194439:AYT24 RS09400
gene id: 194439:AYT24_RS09400
uniprot id: Q8KAS2
names: Similarity
messages: Belongs to the CIA30 family.

194439:AYT24 RS05700
gene id: 194439:AYT24_RS05700
uniprot id: Q8KCZ6
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

194439:AYT24 RS01725
gene id: 194439:AYT24_RS01725
uniprot id: Q8KFH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

194439:AYT24 RS00405
gene id: 194439:AYT24_RS00405
uniprot id: Q8KG86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

194439:AYT24 RS04655
gene id: 194439:AYT24_RS04655
uniprot id: Q8KDN4
names: Similarity
messages: Belongs to the universal stress protein A family.

194439:AYT24 RS01190
gene id: 194439:AYT24_RS01190
uniprot id: Q8KFT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

194439:AYT24 RS00545
gene id: 194439:AYT24_RS00545
uniprot id: Q8KG56
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

194439:AYT24 RS08080
gene id: 194439:AYT24_RS08080
uniprot id: Q8KBJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

194439:AYT24 RS06365
gene id: 194439:AYT24_RS06365
uniprot id: Q8KCK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS10575
gene id: 194439:AYT24_RS10575
uniprot id: Q8KBA9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

194439:AYT24 RS10225
gene id: 194439:AYT24_RS10225
uniprot id: Q8KAB0
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. ChlP subfamily.

194439:AYT24 RS02850
gene id: 194439:AYT24_RS02850
uniprot id: Q8KES3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the final reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
messages: Cytoplasm
messages: Homodimer.
messages: Slightly inhibited by N-acetyldopamine but not by N-acetylserotonin or melatonin.

194439:AYT24 RS09590
gene id: 194439:AYT24_RS09590
uniprot id: Q8KAN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

194439:AYT24 RS10035
gene id: 194439:AYT24_RS10035
uniprot id: Q8KAE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

194439:AYT24 RS08645
gene id: 194439:AYT24_RS08645
uniprot id: Q8KB76
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

194439:AYT24 RS00605
gene id: 194439:AYT24_RS00605
uniprot id: Q8KG42
names: Similarity
messages: Belongs to the acylphosphatase family.

194439:AYT24 RS00030
gene id: 194439:AYT24_RS00030
uniprot id: Q8KGG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

194439:AYT24 RS03855
gene id: 194439:AYT24_RS03855
uniprot id: Q8KE66
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

194439:AYT24 RS03370
gene id: 194439:AYT24_RS03370
uniprot id: Q8KEG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

194439:AYT24 RS02335
gene id: 194439:AYT24_RS02335
uniprot id: Q8KF48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

194439:AYT24 RS08055
gene id: 194439:AYT24_RS08055
uniprot id: Q8KBK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

194439:AYT24 RS06325
gene id: 194439:AYT24_RS06325
uniprot id: Q8KCL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

194439:AYT24 RS00110
gene id: 194439:AYT24_RS00110
uniprot id: Q8KGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

194439:AYT24 RS00495
gene id: 194439:AYT24_RS00495
uniprot id: Q8KG66
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS08125
gene id: 194439:AYT24_RS08125
uniprot id: Q8KBI9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

194439:AYT24 RS09625
gene id: 194439:AYT24_RS09625
uniprot id: Q8KAM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

194439:AYT24 RS05205
gene id: 194439:AYT24_RS05205
uniprot id: Q8KDA3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

194439:AYT24 RS01385
gene id: 194439:AYT24_RS01385
uniprot id: Q8KFP3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

194439:AYT24 RS08405
gene id: 194439:AYT24_RS08405
uniprot id: Q8KBD1
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

194439:AYT24 RS08165
gene id: 194439:AYT24_RS08165
uniprot id: Q8KBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

194439:AYT24 RS09065
gene id: 194439:AYT24_RS09065
uniprot id: Q8KAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

194439:AYT24 RS05815
gene id: 194439:AYT24_RS05815
uniprot id: Q8KCX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

194439:AYT24 RS04540
gene id: 194439:AYT24_RS04540
uniprot id: Q8KDR0
names: Similarity
messages: Belongs to the P(II) protein family.

194439:AYT24 RS08035
gene id: 194439:AYT24_RS08035
uniprot id: P59003
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

194439:AYT24 RS00585
gene id: 194439:AYT24_RS00585
uniprot id: Q8KG45
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

194439:AYT24 RS07200
gene id: 194439:AYT24_RS07200
uniprot id: Q8KC34
names: Similarity
messages: Belongs to the CarB family.

194439:AYT24 RS01500
gene id: 194439:AYT24_RS01500
uniprot id: Q9F721
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Cell inner membrane
messages: Component of the green S-bacteria bc complex, which consists of the Rieske protein and cytochrome b subunit but appears to lack a cytochrome c1-equivalent. This complex has a comparatively low redox potential (By similarity).
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

194439:AYT24 RS09680
gene id: 194439:AYT24_RS09680
uniprot id: Q8KAL5
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

194439:AYT24 RS08905
gene id: 194439:AYT24_RS08905
uniprot id: Q8KB28
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

194439:AYT24 RS07590
gene id: 194439:AYT24_RS07590
uniprot id: Q8KBV0
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

194439:AYT24 RS01270
gene id: 194439:AYT24_RS01270
uniprot id: Q8KFR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

194439:AYT24 RS07435
gene id: 194439:AYT24_RS07435
uniprot id: Q8KBY5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

194439:AYT24 RS08760
gene id: 194439:AYT24_RS08760
uniprot id: Q8KB54
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

194439:AYT24 RS00335
gene id: 194439:AYT24_RS00335
uniprot id: Q8KGA2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

194439:AYT24 RS03200
gene id: 194439:AYT24_RS03200
uniprot id: Q8KEK1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

194439:AYT24 RS03495
gene id: 194439:AYT24_RS03495
uniprot id: Q8KEE2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

194439:AYT24 RS00435
gene id: 194439:AYT24_RS00435
uniprot id: Q8KG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

194439:AYT24 RS00680
gene id: 194439:AYT24_RS00680
uniprot id: P59040
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

194439:AYT24 RS02840
gene id: 194439:AYT24_RS02840
uniprot id: Q8KES6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

194439:AYT24 RS06380
gene id: 194439:AYT24_RS06380
uniprot id: Q8KCK4
names: Similarity
messages: Belongs to the glutamine synthetase family.

194439:AYT24 RS03635
gene id: 194439:AYT24_RS03635
uniprot id: Q8KEB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

194439:AYT24 RS06120
gene id: 194439:AYT24_RS06120
uniprot id: Q8KCR3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS00660
gene id: 194439:AYT24_RS00660
uniprot id: Q8KG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

194439:AYT24 RS02310
gene id: 194439:AYT24_RS02310
uniprot id: Q8KF53
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

194439:AYT24 RS09220
gene id: 194439:AYT24_RS09220
uniprot id: Q8KAW0
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

194439:AYT24 RS02280
gene id: 194439:AYT24_RS02280
uniprot id: Q8KF60
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

194439:AYT24 RS03260
gene id: 194439:AYT24_RS03260
uniprot id: Q8KEI8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

194439:AYT24 RS05615
gene id: 194439:AYT24_RS05615
uniprot id: Q8KD16
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS08030
gene id: 194439:AYT24_RS08030
uniprot id: Q8KBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

194439:AYT24 RS09620
gene id: 194439:AYT24_RS09620
uniprot id: Q8KAM7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

194439:AYT24 RS09845
gene id: 194439:AYT24_RS09845
uniprot id: Q8KAI8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

194439:AYT24 RS04745
gene id: 194439:AYT24_RS04745
uniprot id: Q8KDL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

194439:AYT24 RS00265
gene id: 194439:AYT24_RS00265
uniprot id: Q8KGB5
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

194439:AYT24 RS07535
gene id: 194439:AYT24_RS07535
uniprot id: Q8KBW1
names: Similarity
messages: Belongs to the TrpC family.

194439:AYT24 RS09515
gene id: 194439:AYT24_RS09515
uniprot id: Q8KAP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS03365
gene id: 194439:AYT24_RS03365
uniprot id: Q8KEG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

194439:AYT24 RS00480
gene id: 194439:AYT24_RS00480
uniprot id: Q8KG70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

194439:AYT24 RS01450
gene id: 194439:AYT24_RS01450
uniprot id: Q8KFM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS01800
gene id: 194439:AYT24_RS01800
uniprot id: Q8KFF8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

194439:AYT24 RS03670
gene id: 194439:AYT24_RS03670
uniprot id: Q8KEA4
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

194439:AYT24 RS06655
gene id: 194439:AYT24_RS06655
uniprot id: Q8KCE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

194439:AYT24 RS01675
gene id: 194439:AYT24_RS01675
uniprot id: Q8KFI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

194439:AYT24 RS03590
gene id: 194439:AYT24_RS03590
uniprot id: Q8KEC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS06125
gene id: 194439:AYT24_RS06125
uniprot id: Q8KCR2
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS06455
gene id: 194439:AYT24_RS06455
uniprot id: Q93ST4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

194439:AYT24 RS05555
gene id: 194439:AYT24_RS05555
uniprot id: Q8KD27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS00860
gene id: 194439:AYT24_RS00860
uniprot id: Q8KFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

194439:AYT24 RS05110
gene id: 194439:AYT24_RS05110
uniprot id: Q8KDC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

194439:AYT24 RS06570
gene id: 194439:AYT24_RS06570
uniprot id: Q8KCH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

194439:AYT24 RS00080
gene id: 194439:AYT24_RS00080
uniprot id: Q8KGF2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

194439:AYT24 RS07055
gene id: 194439:AYT24_RS07055
uniprot id: Q8KC66
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS03625
gene id: 194439:AYT24_RS03625
uniprot id: Q8KEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS07690
gene id: 194439:AYT24_RS07690
uniprot id: Q8KBS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

194439:AYT24 RS01815
gene id: 194439:AYT24_RS01815
uniprot id: Q8KFF5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS01890
gene id: 194439:AYT24_RS01890
uniprot id: Q8KFD9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

194439:AYT24 RS08395
gene id: 194439:AYT24_RS08395
uniprot id: Q8KBD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

194439:AYT24 RS06810
gene id: 194439:AYT24_RS06810
uniprot id: Q8KCB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

194439:AYT24 RS06025
gene id: 194439:AYT24_RS06025
uniprot id: P59014
names: Function
names: Similarity
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: In the C-terminal section; belongs to the MoaB/Mog family.
messages: In the N-terminal section; belongs to the MoaC family.

194439:AYT24 RS09885
gene id: 194439:AYT24_RS09885
uniprot id: Q8KAI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

194439:AYT24 RS09550
gene id: 194439:AYT24_RS09550
uniprot id: Q8KAP1
names: Similarity
messages: Belongs to the fabD family.

