188937:MA RS07230
gene id: 188937:MA_RS07230
uniprot id: Q8TQZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

188937:MA RS08680
gene id: 188937:MA_RS08680
uniprot id: Q8TQ77
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS16720
gene id: 188937:MA_RS16720
uniprot id: Q8TL41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

188937:MA RS15790
gene id: 188937:MA_RS15790
uniprot id: Q8TLM0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

188937:MA RS21700
gene id: 188937:MA_RS21700
uniprot id: Q8TIJ0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

188937:MA RS11855
gene id: 188937:MA_RS11855
uniprot id: Q8TNK0
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS03105
gene id: 188937:MA_RS03105
uniprot id: Q8TT47
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

188937:MA RS18985
gene id: 188937:MA_RS18985
uniprot id: Q8TJY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS02660
gene id: 188937:MA_RS02660
uniprot id: Q8TTC6
names: Similarity
messages: Belongs to the UPF0228 family.

188937:MA RS00125
gene id: 188937:MA_RS00125
uniprot id: Q8TUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

188937:MA RS18560
gene id: 188937:MA_RS18560
uniprot id: Q8TK62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

188937:MA RS04845
gene id: 188937:MA_RS04845
uniprot id: Q8TS71
names: Function
names: Similarity
messages: Acts as a methyl group carrier between MtbB and MtbA.
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS18230
gene id: 188937:MA_RS18230
uniprot id: Q8TKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

188937:MA RS03780
gene id: 188937:MA_RS03780
uniprot id: Q8TSS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

188937:MA RS20215
gene id: 188937:MA_RS20215
uniprot id: Q8TJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

188937:MA RS04265
gene id: 188937:MA_RS04265
uniprot id: Q8TSH7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

188937:MA RS19245
gene id: 188937:MA_RS19245
uniprot id: Q8TJT3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

188937:MA RS20265
gene id: 188937:MA_RS20265
uniprot id: Q8TJA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS03340
gene id: 188937:MA_RS03340
uniprot id: Q8TT07
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

188937:MA RS00385
gene id: 188937:MA_RS00385
uniprot id: Q8TUJ2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

188937:MA RS08970
gene id: 188937:MA_RS08970
uniprot id: Q8TQ25
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

188937:MA RS17990
gene id: 188937:MA_RS17990
uniprot id: Q8TKG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

188937:MA RS18915
gene id: 188937:MA_RS18915
uniprot id: Q8TJZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Homodimer or monomer (By similarity). The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD (PubMed:27846569).
messages: Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.

188937:MA RS02730
gene id: 188937:MA_RS02730
uniprot id: Q8TTB4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

188937:MA RS21190
gene id: 188937:MA_RS21190
uniprot id: Q8TIT1
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

188937:MA RS13800
gene id: 188937:MA_RS13800
uniprot id: Q8TMK7
names: Similarity
messages: Belongs to the sulfatase family.

188937:MA RS23825
gene id: 188937:MA_RS23825
uniprot id: Q8THE7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS22635
gene id: 188937:MA_RS22635
uniprot id: Q8TI23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

188937:MA RS01115
gene id: 188937:MA_RS01115
uniprot id: Q8TU65
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

188937:MA RS07665
gene id: 188937:MA_RS07665
uniprot id: Q8TQR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

188937:MA RS19435
gene id: 188937:MA_RS19435
uniprot id: Q8TJQ0
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

188937:MA RS01580
gene id: 188937:MA_RS01580
uniprot id: Q8TTX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS01985
gene id: 188937:MA_RS01985
uniprot id: Q8TTP7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

188937:MA RS04575
gene id: 188937:MA_RS04575
uniprot id: Q8TSB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS08200
gene id: 188937:MA_RS08200
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS12645
gene id: 188937:MA_RS12645
uniprot id: Q8TN58
names: Function
names: Subcellular Location Annotation
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

188937:MA RS22660
gene id: 188937:MA_RS22660
uniprot id: Q8TI20
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS10455
gene id: 188937:MA_RS10455
uniprot id: Q8TPA6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Calcium transport is inhibited by Na(+), K(+), Li(+), Mg(2+) or Mn(2+).
messages: Catalyzes Na(+)/Ca(2+) exchange. The transport is electrogenic with a likely stoichiometry of 3 or more Na(+) for each Ca(2+). Is K(+)-independent.
messages: Cell membrane

188937:MA RS11650
gene id: 188937:MA_RS11650
uniprot id: Q8TNN7
names: Similarity
messages: Belongs to the serpin family.

188937:MA RS05975
gene id: 188937:MA_RS05975
uniprot id: Q8TRM8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

188937:MA RS00205
gene id: 188937:MA_RS00205
uniprot id: Q8TUM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

188937:MA RS00930
gene id: 188937:MA_RS00930
uniprot id: Q8TUA2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

188937:MA RS03065
gene id: 188937:MA_RS03065
uniprot id: P58886
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

188937:MA RS18425
gene id: 188937:MA_RS18425
uniprot id: Q8TK87
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

188937:MA RS16615
gene id: 188937:MA_RS16615
uniprot id: Q8TL61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

188937:MA RS01435
gene id: 188937:MA_RS01435
uniprot id: Q8TU05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS21200
gene id: 188937:MA_RS21200
uniprot id: Q8TIS9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

188937:MA RS16690
gene id: 188937:MA_RS16690
uniprot id: Q8TL47
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

188937:MA RS22255
gene id: 188937:MA_RS22255
uniprot id: Q8TI94
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

188937:MA RS24635
gene id: 188937:MA_RS24635
uniprot id: Q8TMH6
names: Subcellular Location Annotation
messages: Cell membrane

188937:MA RS05610
gene id: 188937:MA_RS05610
uniprot id: Q8TRU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

188937:MA RS10950
gene id: 188937:MA_RS10950
uniprot id: Q8TP17
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18905
gene id: 188937:MA_RS18905
uniprot id: Q8TK00
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source (Potential). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:27846569). Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source (PubMed:27846569).
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

188937:MA RS22955
gene id: 188937:MA_RS22955
uniprot id: F1SVG6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS01375
gene id: 188937:MA_RS01375
uniprot id: Q8TH26
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

188937:MA RS15875
gene id: 188937:MA_RS15875
uniprot id: Q8TLK5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

188937:MA RS10785
gene id: 188937:MA_RS10785
uniprot id: Q8TP43
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18690
gene id: 188937:MA_RS18690
uniprot id: Q8TK38
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS23180
gene id: 188937:MA_RS23180
uniprot id: Q8THS6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

188937:MA RS01265
gene id: 188937:MA_RS01265
uniprot id: Q8TU38
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

188937:MA RS03160
gene id: 188937:MA_RS03160
uniprot id: Q8TT38
names: Similarity
messages: Belongs to the MEMO1 family.

188937:MA RS10955
gene id: 188937:MA_RS10955
uniprot id: Q8TP16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS01540
gene id: 188937:MA_RS01540
uniprot id: Q8TTY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

188937:MA RS04515
gene id: 188937:MA_RS04515
uniprot id: Q8TSD1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS05275
gene id: 188937:MA_RS05275
uniprot id: Q8TRZ9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

188937:MA RS12580
gene id: 188937:MA_RS12580
uniprot id: Q8TN69
names: Function
names: Similarity
messages: Acts as a methyl group carrier between MtbB and MtbA.
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS05705
gene id: 188937:MA_RS05705
uniprot id: Q8TRS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

188937:MA RS19440
gene id: 188937:MA_RS19440
uniprot id: Q8TJP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

188937:MA RS20550
gene id: 188937:MA_RS20550
uniprot id: Q8TJ50
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

188937:MA RS03725
gene id: 188937:MA_RS03725
uniprot id: Q8TST4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS06285
gene id: 188937:MA_RS06285
uniprot id: Q8TRH1
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

188937:MA RS05045
gene id: 188937:MA_RS05045
uniprot id: Q8TS37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

188937:MA RS24170
gene id: 188937:MA_RS24170
uniprot id: Q8TH90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeosine synthase type 1 family.
messages: Forms a robust complex with the archaeosine synthase beta subunit RaSEA. Formation of this complex highly increases lysine transfer activity (PubMed:31740832). The complex likely consists of an alpha(2)beta(2) heterotetrameric structure (By similarity).
messages: Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine.

188937:MA RS07310
gene id: 188937:MA_RS07310
uniprot id: Q8TQX8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.

188937:MA RS22330
gene id: 188937:MA_RS22330
uniprot id: Q8TI79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

188937:MA RS13100
gene id: 188937:MA_RS13100
uniprot id: P58863
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

188937:MA RS19460
gene id: 188937:MA_RS19460
uniprot id: Q8TJP6
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

188937:MA RS16330
gene id: 188937:MA_RS16330
uniprot id: Q8TLB4
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS05660
gene id: 188937:MA_RS05660
uniprot id: Q8TRT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

188937:MA RS07900
gene id: 188937:MA_RS07900
uniprot id: Q8TQL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

188937:MA RS05675
gene id: 188937:MA_RS05675
uniprot id: Q8TRT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

188937:MA RS23555
gene id: 188937:MA_RS23555
uniprot id: Q8THJ8
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

188937:MA RS04995
gene id: 188937:MA_RS04995
uniprot id: Q8TS44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

188937:MA RS05335
gene id: 188937:MA_RS05335
uniprot id: Q8TRZ1
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

188937:MA RS03115
gene id: 188937:MA_RS03115
uniprot id: Q8TT45
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

188937:MA RS22550
gene id: 188937:MA_RS22550
uniprot id: Q8TI38
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

188937:MA RS01715
gene id: 188937:MA_RS01715
uniprot id: Q8TTV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS00815
gene id: 188937:MA_RS00815
uniprot id: Q8TUC0
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the PylC family.
messages: Binds 2 magnesium ions per subunit.
messages: Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine.
messages: Is required for the biosynthesis of pyrrolysine (PubMed:17204561, PubMed:21455182). Catalyzes the ATP-dependent ligation between (3R)-3-methyl-D-ornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6-L-lysine (PubMed:21455182).

188937:MA RS08030
gene id: 188937:MA_RS08030
uniprot id: Q8TQJ7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS02725
gene id: 188937:MA_RS02725
uniprot id: Q8TTB5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

188937:MA RS01460
gene id: 188937:MA_RS01460
uniprot id: Q8TU00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS00555
gene id: 188937:MA_RS00555
uniprot id: Q8TUG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

188937:MA RS10960
gene id: 188937:MA_RS10960
uniprot id: Q8TP15
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

188937:MA RS11450
gene id: 188937:MA_RS11450
uniprot id: Q8TNS3
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS01450
gene id: 188937:MA_RS01450
uniprot id: Q8TU02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS00750
gene id: 188937:MA_RS00750
uniprot id: Q8TUC6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS15680
gene id: 188937:MA_RS15680
uniprot id: Q8TLP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

188937:MA RS04735
gene id: 188937:MA_RS04735
uniprot id: Q8TS91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

188937:MA RS03800
gene id: 188937:MA_RS03800
uniprot id: Q8TSR9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

188937:MA RS09380
gene id: 188937:MA_RS09380
uniprot id: Q8TPV0
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: May be part of a complex composed of 3 subunits; MtxA, MtxH and MtxX.

188937:MA RS17680
gene id: 188937:MA_RS17680
uniprot id: Q8TKL5
names: Similarity
messages: Belongs to the serpin family.

188937:MA RS10485
gene id: 188937:MA_RS10485
uniprot id: Q8TPA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-M subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in trans to edit the amino acid moiety from mischarged charged tRNA(Ala).

188937:MA RS20275
gene id: 188937:MA_RS20275
uniprot id: Q8TJA1
names: Similarity
messages: Belongs to the UPF0284 family.

188937:MA RS18100
gene id: 188937:MA_RS18100
uniprot id: Q8TKE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS08400
gene id: 188937:MA_RS08400
uniprot id: F1SVI3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS06510
gene id: 188937:MA_RS06510
uniprot id: P61929
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

188937:MA RS02415
gene id: 188937:MA_RS02415
uniprot id: Q8TTH3
names: Function
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 6 (HDG) family.
messages: Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.

188937:MA RS01170
gene id: 188937:MA_RS01170
uniprot id: Q8TU56
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

188937:MA RS02305
gene id: 188937:MA_RS02305
uniprot id: Q8TGX9
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

188937:MA RS06335
gene id: 188937:MA_RS06335
uniprot id: Q8TRG2
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

188937:MA RS21480
gene id: 188937:MA_RS21480
uniprot id: Q8TIM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

188937:MA RS01495
gene id: 188937:MA_RS01495
uniprot id: Q8TTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS17605
gene id: 188937:MA_RS17605
uniprot id: Q8TKM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

188937:MA RS21925
gene id: 188937:MA_RS21925
uniprot id: Q8TIF2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

188937:MA RS20910
gene id: 188937:MA_RS20910
uniprot id: Q8TIY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

188937:MA RS14175
gene id: 188937:MA_RS14175
uniprot id: Q8TMF0
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS19235
gene id: 188937:MA_RS19235
uniprot id: Q8TJT5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

188937:MA RS04645
gene id: 188937:MA_RS04645
uniprot id: Q8TSA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

188937:MA RS06075
gene id: 188937:MA_RS06075
uniprot id: Q8TRK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

188937:MA RS17360
gene id: 188937:MA_RS17360
uniprot id: Q8TKS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

188937:MA RS02185
gene id: 188937:MA_RS02185
uniprot id: Q8TTL3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

188937:MA RS05255
gene id: 188937:MA_RS05255
uniprot id: Q8TS03
names: Similarity
messages: Belongs to the Fur family.

