1630135:DAD186 RS01105
gene id: 1630135:DAD186_RS01105
uniprot id: A0A1B0ZFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS09105
gene id: 1630135:DAD186_RS09105
uniprot id: A0A1B0ZKF9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1630135:DAD186 RS04215
gene id: 1630135:DAD186_RS04215
uniprot id: A0A1B0ZHD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.

1630135:DAD186 RS05715
gene id: 1630135:DAD186_RS05715
uniprot id: A0A1B0ZIG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1630135:DAD186 RS02675
gene id: 1630135:DAD186_RS02675
uniprot id: A0A1B0ZGK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1630135:DAD186 RS00025
gene id: 1630135:DAD186_RS00025
uniprot id: A0A1B0ZF49
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1630135:DAD186 RS07575
gene id: 1630135:DAD186_RS07575
uniprot id: A0A1B0ZJM7
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

1630135:DAD186 RS02005
gene id: 1630135:DAD186_RS02005
uniprot id: A0A1B0ZG90
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1630135:DAD186 RS09080
gene id: 1630135:DAD186_RS09080
uniprot id: A0A1B0ZKI8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1630135:DAD186 RS09100
gene id: 1630135:DAD186_RS09100
uniprot id: A0A1B0ZKL7
names: Similarity
messages: Belongs to the PstS family.

1630135:DAD186 RS08100
gene id: 1630135:DAD186_RS08100
uniprot id: A0A1B0ZJM8
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08665
gene id: 1630135:DAD186_RS08665
uniprot id: A0A1B0ZKA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1630135:DAD186 RS00275
gene id: 1630135:DAD186_RS00275
uniprot id: A0A1B0ZFA3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1630135:DAD186 RS08555
gene id: 1630135:DAD186_RS08555
uniprot id: A0A1B0ZJV1
names: Function
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1630135:DAD186 RS04885
gene id: 1630135:DAD186_RS04885
uniprot id: A0A1B0ZHX7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1630135:DAD186 RS08315
gene id: 1630135:DAD186_RS08315
uniprot id: A0A1B0ZJX1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1630135:DAD186 RS10440
gene id: 1630135:DAD186_RS10440
uniprot id: A0A1B0ZKY2
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04365
gene id: 1630135:DAD186_RS04365
uniprot id: A0A1B0ZHN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1630135:DAD186 RS05815
gene id: 1630135:DAD186_RS05815
uniprot id: A0A1B0ZII0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01875
gene id: 1630135:DAD186_RS01875
uniprot id: A0A1B0ZG75
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1630135:DAD186 RS11040
gene id: 1630135:DAD186_RS11040
uniprot id: A0A1B0ZGV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1630135:DAD186 RS04455
gene id: 1630135:DAD186_RS04455
uniprot id: A0A1B0ZHR9
names: Similarity
messages: Belongs to the TlyA family.

1630135:DAD186 RS01765
gene id: 1630135:DAD186_RS01765
uniprot id: A0A1B0ZG46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1630135:DAD186 RS01910
gene id: 1630135:DAD186_RS01910
uniprot id: A0A1B0ZG85
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1630135:DAD186 RS07260
gene id: 1630135:DAD186_RS07260
uniprot id: A0A1B0ZJK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1630135:DAD186 RS01230
gene id: 1630135:DAD186_RS01230
uniprot id: A0A1B0ZFS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

1630135:DAD186 RS08655
gene id: 1630135:DAD186_RS08655
uniprot id: A0A1B0ZK39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1630135:DAD186 RS10370
gene id: 1630135:DAD186_RS10370
uniprot id: A0A1B0ZL49
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

1630135:DAD186 RS08210
gene id: 1630135:DAD186_RS08210
uniprot id: A0A1B0ZJM5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1630135:DAD186 RS04385
gene id: 1630135:DAD186_RS04385
uniprot id: A0A1B0ZHR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1630135:DAD186 RS06240
gene id: 1630135:DAD186_RS06240
uniprot id: A0A1B0ZIK0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1630135:DAD186 RS00610
gene id: 1630135:DAD186_RS00610
uniprot id: A0A1B0ZFH7
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04100
gene id: 1630135:DAD186_RS04100
uniprot id: A0A1B0ZHJ0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS05795
gene id: 1630135:DAD186_RS05795
uniprot id: A0A1B0ZID8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1630135:DAD186 RS07555
gene id: 1630135:DAD186_RS07555
uniprot id: A0A1B0ZJI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

1630135:DAD186 RS10100
gene id: 1630135:DAD186_RS10100
uniprot id: A0A1B0ZKY3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1630135:DAD186 RS01165
gene id: 1630135:DAD186_RS01165
uniprot id: A0A1B0ZFQ8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1630135:DAD186 RS07395
gene id: 1630135:DAD186_RS07395
uniprot id: A0A1B0ZJF7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS07650
gene id: 1630135:DAD186_RS07650
uniprot id: A0A1B0ZJT0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1630135:DAD186 RS05770
gene id: 1630135:DAD186_RS05770
uniprot id: A0A1B0ZIH0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02770
gene id: 1630135:DAD186_RS02770
uniprot id: A0A1B0ZGT9
names: Similarity
messages: Belongs to the GARS family.

1630135:DAD186 RS08250
gene id: 1630135:DAD186_RS08250
uniprot id: A0A1B0ZJY2
names: Similarity
messages: Belongs to the UPF0102 family.

1630135:DAD186 RS06795
gene id: 1630135:DAD186_RS06795
uniprot id: A0A1B0ZJ16
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1630135:DAD186 RS09325
gene id: 1630135:DAD186_RS09325
uniprot id: A0A1B0ZKC4
names: Similarity
messages: Belongs to the peptidase C40 family.

1630135:DAD186 RS02550
gene id: 1630135:DAD186_RS02550
uniprot id: A0A5P2R1T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1630135:DAD186 RS07930
gene id: 1630135:DAD186_RS07930
uniprot id: A0A1B0ZJF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1630135:DAD186 RS04815
gene id: 1630135:DAD186_RS04815
uniprot id: A0A1B0ZHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1630135:DAD186 RS08245
gene id: 1630135:DAD186_RS08245
uniprot id: A0A1B0ZK47
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1630135:DAD186 RS02445
gene id: 1630135:DAD186_RS02445
uniprot id: A0A1B0ZGH2
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

1630135:DAD186 RS10015
gene id: 1630135:DAD186_RS10015
uniprot id: A0A1B0ZL17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS08000
gene id: 1630135:DAD186_RS08000
uniprot id: A0A1B0ZJS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS06820
gene id: 1630135:DAD186_RS06820
uniprot id: A0A1B0ZJ06
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1630135:DAD186 RS03390
gene id: 1630135:DAD186_RS03390
uniprot id: A0A1B0ZH42
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1630135:DAD186 RS05980
gene id: 1630135:DAD186_RS05980
uniprot id: A0A5P2R072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS10410
gene id: 1630135:DAD186_RS10410
uniprot id: A0A1B0ZL30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1630135:DAD186 RS06045
gene id: 1630135:DAD186_RS06045
uniprot id: A0A1B0ZIQ2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1630135:DAD186 RS02680
gene id: 1630135:DAD186_RS02680
uniprot id: A0A1B0ZGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1630135:DAD186 RS05840
gene id: 1630135:DAD186_RS05840
uniprot id: A0A1B0ZIC3
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02545
gene id: 1630135:DAD186_RS02545
uniprot id: A0A1B0ZGI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1630135:DAD186 RS00605
gene id: 1630135:DAD186_RS00605
uniprot id: A0A1B0ZFF8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1630135:DAD186 RS07310
gene id: 1630135:DAD186_RS07310
uniprot id: A0A1B0ZJL3
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS10145
gene id: 1630135:DAD186_RS10145
uniprot id: A0A1B0ZKZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS05755
gene id: 1630135:DAD186_RS05755
uniprot id: A0A5P2R0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1630135:DAD186 RS02000
gene id: 1630135:DAD186_RS02000
uniprot id: A0A1B0ZG89
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1630135:DAD186 RS07860
gene id: 1630135:DAD186_RS07860
uniprot id: A0A1B0ZJM4
names: Similarity
messages: Belongs to the YggT family.

1630135:DAD186 RS01790
gene id: 1630135:DAD186_RS01790
uniprot id: A0A1B0ZG53
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1630135:DAD186 RS07105
gene id: 1630135:DAD186_RS07105
uniprot id: A0A1B0ZJH7
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05120
gene id: 1630135:DAD186_RS05120
uniprot id: A0A1B0ZI48
names: Similarity
messages: Belongs to the glutamine synthetase family.

1630135:DAD186 RS06425
gene id: 1630135:DAD186_RS06425
uniprot id: A0A1B0ZIV3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1630135:DAD186 RS10315
gene id: 1630135:DAD186_RS10315
uniprot id: A0A1B0ZL70
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1630135:DAD186 RS05180
gene id: 1630135:DAD186_RS05180
uniprot id: A0A1B0ZI63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1630135:DAD186 RS06415
gene id: 1630135:DAD186_RS06415
uniprot id: A0A1B0ZIT4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS02620
gene id: 1630135:DAD186_RS02620
uniprot id: A0A1B0ZGR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1630135:DAD186 RS04465
gene id: 1630135:DAD186_RS04465
uniprot id: A0A1B0ZHV4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1630135:DAD186 RS04920
gene id: 1630135:DAD186_RS04920
uniprot id: A0A1B0ZHW2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1630135:DAD186 RS02895
gene id: 1630135:DAD186_RS02895
uniprot id: A0A1B0ZGW9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1630135:DAD186 RS09765
gene id: 1630135:DAD186_RS09765
uniprot id: A0A1B0ZKX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS09950
gene id: 1630135:DAD186_RS09950
uniprot id: A0A1B0ZKX1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS09665
gene id: 1630135:DAD186_RS09665
uniprot id: A0A1B0ZKU9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

1630135:DAD186 RS08300
gene id: 1630135:DAD186_RS08300
uniprot id: A0A1B0ZJZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

1630135:DAD186 RS02625
gene id: 1630135:DAD186_RS02625
uniprot id: A0A1B0ZGK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1630135:DAD186 RS03915
gene id: 1630135:DAD186_RS03915
uniprot id: A0A1B0ZHI2
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1630135:DAD186 RS00995
gene id: 1630135:DAD186_RS00995
uniprot id: A0A1B0ZFP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

1630135:DAD186 RS01510
gene id: 1630135:DAD186_RS01510
uniprot id: A0A1B0ZFZ2
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS07590
gene id: 1630135:DAD186_RS07590
uniprot id: A0A1B0ZJJ5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02540
gene id: 1630135:DAD186_RS02540
uniprot id: A0A1B0ZGJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1630135:DAD186 RS03595
gene id: 1630135:DAD186_RS03595
uniprot id: A0A1B0ZH39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS04225
gene id: 1630135:DAD186_RS04225
uniprot id: A0A1B0ZHN3
names: Similarity
messages: Belongs to the Nth/MutY family.