194439:AYT24 RS07240
gene id: 194439:AYT24_RS07240
uniprot id: Q8KC24
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01295
gene id: 194439:AYT24_RS01295
uniprot id: Q8KFR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

194439:AYT24 RS02965
gene id: 194439:AYT24_RS02965
uniprot id: Q8KEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

194439:AYT24 RS06095
gene id: 194439:AYT24_RS06095
uniprot id: Q8KCR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

194439:AYT24 RS08680
gene id: 194439:AYT24_RS08680
uniprot id: Q8KB68
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

194439:AYT24 RS02020
gene id: 194439:AYT24_RS02020
uniprot id: Q8KFA9
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

194439:AYT24 RS05485
gene id: 194439:AYT24_RS05485
uniprot id: Q8KD46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

194439:AYT24 RS01520
gene id: 194439:AYT24_RS01520
uniprot id: Q8KFL9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

194439:AYT24 RS00325
gene id: 194439:AYT24_RS00325
uniprot id: Q8KGA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

194439:AYT24 RS08720
gene id: 194439:AYT24_RS08720
uniprot id: Q8KB62
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS00780
gene id: 194439:AYT24_RS00780
uniprot id: Q8KG16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

194439:AYT24 RS02550
gene id: 194439:AYT24_RS02550
uniprot id: Q8KEY9
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

194439:AYT24 RS01430
gene id: 194439:AYT24_RS01430
uniprot id: Q8KFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS03885
gene id: 194439:AYT24_RS03885
uniprot id: Q8KE60
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS00400
gene id: 194439:AYT24_RS00400
uniprot id: Q8KG87
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

194439:AYT24 RS08820
gene id: 194439:AYT24_RS08820
uniprot id: Q8KB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

194439:AYT24 RS02180
gene id: 194439:AYT24_RS02180
uniprot id: Q8KF79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

194439:AYT24 RS00005
gene id: 194439:AYT24_RS00005
uniprot id: Q8KGG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

194439:AYT24 RS00760
gene id: 194439:AYT24_RS00760
uniprot id: Q8KG20
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

194439:AYT24 RS06075
gene id: 194439:AYT24_RS06075
uniprot id: Q8KCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

194439:AYT24 RS09820
gene id: 194439:AYT24_RS09820
uniprot id: Q8KAJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

194439:AYT24 RS04820
gene id: 194439:AYT24_RS04820
uniprot id: Q8KDK0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

194439:AYT24 RS03045
gene id: 194439:AYT24_RS03045
uniprot id: Q8KEN5
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

194439:AYT24 RS03950
gene id: 194439:AYT24_RS03950
uniprot id: Q8KE43
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

194439:AYT24 RS05465
gene id: 194439:AYT24_RS05465
uniprot id: Q8KD49
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

194439:AYT24 RS08860
gene id: 194439:AYT24_RS08860
uniprot id: Q8KB36
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

194439:AYT24 RS01985
gene id: 194439:AYT24_RS01985
uniprot id: Q8KFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

194439:AYT24 RS06480
gene id: 194439:AYT24_RS06480
uniprot id: Q8KCJ0
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
messages: Does not seem to have a metal requirement for activity.
messages: Homooctamer.
messages: Stimulated by magnesium, inhibited by zinc.

194439:AYT24 RS06690
gene id: 194439:AYT24_RS06690
uniprot id: Q8KCE2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

194439:AYT24 RS09040
gene id: 194439:AYT24_RS09040
uniprot id: Q8KAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

194439:AYT24 RS01340
gene id: 194439:AYT24_RS01340
uniprot id: Q8KFQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

194439:AYT24 RS07220
gene id: 194439:AYT24_RS07220
uniprot id: Q8KC30
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

194439:AYT24 RS08795
gene id: 194439:AYT24_RS08795
uniprot id: Q8KB48
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

194439:AYT24 RS06855
gene id: 194439:AYT24_RS06855
uniprot id: Q8KCB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

194439:AYT24 RS05820
gene id: 194439:AYT24_RS05820
uniprot id: Q8KCX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

194439:AYT24 RS07175
gene id: 194439:AYT24_RS07175
uniprot id: Q8KC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

194439:AYT24 RS00465
gene id: 194439:AYT24_RS00465
uniprot id: Q8KG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

194439:AYT24 RS09385
gene id: 194439:AYT24_RS09385
uniprot id: Q8KAS5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 heme c group covalently per subunit.
messages: Dimer of one cytochrome and one flavoprotein.
messages: Monoheme cytochrome that function as the electron transport subunit of sulfide dehydrogenase.
messages: Periplasm

194439:AYT24 RS02820
gene id: 194439:AYT24_RS02820
uniprot id: Q8KET0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

194439:AYT24 RS06565
gene id: 194439:AYT24_RS06565
uniprot id: Q8KCH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

194439:AYT24 RS07855
gene id: 194439:AYT24_RS07855
uniprot id: Q8KBP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

194439:AYT24 RS00815
gene id: 194439:AYT24_RS00815
uniprot id: Q8KG09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

194439:AYT24 RS09810
gene id: 194439:AYT24_RS09810
uniprot id: Q8KAJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

194439:AYT24 RS01335
gene id: 194439:AYT24_RS01335
uniprot id: Q8KFQ4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

194439:AYT24 RS06720
gene id: 194439:AYT24_RS06720
uniprot id: Q8KCD5
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

194439:AYT24 RS07000
gene id: 194439:AYT24_RS07000
uniprot id: Q8KC76
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09905
gene id: 194439:AYT24_RS09905
uniprot id: Q8KAH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

194439:AYT24 RS07030
gene id: 194439:AYT24_RS07030
uniprot id: Q8KC71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

194439:AYT24 RS00215
gene id: 194439:AYT24_RS00215
uniprot id: Q8KGC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

194439:AYT24 RS09405
gene id: 194439:AYT24_RS09405
uniprot id: Q8KAS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

194439:AYT24 RS05280
gene id: 194439:AYT24_RS05280
uniprot id: Q8KD88
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

194439:AYT24 RS06345
gene id: 194439:AYT24_RS06345
uniprot id: Q8KCL3
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

194439:AYT24 RS10140
gene id: 194439:AYT24_RS10140
uniprot id: Q8KAC5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

194439:AYT24 RS01275
gene id: 194439:AYT24_RS01275
uniprot id: Q8KFR4
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS10375
gene id: 194439:AYT24_RS10375
uniprot id: Q8KA81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

194439:AYT24 RS02780
gene id: 194439:AYT24_RS02780
uniprot id: Q8KET9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

194439:AYT24 RS01605
gene id: 194439:AYT24_RS01605
uniprot id: Q8KFK3
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Involved in the biosynthesis of chlorobactene, a carotenoid with aromatic end group (PubMed:15292122). Catalyzes the introduction of two additional double bonds into the ionone ring of gamma-carotene to produce chlorobactene. The reaction includes an intramolecular methyl transfer from position C1 to position C2 of the ring (Probable).
messages: Mutant lacks chlorobactene and all its derivatives, and accumulates only gamma-carotene and its derivatives. The growth rate of the mutant shows no significant deviation from the wild-type growth rate at any light intensity.

194439:AYT24 RS03040
gene id: 194439:AYT24_RS03040
uniprot id: O68983
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Chlorosome
messages: Could play a direct role in the oxidation or reduction of the quenching species formed in the chlorosome.

194439:AYT24 RS07355
gene id: 194439:AYT24_RS07355
uniprot id: Q8KC00
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

194439:AYT24 RS04555
gene id: 194439:AYT24_RS04555
uniprot id: Q8KDQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

194439:AYT24 RS08455
gene id: 194439:AYT24_RS08455
uniprot id: Q8KBB8
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

194439:AYT24 RS07370
gene id: 194439:AYT24_RS07370
uniprot id: Q8KBZ7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

194439:AYT24 RS06105
gene id: 194439:AYT24_RS06105
uniprot id: Q8KCR6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

194439:AYT24 RS07925
gene id: 194439:AYT24_RS07925
uniprot id: Q8KBN0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

194439:AYT24 RS08220
gene id: 194439:AYT24_RS08220
uniprot id: Q8KBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

194439:AYT24 RS07515
gene id: 194439:AYT24_RS07515
uniprot id: Q8KBW5
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

194439:AYT24 RS08390
gene id: 194439:AYT24_RS08390
uniprot id: Q8KBD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

194439:AYT24 RS00010
gene id: 194439:AYT24_RS00010
uniprot id: Q8KGG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

194439:AYT24 RS08205
gene id: 194439:AYT24_RS08205
uniprot id: Q8KBH2
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

194439:AYT24 RS05420
gene id: 194439:AYT24_RS05420
uniprot id: Q8KD59
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

194439:AYT24 RS02945
gene id: 194439:AYT24_RS02945
uniprot id: Q8KEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

194439:AYT24 RS06110
gene id: 194439:AYT24_RS06110
uniprot id: Q8KCR5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

194439:AYT24 RS07835
gene id: 194439:AYT24_RS07835
uniprot id: Q8KBP9
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

194439:AYT24 RS05945
gene id: 194439:AYT24_RS05945
uniprot id: Q8KCU7
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

194439:AYT24 RS04455
gene id: 194439:AYT24_RS04455
uniprot id: P59077
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

194439:AYT24 RS01345
gene id: 194439:AYT24_RS01345
uniprot id: Q8KFQ2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

194439:AYT24 RS08065
gene id: 194439:AYT24_RS08065
uniprot id: Q8KBK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

194439:AYT24 RS06950
gene id: 194439:AYT24_RS06950
uniprot id: Q8KC87
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

194439:AYT24 RS06935
gene id: 194439:AYT24_RS06935
uniprot id: Q8KC90
names: Similarity
messages: Belongs to the P(II) protein family.

194439:AYT24 RS06275
gene id: 194439:AYT24_RS06275
uniprot id: Q8KCN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

194439:AYT24 RS02855
gene id: 194439:AYT24_RS02855
uniprot id: Q8KES2
names: Subcellular Location Annotation
messages: Cytoplasm

194439:AYT24 RS01850
gene id: 194439:AYT24_RS01850
uniprot id: Q8KFE7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

194439:AYT24 RS08250
gene id: 194439:AYT24_RS08250
uniprot id: Q8KBG2
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

194439:AYT24 RS01875
gene id: 194439:AYT24_RS01875
uniprot id: Q8KFE2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

194439:AYT24 RS08665
gene id: 194439:AYT24_RS08665
uniprot id: Q8KB71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS00015
gene id: 194439:AYT24_RS00015
uniprot id: Q8KGG5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

194439:AYT24 RS07050
gene id: 194439:AYT24_RS07050
uniprot id: Q8KC67
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS05135
gene id: 194439:AYT24_RS05135
uniprot id: Q8KDC0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

194439:AYT24 RS08180
gene id: 194439:AYT24_RS08180
uniprot id: Q8KBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

194439:AYT24 RS09635
gene id: 194439:AYT24_RS09635
uniprot id: Q8KAM4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

194439:AYT24 RS00235
gene id: 194439:AYT24_RS00235
uniprot id: Q8KGC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS01845
gene id: 194439:AYT24_RS01845
uniprot id: Q8KFE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
messages: Cell inner membrane
messages: Homodimer.
messages: Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.

194439:AYT24 RS08095
gene id: 194439:AYT24_RS08095
uniprot id: Q8KBJ5
names: Similarity
messages: Belongs to the HypE family.

194439:AYT24 RS01025
gene id: 194439:AYT24_RS01025
uniprot id: Q8KFX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

194439:AYT24 RS09960
gene id: 194439:AYT24_RS09960
uniprot id: Q8KAG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

194439:AYT24 RS07165
gene id: 194439:AYT24_RS07165
uniprot id: Q8KC42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

194439:AYT24 RS04440
gene id: 194439:AYT24_RS04440
uniprot id: Q8KDS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate (PubMed:25070637). Can also transaminate prephenate in the presence of aspartate (PubMed:25070637).
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS04320
gene id: 194439:AYT24_RS04320
uniprot id: Q8KDV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

194439:AYT24 RS05495
gene id: 194439:AYT24_RS05495
uniprot id: Q8KD44
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

194439:AYT24 RS08770
gene id: 194439:AYT24_RS08770
uniprot id: Q8KB52
names: Similarity
messages: Belongs to the arsA ATPase family.

