1653476:THC RS03245
gene id: 1653476:THC_RS03245
uniprot id: A0A0U4W1Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1653476:THC RS06250
gene id: 1653476:THC_RS06250
uniprot id: A0A0U5B0Q2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS02875
gene id: 1653476:THC_RS02875
uniprot id: A0A0U5B4I9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1653476:THC RS01610
gene id: 1653476:THC_RS01610
uniprot id: A0A0U5ATZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1653476:THC RS04005
gene id: 1653476:THC_RS04005
uniprot id: A0A0U5B554
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1653476:THC RS06610
gene id: 1653476:THC_RS06610
uniprot id: A0A0U5AYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1653476:THC RS03380
gene id: 1653476:THC_RS03380
uniprot id: A0A0U5AGF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1653476:THC RS02820
gene id: 1653476:THC_RS02820
uniprot id: A0A0U5ALR8
names: Subcellular Location Annotation
messages: Cytoplasm

1653476:THC RS07010
gene id: 1653476:THC_RS07010
uniprot id: A0A0U4W3V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1653476:THC RS00525
gene id: 1653476:THC_RS00525
uniprot id: A0A0U5B3C7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1653476:THC RS05405
gene id: 1653476:THC_RS05405
uniprot id: A0A0U4N2G7
names: Similarity
messages: Belongs to the LOG family.

1653476:THC RS01620
gene id: 1653476:THC_RS01620
uniprot id: A0A0U4W0M6
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1653476:THC RS03070
gene id: 1653476:THC_RS03070
uniprot id: A0A0U5AUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1653476:THC RS03060
gene id: 1653476:THC_RS03060
uniprot id: A0A0U4N1B8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1653476:THC RS06485
gene id: 1653476:THC_RS06485
uniprot id: A0A0U4N2Y7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1653476:THC RS01865
gene id: 1653476:THC_RS01865
uniprot id: A0A0U4W0T6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1653476:THC RS00980
gene id: 1653476:THC_RS00980
uniprot id: A0A0U4W0A2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1653476:THC RS00890
gene id: 1653476:THC_RS00890
uniprot id: A0A0U5ATK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1653476:THC RS00810
gene id: 1653476:THC_RS00810
uniprot id: A0A0U5BVD9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1653476:THC RS04825
gene id: 1653476:THC_RS04825
uniprot id: A0A0U5AVP8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1653476:THC RS05445
gene id: 1653476:THC_RS05445
uniprot id: A0A0U5AXT7
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00700
gene id: 1653476:THC_RS00700
uniprot id: A0A0U5AVY9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1653476:THC RS04555
gene id: 1653476:THC_RS04555
uniprot id: A0A0U5BX82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1653476:THC RS04755
gene id: 1653476:THC_RS04755
uniprot id: A0A0U4W2N5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1653476:THC RS02255
gene id: 1653476:THC_RS02255
uniprot id: A0A0U5BW46
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1653476:THC RS00800
gene id: 1653476:THC_RS00800
uniprot id: A0A0U5AEY5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1653476:THC RS08495
gene id: 1653476:THC_RS08495
uniprot id: A0A0U4W4S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1653476:THC RS08220
gene id: 1653476:THC_RS08220
uniprot id: A0A0U4N3Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1653476:THC RS00585
gene id: 1653476:THC_RS00585
uniprot id: A0A0U4W026
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1653476:THC RS04040
gene id: 1653476:THC_RS04040
uniprot id: A0A0U4N1U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1653476:THC RS00940
gene id: 1653476:THC_RS00940
uniprot id: A0A0U5AL21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1653476:THC RS04695
gene id: 1653476:THC_RS04695
uniprot id: A0A0U5B5H3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1653476:THC RS05910
gene id: 1653476:THC_RS05910
uniprot id: A0A0U4N2P9
names: Similarity
messages: Belongs to the asparagine synthetase family.

1653476:THC RS08310
gene id: 1653476:THC_RS08310
uniprot id: A0A0U5B1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1653476:THC RS07650
gene id: 1653476:THC_RS07650
uniprot id: A0A0U5AJ02
names: Similarity
messages: Belongs to the Ahb/Nir family.

1653476:THC RS01150
gene id: 1653476:THC_RS01150
uniprot id: A0A0U5AVS1
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1653476:THC RS08710
gene id: 1653476:THC_RS08710
uniprot id: A0A0U4N482
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS03990
gene id: 1653476:THC_RS03990
uniprot id: A0A0U4W293
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1653476:THC RS00325
gene id: 1653476:THC_RS00325
uniprot id: A0A0U5AT84
names: Similarity
messages: Belongs to the peptidase S16 family.

1653476:THC RS04190
gene id: 1653476:THC_RS04190
uniprot id: A0A0U5B587
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1653476:THC RS01430
gene id: 1653476:THC_RS01430
uniprot id: A0A0U5AFA9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04185
gene id: 1653476:THC_RS04185
uniprot id: A0A0U5AXR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1653476:THC RS06300
gene id: 1653476:THC_RS06300
uniprot id: A0A0U5AP08
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1653476:THC RS01910
gene id: 1653476:THC_RS01910
uniprot id: A0A0U5APM1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1653476:THC RS05480
gene id: 1653476:THC_RS05480
uniprot id: A0A0U5BXM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1653476:THC RS01465
gene id: 1653476:THC_RS01465
uniprot id: A0A0U4W0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1653476:THC RS00285
gene id: 1653476:THC_RS00285
uniprot id: A0A0U5B3A2
names: Similarity
messages: Belongs to the YggT family.

1653476:THC RS05765
gene id: 1653476:THC_RS05765
uniprot id: A0A0U4W362
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1653476:THC RS00945
gene id: 1653476:THC_RS00945
uniprot id: A0A0U5AF19
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

1653476:THC RS08165
gene id: 1653476:THC_RS08165
uniprot id: A0A0U4W4L2
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1653476:THC RS09530
gene id: 1653476:THC_RS09530
uniprot id: A0A0U5AYT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1653476:THC RS05915
gene id: 1653476:THC_RS05915
uniprot id: A0A0U5AI39
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1653476:THC RS06290
gene id: 1653476:THC_RS06290
uniprot id: A0A0U5B6B9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

1653476:THC RS07915
gene id: 1653476:THC_RS07915
uniprot id: A0A0U5B791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1653476:THC RS07985
gene id: 1653476:THC_RS07985
uniprot id: A0A0U5AZ41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1653476:THC RS03250
gene id: 1653476:THC_RS03250
uniprot id: A0A0U4W1P9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00475
gene id: 1653476:THC_RS00475
uniprot id: A0A0U4MZZ0
names: Similarity
messages: Belongs to the OprB family.

1653476:THC RS08360
gene id: 1653476:THC_RS08360
uniprot id: A0A0U5AJF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1653476:THC RS01270
gene id: 1653476:THC_RS01270
uniprot id: A0A0U5BVL8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1653476:THC RS06830
gene id: 1653476:THC_RS06830
uniprot id: A0A0U5B0Z9
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1653476:THC RS08390
gene id: 1653476:THC_RS08390
uniprot id: A0A0U5B1S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1653476:THC RS00450
gene id: 1653476:THC_RS00450
uniprot id: A0A0U5B3B5
names: Similarity
messages: Belongs to the UPF0751 family.

1653476:THC RS07880
gene id: 1653476:THC_RS07880
uniprot id: A0A0U5B1J4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1653476:THC RS04335
gene id: 1653476:THC_RS04335
uniprot id: A0A0U4W2F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1653476:THC RS06970
gene id: 1653476:THC_RS06970
uniprot id: A0A0U5BYA6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1653476:THC RS08180
gene id: 1653476:THC_RS08180
uniprot id: A0A0U5AZ72
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1653476:THC RS00655
gene id: 1653476:THC_RS00655
uniprot id: A0A0U5AEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1653476:THC RS03145
gene id: 1653476:THC_RS03145
uniprot id: A0A0U5BWL0
names: Similarity
messages: Belongs to the ETF-QO/FixC family.

1653476:THC RS00355
gene id: 1653476:THC_RS00355
uniprot id: A0A0U5AVC5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1653476:THC RS04045
gene id: 1653476:THC_RS04045
uniprot id: A0A0U5AGT8
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07420
gene id: 1653476:THC_RS07420
uniprot id: A0A0U4W439
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1653476:THC RS00190
gene id: 1653476:THC_RS00190
uniprot id: A0A0U4VZU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS08030
gene id: 1653476:THC_RS08030
uniprot id: A0A0U4N3V8
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1653476:THC RS04535
gene id: 1653476:THC_RS04535
uniprot id: A0A0U5AQX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS06975
gene id: 1653476:THC_RS06975
uniprot id: A0A0U4N382
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1653476:THC RS08435
gene id: 1653476:THC_RS08435
uniprot id: A0A0U5AQ12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1653476:THC RS00255
gene id: 1653476:THC_RS00255
uniprot id: A0A0U4VZU4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1653476:THC RS01415
gene id: 1653476:THC_RS01415
uniprot id: A0A0U5B3S9
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1653476:THC RS00245
gene id: 1653476:THC_RS00245
uniprot id: A0A0U5AT38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1653476:THC RS00425
gene id: 1653476:THC_RS00425
uniprot id: A0A0U4VZY9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

1653476:THC RS05960
gene id: 1653476:THC_RS05960
uniprot id: A0A0U5B657
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1653476:THC RS00360
gene id: 1653476:THC_RS00360
uniprot id: A0A0U5AVS9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1653476:THC RS01645
gene id: 1653476:THC_RS01645
uniprot id: A0A0U5AWH9
names: Similarity
messages: Belongs to the RemA family.

1653476:THC RS06720
gene id: 1653476:THC_RS06720
uniprot id: A0A0U5AIH8
names: Similarity
messages: Belongs to the hemerythrin family.

1653476:THC RS04310
gene id: 1653476:THC_RS04310
uniprot id: A0A0U5AH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1653476:THC RS01135
gene id: 1653476:THC_RS01135
uniprot id: A0A0U4W0E7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1653476:THC RS03190
gene id: 1653476:THC_RS03190
uniprot id: A0A0U5AX83
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04445
gene id: 1653476:THC_RS04445
uniprot id: A0A0U5AXU8
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1653476:THC RS06395
gene id: 1653476:THC_RS06395
uniprot id: A0A0U5ANJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1653476:THC RS08025
gene id: 1653476:THC_RS08025
uniprot id: A0A0U5BYT5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

1653476:THC RS06985
gene id: 1653476:THC_RS06985
uniprot id: A0A0U5AWM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1653476:THC RS01490
gene id: 1653476:THC_RS01490
uniprot id: A0A0U5AWE4
names: Similarity
messages: Belongs to the archease family.

