216427:CK556 RS03030
gene id: 216427:CK556_RS03030
uniprot id: A0A249SNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216427:CK556 RS01485
gene id: 216427:CK556_RS01485
uniprot id: A0A249SN20
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

216427:CK556 RS00685
gene id: 216427:CK556_RS00685
uniprot id: A0A249SMQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

216427:CK556 RS02665
gene id: 216427:CK556_RS02665
uniprot id: A0A249SNQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

216427:CK556 RS03525
gene id: 216427:CK556_RS03525
uniprot id: A0A249SP45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

216427:CK556 RS00510
gene id: 216427:CK556_RS00510
uniprot id: A0A249SMK7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS02990
gene id: 216427:CK556_RS02990
uniprot id: A0A249SNP7
names: Similarity
messages: Belongs to the DEAD box helicase family.

216427:CK556 RS03760
gene id: 216427:CK556_RS03760
uniprot id: A0A249SPN9
names: Similarity
messages: Belongs to the CutC family.

216427:CK556 RS03800
gene id: 216427:CK556_RS03800
uniprot id: A0A249SPD2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

216427:CK556 RS00855
gene id: 216427:CK556_RS00855
uniprot id: A0A249SMP4
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01260
gene id: 216427:CK556_RS01260
uniprot id: A0A249SMZ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

216427:CK556 RS00445
gene id: 216427:CK556_RS00445
uniprot id: A0A249SMD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

216427:CK556 RS00290
gene id: 216427:CK556_RS00290
uniprot id: A0A249SMD1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

216427:CK556 RS00580
gene id: 216427:CK556_RS00580
uniprot id: A0A249SMM8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

216427:CK556 RS03025
gene id: 216427:CK556_RS03025
uniprot id: A0A249SP85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

216427:CK556 RS01570
gene id: 216427:CK556_RS01570
uniprot id: A0A249SMY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

216427:CK556 RS03720
gene id: 216427:CK556_RS03720
uniprot id: A0A249SPA9
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03745
gene id: 216427:CK556_RS03745
uniprot id: A0A249SP60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

216427:CK556 RS03205
gene id: 216427:CK556_RS03205
uniprot id: A0A249SNY8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

216427:CK556 RS01380
gene id: 216427:CK556_RS01380
uniprot id: A0A249SN31
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

216427:CK556 RS01420
gene id: 216427:CK556_RS01420
uniprot id: A0A249SMW3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

216427:CK556 RS01105
gene id: 216427:CK556_RS01105
uniprot id: A0A249SMS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

216427:CK556 RS01880
gene id: 216427:CK556_RS01880
uniprot id: A0A249SN56
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

216427:CK556 RS00760
gene id: 216427:CK556_RS00760
uniprot id: A0A249SMR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

216427:CK556 RS03520
gene id: 216427:CK556_RS03520
uniprot id: A0A249SP04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

216427:CK556 RS03145
gene id: 216427:CK556_RS03145
uniprot id: A0A249SNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

216427:CK556 RS01010
gene id: 216427:CK556_RS01010
uniprot id: A0A249SMV5
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

216427:CK556 RS01315
gene id: 216427:CK556_RS01315
uniprot id: A0A249SMS9
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

216427:CK556 RS01615
gene id: 216427:CK556_RS01615
uniprot id: A0A249SN81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

216427:CK556 RS03595
gene id: 216427:CK556_RS03595
uniprot id: A0A249SP94
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

216427:CK556 RS02725
gene id: 216427:CK556_RS02725
uniprot id: A0A249SNT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216427:CK556 RS01135
gene id: 216427:CK556_RS01135
uniprot id: A0A249SMZ0
names: Subcellular Location Annotation
messages: Cytoplasm

216427:CK556 RS03695
gene id: 216427:CK556_RS03695
uniprot id: A0A249SP50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

216427:CK556 RS00870
gene id: 216427:CK556_RS00870
uniprot id: A0A249SMT1
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

216427:CK556 RS00710
gene id: 216427:CK556_RS00710
uniprot id: A0A249SMQ9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

216427:CK556 RS03775
gene id: 216427:CK556_RS03775
uniprot id: A0A249SP47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

216427:CK556 RS00455
gene id: 216427:CK556_RS00455
uniprot id: A0A249SML4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

216427:CK556 RS00305
gene id: 216427:CK556_RS00305
uniprot id: A0A249SMJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

216427:CK556 RS02690
gene id: 216427:CK556_RS02690
uniprot id: A0A249SNQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

216427:CK556 RS02930
gene id: 216427:CK556_RS02930
uniprot id: A0A249SNV8
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00490
gene id: 216427:CK556_RS00490
uniprot id: A0A249SMC9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

216427:CK556 RS00355
gene id: 216427:CK556_RS00355
uniprot id: A0A249SMJ4
names: Similarity
messages: Belongs to the IMPACT family.

