot id: A0A1L3Q0V2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

2177:BHR79 RS08110
gene id: 2177:BHR79_RS08110
uniprot id: A0A1L3Q3S4
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

2177:BHR79 RS01885
gene id: 2177:BHR79_RS01885
uniprot id: A0A1L3Q0F1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

2177:BHR79 RS00860
gene id: 2177:BHR79_RS00860
uniprot id: A0A1L3PZW1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

2177:BHR79 RS01555
gene id: 2177:BHR79_RS01555
uniprot id: A0A1L3Q0A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

2177:BHR79 RS05195
gene id: 2177:BHR79_RS05195
uniprot id: A0A1L3Q228
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03410
gene id: 2177:BHR79_RS03410
uniprot id: A0A1L3Q164
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

2177:BHR79 RS09420
gene id: 2177:BHR79_RS09420
uniprot id: A0A1L3Q559
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

2177:BHR79 RS00550
gene id: 2177:BHR79_RS00550
uniprot id: A0A1L3PZQ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS02840
gene id: 2177:BHR79_RS02840
uniprot id: A0A1L3Q110
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

2177:BHR79 RS05715
gene id: 2177:BHR79_RS05715
uniprot id: A0A1L3Q2K0
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

2177:BHR79 RS05720
gene id: 2177:BHR79_RS05720
uniprot id: A0A1L3Q2B5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

2177:BHR79 RS06800
gene id: 2177:BHR79_RS06800
uniprot id: A0A1L3Q2W4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2177:BHR79 RS05315
gene id: 2177:BHR79_RS05315
uniprot id: A0A1L3Q247
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2177:BHR79 RS09140
gene id: 2177:BHR79_RS09140
uniprot id: A0A1L3Q409
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS08715
gene id: 2177:BHR79_RS08715
uniprot id: A0A1L3Q3S8
names: Similarity
messages: Belongs to the UPF0305 family.

2177:BHR79 RS07215
gene id: 2177:BHR79_RS07215
uniprot id: A0A1L3Q337
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS01695
gene id: 2177:BHR79_RS01695
uniprot id: A0A1L3Q0D2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

2177:BHR79 RS05840
gene id: 2177:BHR79_RS05840
uniprot id: A0A1L3Q2M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

2177:BHR79 RS04680
gene id: 2177:BHR79_RS04680
uniprot id: A0A1L3Q220
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

2177:BHR79 RS09380
gene id: 2177:BHR79_RS09380
uniprot id: A0A1L3Q452
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2177:BHR79 RS01050
gene id: 2177:BHR79_RS01050
uniprot id: A0A1L3Q004
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

2177:BHR79 RS00165
gene id: 2177:BHR79_RS00165
uniprot id: A0A1L3Q4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

2177:BHR79 RS00630
gene id: 2177:BHR79_RS00630
uniprot id: A0A1L3PZV0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

2177:BHR79 RS08065
gene id: 2177:BHR79_RS08065
uniprot id: A0A1L3Q3K9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

2177:BHR79 RS07940
gene id: 2177:BHR79_RS07940
uniprot id: A0A1L3Q3F3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS08565
gene id: 2177:BHR79_RS08565
uniprot id: A0A1L3Q406
names: Similarity
messages: Belongs to the peptidase U62 family.

2177:BHR79 RS05735
gene id: 2177:BHR79_RS05735
uniprot id: A0A3M9L9C7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS07010
gene id: 2177:BHR79_RS07010
uniprot id: A0A1L3Q2Z7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2177:BHR79 RS02600
gene id: 2177:BHR79_RS02600
uniprot id: A0A1L3Q0U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

2177:BHR79 RS06325
gene id: 2177:BHR79_RS06325
uniprot id: A0A1L3Q4Z8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

2177:BHR79 RS03545
gene id: 2177:BHR79_RS03545
uniprot id: A0A1L3Q194
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2177:BHR79 RS02025
gene id: 2177:BHR79_RS02025
uniprot id: A0A1L3Q0I3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

2177:BHR79 RS01365
gene id: 2177:BHR79_RS01365
uniprot id: A0A1L3Q059
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04815
gene id: 2177:BHR79_RS04815
uniprot id: A0A1L3Q1W7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

2177:BHR79 RS03740
gene id: 2177:BHR79_RS03740
uniprot id: A0A1L3Q1G1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

2177:BHR79 RS02400
gene id: 2177:BHR79_RS02400
uniprot id: A0A1L3Q0P3
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

2177:BHR79 RS07540
gene id: 2177:BHR79_RS07540
uniprot id: A0A1H2TYC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

2177:BHR79 RS05730
gene id: 2177:BHR79_RS05730
uniprot id: A0A1L3Q2C4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

2177:BHR79 RS07395
gene id: 2177:BHR79_RS07395
uniprot id: A0A1L3Q370
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2177:BHR79 RS04855
gene id: 2177:BHR79_RS04855
uniprot id: A0A1L3Q1W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS05590
gene id: 2177:BHR79_RS05590
uniprot id: A0A1L3Q4U7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

2177:BHR79 RS08080
gene id: 2177:BHR79_RS08080
uniprot id: A0A1L3Q3J3
names: Similarity
messages: Belongs to the UPF0282 family.

2177:BHR79 RS05480
gene id: 2177:BHR79_RS05480
uniprot id: A0A1L3Q2C1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2177:BHR79 RS08730
gene id: 2177:BHR79_RS08730
uniprot id: A0A1L3Q3U3
names: Similarity
messages: Belongs to the UPF0210 family.

2177:BHR79 RS06540
gene id: 2177:BHR79_RS06540
uniprot id: A0A1L3Q2T2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

2177:BHR79 RS06805
gene id: 2177:BHR79_RS06805
uniprot id: A0A1L3Q2X0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

2177:BHR79 RS06615
gene id: 2177:BHR79_RS06615
uniprot id: A0A1L3Q2R7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

2177:BHR79 RS02415
gene id: 2177:BHR79_RS02415
uniprot id: A0A1L3Q0N5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

2177:BHR79 RS01515
gene id: 2177:BHR79_RS01515
uniprot id: A0A1L3Q0A9
names: Similarity
messages: Belongs to the MtxX family.

2177:BHR79 RS01705
gene id: 2177:BHR79_RS01705
uniprot id: A0A1L3Q0M2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2177:BHR79 RS08535
gene id: 2177:BHR79_RS08535
uniprot id: A0A1L3Q3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

2177:BHR79 RS05170
gene id: 2177:BHR79_RS05170
uniprot id: A0A1L3Q229
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03125
gene id: 2177:BHR79_RS03125
uniprot id: A0A1L3Q121
names: Similarity
messages: Belongs to the UPF0175 family.

2177:BHR79 RS06755
gene id: 2177:BHR79_RS06755
uniprot id: A0A1L3Q2W7
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

2177:BHR79 RS08880
gene id: 2177:BHR79_RS08880
uniprot id: A0A1L3Q3V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

2177:BHR79 RS06675
gene id: 2177:BHR79_RS06675
uniprot id: A0A1L3Q2V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2177:BHR79 RS04505
gene id: 2177:BHR79_RS04505
uniprot id: A0A1L3Q1T1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

2177:BHR79 RS04665
gene id: 2177:BHR79_RS04665
uniprot id: A0A1L3Q1T9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS06685
gene id: 2177:BHR79_RS06685
uniprot id: A0A1L3Q2U9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

2177:BHR79 RS05910
gene id: 2177:BHR79_RS05910
uniprot id: A0A1L3Q2I1
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS05845
gene id: 2177:BHR79_RS05845
uniprot id: A0A1L3Q2D7
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04245
gene id: 2177:BHR79_RS04245
uniprot id: A0A1L3Q1Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

2177:BHR79 RS03400
gene id: 2177:BHR79_RS03400
uniprot id: A0A1L3Q167
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

2177:BHR79 RS10070
gene id: 2177:BHR79_RS10070
uniprot id: A0A1L3Q523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

2177:BHR79 RS06060
gene id: 2177:BHR79_RS06060
uniprot id: A0A1L3Q2I9
names: Similarity
messages: Belongs to the MEMO1 family.

2177:BHR79 RS09365
gene id: 2177:BHR79_RS09365
uniprot id: A0A1L3Q4G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

2177:BHR79 RS01920
gene id: 2177:BHR79_RS01920
uniprot id: A0A1L3Q0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2177:BHR79 RS08490
gene id: 2177:BHR79_RS08490
uniprot id: A0A1L3Q3N7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

2177:BHR79 RS06390
gene id: 2177:BHR79_RS06390
uniprot id: A0A1L3Q2Q3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS10135
gene id: 2177:BHR79_RS10135
uniprot id: A0A1L3Q4H7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS04785
gene id: 2177:BHR79_RS04785
uniprot id: A0A1L3Q1V7
names: Similarity
messages: Belongs to the glutamate synthase family.

2177:BHR79 RS02540
gene id: 2177:BHR79_RS02540
uniprot id: A0A1L3Q0S7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

2177:BHR79 RS06865
gene id: 2177:BHR79_RS06865
uniprot id: A0A1L3Q2X9
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS05495
gene id: 2177:BHR79_RS05495
uniprot id: A0A1L3Q2B1
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

2177:BHR79 RS06920
gene id: 2177:BHR79_RS06920
uniprot id: A0A1L3Q302
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

2177:BHR79 RS05060
gene id: 2177:BHR79_RS05060
uniprot id: A0A1H2VFQ9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

2177:BHR79 RS06655
gene id: 2177:BHR79_RS06655
uniprot id: A0A1L3Q310
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

2177:BHR79 RS09985
gene id: 2177:BHR79_RS09985
uniprot id: A0A1L3Q4E4
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

2177:BHR79 RS04615
gene id: 2177:BHR79_RS04615
uniprot id: A0A1L3Q1S8
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS07635
gene id: 2177:BHR79_RS07635
uniprot id: A0A1L3Q388
names: Subcellular Location Annotation
messages: Cytoplasm

2177:BHR79 RS09885
gene id: 2177:BHR79_RS09885
uniprot id: A0A1L3Q4G9
names: Similarity
messages: Belongs to the P(II) protein family.

2177:BHR79 RS07505
gene id: 2177:BHR79_RS07505
uniprot id: A0A1L3Q393
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

2177:BHR79 RS06515
gene id: 2177:BHR79_RS06515
uniprot id: A0A1L3Q2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

2177:BHR79 RS00685
gene id: 2177:BHR79_RS00685
uniprot id: A0A1L3PZT5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

2177:BHR79 RS05830
gene id: 2177:BHR79_RS05830
uniprot id: A0A1L3Q2F1
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04805
gene id: 2177:BHR79_RS04805
uniprot id: A0A1L3Q204
names: Similarity
messages: Belongs to the HdrB family.

2177:BHR79 RS09395
gene id: 2177:BHR79_RS09395
uniprot id: A0A1L3Q448
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

2177:BHR79 RS09255
gene id: 2177:BHR79_RS09255
uniprot id: A0A1L3Q4E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2177:BHR79 RS06975
gene id: 2177:BHR79_RS06975
uniprot id: A0A1L3Q589
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2177:BHR79 RS02355
gene id: 2177:BHR79_RS02355
uniprot id: A0A1L3Q0M8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS00620
gene id: 2177:BHR79_RS00620
uniprot id: A0A1L3PZS6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

2177:BHR79 RS01550
gene id: 2177:BHR79_RS01550
uniprot id: A0A1L3Q091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2177:BHR79 RS01355
gene id: 2177:BHR79_RS01355
uniprot id: A0A1L3Q048
names: Subunit
messages: Homotetramer.