194439:AYT24 RS09650
gene id: 194439:AYT24_RS09650
uniprot id: Q8KAM1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

194439:AYT24 RS04810
gene id: 194439:AYT24_RS04810
uniprot id: H2VFJ2
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

194439:AYT24 RS03915
gene id: 194439:AYT24_RS03915
uniprot id: Q8KE52
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

194439:AYT24 RS01390
gene id: 194439:AYT24_RS01390
uniprot id: Q8KFP2
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

194439:AYT24 RS07845
gene id: 194439:AYT24_RS07845
uniprot id: Q8KBP7
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

194439:AYT24 RS04860
gene id: 194439:AYT24_RS04860
uniprot id: Q8KDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

194439:AYT24 RS05605
gene id: 194439:AYT24_RS05605
uniprot id: Q8KD18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

194439:AYT24 RS10310
gene id: 194439:AYT24_RS10310
uniprot id: Q8KA94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

194439:AYT24 RS06355
gene id: 194439:AYT24_RS06355
uniprot id: Q8KCL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS02195
gene id: 194439:AYT24_RS02195
uniprot id: Q8KF76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

194439:AYT24 RS08195
gene id: 194439:AYT24_RS08195
uniprot id: Q8KBH4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

194439:AYT24 RS05685
gene id: 194439:AYT24_RS05685
uniprot id: Q8KCZ9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

194439:AYT24 RS09890
gene id: 194439:AYT24_RS09890
uniprot id: Q8KAI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

194439:AYT24 RS09315
gene id: 194439:AYT24_RS09315
uniprot id: Q46386
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BChl C/E-binding protein family.
messages: Component of the photosynthetic apparatus. The light harvesting B740 complex binds bacteriochlorophyll c.
messages: chlorosome envelope

194439:AYT24 RS04845
gene id: 194439:AYT24_RS04845
uniprot id: Q8KDJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

194439:AYT24 RS09745
gene id: 194439:AYT24_RS09745
uniprot id: Q9F716
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BchN/ChlN family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

194439:AYT24 RS09600
gene id: 194439:AYT24_RS09600
uniprot id: Q8KAN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Chlorophyllide reductase is composed of three subunits; BchX, BchY and BchZ. Forms a heterodimer of one BchY and one BchZ subunit.
messages: Converts chlorophylls (Chl) into bacteriochlorophylls (BChl) by reducing ring B of the tetrapyrrole.

194439:AYT24 RS07500
gene id: 194439:AYT24_RS07500
uniprot id: Q8KBW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

194439:AYT24 RS08670
gene id: 194439:AYT24_RS08670
uniprot id: Q8KB70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

194439:AYT24 RS04025
gene id: 194439:AYT24_RS04025
uniprot id: Q8KE25
names: Similarity
messages: Belongs to the HdrA family.

194439:AYT24 RS09570
gene id: 194439:AYT24_RS09570
uniprot id: Q8KAN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

194439:AYT24 RS10255
gene id: 194439:AYT24_RS10255
uniprot id: Q8KAA4
names: Similarity
messages: Belongs to the UPF0102 family.

194439:AYT24 RS02675
gene id: 194439:AYT24_RS02675
uniprot id: Q8KEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

194439:AYT24 RS06755
gene id: 194439:AYT24_RS06755
uniprot id: Q8KCC7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

194439:AYT24 RS07705
gene id: 194439:AYT24_RS07705
uniprot id: Q8KBS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

194439:AYT24 RS06845
gene id: 194439:AYT24_RS06845
uniprot id: Q8KCB2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

194439:AYT24 RS00730
gene id: 194439:AYT24_RS00730
uniprot id: Q8KG22
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

194439:AYT24 RS03115
gene id: 194439:AYT24_RS03115
uniprot id: Q8KEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

194439:AYT24 RS07735
gene id: 194439:AYT24_RS07735
uniprot id: Q8KBR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

194439:AYT24 RS07235
gene id: 194439:AYT24_RS07235
uniprot id: Q8KC25
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

194439:AYT24 RS03975
gene id: 194439:AYT24_RS03975
uniprot id: Q8KE37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

194439:AYT24 RS04345
gene id: 194439:AYT24_RS04345
uniprot id: Q8KDU9
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

194439:AYT24 RS02190
gene id: 194439:AYT24_RS02190
uniprot id: Q8KF78
names: Similarity
messages: Belongs to the NadC/ModD family.

194439:AYT24 RS05660
gene id: 194439:AYT24_RS05660
uniprot id: Q8KD05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

194439:AYT24 RS09615
gene id: 194439:AYT24_RS09615
uniprot id: Q8KAM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

194439:AYT24 RS06925
gene id: 194439:AYT24_RS06925
uniprot id: Q8KC92
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

194439:AYT24 RS05775
gene id: 194439:AYT24_RS05775
uniprot id: Q8KCY0
names: Similarity
messages: Belongs to the UPF0251 family.

194439:AYT24 RS02825
gene id: 194439:AYT24_RS02825
uniprot id: Q8KES9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

194439:AYT24 RS00175
gene id: 194439:AYT24_RS00175
uniprot id: Q8KGD3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS08060
gene id: 194439:AYT24_RS08060
uniprot id: Q8KBK3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

194439:AYT24 RS00170
gene id: 194439:AYT24_RS00170
uniprot id: Q8KGD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

194439:AYT24 RS07090
gene id: 194439:AYT24_RS07090
uniprot id: Q8KC58
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

194439:AYT24 RS00075
gene id: 194439:AYT24_RS00075
uniprot id: Q8KGF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS09935
gene id: 194439:AYT24_RS09935
uniprot id: Q8KAH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

194439:AYT24 RS06215
gene id: 194439:AYT24_RS06215
uniprot id: Q8KCP0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

194439:AYT24 RS10260
gene id: 194439:AYT24_RS10260
uniprot id: Q8KAA3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

194439:AYT24 RS03085
gene id: 194439:AYT24_RS03085
uniprot id: Q8KEM4
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

194439:AYT24 RS09805
gene id: 194439:AYT24_RS09805
uniprot id: Q8KAJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

194439:AYT24 RS09255
gene id: 194439:AYT24_RS09255
uniprot id: Q8KAV2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

194439:AYT24 RS06715
gene id: 194439:AYT24_RS06715
uniprot id: Q8KCD6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

194439:AYT24 RS00640
gene id: 194439:AYT24_RS00640
uniprot id: Q8KG34
names: Similarity
messages: Belongs to the P(II) protein family.

194439:AYT24 RS09190
gene id: 194439:AYT24_RS09190
uniprot id: Q8KAW6
names: Similarity
messages: Belongs to the threonine synthase family.

194439:AYT24 RS08985
gene id: 194439:AYT24_RS08985
uniprot id: Q8KB10
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

194439:AYT24 RS02900
gene id: 194439:AYT24_RS02900
uniprot id: Q8KER4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

194439:AYT24 RS07680
gene id: 194439:AYT24_RS07680
uniprot id: Q8KBS8
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS07950
gene id: 194439:AYT24_RS07950
uniprot id: Q8KBM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

194439:AYT24 RS00455
gene id: 194439:AYT24_RS00455
uniprot id: Q8KG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

194439:AYT24 RS05335
gene id: 194439:AYT24_RS05335
uniprot id: Q8KD77
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

194439:AYT24 RS09855
gene id: 194439:AYT24_RS09855
uniprot id: Q8KAI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

194439:AYT24 RS07260
gene id: 194439:AYT24_RS07260
uniprot id: Q8KC19
names: Similarity
messages: Belongs to the CutA family.

194439:AYT24 RS04575
gene id: 194439:AYT24_RS04575
uniprot id: Q8KDQ3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS03755
gene id: 194439:AYT24_RS03755
uniprot id: Q8KE87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

194439:AYT24 RS03955
gene id: 194439:AYT24_RS03955
uniprot id: Q8K5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

194439:AYT24 RS04590
gene id: 194439:AYT24_RS04590
uniprot id: Q8KDQ0
names: Subcellular Location Annotation
messages: chloroplast

194439:AYT24 RS10040
gene id: 194439:AYT24_RS10040
uniprot id: Q8KAE8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

194439:AYT24 RS07490
gene id: 194439:AYT24_RS07490
uniprot id: Q8KBX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the thioester dehydratase family.
messages: In the N-terminal section; belongs to the LpxC family.
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

194439:AYT24 RS03845
gene id: 194439:AYT24_RS03845
uniprot id: Q8KE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS09560
gene id: 194439:AYT24_RS09560
uniprot id: Q8KAN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

194439:AYT24 RS09425
gene id: 194439:AYT24_RS09425
uniprot id: Q8KAR7
names: Similarity
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

194439:AYT24 RS04490
gene id: 194439:AYT24_RS04490
uniprot id: Q8KDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

194439:AYT24 RS05270
gene id: 194439:AYT24_RS05270
uniprot id: Q8KD90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

194439:AYT24 RS09195
gene id: 194439:AYT24_RS09195
uniprot id: Q8KAW5
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

194439:AYT24 RS08270
gene id: 194439:AYT24_RS08270
uniprot id: Q8KBF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

194439:AYT24 RS04790
gene id: 194439:AYT24_RS04790
uniprot id: Q8KDK5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

194439:AYT24 RS01405
gene id: 194439:AYT24_RS01405
uniprot id: Q8KFN9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

194439:AYT24 RS06985
gene id: 194439:AYT24_RS06985
uniprot id: Q8KC80
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

194439:AYT24 RS08245
gene id: 194439:AYT24_RS08245
uniprot id: Q8KBG3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS06705
gene id: 194439:AYT24_RS06705
uniprot id: Q8KCD8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

194439:AYT24 RS06840
gene id: 194439:AYT24_RS06840
uniprot id: Q8KCB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

194439:AYT24 RS09795
gene id: 194439:AYT24_RS09795
uniprot id: Q8KAJ8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

194439:AYT24 RS08045
gene id: 194439:AYT24_RS08045
uniprot id: Q8KBK6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

194439:AYT24 RS07325
gene id: 194439:AYT24_RS07325
uniprot id: Q8KC06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

194439:AYT24 RS05995
gene id: 194439:AYT24_RS05995
uniprot id: Q8KCT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS09955
gene id: 194439:AYT24_RS09955
uniprot id: P59060
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

194439:AYT24 RS03005
gene id: 194439:AYT24_RS03005
uniprot id: Q8KEP3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

194439:AYT24 RS09735
gene id: 194439:AYT24_RS09735
uniprot id: Q9F714
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
messages: Homodimer. Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB.

194439:AYT24 RS07040
gene id: 194439:AYT24_RS07040
uniprot id: Q8KC69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

194439:AYT24 RS09535
gene id: 194439:AYT24_RS09535
uniprot id: Q8KAP4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

194439:AYT24 RS02170
gene id: 194439:AYT24_RS02170
uniprot id: Q8KF83
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS02685
gene id: 194439:AYT24_RS02685
uniprot id: Q8KEW3
names: Similarity
messages: Belongs to the GroES chaperonin family.

194439:AYT24 RS02660
gene id: 194439:AYT24_RS02660
uniprot id: Q8KEW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

194439:AYT24 RS07430
gene id: 194439:AYT24_RS07430
uniprot id: Q8KBY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

194439:AYT24 RS06555
gene id: 194439:AYT24_RS06555
uniprot id: Q8KCH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

194439:AYT24 RS04545
gene id: 194439:AYT24_RS04545
uniprot id: Q8KDQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS00610
gene id: 194439:AYT24_RS00610
uniprot id: Q8KG41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

194439:AYT24 RS07505
gene id: 194439:AYT24_RS07505
uniprot id: Q8KBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

194439:AYT24 RS01280
gene id: 194439:AYT24_RS01280
uniprot id: Q8KFR3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01215
gene id: 194439:AYT24_RS01215
uniprot id: Q8KFS6
names: Similarity
messages: Belongs to the YicC/YloC family.

194439:AYT24 RS00180
gene id: 194439:AYT24_RS00180
uniprot id: Q8KGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

194439:AYT24 RS02640
gene id: 194439:AYT24_RS02640
uniprot id: Q8KEX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

194439:AYT24 RS09915
gene id: 194439:AYT24_RS09915
uniprot id: Q8KAH6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

194439:AYT24 RS07530
gene id: 194439:AYT24_RS07530
uniprot id: Q8KBW2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS01760
gene id: 194439:AYT24_RS01760
uniprot id: Q8KFG6
names: Similarity
messages: Belongs to the RecJ family.

194439:AYT24 RS03610
gene id: 194439:AYT24_RS03610
uniprot id: Q8KEB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

194439:AYT24 RS07775
gene id: 194439:AYT24_RS07775
uniprot id: Q8KBR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS08790
gene id: 194439:AYT24_RS08790
uniprot id: Q46366
names: Function
names: Similarity
messages: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
messages: Belongs to the arsA ATPase family.