216427:CK556 RS02365
gene id: 216427:CK556_RS02365
uniprot id: A0A249SNG1
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

216427:CK556 RS00985
gene id: 216427:CK556_RS00985
uniprot id: A0A249SMW0
names: Similarity
messages: Belongs to the pyruvate kinase family.

216427:CK556 RS01850
gene id: 216427:CK556_RS01850
uniprot id: A0A249SN72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

216427:CK556 RS01845
gene id: 216427:CK556_RS01845
uniprot id: A0A249SNB7
names: Similarity
messages: Belongs to the NusB family.

216427:CK556 RS02825
gene id: 216427:CK556_RS02825
uniprot id: A0A249SNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

216427:CK556 RS00015
gene id: 216427:CK556_RS00015
uniprot id: A0A249SM82
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

216427:CK556 RS03590
gene id: 216427:CK556_RS03590
uniprot id: A0A249SP30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

216427:CK556 RS01915
gene id: 216427:CK556_RS01915
uniprot id: A0A249SNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

216427:CK556 RS02320
gene id: 216427:CK556_RS02320
uniprot id: A0A249SNK5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

216427:CK556 RS01015
gene id: 216427:CK556_RS01015
uniprot id: A0A249SMU9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

216427:CK556 RS02310
gene id: 216427:CK556_RS02310
uniprot id: A0A249SNF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

216427:CK556 RS02940
gene id: 216427:CK556_RS02940
uniprot id: A0A249SNP0
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03675
gene id: 216427:CK556_RS03675
uniprot id: A0A249SP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

216427:CK556 RS03405
gene id: 216427:CK556_RS03405
uniprot id: A0A249SNY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

216427:CK556 RS00885
gene id: 216427:CK556_RS00885
uniprot id: A0A249SN49
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

216427:CK556 RS02795
gene id: 216427:CK556_RS02795
uniprot id: A0A249SNR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

216427:CK556 RS03470
gene id: 216427:CK556_RS03470
uniprot id: A0A249SNZ4
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

216427:CK556 RS00460
gene id: 216427:CK556_RS00460
uniprot id: A0A249SMJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

216427:CK556 RS03630
gene id: 216427:CK556_RS03630
uniprot id: A0A249SP62
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01575
gene id: 216427:CK556_RS01575
uniprot id: A0A249SMZ1
names: Similarity
messages: Belongs to the nitroreductase family.

216427:CK556 RS01040
gene id: 216427:CK556_RS01040
uniprot id: A0A249SMV8
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03410
gene id: 216427:CK556_RS03410
uniprot id: A0A249SNY7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

216427:CK556 RS02065
gene id: 216427:CK556_RS02065
uniprot id: A0A249SNT4
names: Similarity
messages: Belongs to the HAM1 NTPase family.

216427:CK556 RS03160
gene id: 216427:CK556_RS03160
uniprot id: A0A249SNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

216427:CK556 RS00725
gene id: 216427:CK556_RS00725
uniprot id: A0A249SMP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

216427:CK556 RS00300
gene id: 216427:CK556_RS00300
uniprot id: A0A249SMG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

216427:CK556 RS03480
gene id: 216427:CK556_RS03480
uniprot id: A0A249SP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

216427:CK556 RS03255
gene id: 216427:CK556_RS03255
uniprot id: A0A249SNZ8
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

216427:CK556 RS01585
gene id: 216427:CK556_RS01585
uniprot id: A0A249SN69
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS03065
gene id: 216427:CK556_RS03065
uniprot id: A0A249SNX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

216427:CK556 RS00610
gene id: 216427:CK556_RS00610
uniprot id: A0A249SMP0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

216427:CK556 RS01565
gene id: 216427:CK556_RS01565
uniprot id: A0A249SN70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

216427:CK556 RS00680
gene id: 216427:CK556_RS00680
uniprot id: A0A249SMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

216427:CK556 RS01000
gene id: 216427:CK556_RS01000
uniprot id: A0A249SMN3
names: Similarity
messages: Belongs to the thioredoxin family.

