213810:RUM RS10035
gene id: 213810:RUM_RS10035
uniprot id: D4LEP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS03680
gene id: 213810:RUM_RS03680
uniprot id: D4LBG2
names: Subcellular Location Annotation
messages: Cell membrane

213810:RUM RS09355
gene id: 213810:RUM_RS09355
uniprot id: D4LEC3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

213810:RUM RS02735
gene id: 213810:RUM_RS02735
uniprot id: D4LAZ1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

213810:RUM RS00940
gene id: 213810:RUM_RS00940
uniprot id: D4LA07
names: Similarity
messages: Belongs to the ABC transporter superfamily.

213810:RUM RS00300
gene id: 213810:RUM_RS00300
uniprot id: D4L9P5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

213810:RUM RS04165
gene id: 213810:RUM_RS04165
uniprot id: D4LBP5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

213810:RUM RS06910
gene id: 213810:RUM_RS06910
uniprot id: D4LD35
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

213810:RUM RS04675
gene id: 213810:RUM_RS04675
uniprot id: D4LBZ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

213810:RUM RS04020
gene id: 213810:RUM_RS04020
uniprot id: D4LBL9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

213810:RUM RS09590
gene id: 213810:RUM_RS09590
uniprot id: D4LEG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

213810:RUM RS04645
gene id: 213810:RUM_RS04645
uniprot id: D4LBZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

213810:RUM RS10555
gene id: 213810:RUM_RS10555
uniprot id: D4LEZ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

213810:RUM RS10775
gene id: 213810:RUM_RS10775
uniprot id: D4LF33
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

213810:RUM RS07050
gene id: 213810:RUM_RS07050
uniprot id: D4LD62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

213810:RUM RS09635
gene id: 213810:RUM_RS09635
uniprot id: D4LEH4
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

213810:RUM RS10740
gene id: 213810:RUM_RS10740
uniprot id: D4LF28
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

213810:RUM RS09565
gene id: 213810:RUM_RS09565
uniprot id: D4LEG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

213810:RUM RS07335
gene id: 213810:RUM_RS07335
uniprot id: D4LDA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07315
gene id: 213810:RUM_RS07315
uniprot id: D4LDA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

213810:RUM RS00470
gene id: 213810:RUM_RS00470
uniprot id: D4L9S2
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS03445
gene id: 213810:RUM_RS03445
uniprot id: D4LBB9
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

213810:RUM RS07705
gene id: 213810:RUM_RS07705
uniprot id: D4LDH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

213810:RUM RS07355
gene id: 213810:RUM_RS07355
uniprot id: D4LDB0
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.

213810:RUM RS11265
gene id: 213810:RUM_RS11265
uniprot id: D4LFB4
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS06365
gene id: 213810:RUM_RS06365
uniprot id: D4LCU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

213810:RUM RS02955
gene id: 213810:RUM_RS02955
uniprot id: D4LB35
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS06135
gene id: 213810:RUM_RS06135
uniprot id: D4LCQ6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

213810:RUM RS00120
gene id: 213810:RUM_RS00120
uniprot id: D4L9L3
names: Similarity
messages: Belongs to the peptidase C1 family.

213810:RUM RS02135
gene id: 213810:RUM_RS02135
uniprot id: D4LAM7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

213810:RUM RS10395
gene id: 213810:RUM_RS10395
uniprot id: D4LEW4
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

213810:RUM RS06480
gene id: 213810:RUM_RS06480
uniprot id: D4LCW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

213810:RUM RS10485
gene id: 213810:RUM_RS10485
uniprot id: D4LEY2
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10385
gene id: 213810:RUM_RS10385
uniprot id: D4LEW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

213810:RUM RS11205
gene id: 213810:RUM_RS11205
uniprot id: D4LFA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

213810:RUM RS05460
gene id: 213810:RUM_RS05460
uniprot id: D4LCE1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

213810:RUM RS02920
gene id: 213810:RUM_RS02920
uniprot id: D4LB28
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

213810:RUM RS01685
gene id: 213810:RUM_RS01685
uniprot id: D4LAE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

213810:RUM RS05170
gene id: 213810:RUM_RS05170
uniprot id: D4LC86
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

213810:RUM RS01415
gene id: 213810:RUM_RS01415
uniprot id: D4LA93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

213810:RUM RS03720
gene id: 213810:RUM_RS03720
uniprot id: D4LBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

213810:RUM RS09210
gene id: 213810:RUM_RS09210
uniprot id: D4LE98
names: Similarity
messages: Belongs to the asp23 family.

213810:RUM RS11280
gene id: 213810:RUM_RS11280
uniprot id: D4LFB7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

213810:RUM RS02960
gene id: 213810:RUM_RS02960
uniprot id: D4LB36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS02885
gene id: 213810:RUM_RS02885
uniprot id: D4LB21
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS10680
gene id: 213810:RUM_RS10680
uniprot id: D4LF18
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

213810:RUM RS06880
gene id: 213810:RUM_RS06880
uniprot id: D4LD30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

213810:RUM RS02090
gene id: 213810:RUM_RS02090
uniprot id: D4LAL9
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

213810:RUM RS02595
gene id: 213810:RUM_RS02595
uniprot id: D4LAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

213810:RUM RS10705
gene id: 213810:RUM_RS10705
uniprot id: D4LF23
names: Similarity
messages: Belongs to the thioesterase family.

213810:RUM RS00960
gene id: 213810:RUM_RS00960
uniprot id: D4LA12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS01900
gene id: 213810:RUM_RS01900
uniprot id: D4LAI2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS08075
gene id: 213810:RUM_RS08075
uniprot id: D4LDP4
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

213810:RUM RS02025
gene id: 213810:RUM_RS02025
uniprot id: D4LAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

213810:RUM RS07345
gene id: 213810:RUM_RS07345
uniprot id: D4LDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

213810:RUM RS01080
gene id: 213810:RUM_RS01080
uniprot id: D4LA32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

213810:RUM RS01430
gene id: 213810:RUM_RS01430
uniprot id: D4LA95
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS03765
gene id: 213810:RUM_RS03765
uniprot id: D4LBH8
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS08960
gene id: 213810:RUM_RS08960
uniprot id: D4LE53
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

213810:RUM RS03230
gene id: 213810:RUM_RS03230
uniprot id: D4LB84
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

213810:RUM RS01265
gene id: 213810:RUM_RS01265
uniprot id: D4LA66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

213810:RUM RS07200
gene id: 213810:RUM_RS07200
uniprot id: D4LD85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

213810:RUM RS07850
gene id: 213810:RUM_RS07850
uniprot id: D4LDK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

213810:RUM RS03015
gene id: 213810:RUM_RS03015
uniprot id: D4LB46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

213810:RUM RS00180
gene id: 213810:RUM_RS00180
uniprot id: D4L9M5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS11640
gene id: 213810:RUM_RS11640
uniprot id: D4LFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

213810:RUM RS04945
gene id: 213810:RUM_RS04945
uniprot id: D4LC46
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

213810:RUM RS07325
gene id: 213810:RUM_RS07325
uniprot id: D4LDA4
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS02765
gene id: 213810:RUM_RS02765
uniprot id: D4LAZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

213810:RUM RS07220
gene id: 213810:RUM_RS07220
uniprot id: D4LD89
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

213810:RUM RS05450
gene id: 213810:RUM_RS05450
uniprot id: D4LCD8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

213810:RUM RS07210
gene id: 213810:RUM_RS07210
uniprot id: D4LD87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

213810:RUM RS07145
gene id: 213810:RUM_RS07145
uniprot id: D4LD77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

213810:RUM RS04305
gene id: 213810:RUM_RS04305
uniprot id: D4LBS3
names: Subcellular Location Annotation
messages: Cytoplasm

213810:RUM RS10815
gene id: 213810:RUM_RS10815
uniprot id: D4LF38
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

213810:RUM RS11025
gene id: 213810:RUM_RS11025
uniprot id: D4LF73
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

213810:RUM RS11410
gene id: 213810:RUM_RS11410
uniprot id: D4LFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

213810:RUM RS01960
gene id: 213810:RUM_RS01960
uniprot id: D4LAJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

213810:RUM RS05815
gene id: 213810:RUM_RS05815
uniprot id: D4LCK0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

213810:RUM RS03005
gene id: 213810:RUM_RS03005
uniprot id: D4LB44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS06035
gene id: 213810:RUM_RS06035
uniprot id: D4LCP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

213810:RUM RS11490
gene id: 213810:RUM_RS11490
uniprot id: D4LFF8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

213810:RUM RS04235
gene id: 213810:RUM_RS04235
uniprot id: D4LBQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

213810:RUM RS08140
gene id: 213810:RUM_RS08140
uniprot id: D4LDQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

213810:RUM RS08920
gene id: 213810:RUM_RS08920
uniprot id: D4LE47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS04375
gene id: 213810:RUM_RS04375
uniprot id: D4LBT7
names: Similarity
messages: Belongs to the TrpF family.

