171282:EXC45 RS02095
gene id: 171282:EXC45_RS02095
uniprot id: A0A449B6L7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

171282:EXC45 RS02280
gene id: 171282:EXC45_RS02280
uniprot id: A0A449B6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

171282:EXC45 RS01245
gene id: 171282:EXC45_RS01245
uniprot id: A0A449B657
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

171282:EXC45 RS01765
gene id: 171282:EXC45_RS01765
uniprot id: A0A449B6Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

171282:EXC45 RS01435
gene id: 171282:EXC45_RS01435
uniprot id: A0A449B695
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

171282:EXC45 RS01180
gene id: 171282:EXC45_RS01180
uniprot id: A0A449B6D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

171282:EXC45 RS01630
gene id: 171282:EXC45_RS01630
uniprot id: A0A449B6C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

171282:EXC45 RS00490
gene id: 171282:EXC45_RS00490
uniprot id: A0A449B5U0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

171282:EXC45 RS03110
gene id: 171282:EXC45_RS03110
uniprot id: A0A449B785
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

171282:EXC45 RS01345
gene id: 171282:EXC45_RS01345
uniprot id: A0A449B670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

171282:EXC45 RS01135
gene id: 171282:EXC45_RS01135
uniprot id: A0A449B665
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

171282:EXC45 RS03300
gene id: 171282:EXC45_RS03300
uniprot id: A0A449B7C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

171282:EXC45 RS03220
gene id: 171282:EXC45_RS03220
uniprot id: A0A449B7A7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

171282:EXC45 RS01340
gene id: 171282:EXC45_RS01340
uniprot id: A0A449B6A3
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS01035
gene id: 171282:EXC45_RS01035
uniprot id: A0A449B616
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

171282:EXC45 RS01365
gene id: 171282:EXC45_RS01365
uniprot id: A0A449B687
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

171282:EXC45 RS01325
gene id: 171282:EXC45_RS01325
uniprot id: A0A449B678
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

171282:EXC45 RS03555
gene id: 171282:EXC45_RS03555
uniprot id: A0A449B7I0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

171282:EXC45 RS01215
gene id: 171282:EXC45_RS01215
uniprot id: A0A449B6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS02560
gene id: 171282:EXC45_RS02560
uniprot id: A0A449B6Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS01910
gene id: 171282:EXC45_RS01910
uniprot id: A0A449B6N5
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

171282:EXC45 RS02460
gene id: 171282:EXC45_RS02460
uniprot id: A0A449B6X2
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS01025
gene id: 171282:EXC45_RS01025
uniprot id: A0A449B650
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

171282:EXC45 RS02650
gene id: 171282:EXC45_RS02650
uniprot id: A0A449B6X8
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS03540
gene id: 171282:EXC45_RS03540
uniprot id: A0A449B7H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

171282:EXC45 RS00785
gene id: 171282:EXC45_RS00785
uniprot id: A0A449B5Z7
names: Similarity
messages: Belongs to the XFP family.

171282:EXC45 RS03350
gene id: 171282:EXC45_RS03350
uniprot id: A0A449B7D5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

171282:EXC45 RS03320
gene id: 171282:EXC45_RS03320
uniprot id: A0A449B7C9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

171282:EXC45 RS00970
gene id: 171282:EXC45_RS00970
uniprot id: A0A449B690
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

171282:EXC45 RS00135
gene id: 171282:EXC45_RS00135
uniprot id: A0A449B5M6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

171282:EXC45 RS01690
gene id: 171282:EXC45_RS01690
uniprot id: A0A449B6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

171282:EXC45 RS00385
gene id: 171282:EXC45_RS00385
uniprot id: A0A449B5T3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

171282:EXC45 RS03625
gene id: 171282:EXC45_RS03625
uniprot id: A0A449B7H7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

171282:EXC45 RS03605
gene id: 171282:EXC45_RS03605
uniprot id: A0A449B7J0
names: Similarity
messages: Belongs to the peptidase M13 family.