1653476:THC RS08950
gene id: 1653476:THC_RS08950
uniprot id: A0A0U5AJS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1653476:THC RS01470
gene id: 1653476:THC_RS01470
uniprot id: A0A0U4W0K7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1653476:THC RS02300
gene id: 1653476:THC_RS02300
uniprot id: A0A0U5AWB4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1653476:THC RS07250
gene id: 1653476:THC_RS07250
uniprot id: A0A0U4W401
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1653476:THC RS07130
gene id: 1653476:THC_RS07130
uniprot id: A0A0U5APF4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1653476:THC RS07560
gene id: 1653476:THC_RS07560
uniprot id: A0A0U4W452
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1653476:THC RS04830
gene id: 1653476:THC_RS04830
uniprot id: A0A0U5AZZ9
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1653476:THC RS08420
gene id: 1653476:THC_RS08420
uniprot id: A0A0U5AZW2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1653476:THC RS08070
gene id: 1653476:THC_RS08070
uniprot id: A0A0U5AZ56
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS02840
gene id: 1653476:THC_RS02840
uniprot id: A0A0U5AYZ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS03170
gene id: 1653476:THC_RS03170
uniprot id: A0A0U4W1N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1653476:THC RS05460
gene id: 1653476:THC_RS05460
uniprot id: A0A0U5ARE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1653476:THC RS03350
gene id: 1653476:THC_RS03350
uniprot id: A0A0U4W1V3
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04820
gene id: 1653476:THC_RS04820
uniprot id: A0A0U5AHH8
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08260
gene id: 1653476:THC_RS08260
uniprot id: A0A0U5AZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1653476:THC RS03565
gene id: 1653476:THC_RS03565
uniprot id: A0A0U4W215
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03095
gene id: 1653476:THC_RS03095
uniprot id: A0A0U5AGA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1653476:THC RS05255
gene id: 1653476:THC_RS05255
uniprot id: A0A0U4W2X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1653476:THC RS02135
gene id: 1653476:THC_RS02135
uniprot id: A0A0U4W100
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1653476:THC RS05835
gene id: 1653476:THC_RS05835
uniprot id: A0A0U5AW65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

1653476:THC RS02710
gene id: 1653476:THC_RS02710
uniprot id: A0A0U5AWK4
names: Similarity
messages: Belongs to the sigma-54 factor family.

1653476:THC RS04725
gene id: 1653476:THC_RS04725
uniprot id: A0A0U5BXA7
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1653476:THC RS09260
gene id: 1653476:THC_RS09260
uniprot id: A0A0U5AP01
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1653476:THC RS00935
gene id: 1653476:THC_RS00935
uniprot id: A0A0U5AP29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

1653476:THC RS07685
gene id: 1653476:THC_RS07685
uniprot id: A0A0U5AJ23
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1653476:THC RS06020
gene id: 1653476:THC_RS06020
uniprot id: A0A0U4W3C0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1653476:THC RS02785
gene id: 1653476:THC_RS02785
uniprot id: A0A0U4W1D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1653476:THC RS08425
gene id: 1653476:THC_RS08425
uniprot id: A0A0U5B7I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1653476:THC RS08460
gene id: 1653476:THC_RS08460
uniprot id: A0A0U4N435
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1653476:THC RS03200
gene id: 1653476:THC_RS03200
uniprot id: A0A0U5AQB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1653476:THC RS02880
gene id: 1653476:THC_RS02880
uniprot id: A0A0U5AQ53
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1653476:THC RS04730
gene id: 1653476:THC_RS04730
uniprot id: A0A0U4N258
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1653476:THC RS06230
gene id: 1653476:THC_RS06230
uniprot id: A0A0U5BXY2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1653476:THC RS08240
gene id: 1653476:THC_RS08240
uniprot id: A0A0U4W4L8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1653476:THC RS08875
gene id: 1653476:THC_RS08875
uniprot id: A0A0U5APU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1653476:THC RS02270
gene id: 1653476:THC_RS02270
uniprot id: A0A0U5AUD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1653476:THC RS03635
gene id: 1653476:THC_RS03635
uniprot id: A0A0U5AGK0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1653476:THC RS06015
gene id: 1653476:THC_RS06015
uniprot id: A0A0U5AI41
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02845
gene id: 1653476:THC_RS02845
uniprot id: A0A0U4W1E7
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02935
gene id: 1653476:THC_RS02935
uniprot id: A0A0U5AG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1653476:THC RS02980
gene id: 1653476:THC_RS02980
uniprot id: A0A0U5BWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1653476:THC RS07360
gene id: 1653476:THC_RS07360
uniprot id: A0A0U5APJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1653476:THC RS06025
gene id: 1653476:THC_RS06025
uniprot id: A0A0U5AY39
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1653476:THC RS03400
gene id: 1653476:THC_RS03400
uniprot id: A0A0U5AGG3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06755
gene id: 1653476:THC_RS06755
uniprot id: A0A0U4W3P8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1653476:THC RS04950
gene id: 1653476:THC_RS04950
uniprot id: A0A0U5AY32
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

1653476:THC RS02385
gene id: 1653476:THC_RS02385
uniprot id: A0A0U5AWT7
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS06775
gene id: 1653476:THC_RS06775
uniprot id: A0A0U5AYG9
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1653476:THC RS08225
gene id: 1653476:THC_RS08225
uniprot id: A0A0U5AJE6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1653476:THC RS06030
gene id: 1653476:THC_RS06030
uniprot id: A0A0U5AYN2
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02660
gene id: 1653476:THC_RS02660
uniprot id: A0A0U5ALN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1653476:THC RS01285
gene id: 1653476:THC_RS01285
uniprot id: A0A0U5ATS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1653476:THC RS00735
gene id: 1653476:THC_RS00735
uniprot id: A0A0U4N032
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

1653476:THC RS02140
gene id: 1653476:THC_RS02140
uniprot id: A0A0U5AW79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1653476:THC RS02240
gene id: 1653476:THC_RS02240
uniprot id: A0A0U5ALX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1653476:THC RS06680
gene id: 1653476:THC_RS06680
uniprot id: A0A0U5AIF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1653476:THC RS09040
gene id: 1653476:THC_RS09040
uniprot id: A0A0U5BZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1653476:THC RS07000
gene id: 1653476:THC_RS07000
uniprot id: A0A0U4W3V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1653476:THC RS01890
gene id: 1653476:THC_RS01890
uniprot id: A0A0U4W0V2
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1653476:THC RS03140
gene id: 1653476:THC_RS03140
uniprot id: A0A0U5ALY2
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1653476:THC RS00215
gene id: 1653476:THC_RS00215
uniprot id: A0A0U5AKL0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1653476:THC RS04070
gene id: 1653476:THC_RS04070
uniprot id: A0A0U4W296
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1653476:THC RS01725
gene id: 1653476:THC_RS01725
uniprot id: A0A0U5AW17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1653476:THC RS09050
gene id: 1653476:THC_RS09050
uniprot id: A0A0U5AJU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1653476:THC RS05505
gene id: 1653476:THC_RS05505
uniprot id: A0A0U4W316
names: Similarity
messages: Belongs to the UbiD family.

1653476:THC RS04750
gene id: 1653476:THC_RS04750
uniprot id: A0A0U5AZZ4
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1653476:THC RS07590
gene id: 1653476:THC_RS07590
uniprot id: A0A0U5B738
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1653476:THC RS05270
gene id: 1653476:THC_RS05270
uniprot id: A0A0U4W2X5
names: Similarity
messages: Belongs to the bacterial glucokinase family.

1653476:THC RS01530
gene id: 1653476:THC_RS01530
uniprot id: A0A0U5AFD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1653476:THC RS06760
gene id: 1653476:THC_RS06760
uniprot id: A0A0U4W3Q4
names: Similarity
messages: Belongs to the HupF/HypC family.

1653476:THC RS08055
gene id: 1653476:THC_RS08055
uniprot id: A0A0U4W4I4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03465
gene id: 1653476:THC_RS03465
uniprot id: A0A0U5BWR1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1653476:THC RS05190
gene id: 1653476:THC_RS05190
uniprot id: A0A0U5AXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

1653476:THC RS01720
gene id: 1653476:THC_RS01720
uniprot id: A0A0U4W0R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

1653476:THC RS01440
gene id: 1653476:THC_RS01440
uniprot id: A0A0U5BVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1653476:THC RS00005
gene id: 1653476:THC_RS00005
uniprot id: A0A0U5AXF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1653476:THC RS01640
gene id: 1653476:THC_RS01640
uniprot id: A0A0U5AW06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1653476:THC RS00480
gene id: 1653476:THC_RS00480
uniprot id: A0A0U5AES6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS05770
gene id: 1653476:THC_RS05770
uniprot id: A0A0U4W367
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1653476:THC RS05810
gene id: 1653476:THC_RS05810
uniprot id: A0A0U5AI13
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1653476:THC RS04135
gene id: 1653476:THC_RS04135
uniprot id: A0A0U5BX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1653476:THC RS07750
gene id: 1653476:THC_RS07750
uniprot id: A0A0U5B768
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS03450
gene id: 1653476:THC_RS03450
uniprot id: A0A0U5AMN2
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02900
gene id: 1653476:THC_RS02900
uniprot id: A0A0U5BWH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1653476:THC RS01970
gene id: 1653476:THC_RS01970
uniprot id: A0A0U4W0X1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1653476:THC RS04095
gene id: 1653476:THC_RS04095
uniprot id: A0A0U5B569
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1653476:THC RS07425
gene id: 1653476:THC_RS07425
uniprot id: A0A0U5AYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1653476:THC RS07970
gene id: 1653476:THC_RS07970
uniprot id: A0A0U4W4G7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04085
gene id: 1653476:THC_RS04085
uniprot id: A0A0U5AX67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1653476:THC RS06380
gene id: 1653476:THC_RS06380
uniprot id: A0A0U5ARV6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1653476:THC RS06410
gene id: 1653476:THC_RS06410
uniprot id: A0A0U5AID3
names: Similarity
messages: Belongs to the peptidase C56 family.

1653476:THC RS09025
gene id: 1653476:THC_RS09025
uniprot id: A0A0U5AQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS01275
gene id: 1653476:THC_RS01275
uniprot id: A0A0U4N0E0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1653476:THC RS08170
gene id: 1653476:THC_RS08170
uniprot id: A0A0U5AJA1
names: Similarity
messages: Belongs to the Ahb/Nir family.