216427:CK556 RS00285
gene id: 216427:CK556_RS00285
uniprot id: A0A249SMA9
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

216427:CK556 RS00820
gene id: 216427:CK556_RS00820
uniprot id: A0A249SMT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

216427:CK556 RS03765
gene id: 216427:CK556_RS03765
uniprot id: A0A249SP96
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

216427:CK556 RS00830
gene id: 216427:CK556_RS00830
uniprot id: A0A249SN40
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

216427:CK556 RS02485
gene id: 216427:CK556_RS02485
uniprot id: A0A249SNZ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

216427:CK556 RS00435
gene id: 216427:CK556_RS00435
uniprot id: A0A249SMJ5
names: Similarity
messages: Belongs to the peptidase M17 family.

216427:CK556 RS00120
gene id: 216427:CK556_RS00120
uniprot id: A0A249SMA2
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00620
gene id: 216427:CK556_RS00620
uniprot id: A0A249SMQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

216427:CK556 RS03235
gene id: 216427:CK556_RS03235
uniprot id: A0A249SP24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS01590
gene id: 216427:CK556_RS01590
uniprot id: A0A249SN35
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03510
gene id: 216427:CK556_RS03510
uniprot id: A0A249SP70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

216427:CK556 RS01210
gene id: 216427:CK556_RS01210
uniprot id: A0A249SMR2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01235
gene id: 216427:CK556_RS01235
uniprot id: A0A249SN11
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.

216427:CK556 RS00980
gene id: 216427:CK556_RS00980
uniprot id: A0A249SN58
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS02010
gene id: 216427:CK556_RS02010
uniprot id: A0A249SNC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01710
gene id: 216427:CK556_RS01710
uniprot id: A0A249SNK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

216427:CK556 RS02355
gene id: 216427:CK556_RS02355
uniprot id: A0A249SNH6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

216427:CK556 RS01405
gene id: 216427:CK556_RS01405
uniprot id: A0A249SN32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01515
gene id: 216427:CK556_RS01515
uniprot id: A0A249SMX1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

216427:CK556 RS03705
gene id: 216427:CK556_RS03705
uniprot id: A0A249SP83
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS02015
gene id: 216427:CK556_RS02015
uniprot id: A0A249SNS2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS01115
gene id: 216427:CK556_RS01115
uniprot id: A0A249SMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

216427:CK556 RS00660
gene id: 216427:CK556_RS00660
uniprot id: A0A249SMQ3
names: Similarity
messages: Belongs to the OsmC/Ohr family.

216427:CK556 RS02295
gene id: 216427:CK556_RS02295
uniprot id: A0A249SND2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

216427:CK556 RS00640
gene id: 216427:CK556_RS00640
uniprot id: A0A249SMN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

216427:CK556 RS00080
gene id: 216427:CK556_RS00080
uniprot id: A0A249SMD0
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS02750
gene id: 216427:CK556_RS02750
uniprot id: A0A249SNM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

216427:CK556 RS01050
gene id: 216427:CK556_RS01050
uniprot id: A0A249SMN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

216427:CK556 RS02250
gene id: 216427:CK556_RS02250
uniprot id: A0A249SNG7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216427:CK556 RS00975
gene id: 216427:CK556_RS00975
uniprot id: A0A249SMU0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216427:CK556 RS03095
gene id: 216427:CK556_RS03095
uniprot id: A0A249SNS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

216427:CK556 RS00670
gene id: 216427:CK556_RS00670
uniprot id: A0A249SMR1
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

216427:CK556 RS00970
gene id: 216427:CK556_RS00970
uniprot id: A0A249SMV7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216427:CK556 RS00025
gene id: 216427:CK556_RS00025
uniprot id: A0A249SMB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

216427:CK556 RS00785
gene id: 216427:CK556_RS00785
uniprot id: A0A249SMS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

216427:CK556 RS00395
gene id: 216427:CK556_RS00395
uniprot id: A0A249SMC6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

216427:CK556 RS01960
gene id: 216427:CK556_RS01960
uniprot id: A0A249SNB6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

216427:CK556 RS01285
gene id: 216427:CK556_RS01285
uniprot id: A0A249SMZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

216427:CK556 RS00765
gene id: 216427:CK556_RS00765
uniprot id: A0A249SMR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

216427:CK556 RS00715
gene id: 216427:CK556_RS00715
uniprot id: A0A249SMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

216427:CK556 RS03475
gene id: 216427:CK556_RS03475
uniprot id: A0A249SP37
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS00850
gene id: 216427:CK556_RS00850
uniprot id: A0A249SML5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS03620
gene id: 216427:CK556_RS03620
uniprot id: A0A249SP18
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

216427:CK556 RS03085
gene id: 216427:CK556_RS03085
uniprot id: A0A249SNY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

216427:CK556 RS02905
gene id: 216427:CK556_RS02905
uniprot id: A0A249SNP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS00845
gene id: 216427:CK556_RS00845
uniprot id: A0A249SMJ7
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03600
gene id: 216427:CK556_RS03600
uniprot id: A0A249SP64
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00720
gene id: 216427:CK556_RS00720
uniprot id: A0A249SMR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