171282:EXC45 RS01395
gene id: 171282:EXC45_RS01395
uniprot id: A0A449B682
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

171282:EXC45 RS02625
gene id: 171282:EXC45_RS02625
uniprot id: A0A449B6X4
names: Similarity
messages: Belongs to the IMPACT family.

171282:EXC45 RS02930
gene id: 171282:EXC45_RS02930
uniprot id: A0A449B751
names: Similarity
messages: Belongs to the pyruvate kinase family.

171282:EXC45 RS02780
gene id: 171282:EXC45_RS02780
uniprot id: A0A449B730
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

171282:EXC45 RS03075
gene id: 171282:EXC45_RS03075
uniprot id: A0A449B774
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

171282:EXC45 RS01380
gene id: 171282:EXC45_RS01380
uniprot id: A0A449B686
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

171282:EXC45 RS02910
gene id: 171282:EXC45_RS02910
uniprot id: A0A449B750
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

171282:EXC45 RS00910
gene id: 171282:EXC45_RS00910
uniprot id: A0A449B614
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS03265
gene id: 171282:EXC45_RS03265
uniprot id: A0A449B7B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS03525
gene id: 171282:EXC45_RS03525
uniprot id: A0A449B7F7
names: Similarity
messages: Belongs to the peptidase A8 family.

171282:EXC45 RS03145
gene id: 171282:EXC45_RS03145
uniprot id: A0A449B792
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

171282:EXC45 RS00045
gene id: 171282:EXC45_RS00045
uniprot id: A0A449B5H2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

171282:EXC45 RS02515
gene id: 171282:EXC45_RS02515
uniprot id: A0A449B6W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

171282:EXC45 RS01575
gene id: 171282:EXC45_RS01575
uniprot id: A0A449B6B0
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

171282:EXC45 RS00890
gene id: 171282:EXC45_RS00890
uniprot id: A0A449B625
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

171282:EXC45 RS01635
gene id: 171282:EXC45_RS01635
uniprot id: A0A449B6H8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS03130
gene id: 171282:EXC45_RS03130
uniprot id: A0A449B791
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

171282:EXC45 RS03390
gene id: 171282:EXC45_RS03390
uniprot id: A0A449B7E8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00715
gene id: 171282:EXC45_RS00715
uniprot id: A0A449B5V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

171282:EXC45 RS03420
gene id: 171282:EXC45_RS03420
uniprot id: A0A449B7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS03375
gene id: 171282:EXC45_RS03375
uniprot id: A0A449B7D9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

171282:EXC45 RS01935
gene id: 171282:EXC45_RS01935
uniprot id: A0A449B6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS03585
gene id: 171282:EXC45_RS03585
uniprot id: A0A449B7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

171282:EXC45 RS03135
gene id: 171282:EXC45_RS03135
uniprot id: A0A449B790
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

171282:EXC45 RS01845
gene id: 171282:EXC45_RS01845
uniprot id: A0A449B6H7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

171282:EXC45 RS01250
gene id: 171282:EXC45_RS01250
uniprot id: A0A449B6B6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

171282:EXC45 RS00240
gene id: 171282:EXC45_RS00240
uniprot id: A0A449B5P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

171282:EXC45 RS01270
gene id: 171282:EXC45_RS01270
uniprot id: A0A449B669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

171282:EXC45 RS01940
gene id: 171282:EXC45_RS01940
uniprot id: A0A449B6N8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

171282:EXC45 RS01595
gene id: 171282:EXC45_RS01595
uniprot id: A0A449B6H0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS02950
gene id: 171282:EXC45_RS02950
uniprot id: A0A449B756
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

171282:EXC45 RS02850
gene id: 171282:EXC45_RS02850
uniprot id: A0A449B740
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

171282:EXC45 RS03675
gene id: 171282:EXC45_RS03675
uniprot id: A0A449B7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

