216938:SHELI RS03945
gene id: 216938:SHELI_RS03945
uniprot id: A0A1B3SLB2
names: Similarity
messages: Belongs to the asp23 family.

216938:SHELI RS05290
gene id: 216938:SHELI_RS05290
uniprot id: A0A1B3SM26
names: Subcellular Location Annotation
messages: Cytoplasm

216938:SHELI RS00850
gene id: 216938:SHELI_RS00850
uniprot id: A0A1B3SJK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

216938:SHELI RS00815
gene id: 216938:SHELI_RS00815
uniprot id: A0A1B3SJK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00925
gene id: 216938:SHELI_RS00925
uniprot id: A0A1B3SJL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS04970
gene id: 216938:SHELI_RS04970
uniprot id: A0A1B3SLY7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216938:SHELI RS01460
gene id: 216938:SHELI_RS01460
uniprot id: A0A1B3SJY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216938:SHELI RS05760
gene id: 216938:SHELI_RS05760
uniprot id: A0A1B3SMD9
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

216938:SHELI RS02060
gene id: 216938:SHELI_RS02060
uniprot id: A0A1B3SK94
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00010
gene id: 216938:SHELI_RS00010
uniprot id: A0A1B3SJ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

216938:SHELI RS04415
gene id: 216938:SHELI_RS04415
uniprot id: A0A1B3SLJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

216938:SHELI RS02895
gene id: 216938:SHELI_RS02895
uniprot id: A0A1B3SKP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

216938:SHELI RS01105
gene id: 216938:SHELI_RS01105
uniprot id: A0A1B3SJQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS04715
gene id: 216938:SHELI_RS04715
uniprot id: A0A1B3SLR0
names: Similarity
messages: Belongs to the thymidylate kinase family.

216938:SHELI RS03700
gene id: 216938:SHELI_RS03700
uniprot id: A0A1B3SL77
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216938:SHELI RS05615
gene id: 216938:SHELI_RS05615
uniprot id: A0A1B3SMB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

216938:SHELI RS04580
gene id: 216938:SHELI_RS04580
uniprot id: A0A1B3SLN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS05565
gene id: 216938:SHELI_RS05565
uniprot id: A0A1B3SMA2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

216938:SHELI RS01490
gene id: 216938:SHELI_RS01490
uniprot id: A0A1B3SJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

216938:SHELI RS05710
gene id: 216938:SHELI_RS05710
uniprot id: A0A1B3SMD0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

216938:SHELI RS01475
gene id: 216938:SHELI_RS01475
uniprot id: A0A1B3SJX5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216938:SHELI RS00460
gene id: 216938:SHELI_RS00460
uniprot id: A0A1B3SJF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS04480
gene id: 216938:SHELI_RS04480
uniprot id: A0A1B3SLL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

216938:SHELI RS05835
gene id: 216938:SHELI_RS05835
uniprot id: A0A1B3SME2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

216938:SHELI RS01120
gene id: 216938:SHELI_RS01120
uniprot id: A0A1B3SJR2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

216938:SHELI RS03435
gene id: 216938:SHELI_RS03435
uniprot id: A0A1B3SL23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

216938:SHELI RS01485
gene id: 216938:SHELI_RS01485
uniprot id: A0A1B3SJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

216938:SHELI RS00320
gene id: 216938:SHELI_RS00320
uniprot id: A0A1B3SJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

216938:SHELI RS00600
gene id: 216938:SHELI_RS00600
uniprot id: A0A1B3SJF8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

216938:SHELI RS05525
gene id: 216938:SHELI_RS05525
uniprot id: A0A1B3SM74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

216938:SHELI RS01675
gene id: 216938:SHELI_RS01675
uniprot id: A0A1B3SK15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

216938:SHELI RS04435
gene id: 216938:SHELI_RS04435
uniprot id: A0A1B3SLL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

216938:SHELI RS01705
gene id: 216938:SHELI_RS01705
uniprot id: A0A1B3SK28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

216938:SHELI RS04760
gene id: 216938:SHELI_RS04760
uniprot id: A0A1B3SLT3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216938:SHELI RS05515
gene id: 216938:SHELI_RS05515
uniprot id: A0A1B3SM91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

216938:SHELI RS04405
gene id: 216938:SHELI_RS04405
uniprot id: A0A1B3SLK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

216938:SHELI RS04000
gene id: 216938:SHELI_RS04000
uniprot id: A0A1B3SLC0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

216938:SHELI RS04470
gene id: 216938:SHELI_RS04470
uniprot id: A0A1B3SLP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

216938:SHELI RS02820
gene id: 216938:SHELI_RS02820
uniprot id: A0A1B3SKQ4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

216938:SHELI RS01430
gene id: 216938:SHELI_RS01430
uniprot id: A0A1B3SJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

216938:SHELI RS05800
gene id: 216938:SHELI_RS05800
uniprot id: A0A1B3SMC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

216938:SHELI RS04445
gene id: 216938:SHELI_RS04445
uniprot id: A0A1B3SLK2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

216938:SHELI RS05735
gene id: 216938:SHELI_RS05735
uniprot id: A0A1B3SMB8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01190
gene id: 216938:SHELI_RS01190
uniprot id: A0A1B3SJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

216938:SHELI RS01465
gene id: 216938:SHELI_RS01465
uniprot id: A0A1B3SJW7
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216938:SHELI RS01615
gene id: 216938:SHELI_RS01615
uniprot id: A0A1B3SK14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

216938:SHELI RS03390
gene id: 216938:SHELI_RS03390
uniprot id: A0A1B3SL26
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

216938:SHELI RS02965
gene id: 216938:SHELI_RS02965
uniprot id: A0A1B3SKR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

216938:SHELI RS04555
gene id: 216938:SHELI_RS04555
uniprot id: A0A1B3SLP4
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

216938:SHELI RS01720
gene id: 216938:SHELI_RS01720
uniprot id: A0A1B3SK27
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

216938:SHELI RS04910
gene id: 216938:SHELI_RS04910
uniprot id: A0A1B3SLX7
names: Similarity
messages: Belongs to the LacAB/RpiB family.