194439:AYT24 RS09785
gene id: 194439:AYT24_RS09785
uniprot id: Q8KAK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

194439:AYT24 RS00940
gene id: 194439:AYT24_RS00940
uniprot id: Q8KFY5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS01710
gene id: 194439:AYT24_RS01710
uniprot id: Q8KFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

194439:AYT24 RS06580
gene id: 194439:AYT24_RS06580
uniprot id: Q8KCG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

194439:AYT24 RS04315
gene id: 194439:AYT24_RS04315
uniprot id: Q8KDV5
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

194439:AYT24 RS10130
gene id: 194439:AYT24_RS10130
uniprot id: Q8KAC7
names: Similarity
messages: Belongs to the peptidase S66 family.

194439:AYT24 RS02515
gene id: 194439:AYT24_RS02515
uniprot id: Q8KEZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

194439:AYT24 RS04565
gene id: 194439:AYT24_RS04565
uniprot id: Q8KDQ5
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

194439:AYT24 RS00975
gene id: 194439:AYT24_RS00975
uniprot id: Q8KFX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

194439:AYT24 RS00835
gene id: 194439:AYT24_RS00835
uniprot id: Q8KG04
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

194439:AYT24 RS05275
gene id: 194439:AYT24_RS05275
uniprot id: Q8KD89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

194439:AYT24 RS01680
gene id: 194439:AYT24_RS01680
uniprot id: Q8KFI7
names: Similarity
messages: Belongs to the UPF0047 family.

194439:AYT24 RS03725
gene id: 194439:AYT24_RS03725
uniprot id: Q8KE92
names: Similarity
messages: Belongs to the universal stress protein A family.

194439:AYT24 RS04240
gene id: 194439:AYT24_RS04240
uniprot id: Q8KDX1
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS05405
gene id: 194439:AYT24_RS05405
uniprot id: Q8KD62
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

194439:AYT24 RS02540
gene id: 194439:AYT24_RS02540
uniprot id: Q8KEZ1
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS05285
gene id: 194439:AYT24_RS05285
uniprot id: Q8KD87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

194439:AYT24 RS00420
gene id: 194439:AYT24_RS00420
uniprot id: Q8KG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

194439:AYT24 RS06260
gene id: 194439:AYT24_RS06260
uniprot id: Q8KCN2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

194439:AYT24 RS05870
gene id: 194439:AYT24_RS05870
uniprot id: Q93SW0
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

194439:AYT24 RS09910
gene id: 194439:AYT24_RS09910
uniprot id: Q8KAH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

194439:AYT24 RS01195
gene id: 194439:AYT24_RS01195
uniprot id: Q8KFT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

194439:AYT24 RS08900
gene id: 194439:AYT24_RS08900
uniprot id: Q8KB29
names: Similarity
messages: Belongs to the CFA/CMAS family.

194439:AYT24 RS09075
gene id: 194439:AYT24_RS09075
uniprot id: Q8KAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

194439:AYT24 RS05625
gene id: 194439:AYT24_RS05625
uniprot id: Q8KD14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

194439:AYT24 RS01755
gene id: 194439:AYT24_RS01755
uniprot id: Q8KFG8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

194439:AYT24 RS09840
gene id: 194439:AYT24_RS09840
uniprot id: Q8KAI9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

194439:AYT24 RS00370
gene id: 194439:AYT24_RS00370
uniprot id: Q8KG93
names: Function
names: PTM
messages: Binds 1 heme c group covalently per subunit.
messages: This basic c-type monoheme cytochrome has been found exclusively in the green photosynthetic bacteria, although its role in bacterial photosynthesis is not established. It has an unusually low redox potential compared with mitochondrial cytochrome c. It is reactive with cytochrome c oxidases but not with reductases.

194439:AYT24 RS06210
gene id: 194439:AYT24_RS06210
uniprot id: Q8KCP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

194439:AYT24 RS00755
gene id: 194439:AYT24_RS00755
uniprot id: Q8KG21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

194439:AYT24 RS04805
gene id: 194439:AYT24_RS04805
uniprot id: O68986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsmB/CsmF family.
messages: chlorosome envelope

194439:AYT24 RS06820
gene id: 194439:AYT24_RS06820
uniprot id: P80039
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homotetramer; arranged as a dimer of dimers.

194439:AYT24 RS09740
gene id: 194439:AYT24_RS09740
uniprot id: Q9F715
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

194439:AYT24 RS06745
gene id: 194439:AYT24_RS06745
uniprot id: Q8KCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

194439:AYT24 RS04290
gene id: 194439:AYT24_RS04290
uniprot id: Q8KDW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

194439:AYT24 RS04515
gene id: 194439:AYT24_RS04515
uniprot id: Q8KDR5
names: Similarity
messages: Belongs to the arsA ATPase family.

194439:AYT24 RS05260
gene id: 194439:AYT24_RS05260
uniprot id: Q8KD92
names: Similarity
messages: Belongs to the Nth/MutY family.

194439:AYT24 RS00470
gene id: 194439:AYT24_RS00470
uniprot id: Q8KG73
names: Similarity
messages: Belongs to the aspartokinase family.

194439:AYT24 RS08040
gene id: 194439:AYT24_RS08040
uniprot id: Q8KBK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

194439:AYT24 RS08375
gene id: 194439:AYT24_RS08375
uniprot id: Q8KBD7
names: Similarity
messages: Belongs to the ParB family.

194439:AYT24 RS04125
gene id: 194439:AYT24_RS04125
uniprot id: Q8KDZ9
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

194439:AYT24 RS07110
gene id: 194439:AYT24_RS07110
uniprot id: Q8KC53
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

194439:AYT24 RS02390
gene id: 194439:AYT24_RS02390
uniprot id: Q8KF33
names: Similarity
messages: Belongs to the P(II) protein family.

194439:AYT24 RS08240
gene id: 194439:AYT24_RS08240
uniprot id: Q8KBG4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

194439:AYT24 RS09655
gene id: 194439:AYT24_RS09655
uniprot id: Q8KAM0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

194439:AYT24 RS01055
gene id: 194439:AYT24_RS01055
uniprot id: Q8KFW4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

194439:AYT24 RS09800
gene id: 194439:AYT24_RS09800
uniprot id: P59129
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

194439:AYT24 RS08105
gene id: 194439:AYT24_RS08105
uniprot id: Q8KBJ3
names: Similarity
messages: Belongs to the HypD family.

194439:AYT24 RS04150
gene id: 194439:AYT24_RS04150
uniprot id: Q8KDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

194439:AYT24 RS09760
gene id: 194439:AYT24_RS09760
uniprot id: Q8KAK5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

194439:AYT24 RS02490
gene id: 194439:AYT24_RS02490
uniprot id: Q8KF03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

194439:AYT24 RS02400
gene id: 194439:AYT24_RS02400
uniprot id: Q8KF30
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

194439:AYT24 RS06940
gene id: 194439:AYT24_RS06940
uniprot id: Q8KC89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

194439:AYT24 RS04005
gene id: 194439:AYT24_RS04005
uniprot id: Q8KE30
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

194439:AYT24 RS00275
gene id: 194439:AYT24_RS00275
uniprot id: Q8KGB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

194439:AYT24 RS05865
gene id: 194439:AYT24_RS05865
uniprot id: H2VFJ9
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

194439:AYT24 RS05610
gene id: 194439:AYT24_RS05610
uniprot id: Q8KD17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

194439:AYT24 RS06665
gene id: 194439:AYT24_RS06665
uniprot id: Q8KCE7
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS06735
gene id: 194439:AYT24_RS06735
uniprot id: Q8KCD1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS06595
gene id: 194439:AYT24_RS06595
uniprot id: Q8KCG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

194439:AYT24 RS09180
gene id: 194439:AYT24_RS09180
uniprot id: Q8KAW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12) (By similarity).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

194439:AYT24 RS08120
gene id: 194439:AYT24_RS08120
uniprot id: Q8KBJ0
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

194439:AYT24 RS02420
gene id: 194439:AYT24_RS02420
uniprot id: Q8KF21
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

194439:AYT24 RS09940
gene id: 194439:AYT24_RS09940
uniprot id: Q8KAH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

194439:AYT24 RS08865
gene id: 194439:AYT24_RS08865
uniprot id: Q8KB35
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

194439:AYT24 RS03595
gene id: 194439:AYT24_RS03595
uniprot id: Q8KEC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS03025
gene id: 194439:AYT24_RS03025
uniprot id: Q8KEN8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

194439:AYT24 RS09830
gene id: 194439:AYT24_RS09830
uniprot id: Q8KAJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

194439:AYT24 RS01540
gene id: 194439:AYT24_RS01540
uniprot id: Q8KFL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

194439:AYT24 RS10095
gene id: 194439:AYT24_RS10095
uniprot id: Q8KAD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

194439:AYT24 RS03880
gene id: 194439:AYT24_RS03880
uniprot id: Q8KE61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

194439:AYT24 RS09995
gene id: 194439:AYT24_RS09995
uniprot id: Q8KAF6
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS07445
gene id: 194439:AYT24_RS07445
uniprot id: Q8KBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

194439:AYT24 RS05400
gene id: 194439:AYT24_RS05400
uniprot id: Q8KD63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

194439:AYT24 RS01220
gene id: 194439:AYT24_RS01220
uniprot id: Q8KFS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

194439:AYT24 RS01245
gene id: 194439:AYT24_RS01245
uniprot id: Q8KFS0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

194439:AYT24 RS03720
gene id: 194439:AYT24_RS03720
uniprot id: Q8KE93
names: Similarity
messages: Belongs to the band 7/mec-2 family.

194439:AYT24 RS07585
gene id: 194439:AYT24_RS07585
uniprot id: Q8KBV1
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01180
gene id: 194439:AYT24_RS01180
uniprot id: Q8KFT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

194439:AYT24 RS08355
gene id: 194439:AYT24_RS08355
uniprot id: Q8KBE1
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

194439:AYT24 RS04985
gene id: 194439:AYT24_RS04985
uniprot id: Q8KDG1
names: Similarity
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

194439:AYT24 RS04875
gene id: 194439:AYT24_RS04875
uniprot id: Q8KDI7
names: Subcellular Location Annotation
messages: chloroplast

194439:AYT24 RS08300
gene id: 194439:AYT24_RS08300
uniprot id: Q8KBF3
names: Similarity
messages: Belongs to the citrate synthase family.

194439:AYT24 RS01060
gene id: 194439:AYT24_RS01060
uniprot id: Q8KFW3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS09185
gene id: 194439:AYT24_RS09185
uniprot id: Q8KAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

194439:AYT24 RS09085
gene id: 194439:AYT24_RS09085
uniprot id: Q8KAY6
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

194439:AYT24 RS01355
gene id: 194439:AYT24_RS01355
uniprot id: Q8KFP9
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09430
gene id: 194439:AYT24_RS09430
uniprot id: Q8KAR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

194439:AYT24 RS01790
gene id: 194439:AYT24_RS01790
uniprot id: P59316
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

194439:AYT24 RS05115
gene id: 194439:AYT24_RS05115
uniprot id: Q8KDC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

194439:AYT24 RS10200
gene id: 194439:AYT24_RS10200
uniprot id: Q8K5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

194439:AYT24 RS08050
gene id: 194439:AYT24_RS08050
uniprot id: Q8KBK5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

194439:AYT24 RS08800
gene id: 194439:AYT24_RS08800
uniprot id: Q8KB47
names: Subunit
messages: Homotetramer.

194439:AYT24 RS08130
gene id: 194439:AYT24_RS08130
uniprot id: Q8KBI8
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

194439:AYT24 RS07250
gene id: 194439:AYT24_RS07250
uniprot id: Q8KC21
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

194439:AYT24 RS00100
gene id: 194439:AYT24_RS00100
uniprot id: Q8KGE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).