171282:EXC45 RS00905
gene id: 171282:EXC45_RS00905
uniprot id: A0A449B636
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

171282:EXC45 RS03560
gene id: 171282:EXC45_RS03560
uniprot id: A0A449B7H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

171282:EXC45 RS02470
gene id: 171282:EXC45_RS02470
uniprot id: A0A449B6U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

171282:EXC45 RS00685
gene id: 171282:EXC45_RS00685
uniprot id: A0A449B5Y8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

171282:EXC45 RS02120
gene id: 171282:EXC45_RS02120
uniprot id: A0A449B6S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

171282:EXC45 RS02075
gene id: 171282:EXC45_RS02075
uniprot id: A0A449B6M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS01915
gene id: 171282:EXC45_RS01915
uniprot id: A0A449B6I5
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

171282:EXC45 RS01805
gene id: 171282:EXC45_RS01805
uniprot id: A0A449B6G5
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

171282:EXC45 RS02875
gene id: 171282:EXC45_RS02875
uniprot id: A0A449B741
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

171282:EXC45 RS02915
gene id: 171282:EXC45_RS02915
uniprot id: A0A449B752
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

171282:EXC45 RS03695
gene id: 171282:EXC45_RS03695
uniprot id: A0A449B7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

171282:EXC45 RS00435
gene id: 171282:EXC45_RS00435
uniprot id: A0A449B5U3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

171282:EXC45 RS02410
gene id: 171282:EXC45_RS02410
uniprot id: A0A449B6W1
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS03530
gene id: 171282:EXC45_RS03530
uniprot id: A0A449B7F9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

171282:EXC45 RS01660
gene id: 171282:EXC45_RS01660
uniprot id: A0A449B6D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

171282:EXC45 RS00985
gene id: 171282:EXC45_RS00985
uniprot id: A0A449B613
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

171282:EXC45 RS03680
gene id: 171282:EXC45_RS03680
uniprot id: A0A449B7I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

171282:EXC45 RS01640
gene id: 171282:EXC45_RS01640
uniprot id: A0A449B6D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

171282:EXC45 RS00445
gene id: 171282:EXC45_RS00445
uniprot id: A0A449B5Q6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS02605
gene id: 171282:EXC45_RS02605
uniprot id: A0A449B6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

171282:EXC45 RS01280
gene id: 171282:EXC45_RS01280
uniprot id: A0A449B6F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS02555
gene id: 171282:EXC45_RS02555
uniprot id: A0A449B708
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

171282:EXC45 RS03690
gene id: 171282:EXC45_RS03690
uniprot id: A0A449B7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

171282:EXC45 RS03700
gene id: 171282:EXC45_RS03700
uniprot id: A0A449B7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

171282:EXC45 RS02620
gene id: 171282:EXC45_RS02620
uniprot id: A0A449B6X6
names: Similarity
messages: Belongs to the peptidase M17 family.

171282:EXC45 RS03000
gene id: 171282:EXC45_RS03000
uniprot id: A0A449B767
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

171282:EXC45 RS03400
gene id: 171282:EXC45_RS03400
uniprot id: A0A449B7E4
names: Similarity
messages: Belongs to the MG185/MG260 family.

171282:EXC45 RS00320
gene id: 171282:EXC45_RS00320
uniprot id: A0A449B5Q9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00290
gene id: 171282:EXC45_RS00290
uniprot id: A0A449B5Q3
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS00885
gene id: 171282:EXC45_RS00885
uniprot id: A0A449B5Z3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00680
gene id: 171282:EXC45_RS00680
uniprot id: A0A449B5V0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

171282:EXC45 RS01255
gene id: 171282:EXC45_RS01255
uniprot id: A0A449B664
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

171282:EXC45 RS01160
gene id: 171282:EXC45_RS01160
uniprot id: A0A449B639
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

171282:EXC45 RS02255
gene id: 171282:EXC45_RS02255
uniprot id: A0A449B6Q2
names: Similarity
messages: Belongs to the thioredoxin family.

