161899:CSING RS01090
gene id: 161899:CSING_RS01090
uniprot id: A0A0B6F182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

161899:CSING RS08375
gene id: 161899:CSING_RS08375
uniprot id: A0A0B6F208
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

161899:CSING RS02315
gene id: 161899:CSING_RS02315
uniprot id: A0A0B6EYN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

161899:CSING RS07445
gene id: 161899:CSING_RS07445
uniprot id: A0A0B6F1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS01775
gene id: 161899:CSING_RS01775
uniprot id: A0A0B6F1L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

161899:CSING RS05665
gene id: 161899:CSING_RS05665
uniprot id: A0A0B6F0I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

161899:CSING RS05205
gene id: 161899:CSING_RS05205
uniprot id: A0A0B6F0C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

161899:CSING RS05900
gene id: 161899:CSING_RS05900
uniprot id: A0A0B6EQH0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

161899:CSING RS08725
gene id: 161899:CSING_RS08725
uniprot id: A0A0B6F261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

161899:CSING RS03055
gene id: 161899:CSING_RS03055
uniprot id: A0A0B6F2C5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

161899:CSING RS00320
gene id: 161899:CSING_RS00320
uniprot id: A0A0B6EXH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein.

161899:CSING RS10285
gene id: 161899:CSING_RS10285
uniprot id: A0A0B6F5F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS12010
gene id: 161899:CSING_RS12010
uniprot id: A0A0B6F686
names: Similarity
messages: Belongs to the AccD/PCCB family.

161899:CSING RS04455
gene id: 161899:CSING_RS04455
uniprot id: A0A0B6EZT9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

161899:CSING RS06755
gene id: 161899:CSING_RS06755
uniprot id: A0A0B6F377
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

161899:CSING RS05610
gene id: 161899:CSING_RS05610
uniprot id: A0A0B6EV43
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

161899:CSING RS01275
gene id: 161899:CSING_RS01275
uniprot id: A0A0B6F042
names: Subcellular Location Annotation
messages: Cytoplasm

161899:CSING RS02280
gene id: 161899:CSING_RS02280
uniprot id: A0A0B6ENF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

161899:CSING RS11280
gene id: 161899:CSING_RS11280
uniprot id: A0A0B6ETH1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS08665
gene id: 161899:CSING_RS08665
uniprot id: A0A0B6ERY7
names: Similarity
messages: Belongs to the HSP15 family.

161899:CSING RS07605
gene id: 161899:CSING_RS07605
uniprot id: A0A0B6F521
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

161899:CSING RS04890
gene id: 161899:CSING_RS04890
uniprot id: A0A0B6EPZ1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

161899:CSING RS05750
gene id: 161899:CSING_RS05750
uniprot id: A0A0B6EQE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

161899:CSING RS02310
gene id: 161899:CSING_RS02310
uniprot id: A0A0B6ETB6
names: Similarity
messages: Belongs to the CFA/CMAS family.

161899:CSING RS11885
gene id: 161899:CSING_RS11885
uniprot id: A0A0B6F7C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

161899:CSING RS07235
gene id: 161899:CSING_RS07235
uniprot id: A0A0B6EVZ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

161899:CSING RS02890
gene id: 161899:CSING_RS02890
uniprot id: A0A0B6ETN1
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

161899:CSING RS12920
gene id: 161899:CSING_RS12920
uniprot id: A0A0B6EUJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

161899:CSING RS04220
gene id: 161899:CSING_RS04220
uniprot id: A0A0B6EUA8
names: Similarity
messages: Belongs to the peptidase M20A family.

161899:CSING RS02055
gene id: 161899:CSING_RS02055
uniprot id: A0A0B6EN92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

161899:CSING RS00120
gene id: 161899:CSING_RS00120
uniprot id: A0A0B6ES60
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

161899:CSING RS05625
gene id: 161899:CSING_RS05625
uniprot id: A0A0B6F3U1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

161899:CSING RS05040
gene id: 161899:CSING_RS05040
uniprot id: A0A0B6EQ42
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

161899:CSING RS06905
gene id: 161899:CSING_RS06905
uniprot id: A0A0B6F3B4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

161899:CSING RS05270
gene id: 161899:CSING_RS05270
uniprot id: A0A0B6EQ74
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11785
gene id: 161899:CSING_RS11785
uniprot id: A0A0B6EYN3
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

161899:CSING RS05470
gene id: 161899:CSING_RS05470
uniprot id: A0A0B6F3R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

161899:CSING RS10620
gene id: 161899:CSING_RS10620
uniprot id: A0A0B6EY08
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

161899:CSING RS12445
gene id: 161899:CSING_RS12445
uniprot id: A0A0B6F7N3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS12865
gene id: 161899:CSING_RS12865
uniprot id: A0A0B6F7Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

161899:CSING RS02215
gene id: 161899:CSING_RS02215
uniprot id: A0A0B6EYL0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03980
gene id: 161899:CSING_RS03980
uniprot id: A0A0B6EPB7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

161899:CSING RS04925
gene id: 161899:CSING_RS04925
uniprot id: A0A0B6F047
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02150
gene id: 161899:CSING_RS02150
uniprot id: A0A0B6F1U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS04095
gene id: 161899:CSING_RS04095
uniprot id: A0A0B6EU84
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

161899:CSING RS02660
gene id: 161899:CSING_RS02660
uniprot id: A0A0B6F107
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS08720
gene id: 161899:CSING_RS08720
uniprot id: A0A0B6EWV3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

161899:CSING RS08130
gene id: 161899:CSING_RS08130
uniprot id: A0A0B6F1X4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10795
gene id: 161899:CSING_RS10795
uniprot id: A0A0B6ET89
names: Similarity
messages: Belongs to the CsoR family.

161899:CSING RS05780
gene id: 161899:CSING_RS05780
uniprot id: A0A0B6EV70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

161899:CSING RS08145
gene id: 161899:CSING_RS08145
uniprot id: A0A0B6ERQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

161899:CSING RS08835
gene id: 161899:CSING_RS08835
uniprot id: A0A0B6ES19
names: Similarity
messages: Belongs to the YggT family.

161899:CSING RS01670
gene id: 161899:CSING_RS01670
uniprot id: A0A0B6EY74
names: Similarity
messages: Belongs to the YoeB family.

161899:CSING RS10145
gene id: 161899:CSING_RS10145
uniprot id: A0A0B6ET09
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

161899:CSING RS07220
gene id: 161899:CSING_RS07220
uniprot id: A0A0B6F3I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

161899:CSING RS00735
gene id: 161899:CSING_RS00735
uniprot id: A0A0B6EXN7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10705
gene id: 161899:CSING_RS10705
uniprot id: A0A0B6EY20
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS04980
gene id: 161899:CSING_RS04980
uniprot id: A0A0B6F298
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01185
gene id: 161899:CSING_RS01185
uniprot id: A0A0B6F1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS01795
gene id: 161899:CSING_RS01795
uniprot id: A0A0B6F0E5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS10765
gene id: 161899:CSING_RS10765
uniprot id: A0A0B6F3F8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

161899:CSING RS09695
gene id: 161899:CSING_RS09695
uniprot id: A0A0B6EXG0
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

161899:CSING RS11675
gene id: 161899:CSING_RS11675
uniprot id: A0A0B6F784
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

161899:CSING RS02135
gene id: 161899:CSING_RS02135
uniprot id: A0A0B6ET72
names: Similarity
messages: Belongs to the asp23 family.

161899:CSING RS05810
gene id: 161899:CSING_RS05810
uniprot id: A0A0B6F0K9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02100
gene id: 161899:CSING_RS02100
uniprot id: A0A0B6F1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

161899:CSING RS08340
gene id: 161899:CSING_RS08340
uniprot id: A0A0B6ERT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

161899:CSING RS07795
gene id: 161899:CSING_RS07795
uniprot id: A0A0B6ERK9
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

161899:CSING RS11560
gene id: 161899:CSING_RS11560
uniprot id: A0A0B6EYJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

161899:CSING RS11330
gene id: 161899:CSING_RS11330
uniprot id: A0A0B6ETH8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

161899:CSING RS02270
gene id: 161899:CSING_RS02270
uniprot id: A0A0B6F0Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

161899:CSING RS09000
gene id: 161899:CSING_RS09000
uniprot id: A0A0B6F4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

161899:CSING RS02705
gene id: 161899:CSING_RS02705
uniprot id: A0A0B6EYX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

161899:CSING RS01815
gene id: 161899:CSING_RS01815
uniprot id: A0A0B6F0F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

161899:CSING RS06270
gene id: 161899:CSING_RS06270
uniprot id: A0A0B6F0S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

161899:CSING RS12460
gene id: 161899:CSING_RS12460
uniprot id: A0A0B6F4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

161899:CSING RS11605
gene id: 161899:CSING_RS11605
uniprot id: A0A0B6ETN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

161899:CSING RS06365
gene id: 161899:CSING_RS06365
uniprot id: A0A0B6EVH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

161899:CSING RS09815
gene id: 161899:CSING_RS09815
uniprot id: A0A0B6F2W8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

161899:CSING RS09085
gene id: 161899:CSING_RS09085
uniprot id: A0A0B6ES64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

161899:CSING RS10630
gene id: 161899:CSING_RS10630
uniprot id: A0A0B6F5K9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

161899:CSING RS00225
gene id: 161899:CSING_RS00225
uniprot id: A0A0B6EXG3
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01615
gene id: 161899:CSING_RS01615
uniprot id: A0A0B6ESX4
names: Similarity
messages: Belongs to the LOR family.

161899:CSING RS02095
gene id: 161899:CSING_RS02095
uniprot id: A0A0B6F0L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

161899:CSING RS10560
gene id: 161899:CSING_RS10560
uniprot id: A0A0B6F6N7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08100
gene id: 161899:CSING_RS08100
uniprot id: A0A0B6EWI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

161899:CSING RS07800
gene id: 161899:CSING_RS07800
uniprot id: A0A0B6EWE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS12725
gene id: 161899:CSING_RS12725
uniprot id: A0A0B6F7W0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS10135
gene id: 161899:CSING_RS10135
uniprot id: A0A0B6F5D6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

161899:CSING RS09220
gene id: 161899:CSING_RS09220
uniprot id: A0A0B6F4N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

161899:CSING RS08140
gene id: 161899:CSING_RS08140
uniprot id: A0A0B6F599
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

161899:CSING RS10815
gene id: 161899:CSING_RS10815
uniprot id: A0A0B6F5N2
names: Similarity
messages: Belongs to the PhoU family.

161899:CSING RS09735
gene id: 161899:CSING_RS09735
uniprot id: A0A0B6F650
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

161899:CSING RS05560
gene id: 161899:CSING_RS05560
uniprot id: A0A0B6EV35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

161899:CSING RS05655
gene id: 161899:CSING_RS05655
uniprot id: A0A0B6EQC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

161899:CSING RS05975
gene id: 161899:CSING_RS05975
uniprot id: A0A0B6EQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

161899:CSING RS01805
gene id: 161899:CSING_RS01805
uniprot id: A0A0B6ET07
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS08020
gene id: 161899:CSING_RS08020
uniprot id: A0A0B6ERN7
names: Similarity
messages: Belongs to the PspA/IM30 family.

161899:CSING RS11320
gene id: 161899:CSING_RS11320
uniprot id: A0A0B6F5W2
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

161899:CSING RS01620
gene id: 161899:CSING_RS01620
uniprot id: A0A0B6EY59
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

161899:CSING RS01675
gene id: 161899:CSING_RS01675
uniprot id: A0A0B6F0B7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

161899:CSING RS01745
gene id: 161899:CSING_RS01745
uniprot id: A0A0B6F0D2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08705
gene id: 161899:CSING_RS08705
uniprot id: A0A0B6F4C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

161899:CSING RS08155
gene id: 161899:CSING_RS08155
uniprot id: A0A0B6F1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

161899:CSING RS12270
gene id: 161899:CSING_RS12270
uniprot id: A0A0B6F4A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

161899:CSING RS09115
gene id: 161899:CSING_RS09115
uniprot id: A0A0B6F2D9
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

161899:CSING RS02435
gene id: 161899:CSING_RS02435
uniprot id: A0A0B6F0S8
names: Similarity
messages: Belongs to the WXG100 family.

161899:CSING RS12540
gene id: 161899:CSING_RS12540
uniprot id: A0A0B6F6I5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01245
gene id: 161899:CSING_RS01245
uniprot id: A0A0B6EXX4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS02350
gene id: 161899:CSING_RS02350
uniprot id: A0A0B6F200
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

161899:CSING RS01665
gene id: 161899:CSING_RS01665
uniprot id: A0A0B6ESY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

161899:CSING RS11525
gene id: 161899:CSING_RS11525
uniprot id: A0A0B6F751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

161899:CSING RS07060
gene id: 161899:CSING_RS07060
uniprot id: A0A0B6F3F1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

161899:CSING RS04495
gene id: 161899:CSING_RS04495
uniprot id: A0A0B6EUG1
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

161899:CSING RS09045
gene id: 161899:CSING_RS09045
uniprot id: A0A0B6F2C2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

161899:CSING RS10495
gene id: 161899:CSING_RS10495
uniprot id: A0A0B6F3C3
names: Similarity
messages: Belongs to the peptidase S33 family.