194439:AYT24 RS09105
gene id: 194439:AYT24_RS09105
uniprot id: Q8KAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

194439:AYT24 RS06200
gene id: 194439:AYT24_RS06200
uniprot id: Q8KCP5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

194439:AYT24 RS09160
gene id: 194439:AYT24_RS09160
uniprot id: Q8KAX3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

194439:AYT24 RS03120
gene id: 194439:AYT24_RS03120
uniprot id: Q8KEL8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

194439:AYT24 RS05035
gene id: 194439:AYT24_RS05035
uniprot id: Q8KDF0
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09170
gene id: 194439:AYT24_RS09170
uniprot id: Q8KAX1
names: Similarity
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

194439:AYT24 RS07115
gene id: 194439:AYT24_RS07115
uniprot id: Q8KC52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

194439:AYT24 RS09835
gene id: 194439:AYT24_RS09835
uniprot id: Q8KAJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

194439:AYT24 RS08460
gene id: 194439:AYT24_RS08460
uniprot id: Q8KBB6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS01580
gene id: 194439:AYT24_RS01580
uniprot id: Q8KFK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

194439:AYT24 RS04505
gene id: 194439:AYT24_RS04505
uniprot id: Q8KDR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

194439:AYT24 RS06285
gene id: 194439:AYT24_RS06285
uniprot id: Q8KCM7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS02320
gene id: 194439:AYT24_RS02320
uniprot id: Q8KF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

194439:AYT24 RS00930
gene id: 194439:AYT24_RS00930
uniprot id: Q8KFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS00635
gene id: 194439:AYT24_RS00635
uniprot id: Q8KG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS07785
gene id: 194439:AYT24_RS07785
uniprot id: Q8KBQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS07700
gene id: 194439:AYT24_RS07700
uniprot id: Q8KBS4
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

194439:AYT24 RS09825
gene id: 194439:AYT24_RS09825
uniprot id: Q8KAJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

194439:AYT24 RS04970
gene id: 194439:AYT24_RS04970
uniprot id: Q8KDG5
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

194439:AYT24 RS08525
gene id: 194439:AYT24_RS08525
uniprot id: Q8KBA3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

194439:AYT24 RS04950
gene id: 194439:AYT24_RS04950
uniprot id: Q8KDH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

194439:AYT24 RS04350
gene id: 194439:AYT24_RS04350
uniprot id: Q8KDU8
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

194439:AYT24 RS08750
gene id: 194439:AYT24_RS08750
uniprot id: Q8KB56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

194439:AYT24 RS10280
gene id: 194439:AYT24_RS10280
uniprot id: Q8KAA1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

194439:AYT24 RS01945
gene id: 194439:AYT24_RS01945
uniprot id: Q8KFC8
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

194439:AYT24 RS06465
gene id: 194439:AYT24_RS06465
uniprot id: Q8KCJ3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

194439:AYT24 RS00800
gene id: 194439:AYT24_RS00800
uniprot id: Q8KG12
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

194439:AYT24 RS07015
gene id: 194439:AYT24_RS07015
uniprot id: Q8KC74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

194439:AYT24 RS05540
gene id: 194439:AYT24_RS05540
uniprot id: Q8KD34
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

194439:AYT24 RS05350
gene id: 194439:AYT24_RS05350
uniprot id: Q8KD74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

194439:AYT24 RS02205
gene id: 194439:AYT24_RS02205
uniprot id: Q8KF74
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

194439:AYT24 RS03415
gene id: 194439:AYT24_RS03415
uniprot id: Q8KEF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

194439:AYT24 RS06975
gene id: 194439:AYT24_RS06975
uniprot id: Q8KC82
names: Similarity
messages: Belongs to the ModE family.

194439:AYT24 RS10025
gene id: 194439:AYT24_RS10025
uniprot id: P59599
names: Similarity
messages: Belongs to the acetyltransferase family.

194439:AYT24 RS01515
gene id: 194439:AYT24_RS01515
uniprot id: Q8KFM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

194439:AYT24 RS00770
gene id: 194439:AYT24_RS00770
uniprot id: Q8KG18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

194439:AYT24 RS08575
gene id: 194439:AYT24_RS08575
uniprot id: Q8KB93
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

194439:AYT24 RS07550
gene id: 194439:AYT24_RS07550
uniprot id: Q8KBV8
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

194439:AYT24 RS05960
gene id: 194439:AYT24_RS05960
uniprot id: Q8KCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

194439:AYT24 RS05545
gene id: 194439:AYT24_RS05545
uniprot id: Q8KD33
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS00145
gene id: 194439:AYT24_RS00145
uniprot id: Q8KGD9
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

194439:AYT24 RS01205
gene id: 194439:AYT24_RS01205
uniprot id: Q8KFS8
names: Similarity
messages: Belongs to the ribF family.

194439:AYT24 RS00375
gene id: 194439:AYT24_RS00375
uniprot id: Q8KG92
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01775
gene id: 194439:AYT24_RS01775
uniprot id: Q8KFG3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS02995
gene id: 194439:AYT24_RS02995
uniprot id: Q8KEP5
names: Subunit
messages: Component of the P840 reaction center.

194439:AYT24 RS07400
gene id: 194439:AYT24_RS07400
uniprot id: O07091
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 heme group per subunit.
messages: Cell inner membrane
messages: Monoheme cytochrome which is the immediate electron donor to P840 of the photosynthetic reaction center complex.
messages: Monomer (PubMed:20156447). Component of the photosynthetic reaction center composed of protein subunits PscA, PscC, PscB and PscD. The reaction center interacts with FmoA (which forms the Fenna-Matthews-Olson (FMO) complex). The reaction center/FmoA complex has two PscA subunits, one PscB and one PscD subunit, probably two FmoA complexes and at least one PscC subunit (PubMed:10398586).

194439:AYT24 RS05060
gene id: 194439:AYT24_RS05060
uniprot id: P59611
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

194439:AYT24 RS00795
gene id: 194439:AYT24_RS00795
uniprot id: Q8KG13
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

194439:AYT24 RS01495
gene id: 194439:AYT24_RS01495
uniprot id: Q9F722
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cell inner membrane
messages: Component of the green S-bacteria bc-complex which consists of the Rieske protein and cytochrome b subunit and which appears to lack a cytochrome c1-equivalent. This complex has a comparatively low redox potential.
messages: The Rieske protein is a high potential 2Fe-2S protein.

194439:AYT24 RS02370
gene id: 194439:AYT24_RS02370
uniprot id: Q8KF38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

194439:AYT24 RS07420
gene id: 194439:AYT24_RS07420
uniprot id: Q8KBY8
names: Similarity
messages: Belongs to the peptidase S49 family.

194439:AYT24 RS10120
gene id: 194439:AYT24_RS10120
uniprot id: Q8KAC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

194439:AYT24 RS00210
gene id: 194439:AYT24_RS00210
uniprot id: Q8KGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

194439:AYT24 RS09930
gene id: 194439:AYT24_RS09930
uniprot id: Q8KAH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

194439:AYT24 RS09610
gene id: 194439:AYT24_RS09610
uniprot id: Q8KAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

194439:AYT24 RS05695
gene id: 194439:AYT24_RS05695
uniprot id: Q8KCZ7
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

194439:AYT24 RS05825
gene id: 194439:AYT24_RS05825
uniprot id: Q8KCW9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

194439:AYT24 RS10125
gene id: 194439:AYT24_RS10125
uniprot id: Q8KAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

194439:AYT24 RS07275
gene id: 194439:AYT24_RS07275
uniprot id: H2VFJ6
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS06955
gene id: 194439:AYT24_RS06955
uniprot id: Q8KC86
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

194439:AYT24 RS01825
gene id: 194439:AYT24_RS01825
uniprot id: Q8KFF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS06165
gene id: 194439:AYT24_RS06165
uniprot id: Q8KCQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

194439:AYT24 RS07005
gene id: 194439:AYT24_RS07005
uniprot id: Q8KC75
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

194439:AYT24 RS08345
gene id: 194439:AYT24_RS08345
uniprot id: Q8KBE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

194439:AYT24 RS08295
gene id: 194439:AYT24_RS08295
uniprot id: Q8KBF4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

194439:AYT24 RS05070
gene id: 194439:AYT24_RS05070
uniprot id: Q8KDE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks the conserved threonine and leucine residues in positions 66 and 276, respectively, which are part of the carbamoylphosphate and ornithine binding sites; they are replaced by a leucine and a methionine residue, respectively.
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

194439:AYT24 RS00510
gene id: 194439:AYT24_RS00510
uniprot id: Q8KG63
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

194439:AYT24 RS05030
gene id: 194439:AYT24_RS05030
uniprot id: P58993
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Monomer.
messages: Serves as an electron acceptor for pyruvate ferredoxin oxidoreductase (PFOR).

194439:AYT24 RS06960
gene id: 194439:AYT24_RS06960
uniprot id: Q8KC85
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Binds 3 [4Fe-4S] clusters per monomer. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. The two others probably act as substrate.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
messages: Monomer.

194439:AYT24 RS01210
gene id: 194439:AYT24_RS01210
uniprot id: Q8KFS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

194439:AYT24 RS06640
gene id: 194439:AYT24_RS06640
uniprot id: Q8KCF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS05080
gene id: 194439:AYT24_RS05080
uniprot id: Q8KDE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

194439:AYT24 RS07330
gene id: 194439:AYT24_RS07330
uniprot id: Q8KC05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

194439:AYT24 RS05325
gene id: 194439:AYT24_RS05325
uniprot id: Q8KD79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

194439:AYT24 RS02890
gene id: 194439:AYT24_RS02890
uniprot id: Q8KER6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

194439:AYT24 RS00065
gene id: 194439:AYT24_RS00065
uniprot id: Q8KGF5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

194439:AYT24 RS01965
gene id: 194439:AYT24_RS01965
uniprot id: Q8KFC3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

194439:AYT24 RS06040
gene id: 194439:AYT24_RS06040
uniprot id: P59038
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

194439:AYT24 RS01690
gene id: 194439:AYT24_RS01690
uniprot id: Q8KFI4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

194439:AYT24 RS03300
gene id: 194439:AYT24_RS03300
uniprot id: Q8KEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

194439:AYT24 RS06295
gene id: 194439:AYT24_RS06295
uniprot id: Q8KCM3
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09790
gene id: 194439:AYT24_RS09790
uniprot id: Q8KAJ9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

194439:AYT24 RS06180
gene id: 194439:AYT24_RS06180
uniprot id: Q8KCP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS05440
gene id: 194439:AYT24_RS05440
uniprot id: Q8KD55
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01550
gene id: 194439:AYT24_RS01550
uniprot id: Q8KFL3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

194439:AYT24 RS06265
gene id: 194439:AYT24_RS06265
uniprot id: O68988
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Chlorosome
messages: Could play a direct role in the oxidation or reduction of the quenching species formed in the chlorosome.

194439:AYT24 RS09605
gene id: 194439:AYT24_RS09605
uniprot id: Q8KAN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS04480
gene id: 194439:AYT24_RS04480
uniprot id: Q8KDS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

194439:AYT24 RS06460
gene id: 194439:AYT24_RS06460
uniprot id: Q8KCJ4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

194439:AYT24 RS00185
gene id: 194439:AYT24_RS00185
uniprot id: Q8KGD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

194439:AYT24 RS08745
gene id: 194439:AYT24_RS08745
uniprot id: Q8KB57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

194439:AYT24 RS01570
gene id: 194439:AYT24_RS01570
uniprot id: Q8KFL0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

194439:AYT24 RS07450
gene id: 194439:AYT24_RS07450
uniprot id: Q8KBY0
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

194439:AYT24 RS06815
gene id: 194439:AYT24_RS06815
uniprot id: Q8KCB7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

194439:AYT24 RS00150
gene id: 194439:AYT24_RS00150
uniprot id: Q8KGD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS08910
gene id: 194439:AYT24_RS08910
uniprot id: Q8KB27
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

194439:AYT24 RS00595
gene id: 194439:AYT24_RS00595
uniprot id: Q8KG43
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

194439:AYT24 RS01490
gene id: 194439:AYT24_RS01490
uniprot id: Q9F723
names: Similarity
messages: Belongs to the CrtC hydratase family.