216938:SHELI RS04885
gene id: 216938:SHELI_RS04885
uniprot id: A0A1B3SLU4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

216938:SHELI RS01860
gene id: 216938:SHELI_RS01860
uniprot id: A0A1B3SK59
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

216938:SHELI RS05765
gene id: 216938:SHELI_RS05765
uniprot id: A0A1B3SMC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

216938:SHELI RS03065
gene id: 216938:SHELI_RS03065
uniprot id: A0A1B3SKT9
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03165
gene id: 216938:SHELI_RS03165
uniprot id: A0A1B3SKW0
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

216938:SHELI RS04115
gene id: 216938:SHELI_RS04115
uniprot id: A0A1B3SLF5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216938:SHELI RS05205
gene id: 216938:SHELI_RS05205
uniprot id: A0A1B3SM28
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00090
gene id: 216938:SHELI_RS00090
uniprot id: A0A1B3SJ64
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

216938:SHELI RS02545
gene id: 216938:SHELI_RS02545
uniprot id: A0A1B3SKK5
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03525
gene id: 216938:SHELI_RS03525
uniprot id: A0A1B3SL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS01075
gene id: 216938:SHELI_RS01075
uniprot id: A0A1B3SJP5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03595
gene id: 216938:SHELI_RS03595
uniprot id: A0A1B3SL44
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

216938:SHELI RS00280
gene id: 216938:SHELI_RS00280
uniprot id: A0A1B3SJA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

216938:SHELI RS00565
gene id: 216938:SHELI_RS00565
uniprot id: A0A1B3SJG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

216938:SHELI RS04975
gene id: 216938:SHELI_RS04975
uniprot id: A0A1B3SLV6
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS05350
gene id: 216938:SHELI_RS05350
uniprot id: A0A1B3SM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

216938:SHELI RS05860
gene id: 216938:SHELI_RS05860
uniprot id: A0A1B3SME3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS02905
gene id: 216938:SHELI_RS02905
uniprot id: A0A1B3SKS8
names: Similarity
messages: Belongs to the NusB family.

216938:SHELI RS02645
gene id: 216938:SHELI_RS02645
uniprot id: A0A1B3SKM3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

216938:SHELI RS01775
gene id: 216938:SHELI_RS01775
uniprot id: A0A1B3SK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

216938:SHELI RS05975
gene id: 216938:SHELI_RS05975
uniprot id: A0A1B3SJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS04380
gene id: 216938:SHELI_RS04380
uniprot id: A0A1B3SLJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

216938:SHELI RS00375
gene id: 216938:SHELI_RS00375
uniprot id: A0A1B3SJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

216938:SHELI RS03060
gene id: 216938:SHELI_RS03060
uniprot id: A0A1B3SKU2
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

216938:SHELI RS02915
gene id: 216938:SHELI_RS02915
uniprot id: A0A1B3SKQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

216938:SHELI RS04460
gene id: 216938:SHELI_RS04460
uniprot id: A0A1B3SLK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

216938:SHELI RS04070
gene id: 216938:SHELI_RS04070
uniprot id: A0A1B3SLE4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216938:SHELI RS05300
gene id: 216938:SHELI_RS05300
uniprot id: A0A1B3SM47
names: Subcellular Location Annotation
messages: Cytoplasm

216938:SHELI RS03585
gene id: 216938:SHELI_RS03585
uniprot id: A0A1B3SL53
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

216938:SHELI RS03240
gene id: 216938:SHELI_RS03240
uniprot id: A0A1B3SKZ2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

216938:SHELI RS04315
gene id: 216938:SHELI_RS04315
uniprot id: A0A1B3SLI3
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00340
gene id: 216938:SHELI_RS00340
uniprot id: A0A1B3SJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

216938:SHELI RS02065
gene id: 216938:SHELI_RS02065
uniprot id: A0A1B3SK91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS02535
gene id: 216938:SHELI_RS02535
uniprot id: A0A1B3SKJ2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

216938:SHELI RS01315
gene id: 216938:SHELI_RS01315
uniprot id: A0A1B3SJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

216938:SHELI RS01670
gene id: 216938:SHELI_RS01670
uniprot id: A0A1B3SK16
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

216938:SHELI RS00615
gene id: 216938:SHELI_RS00615
uniprot id: A0A1B3SJH7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

216938:SHELI RS00290
gene id: 216938:SHELI_RS00290
uniprot id: A0A1B3SJA2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

216938:SHELI RS01645
gene id: 216938:SHELI_RS01645
uniprot id: A0A1B3SK12
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

216938:SHELI RS01165
gene id: 216938:SHELI_RS01165
uniprot id: A0A1B3SJS1
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

216938:SHELI RS01390
gene id: 216938:SHELI_RS01390
uniprot id: A0A1B3SJV9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

216938:SHELI RS04395
gene id: 216938:SHELI_RS04395
uniprot id: A0A1B3SLJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

216938:SHELI RS03485
gene id: 216938:SHELI_RS03485
uniprot id: A0A1B3SL35
names: Similarity
messages: Belongs to the peptidase M24B family.

216938:SHELI RS00025
gene id: 216938:SHELI_RS00025
uniprot id: A0A1B3SJ59
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00715
gene id: 216938:SHELI_RS00715
uniprot id: A0A1B3SJJ4
names: Similarity
messages: Belongs to the thioredoxin family.

