1577791:Mpt1 RS03890
gene id: 1577791:Mpt1_RS03890
uniprot id: A0A0A7LBY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1577791:Mpt1 RS05980
gene id: 1577791:Mpt1_RS05980
uniprot id: A0A0A7LD44
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

1577791:Mpt1 RS02025
gene id: 1577791:Mpt1_RS02025
uniprot id: A0A0A7LBB4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1577791:Mpt1 RS01770
gene id: 1577791:Mpt1_RS01770
uniprot id: A0A0A7LAR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1577791:Mpt1 RS02375
gene id: 1577791:Mpt1_RS02375
uniprot id: A0A0A7LDH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1577791:Mpt1 RS00150
gene id: 1577791:Mpt1_RS00150
uniprot id: A0A0A7LC85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1577791:Mpt1 RS04660
gene id: 1577791:Mpt1_RS04660
uniprot id: A0A0A7LCM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS04060
gene id: 1577791:Mpt1_RS04060
uniprot id: A0A0A7LGS7
names: Similarity
messages: Belongs to the UPF0210 family.

1577791:Mpt1 RS06225
gene id: 1577791:Mpt1_RS06225
uniprot id: A0A0A7LDA7
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05270
gene id: 1577791:Mpt1_RS05270
uniprot id: A0A0A7LCY5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS06860
gene id: 1577791:Mpt1_RS06860
uniprot id: A0A0A7LE34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS00265
gene id: 1577791:Mpt1_RS00265
uniprot id: A0A0A7LA52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1577791:Mpt1 RS02470
gene id: 1577791:Mpt1_RS02470
uniprot id: A0A0A7LFV8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1577791:Mpt1 RS05025
gene id: 1577791:Mpt1_RS05025
uniprot id: A0A0A7LCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1577791:Mpt1 RS00155
gene id: 1577791:Mpt1_RS00155
uniprot id: A0A0A7LA88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS01010
gene id: 1577791:Mpt1_RS01010
uniprot id: A0A0A7LF46
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1577791:Mpt1 RS00210
gene id: 1577791:Mpt1_RS00210
uniprot id: A0A0A7LA40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1577791:Mpt1 RS00250
gene id: 1577791:Mpt1_RS00250
uniprot id: A0A0A7LEK2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS02360
gene id: 1577791:Mpt1_RS02360
uniprot id: A0A0A7LBC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS03770
gene id: 1577791:Mpt1_RS03770
uniprot id: A0A0A7LED1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1577791:Mpt1 RS02900
gene id: 1577791:Mpt1_RS02900
uniprot id: A0A0A7LDT5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03000
gene id: 1577791:Mpt1_RS03000
uniprot id: A0A0A7LBG5
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

1577791:Mpt1 RS00320
gene id: 1577791:Mpt1_RS00320
uniprot id: A0A0A7LA65
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

1577791:Mpt1 RS07160
gene id: 1577791:Mpt1_RS07160
uniprot id: A0A0A7LDP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1577791:Mpt1 RS01730
gene id: 1577791:Mpt1_RS01730
uniprot id: A0A0A7LAQ4
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS04325
gene id: 1577791:Mpt1_RS04325
uniprot id: A0A0A7LEK8
names: Similarity
messages: Belongs to the FrhG family.

1577791:Mpt1 RS00035
gene id: 1577791:Mpt1_RS00035
uniprot id: A0A0A7LA66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1577791:Mpt1 RS00565
gene id: 1577791:Mpt1_RS00565
uniprot id: A0A0A7LES1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1577791:Mpt1 RS06850
gene id: 1577791:Mpt1_RS06850
uniprot id: A0A0A7LIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1577791:Mpt1 RS07100
gene id: 1577791:Mpt1_RS07100
uniprot id: A0A0A7LE69
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

1577791:Mpt1 RS06580
gene id: 1577791:Mpt1_RS06580
uniprot id: A0A0A7LFZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1577791:Mpt1 RS04655
gene id: 1577791:Mpt1_RS04655
uniprot id: A0A0A7LCT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1577791:Mpt1 RS06020
gene id: 1577791:Mpt1_RS06020
uniprot id: A0A0A7LDL6
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1577791:Mpt1 RS05255
gene id: 1577791:Mpt1_RS05255
uniprot id: A0A0A7LHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1577791:Mpt1 RS06815
gene id: 1577791:Mpt1_RS06815
uniprot id: A0A0A7LDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1577791:Mpt1 RS05925
gene id: 1577791:Mpt1_RS05925
uniprot id: A0A0A7LDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1577791:Mpt1 RS00700
gene id: 1577791:Mpt1_RS00700
uniprot id: A0A0A7LAK0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

1577791:Mpt1 RS04620
gene id: 1577791:Mpt1_RS04620
uniprot id: A0A0A7LH17
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1577791:Mpt1 RS01310
gene id: 1577791:Mpt1_RS01310
uniprot id: A0A0A7LAR9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1577791:Mpt1 RS03860
gene id: 1577791:Mpt1_RS03860
uniprot id: A0A0A7LC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1577791:Mpt1 RS00445
gene id: 1577791:Mpt1_RS00445
uniprot id: A0A0A7LAE3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1577791:Mpt1 RS06245
gene id: 1577791:Mpt1_RS06245
uniprot id: A0A0A7LDJ8
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS01375
gene id: 1577791:Mpt1_RS01375
uniprot id: A0A0A7LB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1577791:Mpt1 RS01125
gene id: 1577791:Mpt1_RS01125
uniprot id: A0A0A7LF64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1577791:Mpt1 RS03630
gene id: 1577791:Mpt1_RS03630
uniprot id: A0A0A7LGL5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS06070
gene id: 1577791:Mpt1_RS06070
uniprot id: A0A0A7LDH5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1577791:Mpt1 RS06170
gene id: 1577791:Mpt1_RS06170
uniprot id: A0A0A7LDI8
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1577791:Mpt1 RS05935
gene id: 1577791:Mpt1_RS05935
uniprot id: A0A0A7LD32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1577791:Mpt1 RS04750
gene id: 1577791:Mpt1_RS04750
uniprot id: A0A0A7LH37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS01970
gene id: 1577791:Mpt1_RS01970
uniprot id: A0A0A7LDA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1577791:Mpt1 RS00540
gene id: 1577791:Mpt1_RS00540
uniprot id: A0A0A7LER5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1577791:Mpt1 RS06000
gene id: 1577791:Mpt1_RS06000
uniprot id: A0A0A7LDD6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1577791:Mpt1 RS01330
gene id: 1577791:Mpt1_RS01330
uniprot id: A0A0A7LAS2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1577791:Mpt1 RS04125
gene id: 1577791:Mpt1_RS04125
uniprot id: A0A0A7LEH6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1577791:Mpt1 RS07120
gene id: 1577791:Mpt1_RS07120
uniprot id: A0A0A7LG64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS00835
gene id: 1577791:Mpt1_RS00835
uniprot id: A0A0A7LCQ8
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