1653476:THC RS00145
gene id: 1653476:THC_RS00145
uniprot id: A0A0U5AK18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS06705
gene id: 1653476:THC_RS06705
uniprot id: A0A0U5AS16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS02095
gene id: 1653476:THC_RS02095
uniprot id: A0A0U5AL73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1653476:THC RS08510
gene id: 1653476:THC_RS08510
uniprot id: A0A0U5AZW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1653476:THC RS01155
gene id: 1653476:THC_RS01155
uniprot id: A0A0U5AW68
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1653476:THC RS01260
gene id: 1653476:THC_RS01260
uniprot id: A0A0U5AF77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1653476:THC RS08315
gene id: 1653476:THC_RS08315
uniprot id: A0A0U4W4N5
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

1653476:THC RS05040
gene id: 1653476:THC_RS05040
uniprot id: A0A0U5AR66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1653476:THC RS04530
gene id: 1653476:THC_RS04530
uniprot id: A0A0U5B5E5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00065
gene id: 1653476:THC_RS00065
uniprot id: A0A0U5AK08
names: Similarity
messages: Belongs to the UPF0173 family.

1653476:THC RS01305
gene id: 1653476:THC_RS01305
uniprot id: A0A0U5AF82
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1653476:THC RS07655
gene id: 1653476:THC_RS07655
uniprot id: A0A0U4W485
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1653476:THC RS05775
gene id: 1653476:THC_RS05775
uniprot id: A0A0U5AHZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04330
gene id: 1653476:THC_RS04330
uniprot id: A0A0U5AZT0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1653476:THC RS01475
gene id: 1653476:THC_RS01475
uniprot id: A0A0U5AFB1
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

1653476:THC RS03960
gene id: 1653476:THC_RS03960
uniprot id: A0A0U5AGS9
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1653476:THC RS01815
gene id: 1653476:THC_RS01815
uniprot id: A0A0U5B406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS04215
gene id: 1653476:THC_RS04215
uniprot id: A0A0U5BX26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1653476:THC RS04890
gene id: 1653476:THC_RS04890
uniprot id: A0A0U5BXD2
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS06220
gene id: 1653476:THC_RS06220
uniprot id: A0A0U5AI91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1653476:THC RS04620
gene id: 1653476:THC_RS04620
uniprot id: A0A0U5AN69
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1653476:THC RS04270
gene id: 1653476:THC_RS04270
uniprot id: A0A0U5AXS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1653476:THC RS01565
gene id: 1653476:THC_RS01565
uniprot id: A0A0U5AVZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1653476:THC RS05335
gene id: 1653476:THC_RS05335
uniprot id: A0A0U5B0A0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1653476:THC RS03385
gene id: 1653476:THC_RS03385
uniprot id: A0A0U5AM25
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1653476:THC RS01360
gene id: 1653476:THC_RS01360
uniprot id: A0A0U4N0F8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1653476:THC RS07955
gene id: 1653476:THC_RS07955
uniprot id: A0A0U5AX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

1653476:THC RS00555
gene id: 1653476:THC_RS00555
uniprot id: A0A0U4N001
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1653476:THC RS04415
gene id: 1653476:THC_RS04415
uniprot id: A0A0U5AZU4
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1653476:THC RS00345
gene id: 1653476:THC_RS00345
uniprot id: A0A0U5AEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1653476:THC RS01650
gene id: 1653476:THC_RS01650
uniprot id: A0A0U5B3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1653476:THC RS04290
gene id: 1653476:THC_RS04290
uniprot id: A0A0U5AGZ0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1653476:THC RS00675
gene id: 1653476:THC_RS00675
uniprot id: A0A0U4W031
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1653476:THC RS05780
gene id: 1653476:THC_RS05780
uniprot id: A0A0U4W361
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS02225
gene id: 1653476:THC_RS02225
uniprot id: A0A0U5AWP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1653476:THC RS07885
gene id: 1653476:THC_RS07885
uniprot id: A0A0U4W4D4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1653476:THC RS08080
gene id: 1653476:THC_RS08080
uniprot id: A0A0U5B7D8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS03390
gene id: 1653476:THC_RS03390
uniprot id: A0A0U5BWQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1653476:THC RS05690
gene id: 1653476:THC_RS05690
uniprot id: A0A0U5AHY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1653476:THC RS05400
gene id: 1653476:THC_RS05400
uniprot id: A0A0U5BXL6
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1653476:THC RS09710
gene id: 1653476:THC_RS09710
uniprot id: A0A0U5APY9
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1653476:THC RS08505
gene id: 1653476:THC_RS08505
uniprot id: A0A0U5AZD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1653476:THC RS00195
gene id: 1653476:THC_RS00195
uniprot id: A0A0U5AV93
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1653476:THC RS05005
gene id: 1653476:THC_RS05005
uniprot id: A0A0U4W2T2
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1653476:THC RS00235
gene id: 1653476:THC_RS00235
uniprot id: A0A0U4MZU1
names: Similarity
messages: Belongs to the peptidase S41A family.

1653476:THC RS01500
gene id: 1653476:THC_RS01500
uniprot id: A0A0U5APD9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1653476:THC RS08295
gene id: 1653476:THC_RS08295
uniprot id: A0A0U4N405
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1653476:THC RS08110
gene id: 1653476:THC_RS08110
uniprot id: A0A0U5BYU9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1653476:THC RS00960
gene id: 1653476:THC_RS00960
uniprot id: A0A0U4N080
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

1653476:THC RS06105
gene id: 1653476:THC_RS06105
uniprot id: A0A0U5AYP5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1653476:THC RS08305
gene id: 1653476:THC_RS08305
uniprot id: A0A0U5AXA1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1653476:THC RS01385
gene id: 1653476:THC_RS01385
uniprot id: A0A0U4W0H6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1653476:THC RS02515
gene id: 1653476:THC_RS02515
uniprot id: A0A0U5AYU2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

1653476:THC RS07605
gene id: 1653476:THC_RS07605
uniprot id: A0A0U5AJ04
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1653476:THC RS00180
gene id: 1653476:THC_RS00180
uniprot id: A0A0U4VZT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1653476:THC RS06980
gene id: 1653476:THC_RS06980
uniprot id: A0A0U5AIQ9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1653476:THC RS07690
gene id: 1653476:THC_RS07690
uniprot id: A0A0U5AP78
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1653476:THC RS04560
gene id: 1653476:THC_RS04560
uniprot id: A0A0U4N239
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS05490
gene id: 1653476:THC_RS05490
uniprot id: A0A0U5AHW5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1653476:THC RS06225
gene id: 1653476:THC_RS06225
uniprot id: A0A0U5ANH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1653476:THC RS06780
gene id: 1653476:THC_RS06780
uniprot id: A0A0U5AZ11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.
messages: Periplasm

1653476:THC RS00765
gene id: 1653476:THC_RS00765
uniprot id: A0A0U5AEW8
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

1653476:THC RS00825
gene id: 1653476:THC_RS00825
uniprot id: A0A0U4W063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1653476:THC RS08235
gene id: 1653476:THC_RS08235
uniprot id: A0A0U5B1P4
names: Similarity
messages: Belongs to the peptidase S49 family.

1653476:THC RS03920
gene id: 1653476:THC_RS03920
uniprot id: A0A0U5AX38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1653476:THC RS08245
gene id: 1653476:THC_RS08245
uniprot id: A0A0U4W4M1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1653476:THC RS09095
gene id: 1653476:THC_RS09095
uniprot id: A0A0U5B7V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

1653476:THC RS07195
gene id: 1653476:THC_RS07195
uniprot id: A0A0U5B6V8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1653476:THC RS00300
gene id: 1653476:THC_RS00300
uniprot id: A0A0U5AEP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1653476:THC RS05415
gene id: 1653476:THC_RS05415
uniprot id: A0A0U5AVZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1653476:THC RS02315
gene id: 1653476:THC_RS02315
uniprot id: A0A0U5APU8
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS01710
gene id: 1653476:THC_RS01710
uniprot id: A0A0U4W0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

1653476:THC RS02690
gene id: 1653476:THC_RS02690
uniprot id: A0A0U4W1B1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1653476:THC RS04150
gene id: 1653476:THC_RS04150
uniprot id: A0A0U5AVD6
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

1653476:THC RS00335
gene id: 1653476:THC_RS00335
uniprot id: A0A0U4VZW7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1653476:THC RS05720
gene id: 1653476:THC_RS05720
uniprot id: A0A0U5ANR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1653476:THC RS08735
gene id: 1653476:THC_RS08735
uniprot id: A0A0U4W4X6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS02145
gene id: 1653476:THC_RS02145
uniprot id: A0A0U5AWN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

1653476:THC RS08955
gene id: 1653476:THC_RS08955
uniprot id: A0A0U5APU7
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS08195
gene id: 1653476:THC_RS08195
uniprot id: A0A0U5ASW8
names: Subunit
messages: Homodimer.

1653476:THC RS06930
gene id: 1653476:THC_RS06930
uniprot id: A0A0U4W3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Membrane

1653476:THC RS05785
gene id: 1653476:THC_RS05785
uniprot id: A0A0U5AXZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1653476:THC RS06495
gene id: 1653476:THC_RS06495
uniprot id: A0A0U5AWG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS08590
gene id: 1653476:THC_RS08590
uniprot id: A0A0U5AZX7
names: Similarity
messages: Belongs to the GSP E family.

1653476:THC RS04585
gene id: 1653476:THC_RS04585
uniprot id: A0A0U4W2K0
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS03595
gene id: 1653476:THC_RS03595
uniprot id: A0A0U5AXF5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02525
gene id: 1653476:THC_RS02525
uniprot id: A0A0U4W173
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1653476:THC RS08485
gene id: 1653476:THC_RS08485
uniprot id: A0A0U4W4T2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS02835
gene id: 1653476:THC_RS02835
uniprot id: A0A0U5AUP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1653476:THC RS02940
gene id: 1653476:THC_RS02940
uniprot id: A0A0U4W1G7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1653476:THC RS07940
gene id: 1653476:THC_RS07940
uniprot id: A0A0U5BYS5
names: Similarity
messages: Belongs to the aspartokinase family.

1653476:THC RS08290
gene id: 1653476:THC_RS08290
uniprot id: A0A0U5BYX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07645
gene id: 1653476:THC_RS07645
uniprot id: A0A0U4W489
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

1653476:THC RS01105
gene id: 1653476:THC_RS01105
uniprot id: A0A0U5AKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1653476:THC RS08480
gene id: 1653476:THC_RS08480
uniprot id: A0A0U4W4T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1653476:THC RS02915
gene id: 1653476:THC_RS02915
uniprot id: A0A0U5AUS5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS01730
gene id: 1653476:THC_RS01730
uniprot id: A0A0U5AWI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

1653476:THC RS01120
gene id: 1653476:THC_RS01120
uniprot id: A0A0U5AF46
names: Similarity
messages: Belongs to the UPF0758 family.