161899:CSING RS12915
gene id: 161899:CSING_RS12915
uniprot id: A0A0B6F7Z1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

161899:CSING RS12290
gene id: 161899:CSING_RS12290
uniprot id: A0A0B6EYY8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06910
gene id: 161899:CSING_RS06910
uniprot id: A0A0B6F4J0
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

161899:CSING RS04280
gene id: 161899:CSING_RS04280
uniprot id: A0A0B6EZP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS05160
gene id: 161899:CSING_RS05160
uniprot id: A0A0B6F2F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

161899:CSING RS09470
gene id: 161899:CSING_RS09470
uniprot id: A0A0B6F2N6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

161899:CSING RS02775
gene id: 161899:CSING_RS02775
uniprot id: A0A0B6F127
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

161899:CSING RS02875
gene id: 161899:CSING_RS02875
uniprot id: A0A0B6F143
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

161899:CSING RS06255
gene id: 161899:CSING_RS06255
uniprot id: A0A0B6F456
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

161899:CSING RS02320
gene id: 161899:CSING_RS02320
uniprot id: A0A0B6F0R0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

161899:CSING RS11995
gene id: 161899:CSING_RS11995
uniprot id: A0A0B6ETY5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10310
gene id: 161899:CSING_RS10310
uniprot id: A0A0B6F5G1
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

161899:CSING RS07365
gene id: 161899:CSING_RS07365
uniprot id: A0A0B6EW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS11055
gene id: 161899:CSING_RS11055
uniprot id: A0A0B6ETD2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08160
gene id: 161899:CSING_RS08160
uniprot id: A0A0B6F438
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

161899:CSING RS07210
gene id: 161899:CSING_RS07210
uniprot id: A0A0B6EVZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

161899:CSING RS05035
gene id: 161899:CSING_RS05035
uniprot id: A0A0B6F3K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

161899:CSING RS06685
gene id: 161899:CSING_RS06685
uniprot id: A0A0B6F4D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

161899:CSING RS07985
gene id: 161899:CSING_RS07985
uniprot id: A0A0B6F410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS07255
gene id: 161899:CSING_RS07255
uniprot id: A0A0B6ER84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

161899:CSING RS08350
gene id: 161899:CSING_RS08350
uniprot id: A0A0B6F206
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

161899:CSING RS07040
gene id: 161899:CSING_RS07040
uniprot id: A0A0B6F4L6
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08360
gene id: 161899:CSING_RS08360
uniprot id: A0A0B6F5D0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS05925
gene id: 161899:CSING_RS05925
uniprot id: A0A0B6EQH5
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

161899:CSING RS07975
gene id: 161899:CSING_RS07975
uniprot id: A0A0B6EWG6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

161899:CSING RS11640
gene id: 161899:CSING_RS11640
uniprot id: A0A0B6F3V8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS09385
gene id: 161899:CSING_RS09385
uniprot id: A0A0B6F5Y3
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

161899:CSING RS12735
gene id: 161899:CSING_RS12735
uniprot id: A0A0B6EUH5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS11775
gene id: 161899:CSING_RS11775
uniprot id: A0A0B6F7A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

161899:CSING RS00630
gene id: 161899:CSING_RS00630
uniprot id: A0A0B6EMF5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.

161899:CSING RS00745
gene id: 161899:CSING_RS00745
uniprot id: A0A0B6F119
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08295
gene id: 161899:CSING_RS08295
uniprot id: A0A0B6EWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

161899:CSING RS08405
gene id: 161899:CSING_RS08405
uniprot id: A0A0B6F476
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

161899:CSING RS01240
gene id: 161899:CSING_RS01240
uniprot id: A0A0B6ESQ8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12905
gene id: 161899:CSING_RS12905
uniprot id: A0A0B6F4P9
names: Similarity
messages: Belongs to the ParB family.

161899:CSING RS03570
gene id: 161899:CSING_RS03570
uniprot id: A0A0B6F2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS00740
gene id: 161899:CSING_RS00740
uniprot id: A0A0B6EZV8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07535
gene id: 161899:CSING_RS07535
uniprot id: A0A0B6ERF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

161899:CSING RS12140
gene id: 161899:CSING_RS12140
uniprot id: A0A0B6EYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

161899:CSING RS06245
gene id: 161899:CSING_RS06245
uniprot id: A0A0B6F0R8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

161899:CSING RS10645
gene id: 161899:CSING_RS10645
uniprot id: A0A0B6EY13
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS10450
gene id: 161899:CSING_RS10450
uniprot id: A0A0B6F3B5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08320
gene id: 161899:CSING_RS08320
uniprot id: A0A0B6EWL9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

161899:CSING RS06465
gene id: 161899:CSING_RS06465
uniprot id: A0A0B6EVJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

161899:CSING RS03480
gene id: 161899:CSING_RS03480
uniprot id: A0A0B6ETX1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

161899:CSING RS06460
gene id: 161899:CSING_RS06460
uniprot id: A0A0B6EQR1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

161899:CSING RS09355
gene id: 161899:CSING_RS09355
uniprot id: A0A0B6F4R3
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

161899:CSING RS06335
gene id: 161899:CSING_RS06335
uniprot id: A0A0B6EQP1
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

161899:CSING RS08245
gene id: 161899:CSING_RS08245
uniprot id: A0A0B6EWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

161899:CSING RS07620
gene id: 161899:CSING_RS07620
uniprot id: A0A0B6F1Q6
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

161899:CSING RS07125
gene id: 161899:CSING_RS07125
uniprot id: A0A0B6EVX8
names: Similarity
messages: Belongs to the TlyA family.

161899:CSING RS04110
gene id: 161899:CSING_RS04110
uniprot id: A0A0B6F2X3
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

161899:CSING RS02515
gene id: 161899:CSING_RS02515
uniprot id: A0A0B6F245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

161899:CSING RS09095
gene id: 161899:CSING_RS09095
uniprot id: A0A0B6F2D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

161899:CSING RS11480
gene id: 161899:CSING_RS11480
uniprot id: A0A0B6ETK8
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

161899:CSING RS00010
gene id: 161899:CSING_RS00010
uniprot id: A0A0B6EZG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

161899:CSING RS02810
gene id: 161899:CSING_RS02810
uniprot id: A0A0B6ENT4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05920
gene id: 161899:CSING_RS05920
uniprot id: A0A0B6F3Z3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS08610
gene id: 161899:CSING_RS08610
uniprot id: A0A0B6F5H9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

161899:CSING RS05240
gene id: 161899:CSING_RS05240
uniprot id: A0A0B6F3N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

161899:CSING RS00700
gene id: 161899:CSING_RS00700
uniprot id: A0A0B6EMG6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

161899:CSING RS07475
gene id: 161899:CSING_RS07475
uniprot id: A0A0B6F3P3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS10960
gene id: 161899:CSING_RS10960
uniprot id: A0A0B6F3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

161899:CSING RS09080
gene id: 161899:CSING_RS09080
uniprot id: A0A0B6F5R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

161899:CSING RS00815
gene id: 161899:CSING_RS00815
uniprot id: A0A0B6EXP9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06860
gene id: 161899:CSING_RS06860
uniprot id: A0A0B6F4H8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS04885
gene id: 161899:CSING_RS04885
uniprot id: A0A0B6F3F3
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07755
gene id: 161899:CSING_RS07755
uniprot id: A0A0B6F1S4
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

161899:CSING RS05185
gene id: 161899:CSING_RS05185
uniprot id: A0A0B6F2G3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

161899:CSING RS06995
gene id: 161899:CSING_RS06995
uniprot id: A0A0B6ER19
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS12600
gene id: 161899:CSING_RS12600
uniprot id: A0A0B6EUD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

161899:CSING RS01645
gene id: 161899:CSING_RS01645
uniprot id: A0A0B6EY66
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

161899:CSING RS05070
gene id: 161899:CSING_RS05070
uniprot id: A0A0B6EUX6
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

161899:CSING RS12405
gene id: 161899:CSING_RS12405
uniprot id: A0A0B6EZ15
names: Similarity
messages: Belongs to the PspA/IM30 family.

161899:CSING RS11975
gene id: 161899:CSING_RS11975
uniprot id: A0A0B6EYR4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

161899:CSING RS03860
gene id: 161899:CSING_RS03860
uniprot id: A0A0B6EU40
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS02565
gene id: 161899:CSING_RS02565
uniprot id: A0A0B6F262
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

161899:CSING RS02275
gene id: 161899:CSING_RS02275
uniprot id: A0A0B6F1Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

161899:CSING RS12420
gene id: 161899:CSING_RS12420
uniprot id: A0A0B6F7M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

161899:CSING RS04700
gene id: 161899:CSING_RS04700
uniprot id: A0A0B6EZZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

161899:CSING RS08890
gene id: 161899:CSING_RS08890
uniprot id: A0A0B6EWZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

161899:CSING RS12135
gene id: 161899:CSING_RS12135
uniprot id: A0A0B6EU19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

161899:CSING RS01915
gene id: 161899:CSING_RS01915
uniprot id: A0A0B6EN58
names: Similarity
messages: Belongs to the transposase 7 family.

161899:CSING RS08075
gene id: 161899:CSING_RS08075
uniprot id: A0A0B6EWH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

161899:CSING RS12750
gene id: 161899:CSING_RS12750
uniprot id: A0A0B6F6Q6
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

161899:CSING RS08500
gene id: 161899:CSING_RS08500
uniprot id: A0A0B6F229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

161899:CSING RS12520
gene id: 161899:CSING_RS12520
uniprot id: A0A0B6F7P9
names: Similarity
messages: Belongs to the FPG family.

161899:CSING RS01400
gene id: 161899:CSING_RS01400
uniprot id: A0A0B6F1E4
names: Similarity
messages: Belongs to the peptidase M1 family.

161899:CSING RS04210
gene id: 161899:CSING_RS04210
uniprot id: A0A0B6F2Z4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

161899:CSING RS10150
gene id: 161899:CSING_RS10150
uniprot id: A0A0B6EXU9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

161899:CSING RS07850
gene id: 161899:CSING_RS07850
uniprot id: A0A0B6EWF2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

161899:CSING RS12775
gene id: 161899:CSING_RS12775
uniprot id: A0A0B6F6R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

161899:CSING RS02360
gene id: 161899:CSING_RS02360
uniprot id: A0A0B6ETC9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

161899:CSING RS10950
gene id: 161899:CSING_RS10950
uniprot id: A0A0B6ETB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

161899:CSING RS00810
gene id: 161899:CSING_RS00810
uniprot id: A0A0B6ESG7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS02955
gene id: 161899:CSING_RS02955
uniprot id: A0A0B6F2B0
names: Similarity
messages: Belongs to the AccD/PCCB family.

161899:CSING RS11570
gene id: 161899:CSING_RS11570
uniprot id: A0A0B6F608
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07615
gene id: 161899:CSING_RS07615
uniprot id: A0A0B6EWC2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07570
gene id: 161899:CSING_RS07570
uniprot id: A0A0B6F1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

161899:CSING RS07120
gene id: 161899:CSING_RS07120
uniprot id: A0A0B6ER48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS12265
gene id: 161899:CSING_RS12265
uniprot id: A0A0B6EYY0
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

161899:CSING RS09100
gene id: 161899:CSING_RS09100
uniprot id: A0A0B6F4K2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

161899:CSING RS11625
gene id: 161899:CSING_RS11625
uniprot id: A0A0B6F772
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

161899:CSING RS08300
gene id: 161899:CSING_RS08300
uniprot id: A0A0B6F1Z9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

161899:CSING RS04440
gene id: 161899:CSING_RS04440
uniprot id: A0A0B6F341
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

161899:CSING RS02355
gene id: 161899:CSING_RS02355
uniprot id: A0A0B6ENH5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

161899:CSING RS08215
gene id: 161899:CSING_RS08215
uniprot id: A0A0B6ERR2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

161899:CSING RS06040
gene id: 161899:CSING_RS06040
uniprot id: A0A0B6F2V0
names: Similarity
messages: Belongs to the isochorismate synthase family.

161899:CSING RS03700
gene id: 161899:CSING_RS03700
uniprot id: A0A0B6EP71
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

161899:CSING RS09765
gene id: 161899:CSING_RS09765
uniprot id: A0A0B6ESP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

161899:CSING RS02990
gene id: 161899:CSING_RS02990
uniprot id: A0A0B6ETP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS12185
gene id: 161899:CSING_RS12185
uniprot id: A0A0B6EU32
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

161899:CSING RS09295
gene id: 161899:CSING_RS09295
uniprot id: A0A0B6ESB6
names: Similarity
messages: Belongs to the glutamine synthetase family.