1630135:DAD186 RS06790
gene id: 1630135:DAD186_RS06790
uniprot id: A0A1B0ZIZ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1630135:DAD186 RS03360
gene id: 1630135:DAD186_RS03360
uniprot id: A0A1B0ZGY9
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1630135:DAD186 RS00365
gene id: 1630135:DAD186_RS00365
uniprot id: A0A1B0ZFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1630135:DAD186 RS08305
gene id: 1630135:DAD186_RS08305
uniprot id: A0A1B0ZJP8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1630135:DAD186 RS04930
gene id: 1630135:DAD186_RS04930
uniprot id: A0A1B0ZHZ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1630135:DAD186 RS09340
gene id: 1630135:DAD186_RS09340
uniprot id: A0A1B0ZKA4
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

1630135:DAD186 RS05570
gene id: 1630135:DAD186_RS05570
uniprot id: A0A1B0ZIC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS02510
gene id: 1630135:DAD186_RS02510
uniprot id: A0A1B0ZGM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1630135:DAD186 RS00820
gene id: 1630135:DAD186_RS00820
uniprot id: A0A1B0ZFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS01625
gene id: 1630135:DAD186_RS01625
uniprot id: A0A1B0ZG15
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01200
gene id: 1630135:DAD186_RS01200
uniprot id: A0A1B0ZFW0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1630135:DAD186 RS09805
gene id: 1630135:DAD186_RS09805
uniprot id: A0A1B0ZKK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS01860
gene id: 1630135:DAD186_RS01860
uniprot id: A0A1B0ZG62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS08890
gene id: 1630135:DAD186_RS08890
uniprot id: A0A1B0ZKH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS05610
gene id: 1630135:DAD186_RS05610
uniprot id: A0A1B0ZI85
names: Similarity
messages: Belongs to the UPF0098 family.

1630135:DAD186 RS05640
gene id: 1630135:DAD186_RS05640
uniprot id: A0A1B0ZI82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1630135:DAD186 RS05305
gene id: 1630135:DAD186_RS05305
uniprot id: A0A1B0ZI95
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1630135:DAD186 RS07265
gene id: 1630135:DAD186_RS07265
uniprot id: A0A1B0ZJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1630135:DAD186 RS05560
gene id: 1630135:DAD186_RS05560
uniprot id: A0A1B0ZI76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1630135:DAD186 RS00370
gene id: 1630135:DAD186_RS00370
uniprot id: A0A1B0ZFC3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1630135:DAD186 RS07895
gene id: 1630135:DAD186_RS07895
uniprot id: A0A1B0ZJT6
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02565
gene id: 1630135:DAD186_RS02565
uniprot id: A0A1B0ZGP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1630135:DAD186 RS01150
gene id: 1630135:DAD186_RS01150
uniprot id: A0A1B0ZFU5
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

1630135:DAD186 RS10020
gene id: 1630135:DAD186_RS10020
uniprot id: A0A1B0ZL21
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08095
gene id: 1630135:DAD186_RS08095
uniprot id: A0A1B0ZJU8
names: Similarity
messages: Belongs to the peptidase M16 family.

1630135:DAD186 RS02760
gene id: 1630135:DAD186_RS02760
uniprot id: A0A1B0ZGS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS00805
gene id: 1630135:DAD186_RS00805
uniprot id: A0A1B0ZFL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1630135:DAD186 RS01750
gene id: 1630135:DAD186_RS01750
uniprot id: A0A1B0ZG44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1630135:DAD186 RS04825
gene id: 1630135:DAD186_RS04825
uniprot id: A0A1B0ZHT7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1630135:DAD186 RS06215
gene id: 1630135:DAD186_RS06215
uniprot id: A0A1B0ZIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1630135:DAD186 RS08885
gene id: 1630135:DAD186_RS08885
uniprot id: A0A1B0ZK32
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS07270
gene id: 1630135:DAD186_RS07270
uniprot id: A0A1B0ZJ46
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1630135:DAD186 RS09780
gene id: 1630135:DAD186_RS09780
uniprot id: A0A1B0ZKS7
names: Similarity
messages: Belongs to the DapA family.

1630135:DAD186 RS07445
gene id: 1630135:DAD186_RS07445
uniprot id: A0A1B0ZJG7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1630135:DAD186 RS02130
gene id: 1630135:DAD186_RS02130
uniprot id: A0A1B0ZGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS01375
gene id: 1630135:DAD186_RS01375
uniprot id: A0A1B0ZFV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS02330
gene id: 1630135:DAD186_RS02330
uniprot id: A0A1B0ZGJ3
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1630135:DAD186 RS03845
gene id: 1630135:DAD186_RS03845
uniprot id: A0A1B0ZHD2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1630135:DAD186 RS02615
gene id: 1630135:DAD186_RS02615
uniprot id: A0A1B0ZGS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1630135:DAD186 RS01915
gene id: 1630135:DAD186_RS01915
uniprot id: A0A1B0ZG87
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS07250
gene id: 1630135:DAD186_RS07250
uniprot id: A0A1B0ZJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1630135:DAD186 RS06170
gene id: 1630135:DAD186_RS06170
uniprot id: A0A1B0ZIP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1630135:DAD186 RS05440
gene id: 1630135:DAD186_RS05440
uniprot id: A0A1B0ZI70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1630135:DAD186 RS07600
gene id: 1630135:DAD186_RS07600
uniprot id: A0A1B0ZJS1
names: Similarity
messages: Belongs to the BMP lipoprotein family.

1630135:DAD186 RS04295
gene id: 1630135:DAD186_RS04295
uniprot id: A0A1B0ZHS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

1630135:DAD186 RS09255
gene id: 1630135:DAD186_RS09255
uniprot id: A0A1B0ZK86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1630135:DAD186 RS10490
gene id: 1630135:DAD186_RS10490
uniprot id: A0A1B0ZL81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1630135:DAD186 RS09695
gene id: 1630135:DAD186_RS09695
uniprot id: A0A1B0ZKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1630135:DAD186 RS03925
gene id: 1630135:DAD186_RS03925
uniprot id: A0A1B0ZHA5
names: Similarity
messages: Belongs to the creatininase superfamily.

1630135:DAD186 RS04130
gene id: 1630135:DAD186_RS04130
uniprot id: A0A1B0ZHJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1630135:DAD186 RS00380
gene id: 1630135:DAD186_RS00380
uniprot id: A0A1B0ZFA7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1630135:DAD186 RS10345
gene id: 1630135:DAD186_RS10345
uniprot id: A0A1B0ZL65
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02045
gene id: 1630135:DAD186_RS02045
uniprot id: A0A1B0ZGB1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01955
gene id: 1630135:DAD186_RS01955
uniprot id: A0A1B0ZG79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1630135:DAD186 RS06400
gene id: 1630135:DAD186_RS06400
uniprot id: A0A1B0ZIN4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1630135:DAD186 RS06165
gene id: 1630135:DAD186_RS06165
uniprot id: A0A1B0ZIP8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1630135:DAD186 RS01530
gene id: 1630135:DAD186_RS01530
uniprot id: A0A1B0ZFZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1630135:DAD186 RS07720
gene id: 1630135:DAD186_RS07720
uniprot id: A0A1B0ZJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS05510
gene id: 1630135:DAD186_RS05510
uniprot id: A0A1B0ZIA1
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

1630135:DAD186 RS06625
gene id: 1630135:DAD186_RS06625
uniprot id: A0A1B0ZJ98
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05820
gene id: 1630135:DAD186_RS05820
uniprot id: A0A1B0ZIH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1630135:DAD186 RS02710
gene id: 1630135:DAD186_RS02710
uniprot id: A0A1B0ZGR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1630135:DAD186 RS09485
gene id: 1630135:DAD186_RS09485
uniprot id: A0A1B0ZKN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS03565
gene id: 1630135:DAD186_RS03565
uniprot id: A0A1B0ZHA7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1630135:DAD186 RS04355
gene id: 1630135:DAD186_RS04355
uniprot id: A0A1B0ZHJ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS00385
gene id: 1630135:DAD186_RS00385
uniprot id: A0A1B0ZFB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS07765
gene id: 1630135:DAD186_RS07765
uniprot id: A0A1B0ZJK6
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

1630135:DAD186 RS07865
gene id: 1630135:DAD186_RS07865
uniprot id: A0A1B0ZJP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1630135:DAD186 RS03955
gene id: 1630135:DAD186_RS03955
uniprot id: A0A1B0ZHH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

1630135:DAD186 RS08710
gene id: 1630135:DAD186_RS08710
uniprot id: A0A1B0ZKC1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1630135:DAD186 RS06180
gene id: 1630135:DAD186_RS06180
uniprot id: A0A1B0ZIQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1630135:DAD186 RS10330
gene id: 1630135:DAD186_RS10330
uniprot id: A0A1B0ZKW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS07630
gene id: 1630135:DAD186_RS07630
uniprot id: A0A1B0ZJP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS10170
gene id: 1630135:DAD186_RS10170
uniprot id: A0A5P2QY29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

1630135:DAD186 RS09475
gene id: 1630135:DAD186_RS09475
uniprot id: A0A1B0ZKF5
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1630135:DAD186 RS02775
gene id: 1630135:DAD186_RS02775
uniprot id: A0A1B0ZGM1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS07695
gene id: 1630135:DAD186_RS07695
uniprot id: A0A1B0ZJQ6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1630135:DAD186 RS07740
gene id: 1630135:DAD186_RS07740
uniprot id: A0A1B0ZJM3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1630135:DAD186 RS10265
gene id: 1630135:DAD186_RS10265
uniprot id: A0A1B0ZL68
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04320
gene id: 1630135:DAD186_RS04320
uniprot id: A0A1B0ZHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1630135:DAD186 RS06325
gene id: 1630135:DAD186_RS06325
uniprot id: A0A1B0ZIT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS03370
gene id: 1630135:DAD186_RS03370
uniprot id: A0A1B0ZH45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS06590
gene id: 1630135:DAD186_RS06590
uniprot id: A0A1B0ZIU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1630135:DAD186 RS06335
gene id: 1630135:DAD186_RS06335
uniprot id: A0A1B0ZJ47
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1630135:DAD186 RS05830
gene id: 1630135:DAD186_RS05830
uniprot id: A0A1B0ZII2
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1630135:DAD186 RS09060
gene id: 1630135:DAD186_RS09060
uniprot id: A0A1B0ZK46
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1630135:DAD186 RS10060
gene id: 1630135:DAD186_RS10060
uniprot id: A0A1B0ZL26
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1630135:DAD186 RS03670
gene id: 1630135:DAD186_RS03670
uniprot id: A0A1B0ZH57
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