1653476:THC RS05340
gene id: 1653476:THC_RS05340
uniprot id: A0A0U4W2Y4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1653476:THC RS08250
gene id: 1653476:THC_RS08250
uniprot id: A0A0U5AJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1653476:THC RS04075
gene id: 1653476:THC_RS04075
uniprot id: A0A0U5AGW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1653476:THC RS03995
gene id: 1653476:THC_RS03995
uniprot id: A0A0U5AX55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

1653476:THC RS05450
gene id: 1653476:THC_RS05450
uniprot id: A0A0U5AYC2
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS06180
gene id: 1653476:THC_RS06180
uniprot id: A0A0U4W3E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS02960
gene id: 1653476:THC_RS02960
uniprot id: A0A0U5AQ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1653476:THC RS01130
gene id: 1653476:THC_RS01130
uniprot id: A0A0U5AY22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1653476:THC RS05220
gene id: 1653476:THC_RS05220
uniprot id: A0A0U5AMZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1653476:THC RS00175
gene id: 1653476:THC_RS00175
uniprot id: A0A0U4VZS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1653476:THC RS03320
gene id: 1653476:THC_RS03320
uniprot id: A0A0U5AUZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS04000
gene id: 1653476:THC_RS04000
uniprot id: A0A0U5AXN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1653476:THC RS04855
gene id: 1653476:THC_RS04855
uniprot id: A0A0U5AXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1653476:THC RS00225
gene id: 1653476:THC_RS00225
uniprot id: A0A0U5AK31
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04470
gene id: 1653476:THC_RS04470
uniprot id: A0A0U5AML7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1653476:THC RS08365
gene id: 1653476:THC_RS08365
uniprot id: A0A0U5APK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1653476:THC RS09715
gene id: 1653476:THC_RS09715
uniprot id: A0A0U5AJD6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1653476:THC RS06175
gene id: 1653476:THC_RS06175
uniprot id: A0A0U5AI67
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03900
gene id: 1653476:THC_RS03900
uniprot id: A0A0U4W252
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1653476:THC RS09115
gene id: 1653476:THC_RS09115
uniprot id: A0A0U5APW4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1653476:THC RS07270
gene id: 1653476:THC_RS07270
uniprot id: A0A0U5B6Y4
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07705
gene id: 1653476:THC_RS07705
uniprot id: A0A0U5AJ57
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1653476:THC RS08730
gene id: 1653476:THC_RS08730
uniprot id: A0A0U4W4W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1653476:THC RS07330
gene id: 1653476:THC_RS07330
uniprot id: A0A0U5AIU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1653476:THC RS04605
gene id: 1653476:THC_RS04605
uniprot id: A0A0U5AXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1653476:THC RS00725
gene id: 1653476:THC_RS00725
uniprot id: A0A0U5AKD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03120
gene id: 1653476:THC_RS03120
uniprot id: A0A0U5AQA2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1653476:THC RS07575
gene id: 1653476:THC_RS07575
uniprot id: A0A0U4W469
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07275
gene id: 1653476:THC_RS07275
uniprot id: A0A0U5ASA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04810
gene id: 1653476:THC_RS04810
uniprot id: A0A0U5BXC1
names: Similarity
messages: Belongs to the TlyA family.

1653476:THC RS00885
gene id: 1653476:THC_RS00885
uniprot id: A0A0U5AF05
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1653476:THC RS07200
gene id: 1653476:THC_RS07200
uniprot id: A0A0U5AS92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1653476:THC RS08975
gene id: 1653476:THC_RS08975
uniprot id: A0A0U5AXM4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS01510
gene id: 1653476:THC_RS01510
uniprot id: A0A0U5AFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

1653476:THC RS06695
gene id: 1653476:THC_RS06695
uniprot id: A0A0U5AYZ6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1653476:THC RS02520
gene id: 1653476:THC_RS02520
uniprot id: A0A0U4W179
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1653476:THC RS02895
gene id: 1653476:THC_RS02895
uniprot id: A0A0U5ALU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1653476:THC RS01265
gene id: 1653476:THC_RS01265
uniprot id: A0A0U5AKP5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1653476:THC RS01255
gene id: 1653476:THC_RS01255
uniprot id: A0A0U5AL81
names: Similarity
messages: Belongs to the UPF0102 family.

1653476:THC RS00900
gene id: 1653476:THC_RS00900
uniprot id: A0A0U4W086
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS00410
gene id: 1653476:THC_RS00410
uniprot id: A0A0U5AT94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1653476:THC RS07715
gene id: 1653476:THC_RS07715
uniprot id: A0A0U5B1G9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1653476:THC RS01870
gene id: 1653476:THC_RS01870
uniprot id: A0A0U4W0U1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1653476:THC RS04970
gene id: 1653476:THC_RS04970
uniprot id: A0A0U5AHL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS03065
gene id: 1653476:THC_RS03065
uniprot id: A0A0U5AGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1653476:THC RS01955
gene id: 1653476:THC_RS01955
uniprot id: A0A0U4W0V5
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1653476:THC RS00535
gene id: 1653476:THC_RS00535
uniprot id: A0A0U5AKS1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS01965
gene id: 1653476:THC_RS01965
uniprot id: A0A0U5AFK5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1653476:THC RS05115
gene id: 1653476:THC_RS05115
uniprot id: A0A0U5AR81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1653476:THC RS08760
gene id: 1653476:THC_RS08760
uniprot id: A0A0U5B003
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

1653476:THC RS07290
gene id: 1653476:THC_RS07290
uniprot id: A0A0U5AP09
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1653476:THC RS04240
gene id: 1653476:THC_RS04240
uniprot id: A0A0U5AZR4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1653476:THC RS07515
gene id: 1653476:THC_RS07515
uniprot id: A0A0U5ASF3
names: Similarity
messages: Belongs to the peptidase S66 family.

1653476:THC RS04895
gene id: 1653476:THC_RS04895
uniprot id: A0A0U4N280
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1653476:THC RS07095
gene id: 1653476:THC_RS07095
uniprot id: A0A0U5AIP3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1653476:THC RS04685
gene id: 1653476:THC_RS04685
uniprot id: A0A0U5AXF9
names: Similarity
messages: Belongs to the YicC/YloC family.

1653476:THC RS06415
gene id: 1653476:THC_RS06415
uniprot id: A0A0U5AWF5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1653476:THC RS07060
gene id: 1653476:THC_RS07060
uniprot id: A0A0U5BYC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1653476:THC RS07925
gene id: 1653476:THC_RS07925
uniprot id: A0A0U5APU4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1653476:THC RS01925
gene id: 1653476:THC_RS01925
uniprot id: A0A0U5AL19
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS03985
gene id: 1653476:THC_RS03985
uniprot id: A0A0U5AGU7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1653476:THC RS05555
gene id: 1653476:THC_RS05555
uniprot id: A0A0U5AN57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03915
gene id: 1653476:THC_RS03915
uniprot id: A0A0U4W266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1653476:THC RS04090
gene id: 1653476:THC_RS04090
uniprot id: A0A0U5AXP7
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00950
gene id: 1653476:THC_RS00950
uniprot id: A0A0U5AKH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

1653476:THC RS06235
gene id: 1653476:THC_RS06235
uniprot id: A0A0U4N2U8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1653476:THC RS04360
gene id: 1653476:THC_RS04360
uniprot id: A0A0U5AXT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS04030
gene id: 1653476:THC_RS04030
uniprot id: A0A0U5AME3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1653476:THC RS05665
gene id: 1653476:THC_RS05665
uniprot id: A0A0U5AW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1653476:THC RS07735
gene id: 1653476:THC_RS07735
uniprot id: A0A0U4W4A3
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02285
gene id: 1653476:THC_RS02285
uniprot id: A0A0U4W125
names: Similarity
messages: Belongs to the P(II) protein family.

1653476:THC RS02680
gene id: 1653476:THC_RS02680
uniprot id: A0A0U5AUL3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1653476:THC RS08020
gene id: 1653476:THC_RS08020
uniprot id: A0A0U5APE3
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

1653476:THC RS04640
gene id: 1653476:THC_RS04640
uniprot id: A0A0U5BX93
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

1653476:THC RS04800
gene id: 1653476:THC_RS04800
uniprot id: A0A0U5AHH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1653476:THC RS03945
gene id: 1653476:THC_RS03945
uniprot id: A0A0U5AGQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1653476:THC RS08880
gene id: 1653476:THC_RS08880
uniprot id: A0A0U5BZ86
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1653476:THC RS06420
gene id: 1653476:THC_RS06420
uniprot id: A0A0U5B0T0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1653476:THC RS02560
gene id: 1653476:THC_RS02560
uniprot id: A0A0U5APZ9
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1653476:THC RS07370
gene id: 1653476:THC_RS07370
uniprot id: A0A0U5AP27
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

1653476:THC RS04745
gene id: 1653476:THC_RS04745
uniprot id: A0A0U5AVN7
names: Similarity
messages: Belongs to the peptidase A31 family.

1653476:THC RS05580
gene id: 1653476:THC_RS05580
uniprot id: A0A0U5B0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1653476:THC RS06090
gene id: 1653476:THC_RS06090
uniprot id: A0A0U4W3C7
names: Similarity
messages: Belongs to the ribF family.