161899:CSING RS03370
gene id: 161899:CSING_RS03370
uniprot id: A0A0B6F2I5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS12250
gene id: 161899:CSING_RS12250
uniprot id: A0A0B6F6C7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

161899:CSING RS04485
gene id: 161899:CSING_RS04485
uniprot id: A0A0B6F1Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

161899:CSING RS08850
gene id: 161899:CSING_RS08850
uniprot id: A0A0B6F4F2
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

161899:CSING RS07400
gene id: 161899:CSING_RS07400
uniprot id: A0A0B6F3M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

161899:CSING RS06765
gene id: 161899:CSING_RS06765
uniprot id: A0A0B6EQX2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

161899:CSING RS02145
gene id: 161899:CSING_RS02145
uniprot id: A0A0B6F0M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

161899:CSING RS07190
gene id: 161899:CSING_RS07190
uniprot id: A0A0B6F1C8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS00090
gene id: 161899:CSING_RS00090
uniprot id: A0A0B6EM87
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS04430
gene id: 161899:CSING_RS04430
uniprot id: A0A0B6EZT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

161899:CSING RS02085
gene id: 161899:CSING_RS02085
uniprot id: A0A0B6ET62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

161899:CSING RS00025
gene id: 161899:CSING_RS00025
uniprot id: A0A0B6ES51
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

161899:CSING RS11090
gene id: 161899:CSING_RS11090
uniprot id: A0A0B6EY95
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

161899:CSING RS04505
gene id: 161899:CSING_RS04505
uniprot id: A0A0B6F1Z0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

161899:CSING RS04905
gene id: 161899:CSING_RS04905
uniprot id: A0A0B6F280
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

161899:CSING RS06020
gene id: 161899:CSING_RS06020
uniprot id: A0A0B6F413
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS08230
gene id: 161899:CSING_RS08230
uniprot id: A0A0B6F449
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

161899:CSING RS03625
gene id: 161899:CSING_RS03625
uniprot id: A0A0B6EP57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

161899:CSING RS11700
gene id: 161899:CSING_RS11700
uniprot id: A0A0B6F789
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

161899:CSING RS01640
gene id: 161899:CSING_RS01640
uniprot id: A0A0B6ESX7
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

161899:CSING RS04545
gene id: 161899:CSING_RS04545
uniprot id: A0A0B6EZW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

161899:CSING RS06580
gene id: 161899:CSING_RS06580
uniprot id: A0A0B6F4B8
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

161899:CSING RS12180
gene id: 161899:CSING_RS12180
uniprot id: A0A0B6F7H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

161899:CSING RS00455
gene id: 161899:CSING_RS00455
uniprot id: A0A0B6EMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

161899:CSING RS02805
gene id: 161899:CSING_RS02805
uniprot id: A0A0B6F292
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

161899:CSING RS09970
gene id: 161899:CSING_RS09970
uniprot id: A0A0B6F6A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

161899:CSING RS12675
gene id: 161899:CSING_RS12675
uniprot id: A0A0B6F7V2
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

161899:CSING RS00315
gene id: 161899:CSING_RS00315
uniprot id: A0A0B6ES86
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07435
gene id: 161899:CSING_RS07435
uniprot id: A0A0B6ERC6
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

161899:CSING RS04710
gene id: 161899:CSING_RS04710
uniprot id: A0A0B6F3B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

161899:CSING RS11160
gene id: 161899:CSING_RS11160
uniprot id: A0A0B6EYB0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

161899:CSING RS08870
gene id: 161899:CSING_RS08870
uniprot id: A0A0B6F285
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06435
gene id: 161899:CSING_RS06435
uniprot id: A0A0B6EQQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

161899:CSING RS01635
gene id: 161899:CSING_RS01635
uniprot id: A0A0B6EMY6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

161899:CSING RS05680
gene id: 161899:CSING_RS05680
uniprot id: A0A0B6EQD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

161899:CSING RS08570
gene id: 161899:CSING_RS08570
uniprot id: A0A0B6EWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

161899:CSING RS06095
gene id: 161899:CSING_RS06095
uniprot id: A0A0B6F0P9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05280
gene id: 161899:CSING_RS05280
uniprot id: A0A0B6F0D3
names: Similarity
messages: Belongs to the LOG family.

161899:CSING RS04740
gene id: 161899:CSING_RS04740
uniprot id: A0A0B6EPV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

161899:CSING RS10625
gene id: 161899:CSING_RS10625
uniprot id: A0A0B6F3E1
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

161899:CSING RS02590
gene id: 161899:CSING_RS02590
uniprot id: A0A0B6F266
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

161899:CSING RS11510
gene id: 161899:CSING_RS11510
uniprot id: A0A0B6EYI0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09025
gene id: 161899:CSING_RS09025
uniprot id: A0A0B6F4I9
names: Similarity
messages: Belongs to the asparagine synthetase family.

161899:CSING RS01770
gene id: 161899:CSING_RS01770
uniprot id: A0A0B6F0D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

161899:CSING RS06835
gene id: 161899:CSING_RS06835
uniprot id: A0A0B6F4H2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06065
gene id: 161899:CSING_RS06065
uniprot id: A0A0B6F2V5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

161899:CSING RS01415
gene id: 161899:CSING_RS01415
uniprot id: A0A0B6EY11
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

161899:CSING RS01420
gene id: 161899:CSING_RS01420
uniprot id: A0A0B6F070
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

161899:CSING RS02950
gene id: 161899:CSING_RS02950
uniprot id: A0A0B6F155
names: Similarity
messages: Belongs to the AccD/PCCB family.

161899:CSING RS10565
gene id: 161899:CSING_RS10565
uniprot id: A0A0B6ET60
names: Similarity
messages: Belongs to the peptidase S58 family.

161899:CSING RS06400
gene id: 161899:CSING_RS06400
uniprot id: A0A0B6F307
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

161899:CSING RS08855
gene id: 161899:CSING_RS08855
uniprot id: A0A0B6F5M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

161899:CSING RS08580
gene id: 161899:CSING_RS08580
uniprot id: A0A0B6F4A5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06340
gene id: 161899:CSING_RS06340
uniprot id: A0A0B6EVH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

161899:CSING RS12630
gene id: 161899:CSING_RS12630
uniprot id: A0A0B6EUD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS05685
gene id: 161899:CSING_RS05685
uniprot id: A0A0B6EV56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

161899:CSING RS05630
gene id: 161899:CSING_RS05630
uniprot id: A0A0B6EQC3
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

161899:CSING RS03635
gene id: 161899:CSING_RS03635
uniprot id: A0A0B6EZB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

161899:CSING RS06405
gene id: 161899:CSING_RS06405
uniprot id: A0A0B6F487
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

161899:CSING RS01280
gene id: 161899:CSING_RS01280
uniprot id: A0A0B6F1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

161899:CSING RS08880
gene id: 161899:CSING_RS08880
uniprot id: A0A0B6F5N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

161899:CSING RS05955
gene id: 161899:CSING_RS05955
uniprot id: A0A0B6EV97
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00990
gene id: 161899:CSING_RS00990
uniprot id: A0A0B6ESK2
names: Similarity
messages: Belongs to the catalase family.

161899:CSING RS09665
gene id: 161899:CSING_RS09665
uniprot id: A0A0B6ESM1
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

161899:CSING RS07095
gene id: 161899:CSING_RS07095
uniprot id: A0A0B6ER44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

161899:CSING RS11505
gene id: 161899:CSING_RS11505
uniprot id: A0A0B6ETL3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

161899:CSING RS00490
gene id: 161899:CSING_RS00490
uniprot id: A0A0B6EXK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

161899:CSING RS01180
gene id: 161899:CSING_RS01180
uniprot id: A0A0B6F026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS10675
gene id: 161899:CSING_RS10675
uniprot id: A0A0B6ET74
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00150
gene id: 161899:CSING_RS00150
uniprot id: A0A0B6EXF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

161899:CSING RS04745
gene id: 161899:CSING_RS04745
uniprot id: A0A0B6EUM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07550
gene id: 161899:CSING_RS07550
uniprot id: A0A0B6F3R8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

161899:CSING RS05225
gene id: 161899:CSING_RS05225
uniprot id: A0A0B6EUZ7
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

161899:CSING RS02765
gene id: 161899:CSING_RS02765
uniprot id: A0A0B6ETL7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

161899:CSING RS08600
gene id: 161899:CSING_RS08600
uniprot id: A0A0B6F242
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

161899:CSING RS05440
gene id: 161899:CSING_RS05440
uniprot id: A0A0B6F2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

161899:CSING RS04690
gene id: 161899:CSING_RS04690
uniprot id: A0A0B6EPT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06920
gene id: 161899:CSING_RS06920
uniprot id: A0A0B6EVT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

161899:CSING RS02170
gene id: 161899:CSING_RS02170
uniprot id: A0A0B6F0M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

161899:CSING RS06115
gene id: 161899:CSING_RS06115
uniprot id: A0A0B6EVC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

161899:CSING RS10725
gene id: 161899:CSING_RS10725
uniprot id: A0A0B6ET81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

161899:CSING RS01660
gene id: 161899:CSING_RS01660
uniprot id: A0A0B6EMZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS13045
gene id: 161899:CSING_RS13045
uniprot id: A0A0B6EUF9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

161899:CSING RS03095
gene id: 161899:CSING_RS03095
uniprot id: A0A0B6EZ31
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

161899:CSING RS01120
gene id: 161899:CSING_RS01120
uniprot id: A0A0B6EMP2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03420
gene id: 161899:CSING_RS03420
uniprot id: A0A0B6F2J4
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

161899:CSING RS12760
gene id: 161899:CSING_RS12760
uniprot id: A0A0B6EUH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS00105
gene id: 161899:CSING_RS00105
uniprot id: A0A0B6EZK5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

161899:CSING RS08115
gene id: 161899:CSING_RS08115
uniprot id: A0A0B6F595
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

161899:CSING RS05010
gene id: 161899:CSING_RS05010
uniprot id: A0A0B6F3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

161899:CSING RS05140
gene id: 161899:CSING_RS05140
uniprot id: A0A0B6EQ59
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

161899:CSING RS01055
gene id: 161899:CSING_RS01055
uniprot id: A0A0B6EMM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

161899:CSING RS07935
gene id: 161899:CSING_RS07935
uniprot id: A0A0B6F403
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

161899:CSING RS08495
gene id: 161899:CSING_RS08495
uniprot id: A0A0B6EWQ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

161899:CSING RS11460
gene id: 161899:CSING_RS11460
uniprot id: A0A0B6EYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

161899:CSING RS10235
gene id: 161899:CSING_RS10235
uniprot id: A0A0B6F5F0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

161899:CSING RS10375
gene id: 161899:CSING_RS10375
uniprot id: A0A0B6ET38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS01340
gene id: 161899:CSING_RS01340
uniprot id: A0A0B6EXZ2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

161899:CSING RS07555
gene id: 161899:CSING_RS07555
uniprot id: A0A0B6F504
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

161899:CSING RS12125
gene id: 161899:CSING_RS12125
uniprot id: A0A0B6F6A7
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

161899:CSING RS11990
gene id: 161899:CSING_RS11990
uniprot id: A0A0B6F7E5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06250
gene id: 161899:CSING_RS06250
uniprot id: A0A0B6F2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

161899:CSING RS08070
gene id: 161899:CSING_RS08070
uniprot id: A0A0B6ERP2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02815
gene id: 161899:CSING_RS02815
uniprot id: A0A0B6ETM2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

161899:CSING RS04780
gene id: 161899:CSING_RS04780
uniprot id: A0A0B6F251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

161899:CSING RS10055
gene id: 161899:CSING_RS10055
uniprot id: A0A0B6EXT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

161899:CSING RS00575
gene id: 161899:CSING_RS00575
uniprot id: A0A0B6F0Y8
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

161899:CSING RS07910
gene id: 161899:CSING_RS07910
uniprot id: A0A0B6F400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

161899:CSING RS05950
gene id: 161899:CSING_RS05950
uniprot id: A0A0B6EQI0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

161899:CSING RS04445
gene id: 161899:CSING_RS04445
uniprot id: A0A0B6EPM0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

161899:CSING RS04590
gene id: 161899:CSING_RS04590
uniprot id: A0A0B6EUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

161899:CSING RS00450
gene id: 161899:CSING_RS00450
uniprot id: A0A0B6F0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

161899:CSING RS12285
gene id: 161899:CSING_RS12285
uniprot id: A0A0B6EU61
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

161899:CSING RS02540
gene id: 161899:CSING_RS02540
uniprot id: A0A0B6F258
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

161899:CSING RS06220
gene id: 161899:CSING_RS06220
uniprot id: A0A0B6F2X6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

161899:CSING RS03485
gene id: 161899:CSING_RS03485
uniprot id: A0A0B6EZ90
names: Similarity
messages: Belongs to the TPP enzyme family.