1630135:DAD186 RS03695
gene id: 1630135:DAD186_RS03695
uniprot id: A0A1B0ZHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

1630135:DAD186 RS03950
gene id: 1630135:DAD186_RS03950
uniprot id: A0A1B0ZHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS07585
gene id: 1630135:DAD186_RS07585
uniprot id: A0A1B0ZJH5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS00110
gene id: 1630135:DAD186_RS00110
uniprot id: A0A1B0ZF65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS01795
gene id: 1630135:DAD186_RS01795
uniprot id: A0A1B0ZG48
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02300
gene id: 1630135:DAD186_RS02300
uniprot id: A0A1B0ZGG1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01270
gene id: 1630135:DAD186_RS01270
uniprot id: A0A1B0ZFT9
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04230
gene id: 1630135:DAD186_RS04230
uniprot id: A0A1B0ZHG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1630135:DAD186 RS04240
gene id: 1630135:DAD186_RS04240
uniprot id: A0A1B0ZHM0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1630135:DAD186 RS00935
gene id: 1630135:DAD186_RS00935
uniprot id: A0A1B0ZFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS03300
gene id: 1630135:DAD186_RS03300
uniprot id: A0A1B0ZH29
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS10240
gene id: 1630135:DAD186_RS10240
uniprot id: A0A1B0ZL55
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05005
gene id: 1630135:DAD186_RS05005
uniprot id: A0A1B0ZHZ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1630135:DAD186 RS09075
gene id: 1630135:DAD186_RS09075
uniprot id: A0A1B0ZKH7
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS03875
gene id: 1630135:DAD186_RS03875
uniprot id: A0A1B0ZH96
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1630135:DAD186 RS09480
gene id: 1630135:DAD186_RS09480
uniprot id: A0A1B0ZKU0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1630135:DAD186 RS08125
gene id: 1630135:DAD186_RS08125
uniprot id: A0A1B0ZJS8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1630135:DAD186 RS10765
gene id: 1630135:DAD186_RS10765
uniprot id: A0A1B0ZFJ5
names: Similarity
messages: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.

1630135:DAD186 RS04700
gene id: 1630135:DAD186_RS04700
uniprot id: A0A1B0ZHN9
names: Similarity
messages: Belongs to the UDPGP type 1 family.

1630135:DAD186 RS00965
gene id: 1630135:DAD186_RS00965
uniprot id: A0A1B0ZFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1630135:DAD186 RS09875
gene id: 1630135:DAD186_RS09875
uniprot id: A0A1B0ZKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1630135:DAD186 RS06040
gene id: 1630135:DAD186_RS06040
uniprot id: A0A1B0ZIJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS08660
gene id: 1630135:DAD186_RS08660
uniprot id: A0A1B0ZK98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

1630135:DAD186 RS10350
gene id: 1630135:DAD186_RS10350
uniprot id: A0A1B0ZL23
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1630135:DAD186 RS08870
gene id: 1630135:DAD186_RS08870
uniprot id: A0A1B0ZKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS02765
gene id: 1630135:DAD186_RS02765
uniprot id: A0A1B0ZGU9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1630135:DAD186 RS08575
gene id: 1630135:DAD186_RS08575
uniprot id: A0A1B0ZK20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1630135:DAD186 RS07800
gene id: 1630135:DAD186_RS07800
uniprot id: A0A1B0ZJK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1630135:DAD186 RS00700
gene id: 1630135:DAD186_RS00700
uniprot id: A0A1B0ZFI2
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05135
gene id: 1630135:DAD186_RS05135
uniprot id: A0A1B0ZI53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1630135:DAD186 RS07785
gene id: 1630135:DAD186_RS07785
uniprot id: A0A1B0ZJN5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1630135:DAD186 RS05660
gene id: 1630135:DAD186_RS05660
uniprot id: A0A1B0ZIE9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1630135:DAD186 RS05280
gene id: 1630135:DAD186_RS05280
uniprot id: A0A1B0ZIF7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

1630135:DAD186 RS01175
gene id: 1630135:DAD186_RS01175
uniprot id: A0A1B0ZFS5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1630135:DAD186 RS00845
gene id: 1630135:DAD186_RS00845
uniprot id: A0A1B0ZFL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1630135:DAD186 RS04620
gene id: 1630135:DAD186_RS04620
uniprot id: A0A1B0ZHN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS02915
gene id: 1630135:DAD186_RS02915
uniprot id: A0A1B0ZGQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

1630135:DAD186 RS05300
gene id: 1630135:DAD186_RS05300
uniprot id: A0A1B0ZI43
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1630135:DAD186 RS07450
gene id: 1630135:DAD186_RS07450
uniprot id: A0A1B0ZJB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS02560
gene id: 1630135:DAD186_RS02560
uniprot id: A0A1B0ZGJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1630135:DAD186 RS05055
gene id: 1630135:DAD186_RS05055
uniprot id: A0A1B0ZI12
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1630135:DAD186 RS09755
gene id: 1630135:DAD186_RS09755
uniprot id: A0A1B0ZKJ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1630135:DAD186 RS09760
gene id: 1630135:DAD186_RS09760
uniprot id: A0A1B0ZKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS04905
gene id: 1630135:DAD186_RS04905
uniprot id: A0A1B0ZI02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS07815
gene id: 1630135:DAD186_RS07815
uniprot id: A0A1B0ZJL6
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04270
gene id: 1630135:DAD186_RS04270
uniprot id: A0A1B0ZHP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

1630135:DAD186 RS08770
gene id: 1630135:DAD186_RS08770
uniprot id: A0A1B0ZKF2
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1630135:DAD186 RS10275
gene id: 1630135:DAD186_RS10275
uniprot id: A0A1B0ZKV5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1630135:DAD186 RS05335
gene id: 1630135:DAD186_RS05335
uniprot id: A0A1B0ZI90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1630135:DAD186 RS05255
gene id: 1630135:DAD186_RS05255
uniprot id: A0A1B0ZI86
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

1630135:DAD186 RS10990
gene id: 1630135:DAD186_RS10990
uniprot id: A0A1B0ZJW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1630135:DAD186 RS03025
gene id: 1630135:DAD186_RS03025
uniprot id: A0A1B0ZGS5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1630135:DAD186 RS02490
gene id: 1630135:DAD186_RS02490
uniprot id: A0A1B0ZGP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1630135:DAD186 RS05310
gene id: 1630135:DAD186_RS05310
uniprot id: A0A1B0ZI65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1630135:DAD186 RS08275
gene id: 1630135:DAD186_RS08275
uniprot id: A0A1B0ZK26
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1630135:DAD186 RS09910
gene id: 1630135:DAD186_RS09910
uniprot id: A0A1B0ZKM0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS06015
gene id: 1630135:DAD186_RS06015
uniprot id: A0A1B0ZIM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1630135:DAD186 RS05525
gene id: 1630135:DAD186_RS05525
uniprot id: A0A1B0ZIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1630135:DAD186 RS00940
gene id: 1630135:DAD186_RS00940
uniprot id: A0A1B0ZFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS05625
gene id: 1630135:DAD186_RS05625
uniprot id: A0A1B0ZIM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1630135:DAD186 RS04835
gene id: 1630135:DAD186_RS04835
uniprot id: A0A1B0ZHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1630135:DAD186 RS06160
gene id: 1630135:DAD186_RS06160
uniprot id: A0A1B0ZIJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS03470
gene id: 1630135:DAD186_RS03470
uniprot id: A0A1B0ZH94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1630135:DAD186 RS02785
gene id: 1630135:DAD186_RS02785
uniprot id: A0A1B0ZGS7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1630135:DAD186 RS05575
gene id: 1630135:DAD186_RS05575
uniprot id: A0A1B0ZIL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1630135:DAD186 RS01935
gene id: 1630135:DAD186_RS01935
uniprot id: A0A1B0ZG66
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1630135:DAD186 RS07380
gene id: 1630135:DAD186_RS07380
uniprot id: A0A1B0ZJI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1630135:DAD186 RS02580
gene id: 1630135:DAD186_RS02580
uniprot id: A0A1B0ZGQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1630135:DAD186 RS08140
gene id: 1630135:DAD186_RS08140
uniprot id: A0A1B0ZJT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1630135:DAD186 RS09600
gene id: 1630135:DAD186_RS09600
uniprot id: A0A1B0ZKN6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1630135:DAD186 RS04530
gene id: 1630135:DAD186_RS04530
uniprot id: A0A1B0ZHK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1630135:DAD186 RS02700
gene id: 1630135:DAD186_RS02700
uniprot id: A0A1B0ZGK7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1630135:DAD186 RS01015
gene id: 1630135:DAD186_RS01015
uniprot id: A0A1B0ZFP1
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1630135:DAD186 RS08285
gene id: 1630135:DAD186_RS08285
uniprot id: A0A1B0ZJY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1630135:DAD186 RS10175
gene id: 1630135:DAD186_RS10175
uniprot id: A0A1B0ZL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1630135:DAD186 RS00310
gene id: 1630135:DAD186_RS00310
uniprot id: A0A1B0ZFB3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1630135:DAD186 RS01490
gene id: 1630135:DAD186_RS01490
uniprot id: A0A1B0ZFZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1630135:DAD186 RS08470
gene id: 1630135:DAD186_RS08470
uniprot id: A0A1B0ZK64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1630135:DAD186 RS06290
gene id: 1630135:DAD186_RS06290
uniprot id: A0A1B0ZIK9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1630135:DAD186 RS05540
gene id: 1630135:DAD186_RS05540
uniprot id: A0A1B0ZI64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1630135:DAD186 RS05995
gene id: 1630135:DAD186_RS05995
uniprot id: A0A1B0ZII1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS03880
gene id: 1630135:DAD186_RS03880
uniprot id: A0A1B0ZH69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1630135:DAD186 RS10045
gene id: 1630135:DAD186_RS10045
uniprot id: A0A1B0ZKQ5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01850
gene id: 1630135:DAD186_RS01850
uniprot id: A0A1B0ZG73
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02505
gene id: 1630135:DAD186_RS02505
uniprot id: A0A1B0ZGL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1630135:DAD186 RS03030
gene id: 1630135:DAD186_RS03030
uniprot id: A0A1B0ZGQ5
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Tetramer of two alpha and two beta subunits.