1653476:THC RS06770
gene id: 1653476:THC_RS06770
uniprot id: A0A0U4W3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

1653476:THC RS05135
gene id: 1653476:THC_RS05135
uniprot id: A0A0U5BXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS04315
gene id: 1653476:THC_RS04315
uniprot id: A0A0U5AVG4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1653476:THC RS07565
gene id: 1653476:THC_RS07565
uniprot id: A0A0U4W471
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1653476:THC RS07080
gene id: 1653476:THC_RS07080
uniprot id: A0A0U5B149
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1653476:THC RS04080
gene id: 1653476:THC_RS04080
uniprot id: A0A0U4W2A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1653476:THC RS05070
gene id: 1653476:THC_RS05070
uniprot id: A0A0U5AVU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1653476:THC RS07025
gene id: 1653476:THC_RS07025
uniprot id: A0A0U5AZ55
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1653476:THC RS04160
gene id: 1653476:THC_RS04160
uniprot id: A0A0U4W2C4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1653476:THC RS08900
gene id: 1653476:THC_RS08900
uniprot id: A0A0U5B214
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1653476:THC RS02490
gene id: 1653476:THC_RS02490
uniprot id: A0A0U5ALJ5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1653476:THC RS03155
gene id: 1653476:THC_RS03155
uniprot id: A0A0U5AGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1653476:THC RS03640
gene id: 1653476:THC_RS03640
uniprot id: A0A0U5AV53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1653476:THC RS05685
gene id: 1653476:THC_RS05685
uniprot id: A0A0U4W350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

1653476:THC RS08430
gene id: 1653476:THC_RS08430
uniprot id: A0A0U5AT37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1653476:THC RS04920
gene id: 1653476:THC_RS04920
uniprot id: A0A0U4W2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1653476:THC RS03425
gene id: 1653476:THC_RS03425
uniprot id: A0A0U5AGF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1653476:THC RS00835
gene id: 1653476:THC_RS00835
uniprot id: A0A0U5AEY8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1653476:THC RS06745
gene id: 1653476:THC_RS06745
uniprot id: A0A0U5AWJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1653476:THC RS00420
gene id: 1653476:THC_RS00420
uniprot id: A0A0U4VZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1653476:THC RS01320
gene id: 1653476:THC_RS01320
uniprot id: A0A0U5AW98
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1653476:THC RS00715
gene id: 1653476:THC_RS00715
uniprot id: A0A0U5AKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1653476:THC RS06140
gene id: 1653476:THC_RS06140
uniprot id: A0A0U4N2T7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS00470
gene id: 1653476:THC_RS00470
uniprot id: A0A0U5BV77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1653476:THC RS07920
gene id: 1653476:THC_RS07920
uniprot id: A0A0U5ASM8
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08175
gene id: 1653476:THC_RS08175
uniprot id: A0A0U4W4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS00635
gene id: 1653476:THC_RS00635
uniprot id: A0A0U5AKB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1653476:THC RS07445
gene id: 1653476:THC_RS07445
uniprot id: A0A0U5AIX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1653476:THC RS00600
gene id: 1653476:THC_RS00600
uniprot id: A0A0U4W027
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1653476:THC RS02420
gene id: 1653476:THC_RS02420
uniprot id: A0A0U4N0X9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02860
gene id: 1653476:THC_RS02860
uniprot id: A0A0U4W1E4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1653476:THC RS02230
gene id: 1653476:THC_RS02230
uniprot id: A0A0U5B474
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1653476:THC RS08885
gene id: 1653476:THC_RS08885
uniprot id: A0A0U4N4B9
names: Similarity
messages: Belongs to the histone deacetylase family.

1653476:THC RS02100
gene id: 1653476:THC_RS02100
uniprot id: A0A0U5BW14
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1653476:THC RS06310
gene id: 1653476:THC_RS06310
uniprot id: A0A0U5ANI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1653476:THC RS05430
gene id: 1653476:THC_RS05430
uniprot id: A0A0U4W303
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS07510
gene id: 1653476:THC_RS07510
uniprot id: A0A0U5B729
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07410
gene id: 1653476:THC_RS07410
uniprot id: A0A0U4W434
names: Similarity
messages: Belongs to the DprA/Smf family.

1653476:THC RS03765
gene id: 1653476:THC_RS03765
uniprot id: A0A0U5B511
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1653476:THC RS05875
gene id: 1653476:THC_RS05875
uniprot id: A0A0U5AYK1
names: Similarity
messages: Belongs to the CutA family.

1653476:THC RS05495
gene id: 1653476:THC_RS05495
uniprot id: A0A0U5AW09
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1653476:THC RS07865
gene id: 1653476:THC_RS07865
uniprot id: A0A0U4N3S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1653476:THC RS02120
gene id: 1653476:THC_RS02120
uniprot id: A0A0U4W0Y3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1653476:THC RS01450
gene id: 1653476:THC_RS01450
uniprot id: A0A0U5AFB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1653476:THC RS00995
gene id: 1653476:THC_RS00995
uniprot id: A0A0U4W0B3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1653476:THC RS03055
gene id: 1653476:THC_RS03055
uniprot id: A0A0U5BWJ6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1653476:THC RS06690
gene id: 1653476:THC_RS06690
uniprot id: A0A0U5AYF4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1653476:THC RS08890
gene id: 1653476:THC_RS08890
uniprot id: A0A0U5AJR2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1653476:THC RS05205
gene id: 1653476:THC_RS05205
uniprot id: A0A0U5AR95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1653476:THC RS03555
gene id: 1653476:THC_RS03555
uniprot id: A0A0U5AV36
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1653476:THC RS03310
gene id: 1653476:THC_RS03310
uniprot id: A0A0U4N1G2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1653476:THC RS07820
gene id: 1653476:THC_RS07820
uniprot id: A0A0U4W4B6
names: Similarity
messages: Belongs to the RecJ family.

1653476:THC RS05550
gene id: 1653476:THC_RS05550
uniprot id: A0A0U5AHX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1653476:THC RS07910
gene id: 1653476:THC_RS07910
uniprot id: A0A0U5AZM6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1653476:THC RS02320
gene id: 1653476:THC_RS02320
uniprot id: A0A0U5ALZ8
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS03220
gene id: 1653476:THC_RS03220
uniprot id: A0A0U5BWM4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04130
gene id: 1653476:THC_RS04130
uniprot id: A0A0U5AMF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1653476:THC RS05085
gene id: 1653476:THC_RS05085
uniprot id: A0A0U4W2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1653476:THC RS08685
gene id: 1653476:THC_RS08685
uniprot id: A0A0U5AT93
names: Similarity
messages: Belongs to the fabD family.

1653476:THC RS08470
gene id: 1653476:THC_RS08470
uniprot id: A0A0U5AXD2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1653476:THC RS01740
gene id: 1653476:THC_RS01740
uniprot id: A0A0U5APJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1653476:THC RS04610
gene id: 1653476:THC_RS04610
uniprot id: A0A0U5B5F7
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08345
gene id: 1653476:THC_RS08345
uniprot id: A0A0U5B7H6
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS01705
gene id: 1653476:THC_RS01705
uniprot id: A0A0U4W0P7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

1653476:THC RS03115
gene id: 1653476:THC_RS03115
uniprot id: A0A0U5B4P9
names: Similarity
messages: Belongs to the threonine synthase family.

1653476:THC RS05970
gene id: 1653476:THC_RS05970
uniprot id: A0A0U5ANV8
names: Similarity
messages: Belongs to the asparagine synthetase family.

1653476:THC RS04425
gene id: 1653476:THC_RS04425
uniprot id: A0A0U4W2H1
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1653476:THC RS07550
gene id: 1653476:THC_RS07550
uniprot id: A0A0U5AWV8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1653476:THC RS05120
gene id: 1653476:THC_RS05120
uniprot id: A0A0U5ANG1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1653476:THC RS00440
gene id: 1653476:THC_RS00440
uniprot id: A0A0U5AVD9
names: Subunit
messages: Heterodimer of a large and a small subunit.

1653476:THC RS05295
gene id: 1653476:THC_RS05295
uniprot id: A0A0U5ANI9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS05640
gene id: 1653476:THC_RS05640
uniprot id: A0A0U5AHY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1653476:THC RS07100
gene id: 1653476:THC_RS07100
uniprot id: A0A0U4W3X6
names: Similarity
messages: Belongs to the peptidase S11 family.

1653476:THC RS03255
gene id: 1653476:THC_RS03255
uniprot id: A0A0U5AGD1
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS01455
gene id: 1653476:THC_RS01455
uniprot id: A0A0U5ATV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1653476:THC RS04200
gene id: 1653476:THC_RS04200
uniprot id: A0A0U5AN04
names: Similarity
messages: Belongs to the GSP E family.

1653476:THC RS08355
gene id: 1653476:THC_RS08355
uniprot id: A0A0U5APZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1653476:THC RS05730
gene id: 1653476:THC_RS05730
uniprot id: A0A0U5AN90
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS00290
gene id: 1653476:THC_RS00290
uniprot id: A0A0U5ANQ2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1653476:THC RS06940
gene id: 1653476:THC_RS06940
uniprot id: A0A0U5AZ42
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1653476:THC RS05560
gene id: 1653476:THC_RS05560
uniprot id: A0A0U5BXP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06120
gene id: 1653476:THC_RS06120
uniprot id: A0A0U5ANY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1653476:THC RS01535
gene id: 1653476:THC_RS01535
uniprot id: A0A0U5ATY0
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1653476:THC RS05635
gene id: 1653476:THC_RS05635
uniprot id: A0A0U5ANQ1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1653476:THC RS00670
gene id: 1653476:THC_RS00670
uniprot id: A0A0U5AXS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1653476:THC RS04700
gene id: 1653476:THC_RS04700
uniprot id: A0A0U5AR04
names: Similarity
messages: Belongs to the ycf81 family.

1653476:THC RS07320
gene id: 1653476:THC_RS07320
uniprot id: A0A0U4W404
names: Similarity
messages: Belongs to the leucine-binding protein family.

1653476:THC RS07730
gene id: 1653476:THC_RS07730
uniprot id: A0A0U5AJ17
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02345
gene id: 1653476:THC_RS02345
uniprot id: A0A0U5AFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1653476:THC RS01895
gene id: 1653476:THC_RS01895
uniprot id: A0A0U5AW41
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS01000
gene id: 1653476:THC_RS01000
uniprot id: A0A0U5AVN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1653476:THC RS03075
gene id: 1653476:THC_RS03075
uniprot id: A0A0U5AZ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1653476:THC RS08410
gene id: 1653476:THC_RS08410
uniprot id: A0A0U4W4R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1653476:THC RS08865
gene id: 1653476:THC_RS08865
uniprot id: A0A0U5AQ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1653476:THC RS04205
gene id: 1653476:THC_RS04205
uniprot id: A0A0U5AGV5
names: Similarity
messages: Belongs to the GSP E family.

1653476:THC RS05420
gene id: 1653476:THC_RS05420
uniprot id: A0A0U5B0A9
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1653476:THC RS05510
gene id: 1653476:THC_RS05510
uniprot id: A0A0U4W317
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1653476:THC RS01580
gene id: 1653476:THC_RS01580
uniprot id: A0A0U5APF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

1653476:THC RS03445
gene id: 1653476:THC_RS03445
uniprot id: A0A0U5AQF9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS06375
gene id: 1653476:THC_RS06375
uniprot id: A0A0U5B6D7
names: Similarity
messages: Belongs to the thioredoxin family.

1653476:THC RS00205
gene id: 1653476:THC_RS00205
uniprot id: A0A0U5B384
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1653476:THC RS07545
gene id: 1653476:THC_RS07545
uniprot id: A0A0U5AJ22
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1653476:THC RS06750
gene id: 1653476:THC_RS06750
uniprot id: A0A0U5B0Y9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1653476:THC RS00855
gene id: 1653476:THC_RS00855
uniprot id: A0A0U5B3G2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1653476:THC RS09010
gene id: 1653476:THC_RS09010
uniprot id: A0A0U5B061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the AccA family.
messages: In the N-terminal section; belongs to the AccD/PCCB family.