161899:CSING RS12130
gene id: 161899:CSING_RS12130
uniprot id: A0A0B6F7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

161899:CSING RS06325
gene id: 161899:CSING_RS06325
uniprot id: A0A0B6F2Z2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

161899:CSING RS02175
gene id: 161899:CSING_RS02175
uniprot id: A0A0B6F1V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

161899:CSING RS04010
gene id: 161899:CSING_RS04010
uniprot id: A0A0B6EZI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

161899:CSING RS10875
gene id: 161899:CSING_RS10875
uniprot id: A0A0B6ETA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

161899:CSING RS08525
gene id: 161899:CSING_RS08525
uniprot id: A0A0B6F232
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

161899:CSING RS09200
gene id: 161899:CSING_RS09200
uniprot id: A0A0B6F5T6
names: Similarity
messages: Belongs to the glutamine synthetase family.

161899:CSING RS08760
gene id: 161899:CSING_RS08760
uniprot id: A0A0B6F5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS02020
gene id: 161899:CSING_RS02020
uniprot id: A0A0B6F1R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

161899:CSING RS01955
gene id: 161899:CSING_RS01955
uniprot id: A0A0B6EN66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

161899:CSING RS02645
gene id: 161899:CSING_RS02645
uniprot id: A0A0B6ENQ9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

161899:CSING RS10500
gene id: 161899:CSING_RS10500
uniprot id: A0A0B6F5I8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

161899:CSING RS07450
gene id: 161899:CSING_RS07450
uniprot id: A0A0B6F3N6
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07520
gene id: 161899:CSING_RS07520
uniprot id: A0A0B6F1K6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

161899:CSING RS05455
gene id: 161899:CSING_RS05455
uniprot id: A0A0B6EV23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

161899:CSING RS10100
gene id: 161899:CSING_RS10100
uniprot id: A0A0B6EXU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS08550
gene id: 161899:CSING_RS08550
uniprot id: A0A0B6F236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

161899:CSING RS11710
gene id: 161899:CSING_RS11710
uniprot id: A0A0B6EYL9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

161899:CSING RS04140
gene id: 161899:CSING_RS04140
uniprot id: A0A0B6EPF1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

161899:CSING RS02620
gene id: 161899:CSING_RS02620
uniprot id: A0A0B6ENQ5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07705
gene id: 161899:CSING_RS07705
uniprot id: A0A0B6F1R5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

161899:CSING RS02090
gene id: 161899:CSING_RS02090
uniprot id: A0A0B6EYI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

161899:CSING RS10830
gene id: 161899:CSING_RS10830
uniprot id: A0A0B6EY42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

161899:CSING RS03575
gene id: 161899:CSING_RS03575
uniprot id: A0A0B6EP49
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

161899:CSING RS02430
gene id: 161899:CSING_RS02430
uniprot id: A0A0B6EYQ3
names: Similarity
messages: Belongs to the WXG100 family.

161899:CSING RS05550
gene id: 161899:CSING_RS05550
uniprot id: A0A0B6F3T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

161899:CSING RS11450
gene id: 161899:CSING_RS11450
uniprot id: A0A0B6F739
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05605
gene id: 161899:CSING_RS05605
uniprot id: A0A0B6EQB9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

161899:CSING RS10370
gene id: 161899:CSING_RS10370
uniprot id: A0A0B6F6L0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

161899:CSING RS08480
gene id: 161899:CSING_RS08480
uniprot id: A0A0B6F489
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

161899:CSING RS01875
gene id: 161899:CSING_RS01875
uniprot id: A0A0B6EN45
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05650
gene id: 161899:CSING_RS05650
uniprot id: A0A0B6F3U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

161899:CSING RS12880
gene id: 161899:CSING_RS12880
uniprot id: A0A0B6F4P8
names: Similarity
messages: Belongs to the thioredoxin family.

161899:CSING RS06380
gene id: 161899:CSING_RS06380
uniprot id: A0A0B6F482
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS12155
gene id: 161899:CSING_RS12155
uniprot id: A0A0B6F7H2
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

161899:CSING RS09860
gene id: 161899:CSING_RS09860
uniprot id: A0A0B6EXL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS12355
gene id: 161899:CSING_RS12355
uniprot id: A0A0B6F7L6
names: Similarity
messages: Belongs to the universal stress protein A family.

161899:CSING RS00715
gene id: 161899:CSING_RS00715
uniprot id: A0A0B6EZV4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00110
gene id: 161899:CSING_RS00110
uniprot id: A0A0B6F0S7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

161899:CSING RS09015
gene id: 161899:CSING_RS09015
uniprot id: A0A0B6EX18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

161899:CSING RS12160
gene id: 161899:CSING_RS12160
uniprot id: A0A0B6EU26
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

161899:CSING RS11825
gene id: 161899:CSING_RS11825
uniprot id: A0A0B6F7B9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12115
gene id: 161899:CSING_RS12115
uniprot id: A0A0B6EYT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

161899:CSING RS07710
gene id: 161899:CSING_RS07710
uniprot id: A0A0B6F3W7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02210
gene id: 161899:CSING_RS02210
uniprot id: A0A0B6ET90
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

161899:CSING RS08110
gene id: 161899:CSING_RS08110
uniprot id: A0A0B6F429
names: Similarity
messages: Belongs to the ribF family.

161899:CSING RS02670
gene id: 161899:CSING_RS02670
uniprot id: A0A0B6ENR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

161899:CSING RS00625
gene id: 161899:CSING_RS00625
uniprot id: A0A0B6F0Z5
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

161899:CSING RS05380
gene id: 161899:CSING_RS05380
uniprot id: A0A0B6EQ88
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

161899:CSING RS02830
gene id: 161899:CSING_RS02830
uniprot id: A0A0B6F294
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09810
gene id: 161899:CSING_RS09810
uniprot id: A0A0B6EXJ8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

161899:CSING RS09075
gene id: 161899:CSING_RS09075
uniprot id: A0A0B6F4J7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08780
gene id: 161899:CSING_RS08780
uniprot id: A0A0B6F4D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

161899:CSING RS00610
gene id: 161899:CSING_RS00610
uniprot id: A0A0B6ESC8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

161899:CSING RS04310
gene id: 161899:CSING_RS04310
uniprot id: A0A0B6F1U0
names: Similarity
messages: Belongs to the FPG family.

161899:CSING RS10635
gene id: 161899:CSING_RS10635
uniprot id: A0A0B6F6P9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

161899:CSING RS05325
gene id: 161899:CSING_RS05325
uniprot id: A0A0B6F0E0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

161899:CSING RS03555
gene id: 161899:CSING_RS03555
uniprot id: A0A0B6ETY3
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

161899:CSING RS05540
gene id: 161899:CSING_RS05540
uniprot id: A0A0B6F0G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

161899:CSING RS02745
gene id: 161899:CSING_RS02745
uniprot id: A0A0B6ENS3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

161899:CSING RS00220
gene id: 161899:CSING_RS00220
uniprot id: A0A0B6ES73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

161899:CSING RS01945
gene id: 161899:CSING_RS01945
uniprot id: A0A0B6F0H9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

161899:CSING RS06225
gene id: 161899:CSING_RS06225
uniprot id: A0A0B6F451
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

161899:CSING RS09140
gene id: 161899:CSING_RS09140
uniprot id: A0A0B6F2E5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05935
gene id: 161899:CSING_RS05935
uniprot id: A0A0B6F0M8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

161899:CSING RS08590
gene id: 161899:CSING_RS08590
uniprot id: A0A0B6ERX4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06390
gene id: 161899:CSING_RS06390
uniprot id: A0A0B6EVI0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

161899:CSING RS05060
gene id: 161899:CSING_RS05060
uniprot id: A0A0B6F3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS00170
gene id: 161899:CSING_RS00170
uniprot id: A0A0B6ES66
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07725
gene id: 161899:CSING_RS07725
uniprot id: A0A0B6EWD3
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

161899:CSING RS01940
gene id: 161899:CSING_RS01940
uniprot id: A0A0B6EYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

161899:CSING RS09090
gene id: 161899:CSING_RS09090
uniprot id: A0A0B6EX34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

161899:CSING RS11540
gene id: 161899:CSING_RS11540
uniprot id: A0A0B6F3T5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

161899:CSING RS04180
gene id: 161899:CSING_RS04180
uniprot id: A0A0B6F1R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

161899:CSING RS08335
gene id: 161899:CSING_RS08335
uniprot id: A0A0B6F5C5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

161899:CSING RS02555
gene id: 161899:CSING_RS02555
uniprot id: A0A0B6EYV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

161899:CSING RS01565
gene id: 161899:CSING_RS01565
uniprot id: A0A0B6ESW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

161899:CSING RS09755
gene id: 161899:CSING_RS09755
uniprot id: A0A0B6F4Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

161899:CSING RS06750
gene id: 161899:CSING_RS06750
uniprot id: A0A0B6F122
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

161899:CSING RS07885
gene id: 161899:CSING_RS07885
uniprot id: A0A0B6F3Z5
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

161899:CSING RS14070
gene id: 161899:CSING_RS14070
uniprot id: A0A0B6F4C8
names: Similarity
messages: Belongs to the peptidase C40 family.

161899:CSING RS06515
gene id: 161899:CSING_RS06515
uniprot id: A0A0B6EVK5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00970
gene id: 161899:CSING_RS00970
uniprot id: A0A0B6EXS1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

161899:CSING RS08045
gene id: 161899:CSING_RS08045
uniprot id: A0A0B6ERN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

161899:CSING RS07990
gene id: 161899:CSING_RS07990
uniprot id: A0A0B6F579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

161899:CSING RS08955
gene id: 161899:CSING_RS08955
uniprot id: A0A0B6F5P2
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

161899:CSING RS10555
gene id: 161899:CSING_RS10555
uniprot id: A0A0B6F5J5
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

161899:CSING RS10300
gene id: 161899:CSING_RS10300
uniprot id: A0A0B6EXX0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

161899:CSING RS06720
gene id: 161899:CSING_RS06720
uniprot id: A0A0B6EVP5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

161899:CSING RS09490
gene id: 161899:CSING_RS09490
uniprot id: A0A0B6ESH2
names: Similarity
messages: Belongs to the OsmC/Ohr family.

161899:CSING RS06735
gene id: 161899:CSING_RS06735
uniprot id: A0A0B6F4E9
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

161899:CSING RS02895
gene id: 161899:CSING_RS02895
uniprot id: A0A0B6EZ03
names: Similarity
messages: Belongs to the citrate synthase family.

161899:CSING RS07840
gene id: 161899:CSING_RS07840
uniprot id: A0A0B6F554
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

161899:CSING RS08845
gene id: 161899:CSING_RS08845
uniprot id: A0A0B6F282
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

161899:CSING RS07195
gene id: 161899:CSING_RS07195
uniprot id: A0A0B6F3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

161899:CSING RS01365
gene id: 161899:CSING_RS01365
uniprot id: A0A0B6EXZ8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

161899:CSING RS06450
gene id: 161899:CSING_RS06450
uniprot id: A0A0B6F317
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

161899:CSING RS08455
gene id: 161899:CSING_RS08455
uniprot id: A0A0B6F484
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

161899:CSING RS02900
gene id: 161899:CSING_RS02900
uniprot id: A0A0B6F147
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

161899:CSING RS01295
gene id: 161899:CSING_RS01295
uniprot id: A0A0B6F046
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

161899:CSING RS07230
gene id: 161899:CSING_RS07230
uniprot id: A0A0B6ER76
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

161899:CSING RS00415
gene id: 161899:CSING_RS00415
uniprot id: A0A0B6ES99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

161899:CSING RS06350
gene id: 161899:CSING_RS06350
uniprot id: A0A0B6F2Z6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02715
gene id: 161899:CSING_RS02715
uniprot id: A0A0B6F279
names: Similarity
messages: Belongs to the pyruvate kinase family.

161899:CSING RS10690
gene id: 161899:CSING_RS10690
uniprot id: A0A0B6F5L7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

161899:CSING RS07200
gene id: 161899:CSING_RS07200
uniprot id: A0A0B6F4Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

161899:CSING RS07165
gene id: 161899:CSING_RS07165
uniprot id: A0A0B6F1C3
names: Similarity
messages: Belongs to the UPF0434 family.

161899:CSING RS04995
gene id: 161899:CSING_RS04995
uniprot id: A0A0B6EUT9
names: Similarity
messages: Belongs to the FBPase class 2 family.

