145261:N5910 RS06120
gene id: 145261:N5910_RS06120
uniprot id: A0A9E7RRG6
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

145261:N5910 RS01145
gene id: 145261:N5910_RS01145
uniprot id: A0A9E7ULZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

145261:N5910 RS07745
gene id: 145261:N5910_RS07745
uniprot id: A0A9E7RVT7
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

145261:N5910 RS01040
gene id: 145261:N5910_RS01040
uniprot id: A0A9E7RUL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

145261:N5910 RS09130
gene id: 145261:N5910_RS09130
uniprot id: A0A9E7RUR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS05015
gene id: 145261:N5910_RS05015
uniprot id: A0A9E7RT98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

145261:N5910 RS06905
gene id: 145261:N5910_RS06905
uniprot id: A0A9E7UG32
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

145261:N5910 RS04275
gene id: 145261:N5910_RS04275
uniprot id: A0A9E7RVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

145261:N5910 RS06785
gene id: 145261:N5910_RS06785
uniprot id: A0A9E7RTU2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

145261:N5910 RS07810
gene id: 145261:N5910_RS07810
uniprot id: A0A9E7RSH0
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01030
gene id: 145261:N5910_RS01030
uniprot id: A0A9E7RV81
names: Similarity
messages: Belongs to the HupF/HypC family.

145261:N5910 RS08500
gene id: 145261:N5910_RS08500
uniprot id: A0A9E7RUE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

145261:N5910 RS09255
gene id: 145261:N5910_RS09255
uniprot id: A0A9E7ULQ8
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

145261:N5910 RS06860
gene id: 145261:N5910_RS06860
uniprot id: A0A9E7RW14
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

145261:N5910 RS08820
gene id: 145261:N5910_RS08820
uniprot id: A0A9E7RTL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS07820
gene id: 145261:N5910_RS07820
uniprot id: A0A9E7RU96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS08380
gene id: 145261:N5910_RS08380
uniprot id: A0A9E7UGG9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS02245
gene id: 145261:N5910_RS02245
uniprot id: A0A9E7UM61
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS07155
gene id: 145261:N5910_RS07155
uniprot id: A0A9E7RS68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

145261:N5910 RS08690
gene id: 145261:N5910_RS08690
uniprot id: A0A9E7RSU1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

145261:N5910 RS03095
gene id: 145261:N5910_RS03095
uniprot id: A0A9E7RU57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

145261:N5910 RS05890
gene id: 145261:N5910_RS05890
uniprot id: A0A9E7RTJ8
names: Similarity
messages: Belongs to the UPF0047 family.

145261:N5910 RS05515
gene id: 145261:N5910_RS05515
uniprot id: A0A9E7RSB6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

145261:N5910 RS00915
gene id: 145261:N5910_RS00915
uniprot id: A0A9E7ULX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

145261:N5910 RS03000
gene id: 145261:N5910_RS03000
uniprot id: A0A9E7UNC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

145261:N5910 RS02880
gene id: 145261:N5910_RS02880
uniprot id: A0A9E7RVC5
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

145261:N5910 RS07750
gene id: 145261:N5910_RS07750
uniprot id: A0A9E7RTJ9
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

145261:N5910 RS03375
gene id: 145261:N5910_RS03375
uniprot id: A0A9E7RVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

145261:N5910 RS08680
gene id: 145261:N5910_RS08680
uniprot id: A0A9E7RSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

145261:N5910 RS03045
gene id: 145261:N5910_RS03045
uniprot id: A0A9E7RVU3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

145261:N5910 RS07775
gene id: 145261:N5910_RS07775
uniprot id: A0A9E7ULG1
names: Similarity
messages: Belongs to the UPF0254 family.

145261:N5910 RS02960
gene id: 145261:N5910_RS02960
uniprot id: A0A9E7RVD6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

145261:N5910 RS08900
gene id: 145261:N5910_RS08900
uniprot id: A0A9E7RTM9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

145261:N5910 RS03590
gene id: 145261:N5910_RS03590
uniprot id: A0A9E7RUD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

145261:N5910 RS00745
gene id: 145261:N5910_RS00745
uniprot id: A0A9E7UGX2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

145261:N5910 RS07255
gene id: 145261:N5910_RS07255
uniprot id: A0A9E7RS80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS06035
gene id: 145261:N5910_RS06035
uniprot id: A0A9E7UMC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS05440
gene id: 145261:N5910_RS05440
uniprot id: A0A9E7RSA4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

145261:N5910 RS06395
gene id: 145261:N5910_RS06395
uniprot id: A0A9E7RT09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS03250
gene id: 145261:N5910_RS03250
uniprot id: A0A9E7RU95
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS06135
gene id: 145261:N5910_RS06135
uniprot id: A0A9E7RTM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

145261:N5910 RS08030
gene id: 145261:N5910_RS08030
uniprot id: A0A9E7RSK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

145261:N5910 RS00460
gene id: 145261:N5910_RS00460
uniprot id: A0A9E7RU07
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

145261:N5910 RS01600
gene id: 145261:N5910_RS01600
uniprot id: A0A9E7RY81
names: Similarity
messages: Belongs to the thymidylate kinase family.

145261:N5910 RS05885
gene id: 145261:N5910_RS05885
uniprot id: A0A9E7RTJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

145261:N5910 RS01225
gene id: 145261:N5910_RS01225
uniprot id: A0A9E7UNC3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

145261:N5910 RS01640
gene id: 145261:N5910_RS01640
uniprot id: A0A9E7RV98
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

145261:N5910 RS06080
gene id: 145261:N5910_RS06080
uniprot id: A0A9E7RTA2
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

145261:N5910 RS00790
gene id: 145261:N5910_RS00790
uniprot id: A0A9E7RV45
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

145261:N5910 RS00845
gene id: 145261:N5910_RS00845
uniprot id: A0A9E7UN81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

145261:N5910 RS04235
gene id: 145261:N5910_RS04235
uniprot id: A0A9E7UNR7
names: Similarity
messages: Belongs to the UPF0201 family.