1577791:Mpt1 RS05710
gene id: 1577791:Mpt1_RS05710
uniprot id: A0A0A7LCX5
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05645
gene id: 1577791:Mpt1_RS05645
uniprot id: A0A0A7LDC8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1577791:Mpt1 RS01685
gene id: 1577791:Mpt1_RS01685
uniprot id: A0A0A7LFG7
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1577791:Mpt1 RS01320
gene id: 1577791:Mpt1_RS01320
uniprot id: A0A0A7LD09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1577791:Mpt1 RS04715
gene id: 1577791:Mpt1_RS04715
uniprot id: A0A0A7LCN3
names: Similarity
messages: Belongs to the SUI1 family.

1577791:Mpt1 RS04705
gene id: 1577791:Mpt1_RS04705
uniprot id: A0A0A7LES3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS05205
gene id: 1577791:Mpt1_RS05205
uniprot id: A0A0A7LHC6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS06280
gene id: 1577791:Mpt1_RS06280
uniprot id: A0A0A7LI16
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS02040
gene id: 1577791:Mpt1_RS02040
uniprot id: A0A0A7LFN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1577791:Mpt1 RS04480
gene id: 1577791:Mpt1_RS04480
uniprot id: A0A0A7LCQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1577791:Mpt1 RS01700
gene id: 1577791:Mpt1_RS01700
uniprot id: A0A0A7LAY9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1577791:Mpt1 RS06985
gene id: 1577791:Mpt1_RS06985
uniprot id: A0A0A7LID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1577791:Mpt1 RS05660
gene id: 1577791:Mpt1_RS05660
uniprot id: A0A0A7LHL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1577791:Mpt1 RS00675
gene id: 1577791:Mpt1_RS00675
uniprot id: A0A0A7LAJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

1577791:Mpt1 RS01080
gene id: 1577791:Mpt1_RS01080
uniprot id: A0A0A7LCX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1577791:Mpt1 RS03400
gene id: 1577791:Mpt1_RS03400
uniprot id: A0A0A7LC46
names: Function
messages: Part of a potassium transport system.

1577791:Mpt1 RS07075
gene id: 1577791:Mpt1_RS07075
uniprot id: A0A0A7LE66
names: Similarity
messages: Belongs to the class-I fumarase family.

1577791:Mpt1 RS07185
gene id: 1577791:Mpt1_RS07185
uniprot id: A0A0A7LDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1577791:Mpt1 RS02215
gene id: 1577791:Mpt1_RS02215
uniprot id: A0A0A7LB90
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1577791:Mpt1 RS01495
gene id: 1577791:Mpt1_RS01495
uniprot id: A0A0A7LAL9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1577791:Mpt1 RS07090
gene id: 1577791:Mpt1_RS07090
uniprot id: A0A0A7LIF5
names: Similarity
messages: Belongs to the MCM family.

1577791:Mpt1 RS05345
gene id: 1577791:Mpt1_RS05345
uniprot id: A0A0A7LD03
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1577791:Mpt1 RS01175
gene id: 1577791:Mpt1_RS01175
uniprot id: A0A0A7LF73
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1577791:Mpt1 RS02095
gene id: 1577791:Mpt1_RS02095
uniprot id: A0A0A7LDC5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1577791:Mpt1 RS03620
gene id: 1577791:Mpt1_RS03620
uniprot id: A0A0A7LC49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1577791:Mpt1 RS01785
gene id: 1577791:Mpt1_RS01785
uniprot id: A0A0A7LB77
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS00335
gene id: 1577791:Mpt1_RS00335
uniprot id: A0A0A7LEL4
names: Similarity
messages: Belongs to the HupF/HypC family.

1577791:Mpt1 RS00870
gene id: 1577791:Mpt1_RS00870
uniprot id: A0A0A7LAI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1577791:Mpt1 RS02575
gene id: 1577791:Mpt1_RS02575
uniprot id: A0A0A7LFX9
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS03450
gene id: 1577791:Mpt1_RS03450
uniprot id: A0A0A7LC81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1577791:Mpt1 RS05555
gene id: 1577791:Mpt1_RS05555
uniprot id: A0A0A7LCT9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

1577791:Mpt1 RS06175
gene id: 1577791:Mpt1_RS06175
uniprot id: A0A0A7LDA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1577791:Mpt1 RS04130
gene id: 1577791:Mpt1_RS04130
uniprot id: A0A0A7LCJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1577791:Mpt1 RS03820
gene id: 1577791:Mpt1_RS03820
uniprot id: A0A0A7LED8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1577791:Mpt1 RS00365
gene id: 1577791:Mpt1_RS00365
uniprot id: A0A0A7LCD9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1577791:Mpt1 RS01500
gene id: 1577791:Mpt1_RS01500
uniprot id: A0A0A7LFD4
names: Similarity
messages: Belongs to the DEAD box helicase family.

1577791:Mpt1 RS01180
gene id: 1577791:Mpt1_RS01180
uniprot id: A0A0A7LCY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1577791:Mpt1 RS03425
gene id: 1577791:Mpt1_RS03425
uniprot id: A0A0A7LC53
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1577791:Mpt1 RS05945
gene id: 1577791:Mpt1_RS05945
uniprot id: A0A0A7LFM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1577791:Mpt1 RS01050
gene id: 1577791:Mpt1_RS01050
uniprot id: A0A0A7LF53
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1577791:Mpt1 RS06740
gene id: 1577791:Mpt1_RS06740
uniprot id: A0A0A7LE15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