216938:SHELI RS01285
gene id: 216938:SHELI_RS01285
uniprot id: A0A1B3SJT9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

216938:SHELI RS04665
gene id: 216938:SHELI_RS04665
uniprot id: A0A1B3SLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS00095
gene id: 216938:SHELI_RS00095
uniprot id: A0A1B3SJ61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS04250
gene id: 216938:SHELI_RS04250
uniprot id: A0A1B3SLF6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03915
gene id: 216938:SHELI_RS03915
uniprot id: A0A1B3SLB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

216938:SHELI RS00015
gene id: 216938:SHELI_RS00015
uniprot id: A0A1B3SJ45
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

216938:SHELI RS03895
gene id: 216938:SHELI_RS03895
uniprot id: A0A1B3SLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

216938:SHELI RS03375
gene id: 216938:SHELI_RS03375
uniprot id: A0A1B3SL06
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

216938:SHELI RS00480
gene id: 216938:SHELI_RS00480
uniprot id: A0A1B3SJF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

216938:SHELI RS02405
gene id: 216938:SHELI_RS02405
uniprot id: A0A1B3SKG4
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216938:SHELI RS02255
gene id: 216938:SHELI_RS02255
uniprot id: A0A1B3SKD1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

216938:SHELI RS00735
gene id: 216938:SHELI_RS00735
uniprot id: A0A1B3SJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS04285
gene id: 216938:SHELI_RS04285
uniprot id: A0A1B3SLI6
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS05410
gene id: 216938:SHELI_RS05410
uniprot id: A0A1B3SM46
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

216938:SHELI RS00450
gene id: 216938:SHELI_RS00450
uniprot id: A0A1B3SJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

216938:SHELI RS00370
gene id: 216938:SHELI_RS00370
uniprot id: A0A1B3SJC2
names: Similarity
messages: Belongs to the IMPACT family.

216938:SHELI RS04725
gene id: 216938:SHELI_RS04725
uniprot id: A0A1B3SLT8
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

216938:SHELI RS01835
gene id: 216938:SHELI_RS01835
uniprot id: A0A1B3SK47
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

216938:SHELI RS00020
gene id: 216938:SHELI_RS00020
uniprot id: A0A1B3SJ47
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

216938:SHELI RS05750
gene id: 216938:SHELI_RS05750
uniprot id: A0A1B3SMC0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216938:SHELI RS03275
gene id: 216938:SHELI_RS03275
uniprot id: A0A1B3SKY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS05490
gene id: 216938:SHELI_RS05490
uniprot id: A0A1B3SM67
names: Similarity
messages: Belongs to the peptidase M17 family.

216938:SHELI RS01520
gene id: 216938:SHELI_RS01520
uniprot id: A0A1B3SJY7
names: Similarity
messages: Belongs to the DprA/Smf family.

216938:SHELI RS05355
gene id: 216938:SHELI_RS05355
uniprot id: A0A1B3SM38
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

216938:SHELI RS04860
gene id: 216938:SHELI_RS04860
uniprot id: A0A1B3SLT6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

216938:SHELI RS03195
gene id: 216938:SHELI_RS03195
uniprot id: A0A1B3SKV0
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS04710
gene id: 216938:SHELI_RS04710
uniprot id: A0A1B3SLR9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

216938:SHELI RS04120
gene id: 216938:SHELI_RS04120
uniprot id: A0A1B3SLF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

216938:SHELI RS04945
gene id: 216938:SHELI_RS04945
uniprot id: A0A1B3SLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS04995
gene id: 216938:SHELI_RS04995
uniprot id: A0A1B3SLW4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

216938:SHELI RS03810
gene id: 216938:SHELI_RS03810
uniprot id: A0A1B3SL86
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

216938:SHELI RS04010
gene id: 216938:SHELI_RS04010
uniprot id: A0A1B3SLB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

216938:SHELI RS05570
gene id: 216938:SHELI_RS05570
uniprot id: A0A1B3SM85
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

216938:SHELI RS01710
gene id: 216938:SHELI_RS01710
uniprot id: A0A1B3SK29
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

216938:SHELI RS05745
gene id: 216938:SHELI_RS05745
uniprot id: A0A1B3SMD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

216938:SHELI RS01200
gene id: 216938:SHELI_RS01200
uniprot id: A0A1B3SJS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

216938:SHELI RS04750
gene id: 216938:SHELI_RS04750
uniprot id: A0A1B3SLR3
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS04100
gene id: 216938:SHELI_RS04100
uniprot id: A0A1B3SLE0
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01095
gene id: 216938:SHELI_RS01095
uniprot id: A0A1B3SJP9
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01180
gene id: 216938:SHELI_RS01180
uniprot id: A0A1B3SJR3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

216938:SHELI RS03645
gene id: 216938:SHELI_RS03645
uniprot id: A0A1B3SL57
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS02860
gene id: 216938:SHELI_RS02860
uniprot id: A0A1B3SKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

216938:SHELI RS04560
gene id: 216938:SHELI_RS04560
uniprot id: A0A1B3SLN0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

216938:SHELI RS03080
gene id: 216938:SHELI_RS03080
uniprot id: A0A1B3SKV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

216938:SHELI RS04375
gene id: 216938:SHELI_RS04375
uniprot id: A0A1B3SLJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

216938:SHELI RS00295
gene id: 216938:SHELI_RS00295
uniprot id: A0A1B3SJA7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

216938:SHELI RS03245
gene id: 216938:SHELI_RS03245
uniprot id: A0A1B3SKW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS02550
gene id: 216938:SHELI_RS02550
uniprot id: A0A1B3SKK2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

216938:SHELI RS03615
gene id: 216938:SHELI_RS03615
uniprot id: A0A1B3SL48
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

216938:SHELI RS00005
gene id: 216938:SHELI_RS00005
uniprot id: A0A1B3SJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

216938:SHELI RS05850
gene id: 216938:SHELI_RS05850
uniprot id: A0A1B3SMF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS05000
gene id: 216938:SHELI_RS05000
uniprot id: A0A1B3SLV8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01630
gene id: 216938:SHELI_RS01630
uniprot id: A0A1B3SK05
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

216938:SHELI RS02260
gene id: 216938:SHELI_RS02260
uniprot id: A0A1B3SKE3
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