171282:EXC45 RS01885
gene id: 171282:EXC45_RS01885
uniprot id: A0A449B6M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

171282:EXC45 RS01725
gene id: 171282:EXC45_RS01725
uniprot id: A0A449B6E5
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.

171282:EXC45 RS02905
gene id: 171282:EXC45_RS02905
uniprot id: A0A449B754
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

171282:EXC45 RS01590
gene id: 171282:EXC45_RS01590
uniprot id: A0A449B6C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS00470
gene id: 171282:EXC45_RS00470
uniprot id: A0A449B5U1
names: Subcellular Location Annotation
messages: cytosol

171282:EXC45 RS02405
gene id: 171282:EXC45_RS02405
uniprot id: A0A449B705
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

171282:EXC45 RS01930
gene id: 171282:EXC45_RS01930
uniprot id: A0A449B6I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS01855
gene id: 171282:EXC45_RS01855
uniprot id: A0A449B6H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

171282:EXC45 RS02325
gene id: 171282:EXC45_RS02325
uniprot id: A0A449B6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS03385
gene id: 171282:EXC45_RS03385
uniprot id: A0A449B7E3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

171282:EXC45 RS03355
gene id: 171282:EXC45_RS03355
uniprot id: A0A449B7F1
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

171282:EXC45 RS01370
gene id: 171282:EXC45_RS01370
uniprot id: A0A449B6D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

171282:EXC45 RS02570
gene id: 171282:EXC45_RS02570
uniprot id: A0A449B6W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

171282:EXC45 RS03155
gene id: 171282:EXC45_RS03155
uniprot id: A0A449B793
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

171282:EXC45 RS02485
gene id: 171282:EXC45_RS02485
uniprot id: A0A449B6V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

171282:EXC45 RS02995
gene id: 171282:EXC45_RS02995
uniprot id: A0A449B762
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

171282:EXC45 RS02590
gene id: 171282:EXC45_RS02590
uniprot id: A0A449B701
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

171282:EXC45 RS02290
gene id: 171282:EXC45_RS02290
uniprot id: A0A449B6R8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00950
gene id: 171282:EXC45_RS00950
uniprot id: A0A449B5Z5
names: Subunit
messages: Monomer.

171282:EXC45 RS00895
gene id: 171282:EXC45_RS00895
uniprot id: A0A449B5Z1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

171282:EXC45 RS00345
gene id: 171282:EXC45_RS00345
uniprot id: A0A449B5N5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

171282:EXC45 RS02110
gene id: 171282:EXC45_RS02110
uniprot id: A0A449B6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

171282:EXC45 RS03465
gene id: 171282:EXC45_RS03465
uniprot id: A0A449B7H2
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

171282:EXC45 RS02360
gene id: 171282:EXC45_RS02360
uniprot id: A0A449B6V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

171282:EXC45 RS00220
gene id: 171282:EXC45_RS00220
uniprot id: A0A449B5L4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

171282:EXC45 RS03325
gene id: 171282:EXC45_RS03325
uniprot id: A0A449B7D0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

171282:EXC45 RS02270
gene id: 171282:EXC45_RS02270
uniprot id: A0A449B6R0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

171282:EXC45 RS01275
gene id: 171282:EXC45_RS01275
uniprot id: A0A449B662
names: Subcellular Location Annotation
messages: Cytoplasm

171282:EXC45 RS03730
gene id: 171282:EXC45_RS03730
uniprot id: A0A449B7J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

171282:EXC45 RS00990
gene id: 171282:EXC45_RS00990
uniprot id: A0A449B648
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

171282:EXC45 RS03825
gene id: 171282:EXC45_RS03825
uniprot id: A0A449B7M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

171282:EXC45 RS01865
gene id: 171282:EXC45_RS01865
uniprot id: A0A449B6S3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

