204722:BR RS10975
gene id: 204722:BR_RS10975
uniprot id: Q8FX81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

204722:BR RS13645
gene id: 204722:BR_RS13645
uniprot id: A0A0H3GB59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

204722:BR RS01340
gene id: 204722:BR_RS01340
uniprot id: Q8G2N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

204722:BR RS01065
gene id: 204722:BR_RS01065
uniprot id: A0A0H3G9T7
names: Similarity
messages: Belongs to the GcvT family.

204722:BR RS02935
gene id: 204722:BR_RS02935
uniprot id: A0A0H3G5X4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS13250
gene id: 204722:BR_RS13250
uniprot id: A0A0H3G6T4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS02810
gene id: 204722:BR_RS02810
uniprot id: Q8G1U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

204722:BR RS04595
gene id: 204722:BR_RS04595
uniprot id: Q8G0U3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

204722:BR RS02175
gene id: 204722:BR_RS02175
uniprot id: Q8G261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

204722:BR RS14595
gene id: 204722:BR_RS14595
uniprot id: A0A0H3GC38
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

204722:BR RS01780
gene id: 204722:BR_RS01780
uniprot id: A0A0H3G5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

204722:BR RS04295
gene id: 204722:BR_RS04295
uniprot id: A0A0H3G2Z1
names: Function
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.

204722:BR RS00605
gene id: 204722:BR_RS00605
uniprot id: A0A0H3G5D4
names: Similarity
messages: Belongs to the FrmR/RcnR family.

204722:BR RS09835
gene id: 204722:BR_RS09835
uniprot id: A0A0H3G5X8
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

204722:BR RS05180
gene id: 204722:BR_RS05180
uniprot id: A0A0H3G391
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

204722:BR RS09080
gene id: 204722:BR_RS09080
uniprot id: A0A0H3G5M4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.

204722:BR RS07125
gene id: 204722:BR_RS07125
uniprot id: A0A0H3G806
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

204722:BR RS05640
gene id: 204722:BR_RS05640
uniprot id: Q8G088
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

204722:BR RS01025
gene id: 204722:BR_RS01025
uniprot id: A0A0H3G1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS10405
gene id: 204722:BR_RS10405
uniprot id: A0A0H3G668
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

204722:BR RS10350
gene id: 204722:BR_RS10350
uniprot id: Q7CEG3
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the virB8 family.
messages: Cell inner membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS03550
gene id: 204722:BR_RS03550
uniprot id: Q8G1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

204722:BR RS12565
gene id: 204722:BR_RS12565
uniprot id: A0A0H3G6H5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

204722:BR RS13025
gene id: 204722:BR_RS13025
uniprot id: A0A0H3G6N9
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

204722:BR RS16565
gene id: 204722:BR_RS16565
uniprot id: P66287
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

204722:BR RS08965
gene id: 204722:BR_RS08965
uniprot id: A0A0H3G8V3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

204722:BR RS08230
gene id: 204722:BR_RS08230
uniprot id: A0A0H3G570
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS06605
gene id: 204722:BR_RS06605
uniprot id: P65469
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

204722:BR RS05345
gene id: 204722:BR_RS05345
uniprot id: Q8G0E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

204722:BR RS06915
gene id: 204722:BR_RS06915
uniprot id: A0A0H3G4K7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS09795
gene id: 204722:BR_RS09795
uniprot id: Q8FXX1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

204722:BR RS00130
gene id: 204722:BR_RS00130
uniprot id: A0A0H3G548
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

204722:BR RS00895
gene id: 204722:BR_RS00895
uniprot id: A0A0H3G5J0
names: Function
names: Similarity
names: Subunit
messages: APS kinase catalyzes the synthesis of activated sulfate.
messages: Belongs to the APS kinase family.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Catalyzes the synthesis of activated sulfate.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Proposed to provide activated sulfate for transfer to Nod factor. ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity.
messages: Sulfate-activating enzymes, NodP and NodQ, may be physically associated.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

204722:BR RS09350
gene id: 204722:BR_RS09350
uniprot id: A0A0H3G5R6
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS01905
gene id: 204722:BR_RS01905
uniprot id: A0A0H3GA72
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS10700
gene id: 204722:BR_RS10700
uniprot id: A0A0H3GA53
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04200
gene id: 204722:BR_RS04200
uniprot id: A0A0H3G773
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

204722:BR RS14290
gene id: 204722:BR_RS14290
uniprot id: A0A0H3GFZ0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

204722:BR RS09320
gene id: 204722:BR_RS09320
uniprot id: A0A0H3G915
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family. Hemolysin C subfamily.
messages: Membrane

204722:BR RS03740
gene id: 204722:BR_RS03740
uniprot id: Q8G1B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

204722:BR RS14655
gene id: 204722:BR_RS14655
uniprot id: A0A0H3GG50
names: Similarity
messages: Belongs to the creatininase superfamily.

204722:BR RS00275
gene id: 204722:BR_RS00275
uniprot id: A0A0H3G4M6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS01650
gene id: 204722:BR_RS01650
uniprot id: A0A0H3G1W0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

204722:BR RS14565
gene id: 204722:BR_RS14565
uniprot id: P66515
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

204722:BR RS09535
gene id: 204722:BR_RS09535
uniprot id: A0A0H3G5U1
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

204722:BR RS03000
gene id: 204722:BR_RS03000
uniprot id: Q8G1Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

204722:BR RS09965
gene id: 204722:BR_RS09965
uniprot id: Q8FXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

204722:BR RS03470
gene id: 204722:BR_RS03470
uniprot id: P67013
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS15195
gene id: 204722:BR_RS15195
uniprot id: A0A0H3GCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS00390
gene id: 204722:BR_RS00390
uniprot id: A0A0H3G1D1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

204722:BR RS13200
gene id: 204722:BR_RS13200
uniprot id: A0A0H3G6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

204722:BR RS10480
gene id: 204722:BR_RS10480
uniprot id: A0A0H3G678
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

204722:BR RS04680
gene id: 204722:BR_RS04680
uniprot id: A0A0H3G329
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Maintains high levels of reduced glutathione.

204722:BR RS07530
gene id: 204722:BR_RS07530
uniprot id: A0A0H3G8Q7
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14035
gene id: 204722:BR_RS14035
uniprot id: A0A0H3G7U7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

204722:BR RS02125
gene id: 204722:BR_RS02125
uniprot id: A0A0H3GAA3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

204722:BR RS06470
gene id: 204722:BR_RS06470
uniprot id: A0A0H3G7Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS08435
gene id: 204722:BR_RS08435
uniprot id: Q8FYM9
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

204722:BR RS03915
gene id: 204722:BR_RS03915
uniprot id: A0A0H3GB83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

204722:BR RS09385
gene id: 204722:BR_RS09385
uniprot id: A0A0H3G4Y9
names: Similarity
messages: Belongs to the Gfa family.

204722:BR RS05765
gene id: 204722:BR_RS05765
uniprot id: P0A469
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

204722:BR RS15660
gene id: 204722:BR_RS15660
uniprot id: Q8FUN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably Responsible for energy coupling to the transport system (Probable).
messages: The complex is composed of two ATP-binding proteins (BRA1187), two transmembrane proteins (BRA1188) and a solute-binding protein (BRA1186).

204722:BR RS09805
gene id: 204722:BR_RS09805
uniprot id: Q8FXW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

204722:BR RS06985
gene id: 204722:BR_RS06985
uniprot id: A0A0H3G8G5
names: Subcellular Location Annotation
messages: Cytoplasm

204722:BR RS05275
gene id: 204722:BR_RS05275
uniprot id: A0A0H3G3B9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

204722:BR RS14095
gene id: 204722:BR_RS14095
uniprot id: A0A0H3GBW4
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

204722:BR RS13715
gene id: 204722:BR_RS13715
uniprot id: A0A0H3GFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS12685
gene id: 204722:BR_RS12685
uniprot id: Q8FW95
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

204722:BR RS01915
gene id: 204722:BR_RS01915
uniprot id: Q8G2B1
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

204722:BR RS15160
gene id: 204722:BR_RS15160
uniprot id: Q8FUW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA1094), two transmembrane proteins (BRA1092 and BRA1093) and a solute-binding protein (BRA1090).

204722:BR RS04835
gene id: 204722:BR_RS04835
uniprot id: Q8G0P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell inner membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

204722:BR RS14790
gene id: 204722:BR_RS14790
uniprot id: A0A0H3GC66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS10435
gene id: 204722:BR_RS10435
uniprot id: A0A0H3G9Z8
names: Function
messages: Acts on leucine, isoleucine and valine.

204722:BR RS05555
gene id: 204722:BR_RS05555
uniprot id: A0A0H3G7W5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

204722:BR RS14240
gene id: 204722:BR_RS14240
uniprot id: Q8FVE4
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family.
messages: Catalyzes the conversion of L-ornithine into L-proline with release of ammonia.

204722:BR RS09520
gene id: 204722:BR_RS09520
uniprot id: Q8FY22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

204722:BR RS01600
gene id: 204722:BR_RS01600
uniprot id: A0A0H3G1V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

204722:BR RS05240
gene id: 204722:BR_RS05240
uniprot id: A0A0H3G396
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

204722:BR RS08335
gene id: 204722:BR_RS08335
uniprot id: Q8FYQ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

204722:BR RS10340
gene id: 204722:BR_RS10340
uniprot id: Q9RPX5
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Cell membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS06570
gene id: 204722:BR_RS06570
uniprot id: A0A0H3GCE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

204722:BR RS13790
gene id: 204722:BR_RS13790
uniprot id: Q8FVM9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
messages: Cell inner membrane
messages: Induced by low oxygen tension and metal ion deficiency. Repressed by NiCl(2) excess.
messages: Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).

204722:BR RS08240
gene id: 204722:BR_RS08240
uniprot id: Q8FYS0
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Displays no proline racemase activity.
messages: Belongs to the proline racemase family.
messages: Homodimer.
messages: Inhibited by iodoacetate, iodoacetamide and by high amounts (10 mM) of pyrrole-2-carboxylic acid (PYC). Not inhibited by PYC at 1 mM.
messages: This enzyme does not require pyridoxal phosphate (PLP) as a cofactor.

204722:BR RS01170
gene id: 204722:BR_RS01170
uniprot id: Q8G2R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

204722:BR RS09870
gene id: 204722:BR_RS09870
uniprot id: A0A0H3G538
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

204722:BR RS02415
gene id: 204722:BR_RS02415
uniprot id: A0A0H3G6C6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS08120
gene id: 204722:BR_RS08120
uniprot id: Q8FYU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

204722:BR RS03020
gene id: 204722:BR_RS03020
uniprot id: A0A0H3GAS8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

204722:BR RS08740
gene id: 204722:BR_RS08740
uniprot id: A0A0H3G996
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

204722:BR RS09655
gene id: 204722:BR_RS09655
uniprot id: Q8FXZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

204722:BR RS07805
gene id: 204722:BR_RS07805
uniprot id: A0A0H3G8C2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

204722:BR RS14140
gene id: 204722:BR_RS14140
uniprot id: A0A0H3GFX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

204722:BR RS15120
gene id: 204722:BR_RS15120
uniprot id: A0A0H3G8D7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

204722:BR RS08020
gene id: 204722:BR_RS08020
uniprot id: A0A0H3G529
names: Similarity
messages: Belongs to the thioesterase PaaI family.

204722:BR RS14080
gene id: 204722:BR_RS14080
uniprot id: A0A0H3GFW7
names: Similarity
messages: Belongs to the FGGY kinase family.

204722:BR RS01465
gene id: 204722:BR_RS01465
uniprot id: Q8G2K8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

204722:BR RS07075
gene id: 204722:BR_RS07075
uniprot id: Q8FZF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

204722:BR RS13380
gene id: 204722:BR_RS13380
uniprot id: A0A0H3G6V9
names: Similarity
messages: Belongs to the TPP enzyme family.

204722:BR RS01295
gene id: 204722:BR_RS01295
uniprot id: A0A0H3G5Q5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS13120
gene id: 204722:BR_RS13120
uniprot id: Q8FW09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

204722:BR RS15390
gene id: 204722:BR_RS15390
uniprot id: A0A0H3GCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

204722:BR RS13980
gene id: 204722:BR_RS13980
uniprot id: A0A0H3GBR5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

204722:BR RS08870
gene id: 204722:BR_RS08870
uniprot id: P66868
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

204722:BR RS10185
gene id: 204722:BR_RS10185
uniprot id: Q8FXP1
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS01480
gene id: 204722:BR_RS01480
uniprot id: A0A0H3G5T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

204722:BR RS00430
gene id: 204722:BR_RS00430
uniprot id: A0A0H3G9H5
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

204722:BR RS15625
gene id: 204722:BR_RS15625
uniprot id: A0A0H3G8K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

204722:BR RS06550
gene id: 204722:BR_RS06550
uniprot id: A0A0H3G7S3
names: Similarity
messages: Belongs to the peptidase M24B family.

204722:BR RS04650
gene id: 204722:BR_RS04650
uniprot id: A0A0H3GBK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Homotrimer.
messages: In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed.

204722:BR RS05175
gene id: 204722:BR_RS05175
uniprot id: A0A0H3GBT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

204722:BR RS11635
gene id: 204722:BR_RS11635
uniprot id: A0A0H3GAQ1
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

204722:BR RS00165
gene id: 204722:BR_RS00165
uniprot id: A0A0H3G4K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

204722:BR RS08820
gene id: 204722:BR_RS08820
uniprot id: P66652
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

204722:BR RS05935
gene id: 204722:BR_RS05935
uniprot id: A0A0H3G480
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

204722:BR RS06155
gene id: 204722:BR_RS06155
uniprot id: A0A0H3G3J7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

204722:BR RS11055
gene id: 204722:BR_RS11055
uniprot id: P65326
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

204722:BR RS13130
gene id: 204722:BR_RS13130
uniprot id: Q8FW07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

204722:BR RS02220
gene id: 204722:BR_RS02220
uniprot id: Q8G253
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

204722:BR RS13075
gene id: 204722:BR_RS13075
uniprot id: A0A0H3G6Q2
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family.

204722:BR RS15190
gene id: 204722:BR_RS15190
uniprot id: A0A0H3GBX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS10070
gene id: 204722:BR_RS10070
uniprot id: P66502
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

204722:BR RS13860
gene id: 204722:BR_RS13860
uniprot id: Q8FVM2
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

204722:BR RS09140
gene id: 204722:BR_RS09140
uniprot id: A0A0H3G5N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

204722:BR RS00505
gene id: 204722:BR_RS00505
uniprot id: A0A0H3G1D5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

204722:BR RS11210
gene id: 204722:BR_RS11210
uniprot id: A0A0H3GAE5
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

204722:BR RS08270
gene id: 204722:BR_RS08270
uniprot id: Q8FYR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

204722:BR RS13145
gene id: 204722:BR_RS13145
uniprot id: A0A0H3G7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

204722:BR RS01920
gene id: 204722:BR_RS01920
uniprot id: A0A0H3G200
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

204722:BR RS14780
gene id: 204722:BR_RS14780
uniprot id: A0A0H3G7N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS05770
gene id: 204722:BR_RS05770
uniprot id: Q8G067
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

204722:BR RS02610
gene id: 204722:BR_RS02610
uniprot id: A0A0H3G6F7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

204722:BR RS02955
gene id: 204722:BR_RS02955
uniprot id: P0DI95
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alphaproteobacteria porin family.
messages: Cell outer membrane
messages: Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.
messages: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
messages: Homotrimer.
messages: The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.

204722:BR RS00935
gene id: 204722:BR_RS00935
uniprot id: A0A0H3G1L1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS01500
gene id: 204722:BR_RS01500
uniprot id: A0A0H3G555
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

204722:BR RS05775
gene id: 204722:BR_RS05775
uniprot id: Q8G066
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

204722:BR RS09585
gene id: 204722:BR_RS09585
uniprot id: P64367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

204722:BR RS05105
gene id: 204722:BR_RS05105
uniprot id: A0A0H3G7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS09000
gene id: 204722:BR_RS09000
uniprot id: A0A0H3G9C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS03705
gene id: 204722:BR_RS03705
uniprot id: A0A0H3GB49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS08620
gene id: 204722:BR_RS08620
uniprot id: Q8FYK0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

204722:BR RS09760
gene id: 204722:BR_RS09760
uniprot id: P66266
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

204722:BR RS04670
gene id: 204722:BR_RS04670
uniprot id: Q8G0S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

204722:BR RS11650
gene id: 204722:BR_RS11650
uniprot id: A0A0H3G638
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03195
gene id: 204722:BR_RS03195
uniprot id: A0A0H3GAV5
names: Similarity
messages: Belongs to the DinB family.

204722:BR RS04440
gene id: 204722:BR_RS04440
uniprot id: A0A0H3G307
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

204722:BR RS08750
gene id: 204722:BR_RS08750
uniprot id: A0A0H3GDE8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

204722:BR RS13400
gene id: 204722:BR_RS13400
uniprot id: Q8FVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).

204722:BR RS07220
gene id: 204722:BR_RS07220
uniprot id: A0A0H3G3Y9
names: Similarity
messages: Belongs to the OmpW/AlkL family.

204722:BR RS03145
gene id: 204722:BR_RS03145
uniprot id: Q8G1N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

204722:BR RS04375
gene id: 204722:BR_RS04375
uniprot id: Q8G0Y3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

204722:BR RS05880
gene id: 204722:BR_RS05880
uniprot id: A0A0H3G470
names: Similarity
messages: Belongs to the RecJ family.

204722:BR RS06230
gene id: 204722:BR_RS06230
uniprot id: A0A0H3G7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

204722:BR RS11295
gene id: 204722:BR_RS11295
uniprot id: A0A0H3G5X1
names: Similarity
messages: Belongs to the FGGY kinase family.

204722:BR RS06320
gene id: 204722:BR_RS06320
uniprot id: A0A0H3G846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

204722:BR RS09180
gene id: 204722:BR_RS09180
uniprot id: P65745
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

204722:BR RS09025
gene id: 204722:BR_RS09025
uniprot id: A0A0H3G9D1
names: Similarity
messages: Belongs to the asparaginase 1 family.

204722:BR RS05695
gene id: 204722:BR_RS05695
uniprot id: Q8G080
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

204722:BR RS02335
gene id: 204722:BR_RS02335
uniprot id: A0A0H3G268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

204722:BR RS11215
gene id: 204722:BR_RS11215
uniprot id: Q8FX38
names: Function
messages: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection.

204722:BR RS03520
gene id: 204722:BR_RS03520
uniprot id: Q8G1F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS01980
gene id: 204722:BR_RS01980
uniprot id: A0A0H3G208
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

204722:BR RS08095
gene id: 204722:BR_RS08095
uniprot id: A0A0H3G8Z3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS10760
gene id: 204722:BR_RS10760
uniprot id: A0A0H3G9M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

204722:BR RS14145
gene id: 204722:BR_RS14145
uniprot id: A0A0H3GBH2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

204722:BR RS15580
gene id: 204722:BR_RS15580
uniprot id: A0A0H3GGG2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS06625
gene id: 204722:BR_RS06625
uniprot id: P64256
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

204722:BR RS12055
gene id: 204722:BR_RS12055
uniprot id: A0A0H3GAC8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14890
gene id: 204722:BR_RS14890
uniprot id: P64133
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

204722:BR RS05285
gene id: 204722:BR_RS05285
uniprot id: A0A0H3G786
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

204722:BR RS01250
gene id: 204722:BR_RS01250
uniprot id: Q8G2Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS12025
gene id: 204722:BR_RS12025
uniprot id: P0A3U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Omp25/RopB family.
messages: Cell outer membrane
messages: Major outer membrane protein associated with peptidoglycans. May function as a porin.
messages: Oligomeric.