216938:SHELI RS00435
gene id: 216938:SHELI_RS00435
uniprot id: A0A1B3SJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS00335
gene id: 216938:SHELI_RS00335
uniprot id: A0A1B3SJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

216938:SHELI RS02455
gene id: 216938:SHELI_RS02455
uniprot id: A0A1B3SKH8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03405
gene id: 216938:SHELI_RS03405
uniprot id: A0A1B3SL25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS02565
gene id: 216938:SHELI_RS02565
uniprot id: A0A1B3SKI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS01770
gene id: 216938:SHELI_RS01770
uniprot id: A0A1B3SK38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

216938:SHELI RS04130
gene id: 216938:SHELI_RS04130
uniprot id: A0A1B3SLE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS04775
gene id: 216938:SHELI_RS04775
uniprot id: A0A1B3SLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.
messages: Membrane

216938:SHELI RS04475
gene id: 216938:SHELI_RS04475
uniprot id: A0A1B3SLK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

216938:SHELI RS03850
gene id: 216938:SHELI_RS03850
uniprot id: A0A1B3SLA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

216938:SHELI RS01455
gene id: 216938:SHELI_RS01455
uniprot id: A0A1B3SJX9
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216938:SHELI RS00730
gene id: 216938:SHELI_RS00730
uniprot id: A0A1B3SJI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS03475
gene id: 216938:SHELI_RS03475
uniprot id: A0A1B3SL22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

216938:SHELI RS01115
gene id: 216938:SHELI_RS01115
uniprot id: A0A1B3SJR1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

216938:SHELI RS00385
gene id: 216938:SHELI_RS00385
uniprot id: A0A1B3SJD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

216938:SHELI RS04310
gene id: 216938:SHELI_RS04310
uniprot id: A0A1B3SLI0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03425
gene id: 216938:SHELI_RS03425
uniprot id: A0A1B3SL16
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

216938:SHELI RS05795
gene id: 216938:SHELI_RS05795
uniprot id: A0A1B3SMD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

216938:SHELI RS04030
gene id: 216938:SHELI_RS04030
uniprot id: A0A1B3SLC6
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01905
gene id: 216938:SHELI_RS01905
uniprot id: A0A1B3SK67
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00900
gene id: 216938:SHELI_RS00900
uniprot id: A0A1B3SJL6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS04420
gene id: 216938:SHELI_RS04420
uniprot id: A0A1B3SLM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

216938:SHELI RS01270
gene id: 216938:SHELI_RS01270
uniprot id: A0A1B3SJT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

216938:SHELI RS03055
gene id: 216938:SHELI_RS03055
uniprot id: A0A1B3SKV5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

216938:SHELI RS03400
gene id: 216938:SHELI_RS03400
uniprot id: A0A1B3SL14
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

216938:SHELI RS05730
gene id: 216938:SHELI_RS05730
uniprot id: A0A1B3SMB7
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01855
gene id: 216938:SHELI_RS01855
uniprot id: A0A1B3SK54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

216938:SHELI RS03855
gene id: 216938:SHELI_RS03855
uniprot id: A0A1B3SL81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

216938:SHELI RS02705
gene id: 216938:SHELI_RS02705
uniprot id: A0A1B3SKN5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

216938:SHELI RS03555
gene id: 216938:SHELI_RS03555
uniprot id: A0A1B3SL30
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

216938:SHELI RS03570
gene id: 216938:SHELI_RS03570
uniprot id: A0A1B3SL50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS02235
gene id: 216938:SHELI_RS02235
uniprot id: A0A1B3SKD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

216938:SHELI RS03980
gene id: 216938:SHELI_RS03980
uniprot id: A0A1B3SLB5
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.

216938:SHELI RS03040
gene id: 216938:SHELI_RS03040
uniprot id: A0A1B3SKV7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

216938:SHELI RS06080
gene id: 216938:SHELI_RS06080
uniprot id: A0A1B3SJP8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03465
gene id: 216938:SHELI_RS03465
uniprot id: A0A1B3SL19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

216938:SHELI RS04245
gene id: 216938:SHELI_RS04245
uniprot id: A0A1B3SLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

216938:SHELI RS02765
gene id: 216938:SHELI_RS02765
uniprot id: A0A1B3SKM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

216938:SHELI RS01360
gene id: 216938:SHELI_RS01360
uniprot id: A0A1B3SJV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03460
gene id: 216938:SHELI_RS03460
uniprot id: A0A1B3SL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

216938:SHELI RS00630
gene id: 216938:SHELI_RS00630
uniprot id: A0A1B3SJI4
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03985
gene id: 216938:SHELI_RS03985
uniprot id: A0A1B3SLB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

216938:SHELI RS04610
gene id: 216938:SHELI_RS04610
uniprot id: A0A1B3SLN8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

216938:SHELI RS02505
gene id: 216938:SHELI_RS02505
uniprot id: A0A1B3SKJ8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03215
gene id: 216938:SHELI_RS03215
uniprot id: A0A1B3SKW9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

216938:SHELI RS01380
gene id: 216938:SHELI_RS01380
uniprot id: A0A1B3SJV2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

216938:SHELI RS03030
gene id: 216938:SHELI_RS03030
uniprot id: A0A1B3SKV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

216938:SHELI RS05265
gene id: 216938:SHELI_RS05265
uniprot id: A0A1B3SM41
names: Subcellular Location Annotation
messages: cytosol

216938:SHELI RS01470
gene id: 216938:SHELI_RS01470
uniprot id: A0A1B3SJX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216938:SHELI RS04455
gene id: 216938:SHELI_RS04455
uniprot id: A0A1B3SLL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

216938:SHELI RS04685
gene id: 216938:SHELI_RS04685
uniprot id: A0A1B3SLR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

216938:SHELI RS04225
gene id: 216938:SHELI_RS04225
uniprot id: A0A1B3SLG1
names: Similarity
messages: Belongs to the peptidase M13 family.