145261:N5910 RS03025
gene id: 145261:N5910_RS03025
uniprot id: A0A9E7RVZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

145261:N5910 RS00865
gene id: 145261:N5910_RS00865
uniprot id: A0A9E7RTD2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

145261:N5910 RS05900
gene id: 145261:N5910_RS05900
uniprot id: A0A9E7RV67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

145261:N5910 RS07940
gene id: 145261:N5910_RS07940
uniprot id: A0A9E7UMW5
names: Similarity
messages: Belongs to the ComB family.

145261:N5910 RS05210
gene id: 145261:N5910_RS05210
uniprot id: A0A9E7RRD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

145261:N5910 RS00965
gene id: 145261:N5910_RS00965
uniprot id: A0A9E7RUK4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

145261:N5910 RS05680
gene id: 145261:N5910_RS05680
uniprot id: A0A9E7UFT5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

145261:N5910 RS08850
gene id: 145261:N5910_RS08850
uniprot id: A0A9E7UN08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

145261:N5910 RS01990
gene id: 145261:N5910_RS01990
uniprot id: A0A9E7UND9
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

145261:N5910 RS06985
gene id: 145261:N5910_RS06985
uniprot id: A0A9E7ULA9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS07685
gene id: 145261:N5910_RS07685
uniprot id: A0A1C7D1E5
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

145261:N5910 RS00735
gene id: 145261:N5910_RS00735
uniprot id: A0A9E7RUX0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

145261:N5910 RS05445
gene id: 145261:N5910_RS05445
uniprot id: A0A9E7RT11
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS02390
gene id: 145261:N5910_RS02390
uniprot id: A0A9E7RVK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS00695
gene id: 145261:N5910_RS00695
uniprot id: A0A9E7RT72
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

145261:N5910 RS02400
gene id: 145261:N5910_RS02400
uniprot id: A0A9E7UHB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

145261:N5910 RS07060
gene id: 145261:N5910_RS07060
uniprot id: A0A9E7ULB4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

145261:N5910 RS05365
gene id: 145261:N5910_RS05365
uniprot id: A0A9E7RSZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

145261:N5910 RS01610
gene id: 145261:N5910_RS01610
uniprot id: A0A9E7RTM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

145261:N5910 RS02555
gene id: 145261:N5910_RS02555
uniprot id: A0A9E7RUT4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

145261:N5910 RS00175
gene id: 145261:N5910_RS00175
uniprot id: A0A9E7RT02
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS00595
gene id: 145261:N5910_RS00595
uniprot id: A0A9E7UN70
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

145261:N5910 RS03585
gene id: 145261:N5910_RS03585
uniprot id: A0A9E7UNF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

145261:N5910 RS09230
gene id: 145261:N5910_RS09230
uniprot id: A0A9E7RU43
names: Similarity
messages: Belongs to the UPF0147 family.

145261:N5910 RS05185
gene id: 145261:N5910_RS05185
uniprot id: A0A9E7RTA4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-94 inactivates the nitrogenase reductase and regulates nitrogenase activity.

145261:N5910 RS00055
gene id: 145261:N5910_RS00055
uniprot id: A0A9E7RUM0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

145261:N5910 RS03260
gene id: 145261:N5910_RS03260
uniprot id: A0A9E7RU72
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS01895
gene id: 145261:N5910_RS01895
uniprot id: A0A9E7UH73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

145261:N5910 RS09175
gene id: 145261:N5910_RS09175
uniprot id: A0A9E7RYD2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

145261:N5910 RS05375
gene id: 145261:N5910_RS05375
uniprot id: A0A9E7UFR1
names: Function
messages: Probably involved in the biogenesis of the ribosome.

145261:N5910 RS06295
gene id: 145261:N5910_RS06295
uniprot id: A0A9E7RTP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

145261:N5910 RS07035
gene id: 145261:N5910_RS07035
uniprot id: A0A9E7RTA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

145261:N5910 RS06990
gene id: 145261:N5910_RS06990
uniprot id: A0A9E7UMV1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

145261:N5910 RS09055
gene id: 145261:N5910_RS09055
uniprot id: A0A9E7RUQ0
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS07660
gene id: 145261:N5910_RS07660
uniprot id: A0A9E7RU39
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

145261:N5910 RS01130
gene id: 145261:N5910_RS01130
uniprot id: A0A9E7RV31
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

145261:N5910 RS06415
gene id: 145261:N5910_RS06415
uniprot id: A0A9E7UFZ3
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

145261:N5910 RS04760
gene id: 145261:N5910_RS04760
uniprot id: A0A9E7RUV0
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS02410
gene id: 145261:N5910_RS02410
uniprot id: A0A9E7UNH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

145261:N5910 RS00265
gene id: 145261:N5910_RS00265
uniprot id: A0A9E7RUY3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS02520
gene id: 145261:N5910_RS02520
uniprot id: A0A9E7RTV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

145261:N5910 RS00295
gene id: 145261:N5910_RS00295
uniprot id: A0A9E7UGT8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

145261:N5910 RS02535
gene id: 145261:N5910_RS02535
uniprot id: A0A9E7RVS5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS01220
gene id: 145261:N5910_RS01220
uniprot id: A0A9E7ULZ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

145261:N5910 RS05960
gene id: 145261:N5910_RS05960
uniprot id: A0A9E7RRE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

145261:N5910 RS04255
gene id: 145261:N5910_RS04255
uniprot id: A0A9E7RUH4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

145261:N5910 RS06040
gene id: 145261:N5910_RS06040
uniprot id: A0A9E7RRR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

145261:N5910 RS09405
gene id: 145261:N5910_RS09405
uniprot id: A0A9E7RU65
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS07100
gene id: 145261:N5910_RS07100
uniprot id: A0A9E7RU03
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

145261:N5910 RS00935
gene id: 145261:N5910_RS00935
uniprot id: A0A9E7RTG0
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

145261:N5910 RS01155
gene id: 145261:N5910_RS01155
uniprot id: A0A9E7UN98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

145261:N5910 RS06615
gene id: 145261:N5910_RS06615
uniprot id: A0A9E7RYC1
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

145261:N5910 RS00900
gene id: 145261:N5910_RS00900
uniprot id: A0A9E7RUL3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS01175
gene id: 145261:N5910_RS01175
uniprot id: A0A9E7RTH3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

