1454006:AW14 RS14000
gene id: 1454006:AW14_RS14000
uniprot id: A0A0C5W045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1454006:AW14 RS06945
gene id: 1454006:AW14_RS06945
uniprot id: A0A0C5W8D5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1454006:AW14 RS07640
gene id: 1454006:AW14_RS07640
uniprot id: A0A0C5WI77
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1454006:AW14 RS05370
gene id: 1454006:AW14_RS05370
uniprot id: A0A0C5W7R4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1454006:AW14 RS13810
gene id: 1454006:AW14_RS13810
uniprot id: A0A0C5WHH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1454006:AW14 RS12905
gene id: 1454006:AW14_RS12905
uniprot id: A0A0C5WH48
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1454006:AW14 RS08320
gene id: 1454006:AW14_RS08320
uniprot id: A0A0C5WBJ7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1454006:AW14 RS01840
gene id: 1454006:AW14_RS01840
uniprot id: A0A0C5WIQ5
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS05905
gene id: 1454006:AW14_RS05905
uniprot id: A0A0C5WKI9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1454006:AW14 RS07380
gene id: 1454006:AW14_RS07380
uniprot id: A0A0C5WAZ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS14115
gene id: 1454006:AW14_RS14115
uniprot id: A0A0C5WEM3
names: Similarity
messages: Belongs to the AIR synthase family.

1454006:AW14 RS07950
gene id: 1454006:AW14_RS07950
uniprot id: A0A0C5WLB3
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1454006:AW14 RS12405
gene id: 1454006:AW14_RS12405
uniprot id: A0A0C5WBA3
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04915
gene id: 1454006:AW14_RS04915
uniprot id: A0A0C5VVE5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1454006:AW14 RS13730
gene id: 1454006:AW14_RS13730
uniprot id: A0A0C5WEE1
names: Similarity
messages: Belongs to the HSP15 family.

1454006:AW14 RS12165
gene id: 1454006:AW14_RS12165
uniprot id: A0A0C5WDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS01830
gene id: 1454006:AW14_RS01830
uniprot id: A0A0C5W618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1454006:AW14 RS11675
gene id: 1454006:AW14_RS11675
uniprot id: A0A0C5WN38
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1454006:AW14 RS02610
gene id: 1454006:AW14_RS02610
uniprot id: A0A0C5W6F1
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04680
gene id: 1454006:AW14_RS04680
uniprot id: A0A0C5WCM1
names: Similarity
messages: Belongs to the RecJ family.

1454006:AW14 RS08005
gene id: 1454006:AW14_RS08005
uniprot id: A0A0C5WLC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1454006:AW14 RS05465
gene id: 1454006:AW14_RS05465
uniprot id: A0A0C5WA78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1454006:AW14 RS05500
gene id: 1454006:AW14_RS05500
uniprot id: A0A0C5WD97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1454006:AW14 RS06165
gene id: 1454006:AW14_RS06165
uniprot id: A0A0C5WDL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP/ATP translocase tlc family.
messages: Membrane

1454006:AW14 RS11780
gene id: 1454006:AW14_RS11780
uniprot id: A0A0C5WN53
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1454006:AW14 RS05470
gene id: 1454006:AW14_RS05470
uniprot id: A0A0C5W7T1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01905
gene id: 1454006:AW14_RS01905
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS04880
gene id: 1454006:AW14_RS04880
uniprot id: A0A0C5WCS8
names: Similarity
messages: Belongs to the YoeB family.

1454006:AW14 RS02355
gene id: 1454006:AW14_RS02355
uniprot id: A0A0C5WBE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1454006:AW14 RS07930
gene id: 1454006:AW14_RS07930
uniprot id: A0A0C5WBA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1454006:AW14 RS05865
gene id: 1454006:AW14_RS05865
uniprot id: A0A0C5W805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1454006:AW14 RS03325
gene id: 1454006:AW14_RS03325
uniprot id: A0A0C5WJC4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1454006:AW14 RS06155
gene id: 1454006:AW14_RS06155
uniprot id: A0A0C5WAJ7
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1454006:AW14 RS11855
gene id: 1454006:AW14_RS11855
uniprot id: A0A0C5WN60
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS11475
gene id: 1454006:AW14_RS11475
uniprot id: A0A0C5WAV8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1454006:AW14 RS00175
gene id: 1454006:AW14_RS00175
uniprot id: A0A0C5VSW5
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1454006:AW14 RS07960
gene id: 1454006:AW14_RS07960
uniprot id: A0A0C5WBB0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS03310
gene id: 1454006:AW14_RS03310
uniprot id: A0A0C5W6Q1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS05590
gene id: 1454006:AW14_RS05590
uniprot id: A0A0C5WDB0
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS07410
gene id: 1454006:AW14_RS07410
uniprot id: A0A0C5W8M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1454006:AW14 RS06080
gene id: 1454006:AW14_RS06080
uniprot id: A0A0C5WDJ8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1454006:AW14 RS02010
gene id: 1454006:AW14_RS02010
uniprot id: A0A0C5WB54
names: Similarity
messages: Belongs to the thioredoxin family.

1454006:AW14 RS01065
gene id: 1454006:AW14_RS01065
uniprot id: A0A0C5W5L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1454006:AW14 RS04855
gene id: 1454006:AW14_RS04855
uniprot id: A0A0C5WK17
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS08010
gene id: 1454006:AW14_RS08010
uniprot id: A0A0C5VWV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1454006:AW14 RS02340
gene id: 1454006:AW14_RS02340
uniprot id: A0A0C5W8T6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1454006:AW14 RS09450
gene id: 1454006:AW14_RS09450
uniprot id: A0A0C5WLZ8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.

1454006:AW14 RS00575
gene id: 1454006:AW14_RS00575
uniprot id: A0A0C5W5E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1454006:AW14 RS05410
gene id: 1454006:AW14_RS05410
uniprot id: A0A0C5VVR7
names: Similarity
messages: Belongs to the Skp family.

1454006:AW14 RS04805
gene id: 1454006:AW14_RS04805
uniprot id: A0A0C5VVC4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS03220
gene id: 1454006:AW14_RS03220
uniprot id: A0A0C5W976
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS07105
gene id: 1454006:AW14_RS07105
uniprot id: A0A0C5WAV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1454006:AW14 RS05815
gene id: 1454006:AW14_RS05815
uniprot id: A0A0C5W800
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1454006:AW14 RS00085
gene id: 1454006:AW14_RS00085
uniprot id: A0A0C5W588
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1454006:AW14 RS11200
gene id: 1454006:AW14_RS11200
uniprot id: A0A0C5VYR4
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1454006:AW14 RS03545
gene id: 1454006:AW14_RS03545
uniprot id: A0A0C5WHY3
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS06875
gene id: 1454006:AW14_RS06875
uniprot id: A0A0C5W8C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1454006:AW14 RS00595
gene id: 1454006:AW14_RS00595
uniprot id: A0A0C5W7Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1454006:AW14 RS05280
gene id: 1454006:AW14_RS05280
uniprot id: A0A0C5WK97
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1454006:AW14 RS02945
gene id: 1454006:AW14_RS02945
uniprot id: A0A0C5WJ88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1454006:AW14 RS05860
gene id: 1454006:AW14_RS05860
uniprot id: A0A0C5WAF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
messages: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
messages: Homotrimer.

1454006:AW14 RS09835
gene id: 1454006:AW14_RS09835
uniprot id: A0A0C5VXT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1454006:AW14 RS11795
gene id: 1454006:AW14_RS11795
uniprot id: A0A0C5WB11
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1454006:AW14 RS08550
gene id: 1454006:AW14_RS08550
uniprot id: A0A0C5WLN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1454006:AW14 RS13505
gene id: 1454006:AW14_RS13505
uniprot id: A0A0C5WNR9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1454006:AW14 RS12490
gene id: 1454006:AW14_RS12490
uniprot id: A0A0C5WND9
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00195
gene id: 1454006:AW14_RS00195
uniprot id: A0A0C5WHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1454006:AW14 RS13715
gene id: 1454006:AW14_RS13715
uniprot id: A0A0C5WNV1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS07900
gene id: 1454006:AW14_RS07900
uniprot id: A0A0C5VWT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS10385
gene id: 1454006:AW14_RS10385
uniprot id: A0A0C5VY44
names: Similarity
messages: Belongs to the group II decarboxylase family.

1454006:AW14 RS01445
gene id: 1454006:AW14_RS01445
uniprot id: A0A0C5WAW1
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1454006:AW14 RS12980
gene id: 1454006:AW14_RS12980
uniprot id: A0A0C5VZJ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS05240
gene id: 1454006:AW14_RS05240
uniprot id: A0A0C5W7P0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1454006:AW14 RS08960
gene id: 1454006:AW14_RS08960
uniprot id: A0A0C5W9H9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS13065
gene id: 1454006:AW14_RS13065
uniprot id: A0A0C5WH75
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS03150
gene id: 1454006:AW14_RS03150
uniprot id: A0A0C5WBT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1454006:AW14 RS11045
gene id: 1454006:AW14_RS11045
uniprot id: A0A0C5WD04
names: Similarity
messages: Belongs to the peptidase S49 family.

1454006:AW14 RS01200
gene id: 1454006:AW14_RS01200
uniprot id: A0A0C5WIE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1454006:AW14 RS02685
gene id: 1454006:AW14_RS02685
uniprot id: A0A0C5W6H2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1454006:AW14 RS01190
gene id: 1454006:AW14_RS01190
uniprot id: A0A0C5W5P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1454006:AW14 RS08640
gene id: 1454006:AW14_RS08640
uniprot id: A0A0C5WLQ0
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS02735
gene id: 1454006:AW14_RS02735
uniprot id: A0A0C5W927
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1454006:AW14 RS02775
gene id: 1454006:AW14_RS02775
uniprot id: A0A0C5WJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

1454006:AW14 RS11235
gene id: 1454006:AW14_RS11235
uniprot id: A0A0C5VYR9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1454006:AW14 RS02995
gene id: 1454006:AW14_RS02995
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS00210
gene id: 1454006:AW14_RS00210
uniprot id: A0A0C5W5A2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1454006:AW14 RS03675
gene id: 1454006:AW14_RS03675
uniprot id: A0A0C5WJG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1454006:AW14 RS05525
gene id: 1454006:AW14_RS05525
uniprot id: A0A0C5W7U3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1454006:AW14 RS09150
gene id: 1454006:AW14_RS09150
uniprot id: A0A0C5WLV7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1454006:AW14 RS01240
gene id: 1454006:AW14_RS01240
uniprot id: A0A0C5VTE7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS12480
gene id: 1454006:AW14_RS12480
uniprot id: A0A0C5WBB8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1454006:AW14 RS05960
gene id: 1454006:AW14_RS05960
uniprot id: A0A0C5VW23
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1454006:AW14 RS05460
gene id: 1454006:AW14_RS05460
uniprot id: A0A0C5VVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1454006:AW14 RS06600
gene id: 1454006:AW14_RS06600
uniprot id: A0A0C5WPJ4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS11850
gene id: 1454006:AW14_RS11850
uniprot id: A0A0C5WGL6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03845
gene id: 1454006:AW14_RS03845
uniprot id: A0A0C5VUV0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1454006:AW14 RS01355
gene id: 1454006:AW14_RS01355
uniprot id: A0A0C5VTG6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS13350
gene id: 1454006:AW14_RS13350
uniprot id: A0A0C5WE62
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS02235
gene id: 1454006:AW14_RS02235
uniprot id: A0A0C5VTY5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1454006:AW14 RS07280
gene id: 1454006:AW14_RS07280
uniprot id: A0A0C5W8J5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS09235
gene id: 1454006:AW14_RS09235
uniprot id: A0A0C5WF27
names: Subcellular Location Annotation
messages: Nucleus

1454006:AW14 RS07215
gene id: 1454006:AW14_RS07215
uniprot id: A0A0C5VWI7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1454006:AW14 RS03835
gene id: 1454006:AW14_RS03835
uniprot id: A0A0C5WC43
names: Similarity
messages: Belongs to the UPF0145 family.

1454006:AW14 RS07970
gene id: 1454006:AW14_RS07970
uniprot id: A0A0C5WEG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1454006:AW14 RS03670
gene id: 1454006:AW14_RS03670
uniprot id: A0A0C5WC10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1454006:AW14 RS13685
gene id: 1454006:AW14_RS13685
uniprot id: A0A0C5WHF5
names: Similarity
messages: Belongs to the UPF0047 family.

1454006:AW14 RS13145
gene id: 1454006:AW14_RS13145
uniprot id: A0A0C5WPV5
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS05365
gene id: 1454006:AW14_RS05365
uniprot id: A0A0C5WA57
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS12425
gene id: 1454006:AW14_RS12425
uniprot id: A0A0C5WDP2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1454006:AW14 RS07255
gene id: 1454006:AW14_RS07255
uniprot id: A0A0C5W8I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1454006:AW14 RS00960
gene id: 1454006:AW14_RS00960
uniprot id: A0A0C5W838
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1454006:AW14 RS01515
gene id: 1454006:AW14_RS01515
uniprot id: A0A0C5VTJ6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1454006:AW14 RS08030
gene id: 1454006:AW14_RS08030
uniprot id: A0A0C5WLC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

1454006:AW14 RS02880
gene id: 1454006:AW14_RS02880
uniprot id: A0A0C5W947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1454006:AW14 RS12765
gene id: 1454006:AW14_RS12765
uniprot id: A0A0C5WDW3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1454006:AW14 RS08530
gene id: 1454006:AW14_RS08530
uniprot id: A0A0C5VX71
names: Similarity
messages: Belongs to the ParB family.

1454006:AW14 RS01350
gene id: 1454006:AW14_RS01350
uniprot id: A0A0C5WIG9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1454006:AW14 RS09305
gene id: 1454006:AW14_RS09305
uniprot id: A0A0C5W9L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1454006:AW14 RS00570
gene id: 1454006:AW14_RS00570
uniprot id: A0A0C5W7Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1454006:AW14 RS09855
gene id: 1454006:AW14_RS09855
uniprot id: A0A0C5WM56
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1454006:AW14 RS08890
gene id: 1454006:AW14_RS08890
uniprot id: A0A0C5WEY4
names: Similarity
messages: Belongs to the RelE toxin family.