194439:AYT24 RS05955
gene id: 194439:AYT24_RS05955
uniprot id: Q8KCU5
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

194439:AYT24 RS05010
gene id: 194439:AYT24_RS05010
uniprot id: Q8KDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

194439:AYT24 RS08730
gene id: 194439:AYT24_RS08730
uniprot id: O52393
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

194439:AYT24 RS02560
gene id: 194439:AYT24_RS02560
uniprot id: Q8KEY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

194439:AYT24 RS02555
gene id: 194439:AYT24_RS02555
uniprot id: Q8KEY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

194439:AYT24 RS09925
gene id: 194439:AYT24_RS09925
uniprot id: Q8KAH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

194439:AYT24 RS02655
gene id: 194439:AYT24_RS02655
uniprot id: Q8KEW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS06650
gene id: 194439:AYT24_RS06650
uniprot id: Q8KCF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

194439:AYT24 RS00590
gene id: 194439:AYT24_RS00590
uniprot id: Q8KG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

194439:AYT24 RS01640
gene id: 194439:AYT24_RS01640
uniprot id: Q8KFJ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

194439:AYT24 RS02295
gene id: 194439:AYT24_RS02295
uniprot id: Q8KF56
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

194439:AYT24 RS09205
gene id: 194439:AYT24_RS09205
uniprot id: Q8KAW3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

194439:AYT24 RS01265
gene id: 194439:AYT24_RS01265
uniprot id: Q8KFR6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

194439:AYT24 RS09175
gene id: 194439:AYT24_RS09175
uniprot id: Q8KAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

194439:AYT24 RS04140
gene id: 194439:AYT24_RS04140
uniprot id: Q8KDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS02530
gene id: 194439:AYT24_RS02530
uniprot id: Q8KEZ4
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS07160
gene id: 194439:AYT24_RS07160
uniprot id: Q8KC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

194439:AYT24 RS01665
gene id: 194439:AYT24_RS01665
uniprot id: Q8KFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

194439:AYT24 RS06790
gene id: 194439:AYT24_RS06790
uniprot id: Q8KCC2
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS10060
gene id: 194439:AYT24_RS10060
uniprot id: Q8KAE2
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09210
gene id: 194439:AYT24_RS09210
uniprot id: Q8KAW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS04520
gene id: 194439:AYT24_RS04520
uniprot id: Q8KDR4
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

194439:AYT24 RS04895
gene id: 194439:AYT24_RS04895
uniprot id: Q8KDI2
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

194439:AYT24 RS02495
gene id: 194439:AYT24_RS02495
uniprot id: Q8KF02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

194439:AYT24 RS08520
gene id: 194439:AYT24_RS08520
uniprot id: Q8KBA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS02040
gene id: 194439:AYT24_RS02040
uniprot id: Q8KFA6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

194439:AYT24 RS00105
gene id: 194439:AYT24_RS00105
uniprot id: Q8KGE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

194439:AYT24 RS00460
gene id: 194439:AYT24_RS00460
uniprot id: Q8KG75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

194439:AYT24 RS09545
gene id: 194439:AYT24_RS09545
uniprot id: Q8KAP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

194439:AYT24 RS03660
gene id: 194439:AYT24_RS03660
uniprot id: Q8KEA8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

194439:AYT24 RS04990
gene id: 194439:AYT24_RS04990
uniprot id: Q8KDG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

194439:AYT24 RS05750
gene id: 194439:AYT24_RS05750
uniprot id: Q8KCY5
names: Similarity
messages: Belongs to the LOG family.

194439:AYT24 RS07190
gene id: 194439:AYT24_RS07190
uniprot id: Q8KC36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS10250
gene id: 194439:AYT24_RS10250
uniprot id: Q8KAA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

194439:AYT24 RS06945
gene id: 194439:AYT24_RS06945
uniprot id: Q8KC88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

194439:AYT24 RS00125
gene id: 194439:AYT24_RS00125
uniprot id: Q8KGE4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

194439:AYT24 RS08370
gene id: 194439:AYT24_RS08370
uniprot id: Q8KBD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

194439:AYT24 RS00555
gene id: 194439:AYT24_RS00555
uniprot id: Q8KG54
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

194439:AYT24 RS06375
gene id: 194439:AYT24_RS06375
uniprot id: Q8KCK5
names: Similarity
messages: Belongs to the UPF0047 family.

194439:AYT24 RS03245
gene id: 194439:AYT24_RS03245
uniprot id: Q8KEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

194439:AYT24 RS02860
gene id: 194439:AYT24_RS02860
uniprot id: Q8KES1
names: Similarity
messages: Belongs to the UPF0758 family.

194439:AYT24 RS09755
gene id: 194439:AYT24_RS09755
uniprot id: Q8KAK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

194439:AYT24 RS06545
gene id: 194439:AYT24_RS06545
uniprot id: Q8KCH5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

194439:AYT24 RS06445
gene id: 194439:AYT24_RS06445
uniprot id: Q8KCJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS06680
gene id: 194439:AYT24_RS06680
uniprot id: Q8KCE5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

194439:AYT24 RS00130
gene id: 194439:AYT24_RS00130
uniprot id: Q8KGE2
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

194439:AYT24 RS01415
gene id: 194439:AYT24_RS01415
uniprot id: Q8KFN7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

194439:AYT24 RS03930
gene id: 194439:AYT24_RS03930
uniprot id: Q8KE49
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

194439:AYT24 RS02985
gene id: 194439:AYT24_RS02985
uniprot id: Q8KEP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane

194439:AYT24 RS05965
gene id: 194439:AYT24_RS05965
uniprot id: Q8KCU3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

194439:AYT24 RS08280
gene id: 194439:AYT24_RS08280
uniprot id: Q8KBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

194439:AYT24 RS07120
gene id: 194439:AYT24_RS07120
uniprot id: Q8KC51
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

194439:AYT24 RS02565
gene id: 194439:AYT24_RS02565
uniprot id: Q8KEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

194439:AYT24 RS04270
gene id: 194439:AYT24_RS04270
uniprot id: Q8KDW5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

194439:AYT24 RS07020
gene id: 194439:AYT24_RS07020
uniprot id: Q8KC73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

194439:AYT24 RS04310
gene id: 194439:AYT24_RS04310
uniprot id: Q8KDV6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

194439:AYT24 RS01410
gene id: 194439:AYT24_RS01410
uniprot id: Q8KFN8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

194439:AYT24 RS09900
gene id: 194439:AYT24_RS09900
uniprot id: Q8KAH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

194439:AYT24 RS09480
gene id: 194439:AYT24_RS09480
uniprot id: Q8KAQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS01185
gene id: 194439:AYT24_RS01185
uniprot id: Q8KFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

194439:AYT24 RS01635
gene id: 194439:AYT24_RS01635
uniprot id: Q8KFJ7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

194439:AYT24 RS03470
gene id: 194439:AYT24_RS03470
uniprot id: Q8KEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS04370
gene id: 194439:AYT24_RS04370
uniprot id: Q8KDU4
names: Similarity
messages: Belongs to the UPF0251 family.

194439:AYT24 RS03345
gene id: 194439:AYT24_RS03345
uniprot id: Q8KEH1
names: Similarity
messages: Belongs to the TrpF family.

194439:AYT24 RS07345
gene id: 194439:AYT24_RS07345
uniprot id: Q8KC02
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

194439:AYT24 RS00810
gene id: 194439:AYT24_RS00810
uniprot id: Q8KG10
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

194439:AYT24 RS05375
gene id: 194439:AYT24_RS05375
uniprot id: Q8KD69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS08235
gene id: 194439:AYT24_RS08235
uniprot id: Q8KBG5
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS10360
gene id: 194439:AYT24_RS10360
uniprot id: Q8KA83
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

194439:AYT24 RS07270
gene id: 194439:AYT24_RS07270
uniprot id: Q8KC17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

194439:AYT24 RS00050
gene id: 194439:AYT24_RS00050
uniprot id: Q8KGF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

194439:AYT24 RS01910
gene id: 194439:AYT24_RS01910
uniprot id: Q8KFD5
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS04560
gene id: 194439:AYT24_RS04560
uniprot id: Q8KDQ6
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

194439:AYT24 RS04760
gene id: 194439:AYT24_RS04760
uniprot id: Q8KDL1
names: Similarity
messages: Belongs to the BMP lipoprotein family.

194439:AYT24 RS07335
gene id: 194439:AYT24_RS07335
uniprot id: Q8KC04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

194439:AYT24 RS04690
gene id: 194439:AYT24_RS04690
uniprot id: Q8KDM7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 1 heme group per subunit.
messages: C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c and which then may be used for reductive CO(2) fixation.
messages: Cysteine persulfide at Cys-247.
messages: Heterodimer of SoxA and SoxX. The SoxAX complex interacts with CT1020, SoxAX-binding protein SaxB (SoxK); this interaction seems to be between SoxA and CT1020 and stimulates catalytic activity of the SoxAX complex.
messages: Periplasm

194439:AYT24 RS02895
gene id: 194439:AYT24_RS02895
uniprot id: Q8KER5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

194439:AYT24 RS09295
gene id: 194439:AYT24_RS09295
uniprot id: Q8KAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

194439:AYT24 RS04930
gene id: 194439:AYT24_RS04930
uniprot id: Q8KDH6
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

194439:AYT24 RS03185
gene id: 194439:AYT24_RS03185
uniprot id: Q8KEK4
names: Similarity
messages: Belongs to the HsdR family.

194439:AYT24 RS00560
gene id: 194439:AYT24_RS00560
uniprot id: Q8KG52
names: Similarity
messages: Belongs to the arsA ATPase family.

194439:AYT24 RS03830
gene id: 194439:AYT24_RS03830
uniprot id: Q8KE72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

194439:AYT24 RS05075
gene id: 194439:AYT24_RS05075
uniprot id: Q8KDE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

194439:AYT24 RS09860
gene id: 194439:AYT24_RS09860
uniprot id: P59031
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

194439:AYT24 RS04435
gene id: 194439:AYT24_RS04435
uniprot id: Q8KDS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

194439:AYT24 RS00025
gene id: 194439:AYT24_RS00025
uniprot id: Q8KGG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

194439:AYT24 RS07300
gene id: 194439:AYT24_RS07300
uniprot id: Q93SU4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

194439:AYT24 RS10240
gene id: 194439:AYT24_RS10240
uniprot id: Q8KAA7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

194439:AYT24 RS04835
gene id: 194439:AYT24_RS04835
uniprot id: Q8KDJ7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

194439:AYT24 RS05880
gene id: 194439:AYT24_RS05880
uniprot id: Q8KCW2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
messages: The active site is a redox-active disulfide bond.

194439:AYT24 RS03435
gene id: 194439:AYT24_RS03435
uniprot id: Q8KEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

194439:AYT24 RS08840
gene id: 194439:AYT24_RS08840
uniprot id: Q8KB39
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

194439:AYT24 RS07540
gene id: 194439:AYT24_RS07540
uniprot id: Q8KBW0
names: Similarity
messages: Belongs to the CarB family.

194439:AYT24 RS01045
gene id: 194439:AYT24_RS01045
uniprot id: Q8KFW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

194439:AYT24 RS05855
gene id: 194439:AYT24_RS05855
uniprot id: Q8KCW4
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

194439:AYT24 RS05780
gene id: 194439:AYT24_RS05780
uniprot id: Q8KCX9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

194439:AYT24 RS02650
gene id: 194439:AYT24_RS02650
uniprot id: Q8KEX0
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

194439:AYT24 RS07170
gene id: 194439:AYT24_RS07170
uniprot id: Q8KC41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

194439:AYT24 RS08780
gene id: 194439:AYT24_RS08780
uniprot id: P0A314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BChl C/E-binding protein family.
messages: Component of the photosynthetic apparatus. The light harvesting B740 complex binds bacteriochlorophyll c.
messages: chlorosome envelope

194439:AYT24 RS09865
gene id: 194439:AYT24_RS09865
uniprot id: Q8KAI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

194439:AYT24 RS00245
gene id: 194439:AYT24_RS00245
uniprot id: Q8KGB9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

194439:AYT24 RS10350
gene id: 194439:AYT24_RS10350
uniprot id: Q8KA85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits (By similarity).
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

194439:AYT24 RS05365
gene id: 194439:AYT24_RS05365
uniprot id: Q8KD71
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

194439:AYT24 RS06710
gene id: 194439:AYT24_RS06710
uniprot id: Q8KCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

194439:AYT24 RS04750
gene id: 194439:AYT24_RS04750
uniprot id: Q8KDL3
names: Similarity
messages: Belongs to the DEAD box helicase family.