2177:BHR79 RS04935
gene id: 2177:BHR79_RS04935
uniprot id: A0A1L3Q1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS08870
gene id: 2177:BHR79_RS08870
uniprot id: A0A1L3Q3V9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

2177:BHR79 RS02030
gene id: 2177:BHR79_RS02030
uniprot id: A0A1L3Q0I7
names: Similarity
messages: Belongs to the UPF0215 family.

2177:BHR79 RS09705
gene id: 2177:BHR79_RS09705
uniprot id: A0A1L3Q4A5
names: Similarity
messages: Belongs to the UPF0284 family.

2177:BHR79 RS00915
gene id: 2177:BHR79_RS00915
uniprot id: A0A1L3PZX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

2177:BHR79 RS07575
gene id: 2177:BHR79_RS07575
uniprot id: A0A1L3Q3A4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

2177:BHR79 RS07175
gene id: 2177:BHR79_RS07175
uniprot id: A0A1H2U854
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

2177:BHR79 RS07315
gene id: 2177:BHR79_RS07315
uniprot id: A0A1L3Q347
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

2177:BHR79 RS03200
gene id: 2177:BHR79_RS03200
uniprot id: A0A1L3Q127
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

2177:BHR79 RS02500
gene id: 2177:BHR79_RS02500
uniprot id: A0A1L3Q0Z5
names: Similarity
messages: Belongs to the UPF0235 family.

2177:BHR79 RS02850
gene id: 2177:BHR79_RS02850
uniprot id: A0A1L3Q0Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

2177:BHR79 RS04065
gene id: 2177:BHR79_RS04065
uniprot id: A0A1L3Q1K1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

2177:BHR79 RS08560
gene id: 2177:BHR79_RS08560
uniprot id: A0A1L3Q3T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2177:BHR79 RS08785
gene id: 2177:BHR79_RS08785
uniprot id: A0A1L3Q3X1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS02720
gene id: 2177:BHR79_RS02720
uniprot id: A0A1L3Q0V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

2177:BHR79 RS06520
gene id: 2177:BHR79_RS06520
uniprot id: A0A1L3Q2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

2177:BHR79 RS09610
gene id: 2177:BHR79_RS09610
uniprot id: A0A1L3Q486
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

2177:BHR79 RS05870
gene id: 2177:BHR79_RS05870
uniprot id: A0A1L3Q2F6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS10055
gene id: 2177:BHR79_RS10055
uniprot id: A0A1L3Q4F8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS01070
gene id: 2177:BHR79_RS01070
uniprot id: A0A1L3Q005
names: Similarity
messages: Belongs to the peptidase C56 family.

2177:BHR79 RS07515
gene id: 2177:BHR79_RS07515
uniprot id: A0A3M9L8U1
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS09735
gene id: 2177:BHR79_RS09735
uniprot id: A0A1L3Q4A9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

2177:BHR79 RS04845
gene id: 2177:BHR79_RS04845
uniprot id: A0A1L3Q1Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS09385
gene id: 2177:BHR79_RS09385
uniprot id: A0A1L3Q483
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS09190
gene id: 2177:BHR79_RS09190
uniprot id: A0A1L3Q429
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

2177:BHR79 RS05180
gene id: 2177:BHR79_RS05180
uniprot id: A0A1L3Q4T2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS06690
gene id: 2177:BHR79_RS06690
uniprot id: A0A1L3Q2T8
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

2177:BHR79 RS01350
gene id: 2177:BHR79_RS01350
uniprot id: A0A1L3Q057
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

2177:BHR79 RS00455
gene id: 2177:BHR79_RS00455
uniprot id: A0A1L3PZP5
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS09860
gene id: 2177:BHR79_RS09860
uniprot id: A0A3M9L856
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS09390
gene id: 2177:BHR79_RS09390
uniprot id: A0A1L3Q456
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

2177:BHR79 RS00980
gene id: 2177:BHR79_RS00980
uniprot id: A0A1L3PZY6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

2177:BHR79 RS02410
gene id: 2177:BHR79_RS02410
uniprot id: A0A1L3Q0S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

2177:BHR79 RS02875
gene id: 2177:BHR79_RS02875
uniprot id: A0A1L3Q0Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

2177:BHR79 RS09690
gene id: 2177:BHR79_RS09690
uniprot id: A0A1L3Q4A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

2177:BHR79 RS03255
gene id: 2177:BHR79_RS03255
uniprot id: A0A1L3Q141
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS02335
gene id: 2177:BHR79_RS02335
uniprot id: A0A1L3Q4N0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

2177:BHR79 RS09640
gene id: 2177:BHR79_RS09640
uniprot id: A0A1L3Q4A4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

2177:BHR79 RS05285
gene id: 2177:BHR79_RS05285
uniprot id: A0A1L3Q243
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

2177:BHR79 RS10275
gene id: 2177:BHR79_RS10275
uniprot id: A0A1L3Q4J4
names: Similarity
messages: Belongs to the UPF0147 family.

2177:BHR79 RS06440
gene id: 2177:BHR79_RS06440
uniprot id: A0A1L3Q2T3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

2177:BHR79 RS02425
gene id: 2177:BHR79_RS02425
uniprot id: A0A1L3Q0P7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

2177:BHR79 RS02370
gene id: 2177:BHR79_RS02370
uniprot id: A0A1L3Q0P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

2177:BHR79 RS01980
gene id: 2177:BHR79_RS01980
uniprot id: A0A1L3Q0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

2177:BHR79 RS07570
gene id: 2177:BHR79_RS07570
uniprot id: A0A1H2TZV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

2177:BHR79 RS03735
gene id: 2177:BHR79_RS03735
uniprot id: A0A1L3Q1C3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS10215
gene id: 2177:BHR79_RS10215
uniprot id: A0A1L3Q4I7
names: Similarity
messages: Belongs to the UPF0285 family.

2177:BHR79 RS05790
gene id: 2177:BHR79_RS05790
uniprot id: A0A1L3Q2G1
names: Similarity
messages: Belongs to the complex I subunit 3 family.

2177:BHR79 RS00290
gene id: 2177:BHR79_RS00290
uniprot id: A0A1L3PZP3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

2177:BHR79 RS06260
gene id: 2177:BHR79_RS06260
uniprot id: A0A1L3Q2Q4
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

2177:BHR79 RS02605
gene id: 2177:BHR79_RS02605
uniprot id: A0A1L3Q114
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

2177:BHR79 RS05745
gene id: 2177:BHR79_RS05745
uniprot id: A0A1L3Q2B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

2177:BHR79 RS10040
gene id: 2177:BHR79_RS10040
uniprot id: A0A1L3Q4F5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS00350
gene id: 2177:BHR79_RS00350
uniprot id: A0A1L3PZZ8
names: Similarity
messages: Belongs to the GARS family.

2177:BHR79 RS05130
gene id: 2177:BHR79_RS05130
uniprot id: A0A1L3Q2A0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

2177:BHR79 RS07025
gene id: 2177:BHR79_RS07025
uniprot id: A0A1L3Q312
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2177:BHR79 RS09340
gene id: 2177:BHR79_RS09340
uniprot id: A0A1L3Q447
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

2177:BHR79 RS03870
gene id: 2177:BHR79_RS03870
uniprot id: A0A1L3Q1F7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2177:BHR79 RS07605
gene id: 2177:BHR79_RS07605
uniprot id: A0A1L3Q3B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

2177:BHR79 RS08145
gene id: 2177:BHR79_RS08145
uniprot id: A0A1L3Q3J2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

2177:BHR79 RS06705
gene id: 2177:BHR79_RS06705
uniprot id: A0A1L3Q320
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07080
gene id: 2177:BHR79_RS07080
uniprot id: A0A1L3Q314
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS10850
gene id: 2177:BHR79_RS10850
uniprot id: A0A1L3Q473
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03645
gene id: 2177:BHR79_RS03645
uniprot id: A0A1L3Q1A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

2177:BHR79 RS07585
gene id: 2177:BHR79_RS07585
uniprot id: A0A1L3Q4X5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

2177:BHR79 RS01575
gene id: 2177:BHR79_RS01575
uniprot id: A0A1L3Q087
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS03210
gene id: 2177:BHR79_RS03210
uniprot id: A0A1L3Q143
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS04540
gene id: 2177:BHR79_RS04540
uniprot id: A0A1L3Q4V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS05595
gene id: 2177:BHR79_RS05595
uniprot id: A0A1L3Q2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

2177:BHR79 RS04260
gene id: 2177:BHR79_RS04260
uniprot id: A0A1L3Q1L3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS01560
gene id: 2177:BHR79_RS01560
uniprot id: A0A1L3Q095
names: Similarity
messages: Belongs to the ClpA/ClpB family.

2177:BHR79 RS05670
gene id: 2177:BHR79_RS05670
uniprot id: A0A1L3Q2B3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07705
gene id: 2177:BHR79_RS07705
uniprot id: A0A1L3Q3A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

2177:BHR79 RS09475
gene id: 2177:BHR79_RS09475
uniprot id: A0A1L3Q465
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

2177:BHR79 RS03770
gene id: 2177:BHR79_RS03770
uniprot id: A0A1L3Q1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

2177:BHR79 RS05490
gene id: 2177:BHR79_RS05490
uniprot id: A0A1L3Q282
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

2177:BHR79 RS06980
gene id: 2177:BHR79_RS06980
uniprot id: A0A1L3Q309
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS03360
gene id: 2177:BHR79_RS03360
uniprot id: A0A1L3Q154
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

2177:BHR79 RS02305
gene id: 2177:BHR79_RS02305
uniprot id: A0A1L3Q0N2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

2177:BHR79 RS07115
gene id: 2177:BHR79_RS07115
uniprot id: A0A1L3Q308
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

2177:BHR79 RS05555
gene id: 2177:BHR79_RS05555
uniprot id: A0A1L3Q2A2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

2177:BHR79 RS08090
gene id: 2177:BHR79_RS08090
uniprot id: A0A3M9L377
names: Caution
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS02700
gene id: 2177:BHR79_RS02700
uniprot id: A0A1L3Q0V3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

2177:BHR79 RS10045
gene id: 2177:BHR79_RS10045
uniprot id: A0A1L3Q4J1
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS00755
gene id: 2177:BHR79_RS00755
uniprot id: A0A3M9LET5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS01645
gene id: 2177:BHR79_RS01645
uniprot id: A0A1L3Q0C1
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

2177:BHR79 RS09135
gene id: 2177:BHR79_RS09135
uniprot id: A0A1L3Q4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

2177:BHR79 RS06930
gene id: 2177:BHR79_RS06930
uniprot id: A0A1L3Q2X8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2177:BHR79 RS02465
gene id: 2177:BHR79_RS02465
uniprot id: A0A1L3Q0S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

2177:BHR79 RS03275
gene id: 2177:BHR79_RS03275
uniprot id: A0A1L3Q1B8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2177:BHR79 RS05300
gene id: 2177:BHR79_RS05300
uniprot id: A0A1L3Q254
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

2177:BHR79 RS00590
gene id: 2177:BHR79_RS00590
uniprot id: A0A1L3PZS2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

2177:BHR79 RS04580
gene id: 2177:BHR79_RS04580
uniprot id: A0A1L3Q1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS00500
gene id: 2177:BHR79_RS00500
uniprot id: A0A1L3PZP7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

2177:BHR79 RS06780
gene id: 2177:BHR79_RS06780
uniprot id: A0A1L3Q2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

2177:BHR79 RS04015
gene id: 2177:BHR79_RS04015
uniprot id: A0A1L3Q1J4
names: Subcellular Location Annotation
messages: Cell membrane