216938:SHELI RS03705
gene id: 216938:SHELI_RS03705
uniprot id: A0A1B3SL64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216938:SHELI RS04950
gene id: 216938:SHELI_RS04950
uniprot id: A0A1B3SLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS01655
gene id: 216938:SHELI_RS01655
uniprot id: A0A1B3SK18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03955
gene id: 216938:SHELI_RS03955
uniprot id: A0A1B3SLC8
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01640
gene id: 216938:SHELI_RS01640
uniprot id: A0A1B3SK03
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

216938:SHELI RS04465
gene id: 216938:SHELI_RS04465
uniprot id: A0A1B3SLK6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

216938:SHELI RS03680
gene id: 216938:SHELI_RS03680
uniprot id: A0A1B3SL61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

216938:SHELI RS00130
gene id: 216938:SHELI_RS00130
uniprot id: A0A1B3SJ80
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

216938:SHELI RS00410
gene id: 216938:SHELI_RS00410
uniprot id: A0A1B3SJD4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

216938:SHELI RS00175
gene id: 216938:SHELI_RS00175
uniprot id: A0A1B3SJ90
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

216938:SHELI RS05050
gene id: 216938:SHELI_RS05050
uniprot id: A0A1B3SLX0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

216938:SHELI RS00325
gene id: 216938:SHELI_RS00325
uniprot id: A0A1B3SJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

216938:SHELI RS05845
gene id: 216938:SHELI_RS05845
uniprot id: A0A1B3SME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

216938:SHELI RS05520
gene id: 216938:SHELI_RS05520
uniprot id: A0A1B3SM69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

216938:SHELI RS03750
gene id: 216938:SHELI_RS03750
uniprot id: A0A1B3SL60
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

216938:SHELI RS04925
gene id: 216938:SHELI_RS04925
uniprot id: A0A1B3SLW3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

216938:SHELI RS02620
gene id: 216938:SHELI_RS02620
uniprot id: A0A1B3SKJ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

216938:SHELI RS00860
gene id: 216938:SHELI_RS00860
uniprot id: A0A1B3SJL4
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

216938:SHELI RS01135
gene id: 216938:SHELI_RS01135
uniprot id: A0A1B3SJQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS00895
gene id: 216938:SHELI_RS00895
uniprot id: A0A1B3SJL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

216938:SHELI RS00540
gene id: 216938:SHELI_RS00540
uniprot id: A0A1B3SJG4
names: Subcellular Location Annotation
messages: Cytoplasm

216938:SHELI RS02880
gene id: 216938:SHELI_RS02880
uniprot id: A0A1B3SKR9
names: Similarity
messages: Belongs to the TlyA family.

216938:SHELI RS05320
gene id: 216938:SHELI_RS05320
uniprot id: A0A1B3SM24
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

216938:SHELI RS01265
gene id: 216938:SHELI_RS01265
uniprot id: A0A1B3SJU0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03690
gene id: 216938:SHELI_RS03690
uniprot id: A0A1B3SL54
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

216938:SHELI RS04670
gene id: 216938:SHELI_RS04670
uniprot id: A0A1B3SLT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS00050
gene id: 216938:SHELI_RS00050
uniprot id: A0A1B3SJ53
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

216938:SHELI RS02075
gene id: 216938:SHELI_RS02075
uniprot id: A0A1B3SKA0
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

216938:SHELI RS00420
gene id: 216938:SHELI_RS00420
uniprot id: A0A1B3SJD5
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

216938:SHELI RS00310
gene id: 216938:SHELI_RS00310
uniprot id: A0A1B3SJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

216938:SHELI RS05610
gene id: 216938:SHELI_RS05610
uniprot id: A0A1B3SM90
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

216938:SHELI RS04055
gene id: 216938:SHELI_RS04055
uniprot id: A0A1B3SLF0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

216938:SHELI RS00070
gene id: 216938:SHELI_RS00070
uniprot id: A0A1B3SJ65
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS05440
gene id: 216938:SHELI_RS05440
uniprot id: A0A1B3SM59
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

216938:SHELI RS03430
gene id: 216938:SHELI_RS03430
uniprot id: A0A1B3SL20
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

216938:SHELI RS04005
gene id: 216938:SHELI_RS04005
uniprot id: A0A1B3SLD7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00040
gene id: 216938:SHELI_RS00040
uniprot id: A0A1B3SJ55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

216938:SHELI RS04920
gene id: 216938:SHELI_RS04920
uniprot id: A0A1B3SLV3
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS01585
gene id: 216938:SHELI_RS01585
uniprot id: A0A1B3SJZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

216938:SHELI RS03910
gene id: 216938:SHELI_RS03910
uniprot id: A0A1B3SLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

216938:SHELI RS01405
gene id: 216938:SHELI_RS01405
uniprot id: A0A1B3SJX2
names: Subcellular Location Annotation
messages: Cytoplasm

216938:SHELI RS04590
gene id: 216938:SHELI_RS04590
uniprot id: A0A1B3SLP2
names: Similarity
messages: Belongs to the CutC family.

216938:SHELI RS02875
gene id: 216938:SHELI_RS02875
uniprot id: A0A1B3SKQ6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

216938:SHELI RS01025
gene id: 216938:SHELI_RS01025
uniprot id: A0A1B3SJN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

216938:SHELI RS02940
gene id: 216938:SHELI_RS02940
uniprot id: A0A1B3SKT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

216938:SHELI RS05675
gene id: 216938:SHELI_RS05675
uniprot id: A0A1B3SMA1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00350
gene id: 216938:SHELI_RS00350
uniprot id: A0A1B3SJB9
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS05485
gene id: 216938:SHELI_RS05485
uniprot id: A0A1B3SM65
names: Similarity
messages: Belongs to the peptidase M17 family.