204722:BR RS11460
gene id: 204722:BR_RS11460
uniprot id: A0A0H3GEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS11855
gene id: 204722:BR_RS11855
uniprot id: Q8FWQ3
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS06455
gene id: 204722:BR_RS06455
uniprot id: A0A0H3GCC8
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

204722:BR RS13885
gene id: 204722:BR_RS13885
uniprot id: A0A0H3G750
names: Similarity
messages: Belongs to the UPF0166 family.

204722:BR RS04985
gene id: 204722:BR_RS04985
uniprot id: A0A0H3G369
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS02135
gene id: 204722:BR_RS02135
uniprot id: A0A0H3G5H4
names: Similarity
messages: Belongs to the YicC/YloC family.

204722:BR RS01710
gene id: 204722:BR_RS01710
uniprot id: A0A0H3G1Z1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS09005
gene id: 204722:BR_RS09005
uniprot id: A0A0H3G5K9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS05280
gene id: 204722:BR_RS05280
uniprot id: Q8G0F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

204722:BR RS05745
gene id: 204722:BR_RS05745
uniprot id: P63194
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

204722:BR RS14690
gene id: 204722:BR_RS14690
uniprot id: A0A0H3GG56
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10285
gene id: 204722:BR_RS10285
uniprot id: A0A0H3G9Y1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

204722:BR RS00125
gene id: 204722:BR_RS00125
uniprot id: Q8G3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

204722:BR RS00645
gene id: 204722:BR_RS00645
uniprot id: A0A0H3G9L2
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS10580
gene id: 204722:BR_RS10580
uniprot id: A0A0H3G5F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

204722:BR RS09595
gene id: 204722:BR_RS09595
uniprot id: Q8FY09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

204722:BR RS07755
gene id: 204722:BR_RS07755
uniprot id: P64005
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

204722:BR RS06615
gene id: 204722:BR_RS06615
uniprot id: A0A0H3GCF1
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08680
gene id: 204722:BR_RS08680
uniprot id: A0A0H3GDE1
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

204722:BR RS01665
gene id: 204722:BR_RS01665
uniprot id: A0A0H3G1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

204722:BR RS09790
gene id: 204722:BR_RS09790
uniprot id: Q8FXX2
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

204722:BR RS06410
gene id: 204722:BR_RS06410
uniprot id: A0A0H3G3M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

204722:BR RS12120
gene id: 204722:BR_RS12120
uniprot id: A0A0H3G6A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

204722:BR RS09715
gene id: 204722:BR_RS09715
uniprot id: P67004
names: Similarity
messages: Belongs to the TrpF family.

204722:BR RS08115
gene id: 204722:BR_RS08115
uniprot id: Q8FYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

204722:BR RS10875
gene id: 204722:BR_RS10875
uniprot id: A0A0H3G6E4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS00745
gene id: 204722:BR_RS00745
uniprot id: A0A0H3G9M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

204722:BR RS00785
gene id: 204722:BR_RS00785
uniprot id: A0A0H3G9N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

204722:BR RS15090
gene id: 204722:BR_RS15090
uniprot id: A0A0H3G8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS00665
gene id: 204722:BR_RS00665
uniprot id: A0A0H3G5E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

204722:BR RS02340
gene id: 204722:BR_RS02340
uniprot id: P59284
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ureidoglycolate lyase family.
messages: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
messages: Homodimer.

204722:BR RS06310
gene id: 204722:BR_RS06310
uniprot id: A0A0H3G3L5
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS15345
gene id: 204722:BR_RS15345
uniprot id: Q8FUU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Part of the ATP-binding cassette (ABC) transport system ZnuABC involved in zinc import (By similarity). Binds zinc with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm (By similarity). Required for survival and normal growth under low Zn (2+) concentrations (By similarity). Also required for virulence and intracellular growth in host cells (By similarity).
messages: Periplasm

204722:BR RS09355
gene id: 204722:BR_RS09355
uniprot id: A0A0H3GDN2
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

204722:BR RS13280
gene id: 204722:BR_RS13280
uniprot id: P61713
names: Function
names: Induction
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: The two ribH genes may be differentially expressed during the Brucella infection cycle. Brucella would use RibH1 for flavin biosynthesis during the extracellular phase and RibH2 during intracellular growth (By similarity).

204722:BR RS08530
gene id: 204722:BR_RS08530
uniprot id: A0A0H3G5D6
names: Function
messages: Involved in the transposition of the insertion sequence.

204722:BR RS13080
gene id: 204722:BR_RS13080
uniprot id: Q8FW17
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS10775
gene id: 204722:BR_RS10775
uniprot id: A0A0H3G6C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

204722:BR RS05040
gene id: 204722:BR_RS05040
uniprot id: A0A0H3G3T5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS12550
gene id: 204722:BR_RS12550
uniprot id: A0A0H3G6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS01615
gene id: 204722:BR_RS01615
uniprot id: A0A0H3G1X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide deacetylase family.
messages: Cytoplasm
messages: Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.

204722:BR RS03435
gene id: 204722:BR_RS03435
uniprot id: A0A0H3G2N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS02985
gene id: 204722:BR_RS02985
uniprot id: P66859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

204722:BR RS02105
gene id: 204722:BR_RS02105
uniprot id: Q8G274
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

204722:BR RS14120
gene id: 204722:BR_RS14120
uniprot id: Q8FVG9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

204722:BR RS06445
gene id: 204722:BR_RS06445
uniprot id: A0A0H3G868
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

204722:BR RS02400
gene id: 204722:BR_RS02400
uniprot id: A0A0H3GAG6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS03480
gene id: 204722:BR_RS03480
uniprot id: A0A0H3GB12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

204722:BR RS05075
gene id: 204722:BR_RS05075
uniprot id: P65949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

204722:BR RS06250
gene id: 204722:BR_RS06250
uniprot id: A0A0H3G7M0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

204722:BR RS08760
gene id: 204722:BR_RS08760
uniprot id: A0A0H3G8T2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.

204722:BR RS02075
gene id: 204722:BR_RS02075
uniprot id: A0A0H3G5G2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

204722:BR RS14070
gene id: 204722:BR_RS14070
uniprot id: A0A0H3G7B6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS02535
gene id: 204722:BR_RS02535
uniprot id: Q8G1Z9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Binds 2 potassium ions per subunit.
messages: Dimer of dimers.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

204722:BR RS09860
gene id: 204722:BR_RS09860
uniprot id: P63362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

204722:BR RS10225
gene id: 204722:BR_RS10225
uniprot id: A0A0H3G594
names: Function
names: Subunit
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

204722:BR RS11390
gene id: 204722:BR_RS11390
uniprot id: A0A0H3GEN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

204722:BR RS09910
gene id: 204722:BR_RS09910
uniprot id: Q8FXU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

204722:BR RS05310
gene id: 204722:BR_RS05310
uniprot id: Q8G0F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

204722:BR RS06165
gene id: 204722:BR_RS06165
uniprot id: A0A0H3G825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

204722:BR RS07120
gene id: 204722:BR_RS07120
uniprot id: A0A0H3G3X7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

204722:BR RS10000
gene id: 204722:BR_RS10000
uniprot id: A0A0H3GDX0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

204722:BR RS13175
gene id: 204722:BR_RS13175
uniprot id: A0A0H3GFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

204722:BR RS14935
gene id: 204722:BR_RS14935
uniprot id: A0A0H3G8A9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

204722:BR RS14950
gene id: 204722:BR_RS14950
uniprot id: P0A3Q3
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

204722:BR RS03910
gene id: 204722:BR_RS03910
uniprot id: A0A0H3G370
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

204722:BR RS14875
gene id: 204722:BR_RS14875
uniprot id: Q8FV22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

204722:BR RS00940
gene id: 204722:BR_RS00940
uniprot id: A0A0H3G9R2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

204722:BR RS09200
gene id: 204722:BR_RS09200
uniprot id: A0A0H3G5N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

204722:BR RS02000
gene id: 204722:BR_RS02000
uniprot id: A0A0H3G229
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

204722:BR RS01785
gene id: 204722:BR_RS01785
uniprot id: Q8G2D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

204722:BR RS02495
gene id: 204722:BR_RS02495
uniprot id: A0A0H3G2F2
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14660
gene id: 204722:BR_RS14660
uniprot id: A0A0H3G7L4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

204722:BR RS02115
gene id: 204722:BR_RS02115
uniprot id: A0A0H3G648
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

204722:BR RS04590
gene id: 204722:BR_RS04590
uniprot id: A0A0H3G3K5
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

204722:BR RS02045
gene id: 204722:BR_RS02045
uniprot id: A0A0H3G215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

204722:BR RS13675
gene id: 204722:BR_RS13675
uniprot id: A0A0H3G722
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

204722:BR RS06920
gene id: 204722:BR_RS06920
uniprot id: A0A0H3GCJ9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

204722:BR RS00685
gene id: 204722:BR_RS00685
uniprot id: Q8G310
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

204722:BR RS15430
gene id: 204722:BR_RS15430
uniprot id: Q8FUS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.

204722:BR RS05990
gene id: 204722:BR_RS05990
uniprot id: A0A0H3G490
names: Function
messages: Component of an amino-acid transport system.

204722:BR RS10375
gene id: 204722:BR_RS10375
uniprot id: Q7CEG1
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the virB3 family.
messages: Cell membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS03160
gene id: 204722:BR_RS03160
uniprot id: A0A0H3G6P0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS07305
gene id: 204722:BR_RS07305
uniprot id: A0A0H3G835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS09995
gene id: 204722:BR_RS09995
uniprot id: A0A0H3G604
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

204722:BR RS12130
gene id: 204722:BR_RS12130
uniprot id: A0A0H3GAE2
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08350
gene id: 204722:BR_RS08350
uniprot id: P67540
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

204722:BR RS08860
gene id: 204722:BR_RS08860
uniprot id: Q8FYF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

204722:BR RS08615
gene id: 204722:BR_RS08615
uniprot id: A0A0H3G8R4
names: Similarity
messages: Belongs to the aspartokinase family.

204722:BR RS13595
gene id: 204722:BR_RS13595
uniprot id: Q8FVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

204722:BR RS07110
gene id: 204722:BR_RS07110
uniprot id: P63543
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS10560
gene id: 204722:BR_RS10560
uniprot id: A0A0H3G9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the O-antigen polymerase family.
messages: Membrane

204722:BR RS13275
gene id: 204722:BR_RS13275
uniprot id: Q8FVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of a binding-protein-dependent transport system for a sugar.
messages: Periplasm

204722:BR RS10955
gene id: 204722:BR_RS10955
uniprot id: Q8FX87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

204722:BR RS02210
gene id: 204722:BR_RS02210
uniprot id: A0A0H3G238
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

204722:BR RS01940
gene id: 204722:BR_RS01940
uniprot id: A0A0H3GA76
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

204722:BR RS13690
gene id: 204722:BR_RS13690
uniprot id: A0A0H3GB64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

204722:BR RS15410
gene id: 204722:BR_RS15410
uniprot id: Q8FUT3
names: Caution
names: Function
names: Similarity
messages: Belongs to the FlbT family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.
messages: Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation.

204722:BR RS05735
gene id: 204722:BR_RS05735
uniprot id: Q8G075
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

204722:BR RS11195
gene id: 204722:BR_RS11195
uniprot id: A0A0H3GEH0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10585
gene id: 204722:BR_RS10585
uniprot id: A0A0H3G9J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS05605
gene id: 204722:BR_RS05605
uniprot id: P66351
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

204722:BR RS00965
gene id: 204722:BR_RS00965
uniprot id: A0A0H3G9R8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS10740
gene id: 204722:BR_RS10740
uniprot id: A0A0H3GA65
names: Similarity
messages: Belongs to the hyi family.

204722:BR RS01755
gene id: 204722:BR_RS01755
uniprot id: Q8G2E8
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

204722:BR RS02765
gene id: 204722:BR_RS02765
uniprot id: A0A0H3G2E5
names: Similarity
messages: Belongs to the peptidase C40 family.

204722:BR RS13750
gene id: 204722:BR_RS13750
uniprot id: A0A0H3G733
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

204722:BR RS09855
gene id: 204722:BR_RS09855
uniprot id: A0A0H3G5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS09685
gene id: 204722:BR_RS09685
uniprot id: A0A0H3G964
names: Similarity
messages: Belongs to the thioredoxin family.

204722:BR RS09510
gene id: 204722:BR_RS09510
uniprot id: Q8FY24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS11520
gene id: 204722:BR_RS11520
uniprot id: A0A0H3GEQ5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

204722:BR RS05655
gene id: 204722:BR_RS05655
uniprot id: P66400
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

204722:BR RS15730
gene id: 204722:BR_RS15730
uniprot id: A0A0H3G7Z3
names: Similarity
messages: Belongs to the ParB family.

204722:BR RS05700
gene id: 204722:BR_RS05700
uniprot id: P66490
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

204722:BR RS15045
gene id: 204722:BR_RS15045
uniprot id: Q8FUZ1
names: Similarity
messages: Belongs to the SlyX family.

204722:BR RS07680
gene id: 204722:BR_RS07680
uniprot id: A0A0H3G459
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

204722:BR RS01325
gene id: 204722:BR_RS01325
uniprot id: A0A0H3G1S0
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

204722:BR RS00270
gene id: 204722:BR_RS00270
uniprot id: A0A0H3G9F1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

204722:BR RS04335
gene id: 204722:BR_RS04335
uniprot id: Q8G0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

204722:BR RS09010
gene id: 204722:BR_RS09010
uniprot id: A0A0H3GDI1
names: Similarity
messages: Belongs to the arginase family.

204722:BR RS05430
gene id: 204722:BR_RS05430
uniprot id: Q8G0C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

204722:BR RS11030
gene id: 204722:BR_RS11030
uniprot id: A0A0H3GAA5
names: Similarity
messages: Belongs to the peptidase U62 family.

204722:BR RS04090
gene id: 204722:BR_RS04090
uniprot id: P66880
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

204722:BR RS10795
gene id: 204722:BR_RS10795
uniprot id: A0A0H3G9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

204722:BR RS11800
gene id: 204722:BR_RS11800
uniprot id: A0A0H3GAS7
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

204722:BR RS14300
gene id: 204722:BR_RS14300
uniprot id: Q8FVD4
names: Similarity
messages: Belongs to the UPF0309 family.

204722:BR RS06830
gene id: 204722:BR_RS06830
uniprot id: Q8FZK4
names: Similarity
messages: Belongs to the UPF0260 family.

204722:BR RS05715
gene id: 204722:BR_RS05715
uniprot id: Q8G077
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

204722:BR RS12530
gene id: 204722:BR_RS12530
uniprot id: A0A0H3GAK7
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

204722:BR RS00790
gene id: 204722:BR_RS00790
uniprot id: Q8G2Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

204722:BR RS10815
gene id: 204722:BR_RS10815
uniprot id: A0A0H3G5K2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS02280
gene id: 204722:BR_RS02280
uniprot id: A0A0H3G280
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

204722:BR RS03660
gene id: 204722:BR_RS03660
uniprot id: A0A0H3G2R9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

204722:BR RS01875
gene id: 204722:BR_RS01875
uniprot id: A0A0H3G605
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

204722:BR RS09285
gene id: 204722:BR_RS09285
uniprot id: A0A0H3G9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

204722:BR RS01700
gene id: 204722:BR_RS01700
uniprot id: A0A0H3G1W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS12435
gene id: 204722:BR_RS12435
uniprot id: A0A0H3GF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS12690
gene id: 204722:BR_RS12690
uniprot id: Q8FW94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

204722:BR RS09495
gene id: 204722:BR_RS09495
uniprot id: A0A0H3G939
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rho family.
messages: Cell inner membrane
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS07240
gene id: 204722:BR_RS07240
uniprot id: A0A0H3G3Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
messages: Membrane

204722:BR RS05965
gene id: 204722:BR_RS05965
uniprot id: A0A0H3G486
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

204722:BR RS06990
gene id: 204722:BR_RS06990
uniprot id: A0A0H3GCL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport.
messages: Membrane

204722:BR RS03545
gene id: 204722:BR_RS03545
uniprot id: Q8G1E7
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

204722:BR RS13705
gene id: 204722:BR_RS13705
uniprot id: A0A0H3GBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS00795
gene id: 204722:BR_RS00795
uniprot id: P64397
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

204722:BR RS06860
gene id: 204722:BR_RS06860
uniprot id: Q8FZJ8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

204722:BR RS08855
gene id: 204722:BR_RS08855
uniprot id: A0A0H3GDF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

204722:BR RS03640
gene id: 204722:BR_RS03640
uniprot id: Q8G1C9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

204722:BR RS03885
gene id: 204722:BR_RS03885
uniprot id: Q8G178
names: Similarity
messages: Belongs to the SAICAR synthetase family.

204722:BR RS09120
gene id: 204722:BR_RS09120
uniprot id: Q8FYA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

204722:BR RS07295
gene id: 204722:BR_RS07295
uniprot id: A0A0H3GCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS10530
gene id: 204722:BR_RS10530
uniprot id: A0A0H3G686
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

204722:BR RS03830
gene id: 204722:BR_RS03830
uniprot id: P59128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

204722:BR RS01605
gene id: 204722:BR_RS01605
uniprot id: A0A0H3G580
names: Similarity
messages: Belongs to the bacterial solute-binding protein 7 family.

204722:BR RS05665
gene id: 204722:BR_RS05665
uniprot id: Q8G084
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

204722:BR RS10770
gene id: 204722:BR_RS10770
uniprot id: A0A0H3GA69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

204722:BR RS02605
gene id: 204722:BR_RS02605
uniprot id: A0A0H3G5S2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

204722:BR RS09625
gene id: 204722:BR_RS09625
uniprot id: Q8FY05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

204722:BR RS10755
gene id: 204722:BR_RS10755
uniprot id: A0A0H3G5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

204722:BR RS12505
gene id: 204722:BR_RS12505
uniprot id: A0A0H3G6G4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

204722:BR RS08340
gene id: 204722:BR_RS08340
uniprot id: A0A0H3G8N5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS08210
gene id: 204722:BR_RS08210
uniprot id: Q8FYS6
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS11640
gene id: 204722:BR_RS11640
uniprot id: A0A0H3G6U2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

204722:BR RS03465
gene id: 204722:BR_RS03465
uniprot id: A0A0H3G670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

204722:BR RS08775
gene id: 204722:BR_RS08775
uniprot id: Q8FYG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

204722:BR RS13415
gene id: 204722:BR_RS13415
uniprot id: A0A0H3GB19
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

204722:BR RS04070
gene id: 204722:BR_RS04070
uniprot id: P66888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

204722:BR RS09525
gene id: 204722:BR_RS09525
uniprot id: Q8FY21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

204722:BR RS09930
gene id: 204722:BR_RS09930
uniprot id: Q8FXT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane

204722:BR RS04085
gene id: 204722:BR_RS04085
uniprot id: Q8G139
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

204722:BR RS09575
gene id: 204722:BR_RS09575
uniprot id: Q8FY12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

204722:BR RS01260
gene id: 204722:BR_RS01260
uniprot id: Q8G2P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS06395
gene id: 204722:BR_RS06395
uniprot id: Q8FZT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

204722:BR RS12775
gene id: 204722:BR_RS12775
uniprot id: Q8FW78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

204722:BR RS14405
gene id: 204722:BR_RS14405
uniprot id: Q8FVB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

204722:BR RS08610
gene id: 204722:BR_RS08610
uniprot id: A0A0H3G4L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

204722:BR RS01095
gene id: 204722:BR_RS01095
uniprot id: A0A0H3G1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS08640
gene id: 204722:BR_RS08640
uniprot id: A0A0H3G4M0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

204722:BR RS12395
gene id: 204722:BR_RS12395
uniprot id: A0A0H3G6E3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS01195
gene id: 204722:BR_RS01195
uniprot id: P65453
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

204722:BR RS02290
gene id: 204722:BR_RS02290
uniprot id: A0A0H3G5J9
names: Function
names: Similarity
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: May be required for disulfide bond formation in some proteins.