2177:BHR79 RS00310
gene id: 2177:BHR79_RS00310
uniprot id: A0A1L3PZP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

2177:BHR79 RS06455
gene id: 2177:BHR79_RS06455
uniprot id: A0A1L3Q4V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

2177:BHR79 RS07580
gene id: 2177:BHR79_RS07580
uniprot id: A0A1L3Q383
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

2177:BHR79 RS10240
gene id: 2177:BHR79_RS10240
uniprot id: A0A1L3Q4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

2177:BHR79 RS02535
gene id: 2177:BHR79_RS02535
uniprot id: A0A1L3Q0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

2177:BHR79 RS00280
gene id: 2177:BHR79_RS00280
uniprot id: A0A1L3PZL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

2177:BHR79 RS03685
gene id: 2177:BHR79_RS03685
uniprot id: A0A1L3Q1F2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

2177:BHR79 RS05040
gene id: 2177:BHR79_RS05040
uniprot id: A0A1L3Q216
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

2177:BHR79 RS09330
gene id: 2177:BHR79_RS09330
uniprot id: A0A1L3Q472
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2177:BHR79 RS05760
gene id: 2177:BHR79_RS05760
uniprot id: A0A1L3Q2E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

2177:BHR79 RS06110
gene id: 2177:BHR79_RS06110
uniprot id: A0A1L3Q2I0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

2177:BHR79 RS05235
gene id: 2177:BHR79_RS05235
uniprot id: A0A1L3Q239
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2177:BHR79 RS09495
gene id: 2177:BHR79_RS09495
uniprot id: A0A1L3Q4B8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS02320
gene id: 2177:BHR79_RS02320
uniprot id: A0A1L3Q0M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2177:BHR79 RS07335
gene id: 2177:BHR79_RS07335
uniprot id: A0A1L3Q4Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

2177:BHR79 RS08020
gene id: 2177:BHR79_RS08020
uniprot id: A0A1L3Q3I3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS02775
gene id: 2177:BHR79_RS02775
uniprot id: A0A1L3Q100
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

2177:BHR79 RS06480
gene id: 2177:BHR79_RS06480
uniprot id: A0A1L3Q2S3
names: Similarity
messages: Belongs to the Ahb/Nir family.

2177:BHR79 RS01730
gene id: 2177:BHR79_RS01730
uniprot id: A0A1L3Q0E8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

2177:BHR79 RS02750
gene id: 2177:BHR79_RS02750
uniprot id: A0A1L3Q0V6
names: Similarity
messages: Belongs to the PurH family.

2177:BHR79 RS01890
gene id: 2177:BHR79_RS01890
uniprot id: A0A1L3Q0G8
names: Similarity
messages: Belongs to the UPF0251 family.

2177:BHR79 RS04350
gene id: 2177:BHR79_RS04350
uniprot id: A0A1L3Q1Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

2177:BHR79 RS00830
gene id: 2177:BHR79_RS00830
uniprot id: A0A1L3PZW4
names: Similarity
messages: Belongs to the AdoMet synthase family.

2177:BHR79 RS09505
gene id: 2177:BHR79_RS09505
uniprot id: A0A1L3Q4A2
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS09650
gene id: 2177:BHR79_RS09650
uniprot id: A0A1H2SXK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS07210
gene id: 2177:BHR79_RS07210
uniprot id: A0A1L3Q334
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03895
gene id: 2177:BHR79_RS03895
uniprot id: A0A1L3Q1F0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS07000
gene id: 2177:BHR79_RS07000
uniprot id: A0A1L3Q2Y8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS04510
gene id: 2177:BHR79_RS04510
uniprot id: A0A1L3Q1Z4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

2177:BHR79 RS04215
gene id: 2177:BHR79_RS04215
uniprot id: A0A1L3Q1L4
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS09335
gene id: 2177:BHR79_RS09335
uniprot id: A0A1L3Q534
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

2177:BHR79 RS00905
gene id: 2177:BHR79_RS00905
uniprot id: A0A1L3Q003
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

2177:BHR79 RS03630
gene id: 2177:BHR79_RS03630
uniprot id: A0A1L3Q1A4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

2177:BHR79 RS07630
gene id: 2177:BHR79_RS07630
uniprot id: A0A1L3Q3B3
names: Similarity
messages: Belongs to the glutaredoxin family.

2177:BHR79 RS09820
gene id: 2177:BHR79_RS09820
uniprot id: A0A1L3Q4F9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

2177:BHR79 RS05005
gene id: 2177:BHR79_RS05005
uniprot id: A0A1L3Q1Z8
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

2177:BHR79 RS03780
gene id: 2177:BHR79_RS03780
uniprot id: A0A1L3Q1L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

2177:BHR79 RS07925
gene id: 2177:BHR79_RS07925
uniprot id: A0A1L3Q4Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

2177:BHR79 RS05135
gene id: 2177:BHR79_RS05135
uniprot id: A0A1L3Q218
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

2177:BHR79 RS00970
gene id: 2177:BHR79_RS00970
uniprot id: A0A1L3PZZ4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS06040
gene id: 2177:BHR79_RS06040
uniprot id: A0A1L3Q2L5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS03650
gene id: 2177:BHR79_RS03650
uniprot id: A0A1L3Q1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

2177:BHR79 RS05265
gene id: 2177:BHR79_RS05265
uniprot id: A0A1L3Q237
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

2177:BHR79 RS03800
gene id: 2177:BHR79_RS03800
uniprot id: A0A1L3Q1F8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

2177:BHR79 RS02670
gene id: 2177:BHR79_RS02670
uniprot id: A0A1L3Q0Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

2177:BHR79 RS00385
gene id: 2177:BHR79_RS00385
uniprot id: A0A1L3PZP9
names: Similarity
messages: Belongs to the UPF0047 family.

2177:BHR79 RS01585
gene id: 2177:BHR79_RS01585
uniprot id: A0A1L3Q0B1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

2177:BHR79 RS02140
gene id: 2177:BHR79_RS02140
uniprot id: A0A1L3Q0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

2177:BHR79 RS08985
gene id: 2177:BHR79_RS08985
uniprot id: A0A1L3Q401
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

2177:BHR79 RS05645
gene id: 2177:BHR79_RS05645
uniprot id: A0A1L3Q2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2177:BHR79 RS06385
gene id: 2177:BHR79_RS06385
uniprot id: A0A1L3Q2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

2177:BHR79 RS09200
gene id: 2177:BHR79_RS09200
uniprot id: A0A1L3Q428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

2177:BHR79 RS09740
gene id: 2177:BHR79_RS09740
uniprot id: A0A1L3Q4A7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

2177:BHR79 RS06445
gene id: 2177:BHR79_RS06445
uniprot id: A0A1L3Q2N8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07075
gene id: 2177:BHR79_RS07075
uniprot id: A0A1L3Q311
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2177:BHR79 RS07740
gene id: 2177:BHR79_RS07740
uniprot id: A0A1L3Q3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

2177:BHR79 RS04850
gene id: 2177:BHR79_RS04850
uniprot id: A0A1L3Q251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS09675
gene id: 2177:BHR79_RS09675
uniprot id: A0A1L3Q4A0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

2177:BHR79 RS08000
gene id: 2177:BHR79_RS08000
uniprot id: A0A1L3Q3F1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

2177:BHR79 RS03625
gene id: 2177:BHR79_RS03625
uniprot id: A0A1L3Q1E1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

2177:BHR79 RS09435
gene id: 2177:BHR79_RS09435
uniprot id: A0A1L3Q4H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

2177:BHR79 RS07500
gene id: 2177:BHR79_RS07500
uniprot id: A0A1L3Q4Y2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

2177:BHR79 RS02590
gene id: 2177:BHR79_RS02590
uniprot id: A0A1L3Q0S5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

2177:BHR79 RS02610
gene id: 2177:BHR79_RS02610
uniprot id: A0A1L3Q0T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

2177:BHR79 RS04130
gene id: 2177:BHR79_RS04130
uniprot id: A0A1L3Q1J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS08765
gene id: 2177:BHR79_RS08765
uniprot id: A0A1L3Q3T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

2177:BHR79 RS01710
gene id: 2177:BHR79_RS01710
uniprot id: A0A1L3Q0C0
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

2177:BHR79 RS04085
gene id: 2177:BHR79_RS04085
uniprot id: A0A1L3Q1I5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

2177:BHR79 RS05905
gene id: 2177:BHR79_RS05905
uniprot id: A0A1L3Q2E9
names: Function
messages: Part of a potassium transport system.

2177:BHR79 RS01755
gene id: 2177:BHR79_RS01755
uniprot id: A0A1L3Q0E1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

2177:BHR79 RS10315
gene id: 2177:BHR79_RS10315
uniprot id: A0A1L3Q4K4
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

2177:BHR79 RS09485
gene id: 2177:BHR79_RS09485
uniprot id: A0A1L3Q4I9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

2177:BHR79 RS06120
gene id: 2177:BHR79_RS06120
uniprot id: A0A1L3Q2I5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

2177:BHR79 RS05065
gene id: 2177:BHR79_RS05065
uniprot id: A0A1L3Q232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS04700
gene id: 2177:BHR79_RS04700
uniprot id: A0A1L3Q1W1
names: Similarity
messages: Belongs to the archaeal-type GPI family.

2177:BHR79 RS09455
gene id: 2177:BHR79_RS09455
uniprot id: A0A1L3Q490
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2177:BHR79 RS02430
gene id: 2177:BHR79_RS02430
uniprot id: A0A1L3Q0R6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

2177:BHR79 RS06315
gene id: 2177:BHR79_RS06315
uniprot id: A0A1L3Q2L9
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS02615
gene id: 2177:BHR79_RS02615
uniprot id: A0A1L3Q0W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2177:BHR79 RS03215
gene id: 2177:BHR79_RS03215
uniprot id: A0A1L3Q1A9
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

2177:BHR79 RS06715
gene id: 2177:BHR79_RS06715
uniprot id: A0A1L3Q2Y1
names: Similarity
messages: Belongs to the UPF0179 family.

2177:BHR79 RS05440
gene id: 2177:BHR79_RS05440
uniprot id: A0A1L3Q270
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

2177:BHR79 RS05875
gene id: 2177:BHR79_RS05875
uniprot id: A0A1L3Q2E4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

2177:BHR79 RS05795
gene id: 2177:BHR79_RS05795
uniprot id: A0A1L3Q2C8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

2177:BHR79 RS07980
gene id: 2177:BHR79_RS07980
uniprot id: A0A1L3Q3G8
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS05390
gene id: 2177:BHR79_RS05390
uniprot id: A0A1L3Q275
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS02035
gene id: 2177:BHR79_RS02035
uniprot id: A0A1L3Q0H5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

2177:BHR79 RS03810
gene id: 2177:BHR79_RS03810
uniprot id: A0A1L3Q1D5
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

2177:BHR79 RS06450
gene id: 2177:BHR79_RS06450
uniprot id: A0A1L3Q2R4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

2177:BHR79 RS00795
gene id: 2177:BHR79_RS00795
uniprot id: A0A1L3PZV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS01260
gene id: 2177:BHR79_RS01260
uniprot id: A0A1L3Q041
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

2177:BHR79 RS01345
gene id: 2177:BHR79_RS01345
uniprot id: A0A1L3Q080
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

2177:BHR79 RS07610
gene id: 2177:BHR79_RS07610
uniprot id: A0A1L3Q3I4
names: Similarity
messages: Belongs to the TrpC family.