213810:RUM RS11335
gene id: 213810:RUM_RS11335
uniprot id: D4LFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

213810:RUM RS01725
gene id: 213810:RUM_RS01725
uniprot id: D4LAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

213810:RUM RS04140
gene id: 213810:RUM_RS04140
uniprot id: D4LBP1
names: Similarity
messages: Belongs to the UPF0102 family.

213810:RUM RS08925
gene id: 213810:RUM_RS08925
uniprot id: D4LE48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

213810:RUM RS07165
gene id: 213810:RUM_RS07165
uniprot id: D4LD81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

213810:RUM RS10460
gene id: 213810:RUM_RS10460
uniprot id: D4LEX7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

213810:RUM RS07450
gene id: 213810:RUM_RS07450
uniprot id: D4LDC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

213810:RUM RS07400
gene id: 213810:RUM_RS07400
uniprot id: D4LDB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

213810:RUM RS06715
gene id: 213810:RUM_RS06715
uniprot id: D4LD01
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

213810:RUM RS05875
gene id: 213810:RUM_RS05875
uniprot id: D4LCL1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

213810:RUM RS01600
gene id: 213810:RUM_RS01600
uniprot id: D4LAC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS06470
gene id: 213810:RUM_RS06470
uniprot id: D4LCW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

213810:RUM RS10710
gene id: 213810:RUM_RS10710
uniprot id: D4LF24
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

213810:RUM RS02945
gene id: 213810:RUM_RS02945
uniprot id: D4LB33
names: Similarity
messages: Belongs to the transpeptidase family.

213810:RUM RS04765
gene id: 213810:RUM_RS04765
uniprot id: D4LC13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

213810:RUM RS06070
gene id: 213810:RUM_RS06070
uniprot id: D4LCP4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

213810:RUM RS09745
gene id: 213810:RUM_RS09745
uniprot id: D4LEJ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

213810:RUM RS03110
gene id: 213810:RUM_RS03110
uniprot id: D4LB63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

213810:RUM RS09845
gene id: 213810:RUM_RS09845
uniprot id: D4LEL2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS06355
gene id: 213810:RUM_RS06355
uniprot id: D4LCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Membrane

213810:RUM RS02100
gene id: 213810:RUM_RS02100
uniprot id: D4LAM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

213810:RUM RS01905
gene id: 213810:RUM_RS01905
uniprot id: D4LAI3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

213810:RUM RS02530
gene id: 213810:RUM_RS02530
uniprot id: D4LAV1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS02050
gene id: 213810:RUM_RS02050
uniprot id: D4LAL2
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS01675
gene id: 213810:RUM_RS01675
uniprot id: D4LAE1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

213810:RUM RS06435
gene id: 213810:RUM_RS06435
uniprot id: D4LCV6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

213810:RUM RS11285
gene id: 213810:RUM_RS11285
uniprot id: D4LFB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

213810:RUM RS06255
gene id: 213810:RUM_RS06255
uniprot id: D4LCS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

213810:RUM RS02570
gene id: 213810:RUM_RS02570
uniprot id: D4LAV8
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04030
gene id: 213810:RUM_RS04030
uniprot id: D4LBM1
names: Similarity
messages: Belongs to the RemA family.

213810:RUM RS01810
gene id: 213810:RUM_RS01810
uniprot id: D4LAG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

213810:RUM RS07905
gene id: 213810:RUM_RS07905
uniprot id: D4LDL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

213810:RUM RS02290
gene id: 213810:RUM_RS02290
uniprot id: D4LAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

213810:RUM RS07330
gene id: 213810:RUM_RS07330
uniprot id: D4LDA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS00975
gene id: 213810:RUM_RS00975
uniprot id: D4LA14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

213810:RUM RS04240
gene id: 213810:RUM_RS04240
uniprot id: D4LBQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS01480
gene id: 213810:RUM_RS01480
uniprot id: D4LAA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS11380
gene id: 213810:RUM_RS11380
uniprot id: D4LFD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS04680
gene id: 213810:RUM_RS04680
uniprot id: D4LBZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

213810:RUM RS04875
gene id: 213810:RUM_RS04875
uniprot id: D4LC34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

213810:RUM RS10885
gene id: 213810:RUM_RS10885
uniprot id: D4LF51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

213810:RUM RS03635
gene id: 213810:RUM_RS03635
uniprot id: D4LBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

213810:RUM RS00330
gene id: 213810:RUM_RS00330
uniprot id: D4L9P8
names: Similarity
messages: Belongs to the thioesterase family.

213810:RUM RS04665
gene id: 213810:RUM_RS04665
uniprot id: D4LBZ6
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

213810:RUM RS03515
gene id: 213810:RUM_RS03515
uniprot id: D4LBD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

213810:RUM RS00605
gene id: 213810:RUM_RS00605
uniprot id: D4L9U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

213810:RUM RS07385
gene id: 213810:RUM_RS07385
uniprot id: D4LDB6
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

213810:RUM RS01865
gene id: 213810:RUM_RS01865
uniprot id: D4LAH5
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS03875
gene id: 213810:RUM_RS03875
uniprot id: D4LBJ4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

213810:RUM RS03505
gene id: 213810:RUM_RS03505
uniprot id: D4LBD1
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS09255
gene id: 213810:RUM_RS09255
uniprot id: D4LEA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS02275
gene id: 213810:RUM_RS02275
uniprot id: D4LAQ5
names: Similarity
messages: Belongs to the asparagine synthetase family.

213810:RUM RS02935
gene id: 213810:RUM_RS02935
uniprot id: D4LB31
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

213810:RUM RS09585
gene id: 213810:RUM_RS09585
uniprot id: D4LEG5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS10425
gene id: 213810:RUM_RS10425
uniprot id: D4LEW9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

213810:RUM RS06780
gene id: 213810:RUM_RS06780
uniprot id: D4LD11
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS03745
gene id: 213810:RUM_RS03745
uniprot id: D4LBH5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

213810:RUM RS10970
gene id: 213810:RUM_RS10970
uniprot id: D4LF61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

213810:RUM RS00265
gene id: 213810:RUM_RS00265
uniprot id: D4L9P2
names: Similarity
messages: Belongs to the IMPACT family.

213810:RUM RS11290
gene id: 213810:RUM_RS11290
uniprot id: D4LFB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

213810:RUM RS05430
gene id: 213810:RUM_RS05430
uniprot id: D4LCD4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

213810:RUM RS08145
gene id: 213810:RUM_RS08145
uniprot id: D4LDQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

213810:RUM RS00130
gene id: 213810:RUM_RS00130
uniprot id: D4L9L5
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

213810:RUM RS07170
gene id: 213810:RUM_RS07170
uniprot id: D4LD82
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

213810:RUM RS01885
gene id: 213810:RUM_RS01885
uniprot id: D4LAH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

213810:RUM RS11925
gene id: 213810:RUM_RS11925
uniprot id: D4LB72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

213810:RUM RS00525
gene id: 213810:RUM_RS00525
uniprot id: D4L9T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

213810:RUM RS04295
gene id: 213810:RUM_RS04295
uniprot id: D4LBS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

213810:RUM RS03690
gene id: 213810:RUM_RS03690
uniprot id: D4LBG4
names: Similarity
messages: Belongs to the UPF0178 family.

213810:RUM RS00990
gene id: 213810:RUM_RS00990
uniprot id: D4LA17
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

213810:RUM RS12930
gene id: 213810:RUM_RS12930
uniprot id: D4LFF2
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

213810:RUM RS08980
gene id: 213810:RUM_RS08980
uniprot id: D4LE57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS03180
gene id: 213810:RUM_RS03180
uniprot id: D4LB77
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

213810:RUM RS03525
gene id: 213810:RUM_RS03525
uniprot id: D4LBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

213810:RUM RS08790
gene id: 213810:RUM_RS08790
uniprot id: D4LE21
names: Similarity
messages: Belongs to the SfsA family.

213810:RUM RS09070
gene id: 213810:RUM_RS09070
uniprot id: D4LE69
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS06185
gene id: 213810:RUM_RS06185
uniprot id: D4LCR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

213810:RUM RS06595
gene id: 213810:RUM_RS06595
uniprot id: D4LCY4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

213810:RUM RS09455
gene id: 213810:RUM_RS09455
uniprot id: D4LEE0
names: Similarity
messages: Belongs to the MecA family.

213810:RUM RS04985
gene id: 213810:RUM_RS04985
uniprot id: D4LC53
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

213810:RUM RS01455
gene id: 213810:RUM_RS01455
uniprot id: D4LAA0
names: Similarity
messages: Belongs to the ParB family.