161899:CSING RS02290
gene id: 161899:CSING_RS02290
uniprot id: A0A0B6EYM9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS00340
gene id: 161899:CSING_RS00340
uniprot id: A0A0B6ES89
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

161899:CSING RS07745
gene id: 161899:CSING_RS07745
uniprot id: A0A0B6ERK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

161899:CSING RS12415
gene id: 161899:CSING_RS12415
uniprot id: A0A0B6F6F4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12235
gene id: 161899:CSING_RS12235
uniprot id: A0A0B6EU48
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

161899:CSING RS09050
gene id: 161899:CSING_RS09050
uniprot id: A0A0B6F4J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

161899:CSING RS07995
gene id: 161899:CSING_RS07995
uniprot id: A0A0B6ERN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

161899:CSING RS08355
gene id: 161899:CSING_RS08355
uniprot id: A0A0B6F469
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

161899:CSING RS10060
gene id: 161899:CSING_RS10060
uniprot id: A0A0B6F5A4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

161899:CSING RS10035
gene id: 161899:CSING_RS10035
uniprot id: A0A0B6F325
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

161899:CSING RS10180
gene id: 161899:CSING_RS10180
uniprot id: A0A0B6F379
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

161899:CSING RS07270
gene id: 161899:CSING_RS07270
uniprot id: A0A0B6F3J3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

161899:CSING RS11655
gene id: 161899:CSING_RS11655
uniprot id: A0A0B6ETP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

161899:CSING RS08310
gene id: 161899:CSING_RS08310
uniprot id: A0A0B6F5C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

161899:CSING RS02790
gene id: 161899:CSING_RS02790
uniprot id: A0A0B6ETM0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

161899:CSING RS07515
gene id: 161899:CSING_RS07515
uniprot id: A0A0B6EW78
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

161899:CSING RS02335
gene id: 161899:CSING_RS02335
uniprot id: A0A0B6ETC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

161899:CSING RS12145
gene id: 161899:CSING_RS12145
uniprot id: A0A0B6F475
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

161899:CSING RS10195
gene id: 161899:CSING_RS10195
uniprot id: A0A0B6ET16
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

161899:CSING RS10185
gene id: 161899:CSING_RS10185
uniprot id: A0A0B6F5E3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS12820
gene id: 161899:CSING_RS12820
uniprot id: A0A0B6F4N6
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

161899:CSING RS01350
gene id: 161899:CSING_RS01350
uniprot id: A0A0B6F1D4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07825
gene id: 161899:CSING_RS07825
uniprot id: A0A0B6EWE7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00365
gene id: 161899:CSING_RS00365
uniprot id: A0A0B6ES94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS08240
gene id: 161899:CSING_RS08240
uniprot id: A0A0B6ERR5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

161899:CSING RS06865
gene id: 161899:CSING_RS06865
uniprot id: A0A0B6EQY9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09840
gene id: 161899:CSING_RS09840
uniprot id: A0A0B6F2X4
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

161899:CSING RS01905
gene id: 161899:CSING_RS01905
uniprot id: A0A0B6EYD9
names: Similarity
messages: Belongs to the aminoglycoside phosphotransferase family.

161899:CSING RS10030
gene id: 161899:CSING_RS10030
uniprot id: A0A0B6EXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

161899:CSING RS04240
gene id: 161899:CSING_RS04240
uniprot id: A0A0B6EPH4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

161899:CSING RS01215
gene id: 161899:CSING_RS01215
uniprot id: A0A0B6EMR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

161899:CSING RS10510
gene id: 161899:CSING_RS10510
uniprot id: A0A0B6ET53
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06500
gene id: 161899:CSING_RS06500
uniprot id: A0A0B6F328
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

161899:CSING RS11015
gene id: 161899:CSING_RS11015
uniprot id: A0A0B6F3J2
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

161899:CSING RS09290
gene id: 161899:CSING_RS09290
uniprot id: A0A0B6F5W0
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

161899:CSING RS08875
gene id: 161899:CSING_RS08875
uniprot id: A0A0B6F4F8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07425
gene id: 161899:CSING_RS07425
uniprot id: A0A0B6F3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

161899:CSING RS04500
gene id: 161899:CSING_RS04500
uniprot id: A0A0B6EZU9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

161899:CSING RS06375
gene id: 161899:CSING_RS06375
uniprot id: A0A0B6F301
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS10955
gene id: 161899:CSING_RS10955
uniprot id: A0A0B6EY69
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

161899:CSING RS04245
gene id: 161899:CSING_RS04245
uniprot id: A0A0B6EUB3
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09345
gene id: 161899:CSING_RS09345
uniprot id: A0A0B6ESD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

161899:CSING RS02025
gene id: 161899:CSING_RS02025
uniprot id: A0A0B6EN85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

161899:CSING RS07055
gene id: 161899:CSING_RS07055
uniprot id: A0A0B6F199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

161899:CSING RS06550
gene id: 161899:CSING_RS06550
uniprot id: A0A0B6F337
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

161899:CSING RS08810
gene id: 161899:CSING_RS08810
uniprot id: A0A0B6ES14
names: Similarity
messages: Belongs to the YggT family.

161899:CSING RS12535
gene id: 161899:CSING_RS12535
uniprot id: A0A0B6F4G0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS08290
gene id: 161899:CSING_RS08290
uniprot id: A0A0B6ERS3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06455
gene id: 161899:CSING_RS06455
uniprot id: A0A0B6F497
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

161899:CSING RS11020
gene id: 161899:CSING_RS11020
uniprot id: A0A0B6F5R1
names: Similarity
messages: Belongs to the GARS family.

161899:CSING RS02155
gene id: 161899:CSING_RS02155
uniprot id: A0A0B6ENC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

161899:CSING RS06015
gene id: 161899:CSING_RS06015
uniprot id: A0A0B6F2U6
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

161899:CSING RS03340
gene id: 161899:CSING_RS03340
uniprot id: A0A0B6EZ68
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

161899:CSING RS11455
gene id: 161899:CSING_RS11455
uniprot id: A0A0B6ETK2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09785
gene id: 161899:CSING_RS09785
uniprot id: A0A0B6F663
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00550
gene id: 161899:CSING_RS00550
uniprot id: A0A0B6EZS5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-68 and Arg-71) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

161899:CSING RS04275
gene id: 161899:CSING_RS04275
uniprot id: A0A0B6EUB9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

161899:CSING RS09855
gene id: 161899:CSING_RS09855
uniprot id: A0A0B6ESS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS11195
gene id: 161899:CSING_RS11195
uniprot id: A0A0B6F5T8
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

161899:CSING RS06490
gene id: 161899:CSING_RS06490
uniprot id: A0A0B6EVK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

161899:CSING RS07865
gene id: 161899:CSING_RS07865
uniprot id: A0A0B6F559
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

161899:CSING RS04435
gene id: 161899:CSING_RS04435
uniprot id: A0A0B6F1X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

161899:CSING RS08005
gene id: 161899:CSING_RS08005
uniprot id: A0A0B6F1V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

161899:CSING RS12410
gene id: 161899:CSING_RS12410
uniprot id: A0A0B6F4C7
names: Similarity
messages: Belongs to the thioredoxin family.

161899:CSING RS05800
gene id: 161899:CSING_RS05800
uniprot id: A0A0B6EQF3
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

161899:CSING RS02770
gene id: 161899:CSING_RS02770
uniprot id: A0A0B6EYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

161899:CSING RS03600
gene id: 161899:CSING_RS03600
uniprot id: A0A0B6EP53
names: Similarity
messages: Belongs to the thymidylate kinase family.

161899:CSING RS02505
gene id: 161899:CSING_RS02505
uniprot id: A0A0B6EYS0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS11080
gene id: 161899:CSING_RS11080
uniprot id: A0A0B6F6X3
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

161899:CSING RS00015
gene id: 161899:CSING_RS00015
uniprot id: A0A0B6F0R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

161899:CSING RS10805
gene id: 161899:CSING_RS10805
uniprot id: A0A0B6EY35
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

161899:CSING RS03070
gene id: 161899:CSING_RS03070
uniprot id: A0A0B6EZ28
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

161899:CSING RS12840
gene id: 161899:CSING_RS12840
uniprot id: A0A0B6EZC0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10280
gene id: 161899:CSING_RS10280
uniprot id: A0A0B6F394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS08205
gene id: 161899:CSING_RS08205
uniprot id: A0A0B6F1Y4
names: Similarity
messages: Belongs to the MQO family.

161899:CSING RS06700
gene id: 161899:CSING_RS06700
uniprot id: A0A0B6F110
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

161899:CSING RS02340
gene id: 161899:CSING_RS02340
uniprot id: A0A0B6EYP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

161899:CSING RS01385
gene id: 161899:CSING_RS01385
uniprot id: A0A0B6EST4
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

161899:CSING RS11050
gene id: 161899:CSING_RS11050
uniprot id: A0A0B6F6W8
names: Similarity
messages: Belongs to the TPP enzyme family.

161899:CSING RS11140
gene id: 161899:CSING_RS11140
uniprot id: A0A0B6F3K8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

161899:CSING RS08865
gene id: 161899:CSING_RS08865
uniprot id: A0A0B6EWY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

161899:CSING RS08095
gene id: 161899:CSING_RS08095
uniprot id: A0A0B6ERP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

161899:CSING RS01500
gene id: 161899:CSING_RS01500
uniprot id: A0A0B6F1G0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11465
gene id: 161899:CSING_RS11465
uniprot id: A0A0B6F3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

161899:CSING RS04305
gene id: 161899:CSING_RS04305
uniprot id: A0A0B6EZQ3
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

161899:CSING RS10910
gene id: 161899:CSING_RS10910
uniprot id: A0A0B6F3H7
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

161899:CSING RS03425
gene id: 161899:CSING_RS03425
uniprot id: A0A0B6EP21
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

161899:CSING RS06545
gene id: 161899:CSING_RS06545
uniprot id: A0A0B6F0X5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

161899:CSING RS04385
gene id: 161899:CSING_RS04385
uniprot id: A0A0B6F1V8
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

161899:CSING RS10905
gene id: 161899:CSING_RS10905
uniprot id: A0A0B6EY58
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

161899:CSING RS05880
gene id: 161899:CSING_RS05880
uniprot id: A0A0B6EV84
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

161899:CSING RS09165
gene id: 161899:CSING_RS09165
uniprot id: A0A0B6F4L8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

161899:CSING RS03970
gene id: 161899:CSING_RS03970
uniprot id: A0A0B6F1M7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

161899:CSING RS02730
gene id: 161899:CSING_RS02730
uniprot id: A0A0B6EYX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

161899:CSING RS12585
gene id: 161899:CSING_RS12585
uniprot id: A0A0B6F4H5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS02345
gene id: 161899:CSING_RS02345
uniprot id: A0A0B6F0R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

161899:CSING RS03680
gene id: 161899:CSING_RS03680
uniprot id: A0A0B6EU08
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

161899:CSING RS02940
gene id: 161899:CSING_RS02940
uniprot id: A0A0B6ETN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

161899:CSING RS04800
gene id: 161899:CSING_RS04800
uniprot id: A0A0B6F019
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

161899:CSING RS02835
gene id: 161899:CSING_RS02835
uniprot id: A0A0B6ENT7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08605
gene id: 161899:CSING_RS08605
uniprot id: A0A0B6F4A9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

161899:CSING RS10890
gene id: 161899:CSING_RS10890
uniprot id: A0A0B6F5P3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

161899:CSING RS01065
gene id: 161899:CSING_RS01065
uniprot id: A0A0B6EXT6
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

161899:CSING RS02160
gene id: 161899:CSING_RS02160
uniprot id: A0A0B6ET78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

161899:CSING RS05590
gene id: 161899:CSING_RS05590
uniprot id: A0A0B6F0H5
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

161899:CSING RS10575
gene id: 161899:CSING_RS10575
uniprot id: A0A0B6F3D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

161899:CSING RS07690
gene id: 161899:CSING_RS07690
uniprot id: A0A0B6F531
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

161899:CSING RS10680
gene id: 161899:CSING_RS10680
uniprot id: A0A0B6EY17
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12855
gene id: 161899:CSING_RS12855
uniprot id: A0A0B6F7X8
names: Similarity
messages: Belongs to the peptidase M1 family.

161899:CSING RS06975
gene id: 161899:CSING_RS06975
uniprot id: A0A0B6F179
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

161899:CSING RS02970
gene id: 161899:CSING_RS02970
uniprot id: A0A0B6EZ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

161899:CSING RS01750
gene id: 161899:CSING_RS01750
uniprot id: A0A0B6F1K9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08250
gene id: 161899:CSING_RS08250
uniprot id: A0A0B6F1Z1
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02825
gene id: 161899:CSING_RS02825
uniprot id: A0A0B6F134
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS08440
gene id: 161899:CSING_RS08440
uniprot id: A0A0B6ERU8
names: Similarity
messages: Belongs to the P(II) protein family.