145261:N5910 RS03580
gene id: 145261:N5910_RS03580
uniprot id: A0A9E7UNN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

145261:N5910 RS02965
gene id: 145261:N5910_RS02965
uniprot id: A0A9E7RUZ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

145261:N5910 RS04765
gene id: 145261:N5910_RS04765
uniprot id: A0A9E7RT46
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

145261:N5910 RS05950
gene id: 145261:N5910_RS05950
uniprot id: A0A9E7UMB6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

145261:N5910 RS08775
gene id: 145261:N5910_RS08775
uniprot id: A0A9E7UN04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

145261:N5910 RS09200
gene id: 145261:N5910_RS09200
uniprot id: A0A9E7RSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

145261:N5910 RS02050
gene id: 145261:N5910_RS02050
uniprot id: A0A9E7UH88
names: Similarity
messages: Belongs to the UPF0288 family.

145261:N5910 RS04630
gene id: 145261:N5910_RS04630
uniprot id: A0A9E7UMI6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

145261:N5910 RS09400
gene id: 145261:N5910_RS09400
uniprot id: A0A9E7RWG4
names: Similarity
messages: Belongs to the UPF0285 family.

145261:N5910 RS04665
gene id: 145261:N5910_RS04665
uniprot id: A0A9E7RR55
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

145261:N5910 RS02375
gene id: 145261:N5910_RS02375
uniprot id: A0A9E7RXD7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

145261:N5910 RS00920
gene id: 145261:N5910_RS00920
uniprot id: A0A9E7UNA6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

145261:N5910 RS07855
gene id: 145261:N5910_RS07855
uniprot id: A0A9E7ULG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

145261:N5910 RS03530
gene id: 145261:N5910_RS03530
uniprot id: A0A9E7RW61
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

145261:N5910 RS05560
gene id: 145261:N5910_RS05560
uniprot id: A0A9E7RR76
names: Similarity
messages: Belongs to the UPF0145 family.

145261:N5910 RS04860
gene id: 145261:N5910_RS04860
uniprot id: A0A9E7RWB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

145261:N5910 RS02585
gene id: 145261:N5910_RS02585
uniprot id: A0A9E7UNK3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

145261:N5910 RS06915
gene id: 145261:N5910_RS06915
uniprot id: A0A9E7UMU7
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS00490
gene id: 145261:N5910_RS00490
uniprot id: A0A9E7UMI9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS09160
gene id: 145261:N5910_RS09160
uniprot id: A0A9E7UGN5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

145261:N5910 RS01000
gene id: 145261:N5910_RS01000
uniprot id: A0A9E7UN91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

145261:N5910 RS07310
gene id: 145261:N5910_RS07310
uniprot id: A0A9E7RSB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS02515
gene id: 145261:N5910_RS02515
uniprot id: A0A9E7RU04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS06380
gene id: 145261:N5910_RS06380
uniprot id: A0A9E7RTR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

145261:N5910 RS01635
gene id: 145261:N5910_RS01635
uniprot id: A0A9E7RUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

145261:N5910 RS06385
gene id: 145261:N5910_RS06385
uniprot id: A0A9E7RUQ7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

145261:N5910 RS01975
gene id: 145261:N5910_RS01975
uniprot id: A0A9E7UH81
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

145261:N5910 RS08635
gene id: 145261:N5910_RS08635
uniprot id: A0A9E7UNV3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

145261:N5910 RS07840
gene id: 145261:N5910_RS07840
uniprot id: A0A9E7RTZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS07270
gene id: 145261:N5910_RS07270
uniprot id: A0A9E7RTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

145261:N5910 RS06805
gene id: 145261:N5910_RS06805
uniprot id: A0A9E7RSU2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

145261:N5910 RS02910
gene id: 145261:N5910_RS02910
uniprot id: A0A9E7UNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

145261:N5910 RS09250
gene id: 145261:N5910_RS09250
uniprot id: A0A9E7UGP3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

145261:N5910 RS06065
gene id: 145261:N5910_RS06065
uniprot id: A0A9E7RV89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

145261:N5910 RS05855
gene id: 145261:N5910_RS05855
uniprot id: A0A9E7UMP6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS08640
gene id: 145261:N5910_RS08640
uniprot id: A0A9E7RTJ4
names: Similarity
messages: Belongs to the UPF0248 family.

145261:N5910 RS07135
gene id: 145261:N5910_RS07135
uniprot id: A0A9E7ULB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

145261:N5910 RS03090
gene id: 145261:N5910_RS03090
uniprot id: A0A9E7RU26
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

145261:N5910 RS09100
gene id: 145261:N5910_RS09100
uniprot id: A0A9E7UN21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS08950
gene id: 145261:N5910_RS08950
uniprot id: A0A9E7RSX8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

145261:N5910 RS02580
gene id: 145261:N5910_RS02580
uniprot id: A0A9E7UNI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

145261:N5910 RS07000
gene id: 145261:N5910_RS07000
uniprot id: A0A9E7UMH6
names: Similarity
messages: Belongs to the UPF0146 family.

145261:N5910 RS08925
gene id: 145261:N5910_RS08925
uniprot id: A0A9E7RUR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

145261:N5910 RS02465
gene id: 145261:N5910_RS02465
uniprot id: A0A9E7RUS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

145261:N5910 RS02210
gene id: 145261:N5910_RS02210
uniprot id: A0A9E7RXB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

145261:N5910 RS06185
gene id: 145261:N5910_RS06185
uniprot id: A0A9E7UMR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

145261:N5910 RS05905
gene id: 145261:N5910_RS05905
uniprot id: A0A9E7RSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

145261:N5910 RS05975
gene id: 145261:N5910_RS05975
uniprot id: A0A9E7RTK8
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS09000
gene id: 145261:N5910_RS09000
uniprot id: A0A9E7UGM0
names: Similarity
messages: Belongs to the DsrF/TusC family.

145261:N5910 RS06485
gene id: 145261:N5910_RS06485
uniprot id: A0A9E7RTG1
names: Similarity
messages: Belongs to the UPF0292 family.