213810:RUM RS09045
gene id: 213810:RUM_RS09045
uniprot id: D4LE64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

213810:RUM RS11445
gene id: 213810:RUM_RS11445
uniprot id: D4LFF0
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

213810:RUM RS01915
gene id: 213810:RUM_RS01915
uniprot id: D4LAI5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS10040
gene id: 213810:RUM_RS10040
uniprot id: D4LEP8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS00055
gene id: 213810:RUM_RS00055
uniprot id: D4L9K4
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04610
gene id: 213810:RUM_RS04610
uniprot id: D4LBY5
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04655
gene id: 213810:RUM_RS04655
uniprot id: D4LBZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

213810:RUM RS01655
gene id: 213810:RUM_RS01655
uniprot id: D4LAD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

213810:RUM RS13145
gene id: 213810:RUM_RS13145
uniprot id: D4L9Z4
names: Subcellular Location Annotation
messages: Secreted

213810:RUM RS07535
gene id: 213810:RUM_RS07535
uniprot id: D4LDE5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

213810:RUM RS06115
gene id: 213810:RUM_RS06115
uniprot id: D4LCQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

213810:RUM RS02380
gene id: 213810:RUM_RS02380
uniprot id: D4LAS5
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS09470
gene id: 213810:RUM_RS09470
uniprot id: D4LEE2
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

213810:RUM RS11460
gene id: 213810:RUM_RS11460
uniprot id: D4LFF3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

213810:RUM RS10270
gene id: 213810:RUM_RS10270
uniprot id: D4LEU0
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

213810:RUM RS06140
gene id: 213810:RUM_RS06140
uniprot id: D4LCQ7
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10085
gene id: 213810:RUM_RS10085
uniprot id: D4LEQ7
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04785
gene id: 213810:RUM_RS04785
uniprot id: D4LC18
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

213810:RUM RS01200
gene id: 213810:RUM_RS01200
uniprot id: D4LA53
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

213810:RUM RS03205
gene id: 213810:RUM_RS03205
uniprot id: D4LB81
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

213810:RUM RS03545
gene id: 213810:RUM_RS03545
uniprot id: D4LBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

213810:RUM RS04575
gene id: 213810:RUM_RS04575
uniprot id: D4LBX9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

213810:RUM RS04280
gene id: 213810:RUM_RS04280
uniprot id: D4LBR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

213810:RUM RS05265
gene id: 213810:RUM_RS05265
uniprot id: D4LCA6
names: Similarity
messages: Belongs to the HdrA family.

213810:RUM RS01425
gene id: 213810:RUM_RS01425
uniprot id: D4LA94
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS04120
gene id: 213810:RUM_RS04120
uniprot id: D4LBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS01320
gene id: 213810:RUM_RS01320
uniprot id: D4LA75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

213810:RUM RS02995
gene id: 213810:RUM_RS02995
uniprot id: D4LB42
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

213810:RUM RS05915
gene id: 213810:RUM_RS05915
uniprot id: D4LCL8
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS06895
gene id: 213810:RUM_RS06895
uniprot id: D4LD33
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

213810:RUM RS11440
gene id: 213810:RUM_RS11440
uniprot id: D4LFE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

213810:RUM RS06260
gene id: 213810:RUM_RS06260
uniprot id: D4LCS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

213810:RUM RS11975
gene id: 213810:RUM_RS11975
uniprot id: D4LBH6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

213810:RUM RS00255
gene id: 213810:RUM_RS00255
uniprot id: D4L9P0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

213810:RUM RS02555
gene id: 213810:RUM_RS02555
uniprot id: D4LAV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

213810:RUM RS09140
gene id: 213810:RUM_RS09140
uniprot id: D4LE83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

213810:RUM RS11465
gene id: 213810:RUM_RS11465
uniprot id: D4LFF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

213810:RUM RS04385
gene id: 213810:RUM_RS04385
uniprot id: D4LBT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

213810:RUM RS03740
gene id: 213810:RUM_RS03740
uniprot id: D4LBH4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

213810:RUM RS02785
gene id: 213810:RUM_RS02785
uniprot id: D4LB01
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

213810:RUM RS02465
gene id: 213810:RUM_RS02465
uniprot id: D4LAT9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS01565
gene id: 213810:RUM_RS01565
uniprot id: D4LAB8
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

213810:RUM RS09510
gene id: 213810:RUM_RS09510
uniprot id: D4LEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

213810:RUM RS10345
gene id: 213810:RUM_RS10345
uniprot id: D4LEV5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS02505
gene id: 213810:RUM_RS02505
uniprot id: D4LAU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

213810:RUM RS10065
gene id: 213810:RUM_RS10065
uniprot id: D4LEQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

213810:RUM RS07270
gene id: 213810:RUM_RS07270
uniprot id: D4LD97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

213810:RUM RS00125
gene id: 213810:RUM_RS00125
uniprot id: D4L9L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS03000
gene id: 213810:RUM_RS03000
uniprot id: D4LB43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

213810:RUM RS01010
gene id: 213810:RUM_RS01010
uniprot id: D4LA21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

213810:RUM RS10570
gene id: 213810:RUM_RS10570
uniprot id: D4LEZ8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.

213810:RUM RS00575
gene id: 213810:RUM_RS00575
uniprot id: D4L9U1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: In the N-terminal section; belongs to the DHNA family.

213810:RUM RS02990
gene id: 213810:RUM_RS02990
uniprot id: D4LB41
names: Similarity
messages: Belongs to the UPF0237 family.

213810:RUM RS04670
gene id: 213810:RUM_RS04670
uniprot id: D4LBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

213810:RUM RS01255
gene id: 213810:RUM_RS01255
uniprot id: D4LA64
names: Caution
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

213810:RUM RS05380
gene id: 213810:RUM_RS05380
uniprot id: D4LCC6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

213810:RUM RS04865
gene id: 213810:RUM_RS04865
uniprot id: D4LC32
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

213810:RUM RS11855
gene id: 213810:RUM_RS11855
uniprot id: D4LA78
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS04890
gene id: 213810:RUM_RS04890
uniprot id: D4LC37
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

213810:RUM RS05835
gene id: 213810:RUM_RS05835
uniprot id: D4LCK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

213810:RUM RS10350
gene id: 213810:RUM_RS10350
uniprot id: D4LEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

213810:RUM RS09100
gene id: 213810:RUM_RS09100
uniprot id: D4LE75
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

213810:RUM RS07055
gene id: 213810:RUM_RS07055
uniprot id: D4LD63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

213810:RUM RS01105
gene id: 213810:RUM_RS01105
uniprot id: D4LA37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

213810:RUM RS07465
gene id: 213810:RUM_RS07465
uniprot id: D4LDD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS09530
gene id: 213810:RUM_RS09530
uniprot id: D4LEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

213810:RUM RS05285
gene id: 213810:RUM_RS05285
uniprot id: D4LCB0
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

213810:RUM RS11700
gene id: 213810:RUM_RS11700
uniprot id: D4LFJ8
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

213810:RUM RS09445
gene id: 213810:RUM_RS09445
uniprot id: D4LED9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04760
gene id: 213810:RUM_RS04760
uniprot id: D4LC12
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

213810:RUM RS10765
gene id: 213810:RUM_RS10765
uniprot id: D4LF32
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

213810:RUM RS05425
gene id: 213810:RUM_RS05425
uniprot id: D4LCD3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

213810:RUM RS10490
gene id: 213810:RUM_RS10490
uniprot id: D4LEY3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07425
gene id: 213810:RUM_RS07425
uniprot id: D4LDC4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

213810:RUM RS00310
gene id: 213810:RUM_RS00310
uniprot id: D4L9P7
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

213810:RUM RS07240
gene id: 213810:RUM_RS07240
uniprot id: D4LD93
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

213810:RUM RS10685
gene id: 213810:RUM_RS10685
uniprot id: D4LF19
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

213810:RUM RS02175
gene id: 213810:RUM_RS02175
uniprot id: D4LAN5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

213810:RUM RS03490
gene id: 213810:RUM_RS03490
uniprot id: D4LBC8
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04135
gene id: 213810:RUM_RS04135
uniprot id: D4LBP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

213810:RUM RS01315
gene id: 213810:RUM_RS01315
uniprot id: D4LA74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

213810:RUM RS07475
gene id: 213810:RUM_RS07475
uniprot id: D4LDD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

213810:RUM RS04155
gene id: 213810:RUM_RS04155
uniprot id: D4LBP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

213810:RUM RS07570
gene id: 213810:RUM_RS07570
uniprot id: D4LDF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

213810:RUM RS02350
gene id: 213810:RUM_RS02350
uniprot id: D4LAS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

213810:RUM RS01295
gene id: 213810:RUM_RS01295
uniprot id: D4LA70
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

213810:RUM RS04815
gene id: 213810:RUM_RS04815
uniprot id: D4LC24
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11130
gene id: 213810:RUM_RS11130
uniprot id: D4LF92
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04005
gene id: 213810:RUM_RS04005
uniprot id: D4LBL8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

213810:RUM RS04905
gene id: 213810:RUM_RS04905
uniprot id: D4LC39
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS08175
gene id: 213810:RUM_RS08175
uniprot id: D4LDR3
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

213810:RUM RS04695
gene id: 213810:RUM_RS04695
uniprot id: D4LC01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS09230
gene id: 213810:RUM_RS09230
uniprot id: D4LEA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

213810:RUM RS01225
gene id: 213810:RUM_RS01225
uniprot id: D4LA58
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

213810:RUM RS01580
gene id: 213810:RUM_RS01580
uniprot id: D4LAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

213810:RUM RS06250
gene id: 213810:RUM_RS06250
uniprot id: D4LCS3
names: Similarity
messages: Belongs to the DprA/Smf family.