1454006:AW14 RS03870
gene id: 1454006:AW14_RS03870
uniprot id: A0A0C5VUV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1454006:AW14 RS07070
gene id: 1454006:AW14_RS07070
uniprot id: A0A0C5WAV1
names: Subcellular Location Annotation
messages: Secreted

1454006:AW14 RS09455
gene id: 1454006:AW14_RS09455
uniprot id: A0A0C5VXL8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1454006:AW14 RS00135
gene id: 1454006:AW14_RS00135
uniprot id: A0A0C5W592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1454006:AW14 RS10470
gene id: 1454006:AW14_RS10470
uniprot id: A0A0C5WA82
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS00540
gene id: 1454006:AW14_RS00540
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS10770
gene id: 1454006:AW14_RS10770
uniprot id: A0A0C5WAE8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1454006:AW14 RS13165
gene id: 1454006:AW14_RS13165
uniprot id: A0A0C5WH88
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS09625
gene id: 1454006:AW14_RS09625
uniprot id: A0A0C5WC64
names: Similarity
messages: Belongs to the glutathione peroxidase family.

1454006:AW14 RS04765
gene id: 1454006:AW14_RS04765
uniprot id: A0A0C5WCP4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1454006:AW14 RS05090
gene id: 1454006:AW14_RS05090
uniprot id: A0A0C5WCZ0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS11585
gene id: 1454006:AW14_RS11585
uniprot id: A0A0C5WGH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS05850
gene id: 1454006:AW14_RS05850
uniprot id: A0A0C5WKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1454006:AW14 RS12725
gene id: 1454006:AW14_RS12725
uniprot id: A0A0C5WH20
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11245
gene id: 1454006:AW14_RS11245
uniprot id: A0A0C5WAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1454006:AW14 RS07420
gene id: 1454006:AW14_RS07420
uniprot id: A0A0C5WL27
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1454006:AW14 RS12160
gene id: 1454006:AW14_RS12160
uniprot id: A0A0C5VZ65
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS10875
gene id: 1454006:AW14_RS10875
uniprot id: A0A0C5WAH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS10015
gene id: 1454006:AW14_RS10015
uniprot id: A0A0C5VXW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1454006:AW14 RS06595
gene id: 1454006:AW14_RS06595
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS09500
gene id: 1454006:AW14_RS09500
uniprot id: A0A0C5WM06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1454006:AW14 RS04100
gene id: 1454006:AW14_RS04100
uniprot id: A0A0C5W707
names: Similarity
messages: Belongs to the P(II) protein family.

1454006:AW14 RS07135
gene id: 1454006:AW14_RS07135
uniprot id: A0A0C5W8G9
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS07370
gene id: 1454006:AW14_RS07370
uniprot id: A0A0C5WL15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11750
gene id: 1454006:AW14_RS11750
uniprot id: A0A0C5WN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1454006:AW14 RS10295
gene id: 1454006:AW14_RS10295
uniprot id: A0A0C5WA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS10735
gene id: 1454006:AW14_RS10735
uniprot id: A0A0C5VYE1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1454006:AW14 RS02680
gene id: 1454006:AW14_RS02680
uniprot id: A0A0C5W906
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02295
gene id: 1454006:AW14_RS02295
uniprot id: A0A0C5W6A0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1454006:AW14 RS02650
gene id: 1454006:AW14_RS02650
uniprot id: A0A0C5VU97
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1454006:AW14 RS09280
gene id: 1454006:AW14_RS09280
uniprot id: A0A0C5W9L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1454006:AW14 RS09820
gene id: 1454006:AW14_RS09820
uniprot id: A0A0C5W9W2
names: Similarity
messages: Belongs to the universal stress protein A family.

1454006:AW14 RS09785
gene id: 1454006:AW14_RS09785
uniprot id: A0A0C5W9V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

1454006:AW14 RS06240
gene id: 1454006:AW14_RS06240
uniprot id: A0A0C5WAK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1454006:AW14 RS12000
gene id: 1454006:AW14_RS12000
uniprot id: A0A0C5WB42
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1454006:AW14 RS01495
gene id: 1454006:AW14_RS01495
uniprot id: A0A0C5W8B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1454006:AW14 RS02510
gene id: 1454006:AW14_RS02510
uniprot id: A0A0C5WBH4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1454006:AW14 RS08515
gene id: 1454006:AW14_RS08515
uniprot id: A0A0C5W991
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1454006:AW14 RS00225
gene id: 1454006:AW14_RS00225
uniprot id: A0A0C5VSX4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02565
gene id: 1454006:AW14_RS02565
uniprot id: A0A0C5WBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1454006:AW14 RS01465
gene id: 1454006:AW14_RS01465
uniprot id: A0A0C5W5U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1454006:AW14 RS10390
gene id: 1454006:AW14_RS10390
uniprot id: A0A0C5WCJ8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1454006:AW14 RS13520
gene id: 1454006:AW14_RS13520
uniprot id: A0A0C5WBT7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1454006:AW14 RS13565
gene id: 1454006:AW14_RS13565
uniprot id: A0A0C5WEB0
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1454006:AW14 RS10870
gene id: 1454006:AW14_RS10870
uniprot id: A0A0C5WCW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1454006:AW14 RS11395
gene id: 1454006:AW14_RS11395
uniprot id: A0A0C5WAU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1454006:AW14 RS02350
gene id: 1454006:AW14_RS02350
uniprot id: A0A0C5W6B0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1454006:AW14 RS04545
gene id: 1454006:AW14_RS04545
uniprot id: A0A0C5W793
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

1454006:AW14 RS03730
gene id: 1454006:AW14_RS03730
uniprot id: A0A0C5WC23
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1454006:AW14 RS03145
gene id: 1454006:AW14_RS03145
uniprot id: A0A0C5W6N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

1454006:AW14 RS06900
gene id: 1454006:AW14_RS06900
uniprot id: A0A0C5W8C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1454006:AW14 RS00880
gene id: 1454006:AW14_RS00880
uniprot id: A0A0C5W827
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1454006:AW14 RS00180
gene id: 1454006:AW14_RS00180
uniprot id: A0A0C5W7V9
names: Similarity
messages: Belongs to the peptidase C40 family.

1454006:AW14 RS13905
gene id: 1454006:AW14_RS13905
uniprot id: A0A0C5WNY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1454006:AW14 RS10750
gene id: 1454006:AW14_RS10750
uniprot id: A0A0C5WFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1454006:AW14 RS12735
gene id: 1454006:AW14_RS12735
uniprot id: A0A0C5VZE8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1454006:AW14 RS11730
gene id: 1454006:AW14_RS11730
uniprot id: A0A0C5VZ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1454006:AW14 RS05565
gene id: 1454006:AW14_RS05565
uniprot id: A0A0C5WKE5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1454006:AW14 RS06190
gene id: 1454006:AW14_RS06190
uniprot id: A0A0C5WDL7
names: Similarity
messages: Belongs to the MreC family.

1454006:AW14 RS10425
gene id: 1454006:AW14_RS10425
uniprot id: A0A0C5WFS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS05810
gene id: 1454006:AW14_RS05810
uniprot id: A0A0C5WAF0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03815
gene id: 1454006:AW14_RS03815
uniprot id: A0A0C5WJI7
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS10915
gene id: 1454006:AW14_RS10915
uniprot id: A0A0C5WG22
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1454006:AW14 RS08490
gene id: 1454006:AW14_RS08490
uniprot id: A0A0C5W984
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01095
gene id: 1454006:AW14_RS01095
uniprot id: A0A0C5WAQ3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1454006:AW14 RS08810
gene id: 1454006:AW14_RS08810
uniprot id: A0A0C5WEX4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1454006:AW14 RS07445
gene id: 1454006:AW14_RS07445
uniprot id: A0A0C5W8M5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1454006:AW14 RS07340
gene id: 1454006:AW14_RS07340
uniprot id: A0A0C5WE51
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1454006:AW14 RS00140
gene id: 1454006:AW14_RS00140
uniprot id: A0A0C5WAC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1454006:AW14 RS05065
gene id: 1454006:AW14_RS05065
uniprot id: A0A0C5WCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1454006:AW14 RS03410
gene id: 1454006:AW14_RS03410
uniprot id: A0A0C5WBW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1454006:AW14 RS12010
gene id: 1454006:AW14_RS12010
uniprot id: A0A0C5WN78
names: Similarity
messages: Belongs to the LOG family.

1454006:AW14 RS05835
gene id: 1454006:AW14_RS05835
uniprot id: A0A0C5WAF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1454006:AW14 RS03770
gene id: 1454006:AW14_RS03770
uniprot id: A0A0C5VUT6
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1454006:AW14 RS12610
gene id: 1454006:AW14_RS12610
uniprot id: A0A0C5WBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

1454006:AW14 RS02150
gene id: 1454006:AW14_RS02150
uniprot id: A0A0C5WIV4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS08360
gene id: 1454006:AW14_RS08360
uniprot id: A0A0C5WLJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Heterotrimer of A, B and C subunits.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS14120
gene id: 1454006:AW14_RS14120
uniprot id: A0A0C5WC75
names: Similarity
messages: Belongs to the glutamine synthetase family.

1454006:AW14 RS11270
gene id: 1454006:AW14_RS11270
uniprot id: A0A0C5WAS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1454006:AW14 RS09665
gene id: 1454006:AW14_RS09665
uniprot id: A0A0C5WM26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

1454006:AW14 RS05795
gene id: 1454006:AW14_RS05795
uniprot id: A0A0C5WDF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS02390
gene id: 1454006:AW14_RS02390
uniprot id: A0A0C5WIZ7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1454006:AW14 RS08460
gene id: 1454006:AW14_RS08460
uniprot id: A0A0C5W979
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1454006:AW14 RS01570
gene id: 1454006:AW14_RS01570
uniprot id: A0A0C5VTK7
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1454006:AW14 RS03170
gene id: 1454006:AW14_RS03170
uniprot id: A0A0C5W973
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1454006:AW14 RS07220
gene id: 1454006:AW14_RS07220
uniprot id: A0A0C5WAX0
names: Similarity
messages: Belongs to the CarB family.

1454006:AW14 RS11720
gene id: 1454006:AW14_RS11720
uniprot id: A0A0C5WGJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1454006:AW14 RS11965
gene id: 1454006:AW14_RS11965
uniprot id: A0A0C5VZ45
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1454006:AW14 RS04430
gene id: 1454006:AW14_RS04430
uniprot id: A0A0C5W770
names: Similarity
messages: Belongs to the YicC/YloC family.

1454006:AW14 RS03070
gene id: 1454006:AW14_RS03070
uniprot id: A0A0C5WJ96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1454006:AW14 RS00965
gene id: 1454006:AW14_RS00965
uniprot id: A0A0C5W5J9
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01440
gene id: 1454006:AW14_RS01440
uniprot id: A0A0C5W5U2
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1454006:AW14 RS00640
gene id: 1454006:AW14_RS00640
uniprot id: A0A0C5VT34
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1454006:AW14 RS07955
gene id: 1454006:AW14_RS07955
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS01660
gene id: 1454006:AW14_RS01660
uniprot id: A0A0C5WAY8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1454006:AW14 RS11145
gene id: 1454006:AW14_RS11145
uniprot id: A0A0C5VYQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1454006:AW14 RS07490
gene id: 1454006:AW14_RS07490
uniprot id: A0A0C5WB14
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1454006:AW14 RS11265
gene id: 1454006:AW14_RS11265
uniprot id: A0A0C5WD60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1454006:AW14 RS08310
gene id: 1454006:AW14_RS08310
uniprot id: A0A0C5WLI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1454006:AW14 RS10065
gene id: 1454006:AW14_RS10065
uniprot id: A0A0C5WFJ7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS13270
gene id: 1454006:AW14_RS13270
uniprot id: A0A0C5WH97
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS13190
gene id: 1454006:AW14_RS13190
uniprot id: A0A0C5WD28
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1454006:AW14 RS02730
gene id: 1454006:AW14_RS02730
uniprot id: A0A0C5VUD5
names: Similarity
messages: Belongs to the peptidase S24 family.

1454006:AW14 RS01145
gene id: 1454006:AW14_RS01145
uniprot id: A0A0C5WAR3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1454006:AW14 RS00280
gene id: 1454006:AW14_RS00280
uniprot id: A0A0C5WHZ8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1454006:AW14 RS13885
gene id: 1454006:AW14_RS13885
uniprot id: A0A0C5W022
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS05050
gene id: 1454006:AW14_RS05050
uniprot id: A0A0C5VVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1454006:AW14 RS06655
gene id: 1454006:AW14_RS06655
uniprot id: A0A0C5VWB2
names: Similarity
messages: Belongs to the RelE toxin family.

1454006:AW14 RS01120
gene id: 1454006:AW14_RS01120
uniprot id: A0A0C5WAQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1454006:AW14 RS01845
gene id: 1454006:AW14_RS01845
uniprot id: A0A0C5VTQ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1454006:AW14 RS00465
gene id: 1454006:AW14_RS00465
uniprot id: A0A0C5WAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1454006:AW14 RS09460
gene id: 1454006:AW14_RS09460
uniprot id: A0A0C5WC40
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1454006:AW14 RS08945
gene id: 1454006:AW14_RS08945
uniprot id: A0A0C5WLU2
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1454006:AW14 RS05275
gene id: 1454006:AW14_RS05275
uniprot id: A0A0C5WD37
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1454006:AW14 RS11360
gene id: 1454006:AW14_RS11360
uniprot id: A0A0C5VYU5
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1454006:AW14 RS01110
gene id: 1454006:AW14_RS01110
uniprot id: A0A0C5W857
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1454006:AW14 RS09560
gene id: 1454006:AW14_RS09560
uniprot id: A0A0C5WF86
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1454006:AW14 RS02670
gene id: 1454006:AW14_RS02670
uniprot id: A0A0C5WJ47
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1454006:AW14 RS03525
gene id: 1454006:AW14_RS03525
uniprot id: A0A0C5VUQ4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1454006:AW14 RS05100
gene id: 1454006:AW14_RS05100
uniprot id: A0A0C5VVI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1454006:AW14 RS13360
gene id: 1454006:AW14_RS13360
uniprot id: A0A0C5WBQ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1454006:AW14 RS02515
gene id: 1454006:AW14_RS02515
uniprot id: A0A0C5WJ17
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1454006:AW14 RS04140
gene id: 1454006:AW14_RS04140
uniprot id: A0A0C5WJP7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS04990
gene id: 1454006:AW14_RS04990
uniprot id: A0A0C5VVG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1454006:AW14 RS05695
gene id: 1454006:AW14_RS05695
uniprot id: A0A0C5WDE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS04710
gene id: 1454006:AW14_RS04710
uniprot id: A0A0C5WJZ2
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1454006:AW14 RS06885
gene id: 1454006:AW14_RS06885
uniprot id: A0A0C5WKT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

1454006:AW14 RS10535
gene id: 1454006:AW14_RS10535
uniprot id: A0A0C5WFU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1454006:AW14 RS13050
gene id: 1454006:AW14_RS13050
uniprot id: A0A0C5VZK8
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS04830
gene id: 1454006:AW14_RS04830
uniprot id: A0A0C5WK11
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1454006:AW14 RS05125
gene id: 1454006:AW14_RS05125
uniprot id: A0A0C5VVJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1454006:AW14 RS13740
gene id: 1454006:AW14_RS13740
uniprot id: A0A0C5WHG5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1454006:AW14 RS06865
gene id: 1454006:AW14_RS06865
uniprot id: A0A0C5VWE1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1454006:AW14 RS11605
gene id: 1454006:AW14_RS11605
uniprot id: A0A0C5WAY7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1454006:AW14 RS04945
gene id: 1454006:AW14_RS04945
uniprot id: A0A0C5W9W7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1454006:AW14 RS09435
gene id: 1454006:AW14_RS09435
uniprot id: A0A0C5WC39
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS11775
gene id: 1454006:AW14_RS11775
uniprot id: A0A0C5WGK5
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1454006:AW14 RS12400
gene id: 1454006:AW14_RS12400
uniprot id: A0A0C5WDN7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1454006:AW14 RS05670
gene id: 1454006:AW14_RS05670
uniprot id: A0A0C5WKH1
names: Similarity
messages: Belongs to the fabD family.

1454006:AW14 RS03990
gene id: 1454006:AW14_RS03990
uniprot id: A0A0C5WJM0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00390
gene id: 1454006:AW14_RS00390
uniprot id: A0A0C5VT01
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1454006:AW14 RS02820
gene id: 1454006:AW14_RS02820
uniprot id: A0A0C5W6K9
names: Similarity
messages: Belongs to the ArsC family.

1454006:AW14 RS09760
gene id: 1454006:AW14_RS09760
uniprot id: A0A0C5W9V1
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS11130
gene id: 1454006:AW14_RS11130
uniprot id: A0A0C5WAN8
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

1454006:AW14 RS01010
gene id: 1454006:AW14_RS01010
uniprot id: A0A0C5W845
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1454006:AW14 RS07875
gene id: 1454006:AW14_RS07875
uniprot id: A0A0C5VWT2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1454006:AW14 RS05745
gene id: 1454006:AW14_RS05745
uniprot id: A0A0C5VVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1454006:AW14 RS03175
gene id: 1454006:AW14_RS03175
uniprot id: A0A0C5W6N5
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

1454006:AW14 RS09730
gene id: 1454006:AW14_RS09730
uniprot id: A0A0C5W9U5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1454006:AW14 RS08315
gene id: 1454006:AW14_RS08315
uniprot id: A0A0C5VX23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1454006:AW14 RS06685
gene id: 1454006:AW14_RS06685
uniprot id: A0A0C5WDR6
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

1454006:AW14 RS06940
gene id: 1454006:AW14_RS06940
uniprot id: A0A0C5WAT2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS02520
gene id: 1454006:AW14_RS02520
uniprot id: A0A0C5VU63
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1454006:AW14 RS05620
gene id: 1454006:AW14_RS05620
uniprot id: A0A0C5WKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS06915
gene id: 1454006:AW14_RS06915
uniprot id: A0A0C5WDW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

1454006:AW14 RS08660
gene id: 1454006:AW14_RS08660
uniprot id: A0A0C5W0P4
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS01150
gene id: 1454006:AW14_RS01150
uniprot id: A0A0C5WID6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1454006:AW14 RS05910
gene id: 1454006:AW14_RS05910
uniprot id: A0A0C5VW18
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1454006:AW14 RS02605
gene id: 1454006:AW14_RS02605
uniprot id: A0A0C5W8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1454006:AW14 RS05890
gene id: 1454006:AW14_RS05890
uniprot id: A0A0C5WAG0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1454006:AW14 RS12410
gene id: 1454006:AW14_RS12410
uniprot id: A0A0C5WGV9
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1454006:AW14 RS11805
gene id: 1454006:AW14_RS11805
uniprot id: A0A0C5WN55
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1454006:AW14 RS05665
gene id: 1454006:AW14_RS05665
uniprot id: A0A0C5WDD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1454006:AW14 RS06890
gene id: 1454006:AW14_RS06890
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS08050
gene id: 1454006:AW14_RS08050
uniprot id: A0A0C5WEI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1454006:AW14 RS03975
gene id: 1454006:AW14_RS03975
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS04575
gene id: 1454006:AW14_RS04575
uniprot id: A0A0C5WCJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1454006:AW14 RS04535
gene id: 1454006:AW14_RS04535
uniprot id: A0A0C5VV64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1454006:AW14 RS13665
gene id: 1454006:AW14_RS13665
uniprot id: A0A0C5WNT9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS00695
gene id: 1454006:AW14_RS00695
uniprot id: A0A0C5W804
names: Similarity
messages: Belongs to the CIA30 family.

1454006:AW14 RS01340
gene id: 1454006:AW14_RS01340
uniprot id: A0A0C5W5S0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01320
gene id: 1454006:AW14_RS01320
uniprot id: A0A0C5WAU0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1454006:AW14 RS07005
gene id: 1454006:AW14_RS07005
uniprot id: A0A0C5WKV4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

1454006:AW14 RS09480
gene id: 1454006:AW14_RS09480
uniprot id: A0A0C5VXM4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00975
gene id: 1454006:AW14_RS00975
uniprot id: A0A0C5WIA3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS05110
gene id: 1454006:AW14_RS05110
uniprot id: A0A0C5W7L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1454006:AW14 RS02655
gene id: 1454006:AW14_RS02655
uniprot id: A0A0C5W8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1454006:AW14 RS13695
gene id: 1454006:AW14_RS13695
uniprot id: A0A0C5VZY5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1454006:AW14 RS13130
gene id: 1454006:AW14_RS13130
uniprot id: A0A0C5WII1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS08385
gene id: 1454006:AW14_RS08385
uniprot id: A0A0C5WLJ6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1454006:AW14 RS02155
gene id: 1454006:AW14_RS02155
uniprot id: A0A0C5VTW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1454006:AW14 RS11940
gene id: 1454006:AW14_RS11940
uniprot id: A0A0C5VZ42
names: Similarity
messages: Belongs to the ArsC family.

1454006:AW14 RS12525
gene id: 1454006:AW14_RS12525
uniprot id: A0A0C5WDR1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS09745
gene id: 1454006:AW14_RS09745
uniprot id: A0A0C5WM37
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1454006:AW14 RS05965
gene id: 1454006:AW14_RS05965
uniprot id: A0A0C5WAH2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1454006:AW14 RS12035
gene id: 1454006:AW14_RS12035
uniprot id: A0A0C5WGP8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1454006:AW14 RS11710
gene id: 1454006:AW14_RS11710
uniprot id: A0A0C5WDE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1454006:AW14 RS06720
gene id: 1454006:AW14_RS06720
uniprot id: A0A0C5WKR8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS10810
gene id: 1454006:AW14_RS10810
uniprot id: A0A0C5VYG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS10155
gene id: 1454006:AW14_RS10155
uniprot id: A0A0C5VXZ3
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1454006:AW14 RS03850
gene id: 1454006:AW14_RS03850
uniprot id: A0A0C5W9E5
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00580
gene id: 1454006:AW14_RS00580
uniprot id: A0A0C5WAI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1454006:AW14 RS04610
gene id: 1454006:AW14_RS04610
uniprot id: A0A0C5VV82
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1454006:AW14 RS01195
gene id: 1454006:AW14_RS01195
uniprot id: A0A0C5WAS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1454006:AW14 RS08965
gene id: 1454006:AW14_RS08965
uniprot id: A0A0C5WEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1454006:AW14 RS01060
gene id: 1454006:AW14_RS01060
uniprot id: A0A0C5W851
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1454006:AW14 RS04755
gene id: 1454006:AW14_RS04755
uniprot id: A0A0C5W9S3
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1454006:AW14 RS02325
gene id: 1454006:AW14_RS02325
uniprot id: A0A0C5WBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1454006:AW14 RS12560
gene id: 1454006:AW14_RS12560
uniprot id: A0A0C5WGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1454006:AW14 RS09530
gene id: 1454006:AW14_RS09530
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS10570
gene id: 1454006:AW14_RS10570
uniprot id: A0A0C5VY94
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS10605
gene id: 1454006:AW14_RS10605
uniprot id: A0A0C5WCP6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

1454006:AW14 RS03590
gene id: 1454006:AW14_RS03590
uniprot id: A0A0C5WJF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1454006:AW14 RS11645
gene id: 1454006:AW14_RS11645
uniprot id: A0A0C5WGI6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1454006:AW14 RS03840
gene id: 1454006:AW14_RS03840
uniprot id: A0A0C5WJJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1454006:AW14 RS08095
gene id: 1454006:AW14_RS08095
uniprot id: A0A0C5WBE5
names: Similarity
messages: Belongs to the peptidase S51 family.

1454006:AW14 RS04205
gene id: 1454006:AW14_RS04205
uniprot id: A0A0C5WJQ6
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS10325
gene id: 1454006:AW14_RS10325
uniprot id: A0A0C5WFQ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03390
gene id: 1454006:AW14_RS03390
uniprot id: A0A0C5VUN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1454006:AW14 RS08435
gene id: 1454006:AW14_RS08435
uniprot id: A0A0C5W970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1454006:AW14 RS14070
gene id: 1454006:AW14_RS14070
uniprot id: A0A0C5WHL4
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1454006:AW14 RS12145
gene id: 1454006:AW14_RS12145
uniprot id: A0A0C5WB65
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS07925
gene id: 1454006:AW14_RS07925
uniprot id: A0A0C5VWT9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1454006:AW14 RS01085
gene id: 1454006:AW14_RS01085
uniprot id: A0A0C5W856
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1454006:AW14 RS11015
gene id: 1454006:AW14_RS11015
uniprot id: A0A0C5VYL4
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01835
gene id: 1454006:AW14_RS01835
uniprot id: A0A0C5WB17
names: Similarity
messages: Belongs to the transketolase family.

1454006:AW14 RS09485
gene id: 1454006:AW14_RS09485
uniprot id: A0A0C5WC44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1454006:AW14 RS06085
gene id: 1454006:AW14_RS06085
uniprot id: A0A0C5WKL0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1454006:AW14 RS09205
gene id: 1454006:AW14_RS09205
uniprot id: A0A0C5WF23
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1454006:AW14 RS12770
gene id: 1454006:AW14_RS12770
uniprot id: A0A0C5WBH2
names: Similarity
messages: Belongs to the nitroreductase family.

1454006:AW14 RS09310
gene id: 1454006:AW14_RS09310
uniprot id: A0A0C5WF38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1454006:AW14 RS11025
gene id: 1454006:AW14_RS11025
uniprot id: A0A0C5WAL3
names: Similarity
messages: Belongs to the UPF0173 family.

1454006:AW14 RS09025
gene id: 1454006:AW14_RS09025
uniprot id: A0A0C5WEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1454006:AW14 RS05845
gene id: 1454006:AW14_RS05845
uniprot id: A0A0C5WDF7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS04865
gene id: 1454006:AW14_RS04865
uniprot id: A0A0C5W9U6
names: Similarity
messages: Belongs to the peptidase S8 family.

1454006:AW14 RS13800
gene id: 1454006:AW14_RS13800
uniprot id: A0A0C5WBZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1454006:AW14 RS02720
gene id: 1454006:AW14_RS02720
uniprot id: A0A0C5WBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1454006:AW14 RS10505
gene id: 1454006:AW14_RS10505
uniprot id: A0A0C5WA88
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1454006:AW14 RS09850
gene id: 1454006:AW14_RS09850
uniprot id: A0A0C5WFF2
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01345
gene id: 1454006:AW14_RS01345
uniprot id: A0A0C5WAU5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1454006:AW14 RS12580
gene id: 1454006:AW14_RS12580
uniprot id: A0A0C5WDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS03985
gene id: 1454006:AW14_RS03985
uniprot id: A0A0C5WC70
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1454006:AW14 RS11735
gene id: 1454006:AW14_RS11735
uniprot id: A0A0C5WDE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1454006:AW14 RS07500
gene id: 1454006:AW14_RS07500
uniprot id: A0A0C5WE86
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01070
gene id: 1454006:AW14_RS01070
uniprot id: A0A0C5WAQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1454006:AW14 RS10685
gene id: 1454006:AW14_RS10685
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS13600
gene id: 1454006:AW14_RS13600
uniprot id: A0A0C5WHE5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1454006:AW14 RS12995
gene id: 1454006:AW14_RS12995
uniprot id: A0A0C5WBK5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1454006:AW14 RS08190
gene id: 1454006:AW14_RS08190
uniprot id: A0A0C5WEL4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1454006:AW14 RS04940
gene id: 1454006:AW14_RS04940
uniprot id: A0A0C5VVF1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1454006:AW14 RS09505
gene id: 1454006:AW14_RS09505
uniprot id: A0A0C5VXM8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1454006:AW14 RS04560
gene id: 1454006:AW14_RS04560
uniprot id: A0A0C5VV70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1454006:AW14 RS04075
gene id: 1454006:AW14_RS04075
uniprot id: A0A0C5W701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1454006:AW14 RS02030
gene id: 1454006:AW14_RS02030
uniprot id: A0A0C5W8L8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1454006:AW14 RS13865
gene id: 1454006:AW14_RS13865
uniprot id: A0A0C5WEG8
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS10430
gene id: 1454006:AW14_RS10430
uniprot id: A0A0C5WMC8
names: Similarity
messages: Belongs to the peptidase S8 family.

1454006:AW14 RS08075
gene id: 1454006:AW14_RS08075
uniprot id: A0A0C5WEJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1454006:AW14 RS12865
gene id: 1454006:AW14_RS12865
uniprot id: A0A0C5VZH5
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS13000
gene id: 1454006:AW14_RS13000
uniprot id: A0A0C5WH63
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS03330
gene id: 1454006:AW14_RS03330
uniprot id: A0A0C5VUM1
names: Similarity
messages: Belongs to the DprA/Smf family.

1454006:AW14 RS10485
gene id: 1454006:AW14_RS10485
uniprot id: A0A0C5WMD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1454006:AW14 RS02220
gene id: 1454006:AW14_RS02220
uniprot id: A0A0C5W685
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required for cell division and gliding motility.

1454006:AW14 RS10855
gene id: 1454006:AW14_RS10855
uniprot id: A0A0C5WG11
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1454006:AW14 RS04080
gene id: 1454006:AW14_RS04080
uniprot id: A0A0C5WC83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1454006:AW14 RS05650
gene id: 1454006:AW14_RS05650
uniprot id: A0A0C5VVW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1454006:AW14 RS13620
gene id: 1454006:AW14_RS13620
uniprot id: A0A0C5WEC1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1454006:AW14 RS06835
gene id: 1454006:AW14_RS06835
uniprot id: A0A0C5WKT0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1454006:AW14 RS13485
gene id: 1454006:AW14_RS13485
uniprot id: A0A0C5WE88
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1454006:AW14 RS06805
gene id: 1454006:AW14_RS06805
uniprot id: A0A0C5WDU1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1454006:AW14 RS04930
gene id: 1454006:AW14_RS04930
uniprot id: A0A0C5WCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

1454006:AW14 RS14515
gene id: 1454006:AW14_RS14515
uniprot id: A0A0C5WAD4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1454006:AW14 RS09825
gene id: 1454006:AW14_RS09825
uniprot id: A0A0C5WFE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS14130
gene id: 1454006:AW14_RS14130
uniprot id: A0A0C5WP24
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS13985
gene id: 1454006:AW14_RS13985
uniprot id: A0A0C5WC42
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS11700
gene id: 1454006:AW14_RS11700
uniprot id: A0A0C5WN43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1454006:AW14 RS01155
gene id: 1454006:AW14_RS01155
uniprot id: A0A0C5VTD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1454006:AW14 RS13540
gene id: 1454006:AW14_RS13540
uniprot id: A0A0C5WEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1454006:AW14 RS07080
gene id: 1454006:AW14_RS07080
uniprot id: A0A0C5WDZ9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1454006:AW14 RS01075
gene id: 1454006:AW14_RS01075
uniprot id: A0A0C5WIC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1454006:AW14 RS07425
gene id: 1454006:AW14_RS07425
uniprot id: A0A0C5VWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS06455
gene id: 1454006:AW14_RS06455
uniprot id: A0A0C5WKP9
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1454006:AW14 RS14005
gene id: 1454006:AW14_RS14005
uniprot id: A0A0C5WEJ9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1454006:AW14 RS04065
gene id: 1454006:AW14_RS04065
uniprot id: A0A0C5W9G8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11310
gene id: 1454006:AW14_RS11310
uniprot id: A0A0C5WAS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS08415
gene id: 1454006:AW14_RS08415
uniprot id: A0A0C5WEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1454006:AW14 RS12435
gene id: 1454006:AW14_RS12435
uniprot id: A0A0C5WGW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1454006:AW14 RS11450
gene id: 1454006:AW14_RS11450
uniprot id: A0A0C5WGD0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS10410
gene id: 1454006:AW14_RS10410
uniprot id: A0A0C5VY51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1454006:AW14 RS05995
gene id: 1454006:AW14_RS05995
uniprot id: A0A0C5WAH5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1454006:AW14 RS02415
gene id: 1454006:AW14_RS02415
uniprot id: A0A0C5W8U7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00160
gene id: 1454006:AW14_RS00160
uniprot id: A0A0C5W596
names: Similarity
messages: Belongs to the peptidase S41A family.

1454006:AW14 RS04295
gene id: 1454006:AW14_RS04295
uniprot id: A0A0C5WJS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1454006:AW14 RS08160
gene id: 1454006:AW14_RS08160
uniprot id: A0A0C5WEK6
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

1454006:AW14 RS05115
gene id: 1454006:AW14_RS05115
uniprot id: A0A0C5WCZ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1454006:AW14 RS08600
gene id: 1454006:AW14_RS08600
uniprot id: A0A0C5WET6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1454006:AW14 RS07455
gene id: 1454006:AW14_RS07455
uniprot id: A0A0C5WL33
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11680
gene id: 1454006:AW14_RS11680
uniprot id: A0A0C5VZ16
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1454006:AW14 RS01930
gene id: 1454006:AW14_RS01930
uniprot id: A0A0C5W8K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1454006:AW14 RS03660
gene id: 1454006:AW14_RS03660
uniprot id: A0A0C5W9C3
names: Similarity
messages: Belongs to the Skp family.

1454006:AW14 RS07245
gene id: 1454006:AW14_RS07245
uniprot id: A0A0C5VWJ4
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1454006:AW14 RS09470
gene id: 1454006:AW14_RS09470
uniprot id: A0A0C5WF66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1454006:AW14 RS05685
gene id: 1454006:AW14_RS05685
uniprot id: A0A0C5WAC9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1454006:AW14 RS04910
gene id: 1454006:AW14_RS04910
uniprot id: A0A0C5WK26
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS09600
gene id: 1454006:AW14_RS09600
uniprot id: A0A0C5WC60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS04810
gene id: 1454006:AW14_RS04810
uniprot id: A0A0C5W9T6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1454006:AW14 RS03520
gene id: 1454006:AW14_RS03520
uniprot id: A0A0C5WJE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1454006:AW14 RS12740
gene id: 1454006:AW14_RS12740
uniprot id: A0A0C5WDV8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1454006:AW14 RS02450
gene id: 1454006:AW14_RS02450
uniprot id: A0A0C5W6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1454006:AW14 RS06715
gene id: 1454006:AW14_RS06715
uniprot id: A0A0C5WDS0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS05425
gene id: 1454006:AW14_RS05425
uniprot id: A0A0C5WD78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1454006:AW14 RS10555
gene id: 1454006:AW14_RS10555
uniprot id: A0A0C5WA99
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS11320
gene id: 1454006:AW14_RS11320
uniprot id: A0A0C5WMW9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS00565
gene id: 1454006:AW14_RS00565
uniprot id: A0A0C5VT25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1454006:AW14 RS06135
gene id: 1454006:AW14_RS06135
uniprot id: A0A0C5W836
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS00530
gene id: 1454006:AW14_RS00530
uniprot id: A0A0C5WP64
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

1454006:AW14 RS11870
gene id: 1454006:AW14_RS11870
uniprot id: A0A0C5WB21
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04130
gene id: 1454006:AW14_RS04130
uniprot id: A0A0C5W712
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS05325
gene id: 1454006:AW14_RS05325
uniprot id: A0A0C5WD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Membrane

1454006:AW14 RS08395
gene id: 1454006:AW14_RS08395
uniprot id: A0A0C5VX42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1454006:AW14 RS08595
gene id: 1454006:AW14_RS08595
uniprot id: A0A0C5W9B2
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1454006:AW14 RS11980
gene id: 1454006:AW14_RS11980
uniprot id: A0A0C5WGN9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1454006:AW14 RS01820
gene id: 1454006:AW14_RS01820
uniprot id: A0A0C5VTQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS06050
gene id: 1454006:AW14_RS06050
uniprot id: A0A0C5W828
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1454006:AW14 RS09495
gene id: 1454006:AW14_RS09495
uniprot id: A0A0C5WF72
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1454006:AW14 RS04465
gene id: 1454006:AW14_RS04465
uniprot id: A0A0C5W776
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1454006:AW14 RS07265
gene id: 1454006:AW14_RS07265
uniprot id: A0A0C5WKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS03300
gene id: 1454006:AW14_RS03300
uniprot id: A0A0C5VUL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1454006:AW14 RS07515
gene id: 1454006:AW14_RS07515
uniprot id: A0A0C5WB20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1454006:AW14 RS13545
gene id: 1454006:AW14_RS13545
uniprot id: A0A0C5WBU4
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1454006:AW14 RS12365
gene id: 1454006:AW14_RS12365
uniprot id: A0A0C5WNB9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1454006:AW14 RS13775
gene id: 1454006:AW14_RS13775
uniprot id: A0A0C5WBY8
names: Similarity
messages: Belongs to the sterol desaturase family.

1454006:AW14 RS09995
gene id: 1454006:AW14_RS09995
uniprot id: A0A0C5WCB2
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02705
gene id: 1454006:AW14_RS02705
uniprot id: A0A0C5VUB2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS05435
gene id: 1454006:AW14_RS05435
uniprot id: A0A0C5VVS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS07110
gene id: 1454006:AW14_RS07110
uniprot id: A0A0C5W8G5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS02435
gene id: 1454006:AW14_RS02435
uniprot id: A0A0C5WJ01
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1454006:AW14 RS05655
gene id: 1454006:AW14_RS05655
uniprot id: A0A0C5WAB2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1454006:AW14 RS08235
gene id: 1454006:AW14_RS08235
uniprot id: A0A0C5WBH7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1454006:AW14 RS10805
gene id: 1454006:AW14_RS10805
uniprot id: A0A0C5WMJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1454006:AW14 RS03360
gene id: 1454006:AW14_RS03360
uniprot id: A0A0C5WJC7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1454006:AW14 RS02500
gene id: 1454006:AW14_RS02500
uniprot id: A0A0C5W8W5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1454006:AW14 RS00480
gene id: 1454006:AW14_RS00480
uniprot id: A0A0C5W7Y4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1454006:AW14 RS14125
gene id: 1454006:AW14_RS14125
uniprot id: A0A0C5WHM6
names: Similarity
messages: Belongs to the glutamine synthetase family.

1454006:AW14 RS11005
gene id: 1454006:AW14_RS11005
uniprot id: A0A0C5WMP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1454006:AW14 RS08815
gene id: 1454006:AW14_RS08815
uniprot id: A0A0C5WLT3
names: Similarity
messages: Belongs to the Dps family.

1454006:AW14 RS00990
gene id: 1454006:AW14_RS00990
uniprot id: A0A0C5W5K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1454006:AW14 RS06820
gene id: 1454006:AW14_RS06820
uniprot id: A0A0C5WAR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS12650
gene id: 1454006:AW14_RS12650
uniprot id: A0A0C5VZC7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1454006:AW14 RS03190
gene id: 1454006:AW14_RS03190
uniprot id: A0A0C5VUJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS07845
gene id: 1454006:AW14_RS07845
uniprot id: A0A0C5VWS8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1454006:AW14 RS09875
gene id: 1454006:AW14_RS09875
uniprot id: A0A0C5WFF7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04440
gene id: 1454006:AW14_RS04440
uniprot id: A0A0C5WJU2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1454006:AW14 RS00110
gene id: 1454006:AW14_RS00110
uniprot id: A0A0C5W591
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1454006:AW14 RS02165
gene id: 1454006:AW14_RS02165
uniprot id: A0A0C5W674
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS09335
gene id: 1454006:AW14_RS09335
uniprot id: A0A0C5WF42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS08655
gene id: 1454006:AW14_RS08655
uniprot id: A0A0C5WPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS07305
gene id: 1454006:AW14_RS07305
uniprot id: A0A0C5WAY2
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1454006:AW14 RS02130
gene id: 1454006:AW14_RS02130
uniprot id: A0A0C5VTW1
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1454006:AW14 RS12645
gene id: 1454006:AW14_RS12645
uniprot id: A0A0C5WNG3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1454006:AW14 RS08855
gene id: 1454006:AW14_RS08855
uniprot id: A0A0C5WBX1
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04655
gene id: 1454006:AW14_RS04655
uniprot id: A0A0C5WCL3
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS05975
gene id: 1454006:AW14_RS05975
uniprot id: A0A0C5WDH9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS12295
gene id: 1454006:AW14_RS12295
uniprot id: A0A0C5WGT9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01140
gene id: 1454006:AW14_RS01140
uniprot id: A0A0C5W5N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1454006:AW14 RS04285
gene id: 1454006:AW14_RS04285
uniprot id: A0A0C5W747
names: Similarity
messages: Belongs to the ribF family.

1454006:AW14 RS05915
gene id: 1454006:AW14_RS05915
uniprot id: A0A0C5WAG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1454006:AW14 RS03215
gene id: 1454006:AW14_RS03215
uniprot id: A0A0C5VUK3
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1454006:AW14 RS04820
gene id: 1454006:AW14_RS04820
uniprot id: A0A0C5W7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1454006:AW14 RS00490
gene id: 1454006:AW14_RS00490
uniprot id: A0A0C5WAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS05330
gene id: 1454006:AW14_RS05330
uniprot id: A0A0C5WKA7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS13595
gene id: 1454006:AW14_RS13595
uniprot id: A0A0C5WBV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1454006:AW14 RS11305
gene id: 1454006:AW14_RS11305
uniprot id: A0A0C5WD65
names: Similarity
messages: Belongs to the threonine synthase family.

1454006:AW14 RS07895
gene id: 1454006:AW14_RS07895
uniprot id: A0A0C5WLA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1454006:AW14 RS04020
gene id: 1454006:AW14_RS04020
uniprot id: A0A0C5VUX7
names: Similarity
messages: Belongs to the peptidase S41A family.

1454006:AW14 RS02955
gene id: 1454006:AW14_RS02955
uniprot id: A0A0C5W954
names: Similarity
messages: Belongs to the histone deacetylase family.

1454006:AW14 RS06140
gene id: 1454006:AW14_RS06140
uniprot id: A0A0C5WDK7
names: Similarity
messages: Belongs to the NAD synthetase family.

1454006:AW14 RS13420
gene id: 1454006:AW14_RS13420
uniprot id: A0A0C5WHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1454006:AW14 RS02785
gene id: 1454006:AW14_RS02785
uniprot id: A0A0C5VUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS00340
gene id: 1454006:AW14_RS00340
uniprot id: A0A0C5VSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1454006:AW14 RS01215
gene id: 1454006:AW14_RS01215
uniprot id: A0A0C5W5Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS09515
gene id: 1454006:AW14_RS09515
uniprot id: A0A0C5W9Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS13435
gene id: 1454006:AW14_RS13435
uniprot id: A0A0C5WE79
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1454006:AW14 RS13820
gene id: 1454006:AW14_RS13820
uniprot id: A0A0C5WNW9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1454006:AW14 RS00275
gene id: 1454006:AW14_RS00275
uniprot id: A0A0C5WAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1454006:AW14 RS12315
gene id: 1454006:AW14_RS12315
uniprot id: A0A0C5WDM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1454006:AW14 RS03505
gene id: 1454006:AW14_RS03505
uniprot id: A0A0C5W9A9
names: Similarity
messages: Belongs to the GARS family.

1454006:AW14 RS00865
gene id: 1454006:AW14_RS00865
uniprot id: A0A0C5WAL8
names: Similarity
messages: Belongs to the TrpC family.

1454006:AW14 RS06280
gene id: 1454006:AW14_RS06280
uniprot id: A0A0C5WKN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1454006:AW14 RS12710
gene id: 1454006:AW14_RS12710
uniprot id: A0A0C5VZE1
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS09275
gene id: 1454006:AW14_RS09275
uniprot id: A0A0C5WC16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS07480
gene id: 1454006:AW14_RS07480
uniprot id: A0A0C5WL39
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1454006:AW14 RS00155
gene id: 1454006:AW14_RS00155
uniprot id: A0A0C5W7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1454006:AW14 RS06285
gene id: 1454006:AW14_RS06285
uniprot id: A0A0C5VW75
names: Similarity
messages: Belongs to the arginase family.

1454006:AW14 RS09565
gene id: 1454006:AW14_RS09565
uniprot id: A0A0C5WM12
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1454006:AW14 RS03580
gene id: 1454006:AW14_RS03580
uniprot id: A0A0C5W6T4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS04825
gene id: 1454006:AW14_RS04825
uniprot id: A0A0C5WCR1
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

1454006:AW14 RS09475
gene id: 1454006:AW14_RS09475
uniprot id: A0A0C5WM02
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1454006:AW14 RS00115
gene id: 1454006:AW14_RS00115
uniprot id: A0A0C5WAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS06710
gene id: 1454006:AW14_RS06710
uniprot id: A0A0C5W890
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

1454006:AW14 RS06790
gene id: 1454006:AW14_RS06790
uniprot id: A0A0C5VWD0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1454006:AW14 RS01180
gene id: 1454006:AW14_RS01180
uniprot id: A0A0C5VTD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1454006:AW14 RS07470
gene id: 1454006:AW14_RS07470
uniprot id: A0A0C5W8N1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS06870
gene id: 1454006:AW14_RS06870
uniprot id: A0A0C5WAS4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1454006:AW14 RS09385
gene id: 1454006:AW14_RS09385
uniprot id: A0A0C5W9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Mitochondrion

1454006:AW14 RS03595
gene id: 1454006:AW14_RS03595
uniprot id: A0A0C5VUR5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1454006:AW14 RS10205
gene id: 1454006:AW14_RS10205
uniprot id: A0A0C5VY00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1454006:AW14 RS08300
gene id: 1454006:AW14_RS08300
uniprot id: A0A0C5WEN5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS06055
gene id: 1454006:AW14_RS06055
uniprot id: A0A0C5WDJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS09920
gene id: 1454006:AW14_RS09920
uniprot id: A0A0C5W9Y0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS13585
gene id: 1454006:AW14_RS13585
uniprot id: A0A0C5VZW7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1454006:AW14 RS00780
gene id: 1454006:AW14_RS00780
uniprot id: A0A0C5WAK7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1454006:AW14 RS02060
gene id: 1454006:AW14_RS02060
uniprot id: A0A0C5W8M3
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1454006:AW14 RS09380
gene id: 1454006:AW14_RS09380
uniprot id: A0A0C5WC33
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1454006:AW14 RS02630
gene id: 1454006:AW14_RS02630
uniprot id: A0A0C5W8Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1454006:AW14 RS10800
gene id: 1454006:AW14_RS10800
uniprot id: A0A0C5WG01
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1454006:AW14 RS03295
gene id: 1454006:AW14_RS03295
uniprot id: A0A0C5WJC2
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1454006:AW14 RS05230
gene id: 1454006:AW14_RS05230
uniprot id: A0A0C5VVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1454006:AW14 RS09710
gene id: 1454006:AW14_RS09710
uniprot id: A0A0C5WFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS09870
gene id: 1454006:AW14_RS09870
uniprot id: A0A0C5W9X0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1454006:AW14 RS12235
gene id: 1454006:AW14_RS12235
uniprot id: A0A0C5WB77
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1454006:AW14 RS13450
gene id: 1454006:AW14_RS13450
uniprot id: A0A0C5WNR2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11260
gene id: 1454006:AW14_RS11260
uniprot id: A0A0C5VYS7
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

1454006:AW14 RS08020
gene id: 1454006:AW14_RS08020
uniprot id: A0A0C5W8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1454006:AW14 RS03575
gene id: 1454006:AW14_RS03575
uniprot id: A0A0C5W9B5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1454006:AW14 RS00920
gene id: 1454006:AW14_RS00920
uniprot id: A0A0C5WI92
names: Similarity
messages: Belongs to the DEAD box helicase family.

1454006:AW14 RS00955
gene id: 1454006:AW14_RS00955
uniprot id: A0A0C5VT92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1454006:AW14 RS04645
gene id: 1454006:AW14_RS04645
uniprot id: A0A0C5W9P9
names: Similarity
messages: Belongs to the universal stress protein A family.

1454006:AW14 RS08145
gene id: 1454006:AW14_RS08145
uniprot id: A0A0C5WBF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

1454006:AW14 RS10150
gene id: 1454006:AW14_RS10150
uniprot id: A0A0C5WM92
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS13920
gene id: 1454006:AW14_RS13920
uniprot id: A0A0C5WC27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1454006:AW14 RS01170
gene id: 1454006:AW14_RS01170
uniprot id: A0A0C5WAR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1454006:AW14 RS13765
gene id: 1454006:AW14_RS13765
uniprot id: A0A0C5VZZ8
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1454006:AW14 RS08675
gene id: 1454006:AW14_RS08675
uniprot id: A0A0C5WEU7
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS00635
gene id: 1454006:AW14_RS00635
uniprot id: A0A0C5WI44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1454006:AW14 RS04565
gene id: 1454006:AW14_RS04565
uniprot id: A0A0C5W9N2
names: Similarity
messages: Belongs to the pyruvate kinase family.

1454006:AW14 RS07155
gene id: 1454006:AW14_RS07155
uniprot id: A0A0C5WAW2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

1454006:AW14 RS07030
gene id: 1454006:AW14_RS07030
uniprot id: A0A0C5WKV9
names: Similarity
messages: Belongs to the universal stress protein A family.

1454006:AW14 RS06130
gene id: 1454006:AW14_RS06130
uniprot id: A0A0C5WAJ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1454006:AW14 RS09180
gene id: 1454006:AW14_RS09180
uniprot id: A0A0C5WLW1
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1454006:AW14 RS13955
gene id: 1454006:AW14_RS13955
uniprot id: A0A0C5WC34
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

1454006:AW14 RS08040
gene id: 1454006:AW14_RS08040
uniprot id: A0A0C5WBD1
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02070
gene id: 1454006:AW14_RS02070
uniprot id: A0A0C5WB67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1454006:AW14 RS08180
gene id: 1454006:AW14_RS08180
uniprot id: A0A0C5WBG4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1454006:AW14 RS11175
gene id: 1454006:AW14_RS11175
uniprot id: A0A0C5VYQ7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS06825
gene id: 1454006:AW14_RS06825
uniprot id: A0A0C5W8B1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1454006:AW14 RS11950
gene id: 1454006:AW14_RS11950
uniprot id: A0A0C5WB33
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS04090
gene id: 1454006:AW14_RS04090
uniprot id: A0A0C5VUY8
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

1454006:AW14 RS05805
gene id: 1454006:AW14_RS05805
uniprot id: A0A0C5VW04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1454006:AW14 RS02265
gene id: 1454006:AW14_RS02265
uniprot id: A0A0C5W8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1454006:AW14 RS05320
gene id: 1454006:AW14_RS05320
uniprot id: A0A0C5W7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS01045
gene id: 1454006:AW14_RS01045
uniprot id: A0A0C5WAP5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1454006:AW14 RS11955
gene id: 1454006:AW14_RS11955
uniprot id: A0A0C5WGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1454006:AW14 RS04870
gene id: 1454006:AW14_RS04870
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS07360
gene id: 1454006:AW14_RS07360
uniprot id: A0A0C5W8L1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1454006:AW14 RS01705
gene id: 1454006:AW14_RS01705
uniprot id: A0A0C5WIN4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1454006:AW14 RS04025
gene id: 1454006:AW14_RS04025
uniprot id: A0A0C5W9G5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1454006:AW14 RS04740
gene id: 1454006:AW14_RS04740
uniprot id: A0A0C5WCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

1454006:AW14 RS09765
gene id: 1454006:AW14_RS09765
uniprot id: A0A0C5WFD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1454006:AW14 RS08950
gene id: 1454006:AW14_RS08950
uniprot id: A0A0C5VXF0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1454006:AW14 RS02600
gene id: 1454006:AW14_RS02600
uniprot id: A0A0C5VU82
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS03130
gene id: 1454006:AW14_RS03130
uniprot id: A0A0C5WJA1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1454006:AW14 RS09555
gene id: 1454006:AW14_RS09555
uniprot id: A0A0C5W9Q9
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1454006:AW14 RS02045
gene id: 1454006:AW14_RS02045
uniprot id: A0A0C5WB59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

1454006:AW14 RS00935
gene id: 1454006:AW14_RS00935
uniprot id: A0A0C5W835
names: Similarity
messages: Belongs to the UPF0246 family.

1454006:AW14 RS04475
gene id: 1454006:AW14_RS04475
uniprot id: A0A0C5WJU7
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00270
gene id: 1454006:AW14_RS00270
uniprot id: A0A0C5W5A9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1454006:AW14 RS04550
gene id: 1454006:AW14_RS04550
uniprot id: A0A0C5WCJ0
names: Similarity
messages: Belongs to the YciI family.

1454006:AW14 RS07890
gene id: 1454006:AW14_RS07890
uniprot id: A0A0C5WEE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1454006:AW14 RS07670
gene id: 1454006:AW14_RS07670
uniprot id: A0A0C5WL69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1454006:AW14 RS10600
gene id: 1454006:AW14_RS10600
uniprot id: A0A0C5VYA2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1454006:AW14 RS08880
gene id: 1454006:AW14_RS08880
uniprot id: A0A0C5WBX3
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1454006:AW14 RS10775
gene id: 1454006:AW14_RS10775
uniprot id: A0A0C5WFZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

1454006:AW14 RS01390
gene id: 1454006:AW14_RS01390
uniprot id: A0A0C5W5T1
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

1454006:AW14 RS12870
gene id: 1454006:AW14_RS12870
uniprot id: A0A0C5WDY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS13500
gene id: 1454006:AW14_RS13500
uniprot id: A0A0C5WHC8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1454006:AW14 RS00655
gene id: 1454006:AW14_RS00655
uniprot id: A0A0C5WAJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS09445
gene id: 1454006:AW14_RS09445
uniprot id: A0A0C5WF61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1454006:AW14 RS05130
gene id: 1454006:AW14_RS05130
uniprot id: A0A0C5WA06
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1454006:AW14 RS07065
gene id: 1454006:AW14_RS07065
uniprot id: A0A0C5VWG4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS12690
gene id: 1454006:AW14_RS12690
uniprot id: A0A0C5WDU9
names: Similarity
messages: Belongs to the peptidase C40 family.

1454006:AW14 RS06070
gene id: 1454006:AW14_RS06070
uniprot id: A0A0C5WAI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1454006:AW14 RS00100
gene id: 1454006:AW14_RS00100
uniprot id: A0A0C5VSV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS02000
gene id: 1454006:AW14_RS02000
uniprot id: A0A0C5W8L2
names: Similarity
messages: Belongs to the peptidase M1 family.

1454006:AW14 RS11250
gene id: 1454006:AW14_RS11250
uniprot id: A0A0C5WG83
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1454006:AW14 RS05660
gene id: 1454006:AW14_RS05660
uniprot id: A0A0C5W7Y3
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1454006:AW14 RS13095
gene id: 1454006:AW14_RS13095
uniprot id: A0A0C5WD23
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

1454006:AW14 RS13535
gene id: 1454006:AW14_RS13535
uniprot id: A0A0C5VZV3
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1454006:AW14 RS12455
gene id: 1454006:AW14_RS12455
uniprot id: A0A0C5WBB4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1454006:AW14 RS13085
gene id: 1454006:AW14_RS13085
uniprot id: A0A0C5WBM0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1454006:AW14 RS02930
gene id: 1454006:AW14_RS02930
uniprot id: A0A0C5W6L5
names: Similarity
messages: Belongs to the UPF0102 family.

1454006:AW14 RS10630
gene id: 1454006:AW14_RS10630
uniprot id: A0A0C5WCQ4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
messages: Membrane

1454006:AW14 RS03940
gene id: 1454006:AW14_RS03940
uniprot id: A0A0C5W9F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS05085
gene id: 1454006:AW14_RS05085
uniprot id: A0A0C5W7K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS02310
gene id: 1454006:AW14_RS02310
uniprot id: A0A0C5VU07
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

1454006:AW14 RS03140
gene id: 1454006:AW14_RS03140
uniprot id: A0A0C5W968
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1454006:AW14 RS06860
gene id: 1454006:AW14_RS06860
uniprot id: A0A0C5WKT5
names: Similarity
messages: Belongs to the CinA family.

1454006:AW14 RS02085
gene id: 1454006:AW14_RS02085
uniprot id: A0A0C5W8M9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS12780
gene id: 1454006:AW14_RS12780
uniprot id: A0A0C5WH30
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1454006:AW14 RS02540
gene id: 1454006:AW14_RS02540
uniprot id: A0A0C5WBI0
names: Similarity
messages: Belongs to the SufE family.

1454006:AW14 RS11655
gene id: 1454006:AW14_RS11655
uniprot id: A0A0C5VZ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1454006:AW14 RS02380
gene id: 1454006:AW14_RS02380
uniprot id: A0A0C5W6B5
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1454006:AW14 RS03205
gene id: 1454006:AW14_RS03205
uniprot id: A0A0C5WBU1
names: Subunit
messages: Homodimer.

1454006:AW14 RS03965
gene id: 1454006:AW14_RS03965
uniprot id: A0A0C5W9F6
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

1454006:AW14 RS05140
gene id: 1454006:AW14_RS05140
uniprot id: A0A0C5WD03
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1454006:AW14 RS05060
gene id: 1454006:AW14_RS05060
uniprot id: A0A0C5W7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1454006:AW14 RS00605
gene id: 1454006:AW14_RS00605
uniprot id: A0A0C5W5E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1454006:AW14 RS03320
gene id: 1454006:AW14_RS03320
uniprot id: A0A0C5WBV3
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

1454006:AW14 RS00590
gene id: 1454006:AW14_RS00590
uniprot id: A0A0C5VT30
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1454006:AW14 RS13925
gene id: 1454006:AW14_RS13925
uniprot id: A0A0C5WHI7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1454006:AW14 RS13675
gene id: 1454006:AW14_RS13675
uniprot id: A0A0C5WED0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1454006:AW14 RS04580
gene id: 1454006:AW14_RS04580
uniprot id: A0A0C5WJW9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1454006:AW14 RS10725
gene id: 1454006:AW14_RS10725
uniprot id: A0A0C5WFY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS07945
gene id: 1454006:AW14_RS07945
uniprot id: A0A0C5WEF7
names: Similarity
messages: Belongs to the Dps family.

1454006:AW14 RS07130
gene id: 1454006:AW14_RS07130
uniprot id: A0A0C5WAV9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS05235
gene id: 1454006:AW14_RS05235
uniprot id: A0A0C5WA30
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1454006:AW14 RS09655
gene id: 1454006:AW14_RS09655
uniprot id: A0A0C5W9T0
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1454006:AW14 RS07375
gene id: 1454006:AW14_RS07375
uniprot id: A0A0C5VWL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1454006:AW14 RS08495
gene id: 1454006:AW14_RS08495
uniprot id: A0A0C5WER8
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS11315
gene id: 1454006:AW14_RS11315
uniprot id: A0A0C5WG98
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

1454006:AW14 RS05445
gene id: 1454006:AW14_RS05445
uniprot id: A0A0C5W7S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS09620
gene id: 1454006:AW14_RS09620
uniprot id: A0A0C5VXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1454006:AW14 RS01430
gene id: 1454006:AW14_RS01430
uniprot id: A0A0C5VTH9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1454006:AW14 RS13700
gene id: 1454006:AW14_RS13700
uniprot id: A0A0C5WED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1454006:AW14 RS11765
gene id: 1454006:AW14_RS11765
uniprot id: A0A0C5WDE7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1454006:AW14 RS05790
gene id: 1454006:AW14_RS05790
uniprot id: A0A0C5W7Z6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1454006:AW14 RS04235
gene id: 1454006:AW14_RS04235
uniprot id: A0A0C5WJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1454006:AW14 RS11435
gene id: 1454006:AW14_RS11435
uniprot id: A0A0C5VYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS00795
gene id: 1454006:AW14_RS00795
uniprot id: A0A0C5W816
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS10320
gene id: 1454006:AW14_RS10320
uniprot id: A0A0C5WA54
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1454006:AW14 RS01505
gene id: 1454006:AW14_RS01505
uniprot id: A0A0C5WAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

1454006:AW14 RS13010
gene id: 1454006:AW14_RS13010
uniprot id: A0A0C5VZK3
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

1454006:AW14 RS02035
gene id: 1454006:AW14_RS02035
uniprot id: A0A0C5W649
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1454006:AW14 RS03865
gene id: 1454006:AW14_RS03865
uniprot id: A0A0C5WJJ8
names: Similarity
messages: Belongs to the peptidase S41A family.

1454006:AW14 RS12360
gene id: 1454006:AW14_RS12360
uniprot id: A0A0C5WGU7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1454006:AW14 RS10610
gene id: 1454006:AW14_RS10610
uniprot id: A0A0C5WAB1
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

1454006:AW14 RS00900
gene id: 1454006:AW14_RS00900
uniprot id: A0A0C5VT82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

1454006:AW14 RS06340
gene id: 1454006:AW14_RS06340
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS11650
gene id: 1454006:AW14_RS11650
uniprot id: A0A0C5WN37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1454006:AW14 RS10835
gene id: 1454006:AW14_RS10835
uniprot id: A0A0C5VYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1454006:AW14 RS05715
gene id: 1454006:AW14_RS05715
uniprot id: A0A0C5W7Z1
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1454006:AW14 RS11920
gene id: 1454006:AW14_RS11920
uniprot id: A0A0C5WDG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1454006:AW14 RS11070
gene id: 1454006:AW14_RS11070
uniprot id: A0A0C5WD10
names: Similarity
messages: Belongs to the pirin family.

1454006:AW14 RS01020
gene id: 1454006:AW14_RS01020
uniprot id: A0A0C5WAP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS06760
gene id: 1454006:AW14_RS06760
uniprot id: A0A0C5WKS0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

1454006:AW14 RS06950
gene id: 1454006:AW14_RS06950
uniprot id: A0A0C5WDW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS11970
gene id: 1454006:AW14_RS11970
uniprot id: A0A0C5WDH3
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01185
gene id: 1454006:AW14_RS01185
uniprot id: A0A0C5W868
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1454006:AW14 RS11090
gene id: 1454006:AW14_RS11090
uniprot id: A0A0C5WMQ9
names: Similarity
messages: Belongs to the RutC family.

1454006:AW14 RS03585
gene id: 1454006:AW14_RS03585
uniprot id: A0A0C5WBZ3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1454006:AW14 RS01545
gene id: 1454006:AW14_RS01545
uniprot id: A0A0C5W8C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS09955
gene id: 1454006:AW14_RS09955
uniprot id: A0A0C5WFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS02005
gene id: 1454006:AW14_RS02005
uniprot id: A0A0C5W644
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1454006:AW14 RS02800
gene id: 1454006:AW14_RS02800
uniprot id: A0A0C5WBP9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1454006:AW14 RS03415
gene id: 1454006:AW14_RS03415
uniprot id: A0A0C5WJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1454006:AW14 RS12630
gene id: 1454006:AW14_RS12630
uniprot id: A0A0C5WDT4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS08195
gene id: 1454006:AW14_RS08195
uniprot id: A0A0C5WLF9
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1454006:AW14 RS01100
gene id: 1454006:AW14_RS01100
uniprot id: A0A0C5WIC7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1454006:AW14 RS01080
gene id: 1454006:AW14_RS01080
uniprot id: A0A0C5VTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1454006:AW14 RS01685
gene id: 1454006:AW14_RS01685
uniprot id: A0A0C5W8F7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1454006:AW14 RS12245
gene id: 1454006:AW14_RS12245
uniprot id: A0A0C5WNA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1454006:AW14 RS08270
gene id: 1454006:AW14_RS08270
uniprot id: A0A0C5WEN0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1454006:AW14 RS00860
gene id: 1454006:AW14_RS00860
uniprot id: A0A0C5W5I3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03395
gene id: 1454006:AW14_RS03395
uniprot id: A0A0C5W996
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS06690
gene id: 1454006:AW14_RS06690
uniprot id: A0A0C5WKR4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1454006:AW14 RS10345
gene id: 1454006:AW14_RS10345
uniprot id: A0A0C5WA59
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1454006:AW14 RS00105
gene id: 1454006:AW14_RS00105
uniprot id: A0A0C5W7V0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01370
gene id: 1454006:AW14_RS01370
uniprot id: A0A0C5WAU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1454006:AW14 RS09640
gene id: 1454006:AW14_RS09640
uniprot id: A0A0C5WM24
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1454006:AW14 RS09345
gene id: 1454006:AW14_RS09345
uniprot id: A0A0C5WLY4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1454006:AW14 RS03995
gene id: 1454006:AW14_RS03995
uniprot id: A0A0C5VUX2
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1454006:AW14 RS12825
gene id: 1454006:AW14_RS12825
uniprot id: A0A0C5VZG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS09125
gene id: 1454006:AW14_RS09125
uniprot id: A0A0C5VXH4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02665
gene id: 1454006:AW14_RS02665
uniprot id: A0A0C5WBL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1454006:AW14 RS11020
gene id: 1454006:AW14_RS11020
uniprot id: A0A0C5WCZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1454006:AW14 RS00645
gene id: 1454006:AW14_RS00645
uniprot id: A0A0C5W7Z7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1454006:AW14 RS12535
gene id: 1454006:AW14_RS12535
uniprot id: A0A0C5WGY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1454006:AW14 RS07415
gene id: 1454006:AW14_RS07415
uniprot id: A0A0C5WE69
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS05040
gene id: 1454006:AW14_RS05040
uniprot id: A0A0C5WK50
names: Similarity
messages: Belongs to the asparaginase 1 family.

1454006:AW14 RS00380
gene id: 1454006:AW14_RS00380
uniprot id: A0A0C5WAF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS08520
gene id: 1454006:AW14_RS08520
uniprot id: A0A0C5WES1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1454006:AW14 RS12880
gene id: 1454006:AW14_RS12880
uniprot id: A0A0C5WH43
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS01105
gene id: 1454006:AW14_RS01105
uniprot id: A0A0C5VTC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1454006:AW14 RS03255
gene id: 1454006:AW14_RS03255
uniprot id: A0A0C5W980
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1454006:AW14 RS03405
gene id: 1454006:AW14_RS03405
uniprot id: A0A0C5W6Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1454006:AW14 RS03570
gene id: 1454006:AW14_RS03570
uniprot id: A0A0C5W0I0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04435
gene id: 1454006:AW14_RS04435
uniprot id: A0A0C5WCF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1454006:AW14 RS01055
gene id: 1454006:AW14_RS01055
uniprot id: A0A0C5VTB1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1454006:AW14 RS10940
gene id: 1454006:AW14_RS10940
uniprot id: A0A0C5WAJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1454006:AW14 RS11660
gene id: 1454006:AW14_RS11660
uniprot id: A0A0C5WDD8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1454006:AW14 RS05080
gene id: 1454006:AW14_RS05080
uniprot id: A0A0C5W9Z6
names: Similarity
messages: Belongs to the sigma-54 factor family.

1454006:AW14 RS06015
gene id: 1454006:AW14_RS06015
uniprot id: A0A0C5VW29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1454006:AW14 RS01330
gene id: 1454006:AW14_RS01330
uniprot id: A0A0C5VTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS00365
gene id: 1454006:AW14_RS00365
uniprot id: A0A0C5VSZ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS12850
gene id: 1454006:AW14_RS12850
uniprot id: A0A0C5WNJ2
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS02375
gene id: 1454006:AW14_RS02375
uniprot id: A0A0C5W8U2
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS05225
gene id: 1454006:AW14_RS05225
uniprot id: A0A0C5WK88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1454006:AW14 RS03735
gene id: 1454006:AW14_RS03735
uniprot id: A0A0C5WJH4
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1454006:AW14 RS11665
gene id: 1454006:AW14_RS11665
uniprot id: A0A0C5WAZ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01935
gene id: 1454006:AW14_RS01935
uniprot id: A0A0C5W633
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1454006:AW14 RS06195
gene id: 1454006:AW14_RS06195
uniprot id: A0A0C5WKM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01535
gene id: 1454006:AW14_RS01535
uniprot id: A0A0C5WIK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS10025
gene id: 1454006:AW14_RS10025
uniprot id: A0A0C5W9Z9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1454006:AW14 RS01435
gene id: 1454006:AW14_RS01435
uniprot id: A0A0C5W8A3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1454006:AW14 RS12520
gene id: 1454006:AW14_RS12520
uniprot id: A0A0C5VZA3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1454006:AW14 RS11595
gene id: 1454006:AW14_RS11595
uniprot id: A0A0C5VZ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1454006:AW14 RS11575
gene id: 1454006:AW14_RS11575
uniprot id: A0A0C5WDD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1454006:AW14 RS09890
gene id: 1454006:AW14_RS09890
uniprot id: A0A0C5WC96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS01160
gene id: 1454006:AW14_RS01160
uniprot id: A0A0C5W865
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1454006:AW14 RS02750
gene id: 1454006:AW14_RS02750
uniprot id: A0A0C5WJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS04095
gene id: 1454006:AW14_RS04095
uniprot id: A0A0C5W9H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS04425
gene id: 1454006:AW14_RS04425
uniprot id: A0A0C5W9L1
names: Similarity
messages: Belongs to the peptidase M16 family.

1454006:AW14 RS05485
gene id: 1454006:AW14_RS05485
uniprot id: A0A0C5VVT5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1454006:AW14 RS01175
gene id: 1454006:AW14_RS01175
uniprot id: A0A0C5WIE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1454006:AW14 RS05800
gene id: 1454006:AW14_RS05800
uniprot id: A0A0C5WKI0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1454006:AW14 RS07905
gene id: 1454006:AW14_RS07905
uniprot id: A0A0C5WB96
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1454006:AW14 RS11760
gene id: 1454006:AW14_RS11760
uniprot id: A0A0C5WD08
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS03420
gene id: 1454006:AW14_RS03420
uniprot id: A0A0C5VUN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1454006:AW14 RS10100
gene id: 1454006:AW14_RS10100
uniprot id: A0A0C5WM87
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS07840
gene id: 1454006:AW14_RS07840
uniprot id: A0A0C5WL91
names: Similarity
messages: Belongs to the AAA ATPase family.