171282:EXC45 RS01445
gene id: 171282:EXC45_RS01445
uniprot id: A0A449B6C3
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

171282:EXC45 RS03245
gene id: 171282:EXC45_RS03245
uniprot id: A0A449B7B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

171282:EXC45 RS03040
gene id: 171282:EXC45_RS03040
uniprot id: A0A449B775
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

171282:EXC45 RS03120
gene id: 171282:EXC45_RS03120
uniprot id: A0A449B783
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

171282:EXC45 RS01810
gene id: 171282:EXC45_RS01810
uniprot id: A0A449B6G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

171282:EXC45 RS00125
gene id: 171282:EXC45_RS00125
uniprot id: A0A449B5J4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS01320
gene id: 171282:EXC45_RS01320
uniprot id: A0A449B6C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00660
gene id: 171282:EXC45_RS00660
uniprot id: A0A449B5U5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

171282:EXC45 RS01165
gene id: 171282:EXC45_RS01165
uniprot id: A0A449B694
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

171282:EXC45 RS01850
gene id: 171282:EXC45_RS01850
uniprot id: A0A449B6M5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

171282:EXC45 RS00280
gene id: 171282:EXC45_RS00280
uniprot id: A0A449B5M1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

171282:EXC45 RS02765
gene id: 171282:EXC45_RS02765
uniprot id: A0A449B723
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

171282:EXC45 RS00235
gene id: 171282:EXC45_RS00235
uniprot id: A0A449B5P9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

171282:EXC45 RS00430
gene id: 171282:EXC45_RS00430
uniprot id: A0A449B5Q1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

171282:EXC45 RS01430
gene id: 171282:EXC45_RS01430
uniprot id: A0A449B696
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

171282:EXC45 RS03805
gene id: 171282:EXC45_RS03805
uniprot id: A0A449B7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

171282:EXC45 RS03365
gene id: 171282:EXC45_RS03365
uniprot id: A0A449B7D6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

171282:EXC45 RS02835
gene id: 171282:EXC45_RS02835
uniprot id: A0A449B748
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

171282:EXC45 RS03115
gene id: 171282:EXC45_RS03115
uniprot id: A0A449B799
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

171282:EXC45 RS00205
gene id: 171282:EXC45_RS00205
uniprot id: A0A449B5L0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

171282:EXC45 RS02205
gene id: 171282:EXC45_RS02205
uniprot id: A0A449B6Y9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

171282:EXC45 RS02440
gene id: 171282:EXC45_RS02440
uniprot id: A0A449B6Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

171282:EXC45 RS01775
gene id: 171282:EXC45_RS01775
uniprot id: A0A449B6F5
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

171282:EXC45 RS01905
gene id: 171282:EXC45_RS01905
uniprot id: A0A449B6J0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

171282:EXC45 RS00285
gene id: 171282:EXC45_RS00285
uniprot id: A0A449B5R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

171282:EXC45 RS01730
gene id: 171282:EXC45_RS01730
uniprot id: A0A449B6E4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

171282:EXC45 RS03665
gene id: 171282:EXC45_RS03665
uniprot id: A0A449B7I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

171282:EXC45 RS01800
gene id: 171282:EXC45_RS01800
uniprot id: A0A449B6L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

171282:EXC45 RS00150
gene id: 171282:EXC45_RS00150
uniprot id: A0A449B5T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

171282:EXC45 RS01390
gene id: 171282:EXC45_RS01390
uniprot id: A0A449B6B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

171282:EXC45 RS01655
gene id: 171282:EXC45_RS01655
uniprot id: A0A449B6D7
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.