213810:RUM RS02035
gene id: 213810:RUM_RS02035
uniprot id: D4LAK9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

213810:RUM RS03440
gene id: 213810:RUM_RS03440
uniprot id: D4LBB8
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

213810:RUM RS06235
gene id: 213810:RUM_RS06235
uniprot id: D4LCS1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

213810:RUM RS00195
gene id: 213810:RUM_RS00195
uniprot id: D4L9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS01305
gene id: 213810:RUM_RS01305
uniprot id: D4LA72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

213810:RUM RS07130
gene id: 213810:RUM_RS07130
uniprot id: D4LD74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

213810:RUM RS00510
gene id: 213810:RUM_RS00510
uniprot id: D4L9S8
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

213810:RUM RS10735
gene id: 213810:RUM_RS10735
uniprot id: D4LF27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

213810:RUM RS07760
gene id: 213810:RUM_RS07760
uniprot id: D4LDI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

213810:RUM RS06850
gene id: 213810:RUM_RS06850
uniprot id: D4LD25
names: Similarity
messages: Belongs to the thioredoxin family.

213810:RUM RS11360
gene id: 213810:RUM_RS11360
uniprot id: D4LFD3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

213810:RUM RS07290
gene id: 213810:RUM_RS07290
uniprot id: D4LDA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

213810:RUM RS03995
gene id: 213810:RUM_RS03995
uniprot id: D4LBL6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

213810:RUM RS08885
gene id: 213810:RUM_RS08885
uniprot id: D4LE40
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

213810:RUM RS05225
gene id: 213810:RUM_RS05225
uniprot id: D4LC98
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

213810:RUM RS01560
gene id: 213810:RUM_RS01560
uniprot id: D4LAB7
names: Similarity
messages: Belongs to the glycosyl hydrolase.

213810:RUM RS09480
gene id: 213810:RUM_RS09480
uniprot id: D4LEE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS06345
gene id: 213810:RUM_RS06345
uniprot id: D4LCT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

213810:RUM RS06920
gene id: 213810:RUM_RS06920
uniprot id: D4LD38
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

213810:RUM RS01195
gene id: 213810:RUM_RS01195
uniprot id: D4LA51
names: Similarity
messages: Belongs to the UPF0297 family.

213810:RUM RS01800
gene id: 213810:RUM_RS01800
uniprot id: D4LAG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

213810:RUM RS10540
gene id: 213810:RUM_RS10540
uniprot id: D4LEZ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

213810:RUM RS02425
gene id: 213810:RUM_RS02425
uniprot id: D4LAT3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS06410
gene id: 213810:RUM_RS06410
uniprot id: D4LCV1
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

213810:RUM RS04660
gene id: 213810:RUM_RS04660
uniprot id: D4LBZ5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

213810:RUM RS04550
gene id: 213810:RUM_RS04550
uniprot id: D4LBX4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

213810:RUM RS07285
gene id: 213810:RUM_RS07285
uniprot id: D4LDA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

213810:RUM RS09960
gene id: 213810:RUM_RS09960
uniprot id: D4LEN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

213810:RUM RS05955
gene id: 213810:RUM_RS05955
uniprot id: D4LCM5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

213810:RUM RS07250
gene id: 213810:RUM_RS07250
uniprot id: D4LD94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

213810:RUM RS00560
gene id: 213810:RUM_RS00560
uniprot id: D4L9T8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

213810:RUM RS11685
gene id: 213810:RUM_RS11685
uniprot id: D4LFJ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

213810:RUM RS07515
gene id: 213810:RUM_RS07515
uniprot id: D4LDE1
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS03625
gene id: 213810:RUM_RS03625
uniprot id: D4LBF3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

213810:RUM RS02775
gene id: 213810:RUM_RS02775
uniprot id: D4LAZ9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11575
gene id: 213810:RUM_RS11575
uniprot id: D4LFH5
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS09930
gene id: 213810:RUM_RS09930
uniprot id: D4LEM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

213810:RUM RS06315
gene id: 213810:RUM_RS06315
uniprot id: D4LCT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

213810:RUM RS03500
gene id: 213810:RUM_RS03500
uniprot id: D4LBD0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

213810:RUM RS01275
gene id: 213810:RUM_RS01275
uniprot id: D4LA67
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

213810:RUM RS00580
gene id: 213810:RUM_RS00580
uniprot id: D4L9U2
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

213810:RUM RS01805
gene id: 213810:RUM_RS01805
uniprot id: D4LAG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

213810:RUM RS01520
gene id: 213810:RUM_RS01520
uniprot id: D4LAA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07815
gene id: 213810:RUM_RS07815
uniprot id: D4LDJ7
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

213810:RUM RS07830
gene id: 213810:RUM_RS07830
uniprot id: D4LDK0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

213810:RUM RS00155
gene id: 213810:RUM_RS00155
uniprot id: D4L9M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

213810:RUM RS07070
gene id: 213810:RUM_RS07070
uniprot id: D4LD65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

213810:RUM RS12060
gene id: 213810:RUM_RS12060
uniprot id: D4LCP6
names: Similarity
messages: Belongs to the plasmid mobilization pre family.

213810:RUM RS03520
gene id: 213810:RUM_RS03520
uniprot id: D4LBD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

213810:RUM RS07035
gene id: 213810:RUM_RS07035
uniprot id: D4LD59
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

213810:RUM RS06120
gene id: 213810:RUM_RS06120
uniprot id: D4LCQ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

213810:RUM RS01730
gene id: 213810:RUM_RS01730
uniprot id: D4LAF3
names: Similarity
messages: Belongs to the GSP E family.

213810:RUM RS00440
gene id: 213810:RUM_RS00440
uniprot id: D4L9R6
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

213810:RUM RS10805
gene id: 213810:RUM_RS10805
uniprot id: D4LF36
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

213810:RUM RS02320
gene id: 213810:RUM_RS02320
uniprot id: D4LAR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07155
gene id: 213810:RUM_RS07155
uniprot id: D4LD79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

213810:RUM RS09965
gene id: 213810:RUM_RS09965
uniprot id: D4LEN5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

213810:RUM RS10840
gene id: 213810:RUM_RS10840
uniprot id: D4LF43
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

213810:RUM RS08905
gene id: 213810:RUM_RS08905
uniprot id: D4LE44
names: Similarity
messages: Belongs to the peptidase S11 family.

213810:RUM RS02665
gene id: 213810:RUM_RS02665
uniprot id: D4LAX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS09105
gene id: 213810:RUM_RS09105
uniprot id: D4LE76
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS12120
gene id: 213810:RUM_RS12120
uniprot id: D4LDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

213810:RUM RS00150
gene id: 213810:RUM_RS00150
uniprot id: D4L9M0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

213810:RUM RS11605
gene id: 213810:RUM_RS11605
uniprot id: D4LFH9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

213810:RUM RS07910
gene id: 213810:RUM_RS07910
uniprot id: D4LDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

213810:RUM RS11610
gene id: 213810:RUM_RS11610
uniprot id: D4LFI0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

213810:RUM RS07740
gene id: 213810:RUM_RS07740
uniprot id: D4LDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

213810:RUM RS04745
gene id: 213810:RUM_RS04745
uniprot id: D4LC09
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

213810:RUM RS03510
gene id: 213810:RUM_RS03510
uniprot id: D4LBD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

213810:RUM RS06900
gene id: 213810:RUM_RS06900
uniprot id: D4LD34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

213810:RUM RS01540
gene id: 213810:RUM_RS01540
uniprot id: D4LAB3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

213810:RUM RS00395
gene id: 213810:RUM_RS00395
uniprot id: D4L9R0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

213810:RUM RS05810
gene id: 213810:RUM_RS05810
uniprot id: D4LCJ9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07710
gene id: 213810:RUM_RS07710
uniprot id: D4LDH8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

213810:RUM RS08170
gene id: 213810:RUM_RS08170
uniprot id: D4LDR2
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

213810:RUM RS09440
gene id: 213810:RUM_RS09440
uniprot id: D4LED8
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS05320
gene id: 213810:RUM_RS05320
uniprot id: D4LCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

213810:RUM RS04320
gene id: 213810:RUM_RS04320
uniprot id: D4LBS6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

213810:RUM RS06425
gene id: 213810:RUM_RS06425
uniprot id: D4LCV4
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

213810:RUM RS04710
gene id: 213810:RUM_RS04710
uniprot id: D4LC03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

213810:RUM RS10340
gene id: 213810:RUM_RS10340
uniprot id: D4LEV4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

213810:RUM RS08295
gene id: 213810:RUM_RS08295
uniprot id: D4LDT4
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS09570
gene id: 213810:RUM_RS09570
uniprot id: D4LEG2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

213810:RUM RS01170
gene id: 213810:RUM_RS01170
uniprot id: D4LA45
names: Similarity
messages: Belongs to the glutamate synthase family.