216427:CK556 RS01130
gene id: 216427:CK556_RS01130
uniprot id: A0A249SN91
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS03650
gene id: 216427:CK556_RS03650
uniprot id: A0A249SP72
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00645
gene id: 216427:CK556_RS00645
uniprot id: A0A249SMF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

216427:CK556 RS01995
gene id: 216427:CK556_RS01995
uniprot id: A0A249SNE6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

216427:CK556 RS00780
gene id: 216427:CK556_RS00780
uniprot id: A0A249SN29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

216427:CK556 RS00705
gene id: 216427:CK556_RS00705
uniprot id: A0A249SML3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

216427:CK556 RS00425
gene id: 216427:CK556_RS00425
uniprot id: A0A249SMV0
names: Similarity
messages: Belongs to the peptidase M17 family.

216427:CK556 RS00115
gene id: 216427:CK556_RS00115
uniprot id: A0A249SM79
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01920
gene id: 216427:CK556_RS01920
uniprot id: A0A249SNC5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

216427:CK556 RS02815
gene id: 216427:CK556_RS02815
uniprot id: A0A249SNR6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

216427:CK556 RS02790
gene id: 216427:CK556_RS02790
uniprot id: A0A249SNM2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

216427:CK556 RS03715
gene id: 216427:CK556_RS03715
uniprot id: A0A249SP87
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

216427:CK556 RS01275
gene id: 216427:CK556_RS01275
uniprot id: A0A249SMW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

216427:CK556 RS03795
gene id: 216427:CK556_RS03795
uniprot id: A0A249SP71
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

216427:CK556 RS02205
gene id: 216427:CK556_RS02205
uniprot id: A0A249SNV1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

216427:CK556 RS00605
gene id: 216427:CK556_RS00605
uniprot id: A0A249SMJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS02345
gene id: 216427:CK556_RS02345
uniprot id: A0A249SND9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

216427:CK556 RS03240
gene id: 216427:CK556_RS03240
uniprot id: A0A249SNV5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

216427:CK556 RS02675
gene id: 216427:CK556_RS02675
uniprot id: A0A249SNJ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

216427:CK556 RS03055
gene id: 216427:CK556_RS03055
uniprot id: A0A249SNV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

216427:CK556 RS03350
gene id: 216427:CK556_RS03350
uniprot id: A0A249SNX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS02960
gene id: 216427:CK556_RS02960
uniprot id: A0A249SNW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

216427:CK556 RS03010
gene id: 216427:CK556_RS03010
uniprot id: A0A249SNR8
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

216427:CK556 RS02385
gene id: 216427:CK556_RS02385
uniprot id: A0A249SNK3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

216427:CK556 RS00365
gene id: 216427:CK556_RS00365
uniprot id: A0A249SMJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

216427:CK556 RS03645
gene id: 216427:CK556_RS03645
uniprot id: A0A249SPA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216427:CK556 RS01825
gene id: 216427:CK556_RS01825
uniprot id: A0A249SNB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

216427:CK556 RS00545
gene id: 216427:CK556_RS00545
uniprot id: A0A249SMF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS02770
gene id: 216427:CK556_RS02770
uniprot id: A0A249SNS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01600
gene id: 216427:CK556_RS01600
uniprot id: A0A249SN47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

216427:CK556 RS02220
gene id: 216427:CK556_RS02220
uniprot id: A0A249SNB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

216427:CK556 RS01470
gene id: 216427:CK556_RS01470
uniprot id: A0A249SMX3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

216427:CK556 RS01170
gene id: 216427:CK556_RS01170
uniprot id: A0A249SMY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

216427:CK556 RS00070
gene id: 216427:CK556_RS00070
uniprot id: A0A249SM91
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00405
gene id: 216427:CK556_RS00405
uniprot id: A0A249SMK4
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

216427:CK556 RS03290
gene id: 216427:CK556_RS03290
uniprot id: A0A249SNW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS00480
gene id: 216427:CK556_RS00480
uniprot id: A0A249SMK8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS00650
gene id: 216427:CK556_RS00650
uniprot id: A0A249SMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

216427:CK556 RS02195
gene id: 216427:CK556_RS02195
uniprot id: A0A249SNI4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

216427:CK556 RS02425
gene id: 216427:CK556_RS02425
uniprot id: A0A249SNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216427:CK556 RS00085
gene id: 216427:CK556_RS00085
uniprot id: A0A249SME9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS01110
gene id: 216427:CK556_RS01110
uniprot id: A0A249SMX7
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