145261:N5910 RS08480
gene id: 145261:N5910_RS08480
uniprot id: A0A9E7RSS3
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01315
gene id: 145261:N5910_RS01315
uniprot id: A0A9E7UN38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

145261:N5910 RS02485
gene id: 145261:N5910_RS02485
uniprot id: A0A9E7UM75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

145261:N5910 RS03645
gene id: 145261:N5910_RS03645
uniprot id: A0A9E7UNK7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

145261:N5910 RS02545
gene id: 145261:N5910_RS02545
uniprot id: A0A9E7RXF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS02150
gene id: 145261:N5910_RS02150
uniprot id: A0A9E7RTW5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

145261:N5910 RS07715
gene id: 145261:N5910_RS07715
uniprot id: A0A9E7UML9
names: Similarity
messages: Belongs to the MvhD/VhuD family.

145261:N5910 RS03185
gene id: 145261:N5910_RS03185
uniprot id: A0A9E7RU66
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

145261:N5910 RS00310
gene id: 145261:N5910_RS00310
uniprot id: A0A9E7UN58
names: Similarity
messages: Belongs to the CutA family.

145261:N5910 RS05710
gene id: 145261:N5910_RS05710
uniprot id: A0A9E7RRJ6
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS00755
gene id: 145261:N5910_RS00755
uniprot id: A0A9E7UN99
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

145261:N5910 RS07625
gene id: 145261:N5910_RS07625
uniprot id: A0A9E7ULE9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

145261:N5910 RS03560
gene id: 145261:N5910_RS03560
uniprot id: A0A9E7RUF9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

145261:N5910 RS08100
gene id: 145261:N5910_RS08100
uniprot id: A0A9E7UMP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

145261:N5910 RS01305
gene id: 145261:N5910_RS01305
uniprot id: A0A9E7UNC6
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01090
gene id: 145261:N5910_RS01090
uniprot id: A0A9E7RTI3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

145261:N5910 RS07250
gene id: 145261:N5910_RS07250
uniprot id: A0A9E7UMJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS02290
gene id: 145261:N5910_RS02290
uniprot id: A0A9E7UMJ4
names: Similarity
messages: Belongs to the class-I fumarase family.

145261:N5910 RS07085
gene id: 145261:N5910_RS07085
uniprot id: A0A9E7RRY2
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

145261:N5910 RS05415
gene id: 145261:N5910_RS05415
uniprot id: A0A9E7RRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

145261:N5910 RS02365
gene id: 145261:N5910_RS02365
uniprot id: A0A9E7RVG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

145261:N5910 RS00415
gene id: 145261:N5910_RS00415
uniprot id: A0A9E7RT40
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

145261:N5910 RS09060
gene id: 145261:N5910_RS09060
uniprot id: A0A9E7RWB5
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS02530
gene id: 145261:N5910_RS02530
uniprot id: A0A9E7RVJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

145261:N5910 RS00765
gene id: 145261:N5910_RS00765
uniprot id: A0A9E7UN06
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

145261:N5910 RS07265
gene id: 145261:N5910_RS07265
uniprot id: A0A9E7RS91
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

145261:N5910 RS02085
gene id: 145261:N5910_RS02085
uniprot id: A0A9E7RTT5
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

145261:N5910 RS05300
gene id: 145261:N5910_RS05300
uniprot id: A0A9E7UL12
names: Similarity
messages: Belongs to the HisA/HisF family.

145261:N5910 RS06055
gene id: 145261:N5910_RS06055
uniprot id: A0A9E7RTL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

145261:N5910 RS02505
gene id: 145261:N5910_RS02505
uniprot id: A0A9E7UNG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

145261:N5910 RS05430
gene id: 145261:N5910_RS05430
uniprot id: A0A9E7RV08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

145261:N5910 RS03665
gene id: 145261:N5910_RS03665
uniprot id: A0A9E7UNG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

145261:N5910 RS02340
gene id: 145261:N5910_RS02340
uniprot id: A0A9E7UNF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

145261:N5910 RS07425
gene id: 145261:N5910_RS07425
uniprot id: A0A9E7RS37
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

145261:N5910 RS02450
gene id: 145261:N5910_RS02450
uniprot id: A0A9E7RVR4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

145261:N5910 RS07695
gene id: 145261:N5910_RS07695
uniprot id: A0A1C7D1E4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

145261:N5910 RS02575
gene id: 145261:N5910_RS02575
uniprot id: A0A9E7UM81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS08890
gene id: 145261:N5910_RS08890
uniprot id: A0A9E7RW89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

145261:N5910 RS05395
gene id: 145261:N5910_RS05395
uniprot id: A0A9E7UMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

145261:N5910 RS06710
gene id: 145261:N5910_RS06710
uniprot id: A0A9E7RVF9
names: Similarity
messages: Belongs to the DtxR/MntR family.

145261:N5910 RS06175
gene id: 145261:N5910_RS06175
uniprot id: A0A9E7UFX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

145261:N5910 RS01330
gene id: 145261:N5910_RS01330
uniprot id: A0A9E7RTJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

145261:N5910 RS05225
gene id: 145261:N5910_RS05225
uniprot id: A0A9E7UML5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

145261:N5910 RS06375
gene id: 145261:N5910_RS06375
uniprot id: A0A9E7RTP9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

145261:N5910 RS02980
gene id: 145261:N5910_RS02980
uniprot id: A0A9E7UHG3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

145261:N5910 RS01095
gene id: 145261:N5910_RS01095
uniprot id: A0A9E7RTC4
names: Similarity
messages: Belongs to the glutamate synthase family.

145261:N5910 RS03240
gene id: 145261:N5910_RS03240
uniprot id: A0A9E7UNL2
names: Similarity
messages: Belongs to the DEAD box helicase family.

145261:N5910 RS02025
gene id: 145261:N5910_RS02025
uniprot id: A0A9E7RX93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS00850
gene id: 145261:N5910_RS00850
uniprot id: A0A9E7UN10
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

145261:N5910 RS00535
gene id: 145261:N5910_RS00535
uniprot id: A0A9E7RUV8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS02560
gene id: 145261:N5910_RS02560
uniprot id: A0A9E7RVM3
names: Similarity
messages: Belongs to the MEMO1 family.