2177:BHR79 RS10035
gene id: 2177:BHR79_RS10035
uniprot id: A0A1L3Q4L9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS09900
gene id: 2177:BHR79_RS09900
uniprot id: A0A1L3Q4Q8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

2177:BHR79 RS01565
gene id: 2177:BHR79_RS01565
uniprot id: A0A1L3Q0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2177:BHR79 RS09545
gene id: 2177:BHR79_RS09545
uniprot id: A0A1L3Q4D3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS08005
gene id: 2177:BHR79_RS08005
uniprot id: A0A1L3Q3J6
names: Similarity
messages: Belongs to the DMRL synthase family.

2177:BHR79 RS02395
gene id: 2177:BHR79_RS02395
uniprot id: A0A1L3Q0T0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

2177:BHR79 RS01960
gene id: 2177:BHR79_RS01960
uniprot id: A0A1L3Q0H2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

2177:BHR79 RS07240
gene id: 2177:BHR79_RS07240
uniprot id: A0A1L3Q327
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

2177:BHR79 RS06050
gene id: 2177:BHR79_RS06050
uniprot id: A0A1L3Q2J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

2177:BHR79 RS07790
gene id: 2177:BHR79_RS07790
uniprot id: A0A1L3Q3F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

2177:BHR79 RS07485
gene id: 2177:BHR79_RS07485
uniprot id: A0A1L3Q3A9
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

2177:BHR79 RS03580
gene id: 2177:BHR79_RS03580
uniprot id: A0A1L3Q1B3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS00990
gene id: 2177:BHR79_RS00990
uniprot id: A0A1L3PZZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

2177:BHR79 RS07770
gene id: 2177:BHR79_RS07770
uniprot id: A0A1L3Q3C6
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

2177:BHR79 RS06095
gene id: 2177:BHR79_RS06095
uniprot id: A0A1L3Q2M6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

2177:BHR79 RS00230
gene id: 2177:BHR79_RS00230
uniprot id: A0A1L3PZK3
names: Similarity
messages: Belongs to the MCM family.

2177:BHR79 RS00105
gene id: 2177:BHR79_RS00105
uniprot id: A0A1L3PZH8
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

2177:BHR79 RS04310
gene id: 2177:BHR79_RS04310
uniprot id: A0A1L3Q1P3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07450
gene id: 2177:BHR79_RS07450
uniprot id: A0A1L3Q375
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

2177:BHR79 RS03925
gene id: 2177:BHR79_RS03925
uniprot id: A0A1L3Q1F6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS01720
gene id: 2177:BHR79_RS01720
uniprot id: A0A1L3Q0C5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

2177:BHR79 RS08760
gene id: 2177:BHR79_RS08760
uniprot id: A0A1L3Q3W0
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04325
gene id: 2177:BHR79_RS04325
uniprot id: A0A1L3Q1N7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07030
gene id: 2177:BHR79_RS07030
uniprot id: A0A1L3Q319
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2177:BHR79 RS07105
gene id: 2177:BHR79_RS07105
uniprot id: A0A1L3Q307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

2177:BHR79 RS01495
gene id: 2177:BHR79_RS01495
uniprot id: A0A1L3Q082
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS03725
gene id: 2177:BHR79_RS03725
uniprot id: A0A1L3Q1E3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS08265
gene id: 2177:BHR79_RS08265
uniprot id: A0A1L3Q507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

2177:BHR79 RS05510
gene id: 2177:BHR79_RS05510
uniprot id: A0A1L3Q286
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS00950
gene id: 2177:BHR79_RS00950
uniprot id: A0A1L3Q4L6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS02490
gene id: 2177:BHR79_RS02490
uniprot id: A0A1L3Q0S0
names: Similarity
messages: Belongs to the glutamate synthase family.

2177:BHR79 RS01990
gene id: 2177:BHR79_RS01990
uniprot id: A0A1L3Q0G9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2177:BHR79 RS02375
gene id: 2177:BHR79_RS02375
uniprot id: A0A1L3Q0Q8
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

2177:BHR79 RS05725
gene id: 2177:BHR79_RS05725
uniprot id: A0A1L3Q2G4
names: Function
messages: Part of a potassium transport system.

2177:BHR79 RS05125
gene id: 2177:BHR79_RS05125
uniprot id: A0A1L3Q244
names: Similarity
messages: Belongs to the UPF0166 family.

2177:BHR79 RS03660
gene id: 2177:BHR79_RS03660
uniprot id: A0A1L3Q1B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2177:BHR79 RS05190
gene id: 2177:BHR79_RS05190
uniprot id: A0A1L3Q2B0
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS00225
gene id: 2177:BHR79_RS00225
uniprot id: A0A1L3PZJ9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

2177:BHR79 RS00960
gene id: 2177:BHR79_RS00960
uniprot id: A0A1L3PZY5
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06025
gene id: 2177:BHR79_RS06025
uniprot id: A0A1L3Q2P5
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06490
gene id: 2177:BHR79_RS06490
uniprot id: A0A3M9L8Y2
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS06310
gene id: 2177:BHR79_RS06310
uniprot id: A0A1L3Q2V0
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07970
gene id: 2177:BHR79_RS07970
uniprot id: A0A1L3Q3F0
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

2177:BHR79 RS07200
gene id: 2177:BHR79_RS07200
uniprot id: A0A1L3Q339
names: Similarity
messages: Belongs to the class-I fumarase family.

2177:BHR79 RS01320
gene id: 2177:BHR79_RS01320
uniprot id: A0A1L3Q0G6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

2177:BHR79 RS03500
gene id: 2177:BHR79_RS03500
uniprot id: A0A1L3Q186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

2177:BHR79 RS00940
gene id: 2177:BHR79_RS00940
uniprot id: A0A1L3PZY3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04045
gene id: 2177:BHR79_RS04045
uniprot id: A0A1L3Q1G9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS00650
gene id: 2177:BHR79_RS00650
uniprot id: A0A1L3PZV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2177:BHR79 RS05545
gene id: 2177:BHR79_RS05545
uniprot id: A0A1L3Q2C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

2177:BHR79 RS05150
gene id: 2177:BHR79_RS05150
uniprot id: A0A1L3Q223
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS10250
gene id: 2177:BHR79_RS10250
uniprot id: A0A1L3Q4J3
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

2177:BHR79 RS02010
gene id: 2177:BHR79_RS02010
uniprot id: A0A1L3Q0I2
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

2177:BHR79 RS02015
gene id: 2177:BHR79_RS02015
uniprot id: A0A1L3Q0H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

2177:BHR79 RS01775
gene id: 2177:BHR79_RS01775
uniprot id: A0A1L3Q0F0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

2177:BHR79 RS03635
gene id: 2177:BHR79_RS03635
uniprot id: A0A1L3Q4X9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

2177:BHR79 RS02300
gene id: 2177:BHR79_RS02300
uniprot id: A0A1L3Q0N1
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

2177:BHR79 RS03505
gene id: 2177:BHR79_RS03505
uniprot id: A0A1L3Q1C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

2177:BHR79 RS07525
gene id: 2177:BHR79_RS07525
uniprot id: A0A1L3Q386
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

2177:BHR79 RS03945
gene id: 2177:BHR79_RS03945
uniprot id: A0A1L3Q1F9
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

2177:BHR79 RS02205
gene id: 2177:BHR79_RS02205
uniprot id: A0A1L3Q0K6
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS08850
gene id: 2177:BHR79_RS08850
uniprot id: A0A1L3Q457
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS04525
gene id: 2177:BHR79_RS04525
uniprot id: A0A1L3Q1V5
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

2177:BHR79 RS03750
gene id: 2177:BHR79_RS03750
uniprot id: A0A1L3Q1E9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2177:BHR79 RS01000
gene id: 2177:BHR79_RS01000
uniprot id: A0A1L3PZY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

2177:BHR79 RS07430
gene id: 2177:BHR79_RS07430
uniprot id: A0A1L3Q380
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS08015
gene id: 2177:BHR79_RS08015
uniprot id: A0A1L3Q3F7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2177:BHR79 RS05260
gene id: 2177:BHR79_RS05260
uniprot id: A0A1L3Q2C0
names: Similarity
messages: Belongs to the eIF-2-alpha family.

2177:BHR79 RS05110
gene id: 2177:BHR79_RS05110
uniprot id: A0A1L3Q4Z9
names: Similarity
messages: Belongs to the MoaB/Mog family.

2177:BHR79 RS01415
gene id: 2177:BHR79_RS01415
uniprot id: A0A1L3Q070
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2177:BHR79 RS00920
gene id: 2177:BHR79_RS00920
uniprot id: A0A1L3PZY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

2177:BHR79 RS03175
gene id: 2177:BHR79_RS03175
uniprot id: A0A1L3Q130
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS09655
gene id: 2177:BHR79_RS09655
uniprot id: A0A1L3Q495
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS00875
gene id: 2177:BHR79_RS00875
uniprot id: A0A1L3PZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

2177:BHR79 RS04915
gene id: 2177:BHR79_RS04915
uniprot id: A0A1L3Q1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

2177:BHR79 RS00140
gene id: 2177:BHR79_RS00140
uniprot id: A0A1L3PZL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

2177:BHR79 RS09235
gene id: 2177:BHR79_RS09235
uniprot id: A0A1L3Q431
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS02090
gene id: 2177:BHR79_RS02090
uniprot id: A0A1L3Q0J5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS07905
gene id: 2177:BHR79_RS07905
uniprot id: A0A1L3Q3D9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

2177:BHR79 RS01155
gene id: 2177:BHR79_RS01155
uniprot id: A0A1L3Q0D7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

2177:BHR79 RS00975
gene id: 2177:BHR79_RS00975
uniprot id: A0A1L3Q009
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

2177:BHR79 RS01430
gene id: 2177:BHR79_RS01430
uniprot id: A0A1L3Q0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

2177:BHR79 RS06910
gene id: 2177:BHR79_RS06910
uniprot id: A0A1L3Q2Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

2177:BHR79 RS01205
gene id: 2177:BHR79_RS01205
uniprot id: A0A1L3Q0E6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

2177:BHR79 RS09770
gene id: 2177:BHR79_RS09770
uniprot id: A0A1L3Q4C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

2177:BHR79 RS06970
gene id: 2177:BHR79_RS06970
uniprot id: A0A1L3Q303
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

2177:BHR79 RS05280
gene id: 2177:BHR79_RS05280
uniprot id: A0A1L3Q269
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

2177:BHR79 RS08670
gene id: 2177:BHR79_RS08670
uniprot id: A0A1L3Q3V4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

2177:BHR79 RS05100
gene id: 2177:BHR79_RS05100
uniprot id: A0A1L3Q4S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

2177:BHR79 RS02340
gene id: 2177:BHR79_RS02340
uniprot id: A0A1L3Q0R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

2177:BHR79 RS00330
gene id: 2177:BHR79_RS00330
uniprot id: A0A1L3PZM4
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

2177:BHR79 RS08855
gene id: 2177:BHR79_RS08855
uniprot id: A0A1L3Q518
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS00155
gene id: 2177:BHR79_RS00155
uniprot id: A0A1L3PZI9
names: Similarity
messages: Belongs to the TlyA family.

2177:BHR79 RS00985
gene id: 2177:BHR79_RS00985
uniprot id: A0A1L3Q0A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

2177:BHR79 RS09615
gene id: 2177:BHR79_RS09615
uniprot id: A0A1L3Q4C5
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

2177:BHR79 RS02045
gene id: 2177:BHR79_RS02045
uniprot id: A0A1L3Q4M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

2177:BHR79 RS10175
gene id: 2177:BHR79_RS10175
uniprot id: A0A1L3Q566
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

2177:BHR79 RS07405
gene id: 2177:BHR79_RS07405
uniprot id: A0A1L3Q3F8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS07490
gene id: 2177:BHR79_RS07490
uniprot id: A0A1L3Q544
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

2177:BHR79 RS03815
gene id: 2177:BHR79_RS03815
uniprot id: A0A1L3Q1E6
names: Similarity
messages: Belongs to the HisA/HisF family.