213810:RUM RS06040
gene id: 213810:RUM_RS06040
uniprot id: D4LCP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

213810:RUM RS10615
gene id: 213810:RUM_RS10615
uniprot id: D4LF06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

213810:RUM RS02145
gene id: 213810:RUM_RS02145
uniprot id: D4LAM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

213810:RUM RS00350
gene id: 213810:RUM_RS00350
uniprot id: D4L9Q2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

213810:RUM RS05410
gene id: 213810:RUM_RS05410
uniprot id: D4LCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

213810:RUM RS09095
gene id: 213810:RUM_RS09095
uniprot id: D4LE74
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07275
gene id: 213810:RUM_RS07275
uniprot id: D4LD98
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

213810:RUM RS06845
gene id: 213810:RUM_RS06845
uniprot id: D4LD24
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

213810:RUM RS10325
gene id: 213810:RUM_RS10325
uniprot id: D4LEV1
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

213810:RUM RS05855
gene id: 213810:RUM_RS05855
uniprot id: D4LCK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

213810:RUM RS02630
gene id: 213810:RUM_RS02630
uniprot id: D4LAX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS12220
gene id: 213810:RUM_RS12220
uniprot id: D4LER4
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

213810:RUM RS04415
gene id: 213810:RUM_RS04415
uniprot id: D4LBU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

213810:RUM RS02865
gene id: 213810:RUM_RS02865
uniprot id: D4LB17
names: Similarity
messages: Belongs to the band 7/mec-2 family.

213810:RUM RS04290
gene id: 213810:RUM_RS04290
uniprot id: D4LBS0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

213810:RUM RS05635
gene id: 213810:RUM_RS05635
uniprot id: D4LCH3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07375
gene id: 213810:RUM_RS07375
uniprot id: D4LDB4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

213810:RUM RS07150
gene id: 213810:RUM_RS07150
uniprot id: D4LD78
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

213810:RUM RS04595
gene id: 213810:RUM_RS04595
uniprot id: D4LBY3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS01665
gene id: 213810:RUM_RS01665
uniprot id: D4LAD9
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

213810:RUM RS01185
gene id: 213810:RUM_RS01185
uniprot id: D4LA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P(II) protein family.
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

213810:RUM RS09250
gene id: 213810:RUM_RS09250
uniprot id: D4LEA4
names: Similarity
messages: Belongs to the TlyA family.

213810:RUM RS01640
gene id: 213810:RUM_RS01640
uniprot id: D4LAD4
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

213810:RUM RS09035
gene id: 213810:RUM_RS09035
uniprot id: D4LE63
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

213810:RUM RS04255
gene id: 213810:RUM_RS04255
uniprot id: D4LBR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS10105
gene id: 213810:RUM_RS10105
uniprot id: D4LEQ9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

213810:RUM RS12090
gene id: 213810:RUM_RS12090
uniprot id: D4LD19
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

213810:RUM RS07195
gene id: 213810:RUM_RS07195
uniprot id: D4LD84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

213810:RUM RS10025
gene id: 213810:RUM_RS10025
uniprot id: D4LEP4
names: Similarity
messages: Belongs to the SurE nucleotidase family.

213810:RUM RS06960
gene id: 213810:RUM_RS06960
uniprot id: D4LD45
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

213810:RUM RS01215
gene id: 213810:RUM_RS01215
uniprot id: D4LA55
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS03075
gene id: 213810:RUM_RS03075
uniprot id: D4LB57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

213810:RUM RS00215
gene id: 213810:RUM_RS00215
uniprot id: D4L9N2
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

213810:RUM RS00925
gene id: 213810:RUM_RS00925
uniprot id: D4LA03
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

213810:RUM RS00250
gene id: 213810:RUM_RS00250
uniprot id: D4L9N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

213810:RUM RS11620
gene id: 213810:RUM_RS11620
uniprot id: D4LFI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

213810:RUM RS02940
gene id: 213810:RUM_RS02940
uniprot id: D4LB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

213810:RUM RS09575
gene id: 213810:RUM_RS09575
uniprot id: D4LEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

213810:RUM RS00555
gene id: 213810:RUM_RS00555
uniprot id: D4L9T7
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

213810:RUM RS02395
gene id: 213810:RUM_RS02395
uniprot id: D4LAS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

213810:RUM RS11110
gene id: 213810:RUM_RS11110
uniprot id: D4LF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS06325
gene id: 213810:RUM_RS06325
uniprot id: D4LCT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS08100
gene id: 213810:RUM_RS08100
uniprot id: D4LDP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

213810:RUM RS02265
gene id: 213810:RUM_RS02265
uniprot id: D4LAQ3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

213810:RUM RS04315
gene id: 213810:RUM_RS04315
uniprot id: D4LBS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

213810:RUM RS00540
gene id: 213810:RUM_RS00540
uniprot id: D4L9T4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

213810:RUM RS01045
gene id: 213810:RUM_RS01045
uniprot id: D4LA26
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS02005
gene id: 213810:RUM_RS02005
uniprot id: D4LAK3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

213810:RUM RS11105
gene id: 213810:RUM_RS11105
uniprot id: D4LF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS07225
gene id: 213810:RUM_RS07225
uniprot id: D4LD90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

213810:RUM RS11435
gene id: 213810:RUM_RS11435
uniprot id: D4LFE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

213810:RUM RS10390
gene id: 213810:RUM_RS10390
uniprot id: D4LEW3
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

213810:RUM RS08040
gene id: 213810:RUM_RS08040
uniprot id: D4LDN9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

213810:RUM RS11600
gene id: 213810:RUM_RS11600
uniprot id: D4LFH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS10220
gene id: 213810:RUM_RS10220
uniprot id: D4LET1
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

213810:RUM RS05670
gene id: 213810:RUM_RS05670
uniprot id: D4LCH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

213810:RUM RS01970
gene id: 213810:RUM_RS01970
uniprot id: D4LAJ6
names: Subcellular Location Annotation
messages: Cell membrane

213810:RUM RS11020
gene id: 213810:RUM_RS11020
uniprot id: D4LF72
names: Similarity
messages: Belongs to the DtxR/MntR family.

213810:RUM RS04130
gene id: 213810:RUM_RS04130
uniprot id: D4LBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

213810:RUM RS09380
gene id: 213810:RUM_RS09380
uniprot id: D4LEC7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS09900
gene id: 213810:RUM_RS09900
uniprot id: D4LEM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

213810:RUM RS00235
gene id: 213810:RUM_RS00235
uniprot id: D4L9N6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

213810:RUM RS09895
gene id: 213810:RUM_RS09895
uniprot id: D4LEM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

213810:RUM RS10830
gene id: 213810:RUM_RS10830
uniprot id: D4LF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

213810:RUM RS10225
gene id: 213810:RUM_RS10225
uniprot id: D4LET2
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

213810:RUM RS04065
gene id: 213810:RUM_RS04065
uniprot id: D4LBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

213810:RUM RS09395
gene id: 213810:RUM_RS09395
uniprot id: D4LEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

213810:RUM RS10080
gene id: 213810:RUM_RS10080
uniprot id: D4LEQ6
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS01405
gene id: 213810:RUM_RS01405
uniprot id: D4LA91
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

213810:RUM RS05605
gene id: 213810:RUM_RS05605
uniprot id: D4LCG6
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11615
gene id: 213810:RUM_RS11615
uniprot id: D4LFI1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

213810:RUM RS00225
gene id: 213810:RUM_RS00225
uniprot id: D4L9N4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

213810:RUM RS09540
gene id: 213810:RUM_RS09540
uniprot id: D4LEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

213810:RUM RS08585
gene id: 213810:RUM_RS08585
uniprot id: D4LDY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

213810:RUM RS03195
gene id: 213810:RUM_RS03195
uniprot id: D4LB79
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

213810:RUM RS07545
gene id: 213810:RUM_RS07545
uniprot id: D4LDE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS09260
gene id: 213810:RUM_RS09260
uniprot id: D4LEA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

213810:RUM RS11150
gene id: 213810:RUM_RS11150
uniprot id: D4LF93
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

213810:RUM RS04885
gene id: 213810:RUM_RS04885
uniprot id: D4LC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpsD/CapB family.
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

213810:RUM RS04355
gene id: 213810:RUM_RS04355
uniprot id: D4LBT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

213810:RUM RS09235
gene id: 213810:RUM_RS09235
uniprot id: D4LEA2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

213810:RUM RS08195
gene id: 213810:RUM_RS08195
uniprot id: D4LDR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

213810:RUM RS07540
gene id: 213810:RUM_RS07540
uniprot id: D4LDE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

213810:RUM RS07135
gene id: 213810:RUM_RS07135
uniprot id: D4LD75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

213810:RUM RS01955
gene id: 213810:RUM_RS01955
uniprot id: D4LAJ3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10800
gene id: 213810:RUM_RS10800
uniprot id: D4LF35
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

213810:RUM RS11305
gene id: 213810:RUM_RS11305
uniprot id: D4LFC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

213810:RUM RS07470
gene id: 213810:RUM_RS07470
uniprot id: D4LDD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

213810:RUM RS01550
gene id: 213810:RUM_RS01550
uniprot id: D4LAB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

213810:RUM RS09715
gene id: 213810:RUM_RS09715
uniprot id: D4LEI9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

213810:RUM RS02300
gene id: 213810:RUM_RS02300
uniprot id: D4LAR1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

213810:RUM RS03365
gene id: 213810:RUM_RS03365
uniprot id: D4LBA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