1630135:DAD186 RS06450
gene id: 1630135:DAD186_RS06450
uniprot id: A0A1B0ZIP2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1630135:DAD186 RS07430
gene id: 1630135:DAD186_RS07430
uniprot id: A0A1B0ZJJ2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1630135:DAD186 RS02400
gene id: 1630135:DAD186_RS02400
uniprot id: A0A1B0ZGH9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1630135:DAD186 RS10205
gene id: 1630135:DAD186_RS10205
uniprot id: A0A1B0ZKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS03840
gene id: 1630135:DAD186_RS03840
uniprot id: A0A1B0ZHF8
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS03825
gene id: 1630135:DAD186_RS03825
uniprot id: A0A1B0ZH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1630135:DAD186 RS09735
gene id: 1630135:DAD186_RS09735
uniprot id: A0A1B0ZKK2
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1630135:DAD186 RS02115
gene id: 1630135:DAD186_RS02115
uniprot id: A0A1B0ZGC5
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1630135:DAD186 RS08070
gene id: 1630135:DAD186_RS08070
uniprot id: A0A1B0ZJJ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

1630135:DAD186 RS04045
gene id: 1630135:DAD186_RS04045
uniprot id: A0A1B0ZHC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1630135:DAD186 RS02690
gene id: 1630135:DAD186_RS02690
uniprot id: A0A1B0ZGR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1630135:DAD186 RS03985
gene id: 1630135:DAD186_RS03985
uniprot id: A0A1B0ZHF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1630135:DAD186 RS00665
gene id: 1630135:DAD186_RS00665
uniprot id: A0A1B0ZFG5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS09020
gene id: 1630135:DAD186_RS09020
uniprot id: A0A1B0ZKB3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1630135:DAD186 RS01940
gene id: 1630135:DAD186_RS01940
uniprot id: A0A1B0ZG78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS07325
gene id: 1630135:DAD186_RS07325
uniprot id: A0A1B0ZJ44
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1630135:DAD186 RS01145
gene id: 1630135:DAD186_RS01145
uniprot id: A0A1B0ZFT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS09445
gene id: 1630135:DAD186_RS09445
uniprot id: A0A1B0ZKC9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1630135:DAD186 RS08195
gene id: 1630135:DAD186_RS08195
uniprot id: A0A1B0ZK38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1630135:DAD186 RS09605
gene id: 1630135:DAD186_RS09605
uniprot id: A0A1B0ZKT6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.
messages: Belongs to the fatty acyl-CoA reductase family.

1630135:DAD186 RS04520
gene id: 1630135:DAD186_RS04520
uniprot id: A0A1B0ZHU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1630135:DAD186 RS09820
gene id: 1630135:DAD186_RS09820
uniprot id: A0A1B0ZKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1630135:DAD186 RS03860
gene id: 1630135:DAD186_RS03860
uniprot id: A0A1B0ZHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS03365
gene id: 1630135:DAD186_RS03365
uniprot id: A0A1B0ZH58
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS03535
gene id: 1630135:DAD186_RS03535
uniprot id: A0A1B0ZGZ7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1630135:DAD186 RS02665
gene id: 1630135:DAD186_RS02665
uniprot id: A0A1B0ZGT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1630135:DAD186 RS08330
gene id: 1630135:DAD186_RS08330
uniprot id: A0A1B0ZJX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1630135:DAD186 RS03730
gene id: 1630135:DAD186_RS03730
uniprot id: A0A1B0ZH35
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1630135:DAD186 RS04570
gene id: 1630135:DAD186_RS04570
uniprot id: A0A1B0ZHM6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS06455
gene id: 1630135:DAD186_RS06455
uniprot id: A0A1B0ZIR7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1630135:DAD186 RS04410
gene id: 1630135:DAD186_RS04410
uniprot id: A0A1B0ZHI1
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS02570
gene id: 1630135:DAD186_RS02570
uniprot id: A0A1B0ZGN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1630135:DAD186 RS05985
gene id: 1630135:DAD186_RS05985
uniprot id: A0A1B0ZII4
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1630135:DAD186 RS06440
gene id: 1630135:DAD186_RS06440
uniprot id: A0A1B0ZIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS05445
gene id: 1630135:DAD186_RS05445
uniprot id: A0A1B0ZI45
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08060
gene id: 1630135:DAD186_RS08060
uniprot id: A0A1B0ZJU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1630135:DAD186 RS08785
gene id: 1630135:DAD186_RS08785
uniprot id: A0A1B0ZJZ7
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1630135:DAD186 RS06285
gene id: 1630135:DAD186_RS06285
uniprot id: A0A1B0ZIP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1630135:DAD186 RS08880
gene id: 1630135:DAD186_RS08880
uniprot id: A0A1B0ZKA1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08905
gene id: 1630135:DAD186_RS08905
uniprot id: A0A1B0ZK18
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS05365
gene id: 1630135:DAD186_RS05365
uniprot id: A0A1B0ZI39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

1630135:DAD186 RS03820
gene id: 1630135:DAD186_RS03820
uniprot id: A0A1B0ZHF7
names: Similarity
messages: Belongs to the peptidase M13 family.

1630135:DAD186 RS02310
gene id: 1630135:DAD186_RS02310
uniprot id: A0A1B0ZGH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1630135:DAD186 RS01215
gene id: 1630135:DAD186_RS01215
uniprot id: A0A1B0ZFR8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1630135:DAD186 RS05330
gene id: 1630135:DAD186_RS05330
uniprot id: A0A1B0ZIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1630135:DAD186 RS07580
gene id: 1630135:DAD186_RS07580
uniprot id: A0A1B0ZJN6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1630135:DAD186 RS01740
gene id: 1630135:DAD186_RS01740
uniprot id: A0A1B0ZG61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

1630135:DAD186 RS05190
gene id: 1630135:DAD186_RS05190
uniprot id: A0A5P2R340
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1630135:DAD186 RS05150
gene id: 1630135:DAD186_RS05150
uniprot id: A0A1B0ZI13
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1630135:DAD186 RS08840
gene id: 1630135:DAD186_RS08840
uniprot id: A0A1B0ZK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1630135:DAD186 RS01320
gene id: 1630135:DAD186_RS01320
uniprot id: A0A1B0ZFV7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1630135:DAD186 RS01380
gene id: 1630135:DAD186_RS01380
uniprot id: A0A1B0ZFW1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS06645
gene id: 1630135:DAD186_RS06645
uniprot id: A0A1B0ZIW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1630135:DAD186 RS09040
gene id: 1630135:DAD186_RS09040
uniprot id: A0A1B0ZKC6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

1630135:DAD186 RS06265
gene id: 1630135:DAD186_RS06265
uniprot id: A0A1B0ZIR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1630135:DAD186 RS09330
gene id: 1630135:DAD186_RS09330
uniprot id: A0A1B0ZKR0
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1630135:DAD186 RS01330
gene id: 1630135:DAD186_RS01330
uniprot id: A0A1B0ZFV0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01285
gene id: 1630135:DAD186_RS01285
uniprot id: A0A1B0ZFT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS08395
gene id: 1630135:DAD186_RS08395
uniprot id: A0A1B0ZK15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1630135:DAD186 RS05460
gene id: 1630135:DAD186_RS05460
uniprot id: A0A1B0ZI93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1630135:DAD186 RS05615
gene id: 1630135:DAD186_RS05615
uniprot id: A0A1B0ZID7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1630135:DAD186 RS02370
gene id: 1630135:DAD186_RS02370
uniprot id: A0A1B0ZGG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1630135:DAD186 RS04020
gene id: 1630135:DAD186_RS04020
uniprot id: A0A1B0ZHJ5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1630135:DAD186 RS07935
gene id: 1630135:DAD186_RS07935
uniprot id: A0A5P2R471
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1630135:DAD186 RS02780
gene id: 1630135:DAD186_RS02780
uniprot id: A0A1B0ZGL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1630135:DAD186 RS06575
gene id: 1630135:DAD186_RS06575
uniprot id: A0A1B0ZIX8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1630135:DAD186 RS07855
gene id: 1630135:DAD186_RS07855
uniprot id: A0A1B0ZJT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1630135:DAD186 RS07825
gene id: 1630135:DAD186_RS07825
uniprot id: A0A1B0ZJG9
names: Similarity
messages: Belongs to the HisA/HisF family.

1630135:DAD186 RS06010
gene id: 1630135:DAD186_RS06010
uniprot id: A0A1B0ZIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1630135:DAD186 RS07200
gene id: 1630135:DAD186_RS07200
uniprot id: A0A1B0ZJC4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1630135:DAD186 RS03655
gene id: 1630135:DAD186_RS03655
uniprot id: A0A1B0ZHA4
names: Similarity
messages: Belongs to the peptidase M1 family.

1630135:DAD186 RS09030
gene id: 1630135:DAD186_RS09030
uniprot id: A0A1B0ZKH8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1630135:DAD186 RS00570
gene id: 1630135:DAD186_RS00570
uniprot id: A0A1B0ZFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1630135:DAD186 RS01450
gene id: 1630135:DAD186_RS01450
uniprot id: A0A1B0ZFZ8
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1630135:DAD186 RS07560
gene id: 1630135:DAD186_RS07560
uniprot id: A0A1B0ZJA6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1630135:DAD186 RS04715
gene id: 1630135:DAD186_RS04715
uniprot id: A0A1B0ZHV2
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS06445
gene id: 1630135:DAD186_RS06445
uniprot id: A0A1B0ZIS1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1630135:DAD186 RS10505
gene id: 1630135:DAD186_RS10505
uniprot id: A0A1B0ZL57
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1630135:DAD186 RS07160
gene id: 1630135:DAD186_RS07160
uniprot id: A0A1B0ZJI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1630135:DAD186 RS08465
gene id: 1630135:DAD186_RS08465
uniprot id: A0A1B0ZK58
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1630135:DAD186 RS08410
gene id: 1630135:DAD186_RS08410
uniprot id: A0A1B0ZK44
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