2177:BHR79 RS08495
gene id: 2177:BHR79_RS08495
uniprot id: A0A1L3Q3Q1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

2177:BHR79 RS03510
gene id: 2177:BHR79_RS03510
uniprot id: A0A1L3Q188
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

2177:BHR79 RS02135
gene id: 2177:BHR79_RS02135
uniprot id: A0A1L3Q0J8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2177:BHR79 RS01870
gene id: 2177:BHR79_RS01870
uniprot id: A0A1L3Q0E5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

2177:BHR79 RS07955
gene id: 2177:BHR79_RS07955
uniprot id: A0A1L3Q3I6
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS05940
gene id: 2177:BHR79_RS05940
uniprot id: A0A1L3Q2H1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07055
gene id: 2177:BHR79_RS07055
uniprot id: A0A1L3Q343
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2177:BHR79 RS03535
gene id: 2177:BHR79_RS03535
uniprot id: A0A1L3Q193
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

2177:BHR79 RS02445
gene id: 2177:BHR79_RS02445
uniprot id: A0A1L3Q0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

2177:BHR79 RS06250
gene id: 2177:BHR79_RS06250
uniprot id: A0A1L3Q4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

2177:BHR79 RS06810
gene id: 2177:BHR79_RS06810
uniprot id: A0A1L3Q2Y2
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS00275
gene id: 2177:BHR79_RS00275
uniprot id: A0A1L3PZK7
names: Similarity
messages: Belongs to the AAA ATPase family.

2177:BHR79 RS04830
gene id: 2177:BHR79_RS04830
uniprot id: A0A1L3Q1X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS04735
gene id: 2177:BHR79_RS04735
uniprot id: A0A1L3Q1V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

2177:BHR79 RS05360
gene id: 2177:BHR79_RS05360
uniprot id: A0A1L3Q2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

2177:BHR79 RS10195
gene id: 2177:BHR79_RS10195
uniprot id: A0A1L3Q4I4
names: Similarity
messages: Belongs to the UPF0758 family.

2177:BHR79 RS06015
gene id: 2177:BHR79_RS06015
uniprot id: A0A1L3Q2I2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

2177:BHR79 RS02785
gene id: 2177:BHR79_RS02785
uniprot id: A0A1L3Q0Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

2177:BHR79 RS07670
gene id: 2177:BHR79_RS07670
uniprot id: A0A1L3Q3J4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

2177:BHR79 RS06935
gene id: 2177:BHR79_RS06935
uniprot id: A0A1L3Q324
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2177:BHR79 RS02075
gene id: 2177:BHR79_RS02075
uniprot id: A0A1L3Q0J0
names: Similarity
messages: Belongs to the AAA ATPase family.

2177:BHR79 RS01600
gene id: 2177:BHR79_RS01600
uniprot id: A0A1L3Q0A1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

2177:BHR79 RS08220
gene id: 2177:BHR79_RS08220
uniprot id: A0A1L3Q3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

2177:BHR79 RS09700
gene id: 2177:BHR79_RS09700
uniprot id: A0A1L3Q4M7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

2177:BHR79 RS00010
gene id: 2177:BHR79_RS00010
uniprot id: A0A1L3PZJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

2177:BHR79 RS08580
gene id: 2177:BHR79_RS08580
uniprot id: A0A1L3Q3Q9
names: Similarity
messages: Belongs to the peptidase S8 family.

2177:BHR79 RS00670
gene id: 2177:BHR79_RS00670
uniprot id: A0A1L3PZT6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

2177:BHR79 RS00760
gene id: 2177:BHR79_RS00760
uniprot id: A0A1L3PZV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

2177:BHR79 RS08520
gene id: 2177:BHR79_RS08520
uniprot id: A0A1L3Q3P2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

2177:BHR79 RS04025
gene id: 2177:BHR79_RS04025
uniprot id: A0A1L3Q1H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

2177:BHR79 RS02240
gene id: 2177:BHR79_RS02240
uniprot id: A0A1L3Q0L5
names: Similarity
messages: Belongs to the SUI1 family.

2177:BHR79 RS00415
gene id: 2177:BHR79_RS00415
uniprot id: A0A1L3PZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2177:BHR79 RS06955
gene id: 2177:BHR79_RS06955
uniprot id: A0A1L3Q2Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS00785
gene id: 2177:BHR79_RS00785
uniprot id: A0A1L3Q4L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS05920
gene id: 2177:BHR79_RS05920
uniprot id: A0A1L3Q2E8
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS05325
gene id: 2177:BHR79_RS05325
uniprot id: A0A1L3Q252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2177:BHR79 RS04695
gene id: 2177:BHR79_RS04695
uniprot id: A0A1L3Q1U8
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

2177:BHR79 RS04490
gene id: 2177:BHR79_RS04490
uniprot id: A0A1L3Q1R8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

2177:BHR79 RS04895
gene id: 2177:BHR79_RS04895
uniprot id: A0A1L3Q202
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04185
gene id: 2177:BHR79_RS04185
uniprot id: A0A1L3Q1T3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS01760
gene id: 2177:BHR79_RS01760
uniprot id: A0A1L3Q0C6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

2177:BHR79 RS09270
gene id: 2177:BHR79_RS09270
uniprot id: A0A1L3Q435
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

2177:BHR79 RS04095
gene id: 2177:BHR79_RS04095
uniprot id: A0A1L3Q1H9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

2177:BHR79 RS05105
gene id: 2177:BHR79_RS05105
uniprot id: A0A1L3Q224
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

2177:BHR79 RS04435
gene id: 2177:BHR79_RS04435
uniprot id: A0A1L3Q1P5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS08965
gene id: 2177:BHR79_RS08965
uniprot id: A0A1L3Q3X5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

2177:BHR79 RS06950
gene id: 2177:BHR79_RS06950
uniprot id: A0A1H2UCB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

2177:BHR79 RS06545
gene id: 2177:BHR79_RS06545
uniprot id: A0A1L3Q2Y9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

2177:BHR79 RS07595
gene id: 2177:BHR79_RS07595
uniprot id: A0A1L3Q396
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2177:BHR79 RS01030
gene id: 2177:BHR79_RS01030
uniprot id: A0A1L3Q017
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

2177:BHR79 RS06965
gene id: 2177:BHR79_RS06965
uniprot id: A0A1L3Q2Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS02350
gene id: 2177:BHR79_RS02350
uniprot id: A0A1L3Q0R5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07110
gene id: 2177:BHR79_RS07110
uniprot id: A0A1L3Q352
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

2177:BHR79 RS04265
gene id: 2177:BHR79_RS04265
uniprot id: A0A1L3Q1M6
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

2177:BHR79 RS07760
gene id: 2177:BHR79_RS07760
uniprot id: A0A1L3Q3C4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07590
gene id: 2177:BHR79_RS07590
uniprot id: A0A1L3Q394
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

2177:BHR79 RS03880
gene id: 2177:BHR79_RS03880
uniprot id: A0A1L3Q1F5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

2177:BHR79 RS00440
gene id: 2177:BHR79_RS00440
uniprot id: A0A1L3PZR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

2177:BHR79 RS00485
gene id: 2177:BHR79_RS00485
uniprot id: A0A1L3Q016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

2177:BHR79 RS01315
gene id: 2177:BHR79_RS01315
uniprot id: A0A1L3Q051
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

2177:BHR79 RS06405
gene id: 2177:BHR79_RS06405
uniprot id: A0A1L3Q2M9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

2177:BHR79 RS04405
gene id: 2177:BHR79_RS04405
uniprot id: A0A1L3Q1R0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

2177:BHR79 RS06035
gene id: 2177:BHR79_RS06035
uniprot id: A0A1L3Q515
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

2177:BHR79 RS09260
gene id: 2177:BHR79_RS09260
uniprot id: A0A1L3Q438
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2177:BHR79 RS04890
gene id: 2177:BHR79_RS04890
uniprot id: A0A1L3Q1Y5
names: Similarity
messages: Belongs to the UPF0107 family.

2177:BHR79 RS07700
gene id: 2177:BHR79_RS07700
uniprot id: A0A1L3Q5B0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS00745
gene id: 2177:BHR79_RS00745
uniprot id: A0A1L3PZX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2177:BHR79 RS06840
gene id: 2177:BHR79_RS06840
uniprot id: A0A1L3Q2Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

2177:BHR79 RS02805
gene id: 2177:BHR79_RS02805
uniprot id: A0A1L3Q0X3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07990
gene id: 2177:BHR79_RS07990
uniprot id: A0A1L3Q3I9
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04370
gene id: 2177:BHR79_RS04370
uniprot id: A0A1L3Q1N5
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

2177:BHR79 RS02620
gene id: 2177:BHR79_RS02620
uniprot id: A0A1L3Q0T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

2177:BHR79 RS07035
gene id: 2177:BHR79_RS07035
uniprot id: A0A1L3Q395
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03615
gene id: 2177:BHR79_RS03615
uniprot id: A0A1L3Q1I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS08515
gene id: 2177:BHR79_RS08515
uniprot id: A0A1L3Q3Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

2177:BHR79 RS08545
gene id: 2177:BHR79_RS08545
uniprot id: A0A1L3Q3R2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2177:BHR79 RS03585
gene id: 2177:BHR79_RS03585
uniprot id: A0A1L3Q197
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

2177:BHR79 RS01670
gene id: 2177:BHR79_RS01670
uniprot id: A0A1L3Q0B4
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS05600
gene id: 2177:BHR79_RS05600
uniprot id: A0A1L3Q2C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

2177:BHR79 RS10170
gene id: 2177:BHR79_RS10170
uniprot id: A0A1L3Q4I2
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

2177:BHR79 RS02665
gene id: 2177:BHR79_RS02665
uniprot id: A0A1L3Q0U5
names: Similarity
messages: Belongs to the peptidase S49 family.

2177:BHR79 RS02630
gene id: 2177:BHR79_RS02630
uniprot id: A0A1L3Q0U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

2177:BHR79 RS00535
gene id: 2177:BHR79_RS00535
uniprot id: A0A1L3Q027
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2177:BHR79 RS05630
gene id: 2177:BHR79_RS05630
uniprot id: A0A1L3Q2A7
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

2177:BHR79 RS01130
gene id: 2177:BHR79_RS01130
uniprot id: A0A1L3Q006
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2177:BHR79 RS00770
gene id: 2177:BHR79_RS00770
uniprot id: A0A1L3PZU8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

2177:BHR79 RS04835
gene id: 2177:BHR79_RS04835
uniprot id: A0A1L3Q1W8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS07530
gene id: 2177:BHR79_RS07530
uniprot id: A0A1L3Q390
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

2177:BHR79 RS01845
gene id: 2177:BHR79_RS01845
uniprot id: A0A1L3Q0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2177:BHR79 RS05340
gene id: 2177:BHR79_RS05340
uniprot id: A0A1L3Q266
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2177:BHR79 RS08960
gene id: 2177:BHR79_RS08960
uniprot id: A0A1L3Q476
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

2177:BHR79 RS06850
gene id: 2177:BHR79_RS06850
uniprot id: A0A1H2UE90
names: Similarity
messages: Belongs to the UPF0251 family.