204722:BR RS07880
gene id: 204722:BR_RS07880
uniprot id: P66743
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

204722:BR RS03515
gene id: 204722:BR_RS03515
uniprot id: A0A0H3G680
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS12175
gene id: 204722:BR_RS12175
uniprot id: A0A0H3GEZ5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

204722:BR RS00800
gene id: 204722:BR_RS00800
uniprot id: Q8G2Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

204722:BR RS04045
gene id: 204722:BR_RS04045
uniprot id: Q8G146
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

204722:BR RS03570
gene id: 204722:BR_RS03570
uniprot id: Q8G1E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

204722:BR RS13600
gene id: 204722:BR_RS13600
uniprot id: A0A0H3GBL2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS15665
gene id: 204722:BR_RS15665
uniprot id: Q8FUN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (Probable).
messages: The complex is composed of two ATP-binding proteins (BRA1187), two transmembrane proteins (BRA1188) and a solute-binding protein (BRA1186).

204722:BR RS02090
gene id: 204722:BR_RS02090
uniprot id: Q8G276
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

204722:BR RS12145
gene id: 204722:BR_RS12145
uniprot id: A0A0H3G703
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS14970
gene id: 204722:BR_RS14970
uniprot id: P59160
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

204722:BR RS00455
gene id: 204722:BR_RS00455
uniprot id: A0A0H3G1C4
names: Similarity
messages: Belongs to the thioredoxin family. DsbE subfamily.

204722:BR RS10090
gene id: 204722:BR_RS10090
uniprot id: A0A0H3GDY9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

204722:BR RS15550
gene id: 204722:BR_RS15550
uniprot id: A0A0H3GGF7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS10365
gene id: 204722:BR_RS10365
uniprot id: Q9RPY0
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the virb5 family.
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS06275
gene id: 204722:BR_RS06275
uniprot id: Q8FZW2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS15215
gene id: 204722:BR_RS15215
uniprot id: A0A0H3G7S9
names: Similarity
messages: Belongs to the amidase family.

204722:BR RS07825
gene id: 204722:BR_RS07825
uniprot id: A0A0H3GCZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

204722:BR RS03490
gene id: 204722:BR_RS03490
uniprot id: A0A0H3G2P8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05380
gene id: 204722:BR_RS05380
uniprot id: Q8G0D7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

204722:BR RS02345
gene id: 204722:BR_RS02345
uniprot id: Q8G228
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

204722:BR RS13525
gene id: 204722:BR_RS13525
uniprot id: Q8FVS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm
messages: Probably part of an ABC transporter complex.
messages: The complex is composed of two ATP-binding proteins (BRA0745), two transmembrane proteins (BRA0749) and a solute-binding protein (BRA0748).

204722:BR RS14960
gene id: 204722:BR_RS14960
uniprot id: A0A0H3GBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

204722:BR RS14720
gene id: 204722:BR_RS14720
uniprot id: A0A0H3G7M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

204722:BR RS05730
gene id: 204722:BR_RS05730
uniprot id: P64025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

204722:BR RS13535
gene id: 204722:BR_RS13535
uniprot id: A0A0H3G7L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS06715
gene id: 204722:BR_RS06715
uniprot id: Q8FZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Tam family.
messages: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
messages: Cytoplasm

204722:BR RS15440
gene id: 204722:BR_RS15440
uniprot id: A0A0H3GGE0
names: Similarity
messages: Belongs to the virb1 family.

204722:BR RS07310
gene id: 204722:BR_RS07310
uniprot id: A0A0H3G8M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS13460
gene id: 204722:BR_RS13460
uniprot id: A0A0H3GFK9
names: Function
names: Similarity
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

204722:BR RS14195
gene id: 204722:BR_RS14195
uniprot id: A0A0H3G7E2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

204722:BR RS14085
gene id: 204722:BR_RS14085
uniprot id: A0A0H3G7C1
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

204722:BR RS12150
gene id: 204722:BR_RS12150
uniprot id: A0A0H3GEZ0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

204722:BR RS14425
gene id: 204722:BR_RS14425
uniprot id: A0A0H3G7H3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS10305
gene id: 204722:BR_RS10305
uniprot id: A0A0H3GE31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
messages: Homotetramer.

204722:BR RS15405
gene id: 204722:BR_RS15405
uniprot id: A0A0H3G7V0
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

204722:BR RS07155
gene id: 204722:BR_RS07155
uniprot id: P63851
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

204722:BR RS04710
gene id: 204722:BR_RS04710
uniprot id: A0A0H3GBL4
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

204722:BR RS07140
gene id: 204722:BR_RS07140
uniprot id: A0A0H3G8J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

204722:BR RS05060
gene id: 204722:BR_RS05060
uniprot id: A0A0H3G7M9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS12830
gene id: 204722:BR_RS12830
uniprot id: Q8FW67
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

204722:BR RS03715
gene id: 204722:BR_RS03715
uniprot id: Q8G1B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS08170
gene id: 204722:BR_RS08170
uniprot id: P66206
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

204722:BR RS12900
gene id: 204722:BR_RS12900
uniprot id: A0A0H3G6L6
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS12570
gene id: 204722:BR_RS12570
uniprot id: A0A0H3GAL7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

204722:BR RS03730
gene id: 204722:BR_RS03730
uniprot id: A0A0H3G6A7
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

204722:BR RS15230
gene id: 204722:BR_RS15230
uniprot id: A0A0H3GBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS04975
gene id: 204722:BR_RS04975
uniprot id: Q8G0L4
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

204722:BR RS05960
gene id: 204722:BR_RS05960
uniprot id: A0A0H3G800
names: Similarity
messages: Belongs to the CobH/CbiC family.

204722:BR RS09110
gene id: 204722:BR_RS09110
uniprot id: Q8FYA6
names: Similarity
messages: Belongs to the UPF0178 family.

204722:BR RS03460
gene id: 204722:BR_RS03460
uniprot id: A0A0H3G2P3
names: Similarity
messages: Belongs to the GppA/Ppx family.

204722:BR RS11420
gene id: 204722:BR_RS11420
uniprot id: A0A0H3G5Z6
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03190
gene id: 204722:BR_RS03190
uniprot id: A0A0H3G2T0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS09700
gene id: 204722:BR_RS09700
uniprot id: Q8FXY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

204722:BR RS13265
gene id: 204722:BR_RS13265
uniprot id: A0A0H3G7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS04745
gene id: 204722:BR_RS04745
uniprot id: A0A0H3G3M8
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

204722:BR RS08205
gene id: 204722:BR_RS08205
uniprot id: Q8FYS9
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS05260
gene id: 204722:BR_RS05260
uniprot id: Q8G0G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

204722:BR RS07665
gene id: 204722:BR_RS07665
uniprot id: Q8FZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

204722:BR RS08885
gene id: 204722:BR_RS08885
uniprot id: P0A3P2
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhizobiaceae omp19 lipoprotein family.
messages: Cell outer membrane
messages: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle.

204722:BR RS02865
gene id: 204722:BR_RS02865
uniprot id: A0A0H3G2F9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS07430
gene id: 204722:BR_RS07430
uniprot id: A0A0H3G4U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS05660
gene id: 204722:BR_RS05660
uniprot id: Q8G085
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

204722:BR RS01555
gene id: 204722:BR_RS01555
uniprot id: A0A0H3G569
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

204722:BR RS11805
gene id: 204722:BR_RS11805
uniprot id: Q8FWR4
names: Similarity
messages: Belongs to the UPF0423 family.

204722:BR RS02195
gene id: 204722:BR_RS02195
uniprot id: Q8G257
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

204722:BR RS05135
gene id: 204722:BR_RS05135
uniprot id: Q8G0I7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

204722:BR RS10045
gene id: 204722:BR_RS10045
uniprot id: A0A0H3G9T5
names: Similarity
messages: Belongs to the peptidase M17 family.

204722:BR RS03580
gene id: 204722:BR_RS03580
uniprot id: P64391
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

204722:BR RS06285
gene id: 204722:BR_RS06285
uniprot id: Q8FZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS06335
gene id: 204722:BR_RS06335
uniprot id: Q8FZV0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

204722:BR RS02140
gene id: 204722:BR_RS02140
uniprot id: P65218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

204722:BR RS15490
gene id: 204722:BR_RS15490
uniprot id: Q8FUR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (XylG), two transmembrane proteins (XylH) and a solute-binding protein (XylF).

204722:BR RS15040
gene id: 204722:BR_RS15040
uniprot id: Q8FUZ2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

204722:BR RS08200
gene id: 204722:BR_RS08200
uniprot id: A0A0H3G916
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

204722:BR RS13735
gene id: 204722:BR_RS13735
uniprot id: P59225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

204722:BR RS15350
gene id: 204722:BR_RS15350
uniprot id: Q8FUU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).

204722:BR RS12910
gene id: 204722:BR_RS12910
uniprot id: A0A0H3GAS1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS12700
gene id: 204722:BR_RS12700
uniprot id: A0A0H3GAN9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04715
gene id: 204722:BR_RS04715
uniprot id: A0A0H3G332
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

204722:BR RS08730
gene id: 204722:BR_RS08730
uniprot id: A0A0H3GDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

204722:BR RS07910
gene id: 204722:BR_RS07910
uniprot id: Q8FYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

204722:BR RS05045
gene id: 204722:BR_RS05045
uniprot id: A0A0H3GBS0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS09970
gene id: 204722:BR_RS09970
uniprot id: Q8FXT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

204722:BR RS08455
gene id: 204722:BR_RS08455
uniprot id: P67517
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

204722:BR RS10245
gene id: 204722:BR_RS10245
uniprot id: A0A0H3G597
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

204722:BR RS13880
gene id: 204722:BR_RS13880
uniprot id: Q8FVL9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

204722:BR RS15565
gene id: 204722:BR_RS15565
uniprot id: Q8FUQ2
names: Similarity
messages: Belongs to the UPF0261 family.

204722:BR RS03315
gene id: 204722:BR_RS03315
uniprot id: A0A0H3G640
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

204722:BR RS01430
gene id: 204722:BR_RS01430
uniprot id: A0A0H3G9Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

204722:BR RS11550
gene id: 204722:BR_RS11550
uniprot id: A0A0H3G6S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

204722:BR RS09175
gene id: 204722:BR_RS09175
uniprot id: A0A0H3GDK4
names: Similarity
messages: Belongs to the YggT family.

204722:BR RS09040
gene id: 204722:BR_RS09040
uniprot id: A0A0H3G4T1
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS13815
gene id: 204722:BR_RS13815
uniprot id: A0A0H3GFR3
names: Similarity
messages: Belongs to the UxaA family.

204722:BR RS01560
gene id: 204722:BR_RS01560
uniprot id: A0A0H3GA12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS12335
gene id: 204722:BR_RS12335
uniprot id: Q8FWG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

204722:BR RS14915
gene id: 204722:BR_RS14915
uniprot id: Q8FV17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

204722:BR RS09465
gene id: 204722:BR_RS09465
uniprot id: A0A0H3G5T7
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

204722:BR RS06025
gene id: 204722:BR_RS06025
uniprot id: A0A0H3G808
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

204722:BR RS01860
gene id: 204722:BR_RS01860
uniprot id: Q8G2C1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

204722:BR RS11065
gene id: 204722:BR_RS11065
uniprot id: P65490
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

204722:BR RS13070
gene id: 204722:BR_RS13070
uniprot id: A0A0H3GFE9
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

204722:BR RS01705
gene id: 204722:BR_RS01705
uniprot id: A0A0H3G5X5
names: Function
names: Similarity
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: May be required for disulfide bond formation in some proteins.

204722:BR RS13805
gene id: 204722:BR_RS13805
uniprot id: A0A0H3G7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS05630
gene id: 204722:BR_RS05630
uniprot id: Q8G089
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

204722:BR RS05565
gene id: 204722:BR_RS05565
uniprot id: P67009
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

204722:BR RS06300
gene id: 204722:BR_RS06300
uniprot id: A0A0H3G4D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

204722:BR RS04025
gene id: 204722:BR_RS04025
uniprot id: A0A0H3G390
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

204722:BR RS09955
gene id: 204722:BR_RS09955
uniprot id: A0A0H3G551
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

204722:BR RS11490
gene id: 204722:BR_RS11490
uniprot id: A0A0H3G611
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS07090
gene id: 204722:BR_RS07090
uniprot id: P65864
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

204722:BR RS05080
gene id: 204722:BR_RS05080
uniprot id: A0A0H3GBS5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

204722:BR RS03275
gene id: 204722:BR_RS03275
uniprot id: A0A0H3G630
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

204722:BR RS09985
gene id: 204722:BR_RS09985
uniprot id: Q8FXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

204722:BR RS07850
gene id: 204722:BR_RS07850
uniprot id: Q8FZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

204722:BR RS12845
gene id: 204722:BR_RS12845
uniprot id: Q8FW65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

204722:BR RS10445
gene id: 204722:BR_RS10445
uniprot id: A0A0H3GE43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

204722:BR RS08825
gene id: 204722:BR_RS08825
uniprot id: Q7ZAN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

204722:BR RS00715
gene id: 204722:BR_RS00715
uniprot id: Q8G304
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

204722:BR RS02820
gene id: 204722:BR_RS02820
uniprot id: A0A0H3G2L3
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

204722:BR RS04700
gene id: 204722:BR_RS04700
uniprot id: Q8G0S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

204722:BR RS15455
gene id: 204722:BR_RS15455
uniprot id: A0A0H3GC04
names: Similarity
messages: Belongs to the MotB family.

204722:BR RS02625
gene id: 204722:BR_RS02625
uniprot id: A0A0H3G2C3
names: Similarity
messages: Belongs to the ros/MucR family.

204722:BR RS10800
gene id: 204722:BR_RS10800
uniprot id: A0A0H3GA73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

204722:BR RS11405
gene id: 204722:BR_RS11405
uniprot id: A0A0H3GAK9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS07810
gene id: 204722:BR_RS07810
uniprot id: A0A0H3G8U8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05225
gene id: 204722:BR_RS05225
uniprot id: A0A0H3G7Q4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

204722:BR RS09035
gene id: 204722:BR_RS09035
uniprot id: A0A0H3GDI6
names: Similarity
messages: Belongs to the asparaginase 1 family.

204722:BR RS03525
gene id: 204722:BR_RS03525
uniprot id: P67312
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

204722:BR RS10145
gene id: 204722:BR_RS10145
uniprot id: A0A0H3G581
names: Similarity
messages: Belongs to the isochorismate synthase family.

204722:BR RS01695
gene id: 204722:BR_RS01695
uniprot id: A0A0H3GA33
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Cell membrane
messages: Membrane

204722:BR RS01000
gene id: 204722:BR_RS01000
uniprot id: A0A0H3G1M2
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

204722:BR RS11205
gene id: 204722:BR_RS11205
uniprot id: A0A0H3G9W3
names: Subcellular Location Annotation
messages: Cell membrane

204722:BR RS12835
gene id: 204722:BR_RS12835
uniprot id: P64204
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

204722:BR RS03980
gene id: 204722:BR_RS03980
uniprot id: A0A0H3G2W3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS03170
gene id: 204722:BR_RS03170
uniprot id: A0A0H3GAV1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

204722:BR RS13615
gene id: 204722:BR_RS13615
uniprot id: A0A0H3G712
names: Function
names: Similarity
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

204722:BR RS05995
gene id: 204722:BR_RS05995
uniprot id: Q8G022
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

204722:BR RS02055
gene id: 204722:BR_RS02055
uniprot id: A0A0H3G5F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

204722:BR RS02300
gene id: 204722:BR_RS02300
uniprot id: A0A0H3G285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
messages: Membrane

204722:BR RS11255
gene id: 204722:BR_RS11255
uniprot id: A0A0H3G9Z9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Binds 1 Cu(+) ion.
messages: Homotrimer.
messages: Periplasm

204722:BR RS14110
gene id: 204722:BR_RS14110
uniprot id: A0A0H3GFW9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

204722:BR RS04135
gene id: 204722:BR_RS04135
uniprot id: P64233
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

204722:BR RS13245
gene id: 204722:BR_RS13245
uniprot id: Q8FVY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

204722:BR RS04170
gene id: 204722:BR_RS04170
uniprot id: P64198
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

204722:BR RS12545
gene id: 204722:BR_RS12545
uniprot id: A0A0H3GF63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS11685
gene id: 204722:BR_RS11685
uniprot id: A0A0H3GAR0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS07290
gene id: 204722:BR_RS07290
uniprot id: A0A0H3G4S0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS02355
gene id: 204722:BR_RS02355
uniprot id: A0A0H3G693
names: Similarity
messages: Belongs to the polysaccharide synthase family.

204722:BR RS14525
gene id: 204722:BR_RS14525
uniprot id: A0A0H3G843
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04760
gene id: 204722:BR_RS04760
uniprot id: A0A0H3G338
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

204722:BR RS01100
gene id: 204722:BR_RS01100
uniprot id: A0A0H3G509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS15420
gene id: 204722:BR_RS15420
uniprot id: A0A0H3GCE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

204722:BR RS03220
gene id: 204722:BR_RS03220
uniprot id: A0A0H3G6Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

204722:BR RS04115
gene id: 204722:BR_RS04115
uniprot id: P0A4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

204722:BR RS07050
gene id: 204722:BR_RS07050
uniprot id: A0A0H3G7Z8
names: Subcellular Location Annotation
messages: Mitochondrion

204722:BR RS01030
gene id: 204722:BR_RS01030
uniprot id: A0A0H3G4Z6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS03745
gene id: 204722:BR_RS03745
uniprot id: Q8G1A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS04315
gene id: 204722:BR_RS04315
uniprot id: A0A0H3GBE5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.

204722:BR RS05145
gene id: 204722:BR_RS05145
uniprot id: Q8G0I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

204722:BR RS06905
gene id: 204722:BR_RS06905
uniprot id: A0A0H3G3U5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS06865
gene id: 204722:BR_RS06865
uniprot id: A0A0H3G7W6
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS00375
gene id: 204722:BR_RS00375
uniprot id: A0A0H3G1A9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS07875
gene id: 204722:BR_RS07875
uniprot id: Q8FZ02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

204722:BR RS08605
gene id: 204722:BR_RS08605
uniprot id: Q8FYK3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

204722:BR RS11830
gene id: 204722:BR_RS11830
uniprot id: A0A0H3GAS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

204722:BR RS04585
gene id: 204722:BR_RS04585
uniprot id: A0A0H3G7D7
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

204722:BR RS00360
gene id: 204722:BR_RS00360
uniprot id: Q8G374
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

204722:BR RS00235
gene id: 204722:BR_RS00235
uniprot id: A0A0H3G4L6
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS14435
gene id: 204722:BR_RS14435
uniprot id: A0A0H3GC11
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

204722:BR RS14190
gene id: 204722:BR_RS14190
uniprot id: A0A0H3GFX8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS02480
gene id: 204722:BR_RS02480
uniprot id: A0A0H3GAI0
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

204722:BR RS00050
gene id: 204722:BR_RS00050
uniprot id: A0A0H3G9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS09315
gene id: 204722:BR_RS09315
uniprot id: A0A0H3G4X8
names: Similarity
messages: Belongs to the BolA/IbaG family.