1577791:Mpt1 RS06110
gene id: 1577791:Mpt1_RS06110
uniprot id: A0A0A7LFS9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1577791:Mpt1 RS07175
gene id: 1577791:Mpt1_RS07175
uniprot id: A0A0A7LE80
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS02425
gene id: 1577791:Mpt1_RS02425
uniprot id: A0A0A7LDH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1577791:Mpt1 RS01660
gene id: 1577791:Mpt1_RS01660
uniprot id: A0A0A7LFG0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1577791:Mpt1 RS03330
gene id: 1577791:Mpt1_RS03330
uniprot id: A0A0A7LBX7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1577791:Mpt1 RS05305
gene id: 1577791:Mpt1_RS05305
uniprot id: A0A0A7LHE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1577791:Mpt1 RS06480
gene id: 1577791:Mpt1_RS06480
uniprot id: A0A0A7LFX7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1577791:Mpt1 RS06445
gene id: 1577791:Mpt1_RS06445
uniprot id: A0A0A7LDM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1577791:Mpt1 RS01850
gene id: 1577791:Mpt1_RS01850
uniprot id: A0A0A7LB17
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1577791:Mpt1 RS03490
gene id: 1577791:Mpt1_RS03490
uniprot id: A0A0A7LBT7
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1577791:Mpt1 RS03170
gene id: 1577791:Mpt1_RS03170
uniprot id: A0A0A7LE00
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1577791:Mpt1 RS00630
gene id: 1577791:Mpt1_RS00630
uniprot id: A0A0A7LAC9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1577791:Mpt1 RS04820
gene id: 1577791:Mpt1_RS04820
uniprot id: A0A0A7LH50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1577791:Mpt1 RS02955
gene id: 1577791:Mpt1_RS02955
uniprot id: A0A0A7LG59
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1577791:Mpt1 RS05565
gene id: 1577791:Mpt1_RS05565
uniprot id: A0A0A7LFB1
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1577791:Mpt1 RS00795
gene id: 1577791:Mpt1_RS00795
uniprot id: A0A0A7LAG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS06575
gene id: 1577791:Mpt1_RS06575
uniprot id: A0A0A7LI65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1577791:Mpt1 RS00785
gene id: 1577791:Mpt1_RS00785
uniprot id: A0A0A7LCP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1577791:Mpt1 RS01135
gene id: 1577791:Mpt1_RS01135
uniprot id: A0A0A7LAW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1577791:Mpt1 RS00215
gene id: 1577791:Mpt1_RS00215
uniprot id: A0A0A7L9X0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1577791:Mpt1 RS06515
gene id: 1577791:Mpt1_RS06515
uniprot id: A0A0A7LDN5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1577791:Mpt1 RS02010
gene id: 1577791:Mpt1_RS02010
uniprot id: A0A0A7LAV5
names: Similarity
messages: Belongs to the HypD family.

1577791:Mpt1 RS04720
gene id: 1577791:Mpt1_RS04720
uniprot id: A0A0A7LCA9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1577791:Mpt1 RS03420
gene id: 1577791:Mpt1_RS03420
uniprot id: A0A0A7LE62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1577791:Mpt1 RS02050
gene id: 1577791:Mpt1_RS02050
uniprot id: A0A0A7LBB9
names: Similarity
messages: Belongs to the peptidase M18 family.

1577791:Mpt1 RS00145
gene id: 1577791:Mpt1_RS00145
uniprot id: A0A0A7LEI0
names: Function
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

1577791:Mpt1 RS05860
gene id: 1577791:Mpt1_RS05860
uniprot id: A0A0A7LD11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1577791:Mpt1 RS07300
gene id: 1577791:Mpt1_RS07300
uniprot id: A0A0A7LEM3
names: Similarity
messages: Belongs to the Fur family.

1577791:Mpt1 RS05650
gene id: 1577791:Mpt1_RS05650
uniprot id: A0A0A7LD58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1577791:Mpt1 RS04395
gene id: 1577791:Mpt1_RS04395
uniprot id: A0A0A7LGY0
names: Similarity
messages: Belongs to the PdaD family.

1577791:Mpt1 RS06585
gene id: 1577791:Mpt1_RS06585
uniprot id: A0A0A7LDZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1577791:Mpt1 RS05285
gene id: 1577791:Mpt1_RS05285
uniprot id: A0A0A7LF38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1577791:Mpt1 RS01190
gene id: 1577791:Mpt1_RS01190
uniprot id: A0A0A7LAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1577791:Mpt1 RS01115
gene id: 1577791:Mpt1_RS01115
uniprot id: A0A0A7LAP5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

1577791:Mpt1 RS02650
gene id: 1577791:Mpt1_RS02650
uniprot id: A0A0A7LDM3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1577791:Mpt1 RS03430
gene id: 1577791:Mpt1_RS03430
uniprot id: A0A0A7LC19
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

1577791:Mpt1 RS05020
gene id: 1577791:Mpt1_RS05020
uniprot id: A0A0A7LD02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS00830
gene id: 1577791:Mpt1_RS00830
uniprot id: A0A0A7LEX9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1577791:Mpt1 RS02455
gene id: 1577791:Mpt1_RS02455
uniprot id: A0A0A7LBJ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1577791:Mpt1 RS05720
gene id: 1577791:Mpt1_RS05720
uniprot id: A0A0A7LFF8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1577791:Mpt1 RS07195
gene id: 1577791:Mpt1_RS07195
uniprot id: A0A0A7LG79
names: Similarity
messages: Belongs to the peptidase M20A family.

1577791:Mpt1 RS04085
gene id: 1577791:Mpt1_RS04085
uniprot id: A0A0A7LC08
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1577791:Mpt1 RS04735
gene id: 1577791:Mpt1_RS04735
uniprot id: A0A0A7LCU6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1577791:Mpt1 RS06075
gene id: 1577791:Mpt1_RS06075
uniprot id: A0A0A7LD87
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1577791:Mpt1 RS04650
gene id: 1577791:Mpt1_RS04650
uniprot id: A0A0A7LER1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1577791:Mpt1 RS00475
gene id: 1577791:Mpt1_RS00475
uniprot id: A0A0A7LA98
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS04755
gene id: 1577791:Mpt1_RS04755
uniprot id: A0A0A7LET2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1577791:Mpt1 RS04555
gene id: 1577791:Mpt1_RS04555
uniprot id: A0A0A7LCR7
names: Similarity
messages: Belongs to the UMP kinase family.

1577791:Mpt1 RS06520
gene id: 1577791:Mpt1_RS06520
uniprot id: A0A0A7LDE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS04165
gene id: 1577791:Mpt1_RS04165
uniprot id: A0A0A7LC18
names: Similarity
messages: Belongs to the arsA ATPase family.

1577791:Mpt1 RS06090
gene id: 1577791:Mpt1_RS06090
uniprot id: A0A0A7LDR2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1577791:Mpt1 RS01205
gene id: 1577791:Mpt1_RS01205
uniprot id: A0A0A7LCZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1577791:Mpt1 RS04495
gene id: 1577791:Mpt1_RS04495
uniprot id: A0A0A7LC66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1577791:Mpt1 RS01405
gene id: 1577791:Mpt1_RS01405
uniprot id: A0A0A7LAT5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1577791:Mpt1 RS02345
gene id: 1577791:Mpt1_RS02345
uniprot id: A0A0A7LFT1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1577791:Mpt1 RS06795
gene id: 1577791:Mpt1_RS06795
uniprot id: A0A0A7LDI5
names: Similarity
messages: Belongs to the GARS family.