1653476:THC RS04880
gene id: 1653476:THC_RS04880
uniprot id: A0A0U5AHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1653476:THC RS05280
gene id: 1653476:THC_RS05280
uniprot id: A0A0U5AY93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane

1653476:THC RS02675
gene id: 1653476:THC_RS02675
uniprot id: A0A0U5AG10
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1653476:THC RS06965
gene id: 1653476:THC_RS06965
uniprot id: A0A0U5ANU6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1653476:THC RS03895
gene id: 1653476:THC_RS03895
uniprot id: A0A0U5AZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1653476:THC RS09620
gene id: 1653476:THC_RS09620
uniprot id: A0A0U4W3J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS01280
gene id: 1653476:THC_RS01280
uniprot id: A0A0U5AF81
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1653476:THC RS08415
gene id: 1653476:THC_RS08415
uniprot id: A0A0U5AZC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1653476:THC RS04025
gene id: 1653476:THC_RS04025
uniprot id: A0A0U5AGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1653476:THC RS04355
gene id: 1653476:THC_RS04355
uniprot id: A0A0U5AXA5
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS02200
gene id: 1653476:THC_RS02200
uniprot id: A0A0U4W103
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1653476:THC RS06800
gene id: 1653476:THC_RS06800
uniprot id: A0A0U5AIJ4
names: Similarity
messages: Belongs to the P(II) protein family.

1653476:THC RS08850
gene id: 1653476:THC_RS08850
uniprot id: A0A0U5B7Q9
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1653476:THC RS00505
gene id: 1653476:THC_RS00505
uniprot id: A0A0U5AES3
names: Similarity
messages: Belongs to the glutamate synthase family.

1653476:THC RS02485
gene id: 1653476:THC_RS02485
uniprot id: A0A0U5AFW1
names: Similarity
messages: Belongs to the CinA family.

1653476:THC RS06995
gene id: 1653476:THC_RS06995
uniprot id: A0A0U4W3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1653476:THC RS07935
gene id: 1653476:THC_RS07935
uniprot id: A0A0U5APD0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1653476:THC RS01290
gene id: 1653476:THC_RS01290
uniprot id: A0A0U5AY57
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1653476:THC RS01505
gene id: 1653476:THC_RS01505
uniprot id: A0A0U5ALH1
names: Similarity
messages: Belongs to the MotB family.

1653476:THC RS00350
gene id: 1653476:THC_RS00350
uniprot id: A0A0U4VZY4
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1653476:THC RS03910
gene id: 1653476:THC_RS03910
uniprot id: A0A0U5AGQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1653476:THC RS01180
gene id: 1653476:THC_RS01180
uniprot id: A0A0U5AKM9
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1653476:THC RS00115
gene id: 1653476:THC_RS00115
uniprot id: A0A0U5AV78
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03830
gene id: 1653476:THC_RS03830
uniprot id: A0A0U5AGP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

1653476:THC RS02110
gene id: 1653476:THC_RS02110
uniprot id: A0A0U5AFP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1653476:THC RS00280
gene id: 1653476:THC_RS00280
uniprot id: A0A0U5AVR5
names: Similarity
messages: Belongs to the UPF0235 family.

1653476:THC RS06635
gene id: 1653476:THC_RS06635
uniprot id: A0A0U5ANP3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1653476:THC RS02380
gene id: 1653476:THC_RS02380
uniprot id: A0A0U4W148
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

1653476:THC RS08400
gene id: 1653476:THC_RS08400
uniprot id: A0A0U4W4R6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1653476:THC RS08370
gene id: 1653476:THC_RS08370
uniprot id: A0A0U4W015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1653476:THC RS02800
gene id: 1653476:THC_RS02800
uniprot id: A0A0U5B4H7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1653476:THC RS08440
gene id: 1653476:THC_RS08440
uniprot id: A0A0U5AJH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1653476:THC RS04465
gene id: 1653476:THC_RS04465
uniprot id: A0A0U5AH39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1653476:THC RS03040
gene id: 1653476:THC_RS03040
uniprot id: A0A0U5AQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1653476:THC RS01605
gene id: 1653476:THC_RS01605
uniprot id: A0A0U5AFF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1653476:THC RS00390
gene id: 1653476:THC_RS00390
uniprot id: A0A0U5BV65
names: Similarity
messages: Belongs to the CobH/CbiC family.

1653476:THC RS01990
gene id: 1653476:THC_RS01990
uniprot id: A0A0U5B434
names: Similarity
messages: Belongs to the creatininase superfamily.

1653476:THC RS00270
gene id: 1653476:THC_RS00270
uniprot id: A0A0U4VZW8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS02460
gene id: 1653476:THC_RS02460
uniprot id: A0A0U5AWE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1653476:THC RS02455
gene id: 1653476:THC_RS02455
uniprot id: A0A0U4W166
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1653476:THC RS08455
gene id: 1653476:THC_RS08455
uniprot id: A0A0U5BZ13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1653476:THC RS06110
gene id: 1653476:THC_RS06110
uniprot id: A0A0U5B685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS00550
gene id: 1653476:THC_RS00550
uniprot id: A0A0U5BV93
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1653476:THC RS00580
gene id: 1653476:THC_RS00580
uniprot id: A0A0U4W015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1653476:THC RS00955
gene id: 1653476:THC_RS00955
uniprot id: A0A0U5BVG6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

1653476:THC RS04540
gene id: 1653476:THC_RS04540
uniprot id: A0A0U5AN56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS02105
gene id: 1653476:THC_RS02105
uniprot id: A0A0U4N0S2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1653476:THC RS04490
gene id: 1653476:THC_RS04490
uniprot id: A0A0U5AVJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS09020
gene id: 1653476:THC_RS09020
uniprot id: A0A0U5ATE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1653476:THC RS00090
gene id: 1653476:THC_RS00090
uniprot id: A0A0U5AXG7
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1653476:THC RS08770
gene id: 1653476:THC_RS08770
uniprot id: A0A0U5ATA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1653476:THC RS04715
gene id: 1653476:THC_RS04715
uniprot id: A0A0U5AHD7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1653476:THC RS03395
gene id: 1653476:THC_RS03395
uniprot id: A0A0U4N1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1653476:THC RS08670
gene id: 1653476:THC_RS08670
uniprot id: A0A0U5AZG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1653476:THC RS09065
gene id: 1653476:THC_RS09065
uniprot id: A0A0U4W535
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS08765
gene id: 1653476:THC_RS08765
uniprot id: A0A0U5B7P3
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1653476:THC RS00760
gene id: 1653476:THC_RS00760
uniprot id: A0A0U4W064
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

1653476:THC RS00605
gene id: 1653476:THC_RS00605
uniprot id: A0A0U5AVG8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1653476:THC RS05795
gene id: 1653476:THC_RS05795
uniprot id: A0A0U5B627
names: Similarity
messages: Belongs to the Ahb/Nir family.

1653476:THC RS00755
gene id: 1653476:THC_RS00755
uniprot id: A0A0U4W049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1653476:THC RS08450
gene id: 1653476:THC_RS08450
uniprot id: A0A0U5APL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1653476:THC RS04790
gene id: 1653476:THC_RS04790
uniprot id: A0A0U5AR21
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1653476:THC RS05820
gene id: 1653476:THC_RS05820
uniprot id: A0A0U5BXT9
names: Similarity
messages: Belongs to the class-I fumarase family.

1653476:THC RS09625
gene id: 1653476:THC_RS09625
uniprot id: A0A0U5AYB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1653476:THC RS07850
gene id: 1653476:THC_RS07850
uniprot id: A0A0U5AJ56
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1653476:THC RS01960
gene id: 1653476:THC_RS01960
uniprot id: A0A0U4W0V6
names: Similarity
messages: Belongs to the peptidase S24 family.

1653476:THC RS06100
gene id: 1653476:THC_RS06100
uniprot id: A0A0U4W3D6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1653476:THC RS07310
gene id: 1653476:THC_RS07310
uniprot id: A0A0U5AWR5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00265
gene id: 1653476:THC_RS00265
uniprot id: A0A0U5AEM2
names: Similarity
messages: Belongs to the GSP E family.

1653476:THC RS07315
gene id: 1653476:THC_RS07315
uniprot id: A0A0U5B191
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07265
gene id: 1653476:THC_RS07265
uniprot id: A0A0U5AZ96
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1653476:THC RS04420
gene id: 1653476:THC_RS04420
uniprot id: A0A0U4W2H2
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1653476:THC RS03165
gene id: 1653476:THC_RS03165
uniprot id: A0A0U5AZ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1653476:THC RS07725
gene id: 1653476:THC_RS07725
uniprot id: A0A0U4W4A5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08160
gene id: 1653476:THC_RS08160
uniprot id: A0A0U4W4I8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1653476:THC RS07055
gene id: 1653476:THC_RS07055
uniprot id: A0A0U5ANW1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1653476:THC RS01375
gene id: 1653476:THC_RS01375
uniprot id: A0A0U5ATU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS03260
gene id: 1653476:THC_RS03260
uniprot id: A0A0U4W1P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

1653476:THC RS04925
gene id: 1653476:THC_RS04925
uniprot id: A0A0U4W2Q9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1653476:THC RS05275
gene id: 1653476:THC_RS05275
uniprot id: A0A0U5AXR2
names: Similarity
messages: Belongs to the Skp family.

1653476:THC RS07335
gene id: 1653476:THC_RS07335
uniprot id: A0A0U4W424
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1653476:THC RS00080
gene id: 1653476:THC_RS00080
uniprot id: A0A0U5AEJ2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1653476:THC RS08395
gene id: 1653476:THC_RS08395
uniprot id: A0A0U4W4R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1653476:THC RS04690
gene id: 1653476:THC_RS04690
uniprot id: A0A0U5AXZ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS06700
gene id: 1653476:THC_RS06700
uniprot id: A0A0U5B6K1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04600
gene id: 1653476:THC_RS04600
uniprot id: A0A0U5AXE8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1653476:THC RS06805
gene id: 1653476:THC_RS06805
uniprot id: A0A0U5ANS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS00015
gene id: 1653476:THC_RS00015
uniprot id: A0A0U4VZQ9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1653476:THC RS00305
gene id: 1653476:THC_RS00305
uniprot id: A0A0U5AK47
names: Similarity
messages: Belongs to the GARS family.