1630135:DAD186 RS01680
gene id: 1630135:DAD186_RS01680
uniprot id: A0A1B0ZG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS05780
gene id: 1630135:DAD186_RS05780
uniprot id: A0A1B0ZIH3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1630135:DAD186 RS01690
gene id: 1630135:DAD186_RS01690
uniprot id: A0A1B0ZG34
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1630135:DAD186 RS02495
gene id: 1630135:DAD186_RS02495
uniprot id: A0A1B0ZGN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1630135:DAD186 RS03990
gene id: 1630135:DAD186_RS03990
uniprot id: A0A1B0ZHI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1630135:DAD186 RS03080
gene id: 1630135:DAD186_RS03080
uniprot id: A0A1B0ZGT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1630135:DAD186 RS02335
gene id: 1630135:DAD186_RS02335
uniprot id: A0A1B0ZGJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1630135:DAD186 RS04850
gene id: 1630135:DAD186_RS04850
uniprot id: A0A1B0ZHT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1630135:DAD186 RS05235
gene id: 1630135:DAD186_RS05235
uniprot id: A0A1B0ZI71
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS04610
gene id: 1630135:DAD186_RS04610
uniprot id: A0A1B0ZHV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1630135:DAD186 RS07215
gene id: 1630135:DAD186_RS07215
uniprot id: A0A1B0ZJC8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

1630135:DAD186 RS09205
gene id: 1630135:DAD186_RS09205
uniprot id: A0A1B0ZK77
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1630135:DAD186 RS09565
gene id: 1630135:DAD186_RS09565
uniprot id: A0A1B0ZKN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1630135:DAD186 RS07130
gene id: 1630135:DAD186_RS07130
uniprot id: A0A1B0ZJ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1630135:DAD186 RS06225
gene id: 1630135:DAD186_RS06225
uniprot id: A0A1B0ZJ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1630135:DAD186 RS08360
gene id: 1630135:DAD186_RS08360
uniprot id: A0A1B0ZJY0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08065
gene id: 1630135:DAD186_RS08065
uniprot id: A0A1B0ZJJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1630135:DAD186 RS02530
gene id: 1630135:DAD186_RS02530
uniprot id: A0A1B0ZGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1630135:DAD186 RS06585
gene id: 1630135:DAD186_RS06585
uniprot id: A0A1B0ZIY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1630135:DAD186 RS02010
gene id: 1630135:DAD186_RS02010
uniprot id: A0A1B0ZGA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1630135:DAD186 RS10415
gene id: 1630135:DAD186_RS10415
uniprot id: A0A1B0ZL43
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS01480
gene id: 1630135:DAD186_RS01480
uniprot id: A0A1B0ZFY1
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1630135:DAD186 RS04695
gene id: 1630135:DAD186_RS04695
uniprot id: A0A1B0ZHQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1630135:DAD186 RS05030
gene id: 1630135:DAD186_RS05030
uniprot id: A0A1B0ZI37
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1630135:DAD186 RS05925
gene id: 1630135:DAD186_RS05925
uniprot id: A0A1B0ZIT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1630135:DAD186 RS05465
gene id: 1630135:DAD186_RS05465
uniprot id: A0A1B0ZI59
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1630135:DAD186 RS03705
gene id: 1630135:DAD186_RS03705
uniprot id: A0A1B0ZHC6
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS07210
gene id: 1630135:DAD186_RS07210
uniprot id: A0A1B0ZJJ6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1630135:DAD186 RS08930
gene id: 1630135:DAD186_RS08930
uniprot id: A0A1B0ZK88
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1630135:DAD186 RS10480
gene id: 1630135:DAD186_RS10480
uniprot id: A0A1B0ZKZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1630135:DAD186 RS01675
gene id: 1630135:DAD186_RS01675
uniprot id: A0A1B0ZG25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS05580
gene id: 1630135:DAD186_RS05580
uniprot id: A0A1B0ZID4
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1630135:DAD186 RS00015
gene id: 1630135:DAD186_RS00015
uniprot id: A0A1B0ZF43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1630135:DAD186 RS04145
gene id: 1630135:DAD186_RS04145
uniprot id: A0A5P2R850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1630135:DAD186 RS08970
gene id: 1630135:DAD186_RS08970
uniprot id: A0A1B0ZKA3
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS08015
gene id: 1630135:DAD186_RS08015
uniprot id: A0A1B0ZJT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS02430
gene id: 1630135:DAD186_RS02430
uniprot id: A0A1B0ZGF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1630135:DAD186 RS01075
gene id: 1630135:DAD186_RS01075
uniprot id: A0A1B0ZFQ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

1630135:DAD186 RS00695
gene id: 1630135:DAD186_RS00695
uniprot id: A0A1B0ZFI1
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1630135:DAD186 RS07405
gene id: 1630135:DAD186_RS07405
uniprot id: A0A1B0ZJN2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1630135:DAD186 RS04310
gene id: 1630135:DAD186_RS04310
uniprot id: A0A1B0ZHG0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1630135:DAD186 RS03515
gene id: 1630135:DAD186_RS03515
uniprot id: A0A1B0ZH70
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1630135:DAD186 RS01430
gene id: 1630135:DAD186_RS01430
uniprot id: A0A1B0ZFX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1630135:DAD186 RS01205
gene id: 1630135:DAD186_RS01205
uniprot id: A0A1B0ZFU6
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1630135:DAD186 RS02855
gene id: 1630135:DAD186_RS02855
uniprot id: A0A1B0ZGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1630135:DAD186 RS07625
gene id: 1630135:DAD186_RS07625
uniprot id: A0A1B0ZJN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1630135:DAD186 RS04670
gene id: 1630135:DAD186_RS04670
uniprot id: A0A1B0ZHP7
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1630135:DAD186 RS03375
gene id: 1630135:DAD186_RS03375
uniprot id: A0A1B0ZH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1630135:DAD186 RS07890
gene id: 1630135:DAD186_RS07890
uniprot id: A0A1B0ZJM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS01975
gene id: 1630135:DAD186_RS01975
uniprot id: A0A1B0ZGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1630135:DAD186 RS00755
gene id: 1630135:DAD186_RS00755
uniprot id: A0A1B0ZFJ1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1630135:DAD186 RS01135
gene id: 1630135:DAD186_RS01135
uniprot id: A0A1B0ZFS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1630135:DAD186 RS06300
gene id: 1630135:DAD186_RS06300
uniprot id: A0A1B0ZIV2
names: Similarity
messages: Belongs to the universal stress protein A family.

1630135:DAD186 RS02945
gene id: 1630135:DAD186_RS02945
uniprot id: A0A1B0ZGY0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1630135:DAD186 RS05070
gene id: 1630135:DAD186_RS05070
uniprot id: A0A1B0ZI30
names: Similarity
messages: Belongs to the peptidase S66 family.

1630135:DAD186 RS02735
gene id: 1630135:DAD186_RS02735
uniprot id: A0A1B0ZGR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1630135:DAD186 RS00515
gene id: 1630135:DAD186_RS00515
uniprot id: A0A1B0ZFC9
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1630135:DAD186 RS02695
gene id: 1630135:DAD186_RS02695
uniprot id: A0A1B0ZGQ3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1630135:DAD186 RS09845
gene id: 1630135:DAD186_RS09845
uniprot id: A0A1B0ZKL2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1630135:DAD186 RS07790
gene id: 1630135:DAD186_RS07790
uniprot id: A0A5P2QZ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1630135:DAD186 RS06600
gene id: 1630135:DAD186_RS06600
uniprot id: A0A1B0ZIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1630135:DAD186 RS05065
gene id: 1630135:DAD186_RS05065
uniprot id: A0A1B0ZI38
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1630135:DAD186 RS03285
gene id: 1630135:DAD186_RS03285
uniprot id: A0A1B0ZGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1630135:DAD186 RS06280
gene id: 1630135:DAD186_RS06280
uniprot id: A0A1B0ZIS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS02435
gene id: 1630135:DAD186_RS02435
uniprot id: A0A1B0ZGK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1630135:DAD186 RS09955
gene id: 1630135:DAD186_RS09955
uniprot id: A0A1B0ZKN1
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1630135:DAD186 RS08145
gene id: 1630135:DAD186_RS08145
uniprot id: A0A1B0ZK29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1630135:DAD186 RS02635
gene id: 1630135:DAD186_RS02635
uniprot id: A0A1B0ZGP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1630135:DAD186 RS08670
gene id: 1630135:DAD186_RS08670
uniprot id: A0A1B0ZK37
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05205
gene id: 1630135:DAD186_RS05205
uniprot id: A0A1B0ZI46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS07745
gene id: 1630135:DAD186_RS07745
uniprot id: A0A5P2QZ97
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1630135:DAD186 RS01220
gene id: 1630135:DAD186_RS01220
uniprot id: A0A1B0ZFT1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1630135:DAD186 RS01025
gene id: 1630135:DAD186_RS01025
uniprot id: A0A1B0ZFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS06660
gene id: 1630135:DAD186_RS06660
uniprot id: A0A1B0ZJ29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1630135:DAD186 RS02930
gene id: 1630135:DAD186_RS02930
uniprot id: A0A1B0ZGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1630135:DAD186 RS04830
gene id: 1630135:DAD186_RS04830
uniprot id: A0A1B0ZHR8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1630135:DAD186 RS04590
gene id: 1630135:DAD186_RS04590
uniprot id: A0A5P2R1W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1630135:DAD186 RS10025
gene id: 1630135:DAD186_RS10025
uniprot id: A0A1B0ZKV6
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1630135:DAD186 RS05545
gene id: 1630135:DAD186_RS05545
uniprot id: A0A1B0ZI88
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS00520
gene id: 1630135:DAD186_RS00520
uniprot id: A0A1B0ZFF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS08030
gene id: 1630135:DAD186_RS08030
uniprot id: A0A1B0ZJQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1630135:DAD186 RS05400
gene id: 1630135:DAD186_RS05400
uniprot id: A0A1B0ZI62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

1630135:DAD186 RS07910
gene id: 1630135:DAD186_RS07910
uniprot id: A0A1B0ZJQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1630135:DAD186 RS01855
gene id: 1630135:DAD186_RS01855
uniprot id: A0A1B0ZG60
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

1630135:DAD186 RS09225
gene id: 1630135:DAD186_RS09225
uniprot id: A0A1B0ZKE5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05155
gene id: 1630135:DAD186_RS05155
uniprot id: A0A1B0ZI68
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1630135:DAD186 RS08780
gene id: 1630135:DAD186_RS08780
uniprot id: A0A1B0ZJZ9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1630135:DAD186 RS00800
gene id: 1630135:DAD186_RS00800
uniprot id: A0A1B0ZFK7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1630135:DAD186 RS08350
gene id: 1630135:DAD186_RS08350
uniprot id: A0A1B0ZJQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1630135:DAD186 RS08680
gene id: 1630135:DAD186_RS08680
uniprot id: A0A1B0ZJZ1
names: Similarity
messages: Belongs to the HsdR family.