216938:SHELI RS00195
gene id: 216938:SHELI_RS00195
uniprot id: A0A1B3SJ85
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

216938:SHELI RS02815
gene id: 216938:SHELI_RS02815
uniprot id: A0A1B3SKN4
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS04205
gene id: 216938:SHELI_RS04205
uniprot id: A0A1B3SLG0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

216938:SHELI RS04855
gene id: 216938:SHELI_RS04855
uniprot id: A0A1B3SLU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

216938:SHELI RS02050
gene id: 216938:SHELI_RS02050
uniprot id: A0A1B3SK85
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216938:SHELI RS01110
gene id: 216938:SHELI_RS01110
uniprot id: A0A1B3SJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

216938:SHELI RS00065
gene id: 216938:SHELI_RS00065
uniprot id: A0A1B3SJ71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

216938:SHELI RS00240
gene id: 216938:SHELI_RS00240
uniprot id: A0A1B3SJ94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

216938:SHELI RS03310
gene id: 216938:SHELI_RS03310
uniprot id: A0A1B3SKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS00115
gene id: 216938:SHELI_RS00115
uniprot id: A0A1B3SJ81
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS01035
gene id: 216938:SHELI_RS01035
uniprot id: A0A1B3SJN6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00355
gene id: 216938:SHELI_RS00355
uniprot id: A0A1B3SJB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216938:SHELI RS03605
gene id: 216938:SHELI_RS03605
uniprot id: A0A1B3SL41
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

216938:SHELI RS04370
gene id: 216938:SHELI_RS04370
uniprot id: A0A1B3SLM1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

216938:SHELI RS00905
gene id: 216938:SHELI_RS00905
uniprot id: A0A1B3SJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

216938:SHELI RS04450
gene id: 216938:SHELI_RS04450
uniprot id: A0A1B3SLK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

216938:SHELI RS03455
gene id: 216938:SHELI_RS03455
uniprot id: A0A1B3SL36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

216938:SHELI RS00645
gene id: 216938:SHELI_RS00645
uniprot id: A0A1B3SJH1
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00200
gene id: 216938:SHELI_RS00200
uniprot id: A0A1B3SJ88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

216938:SHELI RS05805
gene id: 216938:SHELI_RS05805
uniprot id: A0A1B3SMF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS04850
gene id: 216938:SHELI_RS04850
uniprot id: A0A1B3SLV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

216938:SHELI RS04425
gene id: 216938:SHELI_RS04425
uniprot id: A0A1B3SLK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

216938:SHELI RS00525
gene id: 216938:SHELI_RS00525
uniprot id: A0A1B3SJF4
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00415
gene id: 216938:SHELI_RS00415
uniprot id: A0A1B3SJD1
names: Similarity
messages: Belongs to the Lgt family.

216938:SHELI RS04490
gene id: 216938:SHELI_RS04490
uniprot id: A0A1B3SLM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

216938:SHELI RS01385
gene id: 216938:SHELI_RS01385
uniprot id: A0A1B3SJV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

216938:SHELI RS00945
gene id: 216938:SHELI_RS00945
uniprot id: A0A1B3SJL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

216938:SHELI RS05880
gene id: 216938:SHELI_RS05880
uniprot id: A0A1B3SME8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

216938:SHELI RS03905
gene id: 216938:SHELI_RS03905
uniprot id: A0A1B3SL91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

216938:SHELI RS05810
gene id: 216938:SHELI_RS05810
uniprot id: A0A1B3SMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm

216938:SHELI RS04275
gene id: 216938:SHELI_RS04275
uniprot id: A0A1B3SLH2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

216938:SHELI RS05670
gene id: 216938:SHELI_RS05670
uniprot id: A0A1B3SMA3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

216938:SHELI RS03035
gene id: 216938:SHELI_RS03035
uniprot id: A0A1B3SKU3
names: Similarity
messages: Belongs to the peptidase S66 family.

216938:SHELI RS03730
gene id: 216938:SHELI_RS03730
uniprot id: A0A1B3SL88
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

216938:SHELI RS01940
gene id: 216938:SHELI_RS01940
uniprot id: A0A1B3SK64
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

216938:SHELI RS04385
gene id: 216938:SHELI_RS04385
uniprot id: A0A1B3SLL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS04075
gene id: 216938:SHELI_RS04075
uniprot id: A0A1B3SLE1
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

216938:SHELI RS01955
gene id: 216938:SHELI_RS01955
uniprot id: A0A1B3SK78
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216938:SHELI RS02010
gene id: 216938:SHELI_RS02010
uniprot id: A0A1B3SK80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

216938:SHELI RS03370
gene id: 216938:SHELI_RS03370
uniprot id: A0A1B3SL17
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

216938:SHELI RS00125
gene id: 216938:SHELI_RS00125
uniprot id: A0A1B3SJ74
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

216938:SHELI RS03565
gene id: 216938:SHELI_RS03565
uniprot id: A0A1B3SL39
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

216938:SHELI RS05540
gene id: 216938:SHELI_RS05540
uniprot id: A0A1B3SM80
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS04105
gene id: 216938:SHELI_RS04105
uniprot id: A0A1B3SLG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

216938:SHELI RS00315
gene id: 216938:SHELI_RS00315
uniprot id: A0A1B3SJB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

216938:SHELI RS00885
gene id: 216938:SHELI_RS00885
uniprot id: A0A1B3SJK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

216938:SHELI RS01375
gene id: 216938:SHELI_RS01375
uniprot id: A0A1B3SJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

216938:SHELI RS01560
gene id: 216938:SHELI_RS01560
uniprot id: A0A1B3SJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

216938:SHELI RS04045
gene id: 216938:SHELI_RS04045
uniprot id: A0A1B3SLC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS02635
gene id: 216938:SHELI_RS02635
uniprot id: A0A1B3SKM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS01530
gene id: 216938:SHELI_RS01530
uniprot id: A0A1B3SJY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

216938:SHELI RS00445
gene id: 216938:SHELI_RS00445
uniprot id: A0A1B3SJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

216938:SHELI RS01225
gene id: 216938:SHELI_RS01225
uniprot id: A0A1B3SJS6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

216938:SHELI RS01045
gene id: 216938:SHELI_RS01045
uniprot id: A0A1B3SJN9
names: Similarity
messages: Belongs to the pyruvate kinase family.