213810:RUM RS01880
gene id: 213810:RUM_RS01880
uniprot id: D4LAH8
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS05685
gene id: 213810:RUM_RS05685
uniprot id: D4LCI0
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10205
gene id: 213810:RUM_RS10205
uniprot id: D4LES8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

213810:RUM RS04275
gene id: 213810:RUM_RS04275
uniprot id: D4LBR7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

213810:RUM RS01235
gene id: 213810:RUM_RS01235
uniprot id: D4LA60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

213810:RUM RS11230
gene id: 213810:RUM_RS11230
uniprot id: D4LFA8
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

213810:RUM RS02720
gene id: 213810:RUM_RS02720
uniprot id: D4LAY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

213810:RUM RS09135
gene id: 213810:RUM_RS09135
uniprot id: D4LE82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS04365
gene id: 213810:RUM_RS04365
uniprot id: D4LBT5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS04855
gene id: 213810:RUM_RS04855
uniprot id: D4LC30
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

213810:RUM RS03170
gene id: 213810:RUM_RS03170
uniprot id: D4LB75
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

213810:RUM RS09580
gene id: 213810:RUM_RS09580
uniprot id: D4LEG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

213810:RUM RS09920
gene id: 213810:RUM_RS09920
uniprot id: D4LEM6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS06280
gene id: 213810:RUM_RS06280
uniprot id: D4LCS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

213810:RUM RS09145
gene id: 213810:RUM_RS09145
uniprot id: D4LE84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

213810:RUM RS03535
gene id: 213810:RUM_RS03535
uniprot id: D4LBD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

213810:RUM RS11200
gene id: 213810:RUM_RS11200
uniprot id: D4LFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

213810:RUM RS01785
gene id: 213810:RUM_RS01785
uniprot id: D4LAG3
names: Function
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

213810:RUM RS04115
gene id: 213810:RUM_RS04115
uniprot id: D4LBN6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

213810:RUM RS10975
gene id: 213810:RUM_RS10975
uniprot id: D4LF62
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

213810:RUM RS08070
gene id: 213810:RUM_RS08070
uniprot id: D4LDP3
names: Similarity
messages: Belongs to the glutamine synthetase family.

213810:RUM RS08085
gene id: 213810:RUM_RS08085
uniprot id: D4LDP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

213810:RUM RS02095
gene id: 213810:RUM_RS02095
uniprot id: D4LAM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

213810:RUM RS00360
gene id: 213810:RUM_RS00360
uniprot id: D4L9Q4
names: Similarity
messages: Belongs to the thioesterase family.

213810:RUM RS10285
gene id: 213810:RUM_RS10285
uniprot id: D4LEU3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

213810:RUM RS01650
gene id: 213810:RUM_RS01650
uniprot id: D4LAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

213810:RUM RS03465
gene id: 213810:RUM_RS03465
uniprot id: D4LBC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

213810:RUM RS01670
gene id: 213810:RUM_RS01670
uniprot id: D4LAE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

213810:RUM RS11400
gene id: 213810:RUM_RS11400
uniprot id: D4LFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

213810:RUM RS12045
gene id: 213810:RUM_RS12045
uniprot id: D4LCH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

213810:RUM RS09090
gene id: 213810:RUM_RS09090
uniprot id: D4LE73
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

213810:RUM RS05850
gene id: 213810:RUM_RS05850
uniprot id: D4LCK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

213810:RUM RS11210
gene id: 213810:RUM_RS11210
uniprot id: D4LFA4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS11425
gene id: 213810:RUM_RS11425
uniprot id: D4LFE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

213810:RUM RS06515
gene id: 213810:RUM_RS06515
uniprot id: D4LCW9
names: Similarity
messages: Belongs to the sigma-70 factor family.

213810:RUM RS10010
gene id: 213810:RUM_RS10010
uniprot id: D4LEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS05745
gene id: 213810:RUM_RS05745
uniprot id: D4LCI9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

213810:RUM RS09315
gene id: 213810:RUM_RS09315
uniprot id: D4LEB6
names: Subcellular Location Annotation
messages: Cell membrane

213810:RUM RS07745
gene id: 213810:RUM_RS07745
uniprot id: D4LDI5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

213810:RUM RS11030
gene id: 213810:RUM_RS11030
uniprot id: D4LF74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS13185
gene id: 213810:RUM_RS13185
uniprot id: D4LF64
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

213810:RUM RS11405
gene id: 213810:RUM_RS11405
uniprot id: D4LFE2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

213810:RUM RS06440
gene id: 213810:RUM_RS06440
uniprot id: D4LCV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

213810:RUM RS11815
gene id: 213810:RUM_RS11815
uniprot id: D4L9Q0
names: Similarity
messages: Belongs to the thioesterase family.

213810:RUM RS01350
gene id: 213810:RUM_RS01350
uniprot id: D4LA81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS10440
gene id: 213810:RUM_RS10440
uniprot id: D4LEX3
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS01645
gene id: 213810:RUM_RS01645
uniprot id: D4LAD5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

213810:RUM RS10640
gene id: 213810:RUM_RS10640
uniprot id: D4LF11
names: Similarity
messages: Belongs to the pyruvate kinase family.

213810:RUM RS09115
gene id: 213810:RUM_RS09115
uniprot id: D4LE77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

213810:RUM RS08555
gene id: 213810:RUM_RS08555
uniprot id: D4LDY0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

213810:RUM RS06915
gene id: 213810:RUM_RS06915
uniprot id: D4LD36
names: Similarity
messages: Belongs to the ArsC family.

213810:RUM RS08235
gene id: 213810:RUM_RS08235
uniprot id: D4LDS3
names: Similarity
messages: Belongs to the peptidase S24 family.

213810:RUM RS00210
gene id: 213810:RUM_RS00210
uniprot id: D4L9N1
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

213810:RUM RS10825
gene id: 213810:RUM_RS10825
uniprot id: D4LF40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

213810:RUM RS06050
gene id: 213810:RUM_RS06050
uniprot id: D4LCP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

213810:RUM RS07505
gene id: 213810:RUM_RS07505
uniprot id: D4LDD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

213810:RUM RS11480
gene id: 213810:RUM_RS11480
uniprot id: D4LFF6
names: Similarity
messages: Belongs to the fabD family.

213810:RUM RS07160
gene id: 213810:RUM_RS07160
uniprot id: D4LD80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

213810:RUM RS00075
gene id: 213810:RUM_RS00075
uniprot id: D4L9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

213810:RUM RS03540
gene id: 213810:RUM_RS03540
uniprot id: D4LBD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

213810:RUM RS00380
gene id: 213810:RUM_RS00380
uniprot id: D4L9Q7
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10410
gene id: 213810:RUM_RS10410
uniprot id: D4LEW6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

213810:RUM RS10450
gene id: 213810:RUM_RS10450
uniprot id: D4LEX5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07255
gene id: 213810:RUM_RS07255
uniprot id: D4LD95
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

213810:RUM RS00620
gene id: 213810:RUM_RS00620
uniprot id: D4L9V0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

213810:RUM RS04050
gene id: 213810:RUM_RS04050
uniprot id: D4LBM4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

213810:RUM RS00920
gene id: 213810:RUM_RS00920
uniprot id: D4LA02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS08110
gene id: 213810:RUM_RS08110
uniprot id: D4LDQ1
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

213810:RUM RS07235
gene id: 213810:RUM_RS07235
uniprot id: D4LD92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS00270
gene id: 213810:RUM_RS00270
uniprot id: D4L9P3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

213810:RUM RS03090
gene id: 213810:RUM_RS03090
uniprot id: D4LB60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

213810:RUM RS00795
gene id: 213810:RUM_RS00795
uniprot id: D4L9X6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

213810:RUM RS04380
gene id: 213810:RUM_RS04380
uniprot id: D4LBT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

213810:RUM RS06375
gene id: 213810:RUM_RS06375
uniprot id: D4LCU5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS03190
gene id: 213810:RUM_RS03190
uniprot id: D4LB78
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

213810:RUM RS11255
gene id: 213810:RUM_RS11255
uniprot id: D4LFB2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS10565
gene id: 213810:RUM_RS10565
uniprot id: D4LEZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

213810:RUM RS12225
gene id: 213810:RUM_RS12225
uniprot id: D4LET5
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

213810:RUM RS09605
gene id: 213810:RUM_RS09605
uniprot id: D4LEG9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

213810:RUM RS09550
gene id: 213810:RUM_RS09550
uniprot id: D4LEF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

213810:RUM RS00200
gene id: 213810:RUM_RS00200
uniprot id: D4L9M9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07045
gene id: 213810:RUM_RS07045
uniprot id: D4LD61
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

213810:RUM RS05975
gene id: 213810:RUM_RS05975
uniprot id: D4LCM9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10560
gene id: 213810:RUM_RS10560
uniprot id: D4LEZ6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS01890
gene id: 213810:RUM_RS01890
uniprot id: D4LAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

213810:RUM RS10880
gene id: 213810:RUM_RS10880
uniprot id: D4LF50
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

213810:RUM RS02950
gene id: 213810:RUM_RS02950
uniprot id: D4LB34
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

213810:RUM RS00570
gene id: 213810:RUM_RS00570
uniprot id: D4L9U0
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

213810:RUM RS06110
gene id: 213810:RUM_RS06110
uniprot id: D4LCQ2
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11315
gene id: 213810:RUM_RS11315
uniprot id: D4LFC4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

213810:RUM RS06290
gene id: 213810:RUM_RS06290
uniprot id: D4LCT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

213810:RUM RS11355
gene id: 213810:RUM_RS11355
uniprot id: D4LFD2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

213810:RUM RS03105
gene id: 213810:RUM_RS03105
uniprot id: D4LB62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

213810:RUM RS07390
gene id: 213810:RUM_RS07390
uniprot id: D4LDB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

213810:RUM RS10845
gene id: 213810:RUM_RS10845
uniprot id: D4LF44
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

213810:RUM RS02400
gene id: 213810:RUM_RS02400
uniprot id: D4LAS9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS00220
gene id: 213810:RUM_RS00220
uniprot id: D4L9N3
names: Similarity
messages: Belongs to the CdaR family.