216427:CK556 RS01355
gene id: 216427:CK556_RS01355
uniprot id: A0A249SN24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

216427:CK556 RS00005
gene id: 216427:CK556_RS00005
uniprot id: A0A249SM30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

216427:CK556 RS01535
gene id: 216427:CK556_RS01535
uniprot id: A0A249SN26
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

216427:CK556 RS00095
gene id: 216427:CK556_RS00095
uniprot id: A0A249SMN8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS00165
gene id: 216427:CK556_RS00165
uniprot id: A0A249SME3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

216427:CK556 RS02700
gene id: 216427:CK556_RS02700
uniprot id: A0A249SNS3
names: Similarity
messages: Belongs to the RNase H family.

216427:CK556 RS02995
gene id: 216427:CK556_RS02995
uniprot id: A0A249SNP8
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216427:CK556 RS02030
gene id: 216427:CK556_RS02030
uniprot id: A0A249SN86
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

216427:CK556 RS00415
gene id: 216427:CK556_RS00415
uniprot id: A0A249SML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

216427:CK556 RS01190
gene id: 216427:CK556_RS01190
uniprot id: A0A249SNA2
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS02680
gene id: 216427:CK556_RS02680
uniprot id: A0A249SNK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS03195
gene id: 216427:CK556_RS03195
uniprot id: A0A249SNU3
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS02810
gene id: 216427:CK556_RS02810
uniprot id: A0A249SNU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

216427:CK556 RS01205
gene id: 216427:CK556_RS01205
uniprot id: A0A249SMY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

216427:CK556 RS03325
gene id: 216427:CK556_RS03325
uniprot id: A0A249SP46
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

216427:CK556 RS02265
gene id: 216427:CK556_RS02265
uniprot id: A0A249SNJ7
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01325
gene id: 216427:CK556_RS01325
uniprot id: A0A249SMX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS00675
gene id: 216427:CK556_RS00675
uniprot id: A0A249SMN6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

216427:CK556 RS00275
gene id: 216427:CK556_RS00275
uniprot id: A0A249SMG2
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

216427:CK556 RS00740
gene id: 216427:CK556_RS00740
uniprot id: A0A249SMQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

216427:CK556 RS01530
gene id: 216427:CK556_RS01530
uniprot id: A0A249SN61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

216427:CK556 RS02730
gene id: 216427:CK556_RS02730
uniprot id: A0A249SNL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS03050
gene id: 216427:CK556_RS03050
uniprot id: A0A249SNU7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

216427:CK556 RS02970
gene id: 216427:CK556_RS02970
uniprot id: A0A249SP76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS03805
gene id: 216427:CK556_RS03805
uniprot id: A0A249SPA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

216427:CK556 RS01455
gene id: 216427:CK556_RS01455
uniprot id: A0A249SN46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS00800
gene id: 216427:CK556_RS00800
uniprot id: A0A249SMK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

216427:CK556 RS00550
gene id: 216427:CK556_RS00550
uniprot id: A0A249SMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

216427:CK556 RS00250
gene id: 216427:CK556_RS00250
uniprot id: A0A249SMF6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS00390
gene id: 216427:CK556_RS00390
uniprot id: A0A249SMA7
names: Similarity
messages: Belongs to the Lgt family.

216427:CK556 RS03375
gene id: 216427:CK556_RS03375
uniprot id: A0A249SP52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

216427:CK556 RS00755
gene id: 216427:CK556_RS00755
uniprot id: A0A249SMM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

216427:CK556 RS00700
gene id: 216427:CK556_RS00700
uniprot id: A0A249SMI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

216427:CK556 RS00795
gene id: 216427:CK556_RS00795
uniprot id: A0A249SMI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS00770
gene id: 216427:CK556_RS00770
uniprot id: A0A249SMT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

216427:CK556 RS00260
gene id: 216427:CK556_RS00260
uniprot id: A0A249SMF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216427:CK556 RS03685
gene id: 216427:CK556_RS03685
uniprot id: A0A249SP73
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

216427:CK556 RS00815
gene id: 216427:CK556_RS00815
uniprot id: A0A249SMS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

216427:CK556 RS01950
gene id: 216427:CK556_RS01950
uniprot id: A0A249SN89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

216427:CK556 RS00210
gene id: 216427:CK556_RS00210
uniprot id: A0A249SPB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS00170
gene id: 216427:CK556_RS00170
uniprot id: A0A249SM65
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS03750
gene id: 216427:CK556_RS03750
uniprot id: A0A249SPC3
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00040
gene id: 216427:CK556_RS00040
uniprot id: A0A249SMM9
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