204722:BR RS13975
gene id: 204722:BR_RS13975
uniprot id: A0A0H3GBA7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

204722:BR RS15185
gene id: 204722:BR_RS15185
uniprot id: A0A0H3G7S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS00400
gene id: 204722:BR_RS00400
uniprot id: A0A0H3G595
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS13515
gene id: 204722:BR_RS13515
uniprot id: Q8FVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (Probable).
messages: The complex is composed of two ATP-binding proteins (BRA0745), two transmembrane proteins (BRA0749) and a solute-binding protein (BRA0748).

204722:BR RS10890
gene id: 204722:BR_RS10890
uniprot id: A0A0H3GA88
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

204722:BR RS07625
gene id: 204722:BR_RS07625
uniprot id: Q8FZ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Monomer.

204722:BR RS10490
gene id: 204722:BR_RS10490
uniprot id: Q8FXI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).

204722:BR RS11890
gene id: 204722:BR_RS11890
uniprot id: A0A0H3GAT7
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

204722:BR RS11290
gene id: 204722:BR_RS11290
uniprot id: A0A0H3GEL2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

204722:BR RS15690
gene id: 204722:BR_RS15690
uniprot id: A0A0H3GCI5
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10510
gene id: 204722:BR_RS10510
uniprot id: A0A0H3GE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

204722:BR RS03895
gene id: 204722:BR_RS03895
uniprot id: A0A0H3G366
names: Similarity
messages: Belongs to the HpcH/HpaI aldolase family.

204722:BR RS05295
gene id: 204722:BR_RS05295
uniprot id: P66989
names: Similarity
messages: Belongs to the TrpC family.

204722:BR RS13065
gene id: 204722:BR_RS13065
uniprot id: A0A0H3G7E0
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

204722:BR RS03530
gene id: 204722:BR_RS03530
uniprot id: A0A0H3GB22
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

204722:BR RS14770
gene id: 204722:BR_RS14770
uniprot id: A0A0H3G884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS07990
gene id: 204722:BR_RS07990
uniprot id: A0A0H3G8F4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

204722:BR RS06545
gene id: 204722:BR_RS06545
uniprot id: Q8FZQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

204722:BR RS06280
gene id: 204722:BR_RS06280
uniprot id: A0A0H3G842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

204722:BR RS04895
gene id: 204722:BR_RS04895
uniprot id: A0A0H3G355
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

204722:BR RS06610
gene id: 204722:BR_RS06610
uniprot id: Q8CY39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

204722:BR RS04305
gene id: 204722:BR_RS04305
uniprot id: A0A0H3G792
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

204722:BR RS04035
gene id: 204722:BR_RS04035
uniprot id: A0A0H3G2W9
names: Similarity
messages: Belongs to the HesB/IscA family.

204722:BR RS01015
gene id: 204722:BR_RS01015
uniprot id: A0A0H3G1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

204722:BR RS13755
gene id: 204722:BR_RS13755
uniprot id: A0A0H3GB72
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

204722:BR RS09365
gene id: 204722:BR_RS09365
uniprot id: A0A0H3G918
names: Similarity
messages: Belongs to the peptidase S11 family.

204722:BR RS02825
gene id: 204722:BR_RS02825
uniprot id: P0A3Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
messages: Periplasm

204722:BR RS10205
gene id: 204722:BR_RS10205
uniprot id: A0A0H3G9D3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS09600
gene id: 204722:BR_RS09600
uniprot id: Q8FY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

204722:BR RS02020
gene id: 204722:BR_RS02020
uniprot id: A0A0H3G5F2
names: Similarity
messages: Belongs to the TlyA family.

204722:BR RS14990
gene id: 204722:BR_RS14990
uniprot id: A0A0H3GG93
names: Similarity
messages: Belongs to the universal stress protein A family.

204722:BR RS08235
gene id: 204722:BR_RS08235
uniprot id: A0A0H3GD58
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS11930
gene id: 204722:BR_RS11930
uniprot id: A0A0H3GAU2
names: Similarity
messages: Belongs to the DapA family.

204722:BR RS12245
gene id: 204722:BR_RS12245
uniprot id: A0A0H3GAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS10830
gene id: 204722:BR_RS10830
uniprot id: A0A0H3G6D6
names: Similarity
messages: Belongs to the HpcH/HpaI aldolase family.

204722:BR RS02405
gene id: 204722:BR_RS02405
uniprot id: A0A0H3G296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS08590
gene id: 204722:BR_RS08590
uniprot id: Q7CEG6
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: By heat and acid shock.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

204722:BR RS01245
gene id: 204722:BR_RS01245
uniprot id: Q8G2Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS03265
gene id: 204722:BR_RS03265
uniprot id: A0A0H3GAW5
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

204722:BR RS10625
gene id: 204722:BR_RS10625
uniprot id: A0A0H3GA36
names: Similarity
messages: Belongs to the type III secretion exporter family.

204722:BR RS01410
gene id: 204722:BR_RS01410
uniprot id: P63567
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

204722:BR RS00315
gene id: 204722:BR_RS00315
uniprot id: A0A0H3G9F9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08940
gene id: 204722:BR_RS08940
uniprot id: A0A0H3G9C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

204722:BR RS12140
gene id: 204722:BR_RS12140
uniprot id: P65448
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.

204722:BR RS04400
gene id: 204722:BR_RS04400
uniprot id: A0A0H3G3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS05265
gene id: 204722:BR_RS05265
uniprot id: Q8G0G1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

204722:BR RS11175
gene id: 204722:BR_RS11175
uniprot id: A0A0H3G5R4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS01640
gene id: 204722:BR_RS01640
uniprot id: A0A0H3G1X8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS01185
gene id: 204722:BR_RS01185
uniprot id: Q8G2R2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

204722:BR RS06845
gene id: 204722:BR_RS06845
uniprot id: A0A0H3G8D6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

204722:BR RS07045
gene id: 204722:BR_RS07045
uniprot id: Q8FZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

204722:BR RS13485
gene id: 204722:BR_RS13485
uniprot id: A0A0H3G6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS02160
gene id: 204722:BR_RS02160
uniprot id: A0A0H3G233
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

204722:BR RS08290
gene id: 204722:BR_RS08290
uniprot id: A0A0H3G4H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

204722:BR RS08705
gene id: 204722:BR_RS08705
uniprot id: A0A0H3G8S4
names: Subcellular Location Annotation
messages: Nucleus

204722:BR RS06290
gene id: 204722:BR_RS06290
uniprot id: Q8FZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS03770
gene id: 204722:BR_RS03770
uniprot id: A0A0H3G6B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS10195
gene id: 204722:BR_RS10195
uniprot id: A0A0H3GE10
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS06240
gene id: 204722:BR_RS06240
uniprot id: A0A0H3G4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

204722:BR RS05230
gene id: 204722:BR_RS05230
uniprot id: A0A0H3G3X3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

204722:BR RS12590
gene id: 204722:BR_RS12590
uniprot id: A0A0H3G6H9
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

204722:BR RS05070
gene id: 204722:BR_RS05070
uniprot id: Q8G0K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

204722:BR RS06270
gene id: 204722:BR_RS06270
uniprot id: Q8FZW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS12210
gene id: 204722:BR_RS12210
uniprot id: A0A0H3G6B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

204722:BR RS03165
gene id: 204722:BR_RS03165
uniprot id: A0A0H3G2S5
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS13340
gene id: 204722:BR_RS13340
uniprot id: A0A0H3GFJ0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS02240
gene id: 204722:BR_RS02240
uniprot id: A0A0H3G243
names: Similarity
messages: Belongs to the threonine synthase family.

204722:BR RS06325
gene id: 204722:BR_RS06325
uniprot id: Q8FZV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

204722:BR RS12250
gene id: 204722:BR_RS12250
uniprot id: A0A0H3GAZ2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS03455
gene id: 204722:BR_RS03455
uniprot id: A0A0H3GB06
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

204722:BR RS03630
gene id: 204722:BR_RS03630
uniprot id: P59314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

204722:BR RS10385
gene id: 204722:BR_RS10385
uniprot id: Q9RPY4
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the virb1 family.
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS11560
gene id: 204722:BR_RS11560
uniprot id: A0A0H3G624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS08685
gene id: 204722:BR_RS08685
uniprot id: Q8FYI6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

204722:BR RS06540
gene id: 204722:BR_RS06540
uniprot id: A0A0H3G3P5
names: Similarity
messages: Belongs to the SCO1/2 family.

204722:BR RS13470
gene id: 204722:BR_RS13470
uniprot id: Q8FVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport (By similarity).

204722:BR RS11385
gene id: 204722:BR_RS11385
uniprot id: A0A0H3G6Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

204722:BR RS00660
gene id: 204722:BR_RS00660
uniprot id: P67587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

204722:BR RS00925
gene id: 204722:BR_RS00925
uniprot id: A0A0H3G5J6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

204722:BR RS10615
gene id: 204722:BR_RS10615
uniprot id: Q8FXF9
names: Function
messages: Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes.

204722:BR RS15670
gene id: 204722:BR_RS15670
uniprot id: A0A0H3GGH4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

204722:BR RS03430
gene id: 204722:BR_RS03430
uniprot id: A0A0H3GB02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS15530
gene id: 204722:BR_RS15530
uniprot id: A0A0H3G7W4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS15470
gene id: 204722:BR_RS15470
uniprot id: A0A0H3G8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

204722:BR RS15590
gene id: 204722:BR_RS15590
uniprot id: A0A0H3GC30
names: Function
messages: Component of an amino-acid transport system.

204722:BR RS14305
gene id: 204722:BR_RS14305
uniprot id: A0A0H3GBJ6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

204722:BR RS07865
gene id: 204722:BR_RS07865
uniprot id: A0A0H3G487
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

204722:BR RS00460
gene id: 204722:BR_RS00460
uniprot id: Q8G353
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

204722:BR RS05215
gene id: 204722:BR_RS05215
uniprot id: P65282
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

204722:BR RS08925
gene id: 204722:BR_RS08925
uniprot id: A0A0H3GDG8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

204722:BR RS10115
gene id: 204722:BR_RS10115
uniprot id: A0A0H3GDZ5
names: Similarity
messages: Belongs to the BMP lipoprotein family.

204722:BR RS07885
gene id: 204722:BR_RS07885
uniprot id: Q8FZ01
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

204722:BR RS03880
gene id: 204722:BR_RS03880
uniprot id: A0A0H3G6D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

204722:BR RS12480
gene id: 204722:BR_RS12480
uniprot id: A0A0H3G6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS08310
gene id: 204722:BR_RS08310
uniprot id: A0A0H3G948
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

204722:BR RS06265
gene id: 204722:BR_RS06265
uniprot id: Q8FZW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS13230
gene id: 204722:BR_RS13230
uniprot id: A0A0H3GBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS09455
gene id: 204722:BR_RS09455
uniprot id: A0A0H3G935
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS10600
gene id: 204722:BR_RS10600
uniprot id: A0A0H3GE76
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14040
gene id: 204722:BR_RS14040
uniprot id: A0A0H3GFU9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08475
gene id: 204722:BR_RS08475
uniprot id: P65791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

204722:BR RS02475
gene id: 204722:BR_RS02475
uniprot id: A0A0H3G2E6
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

204722:BR RS08890
gene id: 204722:BR_RS08890
uniprot id: Q8FYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS11325
gene id: 204722:BR_RS11325
uniprot id: Q8FX16
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Binds 2 calcium ions per subunit.
messages: Binds 6 Cu cations per subunit. Each subunit contains 2 copper centers; Cu(A) (binuclear) and Cu(Z) (tetranuclear). Cu(Z) is thought to be the site of nitrous oxide reduction.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

204722:BR RS08735
gene id: 204722:BR_RS08735
uniprot id: A0A0H3G8S8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

204722:BR RS11455
gene id: 204722:BR_RS11455
uniprot id: A0A0H3G6R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

204722:BR RS14685
gene id: 204722:BR_RS14685
uniprot id: A0A0H3G869
names: Similarity
messages: Belongs to the RutC family.

204722:BR RS13405
gene id: 204722:BR_RS13405
uniprot id: A0A0H3G7J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS11165
gene id: 204722:BR_RS11165
uniprot id: A0A0H3G9V2
names: Similarity
messages: Belongs to the DapA family.

204722:BR RS10410
gene id: 204722:BR_RS10410
uniprot id: A0A0H3GE41
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS15150
gene id: 204722:BR_RS15150
uniprot id: Q8FUX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm
messages: Probably part of an ABC transporter complex that could be involved in peptide import.
messages: The complex is composed of two ATP-binding proteins (BRA1094), two transmembrane proteins (BRA1092 and BRA1093) and a solute-binding protein (BRA1090).

204722:BR RS10380
gene id: 204722:BR_RS10380
uniprot id: Q7CEG0
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PtlA family.
messages: Cell membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS00310
gene id: 204722:BR_RS00310
uniprot id: A0A0H3G1A2
names: Similarity
messages: Belongs to the virb1 family.

204722:BR RS03760
gene id: 204722:BR_RS03760
uniprot id: A0A0H3GB54
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

204722:BR RS13030
gene id: 204722:BR_RS13030
uniprot id: A0A0H3GAU1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

204722:BR RS01760
gene id: 204722:BR_RS01760
uniprot id: A0A0H3G1X5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

204722:BR RS04420
gene id: 204722:BR_RS04420
uniprot id: Q8G0X5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

204722:BR RS01720
gene id: 204722:BR_RS01720
uniprot id: A0A0H3G1X1
names: Similarity
messages: Belongs to the ArsC family.

204722:BR RS00740
gene id: 204722:BR_RS00740
uniprot id: A0A0H3G5F6
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

204722:BR RS06090
gene id: 204722:BR_RS06090
uniprot id: A0A0H3GC79
names: Similarity
messages: Belongs to the HIBADH-related family.

204722:BR RS04690
gene id: 204722:BR_RS04690
uniprot id: A0A0H3G7F8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

204722:BR RS09820
gene id: 204722:BR_RS09820
uniprot id: Q8FXW6
names: Cofactor
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

204722:BR RS08325
gene id: 204722:BR_RS08325
uniprot id: Q8FYQ3
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

204722:BR RS10005
gene id: 204722:BR_RS10005
uniprot id: P64104
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

204722:BR RS15465
gene id: 204722:BR_RS15465
uniprot id: Q8FUS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.
messages: Cell inner membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity).

204722:BR RS05435
gene id: 204722:BR_RS05435
uniprot id: A0A0H3G424
names: Similarity
messages: Belongs to the peptidase S11 family.

204722:BR RS07390
gene id: 204722:BR_RS07390
uniprot id: A0A0H3G416
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

204722:BR RS03120
gene id: 204722:BR_RS03120
uniprot id: Q8G1N5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

204722:BR RS14285
gene id: 204722:BR_RS14285
uniprot id: A0A0H3G809
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

204722:BR RS07415
gene id: 204722:BR_RS07415
uniprot id: Q8FZ86
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn regulates CtrA, a transcriptional regulator of the minB operon. The asymmetrical localization of this protein is probably required for cells to enter a new division cycle (By similarity).
messages: Interacts with DivK.

204722:BR RS03010
gene id: 204722:BR_RS03010
uniprot id: P65911
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

204722:BR RS15505
gene id: 204722:BR_RS15505
uniprot id: A0A0H3G7W1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS10990
gene id: 204722:BR_RS10990
uniprot id: A0A0H3GAA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

204722:BR RS08295
gene id: 204722:BR_RS08295
uniprot id: Q8FYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

204722:BR RS05425
gene id: 204722:BR_RS05425
uniprot id: A0A0H3G798
names: Similarity
messages: Belongs to the ClpA/ClpB family.

204722:BR RS10355
gene id: 204722:BR_RS10355
uniprot id: Q7CEG2
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS13970
gene id: 204722:BR_RS13970
uniprot id: A0A0H3G770
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

204722:BR RS15640
gene id: 204722:BR_RS15640
uniprot id: A0A0H3GC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS05620
gene id: 204722:BR_RS05620
uniprot id: A0A0H3GC31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

204722:BR RS00215
gene id: 204722:BR_RS00215
uniprot id: A0A0H3G4L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

204722:BR RS13125
gene id: 204722:BR_RS13125
uniprot id: Q8FW08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

204722:BR RS05585
gene id: 204722:BR_RS05585
uniprot id: A0A0H3G7W8
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

204722:BR RS10765
gene id: 204722:BR_RS10765
uniprot id: P67707
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.

204722:BR RS04625
gene id: 204722:BR_RS04625
uniprot id: A0A0H3GBJ8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

204722:BR RS14865
gene id: 204722:BR_RS14865
uniprot id: Q8FV25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

204722:BR RS00510
gene id: 204722:BR_RS00510
uniprot id: P63354
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

204722:BR RS02145
gene id: 204722:BR_RS02145
uniprot id: A0A0H3G653
names: Similarity
messages: Belongs to the peptidase U62 family.

204722:BR RS04725
gene id: 204722:BR_RS04725
uniprot id: A0A0H3G7G3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS15100
gene id: 204722:BR_RS15100
uniprot id: A0A0H3G7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS12345
gene id: 204722:BR_RS12345
uniprot id: A0A0H3GF23
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. BioZ family.
messages: Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.

204722:BR RS12930
gene id: 204722:BR_RS12930
uniprot id: Q8FW50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

204722:BR RS05290
gene id: 204722:BR_RS05290
uniprot id: Q8G0F5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

204722:BR RS03485
gene id: 204722:BR_RS03485
uniprot id: P63647
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

204722:BR RS06840
gene id: 204722:BR_RS06840
uniprot id: A0A0H3G7W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

204722:BR RS07265
gene id: 204722:BR_RS07265
uniprot id: A0A0H3G3Z7
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS11375
gene id: 204722:BR_RS11375
uniprot id: A0A0H3GEM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS05155
gene id: 204722:BR_RS05155
uniprot id: P0A3G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

204722:BR RS02085
gene id: 204722:BR_RS02085
uniprot id: A0A0H3G247
names: Similarity
messages: Belongs to the CFA/CMAS family.

204722:BR RS11670
gene id: 204722:BR_RS11670
uniprot id: Q8FWU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Homotetramer.
messages: Periplasm

204722:BR RS03750
gene id: 204722:BR_RS03750
uniprot id: A0A0H3G337
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS06425
gene id: 204722:BR_RS06425
uniprot id: A0A0H3G862
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

204722:BR RS04945
gene id: 204722:BR_RS04945
uniprot id: A0A0H3G6Z9
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

204722:BR RS04410
gene id: 204722:BR_RS04410
uniprot id: A0A0H3G6N1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

204722:BR RS12440
gene id: 204722:BR_RS12440
uniprot id: A0A0H3G6F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

204722:BR RS03710
gene id: 204722:BR_RS03710
uniprot id: Q8G1B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

204722:BR RS11500
gene id: 204722:BR_RS11500
uniprot id: P65547
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

204722:BR RS04080
gene id: 204722:BR_RS04080
uniprot id: A0A0H3G6H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

204722:BR RS06595
gene id: 204722:BR_RS06595
uniprot id: Q8FZP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

204722:BR RS00185
gene id: 204722:BR_RS00185
uniprot id: Q8G3B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

204722:BR RS03215
gene id: 204722:BR_RS03215
uniprot id: A0A0H3G621
names: Similarity
messages: Belongs to the MoaD family.

