186540:SEVgp4
gene id: 186540:SEVgp4
uniprot id: A0A0E3KN50
uniprot id: A0A0E3NBA8
uniprot id: A0A2U8KL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviruses glycoprotein family.
messages: Secreted

186540:SEVgp2
gene id: 186540:SEVgp2
uniprot id: A0A0E3N5D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the filoviridae polymerase cofactor VP35 family.
messages: Cytoplasm
messages: Homooligomer.
messages: Host cytoplasm
messages: Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
messages: Virion

186540:SEVgp5
gene id: 186540:SEVgp5
uniprot id: A0A0E3NAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae transcriptional activator VP30 family.
messages: Cytoplasm
messages: Host cytoplasm
messages: Virion

186540:SEVgp1
gene id: 186540:SEVgp1
uniprot id: A0A2U8KL52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the filoviruses nucleoprotein family.
messages: Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid.
messages: Host cytoplasm
messages: Virion

186540:SEVgp6
gene id: 186540:SEVgp6
uniprot id: R4QUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae membrane-associated protein VP24 family.
messages: Cell membrane
messages: Endomembrane system
messages: Host cell membrane
messages: Host endomembrane system
messages: May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
messages: Membrane
messages: Virion membrane

186540:SEVgp3
gene id: 186540:SEVgp3
uniprot id: B0LPL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the filoviridae matrix protein VP40 family.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Host cell membrane
messages: Host endomembrane system
messages: Host late endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway.
messages: Virion membrane

186540:SEVgp7
gene id: 186540:SEVgp7
uniprot id: A0A0E3H7J9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Host cytoplasm
messages: RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
messages: RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
messages: Virion