216427:CK556 RS03190
gene id: 216427:CK556_RS03190
uniprot id: A0A249SNU4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

216427:CK556 RS03435
gene id: 216427:CK556_RS03435
uniprot id: A0A249SP67
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

216427:CK556 RS01840
gene id: 216427:CK556_RS01840
uniprot id: A0A249SN75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

216427:CK556 RS03770
gene id: 216427:CK556_RS03770
uniprot id: A0A249SPC0
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS03070
gene id: 216427:CK556_RS03070
uniprot id: A0A249SNV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

216427:CK556 RS03270
gene id: 216427:CK556_RS03270
uniprot id: A0A249SP03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

216427:CK556 RS00905
gene id: 216427:CK556_RS00905
uniprot id: A0A249SMM5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS00245
gene id: 216427:CK556_RS00245
uniprot id: A0A249SMH4
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01460
gene id: 216427:CK556_RS01460
uniprot id: A0A249SN41
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

216427:CK556 RS00310
gene id: 216427:CK556_RS00310
uniprot id: A0A249SMG4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

216427:CK556 RS03575
gene id: 216427:CK556_RS03575
uniprot id: A0A249SP13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

216427:CK556 RS02175
gene id: 216427:CK556_RS02175
uniprot id: A0A249SNE0
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

216427:CK556 RS03075
gene id: 216427:CK556_RS03075
uniprot id: A0A249SPA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

216427:CK556 RS00295
gene id: 216427:CK556_RS00295
uniprot id: A0A249SMI3
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

216427:CK556 RS01430
gene id: 216427:CK556_RS01430
uniprot id: A0A249SN45
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS02340
gene id: 216427:CK556_RS02340
uniprot id: A0A249SNK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01280
gene id: 216427:CK556_RS01280
uniprot id: A0A249SN13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

216427:CK556 RS00485
gene id: 216427:CK556_RS00485
uniprot id: A0A249SMK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

216427:CK556 RS00600
gene id: 216427:CK556_RS00600
uniprot id: A0A249SMG8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

216427:CK556 RS01450
gene id: 216427:CK556_RS01450
uniprot id: A0A249SNF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

216427:CK556 RS02255
gene id: 216427:CK556_RS02255
uniprot id: A0A249SNW0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216427:CK556 RS01475
gene id: 216427:CK556_RS01475
uniprot id: A0A249SN03
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

216427:CK556 RS01120
gene id: 216427:CK556_RS01120
uniprot id: A0A249SMY5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

216427:CK556 RS03280
gene id: 216427:CK556_RS03280
uniprot id: A0A249SP15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

216427:CK556 RS01495
gene id: 216427:CK556_RS01495
uniprot id: A0A249SN34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216427:CK556 RS00695
gene id: 216427:CK556_RS00695
uniprot id: A0A249SMG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

216427:CK556 RS00190
gene id: 216427:CK556_RS00190
uniprot id: A0A249SMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS03460
gene id: 216427:CK556_RS03460
uniprot id: A0A249SP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

216427:CK556 RS03840
gene id: 216427:CK556_RS03840
uniprot id: A0A249SPS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

216427:CK556 RS03005
gene id: 216427:CK556_RS03005
uniprot id: A0A249SNU9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

216427:CK556 RS02350
gene id: 216427:CK556_RS02350
uniprot id: A0A249SNE2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

216427:CK556 RS03845
gene id: 216427:CK556_RS03845
uniprot id: A0A249SPA3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

216427:CK556 RS01435
gene id: 216427:CK556_RS01435
uniprot id: A0A249SN15
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00745
gene id: 216427:CK556_RS00745
uniprot id: A0A249SMH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

216427:CK556 RS03615
gene id: 216427:CK556_RS03615
uniprot id: A0A249SP90
names: Cofactor
messages: Binds 1 zinc ion per subunit.

216427:CK556 RS00385
gene id: 216427:CK556_RS00385
uniprot id: A0A249SMI2
names: Similarity
messages: Belongs to the HPrK/P family.

216427:CK556 RS01835
gene id: 216427:CK556_RS01835
uniprot id: A0A249SN44
names: Similarity
messages: Belongs to the XseB family.

216427:CK556 RS00155
gene id: 216427:CK556_RS00155
uniprot id: A0A249SMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS02805
gene id: 216427:CK556_RS02805
uniprot id: A0A249SNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

216427:CK556 RS02300
gene id: 216427:CK556_RS02300
uniprot id: A0A249SNG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

216427:CK556 RS01090
gene id: 216427:CK556_RS01090
uniprot id: A0A249SMW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

216427:CK556 RS00575
gene id: 216427:CK556_RS00575
uniprot id: A0A249SMX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

216427:CK556 RS03165
gene id: 216427:CK556_RS03165
uniprot id: A0A249SP01
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

216427:CK556 RS01830
gene id: 216427:CK556_RS01830
uniprot id: A0A249SN50
names: Similarity
messages: Belongs to the TlyA family.