204722:BR RS14830
gene id: 204722:BR_RS14830
uniprot id: P66243
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

204722:BR RS10100
gene id: 204722:BR_RS10100
uniprot id: A0A0H3G9B3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04360
gene id: 204722:BR_RS04360
uniprot id: A0A0H3G3F1
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

204722:BR RS03795
gene id: 204722:BR_RS03795
uniprot id: Q8G197
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Cytoplasm
messages: Homodimer.

204722:BR RS05390
gene id: 204722:BR_RS05390
uniprot id: Q8G0D6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

204722:BR RS01275
gene id: 204722:BR_RS01275
uniprot id: Q8G2P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS00975
gene id: 204722:BR_RS00975
uniprot id: A0A0H3G4Y6
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

204722:BR RS01535
gene id: 204722:BR_RS01535
uniprot id: A0A0H3G1V7
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS00525
gene id: 204722:BR_RS00525
uniprot id: A0A0H3G1F1
names: Similarity
messages: Belongs to the PhzF family.

204722:BR RS06065
gene id: 204722:BR_RS06065
uniprot id: A0A0H3G3I7
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

204722:BR RS07800
gene id: 204722:BR_RS07800
uniprot id: A0A0H3GCZ2
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

204722:BR RS08260
gene id: 204722:BR_RS08260
uniprot id: P63661
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

204722:BR RS12355
gene id: 204722:BR_RS12355
uniprot id: Q8FWG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS02180
gene id: 204722:BR_RS02180
uniprot id: A0A0H3G661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

204722:BR RS12880
gene id: 204722:BR_RS12880
uniprot id: A0A0H3GAR6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

204722:BR RS03025
gene id: 204722:BR_RS03025
uniprot id: A0A0H3G2I0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03835
gene id: 204722:BR_RS03835
uniprot id: Q8G189
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

204722:BR RS12820
gene id: 204722:BR_RS12820
uniprot id: A0A0H3GFA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

204722:BR RS06135
gene id: 204722:BR_RS06135
uniprot id: A0A0H3G7J5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

204722:BR RS13435
gene id: 204722:BR_RS13435
uniprot id: A0A0H3GFK4
names: Similarity
messages: Belongs to the GcvT family.

204722:BR RS00170
gene id: 204722:BR_RS00170
uniprot id: A0A0H3G553
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS01975
gene id: 204722:BR_RS01975
uniprot id: P63608
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

204722:BR RS02410
gene id: 204722:BR_RS02410
uniprot id: A0A0H3G5P2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

204722:BR RS08145
gene id: 204722:BR_RS08145
uniprot id: A0A0H3G552
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

204722:BR RS05560
gene id: 204722:BR_RS05560
uniprot id: A0A0H3G446
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

204722:BR RS03495
gene id: 204722:BR_RS03495
uniprot id: A0A0H3G674
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

204722:BR RS02235
gene id: 204722:BR_RS02235
uniprot id: A0A0H3GAB4
names: Similarity
messages: Belongs to the peptidase M16 family.

204722:BR RS14375
gene id: 204722:BR_RS14375
uniprot id: A0A0H3G822
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS04300
gene id: 204722:BR_RS04300
uniprot id: A0A0H3G6L0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

204722:BR RS00435
gene id: 204722:BR_RS00435
uniprot id: Q8G358
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).

204722:BR RS12465
gene id: 204722:BR_RS12465
uniprot id: A0A0H3GB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS07445
gene id: 204722:BR_RS07445
uniprot id: A0A0H3G857
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

204722:BR RS03785
gene id: 204722:BR_RS03785
uniprot id: A0A0H3GB60
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

204722:BR RS15510
gene id: 204722:BR_RS15510
uniprot id: A0A0H3GC14
names: Similarity
messages: Belongs to the HpcH/HpaI aldolase family.

204722:BR RS02815
gene id: 204722:BR_RS02815
uniprot id: A0A0H3G6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS05330
gene id: 204722:BR_RS05330
uniprot id: A0A0H3G790
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

204722:BR RS04240
gene id: 204722:BR_RS04240
uniprot id: A0A0H3G2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

204722:BR RS01280
gene id: 204722:BR_RS01280
uniprot id: Q8G2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS02270
gene id: 204722:BR_RS02270
uniprot id: Q8G242
names: Function
names: Similarity
messages: A beta subtype methylase that recognizes the double-stranded sequence 5'-GANTC-3' and methylates A-2 on both strands (PubMed:12654995) (By similarity). CcrM-mediated methylation has important cellular functions. Contributes to the accurate cell-cycle control of DNA replication and cellular morphology (By similarity).
messages: Belongs to the N(4)/N(6)-methyltransferase family.

204722:BR RS14245
gene id: 204722:BR_RS14245
uniprot id: P0A2Y0
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

204722:BR RS12695
gene id: 204722:BR_RS12695
uniprot id: A0A0H3G6J0
names: Similarity
messages: Belongs to the BMP lipoprotein family.

204722:BR RS14550
gene id: 204722:BR_RS14550
uniprot id: A0A0H3G847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS15010
gene id: 204722:BR_RS15010
uniprot id: A0A0H3GG97
names: Function
names: Subcellular Location Annotation
messages: Could be a virulence factor.
messages: Membrane
messages: Secreted

204722:BR RS12275
gene id: 204722:BR_RS12275
uniprot id: A0A0H3G6C1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS14415
gene id: 204722:BR_RS14415
uniprot id: A0A0H3G826
names: Function
messages: Acts on leucine, isoleucine and valine.

204722:BR RS12865
gene id: 204722:BR_RS12865
uniprot id: P59246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

204722:BR RS15630
gene id: 204722:BR_RS15630
uniprot id: A0A0H3GGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS12885
gene id: 204722:BR_RS12885
uniprot id: A0A0H3GB93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

204722:BR RS00870
gene id: 204722:BR_RS00870
uniprot id: A0A0H3G4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport.
messages: Membrane

204722:BR RS09330
gene id: 204722:BR_RS09330
uniprot id: Q8FY59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

204722:BR RS13505
gene id: 204722:BR_RS13505
uniprot id: A0A0H3GFL9
names: Similarity
messages: Belongs to the DSD1 family.

204722:BR RS11925
gene id: 204722:BR_RS11925
uniprot id: Q8FWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA0404 and BRA0405), two transmembrane proteins (BRA0407 and BRA0408) and a solute-binding protein (BRA0409).

204722:BR RS12155
gene id: 204722:BR_RS12155
uniprot id: A0A0H3G6B0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

204722:BR RS00335
gene id: 204722:BR_RS00335
uniprot id: A0A0H3G586
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Binds to hyaluronic acid and epithelial cells, and is required for full virulence in the mouse model.
messages: Cell outer membrane
messages: Cell surface
messages: Deletion mutant exhibits a reduction in the adhesion to HeLa and A549 epithelial cells compared with the wild-type strain. Shows an attenuated phenotype in the mouse model.
messages: Homotrimer.
messages: The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface.

204722:BR RS12840
gene id: 204722:BR_RS12840
uniprot id: Q8FW66
names: Similarity
messages: Belongs to the UPF0173 family.

204722:BR RS01680
gene id: 204722:BR_RS01680
uniprot id: A0A0H3G593
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP.
messages: Membrane

204722:BR RS11655
gene id: 204722:BR_RS11655
uniprot id: A0A0H3GAQ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

204722:BR RS02930
gene id: 204722:BR_RS02930
uniprot id: A0A0H3G2H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

204722:BR RS06575
gene id: 204722:BR_RS06575
uniprot id: Q8FZP9
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

204722:BR RS04655
gene id: 204722:BR_RS04655
uniprot id: A0A0H3G327
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS11665
gene id: 204722:BR_RS11665
uniprot id: A0A0H3GES8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS03930
gene id: 204722:BR_RS03930
uniprot id: A0A0H3G735
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

204722:BR RS03255
gene id: 204722:BR_RS03255
uniprot id: A0A0H3G6Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

204722:BR RS12100
gene id: 204722:BR_RS12100
uniprot id: A0A0H3G6A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

204722:BR RS14350
gene id: 204722:BR_RS14350
uniprot id: Q8FVC3
names: Similarity
messages: Belongs to the surface antigen msp4 family.

204722:BR RS15425
gene id: 204722:BR_RS15425
uniprot id: A0A0H3G8H6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

204722:BR RS02100
gene id: 204722:BR_RS02100
uniprot id: P66454
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

204722:BR RS08400
gene id: 204722:BR_RS08400
uniprot id: A0A0H3GDA4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

204722:BR RS10345
gene id: 204722:BR_RS10345
uniprot id: Q9RPX6
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the TrbG/VirB9 family.
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS13800
gene id: 204722:BR_RS13800
uniprot id: A0A0H3GBN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS02570
gene id: 204722:BR_RS02570
uniprot id: A0A0H3G2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

204722:BR RS05365
gene id: 204722:BR_RS05365
uniprot id: Q8G0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Cell inner membrane

204722:BR RS07915
gene id: 204722:BR_RS07915
uniprot id: A0A0H3G8V9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

204722:BR RS07715
gene id: 204722:BR_RS07715
uniprot id: A0A0H3GCX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

204722:BR RS02595
gene id: 204722:BR_RS02595
uniprot id: A0A0H3G2C1
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS04280
gene id: 204722:BR_RS04280
uniprot id: Q8G104
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

204722:BR RS14530
gene id: 204722:BR_RS14530
uniprot id: A0A0H3GG27
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10330
gene id: 204722:BR_RS10330
uniprot id: Q9RPX3
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS05375
gene id: 204722:BR_RS05375
uniprot id: Q8G0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

204722:BR RS01530
gene id: 204722:BR_RS01530
uniprot id: A0A0H3G5U4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS01310
gene id: 204722:BR_RS01310
uniprot id: A0A0H3G1Q8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

204722:BR RS15205
gene id: 204722:BR_RS15205
uniprot id: A0A0H3G8E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS00450
gene id: 204722:BR_RS00450
uniprot id: A0A0H3G5A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

204722:BR RS00875
gene id: 204722:BR_RS00875
uniprot id: A0A0H3G5I3
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

204722:BR RS11725
gene id: 204722:BR_RS11725
uniprot id: A0A0H3GET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbL/VirB6 family.
messages: Membrane

204722:BR RS02900
gene id: 204722:BR_RS02900
uniprot id: A0A0H3G6K1
names: Similarity
messages: Belongs to the GST superfamily.

204722:BR RS14185
gene id: 204722:BR_RS14185
uniprot id: A0A0H3G7Z7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS03210
gene id: 204722:BR_RS03210
uniprot id: P65397
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).

204722:BR RS02205
gene id: 204722:BR_RS02205
uniprot id: P66674
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

204722:BR RS09070
gene id: 204722:BR_RS09070
uniprot id: A0A0H3G9D9
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

204722:BR RS01575
gene id: 204722:BR_RS01575
uniprot id: Q8G2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell inner membrane
messages: Multidrug efflux pump.

204722:BR RS14135
gene id: 204722:BR_RS14135
uniprot id: A0A0H3G7Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

204722:BR RS14105
gene id: 204722:BR_RS14105
uniprot id: Q8FVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS12350
gene id: 204722:BR_RS12350
uniprot id: A0A0H3G6D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS01870
gene id: 204722:BR_RS01870
uniprot id: A0A0H3G5C7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

204722:BR RS06380
gene id: 204722:BR_RS06380
uniprot id: Q8FZU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

204722:BR RS13210
gene id: 204722:BR_RS13210
uniprot id: A0A0H3GBE8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS15360
gene id: 204722:BR_RS15360
uniprot id: A0A0H3GBY7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

204722:BR RS05720
gene id: 204722:BR_RS05720
uniprot id: Q8G076
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

204722:BR RS05315
gene id: 204722:BR_RS05315
uniprot id: A0A0H3G411
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08525
gene id: 204722:BR_RS08525
uniprot id: A0A0H3G4K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

204722:BR RS06450
gene id: 204722:BR_RS06450
uniprot id: A0A0H3G4F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

204722:BR RS03130
gene id: 204722:BR_RS03130
uniprot id: A0A0H3G2S0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

204722:BR RS04765
gene id: 204722:BR_RS04765
uniprot id: A0A0H3G6W0
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

204722:BR RS14895
gene id: 204722:BR_RS14895
uniprot id: P63914
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

204722:BR RS15715
gene id: 204722:BR_RS15715
uniprot id: A0A0H3GC52
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

204722:BR RS02545
gene id: 204722:BR_RS02545
uniprot id: Q8G1Z7
names: Function
messages: Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).

204722:BR RS11905
gene id: 204722:BR_RS11905
uniprot id: A0A0H3GEV8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

204722:BR RS07450
gene id: 204722:BR_RS07450
uniprot id: A0A0H3G8P2
names: Cofactor
messages: Can also use Mn(2+) ion.

204722:BR RS14445
gene id: 204722:BR_RS14445
uniprot id: A0A0H3GG12
names: Similarity
messages: Belongs to the IlvD/Edd family.

204722:BR RS02980
gene id: 204722:BR_RS02980
uniprot id: Q8G1R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

204722:BR RS04605
gene id: 204722:BR_RS04605
uniprot id: P59078
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

204722:BR RS07425
gene id: 204722:BR_RS07425
uniprot id: A0A0H3G8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS04900
gene id: 204722:BR_RS04900
uniprot id: A0A0H3G6Y9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08780
gene id: 204722:BR_RS08780
uniprot id: P66079
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

204722:BR RS08480
gene id: 204722:BR_RS08480
uniprot id: Q8FYM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

204722:BR RS08950
gene id: 204722:BR_RS08950
uniprot id: Q8FYD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

204722:BR RS01370
gene id: 204722:BR_RS01370
uniprot id: Q8G2M7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics.
messages: Periplasm
messages: Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepE.
messages: Repressed by BepR.

204722:BR RS06925
gene id: 204722:BR_RS06925
uniprot id: A0A0H3G3U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

204722:BR RS00140
gene id: 204722:BR_RS00140
uniprot id: A0A0H3G169
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS15595
gene id: 204722:BR_RS15595
uniprot id: A0A0H3GCH1
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05545
gene id: 204722:BR_RS05545
uniprot id: A0A0H3G3E3
names: Similarity
messages: Belongs to the peptidase C56 family.

204722:BR RS10485
gene id: 204722:BR_RS10485
uniprot id: A0A0H3GE48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

204722:BR RS00570
gene id: 204722:BR_RS00570
uniprot id: A0A0H3G1F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

204722:BR RS05320
gene id: 204722:BR_RS05320
uniprot id: Q8G0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

204722:BR RS08090
gene id: 204722:BR_RS08090
uniprot id: Q8FYV6
names: Similarity
messages: Belongs to the UPF0335 family.

204722:BR RS05570
gene id: 204722:BR_RS05570
uniprot id: P65976
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

204722:BR RS04780
gene id: 204722:BR_RS04780
uniprot id: Q8G0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane

204722:BR RS09605
gene id: 204722:BR_RS09605
uniprot id: Q8FY07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

204722:BR RS12580
gene id: 204722:BR_RS12580
uniprot id: A0A0H3G774
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

204722:BR RS00205
gene id: 204722:BR_RS00205
uniprot id: A0A0H3G9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Membrane

204722:BR RS06695
gene id: 204722:BR_RS06695
uniprot id: A0A0H3G3R1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

204722:BR RS14540
gene id: 204722:BR_RS14540
uniprot id: A0A0H3GC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

204722:BR RS07970
gene id: 204722:BR_RS07970
uniprot id: A0A0H3G8E9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

204722:BR RS06005
gene id: 204722:BR_RS06005
uniprot id: Q8G020
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

204722:BR RS02250
gene id: 204722:BR_RS02250
uniprot id: A0A0H3G276
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14200
gene id: 204722:BR_RS14200
uniprot id: Q8FVF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS09420
gene id: 204722:BR_RS09420
uniprot id: A0A0H3G9J7
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons.

204722:BR RS00695
gene id: 204722:BR_RS00695
uniprot id: Q8G308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

204722:BR RS00040
gene id: 204722:BR_RS00040
uniprot id: A0A0H3G537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS03645
gene id: 204722:BR_RS03645
uniprot id: Q8G1C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

204722:BR RS00070
gene id: 204722:BR_RS00070
uniprot id: A0A0H3G9C6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

204722:BR RS05305
gene id: 204722:BR_RS05305
uniprot id: A0A0H3G7T7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

204722:BR RS12405
gene id: 204722:BR_RS12405
uniprot id: A0A0H3GB21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

204722:BR RS00770
gene id: 204722:BR_RS00770
uniprot id: A0A0H3G1I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

204722:BR RS05675
gene id: 204722:BR_RS05675
uniprot id: Q8G082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

204722:BR RS13670
gene id: 204722:BR_RS13670
uniprot id: A0A0H3GFP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS15615
gene id: 204722:BR_RS15615
uniprot id: A0A0H3GC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

204722:BR RS11585
gene id: 204722:BR_RS11585
uniprot id: Q8FWV8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Induced in the absence of BepD and BepE.
messages: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.
messages: Periplasm
messages: Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepG.

204722:BR RS03625
gene id: 204722:BR_RS03625
uniprot id: Q8G1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family. Type 2 subfamily.
messages: Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
messages: Cell membrane
messages: Interacts with CtaB.

204722:BR RS11815
gene id: 204722:BR_RS11815
uniprot id: A0A0H3G663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

204722:BR RS09890
gene id: 204722:BR_RS09890
uniprot id: A0A0H3G988
names: Similarity
messages: Belongs to the Dps family.

204722:BR RS01835
gene id: 204722:BR_RS01835
uniprot id: Q8G2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

204722:BR RS05785
gene id: 204722:BR_RS05785
uniprot id: A0A0H3GC37
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

204722:BR RS11580
gene id: 204722:BR_RS11580
uniprot id: Q8FWV9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Induced in the absence of BepDE.
messages: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.
messages: Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF.
messages: Shows no differences in the resistance profile to different dyes, detergents and antimicrobials.

204722:BR RS07985
gene id: 204722:BR_RS07985
uniprot id: A0A0H3G4A3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

204722:BR RS05705
gene id: 204722:BR_RS05705
uniprot id: Q8G079
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

204722:BR RS06940
gene id: 204722:BR_RS06940
uniprot id: P64272
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

204722:BR RS12705
gene id: 204722:BR_RS12705
uniprot id: A0A0H3GB73
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14165
gene id: 204722:BR_RS14165
uniprot id: P65276
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

204722:BR RS02080
gene id: 204722:BR_RS02080
uniprot id: A0A0H3G641
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

204722:BR RS05670
gene id: 204722:BR_RS05670
uniprot id: Q8G083
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

204722:BR RS03280
gene id: 204722:BR_RS03280
uniprot id: Q8G1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

204722:BR RS04405
gene id: 204722:BR_RS04405
uniprot id: A0A0H3GBF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS03635
gene id: 204722:BR_RS03635
uniprot id: A0A0H3G319
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

204722:BR RS04610
gene id: 204722:BR_RS04610
uniprot id: A0A0H3G6S3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

204722:BR RS02265
gene id: 204722:BR_RS02265
uniprot id: A0A0H3G5J4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05710
gene id: 204722:BR_RS05710
uniprot id: Q8G078
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

204722:BR RS12430
gene id: 204722:BR_RS12430
uniprot id: A0A0H3G749
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

204722:BR RS05525
gene id: 204722:BR_RS05525
uniprot id: A0A0H3G7B3
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

204722:BR RS06975
gene id: 204722:BR_RS06975
uniprot id: A0A0H3G7Y3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

204722:BR RS07830
gene id: 204722:BR_RS07830
uniprot id: Q8FZ11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

204722:BR RS03560
gene id: 204722:BR_RS03560
uniprot id: A0A0H3G6X0
names: Similarity
messages: Belongs to the UPF0174 family.