145261:N5910 RS00930
gene id: 145261:N5910_RS00930
uniprot id: A0A9E7UN14
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

145261:N5910 RS03605
gene id: 145261:N5910_RS03605
uniprot id: A0A9E7RVW5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS04285
gene id: 145261:N5910_RS04285
uniprot id: A0A9E7RW85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

145261:N5910 RS05025
gene id: 145261:N5910_RS05025
uniprot id: A0A9E7RUW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

145261:N5910 RS04415
gene id: 145261:N5910_RS04415
uniprot id: A0A9E7RUP2
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

145261:N5910 RS04840
gene id: 145261:N5910_RS04840
uniprot id: A0A9E7RR79
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

145261:N5910 RS02345
gene id: 145261:N5910_RS02345
uniprot id: A0A9E7UN89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

145261:N5910 RS00145
gene id: 145261:N5910_RS00145
uniprot id: A0A9E7UGS4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

145261:N5910 RS09430
gene id: 145261:N5910_RS09430
uniprot id: A0A9E7ULS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

145261:N5910 RS07180
gene id: 145261:N5910_RS07180
uniprot id: A0A9E7RVL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

145261:N5910 RS01235
gene id: 145261:N5910_RS01235
uniprot id: A0A9E7UN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

145261:N5910 RS00105
gene id: 145261:N5910_RS00105
uniprot id: A0A9E7RUR0
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

145261:N5910 RS03460
gene id: 145261:N5910_RS03460
uniprot id: A0A9E7UNU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

145261:N5910 RS05360
gene id: 145261:N5910_RS05360
uniprot id: A0A9E7RS92
names: Similarity
messages: Belongs to the UPF0440 family.

145261:N5910 RS04055
gene id: 145261:N5910_RS04055
uniprot id: A0A9E7UHQ5
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01190
gene id: 145261:N5910_RS01190
uniprot id: A0A9E7RWX7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

145261:N5910 RS03710
gene id: 145261:N5910_RS03710
uniprot id: A0A9E7RV87
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01065
gene id: 145261:N5910_RS01065
uniprot id: A0A9E7ULY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

145261:N5910 RS00760
gene id: 145261:N5910_RS00760
uniprot id: A0A9E7UN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

145261:N5910 RS03450
gene id: 145261:N5910_RS03450
uniprot id: A0A9E7RXS8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

145261:N5910 RS00895
gene id: 145261:N5910_RS00895
uniprot id: A0A9E7RUZ6
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

145261:N5910 RS08770
gene id: 145261:N5910_RS08770
uniprot id: A0A9E7UN37
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

145261:N5910 RS08825
gene id: 145261:N5910_RS08825
uniprot id: A0A9E7RUD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

145261:N5910 RS06490
gene id: 145261:N5910_RS06490
uniprot id: A0A9E7RRZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

145261:N5910 RS03305
gene id: 145261:N5910_RS03305
uniprot id: A0A9E7UHJ2
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS02405
gene id: 145261:N5910_RS02405
uniprot id: A0A9E7UM71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

145261:N5910 RS06425
gene id: 145261:N5910_RS06425
uniprot id: A0A9E7UMS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

145261:N5910 RS01465
gene id: 145261:N5910_RS01465
uniprot id: A0A9E7UH36
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

145261:N5910 RS02570
gene id: 145261:N5910_RS02570
uniprot id: A0A9E7UHC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

145261:N5910 RS05270
gene id: 145261:N5910_RS05270
uniprot id: A0A9E7RSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

145261:N5910 RS05870
gene id: 145261:N5910_RS05870
uniprot id: A0A9E7RRP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

145261:N5910 RS06045
gene id: 145261:N5910_RS06045
uniprot id: A0A9E7RRE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

145261:N5910 RS00705
gene id: 145261:N5910_RS00705
uniprot id: A0A9E7RUY0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

145261:N5910 RS08855
gene id: 145261:N5910_RS08855
uniprot id: A0A9E7UMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

145261:N5910 RS03550
gene id: 145261:N5910_RS03550
uniprot id: A0A9E7RV71
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

145261:N5910 RS08080
gene id: 145261:N5910_RS08080
uniprot id: A0A9E7UGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

145261:N5910 RS01440
gene id: 145261:N5910_RS01440
uniprot id: A0A9E7RX12
names: Similarity
messages: Belongs to the class-I fumarase family.

145261:N5910 RS05265
gene id: 145261:N5910_RS05265
uniprot id: A0A9E7RUY7
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

145261:N5910 RS04240
gene id: 145261:N5910_RS04240
uniprot id: A0A9E7UNI3
names: Similarity
messages: Belongs to the UPF0200 family.

145261:N5910 RS06075
gene id: 145261:N5910_RS06075
uniprot id: A0A9E7RSJ2
names: Similarity
messages: Belongs to the glutaredoxin family.

145261:N5910 RS03270
gene id: 145261:N5910_RS03270
uniprot id: A0A9E7RW31
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

145261:N5910 RS02255
gene id: 145261:N5910_RS02255
uniprot id: A0A9E7UNF1
names: Similarity
messages: Belongs to the UPF0173 family.

145261:N5910 RS06050
gene id: 145261:N5910_RS06050
uniprot id: A0A9E7RRR3
names: Similarity
messages: Belongs to the aspartokinase family.

145261:N5910 RS06515
gene id: 145261:N5910_RS06515
uniprot id: A0A9E7UMP7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

145261:N5910 RS03135
gene id: 145261:N5910_RS03135
uniprot id: A0A9E7RUA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

145261:N5910 RS07965
gene id: 145261:N5910_RS07965
uniprot id: A0A9E7RU80
names: Similarity
messages: Belongs to the UPF0045 family.