216427:CK556 RS00035
gene id: 216427:CK556_RS00035
uniprot id: A0A249SMB3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

216427:CK556 RS02495
gene id: 216427:CK556_RS02495
uniprot id: A0A249SNP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

216427:CK556 RS01165
gene id: 216427:CK556_RS01165
uniprot id: A0A249SMU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

216427:CK556 RS01150
gene id: 216427:CK556_RS01150
uniprot id: A0A249SMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

216427:CK556 RS00520
gene id: 216427:CK556_RS00520
uniprot id: A0A249SMK1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

216427:CK556 RS03660
gene id: 216427:CK556_RS03660
uniprot id: A0A249SP78
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

216427:CK556 RS01595
gene id: 216427:CK556_RS01595
uniprot id: A0A249SN74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

216427:CK556 RS01560
gene id: 216427:CK556_RS01560
uniprot id: A0A249SN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

216427:CK556 RS02055
gene id: 216427:CK556_RS02055
uniprot id: A0A249SNG2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

216427:CK556 RS03515
gene id: 216427:CK556_RS03515
uniprot id: A0A249SNZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

216427:CK556 RS03380
gene id: 216427:CK556_RS03380
uniprot id: A0A249SP20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

216427:CK556 RS00450
gene id: 216427:CK556_RS00450
uniprot id: A0A249SMG3
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

216427:CK556 RS00400
gene id: 216427:CK556_RS00400
uniprot id: A0A249SMF2
names: Similarity
messages: Belongs to the Lgt family.

216427:CK556 RS02420
gene id: 216427:CK556_RS02420
uniprot id: A0A249SNM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

216427:CK556 RS00430
gene id: 216427:CK556_RS00430
uniprot id: A0A249SMK0
names: Similarity
messages: Belongs to the peptidase M17 family.

216427:CK556 RS02235
gene id: 216427:CK556_RS02235
uniprot id: A0A249SNH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

216427:CK556 RS03390
gene id: 216427:CK556_RS03390
uniprot id: A0A249SP33
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01500
gene id: 216427:CK556_RS01500
uniprot id: A0A249SNG3
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00360
gene id: 216427:CK556_RS00360
uniprot id: A0A249SMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

216427:CK556 RS02095
gene id: 216427:CK556_RS02095
uniprot id: A0A249SNG4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

216427:CK556 RS03725
gene id: 216427:CK556_RS03725
uniprot id: A0A249SP36
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00530
gene id: 216427:CK556_RS00530
uniprot id: A0A249SML8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

216427:CK556 RS02925
gene id: 216427:CK556_RS02925
uniprot id: A0A249SNU6
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

216427:CK556 RS00030
gene id: 216427:CK556_RS00030
uniprot id: A0A249SME0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

216427:CK556 RS00635
gene id: 216427:CK556_RS00635
uniprot id: A0A249SMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

216427:CK556 RS01350
gene id: 216427:CK556_RS01350
uniprot id: A0A249SND3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

216427:CK556 RS00220
gene id: 216427:CK556_RS00220
uniprot id: A0A249SMG1
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01675
gene id: 216427:CK556_RS01675
uniprot id: A0A249SN14
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

216427:CK556 RS02900
gene id: 216427:CK556_RS02900
uniprot id: A0A249SNT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS02695
gene id: 216427:CK556_RS02695
uniprot id: A0A249SNL9
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

216427:CK556 RS00225
gene id: 216427:CK556_RS00225
uniprot id: A0A249SMF4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS01310
gene id: 216427:CK556_RS01310
uniprot id: A0A249SN05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216427:CK556 RS01345
gene id: 216427:CK556_RS01345
uniprot id: A0A249SN12
names: Similarity
messages: Belongs to the peptidase M13 family.

216427:CK556 RS03635
gene id: 216427:CK556_RS03635
uniprot id: A0A249SP69
names: Similarity
messages: Belongs to the RpoE family.