216938:SHELI RS05680
gene id: 216938:SHELI_RS05680
uniprot id: A0A1B3SMA9
names: Similarity
messages: Belongs to the RpoE family.

216938:SHELI RS03965
gene id: 216938:SHELI_RS03965
uniprot id: A0A1B3SLC7
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS05770
gene id: 216938:SHELI_RS05770
uniprot id: A0A1B3SMC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

216938:SHELI RS00400
gene id: 216938:SHELI_RS00400
uniprot id: A0A1B3SJC8
names: Similarity
messages: Belongs to the HPrK/P family.

216938:SHELI RS04350
gene id: 216938:SHELI_RS04350
uniprot id: A0A1B3SLH8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

216938:SHELI RS01580
gene id: 216938:SHELI_RS01580
uniprot id: A0A1B3SJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS03875
gene id: 216938:SHELI_RS03875
uniprot id: A0A1B3SL99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216938:SHELI RS05435
gene id: 216938:SHELI_RS05435
uniprot id: A0A1B3SM60
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03470
gene id: 216938:SHELI_RS03470
uniprot id: A0A1B3SL34
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS05530
gene id: 216938:SHELI_RS05530
uniprot id: A0A1B3SM73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

216938:SHELI RS05725
gene id: 216938:SHELI_RS05725
uniprot id: A0A1B3SMB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

216938:SHELI RS04240
gene id: 216938:SHELI_RS04240
uniprot id: A0A1B3SLG8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

216938:SHELI RS01995
gene id: 216938:SHELI_RS01995
uniprot id: A0A1B3SK70
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

216938:SHELI RS00110
gene id: 216938:SHELI_RS00110
uniprot id: A0A1B3SJ69
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

216938:SHELI RS04355
gene id: 216938:SHELI_RS04355
uniprot id: A0A1B3SLJ4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

216938:SHELI RS00330
gene id: 216938:SHELI_RS00330
uniprot id: A0A1B3SJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

216938:SHELI RS00500
gene id: 216938:SHELI_RS00500
uniprot id: A0A1B3SJE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

216938:SHELI RS04265
gene id: 216938:SHELI_RS04265
uniprot id: A0A1B3SLH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS05875
gene id: 216938:SHELI_RS05875
uniprot id: A0A1B3SME6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

216938:SHELI RS05500
gene id: 216938:SHELI_RS05500
uniprot id: A0A1B3SM84
names: Similarity
messages: Belongs to the peptidase M17 family.

216938:SHELI RS01060
gene id: 216938:SHELI_RS01060
uniprot id: A0A1B3SJP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216938:SHELI RS05605
gene id: 216938:SHELI_RS05605
uniprot id: A0A1B3SM87
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

216938:SHELI RS02265
gene id: 216938:SHELI_RS02265
uniprot id: A0A1B3SKD4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

216938:SHELI RS04185
gene id: 216938:SHELI_RS04185
uniprot id: A0A1B3SLF9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

216938:SHELI RS03820
gene id: 216938:SHELI_RS03820
uniprot id: A0A1B3SL84
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

216938:SHELI RS00045
gene id: 216938:SHELI_RS00045
uniprot id: A0A1B3SJ51
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

216938:SHELI RS01040
gene id: 216938:SHELI_RS01040
uniprot id: A0A1B3SJN8
names: Similarity
messages: Belongs to the pyruvate kinase family.

216938:SHELI RS04410
gene id: 216938:SHELI_RS04410
uniprot id: A0A1B3SLJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

216938:SHELI RS04235
gene id: 216938:SHELI_RS04235
uniprot id: A0A1B3SLH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

216938:SHELI RS03135
gene id: 216938:SHELI_RS03135
uniprot id: A0A1B3SKW1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

216938:SHELI RS03780
gene id: 216938:SHELI_RS03780
uniprot id: A0A1B3SL79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS02570
gene id: 216938:SHELI_RS02570
uniprot id: A0A1B3SKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS03130
gene id: 216938:SHELI_RS03130
uniprot id: A0A1B3SKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

216938:SHELI RS04210
gene id: 216938:SHELI_RS04210
uniprot id: A0A1B3SLF8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

216938:SHELI RS05655
gene id: 216938:SHELI_RS05655
uniprot id: A0A1B3SM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

216938:SHELI RS00875
gene id: 216938:SHELI_RS00875
uniprot id: A0A1B3SJK0
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS01525
gene id: 216938:SHELI_RS01525
uniprot id: A0A1B3SJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS03490
gene id: 216938:SHELI_RS03490
uniprot id: A0A1B3SL40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

216938:SHELI RS01325
gene id: 216938:SHELI_RS01325
uniprot id: A0A1B3SJU5
names: Similarity
messages: Belongs to the FBPase class 2 family.

216938:SHELI RS02790
gene id: 216938:SHELI_RS02790
uniprot id: A0A1B3SKQ2
names: Similarity
messages: Belongs to the peptidase S66 family.