1630135:DAD186 RS06640
gene id: 1630135:DAD186_RS06640
uniprot id: A0A5P2R538
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1630135:DAD186 RS05730
gene id: 1630135:DAD186_RS05730
uniprot id: A0A1B0ZIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1630135:DAD186 RS09960
gene id: 1630135:DAD186_RS09960
uniprot id: A0A1B0ZKN2
names: Similarity
messages: Belongs to the asparaginase 1 family.

1630135:DAD186 RS08485
gene id: 1630135:DAD186_RS08485
uniprot id: A0A1B0ZJU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1630135:DAD186 RS00525
gene id: 1630135:DAD186_RS00525
uniprot id: A0A1B0ZFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS09495
gene id: 1630135:DAD186_RS09495
uniprot id: A0A1B0ZKD9
names: Similarity
messages: Belongs to the peptidase C40 family.

1630135:DAD186 RS08110
gene id: 1630135:DAD186_RS08110
uniprot id: A0A1B0ZJV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1630135:DAD186 RS10270
gene id: 1630135:DAD186_RS10270
uniprot id: A0A1B0ZL35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS03315
gene id: 1630135:DAD186_RS03315
uniprot id: A0A1B0ZH36
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04585
gene id: 1630135:DAD186_RS04585
uniprot id: A0A1B0ZHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1630135:DAD186 RS08270
gene id: 1630135:DAD186_RS08270
uniprot id: A0A1B0ZK13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1630135:DAD186 RS00115
gene id: 1630135:DAD186_RS00115
uniprot id: A0A1B0ZF68
names: Similarity
messages: Belongs to the FGGY kinase family.

1630135:DAD186 RS07155
gene id: 1630135:DAD186_RS07155
uniprot id: A0A1B0ZJ60
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1630135:DAD186 RS05195
gene id: 1630135:DAD186_RS05195
uniprot id: A0A1B0ZI26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1630135:DAD186 RS00375
gene id: 1630135:DAD186_RS00375
uniprot id: A0A1B0ZFA4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1630135:DAD186 RS05015
gene id: 1630135:DAD186_RS05015
uniprot id: A0A1B0ZI28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1630135:DAD186 RS10215
gene id: 1630135:DAD186_RS10215
uniprot id: A0A1B0ZKV7
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01525
gene id: 1630135:DAD186_RS01525
uniprot id: A0A1B0ZFZ7
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1630135:DAD186 RS00980
gene id: 1630135:DAD186_RS00980
uniprot id: A0A1B0ZFM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS10160
gene id: 1630135:DAD186_RS10160
uniprot id: A0A1B0ZL05
names: Similarity
messages: Belongs to the TPP enzyme family.

1630135:DAD186 RS01770
gene id: 1630135:DAD186_RS01770
uniprot id: A0A1B0ZG47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1630135:DAD186 RS05265
gene id: 1630135:DAD186_RS05265
uniprot id: A0A1B0ZI19
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.

1630135:DAD186 RS04755
gene id: 1630135:DAD186_RS04755
uniprot id: A0A1B0ZHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

1630135:DAD186 RS08050
gene id: 1630135:DAD186_RS08050
uniprot id: A0A1B0ZJT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1630135:DAD186 RS08965
gene id: 1630135:DAD186_RS08965
uniprot id: A0A1B0ZK30
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1630135:DAD186 RS08765
gene id: 1630135:DAD186_RS08765
uniprot id: A0A1B0ZK12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS01195
gene id: 1630135:DAD186_RS01195
uniprot id: A0A1B0ZFU0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1630135:DAD186 RS06135
gene id: 1630135:DAD186_RS06135
uniprot id: A0A1B0ZIL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1630135:DAD186 RS03440
gene id: 1630135:DAD186_RS03440
uniprot id: A0A1B0ZH52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1630135:DAD186 RS07610
gene id: 1630135:DAD186_RS07610
uniprot id: A0A1B0ZJB3
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1630135:DAD186 RS02395
gene id: 1630135:DAD186_RS02395
uniprot id: A0A1B0ZGG5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1630135:DAD186 RS06420
gene id: 1630135:DAD186_RS06420
uniprot id: A0A1B0ZIN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1630135:DAD186 RS04210
gene id: 1630135:DAD186_RS04210
uniprot id: A0A1B0ZHG2
names: Similarity
messages: Belongs to the MQO family.

1630135:DAD186 RS03350
gene id: 1630135:DAD186_RS03350
uniprot id: A0A1B0ZH51
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1630135:DAD186 RS03485
gene id: 1630135:DAD186_RS03485
uniprot id: A0A1B0ZGY7
names: Similarity
messages: Belongs to the peptidase M24B family.

1630135:DAD186 RS02090
gene id: 1630135:DAD186_RS02090
uniprot id: A0A1B0ZG95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS02515
gene id: 1630135:DAD186_RS02515
uniprot id: A0A1B0ZGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1630135:DAD186 RS04690
gene id: 1630135:DAD186_RS04690
uniprot id: A0A1B0ZHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1630135:DAD186 RS06680
gene id: 1630135:DAD186_RS06680
uniprot id: A0A1B0ZIW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1630135:DAD186 RS05555
gene id: 1630135:DAD186_RS05555
uniprot id: A0A1B0ZIB2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS06070
gene id: 1630135:DAD186_RS06070
uniprot id: A0A1B0ZIN7
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02555
gene id: 1630135:DAD186_RS02555
uniprot id: A0A1B0ZGM2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1630135:DAD186 RS08925
gene id: 1630135:DAD186_RS08925
uniprot id: A0A1B0ZKF8
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02740
gene id: 1630135:DAD186_RS02740
uniprot id: A0A1B0ZGS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1630135:DAD186 RS09200
gene id: 1630135:DAD186_RS09200
uniprot id: A0A1B0ZKH9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1630135:DAD186 RS07725
gene id: 1630135:DAD186_RS07725
uniprot id: A0A1B0ZJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1630135:DAD186 RS09460
gene id: 1630135:DAD186_RS09460
uniprot id: A0A1B0ZKR9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1630135:DAD186 RS02860
gene id: 1630135:DAD186_RS02860
uniprot id: A0A1B0ZGU3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1630135:DAD186 RS01635
gene id: 1630135:DAD186_RS01635
uniprot id: A0A1B0ZG26
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1630135:DAD186 RS02415
gene id: 1630135:DAD186_RS02415
uniprot id: A0A1B0ZGM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1630135:DAD186 RS00590
gene id: 1630135:DAD186_RS00590
uniprot id: A0A5P2R020
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1630135:DAD186 RS05745
gene id: 1630135:DAD186_RS05745
uniprot id: A0A1B0ZIC8
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1630135:DAD186 RS08790
gene id: 1630135:DAD186_RS08790
uniprot id: A0A1B0ZK71
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1630135:DAD186 RS08550
gene id: 1630135:DAD186_RS08550
uniprot id: A0A1B0ZJU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1630135:DAD186 RS06410
gene id: 1630135:DAD186_RS06410
uniprot id: A0A1B0ZIW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS04150
gene id: 1630135:DAD186_RS04150
uniprot id: A0A1B0ZHN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1630135:DAD186 RS02750
gene id: 1630135:DAD186_RS02750
uniprot id: A0A1B0ZGL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1630135:DAD186 RS02420
gene id: 1630135:DAD186_RS02420
uniprot id: A0A1B0ZGI2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1630135:DAD186 RS03290
gene id: 1630135:DAD186_RS03290
uniprot id: A0A1B0ZH22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1630135:DAD186 RS06735
gene id: 1630135:DAD186_RS06735
uniprot id: A0A1B0ZJ12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1630135:DAD186 RS05125
gene id: 1630135:DAD186_RS05125
uniprot id: A0A5P2R5X3
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02645
gene id: 1630135:DAD186_RS02645
uniprot id: A0A5P2R482
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1630135:DAD186 RS00565
gene id: 1630135:DAD186_RS00565
uniprot id: A0A1B0ZFF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1630135:DAD186 RS02670
gene id: 1630135:DAD186_RS02670
uniprot id: A0A1B0ZGS1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1630135:DAD186 RS02325
gene id: 1630135:DAD186_RS02325
uniprot id: A0A1B0ZGE3
names: Similarity
messages: Belongs to the XFP family.

1630135:DAD186 RS07780
gene id: 1630135:DAD186_RS07780
uniprot id: A0A1B0ZJV0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1630135:DAD186 RS01040
gene id: 1630135:DAD186_RS01040
uniprot id: A0A1B0ZFR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS00635
gene id: 1630135:DAD186_RS00635
uniprot id: A0A1B0ZFF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1630135:DAD186 RS04915
gene id: 1630135:DAD186_RS04915
uniprot id: A0A1B0ZI17
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1630135:DAD186 RS03930
gene id: 1630135:DAD186_RS03930
uniprot id: A0A1B0ZH79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1630135:DAD186 RS03650
gene id: 1630135:DAD186_RS03650
uniprot id: A0A1B0ZHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1630135:DAD186 RS00860
gene id: 1630135:DAD186_RS00860
uniprot id: A0A1B0ZFL9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1630135:DAD186 RS08475
gene id: 1630135:DAD186_RS08475
uniprot id: A0A5P2R2L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1630135:DAD186 RS07300
gene id: 1630135:DAD186_RS07300
uniprot id: A0A1B0ZJE0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS09055
gene id: 1630135:DAD186_RS09055
uniprot id: A0A1B0ZKE9
names: Similarity
messages: Belongs to the CsoR family.