188937:MA RS17050
gene id: 188937:MA_RS17050
uniprot id: Q8TKX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. MptN subfamily.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the ATP or GTP-dependent addition of one L-glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.
messages: Homodimer.

188937:MA RS19880
gene id: 188937:MA_RS19880
uniprot id: Q8TJG8
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

188937:MA RS00045
gene id: 188937:MA_RS00045
uniprot id: Q8TUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

188937:MA RS18910
gene id: 188937:MA_RS18910
uniprot id: Q8TJZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Homodimer (By similarity). The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD (PubMed:27846569).
messages: Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.

188937:MA RS16915
gene id: 188937:MA_RS16915
uniprot id: Q8TL02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

188937:MA RS08570
gene id: 188937:MA_RS08570
uniprot id: Q8TQ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

188937:MA RS14750
gene id: 188937:MA_RS14750
uniprot id: Q8TM55
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

188937:MA RS03760
gene id: 188937:MA_RS03760
uniprot id: Q8TSS7
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

188937:MA RS11135
gene id: 188937:MA_RS11135
uniprot id: Q8TNY3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

188937:MA RS03205
gene id: 188937:MA_RS03205
uniprot id: Q8TT29
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

188937:MA RS06000
gene id: 188937:MA_RS06000
uniprot id: Q8TRM3
names: Similarity
messages: Belongs to the FBPase class 2 family.

188937:MA RS18895
gene id: 188937:MA_RS18895
uniprot id: Q8TGX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
messages: Homodimer.

188937:MA RS00120
gene id: 188937:MA_RS00120
uniprot id: Q8TUP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS21695
gene id: 188937:MA_RS21695
uniprot id: Q8TIJ1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

188937:MA RS21180
gene id: 188937:MA_RS21180
uniprot id: Q8TIT3
names: Similarity
messages: Belongs to the SUI1 family.

188937:MA RS04895
gene id: 188937:MA_RS04895
uniprot id: Q8TS63
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

188937:MA RS05645
gene id: 188937:MA_RS05645
uniprot id: Q8TRT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

188937:MA RS06325
gene id: 188937:MA_RS06325
uniprot id: Q8TRG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

188937:MA RS13710
gene id: 188937:MA_RS13710
uniprot id: Q8TMM4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS11145
gene id: 188937:MA_RS11145
uniprot id: Q8TNY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS09775
gene id: 188937:MA_RS09775
uniprot id: Q8TPN2
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

188937:MA RS02385
gene id: 188937:MA_RS02385
uniprot id: F1SVM3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS09270
gene id: 188937:MA_RS09270
uniprot id: Q8TPX0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

188937:MA RS00070
gene id: 188937:MA_RS00070
uniprot id: Q8TUQ0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

188937:MA RS19385
gene id: 188937:MA_RS19385
uniprot id: Q8TJQ9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

188937:MA RS04935
gene id: 188937:MA_RS04935
uniprot id: Q8TS56
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

188937:MA RS05620
gene id: 188937:MA_RS05620
uniprot id: Q8TRU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

188937:MA RS20460
gene id: 188937:MA_RS20460
uniprot id: Q8TJ69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS13905
gene id: 188937:MA_RS13905
uniprot id: Q8TMJ0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

188937:MA RS05950
gene id: 188937:MA_RS05950
uniprot id: Q8TRN3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

188937:MA RS09460
gene id: 188937:MA_RS09460
uniprot id: Q8TPT8
names: Similarity
messages: Belongs to the DMRL synthase family.

188937:MA RS01415
gene id: 188937:MA_RS01415
uniprot id: Q8TU10
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

188937:MA RS16090
gene id: 188937:MA_RS16090
uniprot id: Q8TLF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

188937:MA RS20895
gene id: 188937:MA_RS20895
uniprot id: Q8TIY4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS12650
gene id: 188937:MA_RS12650
uniprot id: Q8TN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

188937:MA RS05640
gene id: 188937:MA_RS05640
uniprot id: Q8TRT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

188937:MA RS03430
gene id: 188937:MA_RS03430
uniprot id: Q8TSZ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

188937:MA RS05005
gene id: 188937:MA_RS05005
uniprot id: Q8TS42
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

188937:MA RS00005
gene id: 188937:MA_RS00005
uniprot id: Q8TUR2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

188937:MA RS18555
gene id: 188937:MA_RS18555
uniprot id: Q8TK63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

188937:MA RS00025
gene id: 188937:MA_RS00025
uniprot id: Q8TUQ9
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

188937:MA RS21395
gene id: 188937:MA_RS21395
uniprot id: Q9HHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

188937:MA RS01085
gene id: 188937:MA_RS01085
uniprot id: Q8TU71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

188937:MA RS22620
gene id: 188937:MA_RS22620
uniprot id: Q8TI26
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

188937:MA RS04985
gene id: 188937:MA_RS04985
uniprot id: Q8TS46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

188937:MA RS06150
gene id: 188937:MA_RS06150
uniprot id: Q8TRJ3
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS12990
gene id: 188937:MA_RS12990
uniprot id: Q8TMZ6
names: Similarity
messages: Belongs to the class-I fumarase family.

188937:MA RS05725
gene id: 188937:MA_RS05725
uniprot id: Q8TRS1
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

188937:MA RS01075
gene id: 188937:MA_RS01075
uniprot id: Q8TU73
names: Similarity
messages: Belongs to the UPF0166 family.

188937:MA RS12000
gene id: 188937:MA_RS12000
uniprot id: Q8TNH5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

188937:MA RS16920
gene id: 188937:MA_RS16920
uniprot id: Q8TL01
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

188937:MA RS07510
gene id: 188937:MA_RS07510
uniprot id: Q8TQU2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

188937:MA RS20230
gene id: 188937:MA_RS20230
uniprot id: Q8TJA9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

188937:MA RS05630
gene id: 188937:MA_RS05630
uniprot id: Q8TRU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

188937:MA RS05695
gene id: 188937:MA_RS05695
uniprot id: Q8TRS7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

188937:MA RS03915
gene id: 188937:MA_RS03915
uniprot id: Q8TSP6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

188937:MA RS12620
gene id: 188937:MA_RS12620
uniprot id: Q8TN63
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

188937:MA RS10695
gene id: 188937:MA_RS10695
uniprot id: Q8TP62
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS07810
gene id: 188937:MA_RS07810
uniprot id: Q8TQN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

188937:MA RS21460
gene id: 188937:MA_RS21460
uniprot id: Q8TIN3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

188937:MA RS07480
gene id: 188937:MA_RS07480
uniprot id: Q8TQV0
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudC subfamily.

188937:MA RS21265
gene id: 188937:MA_RS21265
uniprot id: Q8TIR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

188937:MA RS00620
gene id: 188937:MA_RS00620
uniprot id: Q8TUE8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

188937:MA RS21165
gene id: 188937:MA_RS21165
uniprot id: Q8TIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

188937:MA RS06230
gene id: 188937:MA_RS06230
uniprot id: Q8TRH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS05670
gene id: 188937:MA_RS05670
uniprot id: Q8TRT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

188937:MA RS03930
gene id: 188937:MA_RS03930
uniprot id: Q8TSP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

188937:MA RS11455
gene id: 188937:MA_RS11455
uniprot id: Q8TNS2
names: Function
messages: Part of a potassium transport system.

188937:MA RS22700
gene id: 188937:MA_RS22700
uniprot id: Q8TI14
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS05710
gene id: 188937:MA_RS05710
uniprot id: Q8TRS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

188937:MA RS11120
gene id: 188937:MA_RS11120
uniprot id: Q8TNY7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

188937:MA RS10480
gene id: 188937:MA_RS10480
uniprot id: Q8TPA1
names: Subcellular Location Annotation
messages: Cell inner membrane

188937:MA RS05685
gene id: 188937:MA_RS05685
uniprot id: Q8TRS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

188937:MA RS22165
gene id: 188937:MA_RS22165
uniprot id: Q8TIB0
names: Similarity
messages: Belongs to the UPF0251 family.

188937:MA RS22685
gene id: 188937:MA_RS22685
uniprot id: Q8TI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

188937:MA RS00695
gene id: 188937:MA_RS00695
uniprot id: P58812
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

188937:MA RS07700
gene id: 188937:MA_RS07700
uniprot id: Q8TQQ7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08295
gene id: 188937:MA_RS08295
uniprot id: Q8TQE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS20545
gene id: 188937:MA_RS20545
uniprot id: Q8TJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

188937:MA RS21205
gene id: 188937:MA_RS21205
uniprot id: Q8TIS8
names: Similarity
messages: Belongs to the AAA ATPase family.

188937:MA RS08980
gene id: 188937:MA_RS08980
uniprot id: Q8TQ23
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS04680
gene id: 188937:MA_RS04680
uniprot id: Q8TSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

188937:MA RS23350
gene id: 188937:MA_RS23350
uniprot id: Q8THP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

188937:MA RS01135
gene id: 188937:MA_RS01135
uniprot id: Q8TU61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

188937:MA RS13930
gene id: 188937:MA_RS13930
uniprot id: Q8TMI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

188937:MA RS11860
gene id: 188937:MA_RS11860
uniprot id: Q8TNJ9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS03770
gene id: 188937:MA_RS03770
uniprot id: Q8TSS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

188937:MA RS09465
gene id: 188937:MA_RS09465
uniprot id: Q8TPT7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

188937:MA RS00395
gene id: 188937:MA_RS00395
uniprot id: P60459
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

188937:MA RS04865
gene id: 188937:MA_RS04865
uniprot id: Q8TS68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS22305
gene id: 188937:MA_RS22305
uniprot id: Q8TI84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

188937:MA RS06830
gene id: 188937:MA_RS06830
uniprot id: Q8TR65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

188937:MA RS16210
gene id: 188937:MA_RS16210
uniprot id: Q8TLD8
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS11660
gene id: 188937:MA_RS11660
uniprot id: Q8TNN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

188937:MA RS22125
gene id: 188937:MA_RS22125
uniprot id: Q8TIB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrB family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.
messages: The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2.

188937:MA RS05625
gene id: 188937:MA_RS05625
uniprot id: Q8TRU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

188937:MA RS10075
gene id: 188937:MA_RS10075
uniprot id: Q8TPH8
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

188937:MA RS08775
gene id: 188937:MA_RS08775
uniprot id: Q8TQ61
names: Similarity
messages: Belongs to the UPF0210 family.

188937:MA RS09820
gene id: 188937:MA_RS09820
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS05595
gene id: 188937:MA_RS05595
uniprot id: Q8TRU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

188937:MA RS23635
gene id: 188937:MA_RS23635
uniprot id: Q8THI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

188937:MA RS23550
gene id: 188937:MA_RS23550
uniprot id: Q8THJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

188937:MA RS03150
gene id: 188937:MA_RS03150
uniprot id: Q8TT40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS06310
gene id: 188937:MA_RS06310
uniprot id: Q8TH41
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

188937:MA RS17275
gene id: 188937:MA_RS17275
uniprot id: P58859
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

188937:MA RS04250
gene id: 188937:MA_RS04250
uniprot id: Q8TSI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

188937:MA RS18520
gene id: 188937:MA_RS18520
uniprot id: Q8TK70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

188937:MA RS17650
gene id: 188937:MA_RS17650
uniprot id: Q8TKM1
names: Similarity
messages: Belongs to the glutamine synthetase family.

188937:MA RS05745
gene id: 188937:MA_RS05745
uniprot id: Q8TRR7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS07215
gene id: 188937:MA_RS07215
uniprot id: P58834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

188937:MA RS20115
gene id: 188937:MA_RS20115
uniprot id: Q8TJD0
names: Similarity
messages: Belongs to the UPF0285 family.

188937:MA RS07275
gene id: 188937:MA_RS07275
uniprot id: Q8TQY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

188937:MA RS11780
gene id: 188937:MA_RS11780
uniprot id: Q8TNL5
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS21920
gene id: 188937:MA_RS21920
uniprot id: Q8TIF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

188937:MA RS18870
gene id: 188937:MA_RS18870
uniprot id: Q8TK06
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

188937:MA RS03755
gene id: 188937:MA_RS03755
uniprot id: Q8TSS8
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cells have increased resistant to purine analogs 8-aza-2,6-diaminopurine (8-ADP) and 2-methylpurine (2MP). No change in growth rate in HS (minimal) broth.
messages: Cytoplasm
messages: Homodimer.
messages: Used for negative selection when transforming this organism.

188937:MA RS07730
gene id: 188937:MA_RS07730
uniprot id: Q8TQQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

188937:MA RS20705
gene id: 188937:MA_RS20705
uniprot id: Q8TJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

188937:MA RS20860
gene id: 188937:MA_RS20860
uniprot id: Q8TIZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS06425
gene id: 188937:MA_RS06425
uniprot id: Q8TRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS06525
gene id: 188937:MA_RS06525
uniprot id: Q8TRC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

188937:MA RS14380
gene id: 188937:MA_RS14380
uniprot id: Q8TMB9
names: Similarity
messages: Belongs to the UPF0677 family.

188937:MA RS18390
gene id: 188937:MA_RS18390
uniprot id: Q8TK95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

188937:MA RS04655
gene id: 188937:MA_RS04655
uniprot id: Q8TSA4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

188937:MA RS23815
gene id: 188937:MA_RS23815
uniprot id: Q8THE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS17655
gene id: 188937:MA_RS17655
uniprot id: Q8TKM0
names: Similarity
messages: Belongs to the UPF0145 family.

188937:MA RS19700
gene id: 188937:MA_RS19700
uniprot id: Q8TJK1
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
messages: Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals. Involved in the conversion of As(III) to a number of methylated products. Reduces the arsenic toxicity in the cell and may contribute to the global arsenic cycling.
messages: Highly dependent on the characteristics of the thiol cofactors used, with some of them (coenzyme M, homocysteine, and dithiothreitol) more efficient than GSH.

188937:MA RS05665
gene id: 188937:MA_RS05665
uniprot id: Q8TRT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

188937:MA RS12640
gene id: 188937:MA_RS12640
uniprot id: Q8TN59
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

188937:MA RS03660
gene id: 188937:MA_RS03660
uniprot id: Q8TSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS23295
gene id: 188937:MA_RS23295
uniprot id: Q8THQ1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS04525
gene id: 188937:MA_RS04525
uniprot id: Q8TSC9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS07010
gene id: 188937:MA_RS07010
uniprot id: Q8TR33
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

188937:MA RS05915
gene id: 188937:MA_RS05915
uniprot id: Q8TRN9
names: Similarity
messages: Belongs to the HypE family.

188937:MA RS09665
gene id: 188937:MA_RS09665
uniprot id: Q8TPQ4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

188937:MA RS15010
gene id: 188937:MA_RS15010
uniprot id: Q8TM11
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

188937:MA RS11965
gene id: 188937:MA_RS11965
uniprot id: Q8TNI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS05615
gene id: 188937:MA_RS05615
uniprot id: Q8TRU3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

188937:MA RS23530
gene id: 188937:MA_RS23530
uniprot id: Q8THK3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

188937:MA RS05635
gene id: 188937:MA_RS05635
uniprot id: Q8TRT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

188937:MA RS18055
gene id: 188937:MA_RS18055
uniprot id: Q8TKF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS06295
gene id: 188937:MA_RS06295
uniprot id: Q8TRG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

188937:MA RS04820
gene id: 188937:MA_RS04820
uniprot id: Q8TS74
names: Function
names: Similarity
names: Subunit
messages: Acts probably as a methyl group carrier between MttB and either MtbA or MtaA.
messages: Belongs to the methylamine corrinoid protein family.
messages: Can form a complex with MttB.

188937:MA RS19720
gene id: 188937:MA_RS19720
uniprot id: Q8TJJ7
names: Subcellular Location Annotation
messages: Cytoplasm

188937:MA RS11995
gene id: 188937:MA_RS11995
uniprot id: Q8TNH6
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS18810
gene id: 188937:MA_RS18810
uniprot id: Q8TK18
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

188937:MA RS22715
gene id: 188937:MA_RS22715
uniprot id: Q8TI11
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS14250
gene id: 188937:MA_RS14250
uniprot id: Q8TMD5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

188937:MA RS14770
gene id: 188937:MA_RS14770
uniprot id: Q8TM51
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS09980
gene id: 188937:MA_RS09980
uniprot id: Q8TPJ7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

188937:MA RS13770
gene id: 188937:MA_RS13770
uniprot id: Q8TML2
names: Similarity
messages: Belongs to the sulfatase family.

188937:MA RS21445
gene id: 188937:MA_RS21445
uniprot id: Q8TIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

188937:MA RS18225
gene id: 188937:MA_RS18225
uniprot id: Q8TKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

188937:MA RS06565
gene id: 188937:MA_RS06565
uniprot id: Q8TRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS12455
gene id: 188937:MA_RS12455
uniprot id: Q8TN93
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

188937:MA RS04710
gene id: 188937:MA_RS04710
uniprot id: Q8TS96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS06360
gene id: 188937:MA_RS06360
uniprot id: Q8TRF7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. These reactions are part of the biosynthesis pathway of coenzyme B.
messages: Functional assignment as methanogen HACN has been made based on the presence of the YLRT motif involved in substrate specificity as discussed in PubMed:20170198.
messages: Heterotetramer of 2 HacA and 2 HacB proteins. Cannot form a complex with LeuC.

188937:MA RS15885
gene id: 188937:MA_RS15885
uniprot id: Q8TLK3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

188937:MA RS24200
gene id: 188937:MA_RS24200
uniprot id: Q8TH84
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

188937:MA RS22290
gene id: 188937:MA_RS22290
uniprot id: Q8TI87
names: Similarity
messages: Belongs to the UPF0215 family.

188937:MA RS06300
gene id: 188937:MA_RS06300
uniprot id: Q8TRG8
names: Similarity
messages: Belongs to the P(II) protein family.

188937:MA RS09305
gene id: 188937:MA_RS09305
uniprot id: Q8TPW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

188937:MA RS17810
gene id: 188937:MA_RS17810
uniprot id: Q8TKJ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

188937:MA RS16885
gene id: 188937:MA_RS16885
uniprot id: Q8TL08
names: Similarity
messages: Belongs to the UPF0237 family.

188937:MA RS01805
gene id: 188937:MA_RS01805
uniprot id: Q8TTT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

188937:MA RS20985
gene id: 188937:MA_RS20985
uniprot id: Q8TIW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS02560
gene id: 188937:MA_RS02560
uniprot id: Q8TTE6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08140
gene id: 188937:MA_RS08140
uniprot id: Q8TQH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

188937:MA RS19250
gene id: 188937:MA_RS19250
uniprot id: Q8TJT2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

188937:MA RS01405
gene id: 188937:MA_RS01405
uniprot id: Q8TU12
names: Subunit
messages: Homotetramer.

188937:MA RS05895
gene id: 188937:MA_RS05895
uniprot id: Q8TRP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS05925
gene id: 188937:MA_RS05925
uniprot id: Q8TRN7
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

188937:MA RS11820
gene id: 188937:MA_RS11820
uniprot id: Q8TNK6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS22765
gene id: 188937:MA_RS22765
uniprot id: Q8TI04
names: Similarity
messages: Belongs to the alkaline phosphatase family.

188937:MA RS22190
gene id: 188937:MA_RS22190
uniprot id: Q8TIA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS20340
gene id: 188937:MA_RS20340
uniprot id: Q8TJ91
names: Similarity
messages: Belongs to the P(II) protein family.

188937:MA RS19755
gene id: 188937:MA_RS19755
uniprot id: Q8TJJ2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

188937:MA RS01420
gene id: 188937:MA_RS01420
uniprot id: Q8TU09
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

188937:MA RS17205
gene id: 188937:MA_RS17205
uniprot id: Q8TKU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. Is not able to decarboxylate the analogous compounds 2-oxoglutarate or 2-oxosuberate.

188937:MA RS20920
gene id: 188937:MA_RS20920
uniprot id: Q8TIX9
names: Subcellular Location Annotation
messages: Cell membrane

188937:MA RS22690
gene id: 188937:MA_RS22690
uniprot id: Q8TI16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

188937:MA RS01330
gene id: 188937:MA_RS01330
uniprot id: Q8TU25
names: Similarity
messages: Belongs to the citrate synthase family.

188937:MA RS18805
gene id: 188937:MA_RS18805
uniprot id: Q8TK19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

188937:MA RS17025
gene id: 188937:MA_RS17025
uniprot id: Q8TKY0
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18200
gene id: 188937:MA_RS18200
uniprot id: Q8TKC6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

188937:MA RS03140
gene id: 188937:MA_RS03140
uniprot id: Q8TT41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS06620
gene id: 188937:MA_RS06620
uniprot id: Q8TRA5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

188937:MA RS10230
gene id: 188937:MA_RS10230
uniprot id: Q8TPF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

188937:MA RS06920
gene id: 188937:MA_RS06920
uniprot id: Q8TR50
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

188937:MA RS20760
gene id: 188937:MA_RS20760
uniprot id: Q8TJ11
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

188937:MA RS05270
gene id: 188937:MA_RS05270
uniprot id: Q8TS00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

188937:MA RS08000
gene id: 188937:MA_RS08000
uniprot id: Q8TQK3
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS17160
gene id: 188937:MA_RS17160
uniprot id: Q8TKV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

188937:MA RS19450
gene id: 188937:MA_RS19450
uniprot id: Q8TJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

188937:MA RS24470
gene id: 188937:MA_RS24470
uniprot id: Q8TQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

188937:MA RS15675
gene id: 188937:MA_RS15675
uniprot id: Q8TLP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

188937:MA RS06815
gene id: 188937:MA_RS06815
uniprot id: Q8TR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

188937:MA RS03125
gene id: 188937:MA_RS03125
uniprot id: Q8TT44
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

188937:MA RS16015
gene id: 188937:MA_RS16015
uniprot id: Q8TLH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

188937:MA RS00970
gene id: 188937:MA_RS00970
uniprot id: Q8TU94
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

188937:MA RS12915
gene id: 188937:MA_RS12915
uniprot id: Q8TN09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS21095
gene id: 188937:MA_RS21095
uniprot id: Q8TIV0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

188937:MA RS07550
gene id: 188937:MA_RS07550
uniprot id: Q8TGX6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

188937:MA RS10435
gene id: 188937:MA_RS10435
uniprot id: Q8TPA9
names: Similarity
messages: Belongs to the TlyA family.

188937:MA RS15825
gene id: 188937:MA_RS15825
uniprot id: Q8TLL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS00775
gene id: 188937:MA_RS00775
uniprot id: P58869
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen decarboxylase family. MtbA/MtaA subfamily.
messages: Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase (By similarity).

188937:MA RS14560
gene id: 188937:MA_RS14560
uniprot id: Q8TM85
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

188937:MA RS22855
gene id: 188937:MA_RS22855
uniprot id: Q8THY8
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08990
gene id: 188937:MA_RS08990
uniprot id: Q8TQ21
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS10665
gene id: 188937:MA_RS10665
uniprot id: Q8TP68
names: Subcellular Location Annotation
messages: Cell membrane

188937:MA RS22925
gene id: 188937:MA_RS22925
uniprot id: Q8THX4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS19670
gene id: 188937:MA_RS19670
uniprot id: Q8TJK7
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

188937:MA RS09240
gene id: 188937:MA_RS09240
uniprot id: Q8TPX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

188937:MA RS12255
gene id: 188937:MA_RS12255
uniprot id: Q8TNC6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS03410
gene id: 188937:MA_RS03410
uniprot id: Q8TSZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

188937:MA RS17355
gene id: 188937:MA_RS17355
uniprot id: Q8TKS3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

188937:MA RS12655
gene id: 188937:MA_RS12655
uniprot id: Q8TN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

188937:MA RS09040
gene id: 188937:MA_RS09040
uniprot id: Q8TQ11
names: Function
messages: Probably involved in the biogenesis of the ribosome.

188937:MA RS24140
gene id: 188937:MA_RS24140
uniprot id: Q8TH95
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

188937:MA RS23780
gene id: 188937:MA_RS23780
uniprot id: Q8THF6
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylates: autophosphorylation is dependent on the redox state of heme cofactor and is promoted upon reduction.
messages: Cells constitutively synthesize MtsF.
messages: Cytoplasm
messages: Heme-binding is redox-active and coordinates various ligands such as imidazole, dimethyl sulfide, and carbon monoxide depending on the redox state. The redox state of the heme cofactor influences on autophosphorylation activity: while reduced protein does not autophosphorylate, oxidized protein promotes autophosphorylation signal.
messages: Heme-binding sensor kinase component part of a two-component regulatory system involved in methyl sulfide metabolism. Does not act as a phytochrome-like photoreceptor.

188937:MA RS23850
gene id: 188937:MA_RS23850
uniprot id: Q8THE3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

188937:MA RS18545
gene id: 188937:MA_RS18545
uniprot id: Q8TK65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS17915
gene id: 188937:MA_RS17915
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS22935
gene id: 188937:MA_RS22935
uniprot id: Q8THX2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

188937:MA RS23700
gene id: 188937:MA_RS23700
uniprot id: Q8THH1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (By similarity). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (By similarity).
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Is methylated on C5 of Arg-285 by the methyltransferase MA_4551. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

188937:MA RS16725
gene id: 188937:MA_RS16725
uniprot id: Q8TL39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

188937:MA RS15970
gene id: 188937:MA_RS15970
uniprot id: Q8TLI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

188937:MA RS22850
gene id: 188937:MA_RS22850
uniprot id: Q8THY9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00050
gene id: 188937:MA_RS00050
uniprot id: Q8TUQ4
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

188937:MA RS02720
gene id: 188937:MA_RS02720
uniprot id: Q8TTB6
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

188937:MA RS14100
gene id: 188937:MA_RS14100
uniprot id: Q8TMG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

188937:MA RS10930
gene id: 188937:MA_RS10930
uniprot id: Q8TP21
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

188937:MA RS18120
gene id: 188937:MA_RS18120
uniprot id: Q8TKD8
names: Similarity
messages: Belongs to the DtxR/MntR family.

188937:MA RS22695
gene id: 188937:MA_RS22695
uniprot id: Q8TI15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS03035
gene id: 188937:MA_RS03035
uniprot id: Q8TT59
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

188937:MA RS21710
gene id: 188937:MA_RS21710
uniprot id: Q8TII8
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

188937:MA RS20855
gene id: 188937:MA_RS20855
uniprot id: Q8TIZ2
names: Similarity
messages: Belongs to the UPF0288 family.

188937:MA RS13375
gene id: 188937:MA_RS13375
uniprot id: Q8TMT1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

188937:MA RS21685
gene id: 188937:MA_RS21685
uniprot id: Q8TIJ3
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

188937:MA RS23960
gene id: 188937:MA_RS23960
uniprot id: Q8THC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

188937:MA RS21380
gene id: 188937:MA_RS21380
uniprot id: Q8TIP4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

188937:MA RS19200
gene id: 188937:MA_RS19200
uniprot id: Q8TJU2
names: Similarity
messages: Belongs to the UPF0179 family.

188937:MA RS21045
gene id: 188937:MA_RS21045
uniprot id: Q8TIV9
names: Similarity
messages: Belongs to the UPF0228 family.

188937:MA RS18510
gene id: 188937:MA_RS18510
uniprot id: Q8TK72
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

188937:MA RS06685
gene id: 188937:MA_RS06685
uniprot id: Q8TR92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

188937:MA RS20930
gene id: 188937:MA_RS20930
uniprot id: Q8TIX7
names: Similarity
messages: Belongs to the PurH family.

188937:MA RS22030
gene id: 188937:MA_RS22030
uniprot id: Q8TID5
names: Similarity
messages: Belongs to the glutamate synthase family.

188937:MA RS05330
gene id: 188937:MA_RS05330
uniprot id: Q8TRZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

188937:MA RS11015
gene id: 188937:MA_RS11015
uniprot id: Q8TP05
names: Similarity
messages: Belongs to the HsdR family.

188937:MA RS09230
gene id: 188937:MA_RS09230
uniprot id: Q8TGX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

188937:MA RS12855
gene id: 188937:MA_RS12855
uniprot id: Q8TN20
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS13370
gene id: 188937:MA_RS13370
uniprot id: Q8TMT2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

188937:MA RS19530
gene id: 188937:MA_RS19530
uniprot id: Q8TJN2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

188937:MA RS07465
gene id: 188937:MA_RS07465
uniprot id: Q8TQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

188937:MA RS17565
gene id: 188937:MA_RS17565
uniprot id: Q8TKN5
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS16955
gene id: 188937:MA_RS16955
uniprot id: Q8TKZ3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

188937:MA RS22710
gene id: 188937:MA_RS22710
uniprot id: Q8TI12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

188937:MA RS06785
gene id: 188937:MA_RS06785
uniprot id: Q8TR73
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-5S] clusters per homodimer.
messages: Binds 3 [4Fe-4S] clusters per homodimer.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.
messages: Homodimer.
messages: This protein lacks the conserved Cys in positions 52 and 300; they are replaced by an Arg and a Glu, respectively. It is therefore possible that the C- and D-clusters are either altered or missing in this protein.

188937:MA RS04965
gene id: 188937:MA_RS04965
uniprot id: Q8TS50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

188937:MA RS08240
gene id: 188937:MA_RS08240
uniprot id: Q8TQF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

188937:MA RS23585
gene id: 188937:MA_RS23585
uniprot id: Q8THJ2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

188937:MA RS07485
gene id: 188937:MA_RS07485
uniprot id: Q8TQU9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

188937:MA RS16680
gene id: 188937:MA_RS16680
uniprot id: Q8TL50
names: Similarity
messages: Belongs to the UPF0047 family.

188937:MA RS08220
gene id: 188937:MA_RS08220
uniprot id: Q8TQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

188937:MA RS03180
gene id: 188937:MA_RS03180
uniprot id: Q8TT34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS17445
gene id: 188937:MA_RS17445
uniprot id: Q8TKQ6
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form (R)-homocitrate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate. These reactions are part of the biosynthesis pathway of coenzyme B and biotin.

188937:MA RS02365
gene id: 188937:MA_RS02365
uniprot id: Q8TTI1
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

188937:MA RS07805
gene id: 188937:MA_RS07805
uniprot id: Q8TQN6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS20800
gene id: 188937:MA_RS20800
uniprot id: Q8TJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

188937:MA RS24085
gene id: 188937:MA_RS24085
uniprot id: Q8THA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

188937:MA RS03605
gene id: 188937:MA_RS03605
uniprot id: Q8TSV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrD family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE.

188937:MA RS18610
gene id: 188937:MA_RS18610
uniprot id: Q8TK55
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

188937:MA RS23595
gene id: 188937:MA_RS23595
uniprot id: Q8THJ0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

188937:MA RS01820
gene id: 188937:MA_RS01820
uniprot id: Q8TTT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

188937:MA RS06475
gene id: 188937:MA_RS06475
uniprot id: Q8TRD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS06635
gene id: 188937:MA_RS06635
uniprot id: Q8TRA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

188937:MA RS07670
gene id: 188937:MA_RS07670
uniprot id: Q8TQR2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

188937:MA RS06435
gene id: 188937:MA_RS06435
uniprot id: Q8TRE2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS16730
gene id: 188937:MA_RS16730
uniprot id: Q8TL38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS06555
gene id: 188937:MA_RS06555
uniprot id: Q8TRB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS04635
gene id: 188937:MA_RS04635
uniprot id: Q8TSA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

188937:MA RS17290
gene id: 188937:MA_RS17290
uniprot id: Q8TKT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

188937:MA RS18825
gene id: 188937:MA_RS18825
uniprot id: Q8TK15
names: Similarity
messages: Belongs to the AHA1 family.

188937:MA RS14060
gene id: 188937:MA_RS14060
uniprot id: Q8TMG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

188937:MA RS06485
gene id: 188937:MA_RS06485
uniprot id: Q8TRD1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

188937:MA RS19135
gene id: 188937:MA_RS19135
uniprot id: Q8TJV6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

188937:MA RS10570
gene id: 188937:MA_RS10570
uniprot id: Q8TP84
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

188937:MA RS01800
gene id: 188937:MA_RS01800
uniprot id: Q8TTT5
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

188937:MA RS00825
gene id: 188937:MA_RS00825
uniprot id: Q8TUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

188937:MA RS01165
gene id: 188937:MA_RS01165
uniprot id: Q8TU57
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

188937:MA RS08435
gene id: 188937:MA_RS08435
uniprot id: Q8TQC4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS13250
gene id: 188937:MA_RS13250
uniprot id: Q8TMV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS20370
gene id: 188937:MA_RS20370
uniprot id: Q8TJ85
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS07910
gene id: 188937:MA_RS07910
uniprot id: Q8TQL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

188937:MA RS23710
gene id: 188937:MA_RS23710
uniprot id: Q8THG9
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

188937:MA RS15835
gene id: 188937:MA_RS15835
uniprot id: Q8TLL1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

188937:MA RS04200
gene id: 188937:MA_RS04200
uniprot id: Q8TSJ1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS23165
gene id: 188937:MA_RS23165
uniprot id: Q8THS9
names: Similarity
messages: Belongs to the thymidylate kinase family.

188937:MA RS13175
gene id: 188937:MA_RS13175
uniprot id: Q8TMW6
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

188937:MA RS20160
gene id: 188937:MA_RS20160
uniprot id: Q8TH44
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

188937:MA RS04745
gene id: 188937:MA_RS04745
uniprot id: Q8TS89
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS21825
gene id: 188937:MA_RS21825
uniprot id: Q8TH39
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

188937:MA RS10860
gene id: 188937:MA_RS10860
uniprot id: Q8TP33
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

188937:MA RS22300
gene id: 188937:MA_RS22300
uniprot id: Q8TI85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

188937:MA RS01505
gene id: 188937:MA_RS01505
uniprot id: Q8TTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

188937:MA RS14120
gene id: 188937:MA_RS14120
uniprot id: Q8TMG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Carboxyl methyltransferase with activity toward prenyl lipids. In vitro, displays activity toward N-acetyl-S-farnesyl-L-cysteine (AFC) and S-farnesylthioacetic acid (FTA), an analog of AFC.
messages: Cell membrane

188937:MA RS09475
gene id: 188937:MA_RS09475
uniprot id: Q8TPT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

188937:MA RS16410
gene id: 188937:MA_RS16410
uniprot id: Q8TLA2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

188937:MA RS17745
gene id: 188937:MA_RS17745
uniprot id: Q8TKK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

188937:MA RS08020
gene id: 188937:MA_RS08020
uniprot id: Q8TQJ9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS06825
gene id: 188937:MA_RS06825
uniprot id: Q8TR66
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

188937:MA RS03805
gene id: 188937:MA_RS03805
uniprot id: Q8TSR8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

188937:MA RS07150
gene id: 188937:MA_RS07150
uniprot id: Q8TR06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

188937:MA RS20535
gene id: 188937:MA_RS20535
uniprot id: Q8TJ54
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

188937:MA RS01770
gene id: 188937:MA_RS01770
uniprot id: Q8TTU1
names: Subcellular Location Annotation
messages: Cell membrane

188937:MA RS04345
gene id: 188937:MA_RS04345
uniprot id: Q8TSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

188937:MA RS08480
gene id: 188937:MA_RS08480
uniprot id: Q8TQB5
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

188937:MA RS23720
gene id: 188937:MA_RS23720
uniprot id: Q8THG7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

188937:MA RS06515
gene id: 188937:MA_RS06515
uniprot id: Q8TRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

188937:MA RS01250
gene id: 188937:MA_RS01250
uniprot id: Q8TU41
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS12850
gene id: 188937:MA_RS12850
uniprot id: Q8TN21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS11830
gene id: 188937:MA_RS11830
uniprot id: Q8TNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS07080
gene id: 188937:MA_RS07080
uniprot id: Q8TR21
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

188937:MA RS17795
gene id: 188937:MA_RS17795
uniprot id: Q8TKJ7
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

188937:MA RS02840
gene id: 188937:MA_RS02840
uniprot id: Q8TT96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

188937:MA RS22320
gene id: 188937:MA_RS22320
uniprot id: Q8TI81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

188937:MA RS00810
gene id: 188937:MA_RS00810
uniprot id: Q8TUC1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the PylD family.
messages: Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine.
messages: Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.

188937:MA RS12945
gene id: 188937:MA_RS12945
uniprot id: Q8TN04
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS15185
gene id: 188937:MA_RS15185
uniprot id: Q8TLX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

188937:MA RS15025
gene id: 188937:MA_RS15025
uniprot id: Q8TM08
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

188937:MA RS05605
gene id: 188937:MA_RS05605
uniprot id: Q8TRU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

188937:MA RS14245
gene id: 188937:MA_RS14245
uniprot id: Q8TMD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

188937:MA RS02300
gene id: 188937:MA_RS02300
uniprot id: Q8TTJ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS08035
gene id: 188937:MA_RS08035
uniprot id: Q8TQJ6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS12470
gene id: 188937:MA_RS12470
uniprot id: Q8TN90
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

188937:MA RS00580
gene id: 188937:MA_RS00580
uniprot id: Q8TUF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

188937:MA RS10800
gene id: 188937:MA_RS10800
uniprot id: Q8TH54
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS18090
gene id: 188937:MA_RS18090
uniprot id: Q8TKE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS17200
gene id: 188937:MA_RS17200
uniprot id: Q8TKU7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Is inhibited by AP3 (DL-2-amino-3-phosphonopropionate) and, to a lesser extent, by L-aspartate or AP4 (DL-2-amino-4-phosphonobutyrate). Is also inhibited by EDTA in vitro.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. Does not display threonine synthase activity like the paralog protein ThrC.

188937:MA RS06235
gene id: 188937:MA_RS06235
uniprot id: Q8TRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

188937:MA RS04540
gene id: 188937:MA_RS04540
uniprot id: Q8TSC6
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

188937:MA RS20935
gene id: 188937:MA_RS20935
uniprot id: Q8TIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

188937:MA RS01045
gene id: 188937:MA_RS01045
uniprot id: Q8TU79
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

188937:MA RS19750
gene id: 188937:MA_RS19750
uniprot id: Q8TJJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

188937:MA RS02535
gene id: 188937:MA_RS02535
uniprot id: Q8TTF1
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

188937:MA RS05265
gene id: 188937:MA_RS05265
uniprot id: Q8TS01
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00440
gene id: 188937:MA_RS00440
uniprot id: Q8TUI1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

188937:MA RS14830
gene id: 188937:MA_RS14830
uniprot id: Q8TM42
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

188937:MA RS10070
gene id: 188937:MA_RS10070
uniprot id: Q8TPH9
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

188937:MA RS20710
gene id: 188937:MA_RS20710
uniprot id: Q8TJ19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

188937:MA RS07290
gene id: 188937:MA_RS07290
uniprot id: Q8TQY2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00415
gene id: 188937:MA_RS00415
uniprot id: Q8TUI7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

188937:MA RS01105
gene id: 188937:MA_RS01105
uniprot id: Q8TU67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

188937:MA RS24195
gene id: 188937:MA_RS24195
uniprot id: Q8TH85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

188937:MA RS09715
gene id: 188937:MA_RS09715
uniprot id: Q8TPP4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

188937:MA RS06780
gene id: 188937:MA_RS06780
uniprot id: Q8TR74
names: Similarity
messages: Belongs to the UPF0173 family.

188937:MA RS00180
gene id: 188937:MA_RS00180
uniprot id: Q8TUN1
names: Function
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

188937:MA RS10650
gene id: 188937:MA_RS10650
uniprot id: P58850
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

188937:MA RS01440
gene id: 188937:MA_RS01440
uniprot id: Q8TU04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS20795
gene id: 188937:MA_RS20795
uniprot id: Q8TJ04
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

188937:MA RS01550
gene id: 188937:MA_RS01550
uniprot id: Q8TTY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

188937:MA RS07765
gene id: 188937:MA_RS07765
uniprot id: Q8TQP4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

188937:MA RS12730
gene id: 188937:MA_RS12730
uniprot id: Q8TN43
names: Similarity
messages: Belongs to the CutA family.

188937:MA RS22260
gene id: 188937:MA_RS22260
uniprot id: Q8TI93
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

188937:MA RS01590
gene id: 188937:MA_RS01590
uniprot id: Q8TTX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS19040
gene id: 188937:MA_RS19040
uniprot id: Q8TJX5
names: Similarity
messages: Belongs to the amidinotransferase family.

188937:MA RS02760
gene id: 188937:MA_RS02760
uniprot id: Q8TTB0
names: Function
names: Similarity
messages: Acts as a methyl group carrier between MtbB and MtbA.
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS05055
gene id: 188937:MA_RS05055
uniprot id: Q8TS35
names: Similarity
messages: Belongs to the Fur family.

188937:MA RS06320
gene id: 188937:MA_RS06320
uniprot id: Q8TRG5
names: Similarity
messages: Belongs to the P(II) protein family.

188937:MA RS19590
gene id: 188937:MA_RS19590
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS20330
gene id: 188937:MA_RS20330
uniprot id: Q8TJ93
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

188937:MA RS15525
gene id: 188937:MA_RS15525
uniprot id: Q8TLR9
names: Similarity
messages: Belongs to the AOR/FOR family.

188937:MA RS21955
gene id: 188937:MA_RS21955
uniprot id: Q8TIE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS07705
gene id: 188937:MA_RS07705
uniprot id: Q8TQQ6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains (By similarity) (PubMed:24214941). Requires the adjacently encoded ferredoxin MA_1485 as the electron donor (PubMed:24214941).
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

188937:MA RS19305
gene id: 188937:MA_RS19305
uniprot id: Q8TJS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

188937:MA RS05310
gene id: 188937:MA_RS05310
uniprot id: Q8TRZ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

188937:MA RS19745
gene id: 188937:MA_RS19745
uniprot id: Q8TJJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

188937:MA RS15055
gene id: 188937:MA_RS15055
uniprot id: Q8TM02
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 4 [4Fe-4S] cluster.
messages: Cytoplasm
messages: Induced by growth on methanol or acetate.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.
messages: The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2.

188937:MA RS06530
gene id: 188937:MA_RS06530
uniprot id: Q8TRC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

188937:MA RS05655
gene id: 188937:MA_RS05655
uniprot id: Q8TRT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

188937:MA RS04890
gene id: 188937:MA_RS04890
uniprot id: Q8TS64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

188937:MA RS04400
gene id: 188937:MA_RS04400
uniprot id: Q8TSF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS01960
gene id: 188937:MA_RS01960
uniprot id: Q8TTQ2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00715
gene id: 188937:MA_RS00715
uniprot id: Q8TUD2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

188937:MA RS00690
gene id: 188937:MA_RS00690
uniprot id: Q8TUD6
names: Similarity
messages: Belongs to the aspartokinase family.

188937:MA RS17505
gene id: 188937:MA_RS17505
uniprot id: Q8TKP6
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS21950
gene id: 188937:MA_RS21950
uniprot id: Q8TIE7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18585
gene id: 188937:MA_RS18585
uniprot id: Q8TGX2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

188937:MA RS08370
gene id: 188937:MA_RS08370
uniprot id: Q8TQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

188937:MA RS12020
gene id: 188937:MA_RS12020
uniprot id: Q8TNH2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS15925
gene id: 188937:MA_RS15925
uniprot id: Q8TLJ3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

188937:MA RS09260
gene id: 188937:MA_RS09260
uniprot id: Q8TPX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

188937:MA RS00015
gene id: 188937:MA_RS00015
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS04900
gene id: 188937:MA_RS04900
uniprot id: Q8TS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

188937:MA RS21560
gene id: 188937:MA_RS21560
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS03490
gene id: 188937:MA_RS03490
uniprot id: Q8TSX9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 5 [4Fe-4S] clusters.
messages: Cell membrane
messages: Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

188937:MA RS16345
gene id: 188937:MA_RS16345
uniprot id: Q8TLB2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrB family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cytoplasm
messages: Induced on trimethylamine or methanol, but not on acetate as the sole energy source.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis.
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA1, HdrB1 and HdrC1.
messages: Triple hdrA1C1B1 deletion decreases methane production from methanol, but does not affect methanogenesis from acetate. Deletion results in up-regulation of CoB-SH and CoM-SH synthesis and transport, and methylsulfide methyltransferases.

188937:MA RS09440
gene id: 188937:MA_RS09440
uniprot id: Q8TPU1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

188937:MA RS09960
gene id: 188937:MA_RS09960
uniprot id: Q8TPK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS09370
gene id: 188937:MA_RS09370
uniprot id: Q8TPV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

188937:MA RS06185
gene id: 188937:MA_RS06185
uniprot id: P58796
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

188937:MA RS14790
gene id: 188937:MA_RS14790
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS11130
gene id: 188937:MA_RS11130
uniprot id: Q8TNY4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

188937:MA RS07735
gene id: 188937:MA_RS07735
uniprot id: Q8TQQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

188937:MA RS21425
gene id: 188937:MA_RS21425
uniprot id: Q8TIN9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS10325
gene id: 188937:MA_RS10325
uniprot id: Q8TPD1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

188937:MA RS12060
gene id: 188937:MA_RS12060
uniprot id: Q8TNG3
names: Similarity
messages: Belongs to the UPF0047 family.

188937:MA RS24045
gene id: 188937:MA_RS24045
uniprot id: Q8THA9
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

188937:MA RS20140
gene id: 188937:MA_RS20140
uniprot id: Q8TJC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

188937:MA RS22325
gene id: 188937:MA_RS22325
uniprot id: Q8TI80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

188937:MA RS15820
gene id: 188937:MA_RS15820
uniprot id: Q8TLL4
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

188937:MA RS03395
gene id: 188937:MA_RS03395
uniprot id: P61931
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

188937:MA RS06905
gene id: 188937:MA_RS06905
uniprot id: Q8TR53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

188937:MA RS16965
gene id: 188937:MA_RS16965
uniprot id: Q8TKZ1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS23540
gene id: 188937:MA_RS23540
uniprot id: Q8THK1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. RaSEA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Forms a robust complex with the archaeosine synthase alpha subunit ArcS (PubMed:31740832). This complex likely consists of an alpha(2)beta(2) heterotetrameric structure (By similarity).
messages: Radical SAM enzyme involved in the synthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the cleavage of the C(epsilon)-N bond of the lysine moiety of q0kN15-tRNA, leading to the formation of archaeosine at position 15 in tRNAs.

188937:MA RS20975
gene id: 188937:MA_RS20975
uniprot id: Q8TIX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS02340
gene id: 188937:MA_RS02340
uniprot id: Q8TTI6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18415
gene id: 188937:MA_RS18415
uniprot id: Q8TK89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

188937:MA RS24190
gene id: 188937:MA_RS24190
uniprot id: Q8TH86
names: Subcellular Location Annotation
messages: Cytoplasm

188937:MA RS23065
gene id: 188937:MA_RS23065
uniprot id: Q8THU8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

188937:MA RS02890
gene id: 188937:MA_RS02890
uniprot id: Q8TT87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

188937:MA RS00765
gene id: 188937:MA_RS00765
uniprot id: P58867
names: Function
names: Similarity
names: Subunit
messages: Acts as a methyl group carrier between MtmB and MtbA.
messages: Belongs to the methylamine corrinoid protein family.
messages: Can form a complex with MtmB.

188937:MA RS20260
gene id: 188937:MA_RS20260
uniprot id: Q8TJA3
names: Similarity
messages: Belongs to the ZPR1 family.

188937:MA RS21690
gene id: 188937:MA_RS21690
uniprot id: Q8TIJ2
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

188937:MA RS09070
gene id: 188937:MA_RS09070
uniprot id: Q8TQ05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS05285
gene id: 188937:MA_RS05285
uniprot id: Q8TH44
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

188937:MA RS16195
gene id: 188937:MA_RS16195
uniprot id: Q8TLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

188937:MA RS06500
gene id: 188937:MA_RS06500
uniprot id: Q8TRC8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

188937:MA RS10065
gene id: 188937:MA_RS10065
uniprot id: Q8TPI0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

188937:MA RS05300
gene id: 188937:MA_RS05300
uniprot id: Q8TRZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

188937:MA RS19685
gene id: 188937:MA_RS19685
uniprot id: Q8TJK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

188937:MA RS23990
gene id: 188937:MA_RS23990
uniprot id: Q8THC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS09255
gene id: 188937:MA_RS09255
uniprot id: Q8TPX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

188937:MA RS05775
gene id: 188937:MA_RS05775
uniprot id: Q8TRR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

188937:MA RS22800
gene id: 188937:MA_RS22800
uniprot id: Q8THZ9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS01175
gene id: 188937:MA_RS01175
uniprot id: Q8TU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

188937:MA RS02360
gene id: 188937:MA_RS02360
uniprot id: Q8TTI2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

188937:MA RS21960
gene id: 188937:MA_RS21960
uniprot id: Q8TIE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

188937:MA RS12550
gene id: 188937:MA_RS12550
uniprot id: Q8TN75
names: Similarity
messages: Belongs to the HsdR family.

188937:MA RS21320
gene id: 188937:MA_RS21320
uniprot id: Q8TIQ7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS18740
gene id: 188937:MA_RS18740
uniprot id: Q8TK32
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

188937:MA RS23745
gene id: 188937:MA_RS23745
uniprot id: Q8THG2
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Reversibly inhibited by O(2).

188937:MA RS02775
gene id: 188937:MA_RS02775
uniprot id: Q8TTA8
names: Function
names: Similarity
names: Subunit
messages: Acts probably as a methyl group carrier between MttB and either MtbA or MtaA.
messages: Belongs to the methylamine corrinoid protein family.
messages: Can form a complex with MttB.

188937:MA RS08715
gene id: 188937:MA_RS08715
uniprot id: Q8TQ70
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

188937:MA RS16775
gene id: 188937:MA_RS16775
uniprot id: Q8TL28
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase M43B family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 calcium ions per subunit.
messages: Consists of two subdomains separated by an active site cleft containing the catalytic zinc ion.
messages: Inhibited by EDTA, excess zinc, and also significantly by batimastat in vitro. Is not inhibited by other metalloprotease inhibitors like phosphoramidon, captopril and galardine or those targeting other classes of proteases.
messages: Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.
messages: Monomer.
messages: The inactive zymogen pro-ulilysin undergoes calcium-mediated autolytic activation to the mature ulilysin. Autoproteolytic activation entails removal of the first 60 residues and of a highly charged 20-residue C-terminal tail.

188937:MA RS07115
gene id: 188937:MA_RS07115
uniprot id: Q8TR14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

188937:MA RS17060
gene id: 188937:MA_RS17060
uniprot id: Q8TKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

188937:MA RS15390
gene id: 188937:MA_RS15390
uniprot id: Q8TLT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS16025
gene id: 188937:MA_RS16025
uniprot id: Q8TLH2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

188937:MA RS05485
gene id: 188937:MA_RS05485
uniprot id: Q8TRW4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS06550
gene id: 188937:MA_RS06550
uniprot id: Q8TRB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS20200
gene id: 188937:MA_RS20200
uniprot id: Q8TJB5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

188937:MA RS08245
gene id: 188937:MA_RS08245
uniprot id: Q8TQF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

188937:MA RS05290
gene id: 188937:MA_RS05290
uniprot id: Q8TRZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity).

188937:MA RS24040
gene id: 188937:MA_RS24040
uniprot id: Q8THB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

188937:MA RS00460
gene id: 188937:MA_RS00460
uniprot id: Q8TUH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

188937:MA RS03080
gene id: 188937:MA_RS03080
uniprot id: Q8TT52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

188937:MA RS00720
gene id: 188937:MA_RS00720
uniprot id: Q8TUD1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

188937:MA RS05935
gene id: 188937:MA_RS05935
uniprot id: Q8TRN5
names: Similarity
messages: Belongs to the HupF/HypC family.

188937:MA RS05700
gene id: 188937:MA_RS05700
uniprot id: Q8TRS6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

188937:MA RS18325
gene id: 188937:MA_RS18325
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS20135
gene id: 188937:MA_RS20135
uniprot id: Q8TJC6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

188937:MA RS01595
gene id: 188937:MA_RS01595
uniprot id: Q8TTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS15365
gene id: 188937:MA_RS15365
uniprot id: Q8TLU3
names: Similarity
messages: Belongs to the UPF0111 family.

188937:MA RS06110
gene id: 188937:MA_RS06110
uniprot id: Q8TRK1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS05350
gene id: 188937:MA_RS05350
uniprot id: Q8TRY8
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

188937:MA RS01140
gene id: 188937:MA_RS01140
uniprot id: Q8TU60
names: Similarity
messages: Belongs to the peptidase M24B family.

188937:MA RS06270
gene id: 188937:MA_RS06270
uniprot id: Q8TH41
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

188937:MA RS20235
gene id: 188937:MA_RS20235
uniprot id: Q8TJA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

188937:MA RS11670
gene id: 188937:MA_RS11670
uniprot id: Q8TNN3
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS01645
gene id: 188937:MA_RS01645
uniprot id: Q8TTW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

188937:MA RS03740
gene id: 188937:MA_RS03740
uniprot id: Q8TST1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

188937:MA RS02255
gene id: 188937:MA_RS02255
uniprot id: Q8TTK1
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

188937:MA RS18060
gene id: 188937:MA_RS18060
uniprot id: Q8TKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS09975
gene id: 188937:MA_RS09975
uniprot id: Q8TPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS22315
gene id: 188937:MA_RS22315
uniprot id: Q8TI82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

188937:MA RS01455
gene id: 188937:MA_RS01455
uniprot id: Q8TU01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS07500
gene id: 188937:MA_RS07500
uniprot id: Q8TQU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

188937:MA RS00700
gene id: 188937:MA_RS00700
uniprot id: Q8TUD5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

188937:MA RS23730
gene id: 188937:MA_RS23730
uniprot id: Q8THG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

188937:MA RS18605
gene id: 188937:MA_RS18605
uniprot id: P58847
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

188937:MA RS13190
gene id: 188937:MA_RS13190
uniprot id: Q8TMW3
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

188937:MA RS07130
gene id: 188937:MA_RS07130
uniprot id: Q8TR11
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

188937:MA RS06055
gene id: 188937:MA_RS06055
uniprot id: Q8TRL2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

188937:MA RS19255
gene id: 188937:MA_RS19255
uniprot id: Q8TJT1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

188937:MA RS14125
gene id: 188937:MA_RS14125
uniprot id: Q8TMF9
names: Similarity
messages: Belongs to the flavodoxin family.

188937:MA RS07360
gene id: 188937:MA_RS07360
uniprot id: Q8TQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

188937:MA RS09940
gene id: 188937:MA_RS09940
uniprot id: Q8TPK6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08930
gene id: 188937:MA_RS08930
uniprot id: Q8TQ31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

188937:MA RS23765
gene id: 188937:MA_RS23765
uniprot id: Q8THF9
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS22250
gene id: 188937:MA_RS22250
uniprot id: Q8TI95
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

188937:MA RS04320
gene id: 188937:MA_RS04320
uniprot id: Q8TSG7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Methanosarcinales S-layer protein family.
messages: Cell membrane
messages: Glycosylated.
messages: S-layer
messages: S-layer protein. The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.

188937:MA RS01445
gene id: 188937:MA_RS01445
uniprot id: Q8TU03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS20390
gene id: 188937:MA_RS20390
uniprot id: Q8TJ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS03910
gene id: 188937:MA_RS03910
uniprot id: Q8TSP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

188937:MA RS14880
gene id: 188937:MA_RS14880
uniprot id: Q8TM33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

188937:MA RS23095
gene id: 188937:MA_RS23095
uniprot id: Q8THU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

188937:MA RS00530
gene id: 188937:MA_RS00530
uniprot id: Q8TUG6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the HepT RNase toxin family.
messages: Homodimer, probably forms a complex with cognate antitoxin MA_102.
messages: Modified by cognate antitoxin MA_102; probably at least 2 successive AMPylation events occur on Tyr-84.
messages: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MA_102. Neutralization may be due to AMPylation by MA_102.

188937:MA RS20355
gene id: 188937:MA_RS20355
uniprot id: Q8TJ88
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

188937:MA RS21130
gene id: 188937:MA_RS21130
uniprot id: Q8TIU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

188937:MA RS16565
gene id: 188937:MA_RS16565
uniprot id: Q8TL71
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

188937:MA RS14350
gene id: 188937:MA_RS14350
uniprot id: Q8TH54
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS18925
gene id: 188937:MA_RS18925
uniprot id: Q8TJZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (Potential). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:27846569). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (PubMed:27846569).
messages: Homotetramer; dimer of dimers.

188937:MA RS04875
gene id: 188937:MA_RS04875
uniprot id: Q8TS66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

188937:MA RS10310
gene id: 188937:MA_RS10310
uniprot id: Q8TPD4
names: Similarity
messages: Belongs to the UPF0758 family.

188937:MA RS21675
gene id: 188937:MA_RS21675
uniprot id: Q8TIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

188937:MA RS17875
gene id: 188937:MA_RS17875
uniprot id: Q8TKI1
names: Similarity
messages: Belongs to the UPF0677 family.

188937:MA RS00550
gene id: 188937:MA_RS00550
uniprot id: Q8TUG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

188937:MA RS18515
gene id: 188937:MA_RS18515
uniprot id: Q8TK71
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

188937:MA RS04040
gene id: 188937:MA_RS04040
uniprot id: Q8TSM4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS03195
gene id: 188937:MA_RS03195
uniprot id: Q8TT31
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

188937:MA RS06415
gene id: 188937:MA_RS06415
uniprot id: Q8TRE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

188937:MA RS05765
gene id: 188937:MA_RS05765
uniprot id: Q8TRR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS24210
gene id: 188937:MA_RS24210
uniprot id: Q8TH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

188937:MA RS07815
gene id: 188937:MA_RS07815
uniprot id: Q8TQN4
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS23485
gene id: 188937:MA_RS23485
uniprot id: Q8THL2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

188937:MA RS23830
gene id: 188937:MA_RS23830
uniprot id: Q8THE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS14755
gene id: 188937:MA_RS14755
uniprot id: Q8TM54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

188937:MA RS07695
gene id: 188937:MA_RS07695
uniprot id: Q8TQQ8
names: Function
messages: Part of a potassium transport system.

188937:MA RS10790
gene id: 188937:MA_RS10790
uniprot id: Q8TP42
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

188937:MA RS10300
gene id: 188937:MA_RS10300
uniprot id: Q8TPD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

188937:MA RS18920
gene id: 188937:MA_RS18920
uniprot id: Q8TJZ6
names: Function
names: Similarity
messages: Belongs to the MurCDEF family.
messages: Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the activation the g-propionate side chain of 15,17(3)-seco-F430-17(3)-acid (seco-F430) for intramolecular C-C bond formation to yield the carbocyclic F ring of coenzyme F430.

188937:MA RS00710
gene id: 188937:MA_RS00710
uniprot id: Q8TUD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

188937:MA RS14135
gene id: 188937:MA_RS14135
uniprot id: Q8TMF7
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

188937:MA RS20345
gene id: 188937:MA_RS20345
uniprot id: Q8TJ90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

188937:MA RS10550
gene id: 188937:MA_RS10550
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS22995
gene id: 188937:MA_RS22995
uniprot id: Q8THW2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

188937:MA RS19240
gene id: 188937:MA_RS19240
uniprot id: Q8TJT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

188937:MA RS06090
gene id: 188937:MA_RS06090
uniprot id: Q8TRK5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

188937:MA RS01925
gene id: 188937:MA_RS01925
uniprot id: Q8TTR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

188937:MA RS15770
gene id: 188937:MA_RS15770
uniprot id: Q8TLM4
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

188937:MA RS24030
gene id: 188937:MA_RS24030
uniprot id: Q8THB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

188937:MA RS14970
gene id: 188937:MA_RS14970
uniprot id: Q8TM19
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: This protein was originally thought to have ribose 1,5-bisphosphate isomerase activity despite the fact that some recombinant ortholog proteins were not active in vitro (PubMed:15375115, PubMed:17303759). Moreover, another protein from M.acetivorans likely possesses this activity (MA_0379). Finally, a thiamine synthase activity has been shown for the ortholog protein in M.jannaschii.

188937:MA RS22835
gene id: 188937:MA_RS22835
uniprot id: Q8THZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS07680
gene id: 188937:MA_RS07680
uniprot id: Q8TQR0
names: Function
messages: Part of a potassium transport system.

188937:MA RS20995
gene id: 188937:MA_RS20995
uniprot id: Q8TIW7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS15775
gene id: 188937:MA_RS15775
uniprot id: Q8TLM3
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

188937:MA RS15305
gene id: 188937:MA_RS15305
uniprot id: Q8TLV2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS20080
gene id: 188937:MA_RS20080
uniprot id: Q8TJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

188937:MA RS06460
gene id: 188937:MA_RS06460
uniprot id: Q8TRD6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS23975
gene id: 188937:MA_RS23975
uniprot id: Q8THC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

188937:MA RS05780
gene id: 188937:MA_RS05780
uniprot id: Q8TRR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

188937:MA RS23615
gene id: 188937:MA_RS23615
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS01430
gene id: 188937:MA_RS01430
uniprot id: Q8TU06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS03575
gene id: 188937:MA_RS03575
uniprot id: Q8TSW4
names: Similarity
messages: Belongs to the MCM family.

188937:MA RS02370
gene id: 188937:MA_RS02370
uniprot id: Q8TTI0
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

188937:MA RS19205
gene id: 188937:MA_RS19205
uniprot id: Q8TJU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

188937:MA RS00920
gene id: 188937:MA_RS00920
uniprot id: Q8TUA3
names: Similarity
messages: Belongs to the UPF0677 family.

188937:MA RS00500
gene id: 188937:MA_RS00500
uniprot id: Q8TUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

188937:MA RS00820
gene id: 188937:MA_RS00820
uniprot id: Q8TUB9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. PylB family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism (Probable). Is required for the biosynthesis of pyrrolysine.
messages: Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine.

188937:MA RS16010
gene id: 188937:MA_RS16010
uniprot id: Q8TLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

188937:MA RS20145
gene id: 188937:MA_RS20145
uniprot id: Q8TJC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

188937:MA RS06315
gene id: 188937:MA_RS06315
uniprot id: Q8TRG6
names: Similarity
messages: Belongs to the P(II) protein family.

188937:MA RS03170
gene id: 188937:MA_RS03170
uniprot id: Q8TT36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

188937:MA RS01290
gene id: 188937:MA_RS01290
uniprot id: Q8TU33
names: Similarity
messages: Belongs to the phosphohexose mutase family.

188937:MA RS23725
gene id: 188937:MA_RS23725
uniprot id: Q8THG6
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MCR alpha subunit C-methyltransferase family.
messages: Binds at least 1 [4Fe-4S] cluster. This cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cells lacking this gene produce an active MCR lacking the C(5)-methylation of the respective arginine residue. The mutant strain shows impaired growth under stress conditions, such as the presence of 0.2 mM hydrogen peroxide (H2O2) or elevated temperature (42 degrees Celsius).
messages: Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.

188937:MA RS21440
gene id: 188937:MA_RS21440
uniprot id: Q8TIN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

188937:MA RS09245
gene id: 188937:MA_RS09245
uniprot id: Q8TPX6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

188937:MA RS14890
gene id: 188937:MA_RS14890
uniprot id: Q8TM31
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS07925
gene id: 188937:MA_RS07925
uniprot id: Q8TQL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

188937:MA RS23705
gene id: 188937:MA_RS23705
uniprot id: Q8THH0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

188937:MA RS20970
gene id: 188937:MA_RS20970
uniprot id: Q8TIX1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS13090
gene id: 188937:MA_RS13090
uniprot id: Q8TMY0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

188937:MA RS20810
gene id: 188937:MA_RS20810
uniprot id: Q8TJ01
names: Similarity
messages: Belongs to the AOR/FOR family.

188937:MA RS03975
gene id: 188937:MA_RS03975
uniprot id: Q8TSN5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS01305
gene id: 188937:MA_RS01305
uniprot id: Q8TU30
names: Similarity
messages: Belongs to the UPF0107 family.

188937:MA RS06120
gene id: 188937:MA_RS06120
uniprot id: Q8TRJ9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS20635
gene id: 188937:MA_RS20635
uniprot id: Q8TJ32
names: Similarity
messages: Belongs to the DEAD box helicase family.

188937:MA RS03775
gene id: 188937:MA_RS03775
uniprot id: Q8TSS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

188937:MA RS23560
gene id: 188937:MA_RS23560
uniprot id: Q8THJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

188937:MA RS18065
gene id: 188937:MA_RS18065
uniprot id: Q8TKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS05785
gene id: 188937:MA_RS05785
uniprot id: Q8TRR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

188937:MA RS05260
gene id: 188937:MA_RS05260
uniprot id: Q8TS02
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS01410
gene id: 188937:MA_RS01410
uniprot id: Q8TU11
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

188937:MA RS05830
gene id: 188937:MA_RS05830
uniprot id: Q8TRQ6
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00840
gene id: 188937:MA_RS00840
uniprot id: Q8TUB6
names: Similarity
messages: Belongs to the UPF0251 family.

188937:MA RS04945
gene id: 188937:MA_RS04945
uniprot id: Q8TS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

188937:MA RS04410
gene id: 188937:MA_RS04410
uniprot id: Q8TSF2
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08330
gene id: 188937:MA_RS08330
uniprot id: Q8TQE2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

188937:MA RS06005
gene id: 188937:MA_RS06005
uniprot id: Q8TRM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

188937:MA RS15830
gene id: 188937:MA_RS15830
uniprot id: Q8TLL2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

188937:MA RS09035
gene id: 188937:MA_RS09035
uniprot id: Q8TQ12
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

188937:MA RS01490
gene id: 188937:MA_RS01490
uniprot id: Q8TTZ5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

188937:MA RS04750
gene id: 188937:MA_RS04750
uniprot id: Q8TS88
names: Similarity
messages: Belongs to the band 7/mec-2 family.

188937:MA RS23480
gene id: 188937:MA_RS23480
uniprot id: Q8THL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

188937:MA RS00600
gene id: 188937:MA_RS00600
uniprot id: Q8TUF2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

188937:MA RS17840
gene id: 188937:MA_RS17840
uniprot id: Q8TKI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

188937:MA RS23275
gene id: 188937:MA_RS23275
uniprot id: Q8THQ5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

188937:MA RS07505
gene id: 188937:MA_RS07505
uniprot id: Q8TQU3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

188937:MA RS05755
gene id: 188937:MA_RS05755
uniprot id: Q8TRR5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

188937:MA RS09470
gene id: 188937:MA_RS09470
uniprot id: Q8TPT6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

188937:MA RS15670
gene id: 188937:MA_RS15670
uniprot id: Q8TLP6
names: Similarity
messages: Belongs to the TrpF family.

188937:MA RS03055
gene id: 188937:MA_RS03055
uniprot id: Q8TT56
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

188937:MA RS15665
gene id: 188937:MA_RS15665
uniprot id: Q8TLP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

188937:MA RS09480
gene id: 188937:MA_RS09480
uniprot id: Q8TPT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the L-aspartate semialdehyde sulfurtransferase family.
messages: Forms homodimers. May form a complex with MA_1822.
messages: Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis (PubMed:25315403, PubMed:25938369). Together with MA_1822, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine (Probable). Likely functions through persulfide intermediate (PubMed:28165724).

188937:MA RS11325
gene id: 188937:MA_RS11325
uniprot id: Q8TNU5
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

188937:MA RS17570
gene id: 188937:MA_RS17570
uniprot id: Q8TKN4
names: Similarity
messages: Belongs to the acylphosphatase family.

188937:MA RS11410
gene id: 188937:MA_RS11410
uniprot id: Q8TH54
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS18280
gene id: 188937:MA_RS18280
uniprot id: Q8TKB4
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

188937:MA RS21735
gene id: 188937:MA_RS21735
uniprot id: Q8TII5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

188937:MA RS02855
gene id: 188937:MA_RS02855
uniprot id: Q8TT93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
messages: Cytoplasm

188937:MA RS19115
gene id: 188937:MA_RS19115
uniprot id: Q8TJW0
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

188937:MA RS04785
gene id: 188937:MA_RS04785
uniprot id: Q8TS82
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

188937:MA RS11835
gene id: 188937:MA_RS11835
uniprot id: Q8TNK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS14095
gene id: 188937:MA_RS14095
uniprot id: Q8TMG4
names: Subcellular Location Annotation
messages: Cell membrane

188937:MA RS03050
gene id: 188937:MA_RS03050
uniprot id: Q8TT57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

188937:MA RS20455
gene id: 188937:MA_RS20455
uniprot id: Q8TJ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

188937:MA RS10080
gene id: 188937:MA_RS10080
uniprot id: Q8TPH7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

188937:MA RS19535
gene id: 188937:MA_RS19535
uniprot id: Q8TJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

188937:MA RS13920
gene id: 188937:MA_RS13920
uniprot id: Q8TMI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

188937:MA RS15685
gene id: 188937:MA_RS15685
uniprot id: Q8TLP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

188937:MA RS23340
gene id: 188937:MA_RS23340
uniprot id: Q8THP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

188937:MA RS19560
gene id: 188937:MA_RS19560
uniprot id: Q8TJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

188937:MA RS01480
gene id: 188937:MA_RS01480
uniprot id: Q8TTZ7
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

188937:MA RS01300
gene id: 188937:MA_RS01300
uniprot id: Q8TU31
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS24185
gene id: 188937:MA_RS24185
uniprot id: Q8TH87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

188937:MA RS02035
gene id: 188937:MA_RS02035
uniprot id: Q8TTN9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS22965
gene id: 188937:MA_RS22965
uniprot id: F1SVF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

188937:MA RS14535
gene id: 188937:MA_RS14535
uniprot id: Q8TM90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS08875
gene id: 188937:MA_RS08875
uniprot id: Q8TQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

188937:MA RS07725
gene id: 188937:MA_RS07725
uniprot id: Q8TQQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

188937:MA RS13890
gene id: 188937:MA_RS13890
uniprot id: Q8TMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

188937:MA RS12670
gene id: 188937:MA_RS12670
uniprot id: Q8TN53
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

188937:MA RS06125
gene id: 188937:MA_RS06125
uniprot id: Q8TRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

188937:MA RS03155
gene id: 188937:MA_RS03155
uniprot id: Q8TT39
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

188937:MA RS17460
gene id: 188937:MA_RS17460
uniprot id: P58838
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

188937:MA RS19310
gene id: 188937:MA_RS19310
uniprot id: Q8TJS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

188937:MA RS20645
gene id: 188937:MA_RS20645
uniprot id: Q8TJ31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS03470
gene id: 188937:MA_RS03470
uniprot id: Q8TSY3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

188937:MA RS18085
gene id: 188937:MA_RS18085
uniprot id: Q8TKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS01180
gene id: 188937:MA_RS01180
uniprot id: P58878
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

188937:MA RS13705
gene id: 188937:MA_RS13705
uniprot id: Q8TMM5
names: Similarity
messages: Belongs to the LOR family.

188937:MA RS23965
gene id: 188937:MA_RS23965
uniprot id: Q8THC5
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

188937:MA RS21655
gene id: 188937:MA_RS21655
uniprot id: Q8TIJ9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

188937:MA RS17550
gene id: 188937:MA_RS17550
uniprot id: Q8TH26
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

188937:MA RS06305
gene id: 188937:MA_RS06305
uniprot id: Q8TRG7
names: Similarity
messages: Belongs to the P(II) protein family.

188937:MA RS17260
gene id: 188937:MA_RS17260
uniprot id: Q8TKU0
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

188937:MA RS22565
gene id: 188937:MA_RS22565
uniprot id: Q8TI36
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS22170
gene id: 188937:MA_RS22170
uniprot id: Q8TIA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

188937:MA RS22120
gene id: 188937:MA_RS22120
uniprot id: Q8TIB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrC family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.
messages: The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2.

188937:MA RS12625
gene id: 188937:MA_RS12625
uniprot id: Q8TN62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

188937:MA RS07860
gene id: 188937:MA_RS07860
uniprot id: Q8TQM6
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC3 (Potential).

188937:MA RS01720
gene id: 188937:MA_RS01720
uniprot id: Q8TTV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS08725
gene id: 188937:MA_RS08725
uniprot id: Q8TQ69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

188937:MA RS00435
gene id: 188937:MA_RS00435
uniprot id: Q8TUI2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

188937:MA RS08565
gene id: 188937:MA_RS08565
uniprot id: Q8TQ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

188937:MA RS00575
gene id: 188937:MA_RS00575
uniprot id: Q8TUF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

188937:MA RS23345
gene id: 188937:MA_RS23345
uniprot id: Q8THP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

188937:MA RS07525
gene id: 188937:MA_RS07525
uniprot id: Q8TQT9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00215
gene id: 188937:MA_RS00215
uniprot id: Q8TUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

188937:MA RS04970
gene id: 188937:MA_RS04970
uniprot id: Q8TS49
names: Cofactor
messages: Binds 1 zinc ion per subunit.

188937:MA RS14045
gene id: 188937:MA_RS14045
uniprot id: Q8TMH1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS08025
gene id: 188937:MA_RS08025
uniprot id: Q8TQJ8
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS03320
gene id: 188937:MA_RS03320
uniprot id: Q8TGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

188937:MA RS03135
gene id: 188937:MA_RS03135
uniprot id: Q8TT42
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

188937:MA RS20890
gene id: 188937:MA_RS20890
uniprot id: Q8TIY5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

188937:MA RS23740
gene id: 188937:MA_RS23740
uniprot id: Q8THG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

188937:MA RS15190
gene id: 188937:MA_RS15190
uniprot id: Q8TLX7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

188937:MA RS22055
gene id: 188937:MA_RS22055
uniprot id: P61935
names: Similarity
messages: Belongs to the UPF0228 family.

188937:MA RS01500
gene id: 188937:MA_RS01500
uniprot id: Q8TTZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS02420
gene id: 188937:MA_RS02420
uniprot id: Q8TTH2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

188937:MA RS00605
gene id: 188937:MA_RS00605
uniprot id: Q8TUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

188937:MA RS23685
gene id: 188937:MA_RS23685
uniprot id: Q8THH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

188937:MA RS03425
gene id: 188937:MA_RS03425
uniprot id: Q8TSZ2
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

188937:MA RS19620
gene id: 188937:MA_RS19620
uniprot id: Q8TJL6
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Belongs to the KdsC family.
messages: Homotetramer.

188937:MA RS07675
gene id: 188937:MA_RS07675
uniprot id: Q8TQR1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

188937:MA RS00330
gene id: 188937:MA_RS00330
uniprot id: Q8TUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS04565
gene id: 188937:MA_RS04565
uniprot id: Q8TSC1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

188937:MA RS06060
gene id: 188937:MA_RS06060
uniprot id: Q8TRL1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

188937:MA RS02070
gene id: 188937:MA_RS02070
uniprot id: Q8TTN3
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS21680
gene id: 188937:MA_RS21680
uniprot id: Q8TIJ4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

188937:MA RS00585
gene id: 188937:MA_RS00585
uniprot id: Q8TUF5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

188937:MA RS07110
gene id: 188937:MA_RS07110
uniprot id: Q8TR15
names: Similarity
messages: Belongs to the glutaredoxin family.

188937:MA RS08730
gene id: 188937:MA_RS08730
uniprot id: Q8TQ68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS17110
gene id: 188937:MA_RS17110
uniprot id: Q8TKW5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

188937:MA RS20435
gene id: 188937:MA_RS20435
uniprot id: Q8TJ74
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS19555
gene id: 188937:MA_RS19555
uniprot id: Q8TJM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

188937:MA RS20540
gene id: 188937:MA_RS20540
uniprot id: Q8TJ53
names: Similarity
messages: Belongs to the UPF0166 family.

188937:MA RS07915
gene id: 188937:MA_RS07915
uniprot id: Q8TQL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

188937:MA RS04765
gene id: 188937:MA_RS04765
uniprot id: P58862
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

188937:MA RS15965
gene id: 188937:MA_RS15965
uniprot id: Q8TLI5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

188937:MA RS18725
gene id: 188937:MA_RS18725
uniprot id: Q8TK35
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

188937:MA RS18395
gene id: 188937:MA_RS18395
uniprot id: Q8TK94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

188937:MA RS04640
gene id: 188937:MA_RS04640
uniprot id: Q8TSA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

188937:MA RS04275
gene id: 188937:MA_RS04275
uniprot id: Q8TSH5
names: Similarity
messages: Belongs to the archaeal-type GPI family.

188937:MA RS05715
gene id: 188937:MA_RS05715
uniprot id: Q8TRS3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

188937:MA RS09225
gene id: 188937:MA_RS09225
uniprot id: Q8TPX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

188937:MA RS02820
gene id: 188937:MA_RS02820
uniprot id: Q8TTA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

188937:MA RS01485
gene id: 188937:MA_RS01485
uniprot id: Q8TTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

188937:MA RS14475
gene id: 188937:MA_RS14475
uniprot id: Q8TMA3
names: Similarity
messages: Belongs to the UPF0677 family.

188937:MA RS21215
gene id: 188937:MA_RS21215
uniprot id: Q8TIS6
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

188937:MA RS09095
gene id: 188937:MA_RS09095
uniprot id: Q8TQ00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS00030
gene id: 188937:MA_RS00030
uniprot id: Q8TUQ8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

188937:MA RS06725
gene id: 188937:MA_RS06725
uniprot id: Q8TR85
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the HepT RNase toxin family.
messages: Homodimer, probably forms a complex with cognate antitoxin MA_1295.
messages: Modified by cognate antitoxin MA_1295; probably at least 2 successive AMPylation events occur on Tyr-82.
messages: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MA_1295. Neutralization may be due to AMPylation by MA_1295.

188937:MA RS15810
gene id: 188937:MA_RS15810
uniprot id: Q8TLL6
names: Function
messages: Part of a potassium transport system.

188937:MA RS10210
gene id: 188937:MA_RS10210
uniprot id: Q8TPF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

188937:MA RS04390
gene id: 188937:MA_RS04390
uniprot id: Q8TSF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS03665
gene id: 188937:MA_RS03665
uniprot id: Q8TSU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

188937:MA RS00935
gene id: 188937:MA_RS00935
uniprot id: Q8TUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

188937:MA RS05040
gene id: 188937:MA_RS05040
uniprot id: Q8TS38
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

188937:MA RS17325
gene id: 188937:MA_RS17325
uniprot id: Q8TKS9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

188937:MA RS22575
gene id: 188937:MA_RS22575
uniprot id: Q8TI34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

188937:MA RS17365
gene id: 188937:MA_RS17365
uniprot id: Q8TKS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

188937:MA RS05750
gene id: 188937:MA_RS05750
uniprot id: Q8TRR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

188937:MA RS05305
gene id: 188937:MA_RS05305
uniprot id: Q8TRZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

188937:MA RS21405
gene id: 188937:MA_RS21405
uniprot id: Q9HH99
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm
messages: Mutants are auxotrophic for proline.

188937:MA RS05470
gene id: 188937:MA_RS05470
uniprot id: Q8TRW8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS07125
gene id: 188937:MA_RS07125
uniprot id: Q8TR12
names: Similarity
messages: Belongs to the UPF0212 family.

188937:MA RS19140
gene id: 188937:MA_RS19140
uniprot id: Q8TJV5
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

188937:MA RS20990
gene id: 188937:MA_RS20990
uniprot id: Q8TIW8
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS12535
gene id: 188937:MA_RS12535
uniprot id: Q8TN78
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

188937:MA RS08905
gene id: 188937:MA_RS08905
uniprot id: Q8TQ37
names: Similarity
messages: Belongs to the UPF0280 family.

188937:MA RS09970
gene id: 188937:MA_RS09970
uniprot id: Q8TPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS03175
gene id: 188937:MA_RS03175
uniprot id: Q8TT35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

188937:MA RS06445
gene id: 188937:MA_RS06445
uniprot id: Q8TRD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

188937:MA RS21910
gene id: 188937:MA_RS21910
uniprot id: Q8TIF5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

188937:MA RS06520
gene id: 188937:MA_RS06520
uniprot id: Q8TRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

188937:MA RS03475
gene id: 188937:MA_RS03475
uniprot id: Q8TSY2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

188937:MA RS04625
gene id: 188937:MA_RS04625
uniprot id: Q8TSB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

188937:MA RS12635
gene id: 188937:MA_RS12635
uniprot id: Q8TN60
names: Similarity
messages: Belongs to the ATPase gamma chain family.

188937:MA RS21355
gene id: 188937:MA_RS21355
uniprot id: Q8TIQ0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

188937:MA RS02250
gene id: 188937:MA_RS02250
uniprot id: Q8TTK2
names: Similarity
messages: Belongs to the LarC family.

188937:MA RS23855
gene id: 188937:MA_RS23855
uniprot id: Q8THE2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

188937:MA RS10195
gene id: 188937:MA_RS10195
uniprot id: Q8TPF7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

188937:MA RS21470
gene id: 188937:MA_RS21470
uniprot id: Q8TIN0
names: Similarity
messages: Belongs to the PDCD5 family.

188937:MA RS23680
gene id: 188937:MA_RS23680
uniprot id: Q8THH5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

188937:MA RS15065
gene id: 188937:MA_RS15065
uniprot id: Q8TM00
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

188937:MA RS10165
gene id: 188937:MA_RS10165
uniprot id: Q8TPG4
names: Similarity
messages: Belongs to the group II decarboxylase family.

188937:MA RS00725
gene id: 188937:MA_RS00725
uniprot id: Q8TUD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

188937:MA RS02570
gene id: 188937:MA_RS02570
uniprot id: Q8TTE4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

188937:MA RS06420
gene id: 188937:MA_RS06420
uniprot id: Q8TRE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS22610
gene id: 188937:MA_RS22610
uniprot id: Q8TI28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

188937:MA RS16420
gene id: 188937:MA_RS16420
uniprot id: Q8TLA0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

188937:MA RS07575
gene id: 188937:MA_RS07575
uniprot id: Q8TQT0
names: Similarity
messages: Belongs to the PspA/IM30 family.

188937:MA RS21475
gene id: 188937:MA_RS21475
uniprot id: Q8TIM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

188937:MA RS16585
gene id: 188937:MA_RS16585
uniprot id: Q8TL67
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00730
gene id: 188937:MA_RS00730
uniprot id: Q8TUC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

188937:MA RS04305
gene id: 188937:MA_RS04305
uniprot id: Q8TSH0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

188937:MA RS16435
gene id: 188937:MA_RS16435
uniprot id: Q8TL97
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS20565
gene id: 188937:MA_RS20565
uniprot id: Q8TJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

188937:MA RS16205
gene id: 188937:MA_RS16205
uniprot id: Q8TLD9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS24325
gene id: 188937:MA_RS24325
uniprot id: Q8TU85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

188937:MA RS21455
gene id: 188937:MA_RS21455
uniprot id: Q8TIN4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

188937:MA RS23970
gene id: 188937:MA_RS23970
uniprot id: Q8THC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

188937:MA RS15570
gene id: 188937:MA_RS15570
uniprot id: P58868
names: Function
names: Similarity
names: Subunit
messages: Acts as a methyl group carrier between MtmB and MtbA.
messages: Belongs to the methylamine corrinoid protein family.
messages: Can form a complex with MtmB.

188937:MA RS05825
gene id: 188937:MA_RS05825
uniprot id: Q8TRQ7
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS01185
gene id: 188937:MA_RS01185
uniprot id: Q8TU54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

188937:MA RS05690
gene id: 188937:MA_RS05690
uniprot id: Q8TRS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

188937:MA RS23935
gene id: 188937:MA_RS23935
uniprot id: Q8THD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

188937:MA RS02880
gene id: 188937:MA_RS02880
uniprot id: Q8TT89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

188937:MA RS22005
gene id: 188937:MA_RS22005
uniprot id: Q8TID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

188937:MA RS03400
gene id: 188937:MA_RS03400
uniprot id: Q8TSZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

188937:MA RS07965
gene id: 188937:MA_RS07965
uniprot id: Q8TH29
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS24005
gene id: 188937:MA_RS24005
uniprot id: Q8THB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

188937:MA RS05600
gene id: 188937:MA_RS05600
uniprot id: Q8TRU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

188937:MA RS03030
gene id: 188937:MA_RS03030
uniprot id: Q8TT60
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

188937:MA RS00985
gene id: 188937:MA_RS00985
uniprot id: Q8TU91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

188937:MA RS19610
gene id: 188937:MA_RS19610
uniprot id: Q8TJL8
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS21400
gene id: 188937:MA_RS21400
uniprot id: Q9HHA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

188937:MA RS15690
gene id: 188937:MA_RS15690
uniprot id: Q8TLP2
names: Similarity
messages: Belongs to the TrpC family.

188937:MA RS01465
gene id: 188937:MA_RS01465
uniprot id: Q8TTZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

188937:MA RS07515
gene id: 188937:MA_RS07515
uniprot id: Q8TQU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

188937:MA RS22015
gene id: 188937:MA_RS22015
uniprot id: Q8TID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

188937:MA RS08365
gene id: 188937:MA_RS08365
uniprot id: Q8TQD4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Does not catalyze the conversion of O-acetyl-L-homoserine into threonine.
messages: Homotrimer.
messages: The N-terminal 41 amino acids are required for activity.

188937:MA RS23690
gene id: 188937:MA_RS23690
uniprot id: Q8THH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

188937:MA RS23835
gene id: 188937:MA_RS23835
uniprot id: Q8THE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS01950
gene id: 188937:MA_RS01950
uniprot id: Q8TTQ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

188937:MA RS23955
gene id: 188937:MA_RS23955
uniprot id: Q8THC7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

188937:MA RS21805
gene id: 188937:MA_RS21805
uniprot id: Q8TIH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

188937:MA RS08235
gene id: 188937:MA_RS08235
uniprot id: Q8TQG0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

188937:MA RS21335
gene id: 188937:MA_RS21335
uniprot id: Q8TIQ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

188937:MA RS07635
gene id: 188937:MA_RS07635
uniprot id: Q8TQR9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

188937:MA RS10730
gene id: 188937:MA_RS10730
uniprot id: Q8TP54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

188937:MA RS19180
gene id: 188937:MA_RS19180
uniprot id: Q8TJU7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

188937:MA RS15370
gene id: 188937:MA_RS15370
uniprot id: Q8TLU2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

188937:MA RS00685
gene id: 188937:MA_RS00685
uniprot id: Q8TUD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

188937:MA RS10005
gene id: 188937:MA_RS10005
uniprot id: Q8TPJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

188937:MA RS05155
gene id: 188937:MA_RS05155
uniprot id: Q8TS20
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS17375
gene id: 188937:MA_RS17375
uniprot id: Q8TH54
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

188937:MA RS18005
gene id: 188937:MA_RS18005
uniprot id: Q8TKF9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

188937:MA RS11800
gene id: 188937:MA_RS11800
uniprot id: Q8TNL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS17450
gene id: 188937:MA_RS17450
uniprot id: Q8TKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

188937:MA RS00990
gene id: 188937:MA_RS00990
uniprot id: Q8TU90
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

188937:MA RS10415
gene id: 188937:MA_RS10415
uniprot id: Q8TPB3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

188937:MA RS13050
gene id: 188937:MA_RS13050
uniprot id: Q8TMY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

188937:MA RS19125
gene id: 188937:MA_RS19125
uniprot id: Q8TJV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

188937:MA RS00010
gene id: 188937:MA_RS00010
uniprot id: Q8TUR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

188937:MA RS20155
gene id: 188937:MA_RS20155
uniprot id: Q8TJC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity).

188937:MA RS07685
gene id: 188937:MA_RS07685
uniprot id: Q8TQQ9
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS13260
gene id: 188937:MA_RS13260
uniprot id: Q8TMV1
names: Subcellular Location Annotation
messages: Membrane

188937:MA RS00170
gene id: 188937:MA_RS00170
uniprot id: Q8TUN3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

188937:MA RS11125
gene id: 188937:MA_RS11125
uniprot id: Q8TNY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

188937:MA RS05325
gene id: 188937:MA_RS05325
uniprot id: P58837
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

188937:MA RS00610
gene id: 188937:MA_RS00610
uniprot id: Q8TUF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

188937:MA RS20350
gene id: 188937:MA_RS20350
uniprot id: Q8TJ89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

188937:MA RS14645
gene id: 188937:MA_RS14645
uniprot id: Q8TH39
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

188937:MA RS22805
gene id: 188937:MA_RS22805
uniprot id: Q8THZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

188937:MA RS03245
gene id: 188937:MA_RS03245
uniprot id: Q8TT22
names: Subcellular Location Annotation
messages: Membrane