171282:EXC45 RS01315
gene id: 171282:EXC45_RS01315
uniprot id: A0A449B676
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS03670
gene id: 171282:EXC45_RS03670
uniprot id: A0A449B7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

171282:EXC45 RS00880
gene id: 171282:EXC45_RS00880
uniprot id: A0A449B5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

171282:EXC45 RS02565
gene id: 171282:EXC45_RS02565
uniprot id: A0A449B6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

171282:EXC45 RS02215
gene id: 171282:EXC45_RS02215
uniprot id: A0A449B6P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

171282:EXC45 RS00130
gene id: 171282:EXC45_RS00130
uniprot id: A0A449B5J1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00340
gene id: 171282:EXC45_RS00340
uniprot id: A0A449B5R1
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS02150
gene id: 171282:EXC45_RS02150
uniprot id: A0A449B6N0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS00420
gene id: 171282:EXC45_RS00420
uniprot id: A0A449B5S8
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

171282:EXC45 RS02580
gene id: 171282:EXC45_RS02580
uniprot id: A0A449B6X1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS01860
gene id: 171282:EXC45_RS01860
uniprot id: A0A449B6H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

171282:EXC45 RS00800
gene id: 171282:EXC45_RS00800
uniprot id: A0A449B622
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

171282:EXC45 RS00925
gene id: 171282:EXC45_RS00925
uniprot id: A0A449B635
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

171282:EXC45 RS02285
gene id: 171282:EXC45_RS02285
uniprot id: A0A449B6R2
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS01010
gene id: 171282:EXC45_RS01010
uniprot id: A0A449B630
names: Similarity
messages: Belongs to the AAA ATPase family.

171282:EXC45 RS02575
gene id: 171282:EXC45_RS02575
uniprot id: A0A449B700
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

171282:EXC45 RS03600
gene id: 171282:EXC45_RS03600
uniprot id: A0A449B7H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

171282:EXC45 RS02755
gene id: 171282:EXC45_RS02755
uniprot id: A0A449B722
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

171282:EXC45 RS01425
gene id: 171282:EXC45_RS01425
uniprot id: A0A449B6E0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

171282:EXC45 RS01735
gene id: 171282:EXC45_RS01735
uniprot id: A0A449B6J5
names: Subcellular Location Annotation
messages: Cell membrane

171282:EXC45 RS01515
gene id: 171282:EXC45_RS01515
uniprot id: A0A449B6A1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

171282:EXC45 RS03045
gene id: 171282:EXC45_RS03045
uniprot id: A0A449B778
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

171282:EXC45 RS02730
gene id: 171282:EXC45_RS02730
uniprot id: A0A449B716
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

171282:EXC45 RS01170
gene id: 171282:EXC45_RS01170
uniprot id: A0A449B649
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS00965
gene id: 171282:EXC45_RS00965
uniprot id: A0A449B604
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

171282:EXC45 RS03640
gene id: 171282:EXC45_RS03640
uniprot id: A0A449B7J2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

171282:EXC45 RS02635
gene id: 171282:EXC45_RS02635
uniprot id: A0A449B6Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

171282:EXC45 RS02210
gene id: 171282:EXC45_RS02210
uniprot id: A0A449B6R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

171282:EXC45 RS02115
gene id: 171282:EXC45_RS02115
uniprot id: A0A449B6M3
names: Similarity
messages: Belongs to the HPrK/P family.

171282:EXC45 RS00995
gene id: 171282:EXC45_RS00995
uniprot id: A0A449B612
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

171282:EXC45 RS02080
gene id: 171282:EXC45_RS02080
uniprot id: A0A449B6M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS02920
gene id: 171282:EXC45_RS02920
uniprot id: A0A449B755
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

171282:EXC45 RS02945
gene id: 171282:EXC45_RS02945
uniprot id: A0A449B757
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS01285
gene id: 171282:EXC45_RS01285
uniprot id: A0A449B693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS00315
gene id: 171282:EXC45_RS00315
uniprot id: A0A449B5N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

171282:EXC45 RS00645
gene id: 171282:EXC45_RS00645
uniprot id: A0A449B5U9
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS02450
gene id: 171282:EXC45_RS02450
uniprot id: A0A449B6T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