1577791:Mpt1 RS06550
gene id: 1577791:Mpt1_RS06550
uniprot id: A0A0A7LI61
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1577791:Mpt1 RS03895
gene id: 1577791:Mpt1_RS03895
uniprot id: A0A0A7LGQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS05390
gene id: 1577791:Mpt1_RS05390
uniprot id: A0A0A7LF63
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1577791:Mpt1 RS01285
gene id: 1577791:Mpt1_RS01285
uniprot id: A0A0A7LAZ0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS02610
gene id: 1577791:Mpt1_RS02610
uniprot id: A0A0A7LDL4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1577791:Mpt1 RS07070
gene id: 1577791:Mpt1_RS07070
uniprot id: A0A0A7LG57
names: Similarity
messages: Belongs to the class-I fumarase family.

1577791:Mpt1 RS05245
gene id: 1577791:Mpt1_RS05245
uniprot id: A0A0A7LCX9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1577791:Mpt1 RS04700
gene id: 1577791:Mpt1_RS04700
uniprot id: A0A0A7LH28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1577791:Mpt1 RS05410
gene id: 1577791:Mpt1_RS05410
uniprot id: A0A0A7LHG8
names: Subcellular Location Annotation
messages: Cell membrane

1577791:Mpt1 RS04645
gene id: 1577791:Mpt1_RS04645
uniprot id: A0A0A7LH23
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS03060
gene id: 1577791:Mpt1_RS03060
uniprot id: A0A0A7LG83
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

1577791:Mpt1 RS00305
gene id: 1577791:Mpt1_RS00305
uniprot id: A0A0A7LEL2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1577791:Mpt1 RS05280
gene id: 1577791:Mpt1_RS05280
uniprot id: A0A0A7LHE3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1577791:Mpt1 RS04220
gene id: 1577791:Mpt1_RS04220
uniprot id: A0A0A7LGU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS03985
gene id: 1577791:Mpt1_RS03985
uniprot id: A0A0A7LCH2
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1577791:Mpt1 RS03165
gene id: 1577791:Mpt1_RS03165
uniprot id: A0A0A7LGA3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1577791:Mpt1 RS00340
gene id: 1577791:Mpt1_RS00340
uniprot id: A0A0A7LCD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1577791:Mpt1 RS01480
gene id: 1577791:Mpt1_RS01480
uniprot id: A0A0A7LD30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

1577791:Mpt1 RS05605
gene id: 1577791:Mpt1_RS05605
uniprot id: A0A0A7LCU9
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1577791:Mpt1 RS07180
gene id: 1577791:Mpt1_RS07180
uniprot id: A0A0A7LE06
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1577791:Mpt1 RS01400
gene id: 1577791:Mpt1_RS01400
uniprot id: A0A0A7LB11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1577791:Mpt1 RS00465
gene id: 1577791:Mpt1_RS00465
uniprot id: A0A0A7LCG9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1577791:Mpt1 RS06050
gene id: 1577791:Mpt1_RS06050
uniprot id: A0A0A7LDG8
names: Similarity
messages: Belongs to the UPF0201 family.

1577791:Mpt1 RS01940
gene id: 1577791:Mpt1_RS01940
uniprot id: A0A0A7LFL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1577791:Mpt1 RS02590
gene id: 1577791:Mpt1_RS02590
uniprot id: A0A0A7LBL9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1577791:Mpt1 RS07785
gene id: 1577791:Mpt1_RS07785
uniprot id: A0A0A7LEQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1577791:Mpt1 RS07220
gene id: 1577791:Mpt1_RS07220
uniprot id: A0A0A7LD42
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1577791:Mpt1 RS00765
gene id: 1577791:Mpt1_RS00765
uniprot id: A0A0A7LA95
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1577791:Mpt1 RS04915
gene id: 1577791:Mpt1_RS04915
uniprot id: A0A0A7LCG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1577791:Mpt1 RS03970
gene id: 1577791:Mpt1_RS03970
uniprot id: A0A0A7LBZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1577791:Mpt1 RS03885
gene id: 1577791:Mpt1_RS03885
uniprot id: A0A0A7LC77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1577791:Mpt1 RS06460
gene id: 1577791:Mpt1_RS06460
uniprot id: A0A0A7LDX0
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

1577791:Mpt1 RS04860
gene id: 1577791:Mpt1_RS04860
uniprot id: A0A0A7LCX0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS05200
gene id: 1577791:Mpt1_RS05200
uniprot id: A0A0A7LCL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1577791:Mpt1 RS04865
gene id: 1577791:Mpt1_RS04865
uniprot id: A0A0A7LCR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1577791:Mpt1 RS01900
gene id: 1577791:Mpt1_RS01900
uniprot id: A0A0A7LB92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1577791:Mpt1 RS01280
gene id: 1577791:Mpt1_RS01280
uniprot id: A0A0A7LD01
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1577791:Mpt1 RS05635
gene id: 1577791:Mpt1_RS05635
uniprot id: A0A0A7LHL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1577791:Mpt1 RS04635
gene id: 1577791:Mpt1_RS04635
uniprot id: A0A0A7LCL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1577791:Mpt1 RS02835
gene id: 1577791:Mpt1_RS02835
uniprot id: A0A0A7LBM0
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05150
gene id: 1577791:Mpt1_RS05150
uniprot id: A0A0A7LF09
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1577791:Mpt1 RS05960
gene id: 1577791:Mpt1_RS05960
uniprot id: A0A0A7LD38
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS02505
gene id: 1577791:Mpt1_RS02505
uniprot id: A0A0A7LDJ3
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS02350
gene id: 1577791:Mpt1_RS02350
uniprot id: A0A0A7LDG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1577791:Mpt1 RS00665
gene id: 1577791:Mpt1_RS00665
uniprot id: A0A0A7LEU8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS05595
gene id: 1577791:Mpt1_RS05595
uniprot id: A0A0A7LDB6
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS00495
gene id: 1577791:Mpt1_RS00495
uniprot id: A0A0A7LAF5
names: Similarity
messages: Belongs to the archease family.