161899:CSING RS05570
gene id: 161899:CSING_RS05570
uniprot id: A0A0B6F2M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS02190
gene id: 161899:CSING_RS02190
uniprot id: A0A0B6EYK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

161899:CSING RS08315
gene id: 161899:CSING_RS08315
uniprot id: A0A0B6ERS8
names: Similarity
messages: Belongs to the DprA/Smf family.

161899:CSING RS03500
gene id: 161899:CSING_RS03500
uniprot id: A0A0B6EP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS12875
gene id: 161899:CSING_RS12875
uniprot id: A0A0B6EZC5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

161899:CSING RS06470
gene id: 161899:CSING_RS06470
uniprot id: A0A0B6F0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

161899:CSING RS03085
gene id: 161899:CSING_RS03085
uniprot id: A0A0B6ENW7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

161899:CSING RS12435
gene id: 161899:CSING_RS12435
uniprot id: A0A0B6F4D4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

161899:CSING RS09195
gene id: 161899:CSING_RS09195
uniprot id: A0A0B6F4M4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS07560
gene id: 161899:CSING_RS07560
uniprot id: A0A0B6ERH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

161899:CSING RS09825
gene id: 161899:CSING_RS09825
uniprot id: A0A0B6F675
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11290
gene id: 161899:CSING_RS11290
uniprot id: A0A0B6F3N2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

161899:CSING RS06395
gene id: 161899:CSING_RS06395
uniprot id: A0A0B6F0U5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

161899:CSING RS10010
gene id: 161899:CSING_RS10010
uniprot id: A0A0B6F318
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS04360
gene id: 161899:CSING_RS04360
uniprot id: A0A0B6F1V3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS05670
gene id: 161899:CSING_RS05670
uniprot id: A0A0B6F2N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

161899:CSING RS03715
gene id: 161899:CSING_RS03715
uniprot id: A0A0B6F1H8
names: Similarity
messages: Belongs to the DEAD box helicase family.

161899:CSING RS03355
gene id: 161899:CSING_RS03355
uniprot id: A0A0B6ETU8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

161899:CSING RS10825
gene id: 161899:CSING_RS10825
uniprot id: A0A0B6ET93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

161899:CSING RS07280
gene id: 161899:CSING_RS07280
uniprot id: A0A0B6ER91
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11325
gene id: 161899:CSING_RS11325
uniprot id: A0A0B6F720
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

161899:CSING RS07575
gene id: 161899:CSING_RS07575
uniprot id: A0A0B6F3U2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

161899:CSING RS12175
gene id: 161899:CSING_RS12175
uniprot id: A0A0B6F6B4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS04730
gene id: 161899:CSING_RS04730
uniprot id: A0A0B6F241
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

161899:CSING RS00085
gene id: 161899:CSING_RS00085
uniprot id: A0A0B6F0S4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08465
gene id: 161899:CSING_RS08465
uniprot id: A0A0B6ERV1
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03990
gene id: 161899:CSING_RS03990
uniprot id: A0A0B6EZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

161899:CSING RS09400
gene id: 161899:CSING_RS09400
uniprot id: A0A0B6F2L9
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

161899:CSING RS11335
gene id: 161899:CSING_RS11335
uniprot id: A0A0B6EYE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

161899:CSING RS04155
gene id: 161899:CSING_RS04155
uniprot id: A0A0B6F1Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS12665
gene id: 161899:CSING_RS12665
uniprot id: A0A0B6F4K6
names: Similarity
messages: Belongs to the YjdM family.

161899:CSING RS11935
gene id: 161899:CSING_RS11935
uniprot id: A0A0B6F671
names: Similarity
messages: Belongs to the universal stress protein A family.

161899:CSING RS11830
gene id: 161899:CSING_RS11830
uniprot id: A0A0B6ETT7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08460
gene id: 161899:CSING_RS08460
uniprot id: A0A0B6F5E9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11200
gene id: 161899:CSING_RS11200
uniprot id: A0A0B6F6Z7
names: Similarity
messages: Belongs to the Nth/MutY family.

161899:CSING RS02585
gene id: 161899:CSING_RS02585
uniprot id: A0A0B6F0Y9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

161899:CSING RS10475
gene id: 161899:CSING_RS10475
uniprot id: A0A0B6F5I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS09745
gene id: 161899:CSING_RS09745
uniprot id: A0A0B6EXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

161899:CSING RS07545
gene id: 161899:CSING_RS07545
uniprot id: A0A0B6F1L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

161899:CSING RS04990
gene id: 161899:CSING_RS04990
uniprot id: A0A0B6EQ15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

161899:CSING RS05990
gene id: 161899:CSING_RS05990
uniprot id: A0A0B6F2U2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

161899:CSING RS06445
gene id: 161899:CSING_RS06445
uniprot id: A0A0B6F0V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

161899:CSING RS08960
gene id: 161899:CSING_RS08960
uniprot id: A0A0B6ES41
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

161899:CSING RS10605
gene id: 161899:CSING_RS10605
uniprot id: A0A0B6F5K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

161899:CSING RS06105
gene id: 161899:CSING_RS06105
uniprot id: A0A0B6F428
names: Similarity
messages: Belongs to the UPF0098 family.

161899:CSING RS05150
gene id: 161899:CSING_RS05150
uniprot id: A0A0B6F0B4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

161899:CSING RS12815
gene id: 161899:CSING_RS12815
uniprot id: A0A0B6EZB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

161899:CSING RS02295
gene id: 161899:CSING_RS02295
uniprot id: A0A0B6F0Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS11740
gene id: 161899:CSING_RS11740
uniprot id: A0A0B6F3Y2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS05015
gene id: 161899:CSING_RS05015
uniprot id: A0A0B6EQ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

161899:CSING RS07890
gene id: 161899:CSING_RS07890
uniprot id: A0A0B6F564
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

161899:CSING RS02725
gene id: 161899:CSING_RS02725
uniprot id: A0A0B6ETL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07065
gene id: 161899:CSING_RS07065
uniprot id: A0A0B6F4M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

161899:CSING RS04165
gene id: 161899:CSING_RS04165
uniprot id: A0A0B6EPF7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

161899:CSING RS12515
gene id: 161899:CSING_RS12515
uniprot id: A0A0B6F6H8
names: Similarity
messages: Belongs to the UPF0371 family.

161899:CSING RS08420
gene id: 161899:CSING_RS08420
uniprot id: A0A0B6EWN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

161899:CSING RS01630
gene id: 161899:CSING_RS01630
uniprot id: A0A0B6F1I2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

161899:CSING RS08175
gene id: 161899:CSING_RS08175
uniprot id: A0A0B6EWJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS01435
gene id: 161899:CSING_RS01435
uniprot id: A0A0B6ESU3
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

161899:CSING RS05145
gene id: 161899:CSING_RS05145
uniprot id: A0A0B6EUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

161899:CSING RS11365
gene id: 161899:CSING_RS11365
uniprot id: A0A0B6F3Q0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS09440
gene id: 161899:CSING_RS09440
uniprot id: A0A0B6EXA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

161899:CSING RS07880
gene id: 161899:CSING_RS07880
uniprot id: A0A0B6F1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

161899:CSING RS08985
gene id: 161899:CSING_RS08985
uniprot id: A0A0B6ES45
names: Similarity
messages: Belongs to the peptidase C40 family.

161899:CSING RS11340
gene id: 161899:CSING_RS11340
uniprot id: A0A0B6F3P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

161899:CSING RS06725
gene id: 161899:CSING_RS06725
uniprot id: A0A0B6F116
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

161899:CSING RS10140
gene id: 161899:CSING_RS10140
uniprot id: A0A0B6F6H0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

161899:CSING RS11350
gene id: 161899:CSING_RS11350
uniprot id: A0A0B6F725
names: Similarity
messages: Belongs to the peptidase S13 family.

161899:CSING RS08470
gene id: 161899:CSING_RS08470
uniprot id: A0A0B6EWP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

161899:CSING RS11770
gene id: 161899:CSING_RS11770
uniprot id: A0A0B6F640
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

161899:CSING RS09980
gene id: 161899:CSING_RS09980
uniprot id: A0A0B6EXP7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

161899:CSING RS02235
gene id: 161899:CSING_RS02235
uniprot id: A0A0B6ET98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

161899:CSING RS05335
gene id: 161899:CSING_RS05335
uniprot id: A0A0B6F3P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

161899:CSING RS10085
gene id: 161899:CSING_RS10085
uniprot id: A0A0B6F5C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

161899:CSING RS10335
gene id: 161899:CSING_RS10335
uniprot id: A0A0B6F5G6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

161899:CSING RS06000
gene id: 161899:CSING_RS06000
uniprot id: A0A0B6EQI8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS00710
gene id: 161899:CSING_RS00710
uniprot id: A0A0B6EXN5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10070
gene id: 161899:CSING_RS10070
uniprot id: A0A0B6ET00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

161899:CSING RS07215
gene id: 161899:CSING_RS07215
uniprot id: A0A0B6F1D5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

161899:CSING RS12525
gene id: 161899:CSING_RS12525
uniprot id: A0A0B6EUB5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS01910
gene id: 161899:CSING_RS01910
uniprot id: A0A0B6F0H2
names: Function
messages: Involved in the transposition of the insertion sequence.

161899:CSING RS11155
gene id: 161899:CSING_RS11155
uniprot id: A0A0B6ETF0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07930
gene id: 161899:CSING_RS07930
uniprot id: A0A0B6F1U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS09730
gene id: 161899:CSING_RS09730
uniprot id: A0A0B6F4Z4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

161899:CSING RS09720
gene id: 161899:CSING_RS09720
uniprot id: A0A0B6EXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS11475
gene id: 161899:CSING_RS11475
uniprot id: A0A0B6F742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

161899:CSING RS06420
gene id: 161899:CSING_RS06420
uniprot id: A0A0B6F0V0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

161899:CSING RS07295
gene id: 161899:CSING_RS07295
uniprot id: A0A0B6F3K0
names: Similarity
messages: Belongs to the universal stress protein A family.

161899:CSING RS11135
gene id: 161899:CSING_RS11135
uniprot id: A0A0B6EYA4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

161899:CSING RS02185
gene id: 161899:CSING_RS02185
uniprot id: A0A0B6ET83
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

161899:CSING RS12575
gene id: 161899:CSING_RS12575
uniprot id: A0A0B6EUC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

161899:CSING RS02865
gene id: 161899:CSING_RS02865
uniprot id: A0A0B6ETM8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

161899:CSING RS03450
gene id: 161899:CSING_RS03450
uniprot id: A0A0B6EP27
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS09770
gene id: 161899:CSING_RS09770
uniprot id: A0A0B6EXI3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

161899:CSING RS07525
gene id: 161899:CSING_RS07525
uniprot id: A0A0B6F3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS00955
gene id: 161899:CSING_RS00955
uniprot id: A0A0B6F154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS03300
gene id: 161899:CSING_RS03300
uniprot id: A0A0B6EZ61
names: Cofactor
messages: Binds 1 zinc ion per subunit.

161899:CSING RS10515
gene id: 161899:CSING_RS10515
uniprot id: A0A0B6EXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

161899:CSING RS10840
gene id: 161899:CSING_RS10840
uniprot id: A0A0B6F5N6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

161899:CSING RS03550
gene id: 161899:CSING_RS03550
uniprot id: A0A0B6EP44
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

161899:CSING RS02550
gene id: 161899:CSING_RS02550
uniprot id: A0A0B6ETI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

161899:CSING RS09240
gene id: 161899:CSING_RS09240
uniprot id: A0A0B6F2H2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08430
gene id: 161899:CSING_RS08430
uniprot id: A0A0B6F480
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

161899:CSING RS01285
gene id: 161899:CSING_RS01285
uniprot id: A0A0B6EMS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

161899:CSING RS00985
gene id: 161899:CSING_RS00985
uniprot id: A0A0B6EML5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

161899:CSING RS06370
gene id: 161899:CSING_RS06370
uniprot id: A0A0B6F0U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

161899:CSING RS05115
gene id: 161899:CSING_RS05115
uniprot id: A0A0B6EQ55
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00505
gene id: 161899:CSING_RS00505
uniprot id: A0A0B6EME0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS04325
gene id: 161899:CSING_RS04325
uniprot id: A0A0B6EUD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

161899:CSING RS05090
gene id: 161899:CSING_RS05090
uniprot id: A0A0B6EQ52
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS02475
gene id: 161899:CSING_RS02475
uniprot id: A0A0B6ETF4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

161899:CSING RS03025
gene id: 161899:CSING_RS03025
uniprot id: A0A0B6F169
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

161899:CSING RS00280
gene id: 161899:CSING_RS00280
uniprot id: A0A0B6F0U7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

161899:CSING RS07835
gene id: 161899:CSING_RS07835
uniprot id: A0A0B6F3Y7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10250
gene id: 161899:CSING_RS10250
uniprot id: A0A0B6EXW3
names: Similarity
messages: Belongs to the peptidase M1 family.