171282:EXC45 RS00155
gene id: 171282:EXC45_RS00155
uniprot id: A0A449B5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

171282:EXC45 RS02370
gene id: 171282:EXC45_RS02370
uniprot id: A0A449B6S4
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS01040
gene id: 171282:EXC45_RS01040
uniprot id: A0A449B624
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

171282:EXC45 RS01125
gene id: 171282:EXC45_RS01125
uniprot id: A0A449B640
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

171282:EXC45 RS03190
gene id: 171282:EXC45_RS03190
uniprot id: A0A449B7A4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

171282:EXC45 RS01265
gene id: 171282:EXC45_RS01265
uniprot id: A0A449B6B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

171282:EXC45 RS01075
gene id: 171282:EXC45_RS01075
uniprot id: A0A449B620
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

171282:EXC45 RS02230
gene id: 171282:EXC45_RS02230
uniprot id: A0A449B6Q0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

171282:EXC45 RS01780
gene id: 171282:EXC45_RS01780
uniprot id: A0A449B6F4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

171282:EXC45 RS00180
gene id: 171282:EXC45_RS00180
uniprot id: A0A449B5N8
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS03545
gene id: 171282:EXC45_RS03545
uniprot id: A0A449B7G6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

171282:EXC45 RS02355
gene id: 171282:EXC45_RS02355
uniprot id: A0A449B702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

171282:EXC45 RS01130
gene id: 171282:EXC45_RS01130
uniprot id: A0A449B6C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

171282:EXC45 RS00325
gene id: 171282:EXC45_RS00325
uniprot id: A0A449B5N4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

171282:EXC45 RS02725
gene id: 171282:EXC45_RS02725
uniprot id: A0A449B715
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS01440
gene id: 171282:EXC45_RS01440
uniprot id: A0A449B6I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

171282:EXC45 RS01880
gene id: 171282:EXC45_RS01880
uniprot id: A0A449B6H1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

171282:EXC45 RS00455
gene id: 171282:EXC45_RS00455
uniprot id: A0A449B5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

171282:EXC45 RS01520
gene id: 171282:EXC45_RS01520
uniprot id: A0A449B6A0
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

171282:EXC45 RS03800
gene id: 171282:EXC45_RS03800
uniprot id: A0A449B7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

171282:EXC45 RS00720
gene id: 171282:EXC45_RS00720
uniprot id: A0A449B5Y5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

171282:EXC45 RS00740
gene id: 171282:EXC45_RS00740
uniprot id: A0A449B5X1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

171282:EXC45 RS03080
gene id: 171282:EXC45_RS03080
uniprot id: A0A449B780
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

171282:EXC45 RS01410
gene id: 171282:EXC45_RS01410
uniprot id: A0A449B689
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

171282:EXC45 RS00810
gene id: 171282:EXC45_RS00810
uniprot id: A0A449B5Y3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

171282:EXC45 RS01540
gene id: 171282:EXC45_RS01540
uniprot id: A0A449B6G1
names: Similarity
messages: Belongs to the ATPase gamma chain family.

171282:EXC45 RS00460
gene id: 171282:EXC45_RS00460
uniprot id: A0A449B5Q5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

171282:EXC45 RS03275
gene id: 171282:EXC45_RS03275
uniprot id: A0A449B7B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

171282:EXC45 RS01105
gene id: 171282:EXC45_RS01105
uniprot id: A0A449B627
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

171282:EXC45 RS02900
gene id: 171282:EXC45_RS02900
uniprot id: A0A449B746
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

171282:EXC45 RS00690
gene id: 171282:EXC45_RS00690
uniprot id: A0A449B5X9
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

171282:EXC45 RS00270
gene id: 171282:EXC45_RS00270
uniprot id: A0A449B5P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

171282:EXC45 RS03450
gene id: 171282:EXC45_RS03450
uniprot id: A0A449B7G0
names: Subcellular Location Annotation
messages: Membrane