1577791:Mpt1 RS02035
gene id: 1577791:Mpt1_RS02035
uniprot id: A0A0A7LAV9
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS04670
gene id: 1577791:Mpt1_RS04670
uniprot id: A0A0A7LH25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1577791:Mpt1 RS06600
gene id: 1577791:Mpt1_RS06600
uniprot id: A0A0A7LI70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1577791:Mpt1 RS06855
gene id: 1577791:Mpt1_RS06855
uniprot id: A0A0A7LG25
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1577791:Mpt1 RS06595
gene id: 1577791:Mpt1_RS06595
uniprot id: A0A0A7LDF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1577791:Mpt1 RS04675
gene id: 1577791:Mpt1_RS04675
uniprot id: A0A0A7LER7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS02930
gene id: 1577791:Mpt1_RS02930
uniprot id: A0A0A7LDU0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1577791:Mpt1 RS00080
gene id: 1577791:Mpt1_RS00080
uniprot id: A0A0A7LA72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1577791:Mpt1 RS04685
gene id: 1577791:Mpt1_RS04685
uniprot id: A0A0A7LCT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1577791:Mpt1 RS05770
gene id: 1577791:Mpt1_RS05770
uniprot id: A0A0A7LHP2
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS01950
gene id: 1577791:Mpt1_RS01950
uniprot id: A0A0A7LBA2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1577791:Mpt1 RS04550
gene id: 1577791:Mpt1_RS04550
uniprot id: A0A0A7LEP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1577791:Mpt1 RS04570
gene id: 1577791:Mpt1_RS04570
uniprot id: A0A0A7LH09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1577791:Mpt1 RS06220
gene id: 1577791:Mpt1_RS06220
uniprot id: A0A0A7LDJ4
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS03645
gene id: 1577791:Mpt1_RS03645
uniprot id: A0A0A7LC52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS04995
gene id: 1577791:Mpt1_RS04995
uniprot id: A0A0A7LCZ6
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

1577791:Mpt1 RS01325
gene id: 1577791:Mpt1_RS01325
uniprot id: A0A0A7LAZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1577791:Mpt1 RS06820
gene id: 1577791:Mpt1_RS06820
uniprot id: A0A0A7LDI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1577791:Mpt1 RS02155
gene id: 1577791:Mpt1_RS02155
uniprot id: A0A0A7LBD6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1577791:Mpt1 RS04360
gene id: 1577791:Mpt1_RS04360
uniprot id: A0A0A7LCG6
names: Similarity
messages: Belongs to the HdrB family.

1577791:Mpt1 RS04695
gene id: 1577791:Mpt1_RS04695
uniprot id: A0A0A7LCA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS01270
gene id: 1577791:Mpt1_RS01270
uniprot id: A0A0A7LAJ2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1577791:Mpt1 RS05955
gene id: 1577791:Mpt1_RS05955
uniprot id: A0A0A7LDC3
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05115
gene id: 1577791:Mpt1_RS05115
uniprot id: A0A0A7LHA9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1577791:Mpt1 RS00425
gene id: 1577791:Mpt1_RS00425
uniprot id: A0A0A7LA86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1577791:Mpt1 RS07535
gene id: 1577791:Mpt1_RS07535
uniprot id: A0A0A7LFD9
names: Function
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

1577791:Mpt1 RS01420
gene id: 1577791:Mpt1_RS01420
uniprot id: A0A0A7LD23
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1577791:Mpt1 RS00455
gene id: 1577791:Mpt1_RS00455
uniprot id: A0A0A7LA18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1577791:Mpt1 RS00535
gene id: 1577791:Mpt1_RS00535
uniprot id: A0A0A7LA36
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1577791:Mpt1 RS06335
gene id: 1577791:Mpt1_RS06335
uniprot id: A0A0A7LFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1577791:Mpt1 RS01905
gene id: 1577791:Mpt1_RS01905
uniprot id: A0A0A7LB27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1577791:Mpt1 RS03865
gene id: 1577791:Mpt1_RS03865
uniprot id: A0A0A7LBY2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1577791:Mpt1 RS01025
gene id: 1577791:Mpt1_RS01025
uniprot id: A0A0A7LAN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS00220
gene id: 1577791:Mpt1_RS00220
uniprot id: A0A0A7LEJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS05540
gene id: 1577791:Mpt1_RS05540
uniprot id: A0A0A7LFA2
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.

1577791:Mpt1 RS03140
gene id: 1577791:Mpt1_RS03140
uniprot id: A0A0A7LG97
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS03920
gene id: 1577791:Mpt1_RS03920
uniprot id: A0A0A7LGQ7
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS07290
gene id: 1577791:Mpt1_RS07290
uniprot id: A0A0A7LGM2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1577791:Mpt1 RS03245
gene id: 1577791:Mpt1_RS03245
uniprot id: A0A0A7LC11
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1577791:Mpt1 RS01475
gene id: 1577791:Mpt1_RS01475
uniprot id: A0A0A7LFC9
names: Similarity
messages: Belongs to the HdrB family.

1577791:Mpt1 RS00805
gene id: 1577791:Mpt1_RS00805
uniprot id: A0A0A7LEX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1577791:Mpt1 RS03540
gene id: 1577791:Mpt1_RS03540
uniprot id: A0A0A7LCA8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1577791:Mpt1 RS00995
gene id: 1577791:Mpt1_RS00995
uniprot id: A0A0A7LAU1
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1577791:Mpt1 RS01145
gene id: 1577791:Mpt1_RS01145
uniprot id: A0A0A7LAH7
names: Similarity
messages: Belongs to the UPF0284 family.

1577791:Mpt1 RS02355
gene id: 1577791:Mpt1_RS02355
uniprot id: A0A0A7LBH1
names: Similarity
messages: Belongs to the PDCD5 family.

1577791:Mpt1 RS05250
gene id: 1577791:Mpt1_RS05250
uniprot id: A0A0A7LCN0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1577791:Mpt1 RS05260
gene id: 1577791:Mpt1_RS05260
uniprot id: A0A0A7LF32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1577791:Mpt1 RS00490
gene id: 1577791:Mpt1_RS00490
uniprot id: A0A0A7LCH7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

1577791:Mpt1 RS04145
gene id: 1577791:Mpt1_RS04145
uniprot id: A0A0A7LGT8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS00790
gene id: 1577791:Mpt1_RS00790
uniprot id: A0A0A7LAL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1577791:Mpt1 RS03235
gene id: 1577791:Mpt1_RS03235
uniprot id: A0A0A7LGC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1577791:Mpt1 RS05230
gene id: 1577791:Mpt1_RS05230
uniprot id: A0A0A7LHD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1577791:Mpt1 RS00195
gene id: 1577791:Mpt1_RS00195
uniprot id: A0A0A7LEJ2
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1577791:Mpt1 RS03595
gene id: 1577791:Mpt1_RS03595
uniprot id: A0A0A7LC47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1577791:Mpt1 RS00800
gene id: 1577791:Mpt1_RS00800
uniprot id: A0A0A7LAA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS04815
gene id: 1577791:Mpt1_RS04815
uniprot id: A0A0A7LCD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1577791:Mpt1 RS01595
gene id: 1577791:Mpt1_RS01595
uniprot id: A0A0A7LAN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1577791:Mpt1 RS03160
gene id: 1577791:Mpt1_RS03160
uniprot id: A0A0A7LBJ7
names: Similarity
messages: Belongs to the pirin family.