194439:AYT24 RS02110
gene id: 194439:AYT24_RS02110
uniprot id: Q8KF91
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS08230
gene id: 194439:AYT24_RS08230
uniprot id: Q8KBG6
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS02830
gene id: 194439:AYT24_RS02830
uniprot id: Q8KES8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

194439:AYT24 RS00330
gene id: 194439:AYT24_RS00330
uniprot id: Q8KGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

194439:AYT24 RS09920
gene id: 194439:AYT24_RS09920
uniprot id: Q8KAH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

194439:AYT24 RS05875
gene id: 194439:AYT24_RS05875
uniprot id: Q93SW1
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

194439:AYT24 RS01480
gene id: 194439:AYT24_RS01480
uniprot id: Q9F724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS08285
gene id: 194439:AYT24_RS08285
uniprot id: Q8KBF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS02300
gene id: 194439:AYT24_RS02300
uniprot id: Q8KF55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

194439:AYT24 RS01285
gene id: 194439:AYT24_RS01285
uniprot id: Q8KFR2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

194439:AYT24 RS05395
gene id: 194439:AYT24_RS05395
uniprot id: Q8KD64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

194439:AYT24 RS03440
gene id: 194439:AYT24_RS03440
uniprot id: Q8KEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

194439:AYT24 RS09445
gene id: 194439:AYT24_RS09445
uniprot id: Q8KAR4
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

194439:AYT24 RS08330
gene id: 194439:AYT24_RS08330
uniprot id: Q8KBE7
names: Similarity
messages: Belongs to the DinB family.

194439:AYT24 RS00805
gene id: 194439:AYT24_RS00805
uniprot id: Q8KG11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

194439:AYT24 RS02835
gene id: 194439:AYT24_RS02835
uniprot id: Q8KES7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

194439:AYT24 RS04020
gene id: 194439:AYT24_RS04020
uniprot id: Q8KE26
names: Similarity
messages: Belongs to the HdrA family.

194439:AYT24 RS02235
gene id: 194439:AYT24_RS02235
uniprot id: Q8KF68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS06990
gene id: 194439:AYT24_RS06990
uniprot id: Q8KC79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

194439:AYT24 RS06070
gene id: 194439:AYT24_RS06070
uniprot id: Q8KCS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

194439:AYT24 RS02865
gene id: 194439:AYT24_RS02865
uniprot id: Q8KES0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

194439:AYT24 RS00625
gene id: 194439:AYT24_RS00625
uniprot id: Q8KG37
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

194439:AYT24 RS00675
gene id: 194439:AYT24_RS00675
uniprot id: Q8KG27
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

194439:AYT24 RS04815
gene id: 194439:AYT24_RS04815
uniprot id: O68984
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

194439:AYT24 RS09815
gene id: 194439:AYT24_RS09815
uniprot id: Q8KAJ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

194439:AYT24 RS02130
gene id: 194439:AYT24_RS02130
uniprot id: Q8KF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

194439:AYT24 RS10235
gene id: 194439:AYT24_RS10235
uniprot id: Q8KAA8
names: Similarity
messages: Belongs to the peptidase S41A family.

194439:AYT24 RS03480
gene id: 194439:AYT24_RS03480
uniprot id: Q8KEE5
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

194439:AYT24 RS07955
gene id: 194439:AYT24_RS07955
uniprot id: Q8KBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

194439:AYT24 RS05225
gene id: 194439:AYT24_RS05225
uniprot id: Q8KD99
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS01590
gene id: 194439:AYT24_RS01590
uniprot id: Q8KFK6
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

194439:AYT24 RS02645
gene id: 194439:AYT24_RS02645
uniprot id: Q8KEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

194439:AYT24 RS00765
gene id: 194439:AYT24_RS00765
uniprot id: Q8KG19
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

194439:AYT24 RS04180
gene id: 194439:AYT24_RS04180
uniprot id: Q8KDY6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

194439:AYT24 RS07125
gene id: 194439:AYT24_RS07125
uniprot id: Q8KC50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

194439:AYT24 RS04725
gene id: 194439:AYT24_RS04725
uniprot id: Q8KDL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

194439:AYT24 RS07410
gene id: 194439:AYT24_RS07410
uniprot id: Q8KBZ1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

194439:AYT24 RS06780
gene id: 194439:AYT24_RS06780
uniprot id: Q46393
names: Function
names: Subunit
messages: Homotrimer. Each subunit contains 7 molecules of bacteriochlorophyll a.
messages: Intermediary in the transfer of excitation energy from the chlorophyll to the reaction centers.

194439:AYT24 RS00140
gene id: 194439:AYT24_RS00140
uniprot id: Q8KGE0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Cells lacking this gene produce only bacteriochlorophyll d (BChld).
messages: Homodimer.
messages: Involved in the biosynthesis of the major light-harvesting pigment bacteriochlorophyll c (BChlc), which confers a significant competitive advantage to green sulfur bacteria living at limiting red and near-infrared light intensities (PubMed:15090495). Catalyzes the methylation at the C-20 position of the cyclic tetrapyrrole chlorin of bacteriochlorophyll d (BChld) to produce bacteriochlorophyll c (BChlc) using S-adenosylmethionine (SAM) as a methyl source (PubMed:15090495, PubMed:16797589).

194439:AYT24 RS03770
gene id: 194439:AYT24_RS03770
uniprot id: Q8KE84
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

194439:AYT24 RS04620
gene id: 194439:AYT24_RS04620
uniprot id: Q8KDP2
names: Similarity
messages: Belongs to the YjdM family.

194439:AYT24 RS01585
gene id: 194439:AYT24_RS01585
uniprot id: Q8KFK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS06065
gene id: 194439:AYT24_RS06065
uniprot id: Q8KCS5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

194439:AYT24 RS02620
gene id: 194439:AYT24_RS02620
uniprot id: Q8KEX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

194439:AYT24 RS10030
gene id: 194439:AYT24_RS10030
uniprot id: Q8KAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS00870
gene id: 194439:AYT24_RS00870
uniprot id: Q8KFZ7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

194439:AYT24 RS06485
gene id: 194439:AYT24_RS06485
uniprot id: Q8KCI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

194439:AYT24 RS00280
gene id: 194439:AYT24_RS00280
uniprot id: Q8KGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

194439:AYT24 RS08785
gene id: 194439:AYT24_RS08785
uniprot id: Q46367
names: Subcellular Location Annotation
messages: Chlorosome

194439:AYT24 RS08175
gene id: 194439:AYT24_RS08175
uniprot id: Q8KBH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

194439:AYT24 RS07285
gene id: 194439:AYT24_RS07285
uniprot id: H2VFJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

194439:AYT24 RS02980
gene id: 194439:AYT24_RS02980
uniprot id: Q8KEQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TolB family.
messages: Periplasm

194439:AYT24 RS05185
gene id: 194439:AYT24_RS05185
uniprot id: Q8KDA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

194439:AYT24 RS09165
gene id: 194439:AYT24_RS09165
uniprot id: Q8KAX2
names: Similarity
messages: Belongs to the CinA family.

194439:AYT24 RS01905
gene id: 194439:AYT24_RS01905
uniprot id: Q8KFD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

194439:AYT24 RS08940
gene id: 194439:AYT24_RS08940
uniprot id: Q8KB21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

194439:AYT24 RS03010
gene id: 194439:AYT24_RS03010
uniprot id: Q8KEP2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

194439:AYT24 RS00260
gene id: 194439:AYT24_RS00260
uniprot id: Q8KGB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

194439:AYT24 RS00095
gene id: 194439:AYT24_RS00095
uniprot id: Q8KGF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

194439:AYT24 RS01050
gene id: 194439:AYT24_RS01050
uniprot id: Q8KFW5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

194439:AYT24 RS09945
gene id: 194439:AYT24_RS09945
uniprot id: Q8KAH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

194439:AYT24 RS07380
gene id: 194439:AYT24_RS07380
uniprot id: Q8KBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

194439:AYT24 RS03820
gene id: 194439:AYT24_RS03820
uniprot id: Q8KE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

194439:AYT24 RS03705
gene id: 194439:AYT24_RS03705
uniprot id: Q8KE97
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

194439:AYT24 RS03980
gene id: 194439:AYT24_RS03980
uniprot id: Q8KE36
names: Similarity
messages: Belongs to the DsrF/TusC family.

194439:AYT24 RS08965
gene id: 194439:AYT24_RS08965
uniprot id: Q8KB15
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

194439:AYT24 RS06415
gene id: 194439:AYT24_RS06415
uniprot id: O68992
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

194439:AYT24 RS10105
gene id: 194439:AYT24_RS10105
uniprot id: Q8KAD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS06800
gene id: 194439:AYT24_RS06800
uniprot id: Q8KCC0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

194439:AYT24 RS01510
gene id: 194439:AYT24_RS01510
uniprot id: Q8KFM1
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

194439:AYT24 RS09775
gene id: 194439:AYT24_RS09775
uniprot id: Q8KAK2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS06865
gene id: 194439:AYT24_RS06865
uniprot id: Q8KCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

194439:AYT24 RS06495
gene id: 194439:AYT24_RS06495
uniprot id: Q8KCI5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

194439:AYT24 RS09595
gene id: 194439:AYT24_RS09595
uniprot id: Q8KAN2
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

194439:AYT24 RS07405
gene id: 194439:AYT24_RS07405
uniprot id: Q8KBZ2
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

194439:AYT24 RS02290
gene id: 194439:AYT24_RS02290
uniprot id: Q8KF58
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

194439:AYT24 RS01165
gene id: 194439:AYT24_RS01165
uniprot id: Q8KFT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS04905
gene id: 194439:AYT24_RS04905
uniprot id: Q8KDI0
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

194439:AYT24 RS05565
gene id: 194439:AYT24_RS05565
uniprot id: Q8KD25
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

194439:AYT24 RS05120
gene id: 194439:AYT24_RS05120
uniprot id: Q8KDC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

194439:AYT24 RS07130
gene id: 194439:AYT24_RS07130
uniprot id: Q8KC49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

194439:AYT24 RS09410
gene id: 194439:AYT24_RS09410
uniprot id: Q8KAS0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

194439:AYT24 RS08385
gene id: 194439:AYT24_RS08385
uniprot id: Q8KBD5
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

194439:AYT24 RS09895
gene id: 194439:AYT24_RS09895
uniprot id: Q8KAI0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

194439:AYT24 RS02460
gene id: 194439:AYT24_RS02460
uniprot id: Q8KF11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

194439:AYT24 RS08160
gene id: 194439:AYT24_RS08160
uniprot id: Q8KBI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

194439:AYT24 RS09140
gene id: 194439:AYT24_RS09140
uniprot id: P58025
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Functions as an electron acceptor for pyruvate ferredoxin oxidoreductase (PFOR).
messages: Monomer.

194439:AYT24 RS06905
gene id: 194439:AYT24_RS06905
uniprot id: Q8KC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

194439:AYT24 RS05055
gene id: 194439:AYT24_RS05055
uniprot id: Q8KDE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

194439:AYT24 RS03450
gene id: 194439:AYT24_RS03450
uniprot id: Q8KEF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

194439:AYT24 RS08685
gene id: 194439:AYT24_RS08685
uniprot id: Q8KB67
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

194439:AYT24 RS06170
gene id: 194439:AYT24_RS06170
uniprot id: Q8KCQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

194439:AYT24 RS00515
gene id: 194439:AYT24_RS00515
uniprot id: Q8KG62
names: Similarity
messages: Belongs to the universal stress protein A family.