145261:N5910 RS05535
gene id: 145261:N5910_RS05535
uniprot id: A0A9E7UL27
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

145261:N5910 RS04875
gene id: 145261:N5910_RS04875
uniprot id: A0A9E7RSS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

145261:N5910 RS08325
gene id: 145261:N5910_RS08325
uniprot id: A0A9E7UMQ6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS02510
gene id: 145261:N5910_RS02510
uniprot id: A0A9E7UNA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS06445
gene id: 145261:N5910_RS06445
uniprot id: A0A9E7RRN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

145261:N5910 RS00815
gene id: 145261:N5910_RS00815
uniprot id: A0A9E7RTF6
names: Similarity
messages: Belongs to the TPP enzyme family.

145261:N5910 RS00800
gene id: 145261:N5910_RS00800
uniprot id: A0A9E7RUH9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

145261:N5910 RS00420
gene id: 145261:N5910_RS00420
uniprot id: A0A9E7RT87
names: Similarity
messages: Belongs to the UPF0107 family.

145261:N5910 RS08725
gene id: 145261:N5910_RS08725
uniprot id: A0A9E7RW68
names: Similarity
messages: Belongs to the FrhG family.

145261:N5910 RS08735
gene id: 145261:N5910_RS08735
uniprot id: A0A9E7RTK4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

145261:N5910 RS06810
gene id: 145261:N5910_RS06810
uniprot id: A0A9E7RTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

145261:N5910 RS05540
gene id: 145261:N5910_RS05540
uniprot id: A0A9E7UMN0
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

145261:N5910 RS08515
gene id: 145261:N5910_RS08515
uniprot id: A0A9E7RTV5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS01415
gene id: 145261:N5910_RS01415
uniprot id: A0A9E7RTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

145261:N5910 RS00600
gene id: 145261:N5910_RS00600
uniprot id: A0A9E7UMZ6
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

145261:N5910 RS00485
gene id: 145261:N5910_RS00485
uniprot id: A0A9E7ULV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

145261:N5910 RS00505
gene id: 145261:N5910_RS00505
uniprot id: A0A9E7UMZ0
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

145261:N5910 RS04820
gene id: 145261:N5910_RS04820
uniprot id: A0A9E7UM60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

145261:N5910 RS02480
gene id: 145261:N5910_RS02480
uniprot id: A0A9E7UHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

145261:N5910 RS08555
gene id: 145261:N5910_RS08555
uniprot id: A0A9E7UMZ7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

145261:N5910 RS01210
gene id: 145261:N5910_RS01210
uniprot id: A0A9E7RTK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

145261:N5910 RS09415
gene id: 145261:N5910_RS09415
uniprot id: A0A9E7RUK7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

145261:N5910 RS00720
gene id: 145261:N5910_RS00720
uniprot id: A0A9E7RWQ7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

145261:N5910 RS07115
gene id: 145261:N5910_RS07115
uniprot id: A0A9E7RSY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

145261:N5910 RS07210
gene id: 145261:N5910_RS07210
uniprot id: A0A9E7ULC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

145261:N5910 RS04100
gene id: 145261:N5910_RS04100
uniprot id: A0A9E7RWD6
names: Similarity
messages: Belongs to the FTR family.

145261:N5910 RS02420
gene id: 145261:N5910_RS02420
uniprot id: A0A9E7UNG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS07620
gene id: 145261:N5910_RS07620
uniprot id: A0A9E7UG97
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

145261:N5910 RS00515
gene id: 145261:N5910_RS00515
uniprot id: A0A9E7RT51
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

145261:N5910 RS09170
gene id: 145261:N5910_RS09170
uniprot id: A0A9E7ULQ2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

145261:N5910 RS03030
gene id: 145261:N5910_RS03030
uniprot id: A0A9E7RXM9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

145261:N5910 RS01150
gene id: 145261:N5910_RS01150
uniprot id: A0A9E7UNB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

145261:N5910 RS07825
gene id: 145261:N5910_RS07825
uniprot id: A0A9E7RVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS04245
gene id: 145261:N5910_RS04245
uniprot id: A0A9E7RUL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

145261:N5910 RS07365
gene id: 145261:N5910_RS07365
uniprot id: A0A9E7RVN5
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS05775
gene id: 145261:N5910_RS05775
uniprot id: A0A9E7UML3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

145261:N5910 RS01620
gene id: 145261:N5910_RS01620
uniprot id: A0A9E7RVF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

145261:N5910 RS02430
gene id: 145261:N5910_RS02430
uniprot id: A0A9E7RTZ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

145261:N5910 RS07725
gene id: 145261:N5910_RS07725
uniprot id: A0A9E7RS85
names: Similarity
messages: Belongs to the MvhD/VhuD family.

145261:N5910 RS01170
gene id: 145261:N5910_RS01170
uniprot id: A0A9E7RTD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

145261:N5910 RS01525
gene id: 145261:N5910_RS01525
uniprot id: A0A9E7RUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

145261:N5910 RS09075
gene id: 145261:N5910_RS09075
uniprot id: A0A9E7RUG4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

145261:N5910 RS03050
gene id: 145261:N5910_RS03050
uniprot id: A0A9E7RWL9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

145261:N5910 RS04405
gene id: 145261:N5910_RS04405
uniprot id: A0A9E7UNS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

145261:N5910 RS01165
gene id: 145261:N5910_RS01165
uniprot id: A0A9E7RTJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

145261:N5910 RS02355
gene id: 145261:N5910_RS02355
uniprot id: A0A9E7RTS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

145261:N5910 RS08590
gene id: 145261:N5910_RS08590
uniprot id: A0A9E7RUF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

145261:N5910 RS03445
gene id: 145261:N5910_RS03445
uniprot id: A0A9E7UMJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

145261:N5910 RS04790
gene id: 145261:N5910_RS04790
uniprot id: A0A9E7RR80
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

145261:N5910 RS02315
gene id: 145261:N5910_RS02315
uniprot id: A0A9E7UNT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

145261:N5910 RS01295
gene id: 145261:N5910_RS01295
uniprot id: A0A9E7UH21
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS01355
gene id: 145261:N5910_RS01355
uniprot id: A0A9E7RUQ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

145261:N5910 RS04810
gene id: 145261:N5910_RS04810
uniprot id: A0A9E7UMJ3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

145261:N5910 RS00375
gene id: 145261:N5910_RS00375
uniprot id: A0A9E7RTB0
names: Similarity
messages: Belongs to the SfsA family.