216427:CK556 RS02360
gene id: 216427:CK556_RS02360
uniprot id: A0A249SNJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

216427:CK556 RS00150
gene id: 216427:CK556_RS00150
uniprot id: A0A249SMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

216427:CK556 RS01505
gene id: 216427:CK556_RS01505
uniprot id: A0A249SN52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS00805
gene id: 216427:CK556_RS00805
uniprot id: A0A249SMN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

216427:CK556 RS02660
gene id: 216427:CK556_RS02660
uniprot id: A0A249SP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

216427:CK556 RS00995
gene id: 216427:CK556_RS00995
uniprot id: A0A249SML9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01230
gene id: 216427:CK556_RS01230
uniprot id: A0A249SMY4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

216427:CK556 RS00495
gene id: 216427:CK556_RS00495
uniprot id: A0A249SME6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

216427:CK556 RS00630
gene id: 216427:CK556_RS00630
uniprot id: A0A249SMY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

216427:CK556 RS03140
gene id: 216427:CK556_RS03140
uniprot id: A0A249SNS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

216427:CK556 RS01465
gene id: 216427:CK556_RS01465
uniprot id: A0A249SMW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS01295
gene id: 216427:CK556_RS01295
uniprot id: A0A249SMZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

216427:CK556 RS00825
gene id: 216427:CK556_RS00825
uniprot id: A0A249SMS2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

216427:CK556 RS01030
gene id: 216427:CK556_RS01030
uniprot id: A0A249SN71
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS03060
gene id: 216427:CK556_RS03060
uniprot id: A0A249SNS7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

216427:CK556 RS03040
gene id: 216427:CK556_RS03040
uniprot id: A0A249SNQ7
names: Similarity
messages: Belongs to the DprA/Smf family.

216427:CK556 RS02230
gene id: 216427:CK556_RS02230
uniprot id: A0A249SNE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

216427:CK556 RS03570
gene id: 216427:CK556_RS03570
uniprot id: A0A249SP10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

216427:CK556 RS03150
gene id: 216427:CK556_RS03150
uniprot id: A0A249SNW8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS02720
gene id: 216427:CK556_RS02720
uniprot id: A0A249SNR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

216427:CK556 RS00750
gene id: 216427:CK556_RS00750
uniprot id: A0A249SMJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

216427:CK556 RS00570
gene id: 216427:CK556_RS00570
uniprot id: A0A249SML0
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

216427:CK556 RS03355
gene id: 216427:CK556_RS03355
uniprot id: A0A249SNX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

216427:CK556 RS00075
gene id: 216427:CK556_RS00075
uniprot id: A0A249SME5
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

216427:CK556 RS01905
gene id: 216427:CK556_RS01905
uniprot id: A0A249SND4
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS01155
gene id: 216427:CK556_RS01155
uniprot id: A0A249SMQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

216427:CK556 RS03780
gene id: 216427:CK556_RS03780
uniprot id: A0A249SP44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

216427:CK556 RS01055
gene id: 216427:CK556_RS01055
uniprot id: A0A249SMR6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

216427:CK556 RS02240
gene id: 216427:CK556_RS02240
uniprot id: A0A249SNE1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

216427:CK556 RS00585
gene id: 216427:CK556_RS00585
uniprot id: A0A249SMM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

216427:CK556 RS01390
gene id: 216427:CK556_RS01390
uniprot id: A0A249SN36
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

216427:CK556 RS00010
gene id: 216427:CK556_RS00010
uniprot id: A0A249SM59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

216427:CK556 RS00130
gene id: 216427:CK556_RS00130
uniprot id: A0A249SMF5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01060
gene id: 216427:CK556_RS01060
uniprot id: A0A249SMW6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

216427:CK556 RS02045
gene id: 216427:CK556_RS02045
uniprot id: A0A249SNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

216427:CK556 RS03700
gene id: 216427:CK556_RS03700
uniprot id: A0A249SPB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

216427:CK556 RS02965
gene id: 216427:CK556_RS02965
uniprot id: A0A249SNT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

216427:CK556 RS03260
gene id: 216427:CK556_RS03260
uniprot id: A0A249SNX2
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

216427:CK556 RS00105
gene id: 216427:CK556_RS00105
uniprot id: A0A249SMD3
names: Subcellular Location Annotation
messages: Membrane

216427:CK556 RS00810
gene id: 216427:CK556_RS00810
uniprot id: A0A249SMT0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

216427:CK556 RS02375
gene id: 216427:CK556_RS02375
uniprot id: A0A249SNJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS01265
gene id: 216427:CK556_RS01265
uniprot id: A0A249SMR8
names: Similarity
messages: Belongs to the asp23 family.

216427:CK556 RS02705
gene id: 216427:CK556_RS02705
uniprot id: A0A249SNP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

216427:CK556 RS00110
gene id: 216427:CK556_RS00110
uniprot id: A0A249SM56
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216427:CK556 RS02380
gene id: 216427:CK556_RS02380
uniprot id: A0A249SNX8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.