1454006:AW14 RS01090
gene id: 1454006:AW14_RS01090
uniprot id: A0A0C5W5M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1454006:AW14 RS06385
gene id: 1454006:AW14_RS06385
uniprot id: A0A0C5WAM6
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02840
gene id: 1454006:AW14_RS02840
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS02725
gene id: 1454006:AW14_RS02725
uniprot id: A0A0C5WJ70
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1454006:AW14 RS05250
gene id: 1454006:AW14_RS05250
uniprot id: A0A0C5WK93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS10405
gene id: 1454006:AW14_RS10405
uniprot id: A0A0C5WMC6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS07520
gene id: 1454006:AW14_RS07520
uniprot id: A0A0C5W8N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1454006:AW14 RS09070
gene id: 1454006:AW14_RS09070
uniprot id: A0A0C5W9J1
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS04795
gene id: 1454006:AW14_RS04795
uniprot id: A0A0C5WCQ2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1454006:AW14 RS00805
gene id: 1454006:AW14_RS00805
uniprot id: A0A0C5WAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1454006:AW14 RS08750
gene id: 1454006:AW14_RS08750
uniprot id: A0A0C5WLR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1454006:AW14 RS00660
gene id: 1454006:AW14_RS00660
uniprot id: A0A0C5WI49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1454006:AW14 RS04750
gene id: 1454006:AW14_RS04750
uniprot id: A0A0C5VVB2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1454006:AW14 RS12700
gene id: 1454006:AW14_RS12700
uniprot id: A0A0C5WH15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1454006:AW14 RS02210
gene id: 1454006:AW14_RS02210
uniprot id: A0A0C5VTY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS13680
gene id: 1454006:AW14_RS13680
uniprot id: A0A0C5WBW6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1454006:AW14 RS00200
gene id: 1454006:AW14_RS00200
uniprot id: A0A0C5VSW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1454006:AW14 RS09915
gene id: 1454006:AW14_RS09915
uniprot id: A0A0C5WC99
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1454006:AW14 RS03530
gene id: 1454006:AW14_RS03530
uniprot id: A0A0C5W9B0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1454006:AW14 RS06250
gene id: 1454006:AW14_RS06250
uniprot id: A0A0C5WDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1454006:AW14 RS02050
gene id: 1454006:AW14_RS02050
uniprot id: A0A0C5WIT5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1454006:AW14 RS00560
gene id: 1454006:AW14_RS00560
uniprot id: A0A0C5WI34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1454006:AW14 RS08375
gene id: 1454006:AW14_RS08375
uniprot id: A0A0C5W955
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1454006:AW14 RS08210
gene id: 1454006:AW14_RS08210
uniprot id: A0A0C5WBG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1454006:AW14 RS03180
gene id: 1454006:AW14_RS03180
uniprot id: A0A0C5WBT6
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04150
gene id: 1454006:AW14_RS04150
uniprot id: A0A0C5W9I2
names: Similarity
messages: Belongs to the aspartokinase family.

1454006:AW14 RS00350
gene id: 1454006:AW14_RS00350
uniprot id: A0A0C5W5B6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1454006:AW14 RS09720
gene id: 1454006:AW14_RS09720
uniprot id: A0A0C5VXR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1454006:AW14 RS01220
gene id: 1454006:AW14_RS01220
uniprot id: A0A0C5WP77
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS03265
gene id: 1454006:AW14_RS03265
uniprot id: A0A0C5WBU8
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1454006:AW14 RS12430
gene id: 1454006:AW14_RS12430
uniprot id: A0A0C5WBA7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1454006:AW14 RS13345
gene id: 1454006:AW14_RS13345
uniprot id: A0A0C5VZQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS12445
gene id: 1454006:AW14_RS12445
uniprot id: A0A0C5WND2
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS12545
gene id: 1454006:AW14_RS12545
uniprot id: A0A0C5VZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1454006:AW14 RS00080
gene id: 1454006:AW14_RS00080
uniprot id: A0A0C5W7U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1454006:AW14 RS02485
gene id: 1454006:AW14_RS02485
uniprot id: A0A0C5WBG8
names: Similarity
messages: Belongs to the aspartokinase family.

1454006:AW14 RS08165
gene id: 1454006:AW14_RS08165
uniprot id: A0A0C5WLF5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS00550
gene id: 1454006:AW14_RS00550
uniprot id: A0A0C5W5D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1454006:AW14 RS07355
gene id: 1454006:AW14_RS07355
uniprot id: A0A0C5WAY9
names: Similarity
messages: Belongs to the DEAD box helicase family.

1454006:AW14 RS03960
gene id: 1454006:AW14_RS03960
uniprot id: A0A0C5VUW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1454006:AW14 RS13070
gene id: 1454006:AW14_RS13070
uniprot id: A0A0C5WNM1
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS00330
gene id: 1454006:AW14_RS00330
uniprot id: A0A0C5WAE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1454006:AW14 RS12615
gene id: 1454006:AW14_RS12615
uniprot id: A0A0C5WH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

1454006:AW14 RS02885
gene id: 1454006:AW14_RS02885
uniprot id: A0A0C5W6L1
names: Similarity
messages: Belongs to the SCO1/2 family.

1454006:AW14 RS05170
gene id: 1454006:AW14_RS05170
uniprot id: A0A0C5WD09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1454006:AW14 RS01780
gene id: 1454006:AW14_RS01780
uniprot id: A0A0C5W607
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1454006:AW14 RS05105
gene id: 1454006:AW14_RS05105
uniprot id: A0A0C5WA01
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS04715
gene id: 1454006:AW14_RS04715
uniprot id: A0A0C5VVA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1454006:AW14 RS01805
gene id: 1454006:AW14_RS01805
uniprot id: A0A0C5W613
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1454006:AW14 RS05615
gene id: 1454006:AW14_RS05615
uniprot id: A0A0C5WDB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

1454006:AW14 RS05120
gene id: 1454006:AW14_RS05120
uniprot id: A0A0C5WK67
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1454006:AW14 RS02760
gene id: 1454006:AW14_RS02760
uniprot id: A0A0C5W932
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

1454006:AW14 RS11080
gene id: 1454006:AW14_RS11080
uniprot id: A0A0C5WG48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

1454006:AW14 RS10815
gene id: 1454006:AW14_RS10815
uniprot id: A0A0C5WCV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1454006:AW14 RS09240
gene id: 1454006:AW14_RS09240
uniprot id: A0A0C5WLW6
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS06245
gene id: 1454006:AW14_RS06245
uniprot id: A0A0C5W854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1454006:AW14 RS10280
gene id: 1454006:AW14_RS10280
uniprot id: A0A0C5WMA7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1454006:AW14 RS05750
gene id: 1454006:AW14_RS05750
uniprot id: A0A0C5WAE3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

1454006:AW14 RS07475
gene id: 1454006:AW14_RS07475
uniprot id: A0A0C5WE78
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS06030
gene id: 1454006:AW14_RS06030
uniprot id: A0A0C5WDI9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS05635
gene id: 1454006:AW14_RS05635
uniprot id: A0A0C5W7W4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1454006:AW14 RS09975
gene id: 1454006:AW14_RS09975
uniprot id: A0A0C5W9Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1454006:AW14 RS13440
gene id: 1454006:AW14_RS13440
uniprot id: A0A0C5WBR9
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1454006:AW14 RS04840
gene id: 1454006:AW14_RS04840
uniprot id: A0A0C5W9U2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1454006:AW14 RS09255
gene id: 1454006:AW14_RS09255
uniprot id: A0A0C5W9L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1454006:AW14 RS05840
gene id: 1454006:AW14_RS05840
uniprot id: A0A0C5W802
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1454006:AW14 RS04760
gene id: 1454006:AW14_RS04760
uniprot id: A0A0C5W7E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1454006:AW14 RS03820
gene id: 1454006:AW14_RS03820
uniprot id: A0A0C5VUU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS00150
gene id: 1454006:AW14_RS00150
uniprot id: A0A0C5VSW1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1454006:AW14 RS03425
gene id: 1454006:AW14_RS03425
uniprot id: A0A0C5W999
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

1454006:AW14 RS01730
gene id: 1454006:AW14_RS01730
uniprot id: A0A0C5WIN7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1454006:AW14 RS11355
gene id: 1454006:AW14_RS11355
uniprot id: A0A0C5WMX6
names: Similarity
messages: Belongs to the SUI1 family.

1454006:AW14 RS04005
gene id: 1454006:AW14_RS04005
uniprot id: A0A0C5W6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS11670
gene id: 1454006:AW14_RS11670
uniprot id: A0A0C5WGJ0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1454006:AW14 RS02055
gene id: 1454006:AW14_RS02055
uniprot id: A0A0C5VTU2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1454006:AW14 RS09270
gene id: 1454006:AW14_RS09270
uniprot id: A0A0C5VXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1454006:AW14 RS04585
gene id: 1454006:AW14_RS04585
uniprot id: A0A0C5VV76
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1454006:AW14 RS01265
gene id: 1454006:AW14_RS01265
uniprot id: A0A0C5VTF0
names: Similarity
messages: Belongs to the UPF0758 family.

1454006:AW14 RS00700
gene id: 1454006:AW14_RS00700
uniprot id: A0A0C5W5G0
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS04105
gene id: 1454006:AW14_RS04105
uniprot id: A0A0C5WC87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS05360
gene id: 1454006:AW14_RS05360
uniprot id: A0A0C5VVQ4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS03655
gene id: 1454006:AW14_RS03655
uniprot id: A0A0C5VUS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS10060
gene id: 1454006:AW14_RS10060
uniprot id: A0A0C5WA03
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1454006:AW14 RS14100
gene id: 1454006:AW14_RS14100
uniprot id: A0A0C5WHM0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1454006:AW14 RS08250
gene id: 1454006:AW14_RS08250
uniprot id: A0A0C5WLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1454006:AW14 RS06810
gene id: 1454006:AW14_RS06810
uniprot id: A0A0C5WKS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1454006:AW14 RS04890
gene id: 1454006:AW14_RS04890
uniprot id: A0A0C5VVD9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03750
gene id: 1454006:AW14_RS03750
uniprot id: A0A0C5W9D5
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

1454006:AW14 RS01135
gene id: 1454006:AW14_RS01135
uniprot id: A0A0C5W862
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1454006:AW14 RS04135
gene id: 1454006:AW14_RS04135
uniprot id: A0A0C5WC94
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1454006:AW14 RS09185
gene id: 1454006:AW14_RS09185
uniprot id: A0A0C5VXI2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1454006:AW14 RS08015
gene id: 1454006:AW14_RS08015
uniprot id: A0A0C5WBC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1454006:AW14 RS06075
gene id: 1454006:AW14_RS06075
uniprot id: A0A0C5W829
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1454006:AW14 RS12060
gene id: 1454006:AW14_RS12060
uniprot id: A0A0C5WGQ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1454006:AW14 RS05935
gene id: 1454006:AW14_RS05935
uniprot id: A0A0C5VW21
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1454006:AW14 RS09965
gene id: 1454006:AW14_RS09965
uniprot id: A0A0C5VXV9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1454006:AW14 RS05290
gene id: 1454006:AW14_RS05290
uniprot id: A0A0C5WA41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1454006:AW14 RS08220
gene id: 1454006:AW14_RS08220
uniprot id: A0A0C5WEL9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS01125
gene id: 1454006:AW14_RS01125
uniprot id: A0A0C5WID2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1454006:AW14 RS02525
gene id: 1454006:AW14_RS02525
uniprot id: A0A0C5W8W9
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1454006:AW14 RS00910
gene id: 1454006:AW14_RS00910
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS02925
gene id: 1454006:AW14_RS02925
uniprot id: A0A0C5W952
names: Similarity
messages: Belongs to the DtxR/MntR family.

1454006:AW14 RS05405
gene id: 1454006:AW14_RS05405
uniprot id: A0A0C5WKC0
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1454006:AW14 RS05970
gene id: 1454006:AW14_RS05970
uniprot id: A0A0C5W819
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1454006:AW14 RS04955
gene id: 1454006:AW14_RS04955
uniprot id: A0A0C5WCV2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1454006:AW14 RS03890
gene id: 1454006:AW14_RS03890
uniprot id: A0A0C5WC55
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS01795
gene id: 1454006:AW14_RS01795
uniprot id: A0A0C5VTP9
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1454006:AW14 RS13470
gene id: 1454006:AW14_RS13470
uniprot id: A0A0C5WHC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1454006:AW14 RS07465
gene id: 1454006:AW14_RS07465
uniprot id: A0A0C5WB08
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1454006:AW14 RS12370
gene id: 1454006:AW14_RS12370
uniprot id: A0A0C5VZ81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1454006:AW14 RS00585
gene id: 1454006:AW14_RS00585
uniprot id: A0A0C5WI39
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1454006:AW14 RS11210
gene id: 1454006:AW14_RS11210
uniprot id: A0A0C5WD48
names: Similarity
messages: Belongs to the peptidase M1 family.

1454006:AW14 RS00995
gene id: 1454006:AW14_RS00995
uniprot id: A0A0C5WAN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1454006:AW14 RS10340
gene id: 1454006:AW14_RS10340
uniprot id: A0A0C5WCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS13980
gene id: 1454006:AW14_RS13980
uniprot id: A0A0C5WEJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1454006:AW14 RS02230
gene id: 1454006:AW14_RS02230
uniprot id: A0A0C5WIX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS08705
gene id: 1454006:AW14_RS08705
uniprot id: A0A0C5WPP0
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1454006:AW14 RS05135
gene id: 1454006:AW14_RS05135
uniprot id: A0A0C5W7L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1454006:AW14 RS00165
gene id: 1454006:AW14_RS00165
uniprot id: A0A0C5WAD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1454006:AW14 RS02790
gene id: 1454006:AW14_RS02790
uniprot id: A0A0C5W937
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1454006:AW14 RS12705
gene id: 1454006:AW14_RS12705
uniprot id: A0A0C5WNH1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1454006:AW14 RS09610
gene id: 1454006:AW14_RS09610
uniprot id: A0A0C5WF98
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1454006:AW14 RS13575
gene id: 1454006:AW14_RS13575
uniprot id: A0A0C5WHE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS03895
gene id: 1454006:AW14_RS03895
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS04300
gene id: 1454006:AW14_RS04300
uniprot id: A0A0C5VV23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1454006:AW14 RS13530
gene id: 1454006:AW14_RS13530
uniprot id: A0A0C5WNS3
names: Similarity
messages: Belongs to the IMPACT family.