1630135:DAD186 RS08205
gene id: 1630135:DAD186_RS08205
uniprot id: A0A1B0ZJM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1630135:DAD186 RS05185
gene id: 1630135:DAD186_RS05185
uniprot id: A0A1B0ZI18
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1630135:DAD186 RS05535
gene id: 1630135:DAD186_RS05535
uniprot id: A0A1B0ZI89
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

1630135:DAD186 RS04190
gene id: 1630135:DAD186_RS04190
uniprot id: A0A1B0ZHM1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1630135:DAD186 RS01905
gene id: 1630135:DAD186_RS01905
uniprot id: A0A1B0ZG69
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1630135:DAD186 RS02685
gene id: 1630135:DAD186_RS02685
uniprot id: A0A1B0ZGQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1630135:DAD186 RS10405
gene id: 1630135:DAD186_RS10405
uniprot id: A0A1B0ZL71
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1630135:DAD186 RS02800
gene id: 1630135:DAD186_RS02800
uniprot id: A0A1B0ZGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1630135:DAD186 RS00005
gene id: 1630135:DAD186_RS00005
uniprot id: A0A1B0ZF46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1630135:DAD186 RS02385
gene id: 1630135:DAD186_RS02385
uniprot id: A0A1B0ZGK4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

1630135:DAD186 RS01820
gene id: 1630135:DAD186_RS01820
uniprot id: A0A1B0ZG65
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS01535
gene id: 1630135:DAD186_RS01535
uniprot id: A0A1B0ZFZ6
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1630135:DAD186 RS01595
gene id: 1630135:DAD186_RS01595
uniprot id: A0A1B0ZG24
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1630135:DAD186 RS08730
gene id: 1630135:DAD186_RS08730
uniprot id: A0A1B0ZKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1630135:DAD186 RS06405
gene id: 1630135:DAD186_RS06405
uniprot id: A0A1B0ZIQ7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1630135:DAD186 RS04890
gene id: 1630135:DAD186_RS04890
uniprot id: A0A1B0ZI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS04085
gene id: 1630135:DAD186_RS04085
uniprot id: A0A1B0ZHI3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1630135:DAD186 RS08185
gene id: 1630135:DAD186_RS08185
uniprot id: A0A1B0ZJW7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1630135:DAD186 RS02220
gene id: 1630135:DAD186_RS02220
uniprot id: A0A1B0ZGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1630135:DAD186 RS04265
gene id: 1630135:DAD186_RS04265
uniprot id: A0A1B0ZHL6
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1630135:DAD186 RS09790
gene id: 1630135:DAD186_RS09790
uniprot id: A0A1B0ZKZ6
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

1630135:DAD186 RS04795
gene id: 1630135:DAD186_RS04795
uniprot id: A0A1B0ZHZ7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1630135:DAD186 RS08875
gene id: 1630135:DAD186_RS08875
uniprot id: A0A1B0ZK76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS04375
gene id: 1630135:DAD186_RS04375
uniprot id: A0A1B0ZHP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1630135:DAD186 RS01805
gene id: 1630135:DAD186_RS01805
uniprot id: A0A1B0ZG52
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1630135:DAD186 RS04600
gene id: 1630135:DAD186_RS04600
uniprot id: A0A1B0ZHL2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1630135:DAD186 RS00010
gene id: 1630135:DAD186_RS00010
uniprot id: A0A1B0ZF44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1630135:DAD186 RS07735
gene id: 1630135:DAD186_RS07735
uniprot id: A0A1B0ZJU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1630135:DAD186 RS02040
gene id: 1630135:DAD186_RS02040
uniprot id: A0A1B0ZG98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1630135:DAD186 RS05600
gene id: 1630135:DAD186_RS05600
uniprot id: A0A1B0ZIF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1630135:DAD186 RS01660
gene id: 1630135:DAD186_RS01660
uniprot id: A0A1B0ZG00
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1630135:DAD186 RS03620
gene id: 1630135:DAD186_RS03620
uniprot id: A0A1B0ZH49
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1630135:DAD186 RS02810
gene id: 1630135:DAD186_RS02810
uniprot id: A0A1B0ZGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1630135:DAD186 RS06650
gene id: 1630135:DAD186_RS06650
uniprot id: A0A1B0ZJ04
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS07170
gene id: 1630135:DAD186_RS07170
uniprot id: A0A1B0ZJ24
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1630135:DAD186 RS09465
gene id: 1630135:DAD186_RS09465
uniprot id: A0A1B0ZKJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS00120
gene id: 1630135:DAD186_RS00120
uniprot id: A0A1B0ZF61
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1630135:DAD186 RS09010
gene id: 1630135:DAD186_RS09010
uniprot id: A0A1B0ZK40
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.
messages: Belongs to the FMO family.

1630135:DAD186 RS05595
gene id: 1630135:DAD186_RS05595
uniprot id: A0A1B0ZI96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1630135:DAD186 RS01725
gene id: 1630135:DAD186_RS01725
uniprot id: A0A1B0ZG36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS03675
gene id: 1630135:DAD186_RS03675
uniprot id: A0A1B0ZH26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1630135:DAD186 RS05565
gene id: 1630135:DAD186_RS05565
uniprot id: A0A1B0ZIC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1630135:DAD186 RS08630
gene id: 1630135:DAD186_RS08630
uniprot id: A0A1B0ZJX8
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

1630135:DAD186 RS06250
gene id: 1630135:DAD186_RS06250
uniprot id: A0A1B0ZIU2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1630135:DAD186 RS02575
gene id: 1630135:DAD186_RS02575
uniprot id: A0A1B0ZGR2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1630135:DAD186 RS05720
gene id: 1630135:DAD186_RS05720
uniprot id: A0A1B0ZIF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1630135:DAD186 RS02535
gene id: 1630135:DAD186_RS02535
uniprot id: A0A1B0ZGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1630135:DAD186 RS05685
gene id: 1630135:DAD186_RS05685
uniprot id: A0A1B0ZIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1630135:DAD186 RS08160
gene id: 1630135:DAD186_RS08160
uniprot id: A0A1B0ZJL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS02425
gene id: 1630135:DAD186_RS02425
uniprot id: A0A1B0ZGH3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1630135:DAD186 RS09930
gene id: 1630135:DAD186_RS09930
uniprot id: A0A1B0ZKT3
names: Similarity
messages: Belongs to the peptidase S8 family.

1630135:DAD186 RS06550
gene id: 1630135:DAD186_RS06550
uniprot id: A0A1B0ZIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1630135:DAD186 RS04420
gene id: 1630135:DAD186_RS04420
uniprot id: A0A1B0ZHS5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1630135:DAD186 RS02990
gene id: 1630135:DAD186_RS02990
uniprot id: A0A1B0ZF77
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08320
gene id: 1630135:DAD186_RS08320
uniprot id: A0A1B0ZK23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1630135:DAD186 RS06610
gene id: 1630135:DAD186_RS06610
uniprot id: A0A1B0ZIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1630135:DAD186 RS00300
gene id: 1630135:DAD186_RS00300
uniprot id: A0A1B0ZF96
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1630135:DAD186 RS02360
gene id: 1630135:DAD186_RS02360
uniprot id: A0A1B0ZGL4
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1630135:DAD186 RS07845
gene id: 1630135:DAD186_RS07845
uniprot id: A0A1B0ZJL2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1630135:DAD186 RS08380
gene id: 1630135:DAD186_RS08380
uniprot id: A0A1B0ZK05
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01720
gene id: 1630135:DAD186_RS01720
uniprot id: A0A1B0ZG41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS02450
gene id: 1630135:DAD186_RS02450
uniprot id: A0A1B0ZGH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1630135:DAD186 RS03380
gene id: 1630135:DAD186_RS03380
uniprot id: A0A1B0ZGZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1630135:DAD186 RS05765
gene id: 1630135:DAD186_RS05765
uniprot id: A0A1B0ZIH2
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

1630135:DAD186 RS09050
gene id: 1630135:DAD186_RS09050
uniprot id: A0A1B0ZKK6
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1630135:DAD186 RS07460
gene id: 1630135:DAD186_RS07460
uniprot id: A0A1B0ZJH1
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1630135:DAD186 RS06665
gene id: 1630135:DAD186_RS06665
uniprot id: A0A1B0ZIZ5
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.

1630135:DAD186 RS05290
gene id: 1630135:DAD186_RS05290
uniprot id: A0A1B0ZI44
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1630135:DAD186 RS05010
gene id: 1630135:DAD186_RS05010
uniprot id: A0A1B0ZHX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1630135:DAD186 RS06595
gene id: 1630135:DAD186_RS06595
uniprot id: A0A1B0ZIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1630135:DAD186 RS03585
gene id: 1630135:DAD186_RS03585
uniprot id: A0A1B0ZHA1
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1630135:DAD186 RS06805
gene id: 1630135:DAD186_RS06805
uniprot id: A0A1B0ZIW6
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

1630135:DAD186 RS03765
gene id: 1630135:DAD186_RS03765
uniprot id: A0A1B0ZHF6
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1630135:DAD186 RS10495
gene id: 1630135:DAD186_RS10495
uniprot id: A0A1B0ZL73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1630135:DAD186 RS04055
gene id: 1630135:DAD186_RS04055
uniprot id: A0A1B0ZHI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS04855
gene id: 1630135:DAD186_RS04855
uniprot id: A0A1B0ZI04
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS10325
gene id: 1630135:DAD186_RS10325
uniprot id: A0A1B0ZKW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1630135:DAD186 RS04615
gene id: 1630135:DAD186_RS04615
uniprot id: A0A1B0ZHT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1630135:DAD186 RS00185
gene id: 1630135:DAD186_RS00185
uniprot id: A0A1B0ZF77
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS02650
gene id: 1630135:DAD186_RS02650
uniprot id: A0A1B0ZGK2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1630135:DAD186 RS04360
gene id: 1630135:DAD186_RS04360
uniprot id: A0A1B0ZHH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1630135:DAD186 RS08610
gene id: 1630135:DAD186_RS08610
uniprot id: A0A1B0ZK89
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1630135:DAD186 RS02275
gene id: 1630135:DAD186_RS02275
uniprot id: A0A1B0ZGD5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS08860
gene id: 1630135:DAD186_RS08860
uniprot id: A0A1B0ZK79
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1630135:DAD186 RS04730
gene id: 1630135:DAD186_RS04730
uniprot id: A0A1B0ZHZ5
names: Similarity
messages: Belongs to the thymidine kinase family.

1630135:DAD186 RS00575
gene id: 1630135:DAD186_RS00575
uniprot id: A0A1B0ZFE0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05620
gene id: 1630135:DAD186_RS05620
uniprot id: A0A1B0ZIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1630135:DAD186 RS04135
gene id: 1630135:DAD186_RS04135
uniprot id: A0A1B0ZHE1
names: Similarity
messages: Belongs to the peptidase S13 family.

1630135:DAD186 RS07500
gene id: 1630135:DAD186_RS07500
uniprot id: A0A1B0ZJQ2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1630135:DAD186 RS05690
gene id: 1630135:DAD186_RS05690
uniprot id: A0A1B0ZI94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1630135:DAD186 RS01365
gene id: 1630135:DAD186_RS01365
uniprot id: A0A1B0ZFV4
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1630135:DAD186 RS05530
gene id: 1630135:DAD186_RS05530
uniprot id: A0A1B0ZIK4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

1630135:DAD186 RS09430
gene id: 1630135:DAD186_RS09430
uniprot id: A0A1B0ZKT0
names: Similarity
messages: Belongs to the peptidase M18 family.