161899:CSING RS10715
gene id: 161899:CSING_RS10715
uniprot id: A0A0B6F5M1
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

161899:CSING RS06425
gene id: 161899:CSING_RS06425
uniprot id: A0A0B6F313
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

161899:CSING RS06475
gene id: 161899:CSING_RS06475
uniprot id: A0A0B6F323
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

161899:CSING RS05445
gene id: 161899:CSING_RS05445
uniprot id: A0A0B6F3R5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

161899:CSING RS01100
gene id: 161899:CSING_RS01100
uniprot id: A0A0B6ESM7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

161899:CSING RS01525
gene id: 161899:CSING_RS01525
uniprot id: A0A0B6F1G5
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

161899:CSING RS11205
gene id: 161899:CSING_RS11205
uniprot id: A0A0B6ETF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

161899:CSING RS06635
gene id: 161899:CSING_RS06635
uniprot id: A0A0B6EQU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS03985
gene id: 161899:CSING_RS03985
uniprot id: A0A0B6EU64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

161899:CSING RS08520
gene id: 161899:CSING_RS08520
uniprot id: A0A0B6EWR0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

161899:CSING RS05055
gene id: 161899:CSING_RS05055
uniprot id: A0A0B6F2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS06100
gene id: 161899:CSING_RS06100
uniprot id: A0A0B6F2V7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00045
gene id: 161899:CSING_RS00045
uniprot id: A0A0B6F0S1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

161899:CSING RS11420
gene id: 161899:CSING_RS11420
uniprot id: A0A0B6F5Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

161899:CSING RS02180
gene id: 161899:CSING_RS02180
uniprot id: A0A0B6ENC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS07115
gene id: 161899:CSING_RS07115
uniprot id: A0A0B6F4N4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

161899:CSING RS03945
gene id: 161899:CSING_RS03945
uniprot id: A0A0B6F1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

161899:CSING RS07540
gene id: 161899:CSING_RS07540
uniprot id: A0A0B6EW86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

161899:CSING RS02230
gene id: 161899:CSING_RS02230
uniprot id: A0A0B6ENE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS12720
gene id: 161899:CSING_RS12720
uniprot id: A0A0B6F6Q1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS07390
gene id: 161899:CSING_RS07390
uniprot id: A0A0B6EW41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

161899:CSING RS13440
gene id: 161899:CSING_RS13440
uniprot id: A0A0B6EZC3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

161899:CSING RS05545
gene id: 161899:CSING_RS05545
uniprot id: A0A0B6F2L6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

161899:CSING RS06290
gene id: 161899:CSING_RS06290
uniprot id: A0A0B6EVG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

161899:CSING RS10165
gene id: 161899:CSING_RS10165
uniprot id: A0A0B6F6H5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05640
gene id: 161899:CSING_RS05640
uniprot id: A0A0B6F0I3
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10395
gene id: 161899:CSING_RS10395
uniprot id: A0A0B6F3A8
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

161899:CSING RS11980
gene id: 161899:CSING_RS11980
uniprot id: A0A0B6F436
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS12780
gene id: 161899:CSING_RS12780
uniprot id: A0A0B6F7W8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01210
gene id: 161899:CSING_RS01210
uniprot id: A0A0B6F1A5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

161899:CSING RS07430
gene id: 161899:CSING_RS07430
uniprot id: A0A0B6F4W0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

161899:CSING RS00930
gene id: 161899:CSING_RS00930
uniprot id: A0A0B6F148
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

161899:CSING RS01345
gene id: 161899:CSING_RS01345
uniprot id: A0A0B6F055
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS01115
gene id: 161899:CSING_RS01115
uniprot id: A0A0B6F187
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01085
gene id: 161899:CSING_RS01085
uniprot id: A0A0B6F012
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11705
gene id: 161899:CSING_RS11705
uniprot id: A0A0B6ETQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

161899:CSING RS00890
gene id: 161899:CSING_RS00890
uniprot id: A0A0B6EXR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

161899:CSING RS07300
gene id: 161899:CSING_RS07300
uniprot id: A0A0B6F4T0
names: Similarity
messages: Belongs to the universal stress protein A family.

161899:CSING RS01860
gene id: 161899:CSING_RS01860
uniprot id: A0A0B6EYC6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

161899:CSING RS06295
gene id: 161899:CSING_RS06295
uniprot id: A0A0B6F0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

161899:CSING RS10685
gene id: 161899:CSING_RS10685
uniprot id: A0A0B6F3E7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

161899:CSING RS05265
gene id: 161899:CSING_RS05265
uniprot id: A0A0B6F3N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

161899:CSING RS09340
gene id: 161899:CSING_RS09340
uniprot id: A0A0B6F5X1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

161899:CSING RS03940
gene id: 161899:CSING_RS03940
uniprot id: A0A0B6EZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

161899:CSING RS02050
gene id: 161899:CSING_RS02050
uniprot id: A0A0B6F1S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

161899:CSING RS01390
gene id: 161899:CSING_RS01390
uniprot id: A0A0B6EY05
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

161899:CSING RS12830
gene id: 161899:CSING_RS12830
uniprot id: A0A0B6F7X5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

161899:CSING RS07870
gene id: 161899:CSING_RS07870
uniprot id: A0A0B6ERL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

161899:CSING RS00390
gene id: 161899:CSING_RS00390
uniprot id: A0A0B6ES96
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

161899:CSING RS10365
gene id: 161899:CSING_RS10365
uniprot id: A0A0B6F5G9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06130
gene id: 161899:CSING_RS06130
uniprot id: A0A0B6F432
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

161899:CSING RS00795
gene id: 161899:CSING_RS00795
uniprot id: A0A0B6EZW5
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

161899:CSING RS02880
gene id: 161899:CSING_RS02880
uniprot id: A0A0B6F299
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

161899:CSING RS03685
gene id: 161899:CSING_RS03685
uniprot id: A0A0B6EZC2
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

161899:CSING RS04595
gene id: 161899:CSING_RS04595
uniprot id: A0A0B6EZX5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

161899:CSING RS07980
gene id: 161899:CSING_RS07980
uniprot id: A0A0B6F1V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

161899:CSING RS04715
gene id: 161899:CSING_RS04715
uniprot id: A0A0B6EPU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

161899:CSING RS03195
gene id: 161899:CSING_RS03195
uniprot id: A0A0B6EZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

161899:CSING RS06855
gene id: 161899:CSING_RS06855
uniprot id: A0A0B6F3A2
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

161899:CSING RS07380
gene id: 161899:CSING_RS07380
uniprot id: A0A0B6F4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

161899:CSING RS12740
gene id: 161899:CSING_RS12740
uniprot id: A0A0B6EZA8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS10600
gene id: 161899:CSING_RS10600
uniprot id: A0A0B6F3D7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

161899:CSING RS05425
gene id: 161899:CSING_RS05425
uniprot id: A0A0B6EQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

161899:CSING RS05080
gene id: 161899:CSING_RS05080
uniprot id: A0A0B6F2E6
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11745
gene id: 161899:CSING_RS11745
uniprot id: A0A0B6F636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

161899:CSING RS01110
gene id: 161899:CSING_RS01110
uniprot id: A0A0B6F016
names: Similarity
messages: Belongs to the thioesterase family.

161899:CSING RS02675
gene id: 161899:CSING_RS02675
uniprot id: A0A0B6ETK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

161899:CSING RS00835
gene id: 161899:CSING_RS00835
uniprot id: A0A0B6ESH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

161899:CSING RS03475
gene id: 161899:CSING_RS03475
uniprot id: A0A0B6EP31
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

161899:CSING RS04585
gene id: 161899:CSING_RS04585
uniprot id: A0A0B6EPR1
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

161899:CSING RS06355
gene id: 161899:CSING_RS06355
uniprot id: A0A0B6F477
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

161899:CSING RS12490
gene id: 161899:CSING_RS12490
uniprot id: A0A0B6F6H2
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

161899:CSING RS10540
gene id: 161899:CSING_RS10540
uniprot id: A0A0B6ET57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

161899:CSING RS06485
gene id: 161899:CSING_RS06485
uniprot id: A0A0B6EQR5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02285
gene id: 161899:CSING_RS02285
uniprot id: A0A0B6ETB1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

161899:CSING RS11690
gene id: 161899:CSING_RS11690
uniprot id: A0A0B6F3W9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

161899:CSING RS10320
gene id: 161899:CSING_RS10320
uniprot id: A0A0B6ET32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

161899:CSING RS09055
gene id: 161899:CSING_RS09055
uniprot id: A0A0B6F5Q9
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

161899:CSING RS09875
gene id: 161899:CSING_RS09875
uniprot id: A0A0B6F687
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

161899:CSING RS10470
gene id: 161899:CSING_RS10470
uniprot id: A0A0B6F3B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS12440
gene id: 161899:CSING_RS12440
uniprot id: A0A0B6F6F9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

161899:CSING RS08915
gene id: 161899:CSING_RS08915
uniprot id: A0A0B6EWZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

161899:CSING RS12770
gene id: 161899:CSING_RS12770
uniprot id: A0A0B6F4M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

161899:CSING RS01780
gene id: 161899:CSING_RS01780
uniprot id: A0A0B6EN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

161899:CSING RS02260
gene id: 161899:CSING_RS02260
uniprot id: A0A0B6ETA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

161899:CSING RS06790
gene id: 161899:CSING_RS06790
uniprot id: A0A0B6EQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

161899:CSING RS01900
gene id: 161899:CSING_RS01900
uniprot id: A0A0B6ET28
names: Function
messages: Involved in the transposition of the insertion sequence.

161899:CSING RS13660
gene id: 161899:CSING_RS13660
uniprot id: A0A0B6F3I8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

161899:CSING RS11070
gene id: 161899:CSING_RS11070
uniprot id: A0A0B6F3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

161899:CSING RS10610
gene id: 161899:CSING_RS10610
uniprot id: A0A0B6F6P5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

161899:CSING RS02510
gene id: 161899:CSING_RS02510
uniprot id: A0A0B6F0U8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

161899:CSING RS00125
gene id: 161899:CSING_RS00125
uniprot id: A0A0B6EXE9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03585
gene id: 161899:CSING_RS03585
uniprot id: A0A0B6EZA5
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

161899:CSING RS11235
gene id: 161899:CSING_RS11235
uniprot id: A0A0B6EYC4
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06885
gene id: 161899:CSING_RS06885
uniprot id: A0A0B6F4I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS07905
gene id: 161899:CSING_RS07905
uniprot id: A0A0B6F1U5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS04135
gene id: 161899:CSING_RS04135
uniprot id: A0A0B6F2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

161899:CSING RS07335
gene id: 161899:CSING_RS07335
uniprot id: A0A0B6EW25
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12765
gene id: 161899:CSING_RS12765
uniprot id: A0A0B6EZB1
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

161899:CSING RS01710
gene id: 161899:CSING_RS01710
uniprot id: A0A0B6ESY9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05905
gene id: 161899:CSING_RS05905
uniprot id: A0A0B6EV87
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

161899:CSING RS06385
gene id: 161899:CSING_RS06385
uniprot id: A0A0B6EQQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS10835
gene id: 161899:CSING_RS10835
uniprot id: A0A0B6F3G6
names: Similarity
messages: Belongs to the PstS family.

161899:CSING RS00440
gene id: 161899:CSING_RS00440
uniprot id: A0A0B6EXJ3
names: Similarity
messages: Belongs to the peptidase M13 family.

161899:CSING RS03325
gene id: 161899:CSING_RS03325
uniprot id: A0A0B6F2H5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08540
gene id: 161899:CSING_RS08540
uniprot id: A0A0B6ERW4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

161899:CSING RS12350
gene id: 161899:CSING_RS12350
uniprot id: A0A0B6F6E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

161899:CSING RS00925
gene id: 161899:CSING_RS00925
uniprot id: A0A0B6EZY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

161899:CSING RS06785
gene id: 161899:CSING_RS06785
uniprot id: A0A0B6F4G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

161899:CSING RS08040
gene id: 161899:CSING_RS08040
uniprot id: A0A0B6F585
names: Similarity
messages: Belongs to the YciI family.

161899:CSING RS06585
gene id: 161899:CSING_RS06585
uniprot id: A0A0B6EQT3
names: Similarity
messages: Belongs to the UPF0237 family.

161899:CSING RS05420
gene id: 161899:CSING_RS05420
uniprot id: A0A0B6F3R2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

161899:CSING RS02985
gene id: 161899:CSING_RS02985
uniprot id: A0A0B6ENV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

161899:CSING RS05415
gene id: 161899:CSING_RS05415
uniprot id: A0A0B6F2J7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

161899:CSING RS09420
gene id: 161899:CSING_RS09420
uniprot id: A0A0B6F2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

161899:CSING RS08485
gene id: 161899:CSING_RS08485
uniprot id: A0A0B6F5F5
names: Similarity
messages: Belongs to the acylphosphatase family.