1653476:THC RS09055
gene id: 1653476:THC_RS09055
uniprot id: A0A0U5AXN6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1653476:THC RS06050
gene id: 1653476:THC_RS06050
uniprot id: A0A0U5AI58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1653476:THC RS06045
gene id: 1653476:THC_RS06045
uniprot id: A0A0U5ANX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1653476:THC RS07805
gene id: 1653476:THC_RS07805
uniprot id: A0A0U4W4A0
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04630
gene id: 1653476:THC_RS04630
uniprot id: A0A0U5AH96
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1653476:THC RS06505
gene id: 1653476:THC_RS06505
uniprot id: A0A0U4W3J9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS05075
gene id: 1653476:THC_RS05075
uniprot id: A0A0U5B053
names: Similarity
messages: Belongs to the GPI family.

1653476:THC RS06265
gene id: 1653476:THC_RS06265
uniprot id: A0A0U4W3G7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1653476:THC RS07190
gene id: 1653476:THC_RS07190
uniprot id: A0A0U5AZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1653476:THC RS06910
gene id: 1653476:THC_RS06910
uniprot id: A0A0U5B113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1653476:THC RS04760
gene id: 1653476:THC_RS04760
uniprot id: A0A0U4W2N0
names: Similarity
messages: Belongs to the HypE family.

1653476:THC RS00020
gene id: 1653476:THC_RS00020
uniprot id: A0A0U5AEG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06465
gene id: 1653476:THC_RS06465
uniprot id: A0A0U5AP43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS00720
gene id: 1653476:THC_RS00720
uniprot id: A0A0U5AEW9
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1653476:THC RS09100
gene id: 1653476:THC_RS09100
uniprot id: A0A0U5ATF8
names: Similarity
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.

1653476:THC RS07535
gene id: 1653476:THC_RS07535
uniprot id: A0A0U5BYK6
names: Similarity
messages: Belongs to the transglycosylase Slt family.

1653476:THC RS07695
gene id: 1653476:THC_RS07695
uniprot id: A0A0U5BYN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1653476:THC RS06820
gene id: 1653476:THC_RS06820
uniprot id: A0A0U5AIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1653476:THC RS03760
gene id: 1653476:THC_RS03760
uniprot id: A0A0U5AXI2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1653476:THC RS03415
gene id: 1653476:THC_RS03415
uniprot id: A0A0U4W1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1653476:THC RS07875
gene id: 1653476:THC_RS07875
uniprot id: A0A0U5AX32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1653476:THC RS06360
gene id: 1653476:THC_RS06360
uniprot id: A0A0U5AYA0
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

1653476:THC RS08585
gene id: 1653476:THC_RS08585
uniprot id: A0A0U5AZF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1653476:THC RS03195
gene id: 1653476:THC_RS03195
uniprot id: A0A0U5B4R3
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07840
gene id: 1653476:THC_RS07840
uniprot id: A0A0U5ASL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

1653476:THC RS07110
gene id: 1653476:THC_RS07110
uniprot id: A0A0U5AYM7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

1653476:THC RS01390
gene id: 1653476:THC_RS01390
uniprot id: A0A0U4W0J2
names: Similarity
messages: Belongs to the peptidase U62 family.

1653476:THC RS05305
gene id: 1653476:THC_RS05305
uniprot id: A0A0U5AN13
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1653476:THC RS06955
gene id: 1653476:THC_RS06955
uniprot id: A0A0U5APC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.
messages: Homodimer.

1653476:THC RS06950
gene id: 1653476:THC_RS06950
uniprot id: A0A0U5AS52
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1653476:THC RS00750
gene id: 1653476:THC_RS00750
uniprot id: A0A0U5AXT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

1653476:THC RS07075
gene id: 1653476:THC_RS07075
uniprot id: A0A0U5AWN9
names: Similarity
messages: Belongs to the peptidase M18 family.

1653476:THC RS06115
gene id: 1653476:THC_RS06115
uniprot id: A0A0U5ARR1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06315
gene id: 1653476:THC_RS06315
uniprot id: A0A0U5BY03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1653476:THC RS07005
gene id: 1653476:THC_RS07005
uniprot id: A0A0U5AIM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1653476:THC RS05240
gene id: 1653476:THC_RS05240
uniprot id: A0A0U5AVW7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1653476:THC RS00200
gene id: 1653476:THC_RS00200
uniprot id: A0A0U5AVQ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS00595
gene id: 1653476:THC_RS00595
uniprot id: A0A0U5AET8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1653476:THC RS01310
gene id: 1653476:THC_RS01310
uniprot id: A0A0U4W0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1653476:THC RS08115
gene id: 1653476:THC_RS08115
uniprot id: A0A0U4N3X5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1653476:THC RS05410
gene id: 1653476:THC_RS05410
uniprot id: A0A0U5AHU6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1653476:THC RS04545
gene id: 1653476:THC_RS04545
uniprot id: A0A0U5AH69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1653476:THC RS03360
gene id: 1653476:THC_RS03360
uniprot id: A0A0U5AXB5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00415
gene id: 1653476:THC_RS00415
uniprot id: A0A0U5AXM7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1653476:THC RS04550
gene id: 1653476:THC_RS04550
uniprot id: A0A0U5AMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS04795
gene id: 1653476:THC_RS04795
uniprot id: A0A0U5ANA8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1653476:THC RS00310
gene id: 1653476:THC_RS00310
uniprot id: A0A0U5BV48
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1653476:THC RS04385
gene id: 1653476:THC_RS04385
uniprot id: A0A0U5AMK1
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS00500
gene id: 1653476:THC_RS00500
uniprot id: A0A0U4W016
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1653476:THC RS05880
gene id: 1653476:THC_RS05880
uniprot id: A0A0U5B641
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1653476:THC RS00685
gene id: 1653476:THC_RS00685
uniprot id: A0A0U5AEV5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1653476:THC RS04510
gene id: 1653476:THC_RS04510
uniprot id: A0A0U5AH91
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS01350
gene id: 1653476:THC_RS01350
uniprot id: A0A0U5AKS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1653476:THC RS09675
gene id: 1653476:THC_RS09675
uniprot id: A0A0U4N1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1653476:THC RS06510
gene id: 1653476:THC_RS06510
uniprot id: A0A0U4W3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1653476:THC RS06400
gene id: 1653476:THC_RS06400
uniprot id: A0A0U5BY13
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1653476:THC RS01735
gene id: 1653476:THC_RS01735
uniprot id: A0A0U5B3Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

1653476:THC RS06480
gene id: 1653476:THC_RS06480
uniprot id: A0A0U5BY28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS02885
gene id: 1653476:THC_RS02885
uniprot id: A0A0U5AME1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1653476:THC RS00625
gene id: 1653476:THC_RS00625
uniprot id: A0A0U5AKT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1653476:THC RS02555
gene id: 1653476:THC_RS02555
uniprot id: A0A0U5B4D8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1653476:THC RS03370
gene id: 1653476:THC_RS03370
uniprot id: A0A0U5AQE2
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07660
gene id: 1653476:THC_RS07660
uniprot id: A0A0U5AYY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1653476:THC RS03410
gene id: 1653476:THC_RS03410
uniprot id: A0A0U5AZB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1653476:THC RS00620
gene id: 1653476:THC_RS00620
uniprot id: A0A0U5ANV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1653476:THC RS03030
gene id: 1653476:THC_RS03030
uniprot id: A0A0U5AX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1653476:THC RS00315
gene id: 1653476:THC_RS00315
uniprot id: A0A0U4MZV5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS00375
gene id: 1653476:THC_RS00375
uniprot id: A0A0U5AKP1
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1653476:THC RS04485
gene id: 1653476:THC_RS04485
uniprot id: A0A0U5AH65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1653476:THC RS00165
gene id: 1653476:THC_RS00165
uniprot id: A0A0U5AT21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1653476:THC RS08150
gene id: 1653476:THC_RS08150
uniprot id: A0A0U5AX70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1653476:THC RS03870
gene id: 1653476:THC_RS03870
uniprot id: A0A0U5AMB6
names: Similarity
messages: Belongs to the MEMO1 family.

1653476:THC RS02645
gene id: 1653476:THC_RS02645
uniprot id: A0A0U5AFY9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1653476:THC RS01185
gene id: 1653476:THC_RS01185
uniprot id: A0A0U5BVK5
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1653476:THC RS03905
gene id: 1653476:THC_RS03905
uniprot id: A0A0U4W264
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07825
gene id: 1653476:THC_RS07825
uniprot id: A0A0U5AZ17
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1653476:THC RS08465
gene id: 1653476:THC_RS08465
uniprot id: A0A0U5AJI7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1653476:THC RS01700
gene id: 1653476:THC_RS01700
uniprot id: A0A0U5AYD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

1653476:THC RS02190
gene id: 1653476:THC_RS02190
uniprot id: A0A0U5AUB3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1653476:THC RS00795
gene id: 1653476:THC_RS00795
uniprot id: A0A0U5AKV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1653476:THC RS01445
gene id: 1653476:THC_RS01445
uniprot id: A0A0U4N0H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1653476:THC RS01805
gene id: 1653476:THC_RS01805
uniprot id: A0A0U5AW28
names: Similarity
messages: Belongs to the universal stress protein A family.

1653476:THC RS01070
gene id: 1653476:THC_RS01070
uniprot id: A0A0U5AF32
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1653476:THC RS02400
gene id: 1653476:THC_RS02400
uniprot id: A0A0U5AM12
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1653476:THC RS05800
gene id: 1653476:THC_RS05800
uniprot id: A0A0U5ARK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

1653476:THC RS07870
gene id: 1653476:THC_RS07870
uniprot id: A0A0U5AJ91
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1653476:THC RS08635
gene id: 1653476:THC_RS08635
uniprot id: A0A0U5AXG1
names: Similarity
messages: Belongs to the PilY1 family.

1653476:THC RS05210
gene id: 1653476:THC_RS05210
uniprot id: A0A0U5ANH7
names: Similarity
messages: Belongs to the PstS family.