171282:EXC45 RS00330
gene id: 171282:EXC45_RS00330
uniprot id: A0A449B5N0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

171282:EXC45 RS02775
gene id: 171282:EXC45_RS02775
uniprot id: A0A449B728
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

171282:EXC45 RS02425
gene id: 171282:EXC45_RS02425
uniprot id: A0A449B6Y7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

171282:EXC45 RS01675
gene id: 171282:EXC45_RS01675
uniprot id: A0A449B6D0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

171282:EXC45 RS00975
gene id: 171282:EXC45_RS00975
uniprot id: A0A449B643
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

171282:EXC45 RS03095
gene id: 171282:EXC45_RS03095
uniprot id: A0A449B784
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

171282:EXC45 RS01405
gene id: 171282:EXC45_RS01405
uniprot id: A0A449B6D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

171282:EXC45 RS02315
gene id: 171282:EXC45_RS02315
uniprot id: A0A449B6U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

171282:EXC45 RS01525
gene id: 171282:EXC45_RS01525
uniprot id: A0A449B6F9
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

171282:EXC45 RS02825
gene id: 171282:EXC45_RS02825
uniprot id: A0A449B734
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

171282:EXC45 RS03100
gene id: 171282:EXC45_RS03100
uniprot id: A0A449B787
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

171282:EXC45 RS03360
gene id: 171282:EXC45_RS03360
uniprot id: A0A449B7D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

171282:EXC45 RS03750
gene id: 171282:EXC45_RS03750
uniprot id: A0A449B7L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

171282:EXC45 RS02165
gene id: 171282:EXC45_RS02165
uniprot id: A0A449B6N7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

171282:EXC45 RS01335
gene id: 171282:EXC45_RS01335
uniprot id: A0A449B6G7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

171282:EXC45 RS02705
gene id: 171282:EXC45_RS02705
uniprot id: A0A449B719
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

171282:EXC45 RS03235
gene id: 171282:EXC45_RS03235
uniprot id: A0A449B7B5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

171282:EXC45 RS02940
gene id: 171282:EXC45_RS02940
uniprot id: A0A449B769
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

171282:EXC45 RS02785
gene id: 171282:EXC45_RS02785
uniprot id: A0A449B726
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

171282:EXC45 RS03090
gene id: 171282:EXC45_RS03090
uniprot id: A0A449B786
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

171282:EXC45 RS02645
gene id: 171282:EXC45_RS02645
uniprot id: A0A449B704
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171282:EXC45 RS03105
gene id: 171282:EXC45_RS03105
uniprot id: A0A449B782
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

171282:EXC45 RS01875
gene id: 171282:EXC45_RS01875
uniprot id: A0A449B6H5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

171282:EXC45 RS02870
gene id: 171282:EXC45_RS02870
uniprot id: A0A449B742
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

171282:EXC45 RS01785
gene id: 171282:EXC45_RS01785
uniprot id: A0A449B6K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

171282:EXC45 RS03225
gene id: 171282:EXC45_RS03225
uniprot id: A0A449B7A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

171282:EXC45 RS02615
gene id: 171282:EXC45_RS02615
uniprot id: A0A449B6Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

171282:EXC45 RS03150
gene id: 171282:EXC45_RS03150
uniprot id: A0A449B794
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

171282:EXC45 RS03415
gene id: 171282:EXC45_RS03415
uniprot id: A0A449B7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171282:EXC45 RS02880
gene id: 171282:EXC45_RS02880
uniprot id: A0A449B743
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

171282:EXC45 RS02130
gene id: 171282:EXC45_RS02130
uniprot id: A0A449B6N6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

171282:EXC45 RS03055
gene id: 171282:EXC45_RS03055
uniprot id: A0A449B772
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

171282:EXC45 RS02720
gene id: 171282:EXC45_RS02720
uniprot id: A0A449B718
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.