216938:SHELI RS00660
gene id: 216938:SHELI_RS00660
uniprot id: A0A1B3SJH2
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS04365
gene id: 216938:SHELI_RS04365
uniprot id: A0A1B3SLJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

216938:SHELI RS02900
gene id: 216938:SHELI_RS02900
uniprot id: A0A1B3SKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

216938:SHELI RS00235
gene id: 216938:SHELI_RS00235
uniprot id: A0A1B3SJ93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

216938:SHELI RS02245
gene id: 216938:SHELI_RS02245
uniprot id: A0A1B3SKC3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

216938:SHELI RS03305
gene id: 216938:SHELI_RS03305
uniprot id: A0A1B3SL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS03600
gene id: 216938:SHELI_RS03600
uniprot id: A0A1B3SL52
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00275
gene id: 216938:SHELI_RS00275
uniprot id: A0A1B3SJB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

216938:SHELI RS02640
gene id: 216938:SHELI_RS02640
uniprot id: A0A1B3SKM0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS03930
gene id: 216938:SHELI_RS03930
uniprot id: A0A1B3SLA2
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS05715
gene id: 216938:SHELI_RS05715
uniprot id: A0A1B3SMB4
names: Similarity
messages: Belongs to the ParB family.

216938:SHELI RS01400
gene id: 216938:SHELI_RS01400
uniprot id: A0A1B3SJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Cytoplasm

216938:SHELI RS03220
gene id: 216938:SHELI_RS03220
uniprot id: A0A1B3SKY7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

216938:SHELI RS03395
gene id: 216938:SHELI_RS03395
uniprot id: A0A1B3SL03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS01815
gene id: 216938:SHELI_RS01815
uniprot id: A0A1B3SK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS04095
gene id: 216938:SHELI_RS04095
uniprot id: A0A1B3SLD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

216938:SHELI RS01170
gene id: 216938:SHELI_RS01170
uniprot id: A0A1B3SJS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

216938:SHELI RS03115
gene id: 216938:SHELI_RS03115
uniprot id: A0A1B3SKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

216938:SHELI RS01635
gene id: 216938:SHELI_RS01635
uniprot id: A0A1B3SK08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

216938:SHELI RS04280
gene id: 216938:SHELI_RS04280
uniprot id: A0A1B3SLH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

216938:SHELI RS01755
gene id: 216938:SHELI_RS01755
uniprot id: A0A1B3SK36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

216938:SHELI RS02960
gene id: 216938:SHELI_RS02960
uniprot id: A0A1B3SKS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

216938:SHELI RS05445
gene id: 216938:SHELI_RS05445
uniprot id: A0A1B3SM56
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

216938:SHELI RS04255
gene id: 216938:SHELI_RS04255
uniprot id: A0A1B3SLH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

216938:SHELI RS00495
gene id: 216938:SHELI_RS00495
uniprot id: A0A1B3SJD7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

216938:SHELI RS00255
gene id: 216938:SHELI_RS00255
uniprot id: A0A1B3SJ97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS02890
gene id: 216938:SHELI_RS02890
uniprot id: A0A1B3SKS1
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

216938:SHELI RS05690
gene id: 216938:SHELI_RS05690
uniprot id: A0A1B3SMA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216938:SHELI RS05455
gene id: 216938:SHELI_RS05455
uniprot id: A0A1B3SM61
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

216938:SHELI RS04485
gene id: 216938:SHELI_RS04485
uniprot id: A0A1B3SLM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

216938:SHELI RS00440
gene id: 216938:SHELI_RS00440
uniprot id: A0A1B3SJC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

216938:SHELI RS03445
gene id: 216938:SHELI_RS03445
uniprot id: A0A1B3SL12
names: Similarity
messages: Belongs to the ABC transporter superfamily.

216938:SHELI RS03200
gene id: 216938:SHELI_RS03200
uniprot id: A0A1B3SKW4
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS00510
gene id: 216938:SHELI_RS00510
uniprot id: A0A1B3SJE3
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

216938:SHELI RS00485
gene id: 216938:SHELI_RS00485
uniprot id: A0A1B3SJF3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216938:SHELI RS00380
gene id: 216938:SHELI_RS00380
uniprot id: A0A1B3SJD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

216938:SHELI RS03935
gene id: 216938:SHELI_RS03935
uniprot id: A0A1B3SLC2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

216938:SHELI RS01495
gene id: 216938:SHELI_RS01495
uniprot id: A0A1B3SJY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

216938:SHELI RS04360
gene id: 216938:SHELI_RS04360
uniprot id: A0A1B3SLI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

216938:SHELI RS01010
gene id: 216938:SHELI_RS01010
uniprot id: A0A1B3SJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

216938:SHELI RS01240
gene id: 216938:SHELI_RS01240
uniprot id: A0A1B3SJT2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

216938:SHELI RS03800
gene id: 216938:SHELI_RS03800
uniprot id: A0A1B3SL98
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

216938:SHELI RS01015
gene id: 216938:SHELI_RS01015
uniprot id: A0A1B3SJP3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

216938:SHELI RS01785
gene id: 216938:SHELI_RS01785
uniprot id: A0A1B3SK34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

216938:SHELI RS02355
gene id: 216938:SHELI_RS02355
uniprot id: A0A1B3SKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216938:SHELI RS03095
gene id: 216938:SHELI_RS03095
uniprot id: A0A1B3SKT1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

216938:SHELI RS01510
gene id: 216938:SHELI_RS01510
uniprot id: A0A1B3SJZ1
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03610
gene id: 216938:SHELI_RS03610
uniprot id: A0A1B3SL51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

216938:SHELI RS00180
gene id: 216938:SHELI_RS00180
uniprot id: A0A1B3SJ83
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

216938:SHELI RS04630
gene id: 216938:SHELI_RS04630
uniprot id: A0A1B3SLP1
names: Subcellular Location Annotation
messages: Membrane

216938:SHELI RS03535
gene id: 216938:SHELI_RS03535
uniprot id: A0A1B3SL28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216938:SHELI RS01250
gene id: 216938:SHELI_RS01250
uniprot id: A0A1B3SJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

216938:SHELI RS00515
gene id: 216938:SHELI_RS00515
uniprot id: A0A1B3SJF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216938:SHELI RS01245
gene id: 216938:SHELI_RS01245
uniprot id: A0A1B3SJS4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

216938:SHELI RS03665
gene id: 216938:SHELI_RS03665
uniprot id: A0A1B3SL62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.