1577791:Mpt1 RS05805
gene id: 1577791:Mpt1_RS05805
uniprot id: A0A0A7LDG1
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS03350
gene id: 1577791:Mpt1_RS03350
uniprot id: A0A0A7LC32
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1577791:Mpt1 RS01575
gene id: 1577791:Mpt1_RS01575
uniprot id: A0A0A7LFE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1577791:Mpt1 RS06470
gene id: 1577791:Mpt1_RS06470
uniprot id: A0A0A7LDE0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1577791:Mpt1 RS00945
gene id: 1577791:Mpt1_RS00945
uniprot id: A0A0A7LAM2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1577791:Mpt1 RS00315
gene id: 1577791:Mpt1_RS00315
uniprot id: A0A0A7LAC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS05900
gene id: 1577791:Mpt1_RS05900
uniprot id: A0A0A7LDI3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1577791:Mpt1 RS03765
gene id: 1577791:Mpt1_RS03765
uniprot id: A0A0A7LGN2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1577791:Mpt1 RS01185
gene id: 1577791:Mpt1_RS01185
uniprot id: A0A0A7LAX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1577791:Mpt1 RS04640
gene id: 1577791:Mpt1_RS04640
uniprot id: A0A0A7LC94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS06785
gene id: 1577791:Mpt1_RS06785
uniprot id: A0A0A7LE23
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1577791:Mpt1 RS00530
gene id: 1577791:Mpt1_RS00530
uniprot id: A0A0A7LAA9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1577791:Mpt1 RS01120
gene id: 1577791:Mpt1_RS01120
uniprot id: A0A0A7LAH5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1577791:Mpt1 RS01820
gene id: 1577791:Mpt1_RS01820
uniprot id: A0A0A7LB81
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1577791:Mpt1 RS00550
gene id: 1577791:Mpt1_RS00550
uniprot id: A0A0A7LAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1577791:Mpt1 RS03850
gene id: 1577791:Mpt1_RS03850
uniprot id: A0A0A7LEE2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1577791:Mpt1 RS05330
gene id: 1577791:Mpt1_RS05330
uniprot id: A0A0A7LHF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1577791:Mpt1 RS05910
gene id: 1577791:Mpt1_RS05910
uniprot id: A0A0A7LD24
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1577791:Mpt1 RS00650
gene id: 1577791:Mpt1_RS00650
uniprot id: A0A0A7LAJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1577791:Mpt1 RS02005
gene id: 1577791:Mpt1_RS02005
uniprot id: A0A0A7LB49
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1577791:Mpt1 RS06955
gene id: 1577791:Mpt1_RS06955
uniprot id: A0A0A7LDK8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1577791:Mpt1 RS05110
gene id: 1577791:Mpt1_RS05110
uniprot id: A0A0A7LCK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1577791:Mpt1 RS06610
gene id: 1577791:Mpt1_RS06610
uniprot id: A0A0A7LDZ5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1577791:Mpt1 RS00400
gene id: 1577791:Mpt1_RS00400
uniprot id: A0A0A7LA80
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1577791:Mpt1 RS00515
gene id: 1577791:Mpt1_RS00515
uniprot id: A0A0A7LEQ8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1577791:Mpt1 RS06060
gene id: 1577791:Mpt1_RS06060
uniprot id: A0A0A7LHY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1577791:Mpt1 RS06780
gene id: 1577791:Mpt1_RS06780
uniprot id: A0A0A7LG14
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1577791:Mpt1 RS07015
gene id: 1577791:Mpt1_RS07015
uniprot id: A0A0A7LG49
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1577791:Mpt1 RS05665
gene id: 1577791:Mpt1_RS05665
uniprot id: A0A0A7LFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1577791:Mpt1 RS03475
gene id: 1577791:Mpt1_RS03475
uniprot id: A0A0A7LCA0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1577791:Mpt1 RS01845
gene id: 1577791:Mpt1_RS01845
uniprot id: A0A0A7LB85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1577791:Mpt1 RS05930
gene id: 1577791:Mpt1_RS05930
uniprot id: A0A0A7LDB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1577791:Mpt1 RS03085
gene id: 1577791:Mpt1_RS03085
uniprot id: A0A0A7LG88
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03195
gene id: 1577791:Mpt1_RS03195
uniprot id: A0A0A7LE05
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1577791:Mpt1 RS02860
gene id: 1577791:Mpt1_RS02860
uniprot id: A0A0A7LBM4
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05970
gene id: 1577791:Mpt1_RS05970
uniprot id: A0A0A7LDK3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1577791:Mpt1 RS00130
gene id: 1577791:Mpt1_RS00130
uniprot id: A0A0A7LA83
names: Similarity
messages: Belongs to the glutamine synthetase family.

1577791:Mpt1 RS01835
gene id: 1577791:Mpt1_RS01835
uniprot id: A0A0A7LFJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1577791:Mpt1 RS04545
gene id: 1577791:Mpt1_RS04545
uniprot id: A0A0A7LH04
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS01705
gene id: 1577791:Mpt1_RS01705
uniprot id: A0A0A7LAQ0
names: Similarity
messages: Belongs to the RutC family.

1577791:Mpt1 RS06870
gene id: 1577791:Mpt1_RS06870
uniprot id: A0A0A7LDJ5
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.

1577791:Mpt1 RS04855
gene id: 1577791:Mpt1_RS04855
uniprot id: A0A0A7LEV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS02250
gene id: 1577791:Mpt1_RS02250
uniprot id: A0A0A7LDE9
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS02905
gene id: 1577791:Mpt1_RS02905
uniprot id: A0A0A7LBT5
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1577791:Mpt1 RS03560
gene id: 1577791:Mpt1_RS03560
uniprot id: A0A0A7LEA5
names: Similarity
messages: Belongs to the SHMT family.