2177:BHR79 RS00420
gene id: 2177:BHR79_RS00420
uniprot id: A0A1L3Q008
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS08890
gene id: 2177:BHR79_RS08890
uniprot id: A0A1L3Q3X6
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

2177:BHR79 RS05350
gene id: 2177:BHR79_RS05350
uniprot id: A0A1L3Q264
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

2177:BHR79 RS08775
gene id: 2177:BHR79_RS08775
uniprot id: A0A1L3Q3V8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS09540
gene id: 2177:BHR79_RS09540
uniprot id: A0A1L3Q477
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04840
gene id: 2177:BHR79_RS04840
uniprot id: A0A1L3Q1X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS01610
gene id: 2177:BHR79_RS01610
uniprot id: A0A1L3Q0A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

2177:BHR79 RS01680
gene id: 2177:BHR79_RS01680
uniprot id: A0A1L3Q0C2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

2177:BHR79 RS09950
gene id: 2177:BHR79_RS09950
uniprot id: A0A1L3Q4E7
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS02990
gene id: 2177:BHR79_RS02990
uniprot id: A0A1L3Q4T7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

2177:BHR79 RS09325
gene id: 2177:BHR79_RS09325
uniprot id: A0A1L3Q441
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

2177:BHR79 RS01225
gene id: 2177:BHR79_RS01225
uniprot id: A0A1L3Q060
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

2177:BHR79 RS07520
gene id: 2177:BHR79_RS07520
uniprot id: A0A1L3Q385
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

2177:BHR79 RS04315
gene id: 2177:BHR79_RS04315
uniprot id: A0A1H2VYD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

2177:BHR79 RS00320
gene id: 2177:BHR79_RS00320
uniprot id: A0A1L3PZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

2177:BHR79 RS03235
gene id: 2177:BHR79_RS03235
uniprot id: A0A1L3Q140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS05605
gene id: 2177:BHR79_RS05605
uniprot id: A0A1L3Q558
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

2177:BHR79 RS00845
gene id: 2177:BHR79_RS00845
uniprot id: A0A1L3PZV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

2177:BHR79 RS00835
gene id: 2177:BHR79_RS00835
uniprot id: A0A1L3PZX9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

2177:BHR79 RS07140
gene id: 2177:BHR79_RS07140
uniprot id: A0A1L3Q323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS07400
gene id: 2177:BHR79_RS07400
uniprot id: A0A1L3Q382
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS02210
gene id: 2177:BHR79_RS02210
uniprot id: A0A1L3Q0U4
names: Similarity
messages: Belongs to the DtxR/MntR family.

2177:BHR79 RS00345
gene id: 2177:BHR79_RS00345
uniprot id: A0A1L3PZM7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS09445
gene id: 2177:BHR79_RS09445
uniprot id: A0A1H2SVG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

2177:BHR79 RS00125
gene id: 2177:BHR79_RS00125
uniprot id: A0A1L3PZI7
names: Similarity
messages: Belongs to the UPF0212 family.

2177:BHR79 RS01595
gene id: 2177:BHR79_RS01595
uniprot id: A0A1L3Q0K9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

2177:BHR79 RS07390
gene id: 2177:BHR79_RS07390
uniprot id: A0A1L3Q362
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2177:BHR79 RS07480
gene id: 2177:BHR79_RS07480
uniprot id: A0A1L3Q361
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

2177:BHR79 RS07015
gene id: 2177:BHR79_RS07015
uniprot id: A0A1L3Q300
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS01725
gene id: 2177:BHR79_RS01725
uniprot id: A0A1H2Q817
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

2177:BHR79 RS01520
gene id: 2177:BHR79_RS01520
uniprot id: A0A1L3Q093
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

2177:BHR79 RS01650
gene id: 2177:BHR79_RS01650
uniprot id: A0A1L3Q0A6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07370
gene id: 2177:BHR79_RS07370
uniprot id: A0A1L3Q369
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2177:BHR79 RS03220
gene id: 2177:BHR79_RS03220
uniprot id: A0A1L3Q133
names: Similarity
messages: Belongs to the HepT RNase toxin family.

2177:BHR79 RS07560
gene id: 2177:BHR79_RS07560
uniprot id: A0A1L3Q3B6
names: Similarity
messages: Belongs to the PDCD5 family.

2177:BHR79 RS02735
gene id: 2177:BHR79_RS02735
uniprot id: A0A1L3Q0X6
names: Similarity
messages: Belongs to the TPP enzyme family.

2177:BHR79 RS09935
gene id: 2177:BHR79_RS09935
uniprot id: A0A1L3Q4H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2177:BHR79 RS00315
gene id: 2177:BHR79_RS00315
uniprot id: A0A1L3PZM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

2177:BHR79 RS10340
gene id: 2177:BHR79_RS10340
uniprot id: A0A1L3Q4P1
names: Subcellular Location Annotation
messages: Cell membrane

2177:BHR79 RS04220
gene id: 2177:BHR79_RS04220
uniprot id: A0A1L3Q1K6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

2177:BHR79 RS00805
gene id: 2177:BHR79_RS00805
uniprot id: A0A1L3PZV2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

2177:BHR79 RS07600
gene id: 2177:BHR79_RS07600
uniprot id: A0A1L3Q3A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

2177:BHR79 RS07020
gene id: 2177:BHR79_RS07020
uniprot id: A0A1L3Q305
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS06320
gene id: 2177:BHR79_RS06320
uniprot id: A0A1L3Q2R5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

2177:BHR79 RS10260
gene id: 2177:BHR79_RS10260
uniprot id: A0A1L3Q4W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS01790
gene id: 2177:BHR79_RS01790
uniprot id: A0A1L3Q0E0
names: Similarity
messages: Belongs to the UPF0200 family.

2177:BHR79 RS07555
gene id: 2177:BHR79_RS07555
uniprot id: A0A1L3Q371
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS06295
gene id: 2177:BHR79_RS06295
uniprot id: A0A1L3Q2M1
names: Subcellular Location Annotation
messages: Cell membrane

2177:BHR79 RS08940
gene id: 2177:BHR79_RS08940
uniprot id: A0A1L3Q3Y4
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS08255
gene id: 2177:BHR79_RS08255
uniprot id: A0A1L3Q3L8
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS02290
gene id: 2177:BHR79_RS02290
uniprot id: A0A1L3Q0M4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

2177:BHR79 RS04115
gene id: 2177:BHR79_RS04115
uniprot id: A0A1L3Q4R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

2177:BHR79 RS04080
gene id: 2177:BHR79_RS04080
uniprot id: A0A1L3Q1L9
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS07550
gene id: 2177:BHR79_RS07550
uniprot id: A0A1L3Q503
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2177:BHR79 RS06065
gene id: 2177:BHR79_RS06065
uniprot id: A0A1L3Q2H4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2177:BHR79 RS06080
gene id: 2177:BHR79_RS06080
uniprot id: A0A1L3Q2K3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS09645
gene id: 2177:BHR79_RS09645
uniprot id: A0A1H2SXE2
names: Function
messages: Probably involved in the biogenesis of the ribosome.

2177:BHR79 RS06665
gene id: 2177:BHR79_RS06665
uniprot id: A0A1L3Q2X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

2177:BHR79 RS06795
gene id: 2177:BHR79_RS06795
uniprot id: A0A1H2UHH6
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

2177:BHR79 RS09910
gene id: 2177:BHR79_RS09910
uniprot id: A0A1L3Q4J8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

2177:BHR79 RS02260
gene id: 2177:BHR79_RS02260
uniprot id: A0A1L3Q0L6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

2177:BHR79 RS04110
gene id: 2177:BHR79_RS04110
uniprot id: A0A1L3Q1J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

2177:BHR79 RS07625
gene id: 2177:BHR79_RS07625
uniprot id: A0A1L3Q389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

2177:BHR79 RS07645
gene id: 2177:BHR79_RS07645
uniprot id: A0A1L3Q3A6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

2177:BHR79 RS08930
gene id: 2177:BHR79_RS08930
uniprot id: A0A1L3Q3Z1
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS03355
gene id: 2177:BHR79_RS03355
uniprot id: A0A1L3Q176
names: Similarity
messages: Belongs to the peptidase M24B family.

2177:BHR79 RS07775
gene id: 2177:BHR79_RS07775
uniprot id: A0A1L3Q3E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

2177:BHR79 RS03795
gene id: 2177:BHR79_RS03795
uniprot id: A0A1L3Q1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

2177:BHR79 RS06070
gene id: 2177:BHR79_RS06070
uniprot id: A0A1L3Q2J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS06555
gene id: 2177:BHR79_RS06555
uniprot id: A0A1L3Q2V2
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

2177:BHR79 RS01485
gene id: 2177:BHR79_RS01485
uniprot id: A0A1L3Q079
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2177:BHR79 RS03890
gene id: 2177:BHR79_RS03890
uniprot id: A0A1L3Q1N6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

2177:BHR79 RS05335
gene id: 2177:BHR79_RS05335
uniprot id: A0A1L3Q250
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2177:BHR79 RS02585
gene id: 2177:BHR79_RS02585
uniprot id: A0A1L3Q0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

2177:BHR79 RS00610
gene id: 2177:BHR79_RS00610
uniprot id: A0A1L3PZU9
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

2177:BHR79 RS01525
gene id: 2177:BHR79_RS01525
uniprot id: A0A1L3Q077
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

2177:BHR79 RS06210
gene id: 2177:BHR79_RS06210
uniprot id: A0A1L3Q2J5
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2177:BHR79 RS05835
gene id: 2177:BHR79_RS05835
uniprot id: A0A1L3Q2G3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06415
gene id: 2177:BHR79_RS06415
uniprot id: A0A1L3Q2P1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

2177:BHR79 RS05710
gene id: 2177:BHR79_RS05710
uniprot id: A0A1L3Q2E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

2177:BHR79 RS00585
gene id: 2177:BHR79_RS00585
uniprot id: A0A1L3Q037
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

2177:BHR79 RS04655
gene id: 2177:BHR79_RS04655
uniprot id: A0A1L3Q1T7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS00825
gene id: 2177:BHR79_RS00825
uniprot id: A0A1L3Q075
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

2177:BHR79 RS09750
gene id: 2177:BHR79_RS09750
uniprot id: A0A1L3Q584
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS07305
gene id: 2177:BHR79_RS07305
uniprot id: A0A1L3Q330
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

2177:BHR79 RS07345
gene id: 2177:BHR79_RS07345
uniprot id: A0A1L3Q374
names: Similarity
messages: Belongs to the UPF0280 family.

2177:BHR79 RS00145
gene id: 2177:BHR79_RS00145
uniprot id: A0A1L3PZJ5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

2177:BHR79 RS09665
gene id: 2177:BHR79_RS09665
uniprot id: A0A1L3Q496
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

2177:BHR79 RS00470
gene id: 2177:BHR79_RS00470
uniprot id: A0A1L3PZQ1
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

2177:BHR79 RS08150
gene id: 2177:BHR79_RS08150
uniprot id: A0A1L3Q3J8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

2177:BHR79 RS05420
gene id: 2177:BHR79_RS05420
uniprot id: A0A1L3Q268
names: Function
messages: Part of a potassium transport system.