194439:AYT24 RS09370
gene id: 194439:AYT24_RS09370
uniprot id: Q8KAS8
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

194439:AYT24 RS02100
gene id: 194439:AYT24_RS02100
uniprot id: Q8KF93
names: Similarity
messages: Belongs to the GSP E family.

194439:AYT24 RS06195
gene id: 194439:AYT24_RS06195
uniprot id: Q8KCP6
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS09015
gene id: 194439:AYT24_RS09015
uniprot id: Q8KB03
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

194439:AYT24 RS01140
gene id: 194439:AYT24_RS01140
uniprot id: Q8KFU4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

194439:AYT24 RS02535
gene id: 194439:AYT24_RS02535
uniprot id: Q8KEZ2
names: Similarity
messages: Belongs to the AdoMet synthetase 2 family.

194439:AYT24 RS01645
gene id: 194439:AYT24_RS01645
uniprot id: Q8KFJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

194439:AYT24 RS06175
gene id: 194439:AYT24_RS06175
uniprot id: Q8KCQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

194439:AYT24 RS00055
gene id: 194439:AYT24_RS00055
uniprot id: Q8KGF7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

194439:AYT24 RS05385
gene id: 194439:AYT24_RS05385
uniprot id: Q8KD66
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS07595
gene id: 194439:AYT24_RS07595
uniprot id: Q8KBU9
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

194439:AYT24 RS06740
gene id: 194439:AYT24_RS06740
uniprot id: Q8KCD0
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

194439:AYT24 RS07395
gene id: 194439:AYT24_RS07395
uniprot id: Q9F719
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

194439:AYT24 RS06590
gene id: 194439:AYT24_RS06590
uniprot id: Q8KCG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS00380
gene id: 194439:AYT24_RS00380
uniprot id: Q8KG91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

194439:AYT24 RS03640
gene id: 194439:AYT24_RS03640
uniprot id: Q8KEB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS06270
gene id: 194439:AYT24_RS06270
uniprot id: Q8KCN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

194439:AYT24 RS09555
gene id: 194439:AYT24_RS09555
uniprot id: Q8KAP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

194439:AYT24 RS01810
gene id: 194439:AYT24_RS01810
uniprot id: Q8KFF6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

194439:AYT24 RS07045
gene id: 194439:AYT24_RS07045
uniprot id: Q8KC68
names: Similarity
messages: Belongs to the BshC family.

194439:AYT24 RS03490
gene id: 194439:AYT24_RS03490
uniprot id: Q8KEE3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

194439:AYT24 RS08225
gene id: 194439:AYT24_RS08225
uniprot id: Q8KBG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

194439:AYT24 RS02505
gene id: 194439:AYT24_RS02505
uniprot id: Q8KF00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

194439:AYT24 RS03500
gene id: 194439:AYT24_RS03500
uniprot id: Q8KEE1
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS05410
gene id: 194439:AYT24_RS05410
uniprot id: Q8KD61
names: Similarity
messages: Belongs to the sigma-54 factor family.

194439:AYT24 RS04900
gene id: 194439:AYT24_RS04900
uniprot id: Q8KDI1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

194439:AYT24 RS03650
gene id: 194439:AYT24_RS03650
uniprot id: Q8KEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

194439:AYT24 RS00195
gene id: 194439:AYT24_RS00195
uniprot id: Q8KGC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm

194439:AYT24 RS09345
gene id: 194439:AYT24_RS09345
uniprot id: Q8KAT5
names: Similarity
messages: Belongs to the arsA ATPase family.

194439:AYT24 RS02885
gene id: 194439:AYT24_RS02885
uniprot id: Q8KER7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

194439:AYT24 RS03935
gene id: 194439:AYT24_RS03935
uniprot id: Q8KE48
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

194439:AYT24 RS06080
gene id: 194439:AYT24_RS06080
uniprot id: Q8KCS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

194439:AYT24 RS04485
gene id: 194439:AYT24_RS04485
uniprot id: Q8KDS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

194439:AYT24 RS09080
gene id: 194439:AYT24_RS09080
uniprot id: Q8KAY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GmhB family.
messages: Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS07995
gene id: 194439:AYT24_RS07995
uniprot id: Q8KBL5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

194439:AYT24 RS08565
gene id: 194439:AYT24_RS08565
uniprot id: Q8KB95
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

194439:AYT24 RS08290
gene id: 194439:AYT24_RS08290
uniprot id: Q8KBF5
names: Similarity
messages: Belongs to the UPF0235 family.

194439:AYT24 RS06000
gene id: 194439:AYT24_RS06000
uniprot id: Q8KCT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

194439:AYT24 RS09030
gene id: 194439:AYT24_RS09030
uniprot id: Q8KAZ8
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS10150
gene id: 194439:AYT24_RS10150
uniprot id: Q8KAC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

194439:AYT24 RS01420
gene id: 194439:AYT24_RS01420
uniprot id: Q8KFN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

194439:AYT24 RS07305
gene id: 194439:AYT24_RS07305
uniprot id: Q8KC14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

194439:AYT24 RS01020
gene id: 194439:AYT24_RS01020
uniprot id: Q8KFX1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

194439:AYT24 RS01330
gene id: 194439:AYT24_RS01330
uniprot id: Q8KFQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

194439:AYT24 RS01200
gene id: 194439:AYT24_RS01200
uniprot id: Q8KFS9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

194439:AYT24 RS10345
gene id: 194439:AYT24_RS10345
uniprot id: Q8KA87
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).
messages: This protein is much smaller than the orthologs present in other bacteria; the NBD2 and C-terminal domains are missing. However, there is a paralog in the genome (clpB1) that encodes a protein which contains only the NBD2 and C-terminal domains.

194439:AYT24 RS09050
gene id: 194439:AYT24_RS09050
uniprot id: Q8KAZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

194439:AYT24 RS01900
gene id: 194439:AYT24_RS01900
uniprot id: Q8KFD7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

194439:AYT24 RS05265
gene id: 194439:AYT24_RS05265
uniprot id: Q8KD91
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

194439:AYT24 RS00255
gene id: 194439:AYT24_RS00255
uniprot id: Q8KGB7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

194439:AYT24 RS00505
gene id: 194439:AYT24_RS00505
uniprot id: Q8KG64
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS03600
gene id: 194439:AYT24_RS03600
uniprot id: Q8KEC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS07810
gene id: 194439:AYT24_RS07810
uniprot id: Q8KBQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS00790
gene id: 194439:AYT24_RS00790
uniprot id: Q8KG14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

194439:AYT24 RS03665
gene id: 194439:AYT24_RS03665
uniprot id: Q8KEA7
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

194439:AYT24 RS02035
gene id: 194439:AYT24_RS02035
uniprot id: Q8KFA7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

194439:AYT24 RS08200
gene id: 194439:AYT24_RS08200
uniprot id: Q8KBH3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

194439:AYT24 RS01235
gene id: 194439:AYT24_RS01235
uniprot id: Q8KFS2
names: Subcellular Location Annotation
messages: Cytoplasm

194439:AYT24 RS01730
gene id: 194439:AYT24_RS01730
uniprot id: Q8KFH5
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

194439:AYT24 RS08135
gene id: 194439:AYT24_RS08135
uniprot id: Q8KBI7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

194439:AYT24 RS09200
gene id: 194439:AYT24_RS09200
uniprot id: Q8KAW4
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

194439:AYT24 RS06320
gene id: 194439:AYT24_RS06320
uniprot id: Q8KCL8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

194439:AYT24 RS00715
gene id: 194439:AYT24_RS00715
uniprot id: Q8KG25
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

194439:AYT24 RS04145
gene id: 194439:AYT24_RS04145
uniprot id: Q8KDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

194439:AYT24 RS07280
gene id: 194439:AYT24_RS07280
uniprot id: Q93SU8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

194439:AYT24 RS07310
gene id: 194439:AYT24_RS07310
uniprot id: Q8KC12
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

194439:AYT24 RS00440
gene id: 194439:AYT24_RS00440
uniprot id: Q8KG79
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).
messages: This protein is much smaller than the orthologs present in other bacteria; the N-terminal and NBD1 domains are missing. However, there is a paralog in the genome (clpB2) that encodes a protein which contains only the N-terminal and NBD1 domains.

194439:AYT24 RS09950
gene id: 194439:AYT24_RS09950
uniprot id: Q8KAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

194439:AYT24 RS08000
gene id: 194439:AYT24_RS08000
uniprot id: Q8KBL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Although strongly related to RuBisCO family, it lacks the conserved Lys active site in position 327, which is replaced by an Arg residue, suggesting that it may catalyze enolization but not carboxylation.
messages: Belongs to the RuBisCO large chain family. Type IV subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: May be involved in sulfur metabolism and oxidative stress response. Does not show RuBisCO activity.

194439:AYT24 RS01855
gene id: 194439:AYT24_RS01855
uniprot id: Q8KFE6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

194439:AYT24 RS06970
gene id: 194439:AYT24_RS06970
uniprot id: Q8KC83
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

194439:AYT24 RS09225
gene id: 194439:AYT24_RS09225
uniprot id: Q8KAV9
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

194439:AYT24 RS01290
gene id: 194439:AYT24_RS01290
uniprot id: Q8KFR1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

194439:AYT24 RS06360
gene id: 194439:AYT24_RS06360
uniprot id: Q8KCK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

194439:AYT24 RS03730
gene id: 194439:AYT24_RS03730
uniprot id: Q8KE91
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

194439:AYT24 RS03620
gene id: 194439:AYT24_RS03620
uniprot id: Q8KEB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

194439:AYT24 RS07440
gene id: 194439:AYT24_RS07440
uniprot id: Q8KBY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

194439:AYT24 RS10065
gene id: 194439:AYT24_RS10065
uniprot id: Q8KAE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

194439:AYT24 RS05655
gene id: 194439:AYT24_RS05655
uniprot id: Q8KD07
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

194439:AYT24 RS00900
gene id: 194439:AYT24_RS00900
uniprot id: Q8KFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS00620
gene id: 194439:AYT24_RS00620
uniprot id: Q8KG38
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

194439:AYT24 RS09235
gene id: 194439:AYT24_RS09235
uniprot id: Q8KAV6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

194439:AYT24 RS05040
gene id: 194439:AYT24_RS05040
uniprot id: Q8KDE9
names: Subcellular Location Annotation
messages: Membrane

194439:AYT24 RS07480
gene id: 194439:AYT24_RS07480
uniprot id: Q8KBX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX (PubMed:23651039). Can bind the benzodiazepine receptor agonist PK-11195 (in vitro); this interferes with photooxidative tetrapyrrole degradation (PubMed:23651039). May play a role in the transmembrane transport of tetrapyrroles and similar compounds (By similarity).
messages: Cell membrane
messages: Membrane

194439:AYT24 RS08210
gene id: 194439:AYT24_RS08210
uniprot id: Q8KBH1
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

194439:AYT24 RS04415
gene id: 194439:AYT24_RS04415
uniprot id: Q8KDT4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

194439:AYT24 RS01525
gene id: 194439:AYT24_RS01525
uniprot id: Q8KFL8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

194439:AYT24 RS06980
gene id: 194439:AYT24_RS06980
uniprot id: Q8KC81
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

194439:AYT24 RS07360
gene id: 194439:AYT24_RS07360
uniprot id: Q8KBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

194439:AYT24 RS09145
gene id: 194439:AYT24_RS09145
uniprot id: Q8KAX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

194439:AYT24 RS02690
gene id: 194439:AYT24_RS02690
uniprot id: Q8KEW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

194439:AYT24 RS10170
gene id: 194439:AYT24_RS10170
uniprot id: Q8KAB9
names: Subcellular Location Annotation
messages: Membrane