204722:BR RS11470
gene id: 204722:BR_RS11470
uniprot id: A0A0H3GA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS11300
gene id: 204722:BR_RS11300
uniprot id: A0A0H3GA09
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

204722:BR RS05350
gene id: 204722:BR_RS05350
uniprot id: P0A3P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

204722:BR RS09130
gene id: 204722:BR_RS09130
uniprot id: A0A0H3G8X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

204722:BR RS12870
gene id: 204722:BR_RS12870
uniprot id: A0A0H3GFA9
names: Similarity
messages: Belongs to the DprA/Smf family.

204722:BR RS12905
gene id: 204722:BR_RS12905
uniprot id: P66216
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

204722:BR RS00380
gene id: 204722:BR_RS00380
uniprot id: P65723
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

204722:BR RS13850
gene id: 204722:BR_RS13850
uniprot id: Q8FVM4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

204722:BR RS07640
gene id: 204722:BR_RS07640
uniprot id: A0A0H3G454
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

204722:BR RS15105
gene id: 204722:BR_RS15105
uniprot id: A0A0H3GBW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS10025
gene id: 204722:BR_RS10025
uniprot id: A0A0H3G610
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

204722:BR RS07380
gene id: 204722:BR_RS07380
uniprot id: Q8FZ93
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes.

204722:BR RS15495
gene id: 204722:BR_RS15495
uniprot id: A0A0H3GCF0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03135
gene id: 204722:BR_RS03135
uniprot id: A0A0H3GAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

204722:BR RS08505
gene id: 204722:BR_RS08505
uniprot id: Q8FYL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

204722:BR RS15555
gene id: 204722:BR_RS15555
uniprot id: A0A0H3G7W7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS05895
gene id: 204722:BR_RS05895
uniprot id: A0A0H3G7F0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

204722:BR RS02200
gene id: 204722:BR_RS02200
uniprot id: Q8G256
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

204722:BR RS14510
gene id: 204722:BR_RS14510
uniprot id: A0A0H3G7I8
names: Function
messages: Component of an amino-acid transport system.

204722:BR RS08985
gene id: 204722:BR_RS08985
uniprot id: A0A0H3GDH6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS02945
gene id: 204722:BR_RS02945
uniprot id: P0DI93
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alphaproteobacteria porin family.
messages: Cell outer membrane
messages: Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.
messages: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
messages: Monomer.
messages: The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.

204722:BR RS13710
gene id: 204722:BR_RS13710
uniprot id: A0A0H3G7P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS07935
gene id: 204722:BR_RS07935
uniprot id: P66184
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

204722:BR RS12080
gene id: 204722:BR_RS12080
uniprot id: A0A0H3GAD4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS06630
gene id: 204722:BR_RS06630
uniprot id: A0A0H3G3Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

204722:BR RS10420
gene id: 204722:BR_RS10420
uniprot id: P0A3D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

204722:BR RS00575
gene id: 204722:BR_RS00575
uniprot id: A0A0H3G4S8
names: Similarity
messages: Belongs to the DEAD box helicase family.

204722:BR RS10135
gene id: 204722:BR_RS10135
uniprot id: A0A0H3G629
names: Cofactor
messages: Binds 1 phosphopantetheine covalently.

204722:BR RS10425
gene id: 204722:BR_RS10425
uniprot id: P0A3N9
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhizobiaceae omp10 lipoprotein family.
messages: Cell outer membrane
messages: Elicits an immune response in B.melitensis-infected sheep but not in B.abortus-infected cattle.

204722:BR RS08375
gene id: 204722:BR_RS08375
uniprot id: A0A0H3G5B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

204722:BR RS05725
gene id: 204722:BR_RS05725
uniprot id: P66325
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

204722:BR RS00155
gene id: 204722:BR_RS00155
uniprot id: Q8G3B7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

204722:BR RS09505
gene id: 204722:BR_RS09505
uniprot id: A0A0H3G9L4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

204722:BR RS09415
gene id: 204722:BR_RS09415
uniprot id: A0A0H3G929
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

204722:BR RS04795
gene id: 204722:BR_RS04795
uniprot id: A0A0H3G6W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

204722:BR RS12855
gene id: 204722:BR_RS12855
uniprot id: P65612
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

204722:BR RS07095
gene id: 204722:BR_RS07095
uniprot id: A0A0H3G801
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

204722:BR RS04865
gene id: 204722:BR_RS04865
uniprot id: A0A0H3GBP1
names: Similarity
messages: Belongs to the DEAD box helicase family.

204722:BR RS12510
gene id: 204722:BR_RS12510
uniprot id: A0A0H3GAK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

204722:BR RS11360
gene id: 204722:BR_RS11360
uniprot id: A0A0H3GA18
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 copper ion per subunit.
messages: Periplasm

204722:BR RS11630
gene id: 204722:BR_RS11630
uniprot id: A0A0H3GA67
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS03105
gene id: 204722:BR_RS03105
uniprot id: A0A0H3G2R5
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

204722:BR RS06850
gene id: 204722:BR_RS06850
uniprot id: A0A0H3G4J5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

204722:BR RS05595
gene id: 204722:BR_RS05595
uniprot id: Q8G095
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

204722:BR RS07285
gene id: 204722:BR_RS07285
uniprot id: A0A0H3G8L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS13490
gene id: 204722:BR_RS13490
uniprot id: A0A0H3GB32
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS14680
gene id: 204722:BR_RS14680
uniprot id: Q8FV59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

204722:BR RS01365
gene id: 204722:BR_RS01365
uniprot id: Q8G2M8
names: Function
messages: Represses expression of bepDE.

204722:BR RS05325
gene id: 204722:BR_RS05325
uniprot id: A0A0H3G3C1
names: Similarity
messages: Belongs to the citrate synthase family.

204722:BR RS08695
gene id: 204722:BR_RS08695
uniprot id: P64187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

204722:BR RS02110
gene id: 204722:BR_RS02110
uniprot id: A0A0H3G5G8
names: Similarity
messages: Belongs to the fabD family.

204722:BR RS04225
gene id: 204722:BR_RS04225
uniprot id: A0A0H3G6J7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
messages: Homotetramer formed by a dimer of dimers.

204722:BR RS03325
gene id: 204722:BR_RS03325
uniprot id: A0A0H3G6S1
names: Function
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

204722:BR RS01795
gene id: 204722:BR_RS01795
uniprot id: P0A4E0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

204722:BR RS08160
gene id: 204722:BR_RS08160
uniprot id: A0A0H3G910
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

204722:BR RS13205
gene id: 204722:BR_RS13205
uniprot id: A0A0H3GAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

204722:BR RS03575
gene id: 204722:BR_RS03575
uniprot id: Q8G1E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

204722:BR RS15050
gene id: 204722:BR_RS15050
uniprot id: Q8FUZ0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

204722:BR RS06350
gene id: 204722:BR_RS06350
uniprot id: A0A0H3G3L8
names: Similarity
messages: Belongs to the PhzF family.

204722:BR RS08380
gene id: 204722:BR_RS08380
uniprot id: P66434
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

204722:BR RS01320
gene id: 204722:BR_RS01320
uniprot id: A0A0H3G5R0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

204722:BR RS04930
gene id: 204722:BR_RS04930
uniprot id: A0A0H3G3R5
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

204722:BR RS12460
gene id: 204722:BR_RS12460
uniprot id: A0A0H3G6F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

204722:BR RS11610
gene id: 204722:BR_RS11610
uniprot id: Q8FWV5
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

204722:BR RS01270
gene id: 204722:BR_RS01270
uniprot id: Q8G2P7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

204722:BR RS13355
gene id: 204722:BR_RS13355
uniprot id: A0A0H3GB07
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS09090
gene id: 204722:BR_RS09090
uniprot id: A0A0H3G4U0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

204722:BR RS12760
gene id: 204722:BR_RS12760
uniprot id: A0A0H3GB81
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

204722:BR RS09540
gene id: 204722:BR_RS09540
uniprot id: Q8FY19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

204722:BR RS01775
gene id: 204722:BR_RS01775
uniprot id: Q8G2E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

204722:BR RS11545
gene id: 204722:BR_RS11545
uniprot id: A0A0H3GAN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

204722:BR RS12515
gene id: 204722:BR_RS12515
uniprot id: A0A0H3G763
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Homohexamer. Forms a ring that surrounds DNA.

204722:BR RS01180
gene id: 204722:BR_RS01180
uniprot id: P67568
names: Similarity
messages: Belongs to the UPF0262 family.

204722:BR RS08935
gene id: 204722:BR_RS08935
uniprot id: Q8FYE2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

204722:BR RS12390
gene id: 204722:BR_RS12390
uniprot id: A0A0H3GF30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

204722:BR RS15685
gene id: 204722:BR_RS15685
uniprot id: Q8FUM7
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS01305
gene id: 204722:BR_RS01305
uniprot id: A0A0H3G9X2
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

204722:BR RS00970
gene id: 204722:BR_RS00970
uniprot id: A0A0H3G1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS09580
gene id: 204722:BR_RS09580
uniprot id: Q8FY11
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

204722:BR RS08500
gene id: 204722:BR_RS08500
uniprot id: Q8FYL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

204722:BR RS14175
gene id: 204722:BR_RS14175
uniprot id: A0A0H3GBH7
names: Similarity
messages: Belongs to the OsmC/Ohr family.

204722:BR RS14365
gene id: 204722:BR_RS14365
uniprot id: Q8FVC0
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

204722:BR RS06145
gene id: 204722:BR_RS06145
uniprot id: A0A0H3G4B3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10575
gene id: 204722:BR_RS10575
uniprot id: A0A0H3GE70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

204722:BR RS09220
gene id: 204722:BR_RS09220
uniprot id: A0A0H3GDL2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

204722:BR RS07835
gene id: 204722:BR_RS07835
uniprot id: A0A0H3G484
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

204722:BR RS08110
gene id: 204722:BR_RS08110
uniprot id: Q8FYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

204722:BR RS14840
gene id: 204722:BR_RS14840
uniprot id: Q8FV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

204722:BR RS10590
gene id: 204722:BR_RS10590
uniprot id: A0A0H3GA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS07605
gene id: 204722:BR_RS07605
uniprot id: A0A0H3G8R7
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS01050
gene id: 204722:BR_RS01050
uniprot id: A0A0H3G1M9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

204722:BR RS00065
gene id: 204722:BR_RS00065
uniprot id: Q8G3D4
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS03590
gene id: 204722:BR_RS03590
uniprot id: A0A0H3G690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

204722:BR RS14535
gene id: 204722:BR_RS14535
uniprot id: A0A0H3G7J3
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

204722:BR RS06000
gene id: 204722:BR_RS06000
uniprot id: A0A0H3GC71
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

204722:BR RS02515
gene id: 204722:BR_RS02515
uniprot id: Q8G204
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

204722:BR RS02840
gene id: 204722:BR_RS02840
uniprot id: Q8G1U0
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

204722:BR RS12520
gene id: 204722:BR_RS12520
uniprot id: A0A0H3GF58
names: Similarity
messages: Belongs to the peptidase S58 family.

204722:BR RS03245
gene id: 204722:BR_RS03245
uniprot id: A0A0H3G2L1
names: Similarity
messages: Belongs to the RNase T2 family.

204722:BR RS12000
gene id: 204722:BR_RS12000
uniprot id: A0A0H3G687
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS06620
gene id: 204722:BR_RS06620
uniprot id: Q8FZP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

204722:BR RS01595
gene id: 204722:BR_RS01595
uniprot id: A0A0H3GA17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

204722:BR RS12555
gene id: 204722:BR_RS12555
uniprot id: A0A0H3GAL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS09530
gene id: 204722:BR_RS09530
uniprot id: P63825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

204722:BR RS09105
gene id: 204722:BR_RS09105
uniprot id: A0A0H3G5M7
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04980
gene id: 204722:BR_RS04980
uniprot id: Q8G0L3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS08075
gene id: 204722:BR_RS08075
uniprot id: A0A0H3G536
names: Similarity
messages: Belongs to the pyruvate kinase family.

204722:BR RS03765
gene id: 204722:BR_RS03765
uniprot id: A0A0H3G2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

204722:BR RS05645
gene id: 204722:BR_RS05645
uniprot id: Q8G087
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

204722:BR RS14850
gene id: 204722:BR_RS14850
uniprot id: P59296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

204722:BR RS14275
gene id: 204722:BR_RS14275
uniprot id: A0A0H3GBY9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS06080
gene id: 204722:BR_RS06080
uniprot id: Q8G005
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

204722:BR RS09485
gene id: 204722:BR_RS09485
uniprot id: Q8CY34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

204722:BR RS06600
gene id: 204722:BR_RS06600
uniprot id: Q8FZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

204722:BR RS10520
gene id: 204722:BR_RS10520
uniprot id: A0A0H3G9H6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS10945
gene id: 204722:BR_RS10945
uniprot id: Q8FX90
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

204722:BR RS06390
gene id: 204722:BR_RS06390
uniprot id: Q8FZT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

204722:BR RS05120
gene id: 204722:BR_RS05120
uniprot id: Q8G0J1
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

204722:BR RS11190
gene id: 204722:BR_RS11190
uniprot id: A0A0H3G6J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

204722:BR RS13590
gene id: 204722:BR_RS13590
uniprot id: A0A0H3GB51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
messages: Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).
messages: Homodimer or monomer when oxidized or reduced, respectively.
messages: chloroplast

204722:BR RS10925
gene id: 204722:BR_RS10925
uniprot id: Q8FX92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

204722:BR RS10360
gene id: 204722:BR_RS10360
uniprot id: Q9RPX9
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbL/VirB6 family.
messages: Cell inner membrane
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS15655
gene id: 204722:BR_RS15655
uniprot id: Q8FUN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm
messages: Probably part of an ABC transporter complex.
messages: The complex is composed of two ATP-binding proteins (BRA1187), two transmembrane proteins (BRA1188) and a solute-binding protein (BRA1186).

204722:BR RS11940
gene id: 204722:BR_RS11940
uniprot id: Q8FWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA0404 and BRA0405), two transmembrane proteins (BRA0407 and BRA0408) and a solute-binding protein (BRA0409).

204722:BR RS11070
gene id: 204722:BR_RS11070
uniprot id: A0A0H3G6H0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS15400
gene id: 204722:BR_RS15400
uniprot id: A0A0H3GGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

204722:BR RS14420
gene id: 204722:BR_RS14420
uniprot id: A0A0H3GG07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS15675
gene id: 204722:BR_RS15675
uniprot id: Q8FUN0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Heme transporter.
messages: Induced in absence of iron.

204722:BR RS11495
gene id: 204722:BR_RS11495
uniprot id: A0A0H3G6S0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

204722:BR RS02120
gene id: 204722:BR_RS02120
uniprot id: P63438
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

204722:BR RS05100
gene id: 204722:BR_RS05100
uniprot id: A0A0H3G719
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

204722:BR RS11875
gene id: 204722:BR_RS11875
uniprot id: A0A0H3GEV5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS05540
gene id: 204722:BR_RS05540
uniprot id: A0A0H3GC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS15605
gene id: 204722:BR_RS15605
uniprot id: A0A0H3GGG5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS14205
gene id: 204722:BR_RS14205
uniprot id: Q8FVF2
names: Similarity
messages: Belongs to the UPF0434 family.

204722:BR RS00160
gene id: 204722:BR_RS00160
uniprot id: P67261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

204722:BR RS14295
gene id: 204722:BR_RS14295
uniprot id: A0A0H3G7F5
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

204722:BR RS08690
gene id: 204722:BR_RS08690
uniprot id: Q8FYI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

204722:BR RS03845
gene id: 204722:BR_RS03845
uniprot id: A0A0H3G2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS13875
gene id: 204722:BR_RS13875
uniprot id: Q8FVM0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

204722:BR RS02520
gene id: 204722:BR_RS02520
uniprot id: A0A0H3G6E5
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

204722:BR RS05690
gene id: 204722:BR_RS05690
uniprot id: P59180
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

204722:BR RS09045
gene id: 204722:BR_RS09045
uniprot id: A0A0H3G9D5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

204722:BR RS03060
gene id: 204722:BR_RS03060
uniprot id: Q8G1P8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

204722:BR RS08700
gene id: 204722:BR_RS08700
uniprot id: A0A0H3G4M9
names: Similarity
messages: Belongs to the YciI family.

204722:BR RS02310
gene id: 204722:BR_RS02310
uniprot id: A0A0H3G261
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the reversible phosphorylation of pyruvate and phosphate.

204722:BR RS11995
gene id: 204722:BR_RS11995
uniprot id: A0A0H3GEW5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

204722:BR RS05485
gene id: 204722:BR_RS05485
uniprot id: Q8G0B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

204722:BR RS03600
gene id: 204722:BR_RS03600
uniprot id: A0A0H3G6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

204722:BR RS05090
gene id: 204722:BR_RS05090
uniprot id: P63815
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

204722:BR RS01900
gene id: 204722:BR_RS01900
uniprot id: A0A0H3G217
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

204722:BR RS04365
gene id: 204722:BR_RS04365
uniprot id: Q8G0Y6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host.
messages: Mutation strongly affects resistance to bile salts and toxic chemicals, and significantly decreases the resistance to antibiotics such as erythromycin, ampicillin, tetracycline, and norfloxacin. The mutant also has attenuated effects in the mouse model of infection.
messages: Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepD and BepE or with BepF and BepG.

204722:BR RS05885
gene id: 204722:BR_RS05885
uniprot id: Q8G044
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

204722:BR RS12125
gene id: 204722:BR_RS12125
uniprot id: Q8FWK8
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

204722:BR RS13345
gene id: 204722:BR_RS13345
uniprot id: Q8FVW4
names: Function
names: Similarity
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.

204722:BR RS02025
gene id: 204722:BR_RS02025
uniprot id: Q8G290
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

204722:BR RS09610
gene id: 204722:BR_RS09610
uniprot id: P64352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

204722:BR RS10720
gene id: 204722:BR_RS10720
uniprot id: A0A0H3G6C0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS09265
gene id: 204722:BR_RS09265
uniprot id: A0A0H3GDM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

204722:BR RS01265
gene id: 204722:BR_RS01265
uniprot id: Q8G2P8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when inoculated in BALB/c mice by gavage.
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

204722:BR RS07845
gene id: 204722:BR_RS07845
uniprot id: P0A3S8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The N-terminus is blocked.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

204722:BR RS08815
gene id: 204722:BR_RS08815
uniprot id: Q8CY35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

204722:BR RS05255
gene id: 204722:BR_RS05255
uniprot id: Q8G0G3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

204722:BR RS14065
gene id: 204722:BR_RS14065
uniprot id: A0A0H3GFW5
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS12135
gene id: 204722:BR_RS12135
uniprot id: A0A0H3GAX2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS03005
gene id: 204722:BR_RS03005
uniprot id: Q8CY42
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the RelA/SpoT family.
messages: Cells show morphological abnormalities such as branching and swelling forms during vegetative growth. It is unable to persist during stationary phase, presumably because of nutrient limitation occurring during this growth phase. It shows an important growth defect in human HeLa cells and in ovine macrophages MOCL3. At four weeks post infection the number of viable bacteria (deletion mutant) in mouse spleen is markedly reduced compared to the wild-type. The deletion mutant shows very low levels or absence of VirB at all time points of growth.
messages: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. It is necessary for persistence in mice, essential for intracellular growth of Brucella and required for expression of the type IV secretion system VirB and therefore plays a role in adaptation of Brucella to its intracellular host environment.