1577791:Mpt1 RS05295
gene id: 1577791:Mpt1_RS05295
uniprot id: A0A0A7LCZ0
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS01390
gene id: 1577791:Mpt1_RS01390
uniprot id: A0A0A7LFB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1577791:Mpt1 RS03680
gene id: 1577791:Mpt1_RS03680
uniprot id: A0A0A7LBW2
names: Similarity
messages: Belongs to the HsdR family.

1577791:Mpt1 RS06065
gene id: 1577791:Mpt1_RS06065
uniprot id: A0A0A7LDQ8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1577791:Mpt1 RS05825
gene id: 1577791:Mpt1_RS05825
uniprot id: A0A0A7LFI7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1577791:Mpt1 RS00420
gene id: 1577791:Mpt1_RS00420
uniprot id: A0A0A7LAD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1577791:Mpt1 RS00385
gene id: 1577791:Mpt1_RS00385
uniprot id: A0A0A7LEM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS05155
gene id: 1577791:Mpt1_RS05155
uniprot id: A0A0A7LD29
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS04470
gene id: 1577791:Mpt1_RS04470
uniprot id: A0A0A7LGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1577791:Mpt1 RS07200
gene id: 1577791:Mpt1_RS07200
uniprot id: A0A0A7LE84
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1577791:Mpt1 RS01920
gene id: 1577791:Mpt1_RS01920
uniprot id: A0A0A7LD92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1577791:Mpt1 RS01510
gene id: 1577791:Mpt1_RS01510
uniprot id: A0A0A7LB29
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS00875
gene id: 1577791:Mpt1_RS00875
uniprot id: A0A0A7LAB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1577791:Mpt1 RS01600
gene id: 1577791:Mpt1_RS01600
uniprot id: A0A0A7LFF3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1577791:Mpt1 RS06545
gene id: 1577791:Mpt1_RS06545
uniprot id: A0A0A7LDE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1577791:Mpt1 RS00205
gene id: 1577791:Mpt1_RS00205
uniprot id: A0A0A7LA97
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1577791:Mpt1 RS00410
gene id: 1577791:Mpt1_RS00410
uniprot id: A0A0A7LEM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1577791:Mpt1 RS05275
gene id: 1577791:Mpt1_RS05275
uniprot id: A0A0A7LCN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1577791:Mpt1 RS06295
gene id: 1577791:Mpt1_RS06295
uniprot id: A0A0A7LDK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1577791:Mpt1 RS04690
gene id: 1577791:Mpt1_RS04690
uniprot id: A0A0A7LCM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1577791:Mpt1 RS05415
gene id: 1577791:Mpt1_RS05415
uniprot id: A0A0A7LF69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1577791:Mpt1 RS04050
gene id: 1577791:Mpt1_RS04050
uniprot id: A0A0A7LCA1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1577791:Mpt1 RS00860
gene id: 1577791:Mpt1_RS00860
uniprot id: A0A0A7LCR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1577791:Mpt1 RS06945
gene id: 1577791:Mpt1_RS06945
uniprot id: A0A0A7LE46
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1577791:Mpt1 RS06630
gene id: 1577791:Mpt1_RS06630
uniprot id: A0A0A7LI75
names: Similarity
messages: Belongs to the UPF0235 family.

1577791:Mpt1 RS03445
gene id: 1577791:Mpt1_RS03445
uniprot id: A0A0A7LE83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS02295
gene id: 1577791:Mpt1_RS02295
uniprot id: A0A0A7LB15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1577791:Mpt1 RS00270
gene id: 1577791:Mpt1_RS00270
uniprot id: A0A0A7L9Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1577791:Mpt1 RS04845
gene id: 1577791:Mpt1_RS04845
uniprot id: A0A0A7LCE2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1577791:Mpt1 RS00435
gene id: 1577791:Mpt1_RS00435
uniprot id: A0A0A7LEN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1577791:Mpt1 RS01540
gene id: 1577791:Mpt1_RS01540
uniprot id: A0A0A7LAW0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1577791:Mpt1 RS00355
gene id: 1577791:Mpt1_RS00355
uniprot id: A0A0A7L9Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1577791:Mpt1 RS02995
gene id: 1577791:Mpt1_RS02995
uniprot id: A0A0A7LBQ3
names: Similarity
messages: Belongs to the UPF0288 family.

1577791:Mpt1 RS03900
gene id: 1577791:Mpt1_RS03900
uniprot id: A0A0A7LEE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1577791:Mpt1 RS01365
gene id: 1577791:Mpt1_RS01365
uniprot id: A0A0A7LFA9
names: Similarity
messages: Belongs to the UPF0179 family.

1577791:Mpt1 RS00030
gene id: 1577791:Mpt1_RS00030
uniprot id: A0A0A7LC64
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

1577791:Mpt1 RS00285
gene id: 1577791:Mpt1_RS00285
uniprot id: A0A0A7LCB9
names: Similarity
messages: Belongs to the HAM1 NTPase family.

1577791:Mpt1 RS03580
gene id: 1577791:Mpt1_RS03580
uniprot id: A0A0A7LGK8
names: Similarity
messages: Belongs to the DMRL synthase family.

1577791:Mpt1 RS05100
gene id: 1577791:Mpt1_RS05100
uniprot id: A0A0A7LD19
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1577791:Mpt1 RS00970
gene id: 1577791:Mpt1_RS00970
uniprot id: A0A0A7LAT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03785
gene id: 1577791:Mpt1_RS03785
uniprot id: A0A0A7LBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1577791:Mpt1 RS06180
gene id: 1577791:Mpt1_RS06180
uniprot id: A0A0A7LI02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1577791:Mpt1 RS00255
gene id: 1577791:Mpt1_RS00255
uniprot id: A0A0A7LCB0
names: Similarity
messages: Belongs to the TrpC family.

1577791:Mpt1 RS06745
gene id: 1577791:Mpt1_RS06745
uniprot id: A0A0A7LDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1577791:Mpt1 RS05095
gene id: 1577791:Mpt1_RS05095
uniprot id: A0A0A7LEZ8
names: Similarity
messages: Belongs to the GrpE family.

1577791:Mpt1 RS05195
gene id: 1577791:Mpt1_RS05195
uniprot id: A0A0A7LCW6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS00610
gene id: 1577791:Mpt1_RS00610
uniprot id: A0A0A7LET5
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS05080
gene id: 1577791:Mpt1_RS05080
uniprot id: A0A0A7LCU7
names: Subcellular Location Annotation
messages: Membrane

1577791:Mpt1 RS04225
gene id: 1577791:Mpt1_RS04225
uniprot id: A0A0A7LEJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS03585
gene id: 1577791:Mpt1_RS03585
uniprot id: A0A0A7LEB0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1577791:Mpt1 RS01155
gene id: 1577791:Mpt1_RS01155
uniprot id: A0A0A7LCY4
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1577791:Mpt1 RS00260
gene id: 1577791:Mpt1_RS00260
uniprot id: A0A0A7LAA8
names: Similarity
messages: Belongs to the TrpF family.