2177:BHR79 RS07230
gene id: 2177:BHR79_RS07230
uniprot id: A0A1L3Q353
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

2177:BHR79 RS00750
gene id: 2177:BHR79_RS00750
uniprot id: A0A1L3PZU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

2177:BHR79 RS08295
gene id: 2177:BHR79_RS08295
uniprot id: A0A1L3Q5B7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2177:BHR79 RS06990
gene id: 2177:BHR79_RS06990
uniprot id: A0A1L3Q2Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2177:BHR79 RS04230
gene id: 2177:BHR79_RS04230
uniprot id: A0A1L3Q1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

2177:BHR79 RS10090
gene id: 2177:BHR79_RS10090
uniprot id: A0A1L3Q4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

2177:BHR79 RS05930
gene id: 2177:BHR79_RS05930
uniprot id: A0A1L3Q2F4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

2177:BHR79 RS06680
gene id: 2177:BHR79_RS06680
uniprot id: A0A1L3Q2T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

2177:BHR79 RS05560
gene id: 2177:BHR79_RS05560
uniprot id: A0A1L3Q295
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

2177:BHR79 RS01470
gene id: 2177:BHR79_RS01470
uniprot id: A0A1L3Q067
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

2177:BHR79 RS05485
gene id: 2177:BHR79_RS05485
uniprot id: A0A1L3Q4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

2177:BHR79 RS01940
gene id: 2177:BHR79_RS01940
uniprot id: A0A1L3Q0G1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

2177:BHR79 RS05810
gene id: 2177:BHR79_RS05810
uniprot id: A0A1L3Q4U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

2177:BHR79 RS02230
gene id: 2177:BHR79_RS02230
uniprot id: A0A1L3Q0P2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

2177:BHR79 RS02530
gene id: 2177:BHR79_RS02530
uniprot id: A0A1L3Q0R0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2177:BHR79 RS06185
gene id: 2177:BHR79_RS06185
uniprot id: A0A1L3Q2M8
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

2177:BHR79 RS10345
gene id: 2177:BHR79_RS10345
uniprot id: A0A1L3Q4L5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

2177:BHR79 RS09680
gene id: 2177:BHR79_RS09680
uniprot id: A0A1L3Q497
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

2177:BHR79 RS08035
gene id: 2177:BHR79_RS08035
uniprot id: A0A1L3Q3H9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

2177:BHR79 RS05165
gene id: 2177:BHR79_RS05165
uniprot id: A0A1L3Q238
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS04135
gene id: 2177:BHR79_RS04135
uniprot id: A0A1L3Q1N1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS05085
gene id: 2177:BHR79_RS05085
uniprot id: A0A1L3Q214
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2177:BHR79 RS07800
gene id: 2177:BHR79_RS07800
uniprot id: A0A1L3Q3E3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS02255
gene id: 2177:BHR79_RS02255
uniprot id: A0A1H2QIK9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

2177:BHR79 RS03070
gene id: 2177:BHR79_RS03070
uniprot id: A0A1L3Q189
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS07245
gene id: 2177:BHR79_RS07245
uniprot id: A0A1L3Q373
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

2177:BHR79 RS05945
gene id: 2177:BHR79_RS05945
uniprot id: A0A1L3Q2I3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

2177:BHR79 RS03965
gene id: 2177:BHR79_RS03965
uniprot id: A0A1L3Q1G0
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

2177:BHR79 RS07795
gene id: 2177:BHR79_RS07795
uniprot id: A0A1L3Q3B8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

2177:BHR79 RS05610
gene id: 2177:BHR79_RS05610
uniprot id: A0A1L3Q299
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

2177:BHR79 RS00120
gene id: 2177:BHR79_RS00120
uniprot id: A0A1L3PZL5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

2177:BHR79 RS04410
gene id: 2177:BHR79_RS04410
uniprot id: A0A1L3Q1X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

2177:BHR79 RS04280
gene id: 2177:BHR79_RS04280
uniprot id: A0A1L3Q1P2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS02085
gene id: 2177:BHR79_RS02085
uniprot id: A0A1L3Q4U9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

2177:BHR79 RS07935
gene id: 2177:BHR79_RS07935
uniprot id: A0A1L3Q554
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

2177:BHR79 RS03825
gene id: 2177:BHR79_RS03825
uniprot id: A0A1L3Q1E4
names: Similarity
messages: Belongs to the thymidylate kinase family.

2177:BHR79 RS02835
gene id: 2177:BHR79_RS02835
uniprot id: A0A1L3Q0X4
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS10060
gene id: 2177:BHR79_RS10060
uniprot id: A0A1L3Q4J9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS06235
gene id: 2177:BHR79_RS06235
uniprot id: A0A1L3Q2M2
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

2177:BHR79 RS06090
gene id: 2177:BHR79_RS06090
uniprot id: A0A1L3Q2H8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2177:BHR79 RS05330
gene id: 2177:BHR79_RS05330
uniprot id: A0A1L3Q280
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2177:BHR79 RS04800
gene id: 2177:BHR79_RS04800
uniprot id: A0A1L3Q1W0
names: Similarity
messages: Belongs to the HdrC family.

2177:BHR79 RS02625
gene id: 2177:BHR79_RS02625
uniprot id: A0A1L3Q0V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

2177:BHR79 RS07425
gene id: 2177:BHR79_RS07425
uniprot id: A0A1L3Q355
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2177:BHR79 RS02250
gene id: 2177:BHR79_RS02250
uniprot id: A0A1L3Q0N0
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

2177:BHR79 RS06240
gene id: 2177:BHR79_RS06240
uniprot id: A0A1L3Q2N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

2177:BHR79 RS03610
gene id: 2177:BHR79_RS03610
uniprot id: A0A1L3Q1C1
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04205
gene id: 2177:BHR79_RS04205
uniprot id: A0A1L3Q1M3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS02020
gene id: 2177:BHR79_RS02020
uniprot id: A0A1L3Q504
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

2177:BHR79 RS03565
gene id: 2177:BHR79_RS03565
uniprot id: A0A1L3Q198
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

2177:BHR79 RS00660
gene id: 2177:BHR79_RS00660
uniprot id: A0A1L3PZV9
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

2177:BHR79 RS00600
gene id: 2177:BHR79_RS00600
uniprot id: A0A1L3PZR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

2177:BHR79 RS03980
gene id: 2177:BHR79_RS03980
uniprot id: A0A3M9L4Q4
names: Caution
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS03250
gene id: 2177:BHR79_RS03250
uniprot id: A0A1L3Q134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS01060
gene id: 2177:BHR79_RS01060
uniprot id: A0A1L3Q000
names: Similarity
messages: Belongs to the malic enzymes family.

2177:BHR79 RS02890
gene id: 2177:BHR79_RS02890
uniprot id: A0A1L3Q4N9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

2177:BHR79 RS00170
gene id: 2177:BHR79_RS00170
uniprot id: A0A1L3PZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

2177:BHR79 RS06870
gene id: 2177:BHR79_RS06870
uniprot id: A0A1L3Q2Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

2177:BHR79 RS05295
gene id: 2177:BHR79_RS05295
uniprot id: A0A1L3Q249
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

2177:BHR79 RS05750
gene id: 2177:BHR79_RS05750
uniprot id: A0A1L3Q2D0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

2177:BHR79 RS06055
gene id: 2177:BHR79_RS06055
uniprot id: A0A1L3Q2G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS04690
gene id: 2177:BHR79_RS04690
uniprot id: A0A1L3Q1Y1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

2177:BHR79 RS06985
gene id: 2177:BHR79_RS06985
uniprot id: A0A1L3Q378
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS09375
gene id: 2177:BHR79_RS09375
uniprot id: A0A1L3Q4A3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2177:BHR79 RS01570
gene id: 2177:BHR79_RS01570
uniprot id: A0A1L3Q0A2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

2177:BHR79 RS09670
gene id: 2177:BHR79_RS09670
uniprot id: A0A1L3Q4D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

2177:BHR79 RS02690
gene id: 2177:BHR79_RS02690
uniprot id: A0A1L3Q0V0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

2177:BHR79 RS08500
gene id: 2177:BHR79_RS08500
uniprot id: A0A1L3Q3Q4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

2177:BHR79 RS02345
gene id: 2177:BHR79_RS02345
uniprot id: A0A1L3Q0M9
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

2177:BHR79 RS01605
gene id: 2177:BHR79_RS01605
uniprot id: A0A1L3Q0B8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

2177:BHR79 RS03390
gene id: 2177:BHR79_RS03390
uniprot id: A0A1L3Q168
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS09130
gene id: 2177:BHR79_RS09130
uniprot id: A0A1L3Q421
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS01145
gene id: 2177:BHR79_RS01145
uniprot id: A0A1L3Q020
names: Similarity
messages: Belongs to the HsdR family.

2177:BHR79 RS07785
gene id: 2177:BHR79_RS07785
uniprot id: A0A1L3Q3B2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

2177:BHR79 RS00865
gene id: 2177:BHR79_RS00865
uniprot id: A0A1L3PZX4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS08010
gene id: 2177:BHR79_RS08010
uniprot id: A0A1L3Q532
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

2177:BHR79 RS00895
gene id: 2177:BHR79_RS00895
uniprot id: A0A1L3PZW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

2177:BHR79 RS06765
gene id: 2177:BHR79_RS06765
uniprot id: A0A1L3Q2U7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

2177:BHR79 RS03415
gene id: 2177:BHR79_RS03415
uniprot id: A0A1L3Q4R2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

2177:BHR79 RS09710
gene id: 2177:BHR79_RS09710
uniprot id: A0A1L3Q5D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS06770
gene id: 2177:BHR79_RS06770
uniprot id: A0A1L3Q2Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

2177:BHR79 RS09890
gene id: 2177:BHR79_RS09890
uniprot id: A0A1L3Q4D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS10255
gene id: 2177:BHR79_RS10255
uniprot id: A0A1L3Q4J5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS03875
gene id: 2177:BHR79_RS03875
uniprot id: A0A1L3Q1E5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

2177:BHR79 RS09265
gene id: 2177:BHR79_RS09265
uniprot id: A0A1L3Q480
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS04020
gene id: 2177:BHR79_RS04020
uniprot id: A0A1L3Q1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

2177:BHR79 RS07680
gene id: 2177:BHR79_RS07680
uniprot id: A0A1L3Q3D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS09660
gene id: 2177:BHR79_RS09660
uniprot id: A0A1L3Q4F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

2177:BHR79 RS01590
gene id: 2177:BHR79_RS01590
uniprot id: A0A1L3Q096
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

2177:BHR79 RS08505
gene id: 2177:BHR79_RS08505
uniprot id: A0A1L3Q3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

2177:BHR79 RS08435
gene id: 2177:BHR79_RS08435
uniprot id: A0A1L3Q3P7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

2177:BHR79 RS06115
gene id: 2177:BHR79_RS06115
uniprot id: A0A1L3Q2J7
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

2177:BHR79 RS10285
gene id: 2177:BHR79_RS10285
uniprot id: A0A1L3Q4K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

2177:BHR79 RS05465
gene id: 2177:BHR79_RS05465
uniprot id: A0A1L3Q2G2
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04820
gene id: 2177:BHR79_RS04820
uniprot id: A0A1L3Q1X8
names: Similarity
messages: Belongs to the MtrH family.

2177:BHR79 RS06275
gene id: 2177:BHR79_RS06275
uniprot id: A0A1L3Q2K7
names: Similarity
messages: Belongs to the TrpF family.

2177:BHR79 RS04545
gene id: 2177:BHR79_RS04545
uniprot id: A0A1L3Q1R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS10320
gene id: 2177:BHR79_RS10320
uniprot id: A0A1L3Q4X4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

2177:BHR79 RS00030
gene id: 2177:BHR79_RS00030
uniprot id: A0A1L3PZJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

2177:BHR79 RS07235
gene id: 2177:BHR79_RS07235
uniprot id: A0A1L3Q3B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

2177:BHR79 RS07005
gene id: 2177:BHR79_RS07005
uniprot id: A0A1L3Q313
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2177:BHR79 RS09995
gene id: 2177:BHR79_RS09995
uniprot id: A0A3M9L8V0
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS00035
gene id: 2177:BHR79_RS00035
uniprot id: A0A1L3PZH5
names: Similarity
messages: Belongs to the UPF0145 family.