1630135:DAD186 RS04870
gene id: 1630135:DAD186_RS04870
uniprot id: A0A1B0ZI08
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1630135:DAD186 RS02280
gene id: 1630135:DAD186_RS02280
uniprot id: A0A1B0ZGI8
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS06185
gene id: 1630135:DAD186_RS06185
uniprot id: A0A1B0ZIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1630135:DAD186 RS07305
gene id: 1630135:DAD186_RS07305
uniprot id: A0A5P2R4N8
names: Similarity
messages: Belongs to the GSP E family.

1630135:DAD186 RS03855
gene id: 1630135:DAD186_RS03855
uniprot id: A0A1B0ZHF2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1630135:DAD186 RS02795
gene id: 1630135:DAD186_RS02795
uniprot id: A0A1B0ZGS3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1630135:DAD186 RS09455
gene id: 1630135:DAD186_RS09455
uniprot id: A0A1B0ZKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1630135:DAD186 RS09220
gene id: 1630135:DAD186_RS09220
uniprot id: A0A1B0ZKL9
names: Similarity
messages: Belongs to the GSP E family.

1630135:DAD186 RS07295
gene id: 1630135:DAD186_RS07295
uniprot id: A0A1B0ZJ80
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS07565
gene id: 1630135:DAD186_RS07565
uniprot id: A0A1B0ZJ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1630135:DAD186 RS04140
gene id: 1630135:DAD186_RS04140
uniprot id: A0A1B0ZHL3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1630135:DAD186 RS03430
gene id: 1630135:DAD186_RS03430
uniprot id: A0A1B0ZH06
names: Similarity
messages: Belongs to the citrate synthase family.

1630135:DAD186 RS06315
gene id: 1630135:DAD186_RS06315
uniprot id: A0A1B0ZIR4
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1630135:DAD186 RS02640
gene id: 1630135:DAD186_RS02640
uniprot id: A0A1B0ZGQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1630135:DAD186 RS02660
gene id: 1630135:DAD186_RS02660
uniprot id: A0A1B0ZGQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1630135:DAD186 RS07980
gene id: 1630135:DAD186_RS07980
uniprot id: A0A1B0ZJP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1630135:DAD186 RS09660
gene id: 1630135:DAD186_RS09660
uniprot id: A0A1B0ZKP4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1630135:DAD186 RS06810
gene id: 1630135:DAD186_RS06810
uniprot id: A0A1B0ZJ58
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1630135:DAD186 RS08760
gene id: 1630135:DAD186_RS08760
uniprot id: A0A1B0ZK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS06020
gene id: 1630135:DAD186_RS06020
uniprot id: A0A1B0ZIL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1630135:DAD186 RS04165
gene id: 1630135:DAD186_RS04165
uniprot id: A0A1B0ZHC9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: In the N-terminal section; belongs to the DHNA family.

1630135:DAD186 RS01400
gene id: 1630135:DAD186_RS01400
uniprot id: A0A1B0ZFY8
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1630135:DAD186 RS04155
gene id: 1630135:DAD186_RS04155
uniprot id: A0A1B0ZHM8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1630135:DAD186 RS09175
gene id: 1630135:DAD186_RS09175
uniprot id: A0A1B0ZKK9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1630135:DAD186 RS06500
gene id: 1630135:DAD186_RS06500
uniprot id: A0A1B0ZIQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS01640
gene id: 1630135:DAD186_RS01640
uniprot id: A0A1B0ZG22
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05630
gene id: 1630135:DAD186_RS05630
uniprot id: A0A1B0ZIE4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS03130
gene id: 1630135:DAD186_RS03130
uniprot id: A0A1B0ZGU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1630135:DAD186 RS09160
gene id: 1630135:DAD186_RS09160
uniprot id: A0A1B0ZK66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1630135:DAD186 RS06435
gene id: 1630135:DAD186_RS06435
uniprot id: A0A1B0ZJ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS05160
gene id: 1630135:DAD186_RS05160
uniprot id: A0A1B0ZI36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1630135:DAD186 RS10420
gene id: 1630135:DAD186_RS10420
uniprot id: A0A1B0ZL00
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1630135:DAD186 RS09470
gene id: 1630135:DAD186_RS09470
uniprot id: A0A1B0ZKL1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1630135:DAD186 RS05090
gene id: 1630135:DAD186_RS05090
uniprot id: A0A1B0ZHZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1630135:DAD186 RS03760
gene id: 1630135:DAD186_RS03760
uniprot id: A0A1B0ZHC1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1630135:DAD186 RS01825
gene id: 1630135:DAD186_RS01825
uniprot id: A0A1B0ZG81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS05140
gene id: 1630135:DAD186_RS05140
uniprot id: A0A1B0ZI01
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1630135:DAD186 RS02630
gene id: 1630135:DAD186_RS02630
uniprot id: A0A1B0ZGJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1630135:DAD186 RS08230
gene id: 1630135:DAD186_RS08230
uniprot id: A0A1B0ZJV3
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS06190
gene id: 1630135:DAD186_RS06190
uniprot id: A0A1B0ZIJ2
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS09610
gene id: 1630135:DAD186_RS09610
uniprot id: A0A1B0ZKU1
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS09195
gene id: 1630135:DAD186_RS09195
uniprot id: A0A1B0ZKN5
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS04645
gene id: 1630135:DAD186_RS04645
uniprot id: A0A1B0ZHP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS05375
gene id: 1630135:DAD186_RS05375
uniprot id: A0A1B0ZI87
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS07185
gene id: 1630135:DAD186_RS07185
uniprot id: A0A1B0ZJD8
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1630135:DAD186 RS06770
gene id: 1630135:DAD186_RS06770
uniprot id: A0A1B0ZJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

1630135:DAD186 RS02520
gene id: 1630135:DAD186_RS02520
uniprot id: A0A1B0ZGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1630135:DAD186 RS06340
gene id: 1630135:DAD186_RS06340
uniprot id: A0A1B0ZIT6
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

1630135:DAD186 RS04910
gene id: 1630135:DAD186_RS04910
uniprot id: A0A1B0ZI42
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1630135:DAD186 RS10355
gene id: 1630135:DAD186_RS10355
uniprot id: A0A1B0ZL36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1630135:DAD186 RS09265
gene id: 1630135:DAD186_RS09265
uniprot id: A0A1B0ZKL6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1630135:DAD186 RS06210
gene id: 1630135:DAD186_RS06210
uniprot id: A0A1B0ZIK1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1630135:DAD186 RS03780
gene id: 1630135:DAD186_RS03780
uniprot id: A0A1B0ZH48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1630135:DAD186 RS07960
gene id: 1630135:DAD186_RS07960
uniprot id: A0A1B0ZJZ0
names: Subcellular Location Annotation
messages: Cytoplasm

1630135:DAD186 RS01100
gene id: 1630135:DAD186_RS01100
uniprot id: A0A1B0ZFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1630135:DAD186 RS06320
gene id: 1630135:DAD186_RS06320
uniprot id: A0A1B0ZIL8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1630135:DAD186 RS08265
gene id: 1630135:DAD186_RS08265
uniprot id: A0A1B0ZJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1630135:DAD186 RS04650
gene id: 1630135:DAD186_RS04650
uniprot id: A0A1B0ZHM9
names: Similarity
messages: Belongs to the thioredoxin family.

1630135:DAD186 RS04565
gene id: 1630135:DAD186_RS04565
uniprot id: A0A1B0ZHU5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS10365
gene id: 1630135:DAD186_RS10365
uniprot id: A0A1B0ZL75
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1630135:DAD186 RS02455
gene id: 1630135:DAD186_RS02455
uniprot id: A0A1B0ZGM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1630135:DAD186 RS08815
gene id: 1630135:DAD186_RS08815
uniprot id: A0A1B0ZK22
names: Similarity
messages: Belongs to the catalase family.

1630135:DAD186 RS04675
gene id: 1630135:DAD186_RS04675
uniprot id: A0A1B0ZHV7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1630135:DAD186 RS09775
gene id: 1630135:DAD186_RS09775
uniprot id: A0A1B0ZKQ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

1630135:DAD186 RS01870
gene id: 1630135:DAD186_RS01870
uniprot id: A0A1B0ZG72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1630135:DAD186 RS06750
gene id: 1630135:DAD186_RS06750
uniprot id: A0A1B0ZJ48
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Non-allosteric.

1630135:DAD186 RS08450
gene id: 1630135:DAD186_RS08450
uniprot id: A0A1B0ZJS5
names: Similarity
messages: Belongs to the GcvT family.

1630135:DAD186 RS03850
gene id: 1630135:DAD186_RS03850
uniprot id: A0A1B0ZH86
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1630135:DAD186 RS08025
gene id: 1630135:DAD186_RS08025
uniprot id: A0A1B0ZJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1630135:DAD186 RS07375
gene id: 1630135:DAD186_RS07375
uniprot id: A0A1B0ZJ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1630135:DAD186 RS06195
gene id: 1630135:DAD186_RS06195
uniprot id: A0A1B0ZIM0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS05940
gene id: 1630135:DAD186_RS05940
uniprot id: A0A1B0ZIE2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1630135:DAD186 RS01650
gene id: 1630135:DAD186_RS01650
uniprot id: A0A1B0ZG35
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1630135:DAD186 RS08130
gene id: 1630135:DAD186_RS08130
uniprot id: A0A1B0ZJY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1630135:DAD186 RS03500
gene id: 1630135:DAD186_RS03500
uniprot id: A0A1B0ZH62
names: Similarity
messages: Belongs to the DEAD box helicase family.

1630135:DAD186 RS08200
gene id: 1630135:DAD186_RS08200
uniprot id: A0A1B0ZJX2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS07730
gene id: 1630135:DAD186_RS07730
uniprot id: A0A1B0ZJE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1630135:DAD186 RS01900
gene id: 1630135:DAD186_RS01900
uniprot id: A0A1B0ZG70
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1630135:DAD186 RS05550
gene id: 1630135:DAD186_RS05550
uniprot id: A0A1B0ZIE6
names: Function
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

1630135:DAD186 RS05450
gene id: 1630135:DAD186_RS05450
uniprot id: A0A1B0ZI72
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS01505
gene id: 1630135:DAD186_RS01505
uniprot id: A0A1B0ZG07
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1630135:DAD186 RS05835
gene id: 1630135:DAD186_RS05835
uniprot id: A0A1B0ZIF2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1630135:DAD186 RS00315
gene id: 1630135:DAD186_RS00315
uniprot id: A0A1B0ZFA0
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS03150
gene id: 1630135:DAD186_RS03150
uniprot id: A0A1B0ZGZ9
names: Subcellular Location Annotation
messages: Membrane

1630135:DAD186 RS09285
gene id: 1630135:DAD186_RS09285
uniprot id: A0A5P2QYH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.