1454006:AW14 RS12890
gene id: 1454006:AW14_RS12890
uniprot id: A0A0C5VZI1
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS04595
gene id: 1454006:AW14_RS04595
uniprot id: A0A0C5W7A6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

1454006:AW14 RS07205
gene id: 1454006:AW14_RS07205
uniprot id: A0A0C5WE22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

1454006:AW14 RS06010
gene id: 1454006:AW14_RS06010
uniprot id: A0A0C5WKK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1454006:AW14 RS11170
gene id: 1454006:AW14_RS11170
uniprot id: A0A0C5WMS8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1454006:AW14 RS00120
gene id: 1454006:AW14_RS00120
uniprot id: A0A0C5WHX5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS07345
gene id: 1454006:AW14_RS07345
uniprot id: A0A0C5WL09
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS06345
gene id: 1454006:AW14_RS06345
uniprot id: A0A0C5WAM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

1454006:AW14 RS10595
gene id: 1454006:AW14_RS10595
uniprot id: A0A0C5WMF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1454006:AW14 RS08710
gene id: 1454006:AW14_RS08710
uniprot id: A0A0C5WBT1
names: Similarity
messages: Belongs to the sulfatase family.

1454006:AW14 RS14105
gene id: 1454006:AW14_RS14105
uniprot id: A0A0C5WP19
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1454006:AW14 RS08255
gene id: 1454006:AW14_RS08255
uniprot id: A0A0C5VX10
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1454006:AW14 RS04695
gene id: 1454006:AW14_RS04695
uniprot id: A0A0C5W9R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1454006:AW14 RS08290
gene id: 1454006:AW14_RS08290
uniprot id: A0A0C5WBJ2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS00945
gene id: 1454006:AW14_RS00945
uniprot id: A0A0C5WAM9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1454006:AW14 RS05710
gene id: 1454006:AW14_RS05710
uniprot id: A0A0C5WAD8
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1454006:AW14 RS08575
gene id: 1454006:AW14_RS08575
uniprot id: A0A0C5WET1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

1454006:AW14 RS01550
gene id: 1454006:AW14_RS01550
uniprot id: A0A0C5W5W3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1454006:AW14 RS11635
gene id: 1454006:AW14_RS11635
uniprot id: A0A0C5WDD5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

1454006:AW14 RS05175
gene id: 1454006:AW14_RS05175
uniprot id: A0A0C5WK78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1454006:AW14 RS03430
gene id: 1454006:AW14_RS03430
uniprot id: A0A0C5W6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1454006:AW14 RS02895
gene id: 1454006:AW14_RS02895
uniprot id: A0A0C5WJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

1454006:AW14 RS01115
gene id: 1454006:AW14_RS01115
uniprot id: A0A0C5W5M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1454006:AW14 RS02710
gene id: 1454006:AW14_RS02710
uniprot id: A0A0C5W912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS09330
gene id: 1454006:AW14_RS09330
uniprot id: A0A0C5W9M4
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS02115
gene id: 1454006:AW14_RS02115
uniprot id: A0A0C5W664
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS04800
gene id: 1454006:AW14_RS04800
uniprot id: A0A0C5WK06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1454006:AW14 RS05180
gene id: 1454006:AW14_RS05180
uniprot id: A0A0C5VVK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1454006:AW14 RS08425
gene id: 1454006:AW14_RS08425
uniprot id: A0A0C5VX48
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1454006:AW14 RS11205
gene id: 1454006:AW14_RS11205
uniprot id: A0A0C5WCZ5
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1454006:AW14 RS11925
gene id: 1454006:AW14_RS11925
uniprot id: A0A0C5WB29
names: Similarity
messages: Belongs to the threonine aldolase family.

1454006:AW14 RS12450
gene id: 1454006:AW14_RS12450
uniprot id: A0A0C5WDP7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1454006:AW14 RS01040
gene id: 1454006:AW14_RS01040
uniprot id: A0A0C5W5L3
names: Similarity
messages: Belongs to the citrate synthase family.

1454006:AW14 RS06270
gene id: 1454006:AW14_RS06270
uniprot id: A0A0C5W859
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS10140
gene id: 1454006:AW14_RS10140
uniprot id: A0A0C5WA19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11165
gene id: 1454006:AW14_RS11165
uniprot id: A0A0C5WG63
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1454006:AW14 RS09020
gene id: 1454006:AW14_RS09020
uniprot id: A0A0C5W9I5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS13710
gene id: 1454006:AW14_RS13710
uniprot id: A0A0C5WHF9
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS08245
gene id: 1454006:AW14_RS08245
uniprot id: A0A0C5WEM4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1454006:AW14 RS02205
gene id: 1454006:AW14_RS02205
uniprot id: A0A0C5WIW4
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1454006:AW14 RS11545
gene id: 1454006:AW14_RS11545
uniprot id: A0A0C5WIF2
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS10380
gene id: 1454006:AW14_RS10380
uniprot id: A0A0C5WMC1
names: Similarity
messages: Belongs to the BshC family.

1454006:AW14 RS04665
gene id: 1454006:AW14_RS04665
uniprot id: A0A0C5VV94
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1454006:AW14 RS10510
gene id: 1454006:AW14_RS10510
uniprot id: A0A0C5WFU0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1454006:AW14 RS06970
gene id: 1454006:AW14_RS06970
uniprot id: A0A0C5W8D9
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00250
gene id: 1454006:AW14_RS00250
uniprot id: A0A0C5VSY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS05855
gene id: 1454006:AW14_RS05855
uniprot id: A0A0C5VW11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS01725
gene id: 1454006:AW14_RS01725
uniprot id: A0A0C5WAZ7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1454006:AW14 RS10545
gene id: 1454006:AW14_RS10545
uniprot id: A0A0C5VY86
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1454006:AW14 RS12305
gene id: 1454006:AW14_RS12305
uniprot id: A0A0C5WNB1
names: Similarity
messages: Belongs to the CvfB family.

1454006:AW14 RS04705
gene id: 1454006:AW14_RS04705
uniprot id: A0A0C5WCM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS11600
gene id: 1454006:AW14_RS11600
uniprot id: A0A0C5WDD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1454006:AW14 RS01680
gene id: 1454006:AW14_RS01680
uniprot id: A0A0C5VTM9
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1454006:AW14 RS04835
gene id: 1454006:AW14_RS04835
uniprot id: A0A0C5VVC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1454006:AW14 RS13605
gene id: 1454006:AW14_RS13605
uniprot id: A0A0C5WNT5
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1454006:AW14 RS01130
gene id: 1454006:AW14_RS01130
uniprot id: A0A0C5VTC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1454006:AW14 RS02330
gene id: 1454006:AW14_RS02330
uniprot id: A0A0C5WIZ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).

1454006:AW14 RS01500
gene id: 1454006:AW14_RS01500
uniprot id: A0A0C5W5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1454006:AW14 RS07075
gene id: 1454006:AW14_RS07075
uniprot id: A0A0C5W8G0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1454006:AW14 RS02465
gene id: 1454006:AW14_RS02465
uniprot id: A0A0C5WJ05
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1454006:AW14 RS11590
gene id: 1454006:AW14_RS11590
uniprot id: A0A0C5WN31
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1454006:AW14 RS08205
gene id: 1454006:AW14_RS08205
uniprot id: A0A0C5VWZ8
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1454006:AW14 RS01800
gene id: 1454006:AW14_RS01800
uniprot id: A0A0C5W8I0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1454006:AW14 RS11225
gene id: 1454006:AW14_RS11225
uniprot id: A0A0C5WMU5
names: Similarity
messages: Belongs to the glutamate synthase family.

1454006:AW14 RS04450
gene id: 1454006:AW14_RS04450
uniprot id: A0A0C5VV44
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

1454006:AW14 RS08865
gene id: 1454006:AW14_RS08865
uniprot id: A0A0C5WEX9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1454006:AW14 RS04895
gene id: 1454006:AW14_RS04895
uniprot id: A0A0C5W9V3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1454006:AW14 RS06175
gene id: 1454006:AW14_RS06175
uniprot id: A0A0C5VW57
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS01165
gene id: 1454006:AW14_RS01165
uniprot id: A0A0C5W5N8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1454006:AW14 RS02385
gene id: 1454006:AW14_RS02385
uniprot id: A0A0C5WBE7
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1454006:AW14 RS00095
gene id: 1454006:AW14_RS00095
uniprot id: A0A0C5WHX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1454006:AW14 RS04225
gene id: 1454006:AW14_RS04225
uniprot id: A0A0C5W732
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1454006:AW14 RS06215
gene id: 1454006:AW14_RS06215
uniprot id: A0A0C5W849
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1454006:AW14 RS03925
gene id: 1454006:AW14_RS03925
uniprot id: A0A0C5WC59
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1454006:AW14 RS08485
gene id: 1454006:AW14_RS08485
uniprot id: A0A0C5WBN5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1454006:AW14 RS01050
gene id: 1454006:AW14_RS01050
uniprot id: A0A0C5WIB6
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1454006:AW14 RS08025
gene id: 1454006:AW14_RS08025
uniprot id: A0A0C5WEH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

1454006:AW14 RS01655
gene id: 1454006:AW14_RS01655
uniprot id: A0A0C5W5Y6
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

1454006:AW14 RS06955
gene id: 1454006:AW14_RS06955
uniprot id: A0A0C5WKU5
names: Similarity
messages: Belongs to the universal stress protein A family.

1454006:AW14 RS08065
gene id: 1454006:AW14_RS08065
uniprot id: A0A0C5WBD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1454006:AW14 RS09315
gene id: 1454006:AW14_RS09315
uniprot id: A0A0C5WLX9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1454006:AW14 RS08860
gene id: 1454006:AW14_RS08860
uniprot id: A0A0C5W9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1454006:AW14 RS04480
gene id: 1454006:AW14_RS04480
uniprot id: A0A0C5VV52
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

1454006:AW14 RS11945
gene id: 1454006:AW14_RS11945
uniprot id: A0A0C5WDG9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1454006:AW14 RS05375
gene id: 1454006:AW14_RS05375
uniprot id: A0A0C5WD66
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1454006:AW14 RS04255
gene id: 1454006:AW14_RS04255
uniprot id: A0A0C5W739
names: Similarity
messages: Belongs to the RelE toxin family.

1454006:AW14 RS03685
gene id: 1454006:AW14_RS03685
uniprot id: A0A0C5W9C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1454006:AW14 RS12760
gene id: 1454006:AW14_RS12760
uniprot id: A0A0C5VZF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1454006:AW14 RS06555
gene id: 1454006:AW14_RS06555
uniprot id: A0A0C5W882
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

1454006:AW14 RS07935
gene id: 1454006:AW14_RS07935
uniprot id: A0A0C5W8V6
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS08470
gene id: 1454006:AW14_RS08470
uniprot id: A0A0C5WLL3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1454006:AW14 RS10020
gene id: 1454006:AW14_RS10020
uniprot id: A0A0C5WCB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

1454006:AW14 RS06425
gene id: 1454006:AW14_RS06425
uniprot id: A0A0C5WJ83
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1454006:AW14 RS03100
gene id: 1454006:AW14_RS03100
uniprot id: A0A0C5WJ99
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

1454006:AW14 RS05415
gene id: 1454006:AW14_RS05415
uniprot id: A0A0C5WA69
names: Similarity
messages: Belongs to the Skp family.

1454006:AW14 RS02690
gene id: 1454006:AW14_RS02690
uniprot id: A0A0C5WBL7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1454006:AW14 RS07435
gene id: 1454006:AW14_RS07435
uniprot id: A0A0C5WB02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1454006:AW14 RS11380
gene id: 1454006:AW14_RS11380
uniprot id: A0A0C5WMY2
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1454006:AW14 RS03640
gene id: 1454006:AW14_RS03640
uniprot id: A0A0C5W6U2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1454006:AW14 RS10520
gene id: 1454006:AW14_RS10520
uniprot id: A0A0C5VY79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1454006:AW14 RS01205
gene id: 1454006:AW14_RS01205
uniprot id: A0A0C5VTE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1454006:AW14 RS12820
gene id: 1454006:AW14_RS12820
uniprot id: A0A0C5WNI7
names: Similarity
messages: Belongs to the SusD family.

1454006:AW14 RS07540
gene id: 1454006:AW14_RS07540
uniprot id: A0A0C5WB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1454006:AW14 RS10125
gene id: 1454006:AW14_RS10125
uniprot id: A0A0C5WM89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

1454006:AW14 RS12745
gene id: 1454006:AW14_RS12745
uniprot id: A0A0C5WBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1454006:AW14 RS03200
gene id: 1454006:AW14_RS03200
uniprot id: A0A0C5W6N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1454006:AW14 RS09035
gene id: 1454006:AW14_RS09035
uniprot id: A0A0C5VXG3
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1454006:AW14 RS13995
gene id: 1454006:AW14_RS13995
uniprot id: A0A0C5WNZ9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1454006:AW14 RS14065
gene id: 1454006:AW14_RS14065
uniprot id: A0A0C5WC63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1454006:AW14 RS13105
gene id: 1454006:AW14_RS13105
uniprot id: A0A0C5VZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1454006:AW14 RS11560
gene id: 1454006:AW14_RS11560
uniprot id: A0A0C5WN24
names: Subcellular Location Annotation
messages: Membrane

1454006:AW14 RS00450
gene id: 1454006:AW14_RS00450
uniprot id: A0A0C5VT10
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1454006:AW14 RS09175
gene id: 1454006:AW14_RS09175
uniprot id: A0A0C5WF20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.