2177:BHR79 RS02405
gene id: 2177:BHR79_RS02405
uniprot id: A0A1L3Q4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

2177:BHR79 RS00305
gene id: 2177:BHR79_RS00305
uniprot id: A0A1L3PZM1
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

2177:BHR79 RS06360
gene id: 2177:BHR79_RS06360
uniprot id: A0A1L3Q2Q5
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

2177:BHR79 RS05270
gene id: 2177:BHR79_RS05270
uniprot id: A0A1L3Q283
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS06960
gene id: 2177:BHR79_RS06960
uniprot id: A0A1L3Q2Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

2177:BHR79 RS00765
gene id: 2177:BHR79_RS00765
uniprot id: A0A1L3PZW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

2177:BHR79 RS00680
gene id: 2177:BHR79_RS00680
uniprot id: A0A1L3PZW0
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

2177:BHR79 RS00540
gene id: 2177:BHR79_RS00540
uniprot id: A0A1L3PZR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

2177:BHR79 RS04825
gene id: 2177:BHR79_RS04825
uniprot id: A0A1L3Q1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

2177:BHR79 RS07130
gene id: 2177:BHR79_RS07130
uniprot id: A0A1L3Q318
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2177:BHR79 RS07845
gene id: 2177:BHR79_RS07845
uniprot id: A0A1L3Q3F3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

2177:BHR79 RS07285
gene id: 2177:BHR79_RS07285
uniprot id: A0A1L3Q4Y6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS03885
gene id: 2177:BHR79_RS03885
uniprot id: A0A1L3Q1H2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

2177:BHR79 RS01280
gene id: 2177:BHR79_RS01280
uniprot id: A0A1L3Q040
names: Similarity
messages: Belongs to the AAA ATPase family.

2177:BHR79 RS06085
gene id: 2177:BHR79_RS06085
uniprot id: A0A1L3Q2Q7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2177:BHR79 RS06995
gene id: 2177:BHR79_RS06995
uniprot id: A0A1L3Q333
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

2177:BHR79 RS09880
gene id: 2177:BHR79_RS09880
uniprot id: A0A1L3Q4C7
names: Similarity
messages: Belongs to the IMPACT family.

2177:BHR79 RS10205
gene id: 2177:BHR79_RS10205
uniprot id: A0A1L3Q4H2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

2177:BHR79 RS06925
gene id: 2177:BHR79_RS06925
uniprot id: A0A1L3Q368
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2177:BHR79 RS04930
gene id: 2177:BHR79_RS04930
uniprot id: A0A1L3Q1Z3
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

2177:BHR79 RS09360
gene id: 2177:BHR79_RS09360
uniprot id: A0A1L3Q449
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

2177:BHR79 RS03745
gene id: 2177:BHR79_RS03745
uniprot id: A0A1L3Q1C9
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS02570
gene id: 2177:BHR79_RS02570
uniprot id: A0A1L3Q0S4
names: Similarity
messages: Belongs to the AAA ATPase family.

2177:BHR79 RS03790
gene id: 2177:BHR79_RS03790
uniprot id: A0A1L3Q1H0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

2177:BHR79 RS08040
gene id: 2177:BHR79_RS08040
uniprot id: A0A1L3Q3I0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2177:BHR79 RS05655
gene id: 2177:BHR79_RS05655
uniprot id: A0A1L3Q2A5
names: Similarity
messages: Belongs to the acylphosphatase family.

2177:BHR79 RS09790
gene id: 2177:BHR79_RS09790
uniprot id: A0A1L3Q4H1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

2177:BHR79 RS09685
gene id: 2177:BHR79_RS09685
uniprot id: A0A1L3Q4D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

2177:BHR79 RS09635
gene id: 2177:BHR79_RS09635
uniprot id: A0A1L3Q494
names: Similarity
messages: Belongs to the LarC family.

2177:BHR79 RS00740
gene id: 2177:BHR79_RS00740
uniprot id: A0A1L3PZV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS06940
gene id: 2177:BHR79_RS06940
uniprot id: A0A1L3Q2X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

2177:BHR79 RS01505
gene id: 2177:BHR79_RS01505
uniprot id: A0A1L3Q084
names: Similarity
messages: Belongs to the MtrH family.

2177:BHR79 RS06465
gene id: 2177:BHR79_RS06465
uniprot id: A0A1L3Q2R0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

2177:BHR79 RS01795
gene id: 2177:BHR79_RS01795
uniprot id: A0A1L3Q0D4
names: Similarity
messages: Belongs to the UPF0201 family.

2177:BHR79 RS05740
gene id: 2177:BHR79_RS05740
uniprot id: A0A1L3Q2F2
names: Similarity
messages: Belongs to the CutA family.

2177:BHR79 RS04285
gene id: 2177:BHR79_RS04285
uniprot id: A0A1L3Q4S5
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS07535
gene id: 2177:BHR79_RS07535
uniprot id: A0A1L3Q3A5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

2177:BHR79 RS08725
gene id: 2177:BHR79_RS08725
uniprot id: A0A1L3Q3U8
names: Similarity
messages: Belongs to the UPF0237 family.

2177:BHR79 RS03785
gene id: 2177:BHR79_RS03785
uniprot id: A0A1L3Q1D4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

2177:BHR79 RS09605
gene id: 2177:BHR79_RS09605
uniprot id: A0A1L3Q4E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

2177:BHR79 RS08060
gene id: 2177:BHR79_RS08060
uniprot id: A0A3M9L335
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

2177:BHR79 RS00780
gene id: 2177:BHR79_RS00780
uniprot id: A0A1L3Q4Q7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS05650
gene id: 2177:BHR79_RS05650
uniprot id: A0A1L3Q2J0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS00615
gene id: 2177:BHR79_RS00615
uniprot id: A0A1L3PZS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

2177:BHR79 RS06410
gene id: 2177:BHR79_RS06410
uniprot id: A0A1L3Q2P6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

2177:BHR79 RS09955
gene id: 2177:BHR79_RS09955
uniprot id: A0A1L3Q4R8
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06915
gene id: 2177:BHR79_RS06915
uniprot id: A0A1L3Q2Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2177:BHR79 RS09460
gene id: 2177:BHR79_RS09460
uniprot id: A0A1L3Q464
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2177:BHR79 RS06420
gene id: 2177:BHR79_RS06420
uniprot id: A0A1L3Q2Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

2177:BHR79 RS08845
gene id: 2177:BHR79_RS08845
uniprot id: A0A1L3Q3Y3
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS07825
gene id: 2177:BHR79_RS07825
uniprot id: A0A1L3Q3M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

2177:BHR79 RS09715
gene id: 2177:BHR79_RS09715
uniprot id: A0A1L3Q4G1
names: Similarity
messages: Belongs to the ZPR1 family.

2177:BHR79 RS03620
gene id: 2177:BHR79_RS03620
uniprot id: A0A1L3Q1A8
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06535
gene id: 2177:BHR79_RS06535
uniprot id: A0A1L3Q2S1
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2177:BHR79 RS07720
gene id: 2177:BHR79_RS07720
uniprot id: A0A1L3Q3C0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

2177:BHR79 RS02520
gene id: 2177:BHR79_RS02520
uniprot id: A0A1L3Q0T6
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04795
gene id: 2177:BHR79_RS04795
uniprot id: A0A1L3Q240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

2177:BHR79 RS05045
gene id: 2177:BHR79_RS05045
uniprot id: A0A1L3Q209
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS05895
gene id: 2177:BHR79_RS05895
uniprot id: A0A1L3Q2E7
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

2177:BHR79 RS09875
gene id: 2177:BHR79_RS09875
uniprot id: A0A1L3Q4C9
names: Subcellular Location Annotation
messages: Cell membrane

2177:BHR79 RS07380
gene id: 2177:BHR79_RS07380
uniprot id: A0A1L3Q357
names: Similarity
messages: Belongs to the peptidase C56 family.

2177:BHR79 RS05500
gene id: 2177:BHR79_RS05500
uniprot id: A0A1L3Q279
names: Similarity
messages: Belongs to the FBPase class 2 family.

2177:BHR79 RS03515
gene id: 2177:BHR79_RS03515
uniprot id: A0A1L3Q1A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

2177:BHR79 RS05755
gene id: 2177:BHR79_RS05755
uniprot id: A0A1L3Q2C6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

2177:BHR79 RS08030
gene id: 2177:BHR79_RS08030
uniprot id: A0A1L3Q3H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

2177:BHR79 RS00775
gene id: 2177:BHR79_RS00775
uniprot id: A0A1L3PZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

2177:BHR79 RS03655
gene id: 2177:BHR79_RS03655
uniprot id: A0A1L3Q1B0
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS09530
gene id: 2177:BHR79_RS09530
uniprot id: A0A1L3Q481
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS00300
gene id: 2177:BHR79_RS00300
uniprot id: A0A1L3PZZ1
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

2177:BHR79 RS07195
gene id: 2177:BHR79_RS07195
uniprot id: A0A1L3Q317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

2177:BHR79 RS04495
gene id: 2177:BHR79_RS04495
uniprot id: A0A1L3Q1Q4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

2177:BHR79 RS02270
gene id: 2177:BHR79_RS02270
uniprot id: A0A1L3Q0M7
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS06525
gene id: 2177:BHR79_RS06525
uniprot id: A0A1L3Q2S0
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2177:BHR79 RS07040
gene id: 2177:BHR79_RS07040
uniprot id: A0A1L3Q2Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

2177:BHR79 RS07205
gene id: 2177:BHR79_RS07205
uniprot id: A0A1L3Q328
names: Similarity
messages: Belongs to the class-I fumarase family.

2177:BHR79 RS06500
gene id: 2177:BHR79_RS06500
uniprot id: A0A1L3Q2P8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

2177:BHR79 RS01915
gene id: 2177:BHR79_RS01915
uniprot id: A0A1L3Q0F3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2177:BHR79 RS01055
gene id: 2177:BHR79_RS01055
uniprot id: A0A1L3Q021
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2177:BHR79 RS05475
gene id: 2177:BHR79_RS05475
uniprot id: A0A1L3Q278
names: Subcellular Location Annotation
messages: Membrane

2177:BHR79 RS04275
gene id: 2177:BHR79_RS04275
uniprot id: A0A1L3Q1M1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

2177:BHR79 RS06460
gene id: 2177:BHR79_RS06460
uniprot id: A0A1L3Q2N9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

2177:BHR79 RS08920
gene id: 2177:BHR79_RS08920
uniprot id: A0A1L3Q408
names: Subcellular Location Annotation
messages: Cell membrane

2177:BHR79 RS08975
gene id: 2177:BHR79_RS08975
uniprot id: A0A1L3Q5C7
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

2177:BHR79 RS09060
gene id: 2177:BHR79_RS09060
uniprot id: A0A1L3Q404
names: Similarity
messages: Belongs to the pyruvate kinase family.

2177:BHR79 RS00355
gene id: 2177:BHR79_RS00355
uniprot id: A0A1L3PZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

2177:BHR79 RS05680
gene id: 2177:BHR79_RS05680
uniprot id: A0A1L3Q2E3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

2177:BHR79 RS09320
gene id: 2177:BHR79_RS09320
uniprot id: A0A1L3Q491
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

2177:BHR79 RS08225
gene id: 2177:BHR79_RS08225
uniprot id: A0A1L3Q3J0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm