186541:CIEBOVp4
gene id: 186541:CIEBOVp4
uniprot id: B8XCN9
uniprot id: B8XCP0
uniprot id: B8XCP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviruses glycoprotein family.
messages: Secreted

186541:CIEBOVp3
gene id: 186541:CIEBOVp3
uniprot id: B8XCN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae matrix protein VP40 family.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Host cell membrane
messages: Host endomembrane system
messages: Host late endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway.
messages: Virion membrane

186541:CIEBOVp5
gene id: 186541:CIEBOVp5
uniprot id: B8XCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae transcriptional activator VP30 family.
messages: Cytoplasm
messages: Host cytoplasm
messages: Virion

186541:CIEBOVp2
gene id: 186541:CIEBOVp2
uniprot id: B8XCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae polymerase cofactor VP35 family.
messages: Cytoplasm
messages: Host cytoplasm
messages: Virion

186541:CIEBOVp1
gene id: 186541:CIEBOVp1
uniprot id: B8XCN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the filoviruses nucleoprotein family.
messages: Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid.
messages: Host cytoplasm
messages: Virion

186541:CIEBOVp6
gene id: 186541:CIEBOVp6
uniprot id: B8XCP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae membrane-associated protein VP24 family.
messages: Cell membrane
messages: Endomembrane system
messages: Host cell membrane
messages: Host endomembrane system
messages: May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
messages: Membrane
messages: Virion membrane

186541:CIEBOVp7
gene id: 186541:CIEBOVp7
uniprot id: B8XCP4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Host cytoplasm
messages: RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
messages: RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
messages: Virion