145261:N5910 RS03610
gene id: 145261:N5910_RS03610
uniprot id: A0A9E7RW73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

145261:N5910 RS00780
gene id: 145261:N5910_RS00780
uniprot id: A0A9E7RTC3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS06000
gene id: 145261:N5910_RS06000
uniprot id: A0A9E7RSI2
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

145261:N5910 RS06405
gene id: 145261:N5910_RS06405
uniprot id: A0A9E7RTE9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

145261:N5910 RS08495
gene id: 145261:N5910_RS08495
uniprot id: A0A9E7RSS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

145261:N5910 RS01260
gene id: 145261:N5910_RS01260
uniprot id: A0A9E7RVB2
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

145261:N5910 RS06760
gene id: 145261:N5910_RS06760
uniprot id: A0A9E7UMQ9
names: Similarity
messages: Belongs to the UPF0216 family.

145261:N5910 RS05380
gene id: 145261:N5910_RS05380
uniprot id: A0A9E7UL16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

145261:N5910 RS06875
gene id: 145261:N5910_RS06875
uniprot id: A0A9E7RVH5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

145261:N5910 RS03325
gene id: 145261:N5910_RS03325
uniprot id: A0A9E7UNE4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

145261:N5910 RS05530
gene id: 145261:N5910_RS05530
uniprot id: A0A9E7UFS3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

145261:N5910 RS00855
gene id: 145261:N5910_RS00855
uniprot id: A0A9E7RTF0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

145261:N5910 RS07040
gene id: 145261:N5910_RS07040
uniprot id: A0A9E7RSX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

145261:N5910 RS08650
gene id: 145261:N5910_RS08650
uniprot id: A0A9E7RSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

145261:N5910 RS04835
gene id: 145261:N5910_RS04835
uniprot id: A0A9E7RQV2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

145261:N5910 RS02380
gene id: 145261:N5910_RS02380
uniprot id: A0A9E7RV39
names: Similarity
messages: Belongs to the SUI1 family.

145261:N5910 RS04990
gene id: 145261:N5910_RS04990
uniprot id: A0A9E7UMH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

145261:N5910 RS02455
gene id: 145261:N5910_RS02455
uniprot id: A0A9E7RXE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

145261:N5910 RS02440
gene id: 145261:N5910_RS02440
uniprot id: A0A9E7RTX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

145261:N5910 RS07290
gene id: 145261:N5910_RS07290
uniprot id: A0A9E7RT07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

145261:N5910 RS05815
gene id: 145261:N5910_RS05815
uniprot id: A0A9E7RTI8
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

145261:N5910 RS02955
gene id: 145261:N5910_RS02955
uniprot id: A0A9E7RXL8
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

145261:N5910 RS08795
gene id: 145261:N5910_RS08795
uniprot id: A0A9E7RSV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

145261:N5910 RS00390
gene id: 145261:N5910_RS00390
uniprot id: A0A9E7UN86
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

145261:N5910 RS01870
gene id: 145261:N5910_RS01870
uniprot id: A0A9E7RUX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

145261:N5910 RS07090
gene id: 145261:N5910_RS07090
uniprot id: A0A9E7RS65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

145261:N5910 RS00510
gene id: 145261:N5910_RS00510
uniprot id: A0A9E7RTA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

145261:N5910 RS06845
gene id: 145261:N5910_RS06845
uniprot id: A0A9E7RS25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

145261:N5910 RS07535
gene id: 145261:N5910_RS07535
uniprot id: A0A9E7RTV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

145261:N5910 RS00805
gene id: 145261:N5910_RS00805
uniprot id: A0A9E7RU50
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

145261:N5910 RS00095
gene id: 145261:N5910_RS00095
uniprot id: A0A9E7RSZ0
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS05215
gene id: 145261:N5910_RS05215
uniprot id: A0A9E7UFP8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

145261:N5910 RS03365
gene id: 145261:N5910_RS03365
uniprot id: A0A9E7RV44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS08385
gene id: 145261:N5910_RS08385
uniprot id: A0A9E7ULK3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

145261:N5910 RS07830
gene id: 145261:N5910_RS07830
uniprot id: A0A9E7RTK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS02900
gene id: 145261:N5910_RS02900
uniprot id: A0A9E7UHF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

145261:N5910 RS06140
gene id: 145261:N5910_RS06140
uniprot id: A0A9E7RV99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

145261:N5910 RS00875
gene id: 145261:N5910_RS00875
uniprot id: A0A9E7RV55
names: Similarity
messages: Belongs to the PDCD5 family.

145261:N5910 RS01960
gene id: 145261:N5910_RS01960
uniprot id: A0A9E7UHV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

145261:N5910 RS03480
gene id: 145261:N5910_RS03480
uniprot id: A0A9E7UHK5
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

145261:N5910 RS03565
gene id: 145261:N5910_RS03565
uniprot id: A0A9E7UHL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

145261:N5910 RS07545
gene id: 145261:N5910_RS07545
uniprot id: A0A9E7UG91
names: Similarity
messages: Belongs to the thymidylate kinase family.

145261:N5910 RS06780
gene id: 145261:N5910_RS06780
uniprot id: A0A9E7RS18
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

145261:N5910 RS02095
gene id: 145261:N5910_RS02095
uniprot id: A0A9E7RVL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

145261:N5910 RS09145
gene id: 145261:N5910_RS09145
uniprot id: A0A9E7RTR7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

145261:N5910 RS08780
gene id: 145261:N5910_RS08780
uniprot id: A0A9E7UMT0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

145261:N5910 RS02470
gene id: 145261:N5910_RS02470
uniprot id: A0A9E7RVL3
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS06275
gene id: 145261:N5910_RS06275
uniprot id: A0A9E7RRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

145261:N5910 RS03545
gene id: 145261:N5910_RS03545
uniprot id: A0A9E7RVK1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

145261:N5910 RS03570
gene id: 145261:N5910_RS03570
uniprot id: A0A9E7UMD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

145261:N5910 RS03075
gene id: 145261:N5910_RS03075
uniprot id: A0A9E7UNK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