213810:RUM RS07755
gene id: 213810:RUM_RS07755
uniprot id: D4LDI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: Belongs to the glycosyl hydrolase 43 family.

213810:RUM RS09410
gene id: 213810:RUM_RS09410
uniprot id: D4LED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

213810:RUM RS00275
gene id: 213810:RUM_RS00275
uniprot id: D4L9P4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

213810:RUM RS02325
gene id: 213810:RUM_RS02325
uniprot id: D4LAR6
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

213810:RUM RS07440
gene id: 213810:RUM_RS07440
uniprot id: D4LDC7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

213810:RUM RS02115
gene id: 213810:RUM_RS02115
uniprot id: D4LAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

213810:RUM RS10545
gene id: 213810:RUM_RS10545
uniprot id: D4LEZ3
names: Similarity
messages: Belongs to the UPF0751 family.

213810:RUM RS11120
gene id: 213810:RUM_RS11120
uniprot id: D4LF91
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10730
gene id: 213810:RUM_RS10730
uniprot id: D4LF26
names: Similarity
messages: Belongs to the UDPGP type 1 family.

213810:RUM RS01210
gene id: 213810:RUM_RS01210
uniprot id: D4LA54
names: Similarity
messages: Belongs to the asp23 family.

213810:RUM RS01340
gene id: 213810:RUM_RS01340
uniprot id: D4LA79
names: Similarity
messages: Belongs to the PspA/IM30 family.

213810:RUM RS10005
gene id: 213810:RUM_RS10005
uniprot id: D4LEP0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

213810:RUM RS10305
gene id: 213810:RUM_RS10305
uniprot id: D4LEU7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

213810:RUM RS07190
gene id: 213810:RUM_RS07190
uniprot id: D4LD83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

213810:RUM RS05175
gene id: 213810:RUM_RS05175
uniprot id: D4LC87
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS09615
gene id: 213810:RUM_RS09615
uniprot id: D4LEH0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

213810:RUM RS02385
gene id: 213810:RUM_RS02385
uniprot id: D4LAS6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

213810:RUM RS05010
gene id: 213810:RUM_RS05010
uniprot id: D4LC57
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11085
gene id: 213810:RUM_RS11085
uniprot id: D4LF84
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

213810:RUM RS00465
gene id: 213810:RUM_RS00465
uniprot id: D4L9S1
names: Similarity
messages: Belongs to the manganese catalase family.

213810:RUM RS04125
gene id: 213810:RUM_RS04125
uniprot id: D4LBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS04160
gene id: 213810:RUM_RS04160
uniprot id: D4LBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

213810:RUM RS06885
gene id: 213810:RUM_RS06885
uniprot id: D4LD31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

213810:RUM RS09295
gene id: 213810:RUM_RS09295
uniprot id: D4LEB3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

213810:RUM RS00480
gene id: 213810:RUM_RS00480
uniprot id: D4L9S4
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

213810:RUM RS07845
gene id: 213810:RUM_RS07845
uniprot id: D4LDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

213810:RUM RS12235
gene id: 213810:RUM_RS12235
uniprot id: D4LEY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

213810:RUM RS06000
gene id: 213810:RUM_RS06000
uniprot id: D4LCN4
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

213810:RUM RS11430
gene id: 213810:RUM_RS11430
uniprot id: D4LFE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

213810:RUM RS10405
gene id: 213810:RUM_RS10405
uniprot id: D4LEW5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

213810:RUM RS04620
gene id: 213810:RUM_RS04620
uniprot id: D4LBY7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

213810:RUM RS09085
gene id: 213810:RUM_RS09085
uniprot id: D4LE72
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

213810:RUM RS11415
gene id: 213810:RUM_RS11415
uniprot id: D4LFE4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

213810:RUM RS11590
gene id: 213810:RUM_RS11590
uniprot id: D4LFH7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS01815
gene id: 213810:RUM_RS01815
uniprot id: D4LAG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

213810:RUM RS05245
gene id: 213810:RUM_RS05245
uniprot id: D4LCA2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS02040
gene id: 213810:RUM_RS02040
uniprot id: D4LAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

213810:RUM RS08210
gene id: 213810:RUM_RS08210
uniprot id: D4LDR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

213810:RUM RS06600
gene id: 213810:RUM_RS06600
uniprot id: D4LCY5
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

213810:RUM RS04000
gene id: 213810:RUM_RS04000
uniprot id: D4LBL7
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

213810:RUM RS01575
gene id: 213810:RUM_RS01575
uniprot id: D4LAC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

213810:RUM RS01935
gene id: 213810:RUM_RS01935
uniprot id: D4LAI9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

213810:RUM RS04270
gene id: 213810:RUM_RS04270
uniprot id: D4LBR6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

213810:RUM RS02410
gene id: 213810:RUM_RS02410
uniprot id: D4LAT1
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07260
gene id: 213810:RUM_RS07260
uniprot id: D4LD96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

213810:RUM RS07765
gene id: 213810:RUM_RS07765
uniprot id: D4LDI9
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

213810:RUM RS11165
gene id: 213810:RUM_RS11165
uniprot id: D4LF96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS02295
gene id: 213810:RUM_RS02295
uniprot id: D4LAR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

213810:RUM RS08845
gene id: 213810:RUM_RS08845
uniprot id: D4LE32
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

213810:RUM RS09505
gene id: 213810:RUM_RS09505
uniprot id: D4LEF0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS07525
gene id: 213810:RUM_RS07525
uniprot id: D4LDE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

213810:RUM RS07380
gene id: 213810:RUM_RS07380
uniprot id: D4LDB5
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

213810:RUM RS11310
gene id: 213810:RUM_RS11310
uniprot id: D4LFC3
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

213810:RUM RS03010
gene id: 213810:RUM_RS03010
uniprot id: D4LB45
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

213810:RUM RS11350
gene id: 213810:RUM_RS11350
uniprot id: D4LFD1
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS04170
gene id: 213810:RUM_RS04170
uniprot id: D4LBP6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

213810:RUM RS05490
gene id: 213810:RUM_RS05490
uniprot id: D4LCE7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

213810:RUM RS03530
gene id: 213810:RUM_RS03530
uniprot id: D4LBD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

213810:RUM RS02970
gene id: 213810:RUM_RS02970
uniprot id: D4LB38
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

213810:RUM RS10585
gene id: 213810:RUM_RS10585
uniprot id: D4LF00
names: Similarity
messages: Belongs to the 'phage' integrase family.

213810:RUM RS06985
gene id: 213810:RUM_RS06985
uniprot id: D4LD50
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS03080
gene id: 213810:RUM_RS03080
uniprot id: D4LB58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

213810:RUM RS09225
gene id: 213810:RUM_RS09225
uniprot id: D4LEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

213810:RUM RS04185
gene id: 213810:RUM_RS04185
uniprot id: D4LBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

213810:RUM RS03595
gene id: 213810:RUM_RS03595
uniprot id: D4LBE7
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

213810:RUM RS03735
gene id: 213810:RUM_RS03735
uniprot id: D4LBH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

213810:RUM RS02490
gene id: 213810:RUM_RS02490
uniprot id: D4LAU4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS07140
gene id: 213810:RUM_RS07140
uniprot id: D4LD76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

213810:RUM RS00530
gene id: 213810:RUM_RS00530
uniprot id: D4L9T2
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

213810:RUM RS02305
gene id: 213810:RUM_RS02305
uniprot id: D4LAR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

213810:RUM RS07085
gene id: 213810:RUM_RS07085
uniprot id: D4LD68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

213810:RUM RS03980
gene id: 213810:RUM_RS03980
uniprot id: D4LBL3
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

213810:RUM RS02390
gene id: 213810:RUM_RS02390
uniprot id: D4LAS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

213810:RUM RS08115
gene id: 213810:RUM_RS08115
uniprot id: D4LDQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

213810:RUM RS01875
gene id: 213810:RUM_RS01875
uniprot id: D4LAH7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS09275
gene id: 213810:RUM_RS09275
uniprot id: D4LEA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

213810:RUM RS02930
gene id: 213810:RUM_RS02930
uniprot id: D4LB30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

213810:RUM RS03870
gene id: 213810:RUM_RS03870
uniprot id: D4LBJ3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

213810:RUM RS08860
gene id: 213810:RUM_RS08860
uniprot id: D4LE35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

213810:RUM RS06340
gene id: 213810:RUM_RS06340
uniprot id: D4LCT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

213810:RUM RS01180
gene id: 213810:RUM_RS01180
uniprot id: D4LA47
names: Similarity
messages: Belongs to the glutamine synthetase family.