204722:BR RS09695
gene id: 204722:BR_RS09695
uniprot id: Q8FXY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

204722:BR RS12535
gene id: 204722:BR_RS12535
uniprot id: A0A0H3GB48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS11350
gene id: 204722:BR_RS11350
uniprot id: A0A0H3GEM2
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

204722:BR RS15140
gene id: 204722:BR_RS15140
uniprot id: A0A0H3GBW6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS01750
gene id: 204722:BR_RS01750
uniprot id: A0A0H3GA45
names: Similarity
messages: Belongs to the YfgM family.

204722:BR RS13540
gene id: 204722:BR_RS13540
uniprot id: A0A0H3GFM4
names: Similarity
messages: Belongs to the RutC family.

204722:BR RS11050
gene id: 204722:BR_RS11050
uniprot id: A0A0H3G9T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

204722:BR RS11615
gene id: 204722:BR_RS11615
uniprot id: Q8FWV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeA family.
messages: Periplasm
messages: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.

204722:BR RS09075
gene id: 204722:BR_RS09075
uniprot id: Q8FYB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

204722:BR RS10915
gene id: 204722:BR_RS10915
uniprot id: Q8FX93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS04275
gene id: 204722:BR_RS04275
uniprot id: Q8G105
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

204722:BR RS09975
gene id: 204722:BR_RS09975
uniprot id: P59876
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

204722:BR RS07435
gene id: 204722:BR_RS07435
uniprot id: A0A0H3GCT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

204722:BR RS06585
gene id: 204722:BR_RS06585
uniprot id: A0A0H3G893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

204722:BR RS10230
gene id: 204722:BR_RS10230
uniprot id: A0A0H3G9D7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

204722:BR RS00825
gene id: 204722:BR_RS00825
uniprot id: P67229
names: Similarity
messages: Belongs to the UPF0102 family.

204722:BR RS02130
gene id: 204722:BR_RS02130
uniprot id: A0A0H3G228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

204722:BR RS03080
gene id: 204722:BR_RS03080
uniprot id: A0A0H3G2Q9
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

204722:BR RS06565
gene id: 204722:BR_RS06565
uniprot id: A0A0H3G4G4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

204722:BR RS00985
gene id: 204722:BR_RS00985
uniprot id: A0A0H3G1M1
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.

204722:BR RS00405
gene id: 204722:BR_RS00405
uniprot id: A0A0H3G1B3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS11525
gene id: 204722:BR_RS11525
uniprot id: P65362
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

204722:BR RS03755
gene id: 204722:BR_RS03755
uniprot id: Q8G1A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS14900
gene id: 204722:BR_RS14900
uniprot id: A0A0H3GBT8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

204722:BR RS12805
gene id: 204722:BR_RS12805
uniprot id: Q8FW73
names: Function
names: PTM
messages: FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark.
messages: Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host. This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages (By similarity).

204722:BR RS04000
gene id: 204722:BR_RS04000
uniprot id: Q8G155
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

204722:BR RS02870
gene id: 204722:BR_RS02870
uniprot id: A0A0H3G5W0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

204722:BR RS06660
gene id: 204722:BR_RS06660
uniprot id: A0A0H3G3Q6
names: Similarity
messages: Belongs to the virb1 family.

204722:BR RS01715
gene id: 204722:BR_RS01715
uniprot id: A0A0H3GA38
names: Cofactor
messages: Binds 1 zinc ion per subunit.

204722:BR RS10320
gene id: 204722:BR_RS10320
uniprot id: A0A0H3G666
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08275
gene id: 204722:BR_RS08275
uniprot id: Q8FYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

204722:BR RS03235
gene id: 204722:BR_RS03235
uniprot id: Q45689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Omp25/RopB family.
messages: Cell outer membrane

204722:BR RS12915
gene id: 204722:BR_RS12915
uniprot id: Q8FW53
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS (By similarity).
messages: Interacts with DivL, PleC, DivJ and PdhS.

204722:BR RS01770
gene id: 204722:BR_RS01770
uniprot id: A0A0H3G1X9
names: Function
names: Similarity
messages: A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.
messages: Belongs to the bacterial AtpI family.

204722:BR RS00035
gene id: 204722:BR_RS00035
uniprot id: A0A0H3G4I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

204722:BR RS12325
gene id: 204722:BR_RS12325
uniprot id: A0A0H3GAG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

204722:BR RS10105
gene id: 204722:BR_RS10105
uniprot id: A0A0H3G9U5
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14800
gene id: 204722:BR_RS14800
uniprot id: A0A0H3GG74
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS15035
gene id: 204722:BR_RS15035
uniprot id: Q8FUZ3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

204722:BR RS03725
gene id: 204722:BR_RS03725
uniprot id: A0A0H3G2S7
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

204722:BR RS04285
gene id: 204722:BR_RS04285
uniprot id: A0A0H3G3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

204722:BR RS07950
gene id: 204722:BR_RS07950
uniprot id: A0A0H3G8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

204722:BR RS06420
gene id: 204722:BR_RS06420
uniprot id: Q8CY40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

204722:BR RS05680
gene id: 204722:BR_RS05680
uniprot id: P66165
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

204722:BR RS00210
gene id: 204722:BR_RS00210
uniprot id: A0A0H3G1A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

204722:BR RS07620
gene id: 204722:BR_RS07620
uniprot id: A0A0H3G8S0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

204722:BR RS09615
gene id: 204722:BR_RS09615
uniprot id: P63809
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

204722:BR RS05635
gene id: 204722:BR_RS05635
uniprot id: P66571
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

204722:BR RS09950
gene id: 204722:BR_RS09950
uniprot id: P67213
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

204722:BR RS00030
gene id: 204722:BR_RS00030
uniprot id: A0A0H3G181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS00345
gene id: 204722:BR_RS00345
uniprot id: Q8G376
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

204722:BR RS13545
gene id: 204722:BR_RS13545
uniprot id: A0A0H3G6Z5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M81 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC).

204722:BR RS09410
gene id: 204722:BR_RS09410
uniprot id: A0A0H3G4Z3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS05370
gene id: 204722:BR_RS05370
uniprot id: Q8G0D9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

204722:BR RS09210
gene id: 204722:BR_RS09210
uniprot id: Q8FY85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell inner membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.

204722:BR RS00015
gene id: 204722:BR_RS00015
uniprot id: Q8G3E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

204722:BR RS09065
gene id: 204722:BR_RS09065
uniprot id: A0A0H3G8X0
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

204722:BR RS14600
gene id: 204722:BR_RS14600
uniprot id: A0A0H3G855
names: Similarity
messages: Belongs to the AlaDH/PNT family.

204722:BR RS00845
gene id: 204722:BR_RS00845
uniprot id: A0A0H3G4W7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

204722:BR RS10900
gene id: 204722:BR_RS10900
uniprot id: A0A0H3GEC8
names: Similarity
messages: Belongs to the YkuD family.

204722:BR RS04465
gene id: 204722:BR_RS04465
uniprot id: A0A0H3G3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

204722:BR RS14920
gene id: 204722:BR_RS14920
uniprot id: A0A0H3G7P6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

204722:BR RS14115
gene id: 204722:BR_RS14115
uniprot id: A0A0H3G7C6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

204722:BR RS10685
gene id: 204722:BR_RS10685
uniprot id: A0A0H3GE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

204722:BR RS09480
gene id: 204722:BR_RS09480
uniprot id: Q8FY28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

204722:BR RS12995
gene id: 204722:BR_RS12995
uniprot id: A0A0H3GFD2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

204722:BR RS06060
gene id: 204722:BR_RS06060
uniprot id: A0A0H3GC77
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

204722:BR RS03175
gene id: 204722:BR_RS03175
uniprot id: Q8G1M4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

204722:BR RS05740
gene id: 204722:BR_RS05740
uniprot id: Q8G074
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

204722:BR RS05685
gene id: 204722:BR_RS05685
uniprot id: Q8G081
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

204722:BR RS05360
gene id: 204722:BR_RS05360
uniprot id: Q8G0E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane

204722:BR RS05800
gene id: 204722:BR_RS05800
uniprot id: P64025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

204722:BR RS02885
gene id: 204722:BR_RS02885
uniprot id: A0A0H3GAQ7
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

204722:BR RS00670
gene id: 204722:BR_RS00670
uniprot id: Q8G312
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

204722:BR RS07635
gene id: 204722:BR_RS07635
uniprot id: A0A0H3GCW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

204722:BR RS00225
gene id: 204722:BR_RS00225
uniprot id: A0A0H3G9E5
names: Subcellular Location Annotation
messages: Cell outer membrane

204722:BR RS01525
gene id: 204722:BR_RS01525
uniprot id: A0A0H3G563
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS08055
gene id: 204722:BR_RS08055
uniprot id: Q8FYW3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

204722:BR RS05610
gene id: 204722:BR_RS05610
uniprot id: P66382
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

204722:BR RS05355
gene id: 204722:BR_RS05355
uniprot id: A0A0H3G415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

204722:BR RS10650
gene id: 204722:BR_RS10650
uniprot id: A0A0H3G5G5
names: Function
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.

204722:BR RS09360
gene id: 204722:BR_RS09360
uniprot id: A0A0H3G4Y3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

204722:BR RS13565
gene id: 204722:BR_RS13565
uniprot id: A0A0H3GB46
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS11285
gene id: 204722:BR_RS11285
uniprot id: A0A0H3G6N2
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10745
gene id: 204722:BR_RS10745
uniprot id: A0A0H3G6C4
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

204722:BR RS03735
gene id: 204722:BR_RS03735
uniprot id: A0A0H3G6Z7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS00535
gene id: 204722:BR_RS00535
uniprot id: A0A0H3G5B6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

204722:BR RS06720
gene id: 204722:BR_RS06720
uniprot id: A0A0H3G3R8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

204722:BR RS00120
gene id: 204722:BR_RS00120
uniprot id: Q8G3C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

204722:BR RS14675
gene id: 204722:BR_RS14675
uniprot id: P0A4R1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

204722:BR RS13020
gene id: 204722:BR_RS13020
uniprot id: A0A0H3GFD8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

204722:BR RS13090
gene id: 204722:BR_RS13090
uniprot id: A0A0H3GBD2
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS08280
gene id: 204722:BR_RS08280
uniprot id: Q8FYR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

204722:BR RS10535
gene id: 204722:BR_RS10535
uniprot id: A0A0H3GE59
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS07740
gene id: 204722:BR_RS07740
uniprot id: A0A0H3G8T7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS12770
gene id: 204722:BR_RS12770
uniprot id: Q8CY30
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS06460
gene id: 204722:BR_RS06460
uniprot id: P67043
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS10960
gene id: 204722:BR_RS10960
uniprot id: P0A343
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: By heat shock.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

204722:BR RS09755
gene id: 204722:BR_RS09755
uniprot id: A0A0H3GDT6
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05615
gene id: 204722:BR_RS05615
uniprot id: Q8G092
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

204722:BR RS13085
gene id: 204722:BR_RS13085
uniprot id: A0A0H3GAV3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS04205
gene id: 204722:BR_RS04205
uniprot id: Q8G120
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

204722:BR RS09865
gene id: 204722:BR_RS09865
uniprot id: A0A0H3GDU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

204722:BR RS10665
gene id: 204722:BR_RS10665
uniprot id: A0A0H3G6A9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

204722:BR RS12525
gene id: 204722:BR_RS12525
uniprot id: A0A0H3G6G8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS02060
gene id: 204722:BR_RS02060
uniprot id: A0A0H3G635
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

204722:BR RS04195
gene id: 204722:BR_RS04195
uniprot id: A0A0H3G6I9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

204722:BR RS11380
gene id: 204722:BR_RS11380
uniprot id: A0A0H3G5Y7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS02360
gene id: 204722:BR_RS02360
uniprot id: A0A0H3G295
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS10300
gene id: 204722:BR_RS10300
uniprot id: A0A0H3G662
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

204722:BR RS10055
gene id: 204722:BR_RS10055
uniprot id: Q8FXR6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

204722:BR RS11465
gene id: 204722:BR_RS11465
uniprot id: A0A0H3G606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS14390
gene id: 204722:BR_RS14390
uniprot id: Q8FVB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

204722:BR RS00500
gene id: 204722:BR_RS00500
uniprot id: A0A0H3G5B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

204722:BR RS08755
gene id: 204722:BR_RS08755
uniprot id: A0A0H3G4N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

204722:BR RS06295
gene id: 204722:BR_RS06295
uniprot id: Q8FZV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when inoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

204722:BR RS06895
gene id: 204722:BR_RS06895
uniprot id: A0A0H3G8E5
names: Subcellular Location Annotation
messages: Cytoplasm

204722:BR RS03940
gene id: 204722:BR_RS03940
uniprot id: P63451
names: Function
names: PTM
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).
messages: Cytoplasm

204722:BR RS02540
gene id: 204722:BR_RS02540
uniprot id: Q8G1Z8
names: Function
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.

204722:BR RS06205
gene id: 204722:BR_RS06205
uniprot id: A0A0H3G3K2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS07940
gene id: 204722:BR_RS07940
uniprot id: P67174
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

204722:BR RS05050
gene id: 204722:BR_RS05050
uniprot id: A0A0H3G379
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

204722:BR RS08875
gene id: 204722:BR_RS08875
uniprot id: Q8FYF4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

204722:BR RS05235
gene id: 204722:BR_RS05235
uniprot id: A0A0H3GBU9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

204722:BR RS05340
gene id: 204722:BR_RS05340
uniprot id: P65321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

204722:BR RS15475
gene id: 204722:BR_RS15475
uniprot id: A0A0H3GGE2
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Cell surface
messages: Deletion mutant is impaired in the adhesion of B.suis to immobilized fibronectin and host cells.
messages: Fibronectin-binding protein, which is involved in adhesion to host cells and in the infective process. Mediates the binding of B.suis to the extracellular matrix and to non-phagocytic cells via cell-associated fibronectin.
messages: The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface.

204722:BR RS00265
gene id: 204722:BR_RS00265
uniprot id: A0A0H3G192
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

204722:BR RS06515
gene id: 204722:BR_RS06515
uniprot id: Q8FZR2
names: Similarity
messages: Belongs to the UPF0303 family.

204722:BR RS11340
gene id: 204722:BR_RS11340
uniprot id: A0A0H3GAJ3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS07790
gene id: 204722:BR_RS07790
uniprot id: P65879
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

204722:BR RS04850
gene id: 204722:BR_RS04850
uniprot id: Q8G0P0
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

204722:BR RS01375
gene id: 204722:BR_RS01375
uniprot id: Q8G2M6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics.
messages: Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepD.
messages: Repressed by BepR.
messages: Shows increased sensitivity to deoxycholate, ethidium bromide and crystal violet.

204722:BR RS14590
gene id: 204722:BR_RS14590
uniprot id: A0A0H3GBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

204722:BR RS13095
gene id: 204722:BR_RS13095
uniprot id: A0A0H3G7E6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS12740
gene id: 204722:BR_RS12740
uniprot id: Q8FW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

204722:BR RS14695
gene id: 204722:BR_RS14695
uniprot id: A0A0H3G7L9
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS11680
gene id: 204722:BR_RS11680
uniprot id: A0A0H3GA74
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS15265
gene id: 204722:BR_RS15265
uniprot id: A0A0H3GBX7
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

204722:BR RS04580
gene id: 204722:BR_RS04580
uniprot id: A0A0H3G6R8
names: Similarity
messages: Belongs to the ArsC family.

204722:BR RS10015
gene id: 204722:BR_RS10015
uniprot id: A0A0H3G9A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

204722:BR RS13820
gene id: 204722:BR_RS13820
uniprot id: A0A0H3G744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS12500
gene id: 204722:BR_RS12500
uniprot id: A0A0H3GF53
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

204722:BR RS09395
gene id: 204722:BR_RS09395
uniprot id: A0A0H3G9J2
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

204722:BR RS03150
gene id: 204722:BR_RS03150
uniprot id: P65681
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

204722:BR RS01550
gene id: 204722:BR_RS01550
uniprot id: P65655
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

204722:BR RS02650
gene id: 204722:BR_RS02650
uniprot id: A0A0H3G2C7
names: Similarity
messages: Belongs to the SufE family.

204722:BR RS00545
gene id: 204722:BR_RS00545
uniprot id: A0A0H3G9J4
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

204722:BR RS03295
gene id: 204722:BR_RS03295
uniprot id: A0A0H3G636
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

204722:BR RS13530
gene id: 204722:BR_RS13530
uniprot id: Q8FVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (Probable).
messages: The complex is composed of two ATP-binding proteins (BRA0745), two transmembrane proteins (BRA0749) and a solute-binding protein (BRA0748).

204722:BR RS10255
gene id: 204722:BR_RS10255
uniprot id: Q8FXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity).

204722:BR RS01570
gene id: 204722:BR_RS01570
uniprot id: Q8G2I3
names: Function
names: Similarity
messages: Belongs to the proline racemase family.
messages: Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C) (PubMed:24980702). Displays neither proline racemase activity nor 4-hydroxyproline 2-epimerase activity (PubMed:17849014, PubMed:24980702).

204722:BR RS14470
gene id: 204722:BR_RS14470
uniprot id: A0A0H3G836
names: Similarity
messages: Belongs to the TPP enzyme family.

204722:BR RS12410
gene id: 204722:BR_RS12410
uniprot id: A0A0H3G746
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

204722:BR RS15020
gene id: 204722:BR_RS15020
uniprot id: A0A0H3GC89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS12800
gene id: 204722:BR_RS12800
uniprot id: A0A0H3GB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BA14k family.
messages: Cell membrane
messages: Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport.
messages: Membrane

204722:BR RS04340
gene id: 204722:BR_RS04340
uniprot id: A0A0H3G796
names: Similarity
messages: Belongs to the DEAD box helicase family.

204722:BR RS15145
gene id: 204722:BR_RS15145
uniprot id: A0A0H3GCA6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

204722:BR RS14775
gene id: 204722:BR_RS14775
uniprot id: A0A0H3GG69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS03655
gene id: 204722:BR_RS03655
uniprot id: A0A0H3GB40
names: Similarity
messages: Belongs to the thioesterase PaaI family.

204722:BR RS07085
gene id: 204722:BR_RS07085
uniprot id: Q8FZE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

204722:BR RS02015
gene id: 204722:BR_RS02015
uniprot id: Q8G292
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

204722:BR RS08515
gene id: 204722:BR_RS08515
uniprot id: A0A0H3G5D6
names: Function
messages: Involved in the transposition of the insertion sequence.

204722:BR RS14395
gene id: 204722:BR_RS14395
uniprot id: Q8FVB4
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

204722:BR RS14925
gene id: 204722:BR_RS14925
uniprot id: P67385
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

204722:BR RS05535
gene id: 204722:BR_RS05535
uniprot id: P63632
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

204722:BR RS06580
gene id: 204722:BR_RS06580
uniprot id: A0A0H3G7S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

204722:BR RS04425
gene id: 204722:BR_RS04425
uniprot id: Q8G0X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

204722:BR RS04875
gene id: 204722:BR_RS04875
uniprot id: A0A0H3G6Y4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

204722:BR RS05600
gene id: 204722:BR_RS05600
uniprot id: Q8G094
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

204722:BR RS05930
gene id: 204722:BR_RS05930
uniprot id: Q8G034
names: Similarity
messages: Belongs to the SfsA family.