1577791:Mpt1 RS05705
gene id: 1577791:Mpt1_RS05705
uniprot id: A0A0A7LD66
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1577791:Mpt1 RS06080
gene id: 1577791:Mpt1_RS06080
uniprot id: A0A0A7LHY9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1577791:Mpt1 RS06980
gene id: 1577791:Mpt1_RS06980
uniprot id: A0A0A7LDL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1577791:Mpt1 RS04575
gene id: 1577791:Mpt1_RS04575
uniprot id: A0A0A7LEP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03935
gene id: 1577791:Mpt1_RS03935
uniprot id: A0A0A7LC87
names: Similarity
messages: Belongs to the LarC family.

1577791:Mpt1 RS00900
gene id: 1577791:Mpt1_RS00900
uniprot id: A0A0A7LAD7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS04850
gene id: 1577791:Mpt1_RS04850
uniprot id: A0A0A7LH56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1577791:Mpt1 RS00140
gene id: 1577791:Mpt1_RS00140
uniprot id: A0A0A7L9V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1577791:Mpt1 RS06800
gene id: 1577791:Mpt1_RS06800
uniprot id: A0A0A7LIA5
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS05090
gene id: 1577791:Mpt1_RS05090
uniprot id: A0A0A7LHA4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1577791:Mpt1 RS01455
gene id: 1577791:Mpt1_RS01455
uniprot id: A0A0A7LB21
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

1577791:Mpt1 RS04745
gene id: 1577791:Mpt1_RS04745
uniprot id: A0A0A7LCB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1577791:Mpt1 RS05340
gene id: 1577791:Mpt1_RS05340
uniprot id: A0A0A7LD65
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1577791:Mpt1 RS03295
gene id: 1577791:Mpt1_RS03295
uniprot id: A0A0A7LE31
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS06615
gene id: 1577791:Mpt1_RS06615
uniprot id: A0A0A7LDQ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03735
gene id: 1577791:Mpt1_RS03735
uniprot id: A0A0A7LBW7
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1577791:Mpt1 RS00005
gene id: 1577791:Mpt1_RS00005
uniprot id: A0A0A7LC59
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1577791:Mpt1 RS06010
gene id: 1577791:Mpt1_RS06010
uniprot id: A0A0A7LHV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1577791:Mpt1 RS04920
gene id: 1577791:Mpt1_RS04920
uniprot id: A0A0A7LH71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1577791:Mpt1 RS02450
gene id: 1577791:Mpt1_RS02450
uniprot id: A0A0A7LDI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1577791:Mpt1 RS01910
gene id: 1577791:Mpt1_RS01910
uniprot id: A0A0A7LAT3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1577791:Mpt1 RS03625
gene id: 1577791:Mpt1_RS03625
uniprot id: A0A0A7LBV6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1577791:Mpt1 RS01160
gene id: 1577791:Mpt1_RS01160
uniprot id: A0A0A7LAW9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

1577791:Mpt1 RS00880
gene id: 1577791:Mpt1_RS00880
uniprot id: A0A0A7LEZ5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1577791:Mpt1 RS03485
gene id: 1577791:Mpt1_RS03485
uniprot id: A0A0A7LC33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1577791:Mpt1 RS01585
gene id: 1577791:Mpt1_RS01585
uniprot id: A0A0A7LB41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1577791:Mpt1 RS05600
gene id: 1577791:Mpt1_RS05600
uniprot id: A0A0A7LD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1577791:Mpt1 RS01275
gene id: 1577791:Mpt1_RS01275
uniprot id: A0A0A7LF91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1577791:Mpt1 RS06270
gene id: 1577791:Mpt1_RS06270
uniprot id: A0A0A7LDK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1577791:Mpt1 RS03190
gene id: 1577791:Mpt1_RS03190
uniprot id: A0A0A7LGA9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1577791:Mpt1 RS03915
gene id: 1577791:Mpt1_RS03915
uniprot id: A0A0A7LBZ0
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

1577791:Mpt1 RS04730
gene id: 1577791:Mpt1_RS04730
uniprot id: A0A0A7LES8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1577791:Mpt1 RS01445
gene id: 1577791:Mpt1_RS01445
uniprot id: A0A0A7LD27
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1577791:Mpt1 RS01045
gene id: 1577791:Mpt1_RS01045
uniprot id: A0A0A7LAG4
names: Caution
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03300
gene id: 1577791:Mpt1_RS03300
uniprot id: A0A0A7LC23
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1577791:Mpt1 RS03640
gene id: 1577791:Mpt1_RS03640
uniprot id: A0A0A7LCC3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1577791:Mpt1 RS02420
gene id: 1577791:Mpt1_RS02420
uniprot id: A0A0A7LFU8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1577791:Mpt1 RS02290
gene id: 1577791:Mpt1_RS02290
uniprot id: A0A0A7LBA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1577791:Mpt1 RS05335
gene id: 1577791:Mpt1_RS05335
uniprot id: A0A0A7LF50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1577791:Mpt1 RS06910
gene id: 1577791:Mpt1_RS06910
uniprot id: A0A0A7LIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1577791:Mpt1 RS06085
gene id: 1577791:Mpt1_RS06085
uniprot id: A0A0A7LFS5
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1577791:Mpt1 RS03545
gene id: 1577791:Mpt1_RS03545
uniprot id: A0A0A7LC42
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1577791:Mpt1 RS03535
gene id: 1577791:Mpt1_RS03535
uniprot id: A0A0A7LEA2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1577791:Mpt1 RS04185
gene id: 1577791:Mpt1_RS04185
uniprot id: A0A0A7LCK1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1577791:Mpt1 RS01200
gene id: 1577791:Mpt1_RS01200
uniprot id: A0A0A7LF76
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1577791:Mpt1 RS06565
gene id: 1577791:Mpt1_RS06565
uniprot id: A0A0A7LDP1
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

1577791:Mpt1 RS01630
gene id: 1577791:Mpt1_RS01630
uniprot id: A0A0A7LFF6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1577791:Mpt1 RS04740
gene id: 1577791:Mpt1_RS04740
uniprot id: A0A0A7LCN8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

1577791:Mpt1 RS05640
gene id: 1577791:Mpt1_RS05640
uniprot id: A0A0A7LFD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.