213810:RUM RS08200
gene id: 213810:RUM_RS08200
uniprot id: D4LDR7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

213810:RUM RS07715
gene id: 213810:RUM_RS07715
uniprot id: D4LDH9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

213810:RUM RS06970
gene id: 213810:RUM_RS06970
uniprot id: D4LD47
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS02245
gene id: 213810:RUM_RS02245
uniprot id: D4LAP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS01790
gene id: 213810:RUM_RS01790
uniprot id: D4LAG4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

213810:RUM RS04180
gene id: 213810:RUM_RS04180
uniprot id: D4LBP9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

213810:RUM RS09940
gene id: 213810:RUM_RS09940
uniprot id: D4LEN0
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

213810:RUM RS04370
gene id: 213810:RUM_RS04370
uniprot id: D4LBT6
names: Similarity
messages: Belongs to the TrpC family.

213810:RUM RS08590
gene id: 213810:RUM_RS08590
uniprot id: D4LDY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

213810:RUM RS07395
gene id: 213810:RUM_RS07395
uniprot id: D4LDB8
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

213810:RUM RS03025
gene id: 213810:RUM_RS03025
uniprot id: D4LB49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

213810:RUM RS04720
gene id: 213810:RUM_RS04720
uniprot id: D4LC05
names: Similarity
messages: Belongs to the peptidase S41A family.

213810:RUM RS01695
gene id: 213810:RUM_RS01695
uniprot id: D4LAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

213810:RUM RS10745
gene id: 213810:RUM_RS10745
uniprot id: D4LF29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

213810:RUM RS04210
gene id: 213810:RUM_RS04210
uniprot id: D4LBQ5
names: Similarity
messages: Belongs to the UPF0473 family.

213810:RUM RS11520
gene id: 213810:RUM_RS11520
uniprot id: D4LFG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

213810:RUM RS10045
gene id: 213810:RUM_RS10045
uniprot id: D4LEP9
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

213810:RUM RS05780
gene id: 213810:RUM_RS05780
uniprot id: D4LCJ3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

213810:RUM RS01690
gene id: 213810:RUM_RS01690
uniprot id: D4LAE5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

213810:RUM RS06240
gene id: 213810:RUM_RS06240
uniprot id: D4LCS2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

213810:RUM RS11070
gene id: 213810:RUM_RS11070
uniprot id: D4LF81
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

213810:RUM RS08120
gene id: 213810:RUM_RS08120
uniprot id: D4LDQ3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS03385
gene id: 213810:RUM_RS03385
uniprot id: D4LBB1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

213810:RUM RS08090
gene id: 213810:RUM_RS08090
uniprot id: D4LDP7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

213810:RUM RS09065
gene id: 213810:RUM_RS09065
uniprot id: D4LE68
names: Similarity
messages: Belongs to the GARS family.

213810:RUM RS05240
gene id: 213810:RUM_RS05240
uniprot id: D4LCA1
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

213810:RUM RS04035
gene id: 213810:RUM_RS04035
uniprot id: D4LBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

213810:RUM RS07435
gene id: 213810:RUM_RS07435
uniprot id: D4LDC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

213810:RUM RS07480
gene id: 213810:RUM_RS07480
uniprot id: D4LDD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

213810:RUM RS08565
gene id: 213810:RUM_RS08565
uniprot id: D4LDY1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

213810:RUM RS08155
gene id: 213810:RUM_RS08155
uniprot id: D4LDQ9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS11390
gene id: 213810:RUM_RS11390
uniprot id: D4LFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

213810:RUM RS07580
gene id: 213810:RUM_RS07580
uniprot id: D4LDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

213810:RUM RS05250
gene id: 213810:RUM_RS05250
uniprot id: D4LCA3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

213810:RUM RS02985
gene id: 213810:RUM_RS02985
uniprot id: D4LB40
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

213810:RUM RS09500
gene id: 213810:RUM_RS09500
uniprot id: D4LEE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

213810:RUM RS00085
gene id: 213810:RUM_RS00085
uniprot id: D4L9K8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

213810:RUM RS06460
gene id: 213810:RUM_RS06460
uniprot id: D4LCW0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

213810:RUM RS06130
gene id: 213810:RUM_RS06130
uniprot id: D4LCQ5
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS10475
gene id: 213810:RUM_RS10475
uniprot id: D4LEY0
names: Similarity
messages: Belongs to the EamA transporter family.

213810:RUM RS11555
gene id: 213810:RUM_RS11555
uniprot id: D4LFH1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

213810:RUM RS03580
gene id: 213810:RUM_RS03580
uniprot id: D4LBE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

213810:RUM RS05595
gene id: 213810:RUM_RS05595
uniprot id: D4LCG4
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

213810:RUM RS03550
gene id: 213810:RUM_RS03550
uniprot id: D4LBE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

213810:RUM RS03055
gene id: 213810:RUM_RS03055
uniprot id: D4LB53
names: Similarity
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

213810:RUM RS04175
gene id: 213810:RUM_RS04175
uniprot id: D4LBP7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

213810:RUM RS09430
gene id: 213810:RUM_RS09430
uniprot id: D4LED6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

213810:RUM RS04040
gene id: 213810:RUM_RS04040
uniprot id: D4LBM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

213810:RUM RS05580
gene id: 213810:RUM_RS05580
uniprot id: D4LCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

213810:RUM RS02055
gene id: 213810:RUM_RS02055
uniprot id: D4LAL3
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

213810:RUM RS03400
gene id: 213810:RUM_RS03400
uniprot id: D4LBB4
names: Similarity
messages: Belongs to the CapA family.

213810:RUM RS09050
gene id: 213810:RUM_RS09050
uniprot id: D4LE65
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS05200
gene id: 213810:RUM_RS05200
uniprot id: D4LC92
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

213810:RUM RS02045
gene id: 213810:RUM_RS02045
uniprot id: D4LAL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

213810:RUM RS06285
gene id: 213810:RUM_RS06285
uniprot id: D4LCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

213810:RUM RS04435
gene id: 213810:RUM_RS04435
uniprot id: D4LBU9
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS06045
gene id: 213810:RUM_RS06045
uniprot id: D4LCP2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

213810:RUM RS05905
gene id: 213810:RUM_RS05905
uniprot id: D4LCL6
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS08080
gene id: 213810:RUM_RS08080
uniprot id: D4LDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

213810:RUM RS09265
gene id: 213810:RUM_RS09265
uniprot id: D4LEA7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

213810:RUM RS09080
gene id: 213810:RUM_RS09080
uniprot id: D4LE71
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS10160
gene id: 213810:RUM_RS10160
uniprot id: D4LES0
names: Subcellular Location Annotation
messages: Membrane

213810:RUM RS07460
gene id: 213810:RUM_RS07460
uniprot id: D4LDD0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

213810:RUM RS00545
gene id: 213810:RUM_RS00545
uniprot id: D4L9T5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

213810:RUM RS09915
gene id: 213810:RUM_RS09915
uniprot id: D4LEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

213810:RUM RS09345
gene id: 213810:RUM_RS09345
uniprot id: D4LEC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

213810:RUM RS03590
gene id: 213810:RUM_RS03590
uniprot id: D4LBE6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS11525
gene id: 213810:RUM_RS11525
uniprot id: D4LFG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

213810:RUM RS01440
gene id: 213810:RUM_RS01440
uniprot id: D4LA97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

213810:RUM RS05990
gene id: 213810:RUM_RS05990
uniprot id: D4LCN2
names: Similarity
messages: Belongs to the PemK/MazF family.

213810:RUM RS05620
gene id: 213810:RUM_RS05620
uniprot id: D4LCH0
names: Similarity
messages: Belongs to the citrate synthase family.

213810:RUM RS09555
gene id: 213810:RUM_RS09555
uniprot id: D4LEF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

213810:RUM RS00935
gene id: 213810:RUM_RS00935
uniprot id: D4LA06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

213810:RUM RS11485
gene id: 213810:RUM_RS11485
uniprot id: D4LFF7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

213810:RUM RS00165
gene id: 213810:RUM_RS00165
uniprot id: D4L9M2
names: Similarity
messages: Belongs to the peptidase M18 family.

213810:RUM RS03200
gene id: 213810:RUM_RS03200
uniprot id: D4LB80
names: Similarity
messages: Belongs to the RecJ family.

213810:RUM RS01950
gene id: 213810:RUM_RS01950
uniprot id: D4LAJ2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

213810:RUM RS03035
gene id: 213810:RUM_RS03035
uniprot id: D4LB51
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

213810:RUM RS05365
gene id: 213810:RUM_RS05365
uniprot id: D4LCC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.