1653476:THC RS02260
gene id: 1653476:THC_RS02260
uniprot id: A0A0U4N0V3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1653476:THC RS00880
gene id: 1653476:THC_RS00880
uniprot id: A0A0U4N061
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1653476:THC RS03650
gene id: 1653476:THC_RS03650
uniprot id: A0A0U4W223
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS01840
gene id: 1653476:THC_RS01840
uniprot id: A0A0U5BVX4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1653476:THC RS03560
gene id: 1653476:THC_RS03560
uniprot id: A0A0U5AZE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1653476:THC RS01460
gene id: 1653476:THC_RS01460
uniprot id: A0A0U5AY91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1653476:THC RS00340
gene id: 1653476:THC_RS00340
uniprot id: A0A0U4VZW9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1653476:THC RS07595
gene id: 1653476:THC_RS07595
uniprot id: A0A0U5ASG7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1653476:THC RS08920
gene id: 1653476:THC_RS08920
uniprot id: A0A0U4W4Z8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1653476:THC RS03605
gene id: 1653476:THC_RS03605
uniprot id: A0A0U5AQI7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1653476:THC RS04945
gene id: 1653476:THC_RS04945
uniprot id: A0A0U5AXK9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1653476:THC RS02005
gene id: 1653476:THC_RS02005
uniprot id: A0A0U5AFL7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1653476:THC RS02290
gene id: 1653476:THC_RS02290
uniprot id: A0A0U5AFT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS00540
gene id: 1653476:THC_RS00540
uniprot id: A0A0U5AEU6
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS02580
gene id: 1653476:THC_RS02580
uniprot id: A0A0U5BWA0
names: Similarity
messages: Belongs to the RuvC family.

1653476:THC RS06655
gene id: 1653476:THC_RS06655
uniprot id: A0A0U5AWI5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1653476:THC RS08675
gene id: 1653476:THC_RS08675
uniprot id: A0A0U5AZZ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06435
gene id: 1653476:THC_RS06435
uniprot id: A0A0U5AIB0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1653476:THC RS02070
gene id: 1653476:THC_RS02070
uniprot id: A0A0U5B449
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1653476:THC RS05565
gene id: 1653476:THC_RS05565
uniprot id: A0A0U4N2J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1653476:THC RS02505
gene id: 1653476:THC_RS02505
uniprot id: A0A0U5AFX4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1653476:THC RS00710
gene id: 1653476:THC_RS00710
uniprot id: A0A0U5ANX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1653476:THC RS02575
gene id: 1653476:THC_RS02575
uniprot id: A0A0U5ALL1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1653476:THC RS00155
gene id: 1653476:THC_RS00155
uniprot id: A0A0U4MZS7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1653476:THC RS07980
gene id: 1653476:THC_RS07980
uniprot id: A0A0U4W4E3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1653476:THC RS05235
gene id: 1653476:THC_RS05235
uniprot id: A0A0U5AHQ9
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08715
gene id: 1653476:THC_RS08715
uniprot id: A0A0U5AJN6
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

1653476:THC RS03975
gene id: 1653476:THC_RS03975
uniprot id: A0A0U4W280
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1653476:THC RS06785
gene id: 1653476:THC_RS06785
uniprot id: A0A0U5B6L4
names: Function
names: Subunit
messages: Interacts with sigma-54.
messages: Required for activation of most nif operons, which are directly involved in nitrogen fixation.

1653476:THC RS04870
gene id: 1653476:THC_RS04870
uniprot id: A0A0U5AR40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS06515
gene id: 1653476:THC_RS06515
uniprot id: A0A0U5AIC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS03925
gene id: 1653476:THC_RS03925
uniprot id: A0A0U5AXL8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS07430
gene id: 1653476:THC_RS07430
uniprot id: A0A0U5AZC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1653476:THC RS08405
gene id: 1653476:THC_RS08405
uniprot id: A0A0U5AJF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1653476:THC RS06500
gene id: 1653476:THC_RS06500
uniprot id: A0A0U5B0U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS09030
gene id: 1653476:THC_RS09030
uniprot id: A0A0U5AJT8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS04125
gene id: 1653476:THC_RS04125
uniprot id: A0A0U5AGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1653476:THC RS08520
gene id: 1653476:THC_RS08520
uniprot id: A0A0U5AT66
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1653476:THC RS08075
gene id: 1653476:THC_RS08075
uniprot id: A0A0U5AZQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1653476:THC RS00905
gene id: 1653476:THC_RS00905
uniprot id: A0A0U4W092
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

1653476:THC RS03970
gene id: 1653476:THC_RS03970
uniprot id: A0A0U5AZM5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1653476:THC RS01685
gene id: 1653476:THC_RS01685
uniprot id: A0A0U5AFG5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS02790
gene id: 1653476:THC_RS02790
uniprot id: A0A0U5AWL0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1653476:THC RS08540
gene id: 1653476:THC_RS08540
uniprot id: A0A0U5APM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1653476:THC RS01405
gene id: 1653476:THC_RS01405
uniprot id: A0A0U5AVW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1653476:THC RS05050
gene id: 1653476:THC_RS05050
uniprot id: A0A0U5AHM8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1653476:THC RS06490
gene id: 1653476:THC_RS06490
uniprot id: A0A0U5AIF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1653476:THC RS00610
gene id: 1653476:THC_RS00610
uniprot id: A0A0U5AVW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1653476:THC RS00630
gene id: 1653476:THC_RS00630
uniprot id: A0A0U5AEV3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1653476:THC RS06905
gene id: 1653476:THC_RS06905
uniprot id: A0A0U5AWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1653476:THC RS09070
gene id: 1653476:THC_RS09070
uniprot id: A0A0U4W539
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1653476:THC RS02635
gene id: 1653476:THC_RS02635
uniprot id: A0A0U5AQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1653476:THC RS04650
gene id: 1653476:THC_RS04650
uniprot id: A0A0U5AH99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1653476:THC RS08945
gene id: 1653476:THC_RS08945
uniprot id: A0A0U5AQB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1653476:THC RS07210
gene id: 1653476:THC_RS07210
uniprot id: A0A0U5AIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1653476:THC RS06790
gene id: 1653476:THC_RS06790
uniprot id: A0A0U5AS32
names: Similarity
messages: Belongs to the glutamine synthetase family.

1653476:THC RS08085
gene id: 1653476:THC_RS08085
uniprot id: A0A0U5ASR1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1653476:THC RS08725
gene id: 1653476:THC_RS08725
uniprot id: A0A0U5B1Y8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1653476:THC RS08190
gene id: 1653476:THC_RS08190
uniprot id: A0A0U5B7F2
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1653476:THC RS05300
gene id: 1653476:THC_RS05300
uniprot id: A0A0U5AHS7
names: Similarity
messages: Belongs to the UPF0166 family.

1653476:THC RS06005
gene id: 1653476:THC_RS06005
uniprot id: A0A0U4W3A8
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07780
gene id: 1653476:THC_RS07780
uniprot id: A0A0U4N3R2
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

1653476:THC RS06545
gene id: 1653476:THC_RS06545
uniprot id: A0A0U5AP58
names: Similarity
messages: Belongs to the HdrA family.

1653476:THC RS01035
gene id: 1653476:THC_RS01035
uniprot id: A0A0U5AKJ7
names: Similarity
messages: Belongs to the threonine synthase family.

1653476:THC RS06865
gene id: 1653476:THC_RS06865
uniprot id: A0A0U5B6M8
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Heterodimer of a large and a small subunit.

1653476:THC RS01485
gene id: 1653476:THC_RS01485
uniprot id: A0A0U5AVX5
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS07500
gene id: 1653476:THC_RS07500
uniprot id: A0A0U5AYV8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1653476:THC RS02545
gene id: 1653476:THC_RS02545
uniprot id: A0A0U5AWH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1653476:THC RS01995
gene id: 1653476:THC_RS01995
uniprot id: A0A0U5APN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1653476:THC RS00085
gene id: 1653476:THC_RS00085
uniprot id: A0A0U5AT11
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00150
gene id: 1653476:THC_RS00150
uniprot id: A0A0U5BV28
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS00780
gene id: 1653476:THC_RS00780
uniprot id: A0A0U5AW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1653476:THC RS02405
gene id: 1653476:THC_RS02405
uniprot id: A0A0U5AFU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1653476:THC RS09110
gene id: 1653476:THC_RS09110
uniprot id: A0A0U5AJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1653476:THC RS01435
gene id: 1653476:THC_RS01435
uniprot id: A0A0U5AKS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1653476:THC RS06740
gene id: 1653476:THC_RS06740
uniprot id: A0A0U5AIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1653476:THC RS08515
gene id: 1653476:THC_RS08515
uniprot id: A0A0U5B7K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1653476:THC RS01300
gene id: 1653476:THC_RS01300
uniprot id: A0A0U4W0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

1653476:THC RS08720
gene id: 1653476:THC_RS08720
uniprot id: A0A0U5AXH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1653476:THC RS07555
gene id: 1653476:THC_RS07555
uniprot id: A0A0U5B1D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1653476:THC RS00230
gene id: 1653476:THC_RS00230
uniprot id: A0A0U5BV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1653476:THC RS05105
gene id: 1653476:THC_RS05105
uniprot id: A0A0U5AY61
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1653476:THC RS06055
gene id: 1653476:THC_RS06055
uniprot id: A0A0U5ANE4
names: Similarity
messages: Belongs to the UPF0045 family.

1653476:THC RS02865
gene id: 1653476:THC_RS02865
uniprot id: A0A0U5AWL8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1653476:THC RS05470
gene id: 1653476:THC_RS05470
uniprot id: A0A0U5AHV4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1653476:THC RS07855
gene id: 1653476:THC_RS07855
uniprot id: A0A0U5APB3
names: Similarity
messages: Belongs to the acylphosphatase family.

1653476:THC RS05200
gene id: 1653476:THC_RS05200
uniprot id: A0A0U5B5R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1653476:THC RS06320
gene id: 1653476:THC_RS06320
uniprot id: A0A0U4N2W3
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS04280
gene id: 1653476:THC_RS04280
uniprot id: A0A0U5AQT3
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08385
gene id: 1653476:THC_RS08385
uniprot id: A0A0U5AXB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1653476:THC RS04520
gene id: 1653476:THC_RS04520
uniprot id: A0A0U5AXD0
names: Subcellular Location Annotation
messages: Membrane

1653476:THC RS08995
gene id: 1653476:THC_RS08995
uniprot id: A0A0U5AJS4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1653476:THC RS04340
gene id: 1653476:THC_RS04340
uniprot id: A0A0U4W2F6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1653476:THC RS01850
gene id: 1653476:THC_RS01850
uniprot id: A0A0U5AFK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1653476:THC RS07895
gene id: 1653476:THC_RS07895
uniprot id: A0A0U5AJ52
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1653476:THC RS03405
gene id: 1653476:THC_RS03405
uniprot id: A0A0U5AV07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1653476:THC RS04140
gene id: 1653476:THC_RS04140
uniprot id: A0A0U4N1W1
names: Similarity
messages: Belongs to the UPF0111 family.

1653476:THC RS00185
gene id: 1653476:THC_RS00185
uniprot id: A0A0U5AEK6
names: Similarity
messages: Belongs to the MEMO1 family.