161899:CSING RS01315
gene id: 161899:CSING_RS01315
uniprot id: A0A0B6EXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Periplasm

161899:CSING RS05575
gene id: 161899:CSING_RS05575
uniprot id: A0A0B6F3T4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

161899:CSING RS05930
gene id: 161899:CSING_RS05930
uniprot id: A0A0B6EV93
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

161899:CSING RS06330
gene id: 161899:CSING_RS06330
uniprot id: A0A0B6F471
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

161899:CSING RS09780
gene id: 161899:CSING_RS09780
uniprot id: A0A0B6F501
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

161899:CSING RS00725
gene id: 161899:CSING_RS00725
uniprot id: A0A0B6EMH1
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03740
gene id: 161899:CSING_RS03740
uniprot id: A0A0B6F1I4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

161899:CSING RS07160
gene id: 161899:CSING_RS07160
uniprot id: A0A0B6EVY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS04550
gene id: 161899:CSING_RS04550
uniprot id: A0A0B6F204
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

161899:CSING RS05695
gene id: 161899:CSING_RS05695
uniprot id: A0A0B6F2P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

161899:CSING RS05450
gene id: 161899:CSING_RS05450
uniprot id: A0A0B6EQ97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

161899:CSING RS02255
gene id: 161899:CSING_RS02255
uniprot id: A0A0B6ENE9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11430
gene id: 161899:CSING_RS11430
uniprot id: A0A0B6ETJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

161899:CSING RS12120
gene id: 161899:CSING_RS12120
uniprot id: A0A0B6F468
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

161899:CSING RS09740
gene id: 161899:CSING_RS09740
uniprot id: A0A0B6ESP1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

161899:CSING RS09335
gene id: 161899:CSING_RS09335
uniprot id: A0A0B6F4Q7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

161899:CSING RS00935
gene id: 161899:CSING_RS00935
uniprot id: A0A0B6EMK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

161899:CSING RS07470
gene id: 161899:CSING_RS07470
uniprot id: A0A0B6F1J1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

161899:CSING RS06675
gene id: 161899:CSING_RS06675
uniprot id: A0A0B6F104
names: Similarity
messages: Belongs to the UPF0098 family.

161899:CSING RS12425
gene id: 161899:CSING_RS12425
uniprot id: A0A0B6EU91
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS00235
gene id: 161899:CSING_RS00235
uniprot id: A0A0B6EMA5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01130
gene id: 161899:CSING_RS01130
uniprot id: A0A0B6EXV0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS03545
gene id: 161899:CSING_RS03545
uniprot id: A0A0B6F2L8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

161899:CSING RS09775
gene id: 161899:CSING_RS09775
uniprot id: A0A0B6F2V9
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

161899:CSING RS11265
gene id: 161899:CSING_RS11265
uniprot id: A0A0B6F3M9
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05675
gene id: 161899:CSING_RS05675
uniprot id: A0A0B6F3U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

161899:CSING RS04355
gene id: 161899:CSING_RS04355
uniprot id: A0A0B6EZR5
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS12260
gene id: 161899:CSING_RS12260
uniprot id: A0A0B6EU53
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

161899:CSING RS01790
gene id: 161899:CSING_RS01790
uniprot id: A0A0B6EYA7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

161899:CSING RS04380
gene id: 161899:CSING_RS04380
uniprot id: A0A0B6EZS0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07375
gene id: 161899:CSING_RS07375
uniprot id: A0A0B6F3L5
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

161899:CSING RS11355
gene id: 161899:CSING_RS11355
uniprot id: A0A0B6ETI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

161899:CSING RS11495
gene id: 161899:CSING_RS11495
uniprot id: A0A0B6F5Z5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

161899:CSING RS10160
gene id: 161899:CSING_RS10160
uniprot id: A0A0B6F5D9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

161899:CSING RS03440
gene id: 161899:CSING_RS03440
uniprot id: A0A0B6F1D7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

161899:CSING RS09680
gene id: 161899:CSING_RS09680
uniprot id: A0A0B6F4Y6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

161899:CSING RS00305
gene id: 161899:CSING_RS00305
uniprot id: A0A0B6F0V2
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

161899:CSING RS05305
gene id: 161899:CSING_RS05305
uniprot id: A0A0B6F2I1
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

161899:CSING RS07395
gene id: 161899:CSING_RS07395
uniprot id: A0A0B6F1H4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS01495
gene id: 161899:CSING_RS01495
uniprot id: A0A0B6F083
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

161899:CSING RS03670
gene id: 161899:CSING_RS03670
uniprot id: A0A0B6F2P4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

161899:CSING RS00975
gene id: 161899:CSING_RS00975
uniprot id: A0A0B6EZZ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS05555
gene id: 161899:CSING_RS05555
uniprot id: A0A0B6EQB0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

161899:CSING RS04525
gene id: 161899:CSING_RS04525
uniprot id: A0A0B6F1Z8
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS02840
gene id: 161899:CSING_RS02840
uniprot id: A0A0B6ETM5
names: Similarity
messages: Belongs to the peptidase S11 family.

161899:CSING RS03455
gene id: 161899:CSING_RS03455
uniprot id: A0A0B6ETW6
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS05775
gene id: 161899:CSING_RS05775
uniprot id: A0A0B6EQE9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

161899:CSING RS01950
gene id: 161899:CSING_RS01950
uniprot id: A0A0B6F1Q0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

161899:CSING RS10175
gene id: 161899:CSING_RS10175
uniprot id: A0A0B6EXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

161899:CSING RS09930
gene id: 161899:CSING_RS09930
uniprot id: A0A0B6ESU4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

161899:CSING RS05995
gene id: 161899:CSING_RS05995
uniprot id: A0A0B6F408
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

161899:CSING RS09985
gene id: 161899:CSING_RS09985
uniprot id: A0A0B6F311
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

161899:CSING RS03615
gene id: 161899:CSING_RS03615
uniprot id: A0A0B6F1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

161899:CSING RS08015
gene id: 161899:CSING_RS08015
uniprot id: A0A0B6F583
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS11435
gene id: 161899:CSING_RS11435
uniprot id: A0A0B6EYG7
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08885
gene id: 161899:CSING_RS08885
uniprot id: A0A0B6ES28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

161899:CSING RS08675
gene id: 161899:CSING_RS08675
uniprot id: A0A0B6F253
names: Similarity
messages: Belongs to the IMPACT family.

161899:CSING RS00720
gene id: 161899:CSING_RS00720
uniprot id: A0A0B6F114
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS06930
gene id: 161899:CSING_RS06930
uniprot id: A0A0B6F3C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

161899:CSING RS09555
gene id: 161899:CSING_RS09555
uniprot id: A0A0B6F2Q4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

161899:CSING RS08400
gene id: 161899:CSING_RS08400
uniprot id: A0A0B6F213
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

161899:CSING RS04450
gene id: 161899:CSING_RS04450
uniprot id: A0A0B6EUF1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

161899:CSING RS07185
gene id: 161899:CSING_RS07185
uniprot id: A0A0B6EVY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

161899:CSING RS08680
gene id: 161899:CSING_RS08680
uniprot id: A0A0B6F4C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

161899:CSING RS05980
gene id: 161899:CSING_RS05980
uniprot id: A0A0B6EVA1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS06050
gene id: 161899:CSING_RS06050
uniprot id: A0A0B6EQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

161899:CSING RS11125
gene id: 161899:CSING_RS11125
uniprot id: A0A0B6F5S3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS06730
gene id: 161899:CSING_RS06730
uniprot id: A0A0B6F371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

161899:CSING RS05105
gene id: 161899:CSING_RS05105
uniprot id: A0A0B6F2F0
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01715
gene id: 161899:CSING_RS01715
uniprot id: A0A0B6EY88
names: Similarity
messages: Belongs to the ABC transporter superfamily.

161899:CSING RS10700
gene id: 161899:CSING_RS10700
uniprot id: A0A0B6ET77
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS01725
gene id: 161899:CSING_RS01725
uniprot id: A0A0B6F1K4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

161899:CSING RS05340
gene id: 161899:CSING_RS05340
uniprot id: A0A0B6EQ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

161899:CSING RS08830
gene id: 161899:CSING_RS08830
uniprot id: A0A0B6F5L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

161899:CSING RS00420
gene id: 161899:CSING_RS00420
uniprot id: A0A0B6EXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

161899:CSING RS02855
gene id: 161899:CSING_RS02855
uniprot id: A0A0B6F297
names: Similarity
messages: Belongs to the peptidase C40 family.

161899:CSING RS04935
gene id: 161899:CSING_RS04935
uniprot id: A0A0B6F3G5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS07250
gene id: 161899:CSING_RS07250
uniprot id: A0A0B6F4R6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

161899:CSING RS02165
gene id: 161899:CSING_RS02165
uniprot id: A0A0B6EYJ9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

161899:CSING RS02225
gene id: 161899:CSING_RS02225
uniprot id: A0A0B6F1X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

161899:CSING RS10080
gene id: 161899:CSING_RS10080
uniprot id: A0A0B6F365
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

161899:CSING RS10525
gene id: 161899:CSING_RS10525
uniprot id: A0A0B6F5J4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

161899:CSING RS07070
gene id: 161899:CSING_RS07070
uniprot id: A0A0B6ER38
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

161899:CSING RS10760
gene id: 161899:CSING_RS10760
uniprot id: A0A0B6EY30
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

161899:CSING RS08325
gene id: 161899:CSING_RS08325
uniprot id: A0A0B6F202
names: Similarity
messages: Belongs to the UPF0102 family.

161899:CSING RS05660
gene id: 161899:CSING_RS05660
uniprot id: A0A0B6EV51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

161899:CSING RS09635
gene id: 161899:CSING_RS09635
uniprot id: A0A0B6F630
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

161899:CSING RS00940
gene id: 161899:CSING_RS00940
uniprot id: A0A0B6ESJ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

161899:CSING RS05620
gene id: 161899:CSING_RS05620
uniprot id: A0A0B6F2M9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

161899:CSING RS02780
gene id: 161899:CSING_RS02780
uniprot id: A0A0B6F289
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

161899:CSING RS10210
gene id: 161899:CSING_RS10210
uniprot id: A0A0B6F6I3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

161899:CSING RS02445
gene id: 161899:CSING_RS02445
uniprot id: A0A0B6ENJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

161899:CSING RS09175
gene id: 161899:CSING_RS09175
uniprot id: A0A0B6ES87
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS04735
gene id: 161899:CSING_RS04735
uniprot id: A0A0B6F3B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

161899:CSING RS11920
gene id: 161899:CSING_RS11920
uniprot id: A0A0B6ETW2
names: Subcellular Location Annotation
messages: Membrane

161899:CSING RS08585
gene id: 161899:CSING_RS08585
uniprot id: A0A0B6F5H4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

161899:CSING RS08740
gene id: 161899:CSING_RS08740
uniprot id: A0A0B6ES00
names: Similarity
messages: Belongs to the asparaginase 1 family.

161899:CSING RS02010
gene id: 161899:CSING_RS02010
uniprot id: A0A0B6EYG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

161899:CSING RS08285
gene id: 161899:CSING_RS08285
uniprot id: A0A0B6F5B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

161899:CSING RS02140
gene id: 161899:CSING_RS02140
uniprot id: A0A0B6EYJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

161899:CSING RS10315
gene id: 161899:CSING_RS10315
uniprot id: A0A0B6F6K1
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

161899:CSING RS10545
gene id: 161899:CSING_RS10545
uniprot id: A0A0B6EXZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

161899:CSING RS00345
gene id: 161899:CSING_RS00345
uniprot id: A0A0B6EXI1
names: Similarity
messages: Belongs to the LOG family.

161899:CSING RS06280
gene id: 161899:CSING_RS06280
uniprot id: A0A0B6F462
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

161899:CSING RS07805
gene id: 161899:CSING_RS07805
uniprot id: A0A0B6F1T0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

161899:CSING RS12870
gene id: 161899:CSING_RS12870
uniprot id: A0A0B6EUJ4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

161899:CSING RS07305
gene id: 161899:CSING_RS07305
uniprot id: A0A0B6ER98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

161899:CSING RS11880
gene id: 161899:CSING_RS11880
uniprot id: A0A0B6F661
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

161899:CSING RS01850
gene id: 161899:CSING_RS01850
uniprot id: A0A0B6EN37
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

161899:CSING RS03400
gene id: 161899:CSING_RS03400
uniprot id: A0A0B6EP17
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

161899:CSING RS04875
gene id: 161899:CSING_RS04875
uniprot id: A0A0B6F034
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

161899:CSING RS01720
gene id: 161899:CSING_RS01720
uniprot id: A0A0B6F0C8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.