145261:N5910 RS00610
gene id: 145261:N5910_RS00610
uniprot id: A0A9E7RT62
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

145261:N5910 RS03905
gene id: 145261:N5910_RS03905
uniprot id: A0A9E7UNP8
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

145261:N5910 RS09425
gene id: 145261:N5910_RS09425
uniprot id: A0A9E7UGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

145261:N5910 RS04340
gene id: 145261:N5910_RS04340
uniprot id: A0A9E7RW44
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS06115
gene id: 145261:N5910_RS06115
uniprot id: A0A9E7RRS4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

145261:N5910 RS02475
gene id: 145261:N5910_RS02475
uniprot id: A0A9E7RU10
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

145261:N5910 RS08095
gene id: 145261:N5910_RS08095
uniprot id: A0A9E7UMX3
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

145261:N5910 RS01940
gene id: 145261:N5910_RS01940
uniprot id: A0A9E7RVJ7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

145261:N5910 RS08460
gene id: 145261:N5910_RS08460
uniprot id: A0A9E7ULK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

145261:N5910 RS02525
gene id: 145261:N5910_RS02525
uniprot id: A0A9E7RTY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

145261:N5910 RS01160
gene id: 145261:N5910_RS01160
uniprot id: A0A9E7UN30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

145261:N5910 RS07295
gene id: 145261:N5910_RS07295
uniprot id: A0A9E7RTS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS07055
gene id: 145261:N5910_RS07055
uniprot id: A0A9E7UG44
names: Similarity
messages: Belongs to the AAA ATPase family.

145261:N5910 RS00315
gene id: 145261:N5910_RS00315
uniprot id: A0A9E7UMY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

145261:N5910 RS09305
gene id: 145261:N5910_RS09305
uniprot id: A0A9E7RWE9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

145261:N5910 RS07130
gene id: 145261:N5910_RS07130
uniprot id: A0A9E7UG52
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

145261:N5910 RS07045
gene id: 145261:N5910_RS07045
uniprot id: A0A9E7RTN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

145261:N5910 RS02590
gene id: 145261:N5910_RS02590
uniprot id: A0A9E7RUS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

145261:N5910 RS00075
gene id: 145261:N5910_RS00075
uniprot id: A0A9E7UN71
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

145261:N5910 RS07835
gene id: 145261:N5910_RS07835
uniprot id: A0A9E7RT86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS06125
gene id: 145261:N5910_RS06125
uniprot id: A0A9E7RRS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

145261:N5910 RS09410
gene id: 145261:N5910_RS09410
uniprot id: A0A9E7RTU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

145261:N5910 RS03485
gene id: 145261:N5910_RS03485
uniprot id: A0A9E7UMD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

145261:N5910 RS00135
gene id: 145261:N5910_RS00135
uniprot id: A0A9E7RUN0
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

145261:N5910 RS00495
gene id: 145261:N5910_RS00495
uniprot id: A0A9E7UN88
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

145261:N5910 RS06085
gene id: 145261:N5910_RS06085
uniprot id: A0A9E7RRT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

145261:N5910 RS06940
gene id: 145261:N5910_RS06940
uniprot id: A0A9E7RS42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

145261:N5910 RS00260
gene id: 145261:N5910_RS00260
uniprot id: A0A9E7RUS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

145261:N5910 RS08805
gene id: 145261:N5910_RS08805
uniprot id: A0A9E7RUM2
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

145261:N5910 RS02435
gene id: 145261:N5910_RS02435
uniprot id: A0A9E7RTU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

145261:N5910 RS01945
gene id: 145261:N5910_RS01945
uniprot id: A0A9E7RX82
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

145261:N5910 RS02985
gene id: 145261:N5910_RS02985
uniprot id: A0A9E7UMA8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS09180
gene id: 145261:N5910_RS09180
uniprot id: A0A9E7UN56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

145261:N5910 RS01735
gene id: 145261:N5910_RS01735
uniprot id: A0A9E7UM32
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

145261:N5910 RS02360
gene id: 145261:N5910_RS02360
uniprot id: A0A9E7RTW2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

145261:N5910 RS09110
gene id: 145261:N5910_RS09110
uniprot id: A0A9E7RT00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

145261:N5910 RS01570
gene id: 145261:N5910_RS01570
uniprot id: A0A9E7UM20
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

145261:N5910 RS00785
gene id: 145261:N5910_RS00785
uniprot id: A0A9E7RUZ0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

145261:N5910 RS06430
gene id: 145261:N5910_RS06430
uniprot id: A0A9E7UMP4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

145261:N5910 RS04770
gene id: 145261:N5910_RS04770
uniprot id: A0A9E7RUT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

145261:N5910 RS02425
gene id: 145261:N5910_RS02425
uniprot id: A0A9E7UN95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

145261:N5910 RS07095
gene id: 145261:N5910_RS07095
uniprot id: A0A9E7RTY1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

145261:N5910 RS07875
gene id: 145261:N5910_RS07875
uniprot id: A0A1C7D1E2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

145261:N5910 RS00080
gene id: 145261:N5910_RS00080
uniprot id: A0A9E7UN45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

145261:N5910 RS01965
gene id: 145261:N5910_RS01965
uniprot id: A0A9E7RVE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

145261:N5910 RS01335
gene id: 145261:N5910_RS01335
uniprot id: A0A9E7RV56
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

145261:N5910 RS07020
gene id: 145261:N5910_RS07020
uniprot id: A0A9E7RTX0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

145261:N5910 RS07815
gene id: 145261:N5910_RS07815
uniprot id: A0A9E7RU60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

145261:N5910 RS04420
gene id: 145261:N5910_RS04420
uniprot id: A0A9E7RUI7
names: Subcellular Location Annotation
messages: Membrane

145261:N5910 RS00455
gene id: 145261:N5910_RS00455
uniprot id: A0A9E7RUD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

145261:N5910 RS02385
gene id: 145261:N5910_RS02385
uniprot id: A0A9E7RUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

145261:N5910 RS01760
gene id: 145261:N5910_RS01760
uniprot id: A0A9E7RTL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

145261:N5910 RS00950
gene id: 145261:N5910_RS00950
uniprot id: A0A9E7RV10
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.