204722:BR RS06560
gene id: 204722:BR_RS06560
uniprot id: Q8FZQ3
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

204722:BR RS09850
gene id: 204722:BR_RS09850
uniprot id: A0A0H3G9Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

204722:BR RS01885
gene id: 204722:BR_RS01885
uniprot id: A0A0H3GA68
names: Similarity
messages: Belongs to the RelE toxin family.

204722:BR RS13810
gene id: 204722:BR_RS13810
uniprot id: Q9AL83
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Homotetramer.
messages: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity).

204722:BR RS12305
gene id: 204722:BR_RS12305
uniprot id: A0A0H3GB00
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

204722:BR RS02295
gene id: 204722:BR_RS02295
uniprot id: A0A0H3G682
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

204722:BR RS10940
gene id: 204722:BR_RS10940
uniprot id: A0A0H3GA93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

204722:BR RS11415
gene id: 204722:BR_RS11415
uniprot id: A0A0H3GEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cell outer membrane
messages: Membrane

204722:BR RS10790
gene id: 204722:BR_RS10790
uniprot id: Q8FXC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

204722:BR RS07175
gene id: 204722:BR_RS07175
uniprot id: A0A0H3G811
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

204722:BR RS02855
gene id: 204722:BR_RS02855
uniprot id: A0A0H3G2L9
names: Similarity
messages: Belongs to the peptidase M1 family.

204722:BR RS13315
gene id: 204722:BR_RS13315
uniprot id: A0A0H3G6U7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS02030
gene id: 204722:BR_RS02030
uniprot id: A0A0H3G631
names: Similarity
messages: Belongs to the LOG family.

204722:BR RS13115
gene id: 204722:BR_RS13115
uniprot id: Q8FW10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

204722:BR RS09345
gene id: 204722:BR_RS09345
uniprot id: Q8FY57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

204722:BR RS14480
gene id: 204722:BR_RS14480
uniprot id: Q8FV99
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S12 family.
messages: Homodimer.
messages: Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
messages: Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate.

204722:BR RS01790
gene id: 204722:BR_RS01790
uniprot id: Q8G2D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

204722:BR RS02990
gene id: 204722:BR_RS02990
uniprot id: A0A0H3G2H7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

204722:BR RS01415
gene id: 204722:BR_RS01415
uniprot id: Q8G2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

204722:BR RS14340
gene id: 204722:BR_RS14340
uniprot id: A0A0H3GFZ8
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

204722:BR RS00885
gene id: 204722:BR_RS00885
uniprot id: A0A0H3G1K5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS04640
gene id: 204722:BR_RS04640
uniprot id: A0A0H3G7E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

204722:BR RS00520
gene id: 204722:BR_RS00520
uniprot id: Q8G340
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

204722:BR RS01395
gene id: 204722:BR_RS01395
uniprot id: A0A0H3G9Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

204722:BR RS06965
gene id: 204722:BR_RS06965
uniprot id: A0A0H3GCK7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

204722:BR RS00440
gene id: 204722:BR_RS00440
uniprot id: A0A0H3G1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

204722:BR RS04665
gene id: 204722:BR_RS04665
uniprot id: A0A0H3G7F3
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

204722:BR RS03055
gene id: 204722:BR_RS03055
uniprot id: Q8G1P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

204722:BR RS06180
gene id: 204722:BR_RS06180
uniprot id: A0A0H3G3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

204722:BR RS15355
gene id: 204722:BR_RS15355
uniprot id: A0A0H3G7U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

204722:BR RS06880
gene id: 204722:BR_RS06880
uniprot id: Q8FZJ3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

204722:BR RS14505
gene id: 204722:BR_RS14505
uniprot id: A0A0H3GG22
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS08835
gene id: 204722:BR_RS08835
uniprot id: A0A0H3G4P8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

204722:BR RS06820
gene id: 204722:BR_RS06820
uniprot id: P0A3U9
names: Subcellular Location Annotation
messages: Periplasm

204722:BR RS03200
gene id: 204722:BR_RS03200
uniprot id: Q8G1L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

204722:BR RS13050
gene id: 204722:BR_RS13050
uniprot id: A0A0H3G6P7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

204722:BR RS09165
gene id: 204722:BR_RS09165
uniprot id: A0A0H3G5N5
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

204722:BR RS03040
gene id: 204722:BR_RS03040
uniprot id: P63465
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

204722:BR RS10310
gene id: 204722:BR_RS10310
uniprot id: A0A0H3G9F3
names: Similarity
messages: Belongs to the glutamate synthase family.

204722:BR RS02070
gene id: 204722:BR_RS02070
uniprot id: A0A0H3G220
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS09945
gene id: 204722:BR_RS09945
uniprot id: Q8FXT6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

204722:BR RS05110
gene id: 204722:BR_RS05110
uniprot id: A0A0H3G3U8
names: Function
names: Similarity
messages: Belongs to the ribose 1,5-bisphosphokinase family.
messages: Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).

204722:BR RS09765
gene id: 204722:BR_RS09765
uniprot id: P66102
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

204722:BR RS05125
gene id: 204722:BR_RS05125
uniprot id: Q8G0I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

204722:BR RS06245
gene id: 204722:BR_RS06245
uniprot id: A0A0H3G3K9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

204722:BR RS02620
gene id: 204722:BR_RS02620
uniprot id: A0A0H3GAK4
names: Similarity
messages: Belongs to the peptidase S9A family.

204722:BR RS10370
gene id: 204722:BR_RS10370
uniprot id: Q9RPY1
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the TrbE/VirB4 family.
messages: Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.
messages: The VirB system could be required for the establishment of the replication niche in the host.
messages: Transcription of the operon is maximal in early exponential phase.

204722:BR RS00320
gene id: 204722:BR_RS00320
uniprot id: Q8G381
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

204722:BR RS08265
gene id: 204722:BR_RS08265
uniprot id: Q8FYR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

204722:BR RS07595
gene id: 204722:BR_RS07595
uniprot id: A0A0H3G445
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

204722:BR RS08305
gene id: 204722:BR_RS08305
uniprot id: Q8FYQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

204722:BR RS09050
gene id: 204722:BR_RS09050
uniprot id: A0A0H3G5L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

204722:BR RS13425
gene id: 204722:BR_RS13425
uniprot id: Q8FVU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

204722:BR RS11945
gene id: 204722:BR_RS11945
uniprot id: Q8FWN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm
messages: Probably part of an ABC transporter complex that could be involved in peptide import.
messages: The complex is composed of two ATP-binding proteins (BRA0404 and BRA0405), two transmembrane proteins (BRA0407 and BRA0408) and a solute-binding protein (BRA0409).

204722:BR RS13785
gene id: 204722:BR_RS13785
uniprot id: Q8FVN0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
messages: Cell inner membrane
messages: Induced by low oxygen tension and metal ion deficiency. Repressed by NiCl(2) excess.
messages: Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).

204722:BR RS13685
gene id: 204722:BR_RS13685
uniprot id: Q8FVP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

204722:BR RS04645
gene id: 204722:BR_RS04645
uniprot id: A0A0H3G3L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: Oligomer of 12 subunits arranged in the form of two hexameric ring.

204722:BR RS01545
gene id: 204722:BR_RS01545
uniprot id: Q8G2J0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

204722:BR RS15435
gene id: 204722:BR_RS15435
uniprot id: Q8FUS8
names: Caution
names: Function
names: Miscellaneous
messages: Lacks the conserved Asp residue in position 50 usually required for phosphorylation.
messages: Required for transcription of flagellar genes.
messages: There is no cognate histidine kinase partner identified so far for FtcR.

204722:BR RS05890
gene id: 204722:BR_RS05890
uniprot id: A0A0H3G3G7
names: Similarity
messages: Belongs to the FBPase class 2 family.

204722:BR RS14520
gene id: 204722:BR_RS14520
uniprot id: A0A0H3GC24
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS12490
gene id: 204722:BR_RS12490
uniprot id: A0A0H3GB39
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

204722:BR RS03415
gene id: 204722:BR_RS03415
uniprot id: A0A0H3G2N6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

204722:BR RS02845
gene id: 204722:BR_RS02845
uniprot id: A0A0H3G5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the O-antigen polymerase family.
messages: Membrane

204722:BR RS15340
gene id: 204722:BR_RS15340
uniprot id: A0A0H3G8G2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

204722:BR RS09940
gene id: 204722:BR_RS09940
uniprot id: A0A0H3GDW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Cytoplasm
messages: Homotetramer.

204722:BR RS12710
gene id: 204722:BR_RS12710
uniprot id: A0A0H3G787
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS03950
gene id: 204722:BR_RS03950
uniprot id: A0A0H3G2W2
names: Similarity
messages: Belongs to the aldose epimerase family.

204722:BR RS13760
gene id: 204722:BR_RS13760
uniprot id: A0A0H3GBN0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS14030
gene id: 204722:BR_RS14030
uniprot id: A0A0H3GBS6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS05500
gene id: 204722:BR_RS05500
uniprot id: A0A0H3G7V9
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

204722:BR RS15155
gene id: 204722:BR_RS15155
uniprot id: Q8FUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA1094), two transmembrane proteins (BRA1092 and BRA1093) and a solute-binding protein (BRA1090).

204722:BR RS01505
gene id: 204722:BR_RS01505
uniprot id: A0A0H3G5U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide deacetylase family.
messages: Cytoplasm
messages: Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts.

204722:BR RS05130
gene id: 204722:BR_RS05130
uniprot id: A0A0H3G7P0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

204722:BR RS03810
gene id: 204722:BR_RS03810
uniprot id: A0A0H3GB65
names: Subcellular Location Annotation
messages: Cytoplasm

204722:BR RS13870
gene id: 204722:BR_RS13870
uniprot id: A0A0H3GFR8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS15600
gene id: 204722:BR_RS15600
uniprot id: A0A0H3G8K4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS06680
gene id: 204722:BR_RS06680
uniprot id: A0A0H3GCG2
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

204722:BR RS04345
gene id: 204722:BR_RS04345
uniprot id: A0A0H3G3E4
names: Similarity
messages: Belongs to the HesB/IscA family.

204722:BR RS05760
gene id: 204722:BR_RS05760
uniprot id: Q8G069
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

204722:BR RS09980
gene id: 204722:BR_RS09980
uniprot id: Q8FXT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

204722:BR RS08785
gene id: 204722:BR_RS08785
uniprot id: A0A0H3GDF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

204722:BR RS09775
gene id: 204722:BR_RS09775
uniprot id: Q8FXX5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

204722:BR RS11140
gene id: 204722:BR_RS11140
uniprot id: A0A0H3G9U6
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

204722:BR RS05755
gene id: 204722:BR_RS05755
uniprot id: Q8G070
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

204722:BR RS03720
gene id: 204722:BR_RS03720
uniprot id: Q8G1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

204722:BR RS05300
gene id: 204722:BR_RS05300
uniprot id: Q8G0F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

204722:BR RS07920
gene id: 204722:BR_RS07920
uniprot id: A0A0H3GD05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

204722:BR RS11245
gene id: 204722:BR_RS11245
uniprot id: A0A0H3G6K0
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03855
gene id: 204722:BR_RS03855
uniprot id: A0A0H3G361
names: Similarity
messages: Belongs to the BolA/IbaG family.

204722:BR RS10035
gene id: 204722:BR_RS10035
uniprot id: A0A0H3G562
names: Similarity
messages: Belongs to the peptidase C40 family.

204722:BR RS09515
gene id: 204722:BR_RS09515
uniprot id: P67194
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

204722:BR RS08185
gene id: 204722:BR_RS08185
uniprot id: Q8FYT2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

204722:BR RS13235
gene id: 204722:BR_RS13235
uniprot id: A0A0H3G7G8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS08635
gene id: 204722:BR_RS08635
uniprot id: A0A0H3GDD4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

204722:BR RS08765
gene id: 204722:BR_RS08765
uniprot id: A0A0H3G9A0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

204722:BR RS05780
gene id: 204722:BR_RS05780
uniprot id: Q8G065
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

204722:BR RS09020
gene id: 204722:BR_RS09020
uniprot id: A0A0H3G8W1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

204722:BR RS11860
gene id: 204722:BR_RS11860
uniprot id: A0A0H3G6X3
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS09780
gene id: 204722:BR_RS09780
uniprot id: Q8FXX4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

204722:BR RS05625
gene id: 204722:BR_RS05625
uniprot id: Q8G090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

204722:BR RS09825
gene id: 204722:BR_RS09825
uniprot id: A0A0H3G530
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

204722:BR RS11625
gene id: 204722:BR_RS11625
uniprot id: A0A0H3GER8
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS11075
gene id: 204722:BR_RS11075
uniprot id: A0A0H3GEE8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

204722:BR RS04770
gene id: 204722:BR_RS04770
uniprot id: A0A0H3G7H4
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

204722:BR RS11435
gene id: 204722:BR_RS11435
uniprot id: A0A0H3G6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

204722:BR RS05900
gene id: 204722:BR_RS05900
uniprot id: A0A0H3G7Z1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

204722:BR RS04355
gene id: 204722:BR_RS04355
uniprot id: A0A0H3G6M0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

204722:BR RS15025
gene id: 204722:BR_RS15025
uniprot id: A0A0H3G8C3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

204722:BR RS05940
gene id: 204722:BR_RS05940
uniprot id: P65956
names: Similarity
messages: Belongs to the UPF0758 family.

204722:BR RS05385
gene id: 204722:BR_RS05385
uniprot id: P64049
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

204722:BR RS14635
gene id: 204722:BR_RS14635
uniprot id: A0A0H3GC47
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

204722:BR RS02190
gene id: 204722:BR_RS02190
uniprot id: A0A0H3GAB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

204722:BR RS01495
gene id: 204722:BR_RS01495
uniprot id: Q8G2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

204722:BR RS13000
gene id: 204722:BR_RS13000
uniprot id: A0A0H3G6N4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

204722:BR RS05085
gene id: 204722:BR_RS05085
uniprot id: Q8G0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: Periplasm

204722:BR RS14885
gene id: 204722:BR_RS14885
uniprot id: Q60CV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

204722:BR RS08180
gene id: 204722:BR_RS08180
uniprot id: A0A0H3G4E1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

204722:BR RS03860
gene id: 204722:BR_RS03860
uniprot id: Q8G183
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

204722:BR RS07655
gene id: 204722:BR_RS07655
uniprot id: Q8FZ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

204722:BR RS09885
gene id: 204722:BR_RS09885
uniprot id: A0A0H3G543
names: Similarity
messages: Belongs to the peptidase M29 family.

204722:BR RS11900
gene id: 204722:BR_RS11900
uniprot id: Q8FWP6
names: Function
names: Similarity
messages: Belongs to the leucine-binding protein family.
messages: Component of an amino-acid transport system.

204722:BR RS15165
gene id: 204722:BR_RS15165
uniprot id: Q8FUW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA1094), two transmembrane proteins (BRA1092 and BRA1093) and a solute-binding protein (BRA1090).

204722:BR RS03045
gene id: 204722:BR_RS03045
uniprot id: A0A0H3G2Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

204722:BR RS00810
gene id: 204722:BR_RS00810
uniprot id: P64306
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

204722:BR RS12470
gene id: 204722:BR_RS12470
uniprot id: A0A0H3G757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS09450
gene id: 204722:BR_RS09450
uniprot id: A0A0H3G501
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS14810
gene id: 204722:BR_RS14810
uniprot id: A0A0H3GC70
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS15095
gene id: 204722:BR_RS15095
uniprot id: A0A0H3GGB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system.

204722:BR RS12400
gene id: 204722:BR_RS12400
uniprot id: A0A0H3GAH6
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS03875
gene id: 204722:BR_RS03875
uniprot id: Q8G180
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

204722:BR RS08040
gene id: 204722:BR_RS08040
uniprot id: A0A0H3G8Y4
names: Subcellular Location Annotation
messages: Membrane

204722:BR RS05450
gene id: 204722:BR_RS05450
uniprot id: A0A0H3G7A2
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

204722:BR RS03995
gene id: 204722:BR_RS03995
uniprot id: Q8G156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

204722:BR RS00410
gene id: 204722:BR_RS00410
uniprot id: A0A0H3G9H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

204722:BR RS11700
gene id: 204722:BR_RS11700
uniprot id: Q8FWT4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

204722:BR RS09325
gene id: 204722:BR_RS09325
uniprot id: P63616
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

204722:BR RS14325
gene id: 204722:BR_RS14325
uniprot id: A0A0H3G7G2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

204722:BR RS13305
gene id: 204722:BR_RS13305
uniprot id: A0A0H3G7H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS01820
gene id: 204722:BR_RS01820
uniprot id: Q8G2D0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

204722:BR RS05650
gene id: 204722:BR_RS05650
uniprot id: Q8G086
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

204722:BR RS13835
gene id: 204722:BR_RS13835
uniprot id: A0A0H3GBP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

204722:BR RS10060
gene id: 204722:BR_RS10060
uniprot id: A0A0H3GDY2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

204722:BR RS05140
gene id: 204722:BR_RS05140
uniprot id: Q8G0I5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

204722:BR RS04040
gene id: 204722:BR_RS04040
uniprot id: P63934
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

204722:BR RS09270
gene id: 204722:BR_RS09270
uniprot id: P66141
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

204722:BR RS14955
gene id: 204722:BR_RS14955
uniprot id: Q8FV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

204722:BR RS01165
gene id: 204722:BR_RS01165
uniprot id: Q8G2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

204722:BR RS03805
gene id: 204722:BR_RS03805
uniprot id: Q8G195
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

204722:BR RS11515
gene id: 204722:BR_RS11515
uniprot id: Q8FWX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

204722:BR RS12090
gene id: 204722:BR_RS12090
uniprot id: A0A0H3G6Z6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

204722:BR RS04955
gene id: 204722:BR_RS04955
uniprot id: Q8G0L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

204722:BR RS06040
gene id: 204722:BR_RS06040
uniprot id: A0A0H3G3I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

204722:BR RS07860
gene id: 204722:BR_RS07860
uniprot id: A0A0H3GCZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

204722:BR RS02875
gene id: 204722:BR_RS02875
uniprot id: A0A0H3G6J6
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

204722:BR RS06015
gene id: 204722:BR_RS06015
uniprot id: Q8G018
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

204722:BR RS08865
gene id: 204722:BR_RS08865
uniprot id: A0A0H3G8U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

204722:BR RS13795
gene id: 204722:BR_RS13795
uniprot id: A0A0H3GB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane

204722:BR RS14785
gene id: 204722:BR_RS14785
uniprot id: A0A0H3GBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane.

204722:BR RS00990
gene id: 204722:BR_RS00990
uniprot id: Q8G2U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

204722:BR RS08725
gene id: 204722:BR_RS08725
uniprot id: Q8FYI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Cell inner membrane
messages: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
messages: Homohexamer. Forms a ring that surrounds DNA (By similarity).

204722:BR RS04965
gene id: 204722:BR_RS04965
uniprot id: Q8G0L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

204722:BR RS09475
gene id: 204722:BR_RS09475
uniprot id: Q8FY29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

204722:BR RS11645
gene id: 204722:BR_RS11645
uniprot id: A0A0H3GES3
names: Similarity
messages: Belongs to the peptidase S58 family.

204722:BR RS11920
gene id: 204722:BR_RS11920
uniprot id: Q8FWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).
messages: The complex is composed of two ATP-binding proteins (BRA0404 and BRA0405), two transmembrane proteins (BRA0407 and BRA0408) and a solute-binding protein (BRA0409).

204722:BR RS08390
gene id: 204722:BR_RS08390
uniprot id: A0A0H3G8P3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cell inner membrane
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

204722:BR RS00495
gene id: 204722:BR_RS00495
uniprot id: A0A0H3G4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm