1437875:CFRA RS03300
gene id: 1437875:CFRA_RS03300
uniprot id: A0A1L7CRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1437875:CFRA RS01070
gene id: 1437875:CFRA_RS01070
uniprot id: A0A1L7CQL7
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1437875:CFRA RS09505
gene id: 1437875:CFRA_RS09505
uniprot id: A0A1L7CUD7
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1437875:CFRA RS02115
gene id: 1437875:CFRA_RS02115
uniprot id: A0A1L7CR04
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS01795
gene id: 1437875:CFRA_RS01795
uniprot id: A0A1L7CQW4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1437875:CFRA RS02970
gene id: 1437875:CFRA_RS02970
uniprot id: A0A1L7CRF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1437875:CFRA RS11260
gene id: 1437875:CFRA_RS11260
uniprot id: A0A1L7CV68
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1437875:CFRA RS11230
gene id: 1437875:CFRA_RS11230
uniprot id: A0A1L7CV93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1437875:CFRA RS04235
gene id: 1437875:CFRA_RS04235
uniprot id: A0A1L7CRX9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02660
gene id: 1437875:CFRA_RS02660
uniprot id: A0A1L7CR85
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS08800
gene id: 1437875:CFRA_RS08800
uniprot id: A0A1L7CU26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1437875:CFRA RS08955
gene id: 1437875:CFRA_RS08955
uniprot id: A0A1L7CU75
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1437875:CFRA RS03710
gene id: 1437875:CFRA_RS03710
uniprot id: A0A1L7CRV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1437875:CFRA RS07880
gene id: 1437875:CFRA_RS07880
uniprot id: A0A1L7CTR0
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06260
gene id: 1437875:CFRA_RS06260
uniprot id: A0A1L7CST6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

1437875:CFRA RS07180
gene id: 1437875:CFRA_RS07180
uniprot id: A0A1L7CTB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1437875:CFRA RS08095
gene id: 1437875:CFRA_RS08095
uniprot id: A0A1L7CTT9
names: Similarity
messages: Belongs to the peptidase C40 family.

1437875:CFRA RS03945
gene id: 1437875:CFRA_RS03945
uniprot id: A0A1L7CRW5
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1437875:CFRA RS07605
gene id: 1437875:CFRA_RS07605
uniprot id: A0A1L7CTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1437875:CFRA RS09565
gene id: 1437875:CFRA_RS09565
uniprot id: A0A1L7CUJ7
names: Similarity
messages: Belongs to the fructosamine kinase family.

1437875:CFRA RS05740
gene id: 1437875:CFRA_RS05740
uniprot id: A0A1L7CSM0
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

1437875:CFRA RS07035
gene id: 1437875:CFRA_RS07035
uniprot id: A0A1L7CTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1437875:CFRA RS05590
gene id: 1437875:CFRA_RS05590
uniprot id: A0A1L7CSM9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02040
gene id: 1437875:CFRA_RS02040
uniprot id: A0A1L7CQZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1437875:CFRA RS09635
gene id: 1437875:CFRA_RS09635
uniprot id: A0A1L7CUE9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05255
gene id: 1437875:CFRA_RS05255
uniprot id: A0A1L7CSH2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS06405
gene id: 1437875:CFRA_RS06405
uniprot id: A0A1L7CSX5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

1437875:CFRA RS01970
gene id: 1437875:CFRA_RS01970
uniprot id: A0A1L7CQY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1437875:CFRA RS01520
gene id: 1437875:CFRA_RS01520
uniprot id: A0A1L7CQS3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1437875:CFRA RS00645
gene id: 1437875:CFRA_RS00645
uniprot id: A0A1L7CQC4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1437875:CFRA RS02885
gene id: 1437875:CFRA_RS02885
uniprot id: A0A1L7CRE3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1437875:CFRA RS02790
gene id: 1437875:CFRA_RS02790
uniprot id: A0A1L7CRB5
names: Similarity
messages: Belongs to the AccD/PCCB family.

1437875:CFRA RS09320
gene id: 1437875:CFRA_RS09320
uniprot id: A0A1L7CUB0
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1437875:CFRA RS10575
gene id: 1437875:CFRA_RS10575
uniprot id: A0A1L7CV02
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

1437875:CFRA RS09065
gene id: 1437875:CFRA_RS09065
uniprot id: A0A1L7CU86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1437875:CFRA RS05200
gene id: 1437875:CFRA_RS05200
uniprot id: A0A1L7CSD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1437875:CFRA RS01765
gene id: 1437875:CFRA_RS01765
uniprot id: A0A1L7CQX6
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1437875:CFRA RS06155
gene id: 1437875:CFRA_RS06155
uniprot id: A0A1L7CT24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1437875:CFRA RS03545
gene id: 1437875:CFRA_RS03545
uniprot id: A0A1L7CRQ2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1437875:CFRA RS05725
gene id: 1437875:CFRA_RS05725
uniprot id: A0A1L7CSM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1437875:CFRA RS01195
gene id: 1437875:CFRA_RS01195
uniprot id: A0A1L7CQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Membrane

1437875:CFRA RS00225
gene id: 1437875:CFRA_RS00225
uniprot id: A0A1L7CQ75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1437875:CFRA RS11015
gene id: 1437875:CFRA_RS11015
uniprot id: A0A1L7CV32
names: Similarity
messages: Belongs to the universal stress protein A family.

1437875:CFRA RS10345
gene id: 1437875:CFRA_RS10345
uniprot id: A0A1L7CUP3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

1437875:CFRA RS06120
gene id: 1437875:CFRA_RS06120
uniprot id: A0A1L7CST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1437875:CFRA RS07785
gene id: 1437875:CFRA_RS07785
uniprot id: A0A1L7CTK3
names: Similarity
messages: Belongs to the HypD family.

1437875:CFRA RS02475
gene id: 1437875:CFRA_RS02475
uniprot id: A0A1L7CR52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1437875:CFRA RS10385
gene id: 1437875:CFRA_RS10385
uniprot id: A0A1L7CUV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1437875:CFRA RS04035
gene id: 1437875:CFRA_RS04035
uniprot id: A0A1L7CRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1437875:CFRA RS06385
gene id: 1437875:CFRA_RS06385
uniprot id: A0A1L7CT07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1437875:CFRA RS06150
gene id: 1437875:CFRA_RS06150
uniprot id: A0A1L7CSV6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1437875:CFRA RS05865
gene id: 1437875:CFRA_RS05865
uniprot id: A0A1L7CSM7
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1437875:CFRA RS05210
gene id: 1437875:CFRA_RS05210
uniprot id: A0A1L7CSB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1437875:CFRA RS03385
gene id: 1437875:CFRA_RS03385
uniprot id: A0A1L7CRK1
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1437875:CFRA RS05735
gene id: 1437875:CFRA_RS05735
uniprot id: A0A1L7CSK4
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

1437875:CFRA RS01800
gene id: 1437875:CFRA_RS01800
uniprot id: A0A1L7CQV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1437875:CFRA RS06360
gene id: 1437875:CFRA_RS06360
uniprot id: A0A1L7CSX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1437875:CFRA RS10370
gene id: 1437875:CFRA_RS10370
uniprot id: A0A1L7CUT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1437875:CFRA RS00600
gene id: 1437875:CFRA_RS00600
uniprot id: A0A1L7CQC8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1437875:CFRA RS08130
gene id: 1437875:CFRA_RS08130
uniprot id: A0A1L7CTR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

1437875:CFRA RS07255
gene id: 1437875:CFRA_RS07255
uniprot id: A0A1L7CTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1437875:CFRA RS07160
gene id: 1437875:CFRA_RS07160
uniprot id: A0A1L7CTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1437875:CFRA RS04895
gene id: 1437875:CFRA_RS04895
uniprot id: A0A1L7CSB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1437875:CFRA RS09155
gene id: 1437875:CFRA_RS09155
uniprot id: A0A1L7CU76
names: Similarity
messages: Belongs to the CmpA/NrtA family.

1437875:CFRA RS06840
gene id: 1437875:CFRA_RS06840
uniprot id: A0A1L7CT47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1437875:CFRA RS03345
gene id: 1437875:CFRA_RS03345
uniprot id: A0A1L7CRN5
names: Similarity
messages: Belongs to the citrate synthase family.

1437875:CFRA RS08405
gene id: 1437875:CFRA_RS08405
uniprot id: A0A1L7CTV5
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1437875:CFRA RS08375
gene id: 1437875:CFRA_RS08375
uniprot id: A0A1L7CTX9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1437875:CFRA RS08735
gene id: 1437875:CFRA_RS08735
uniprot id: A0A1L7CU09
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS00580
gene id: 1437875:CFRA_RS00580
uniprot id: A0A1L7CQE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS04140
gene id: 1437875:CFRA_RS04140
uniprot id: A0A1L7CS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

1437875:CFRA RS04755
gene id: 1437875:CFRA_RS04755
uniprot id: A0A1L7CS62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1437875:CFRA RS05370
gene id: 1437875:CFRA_RS05370
uniprot id: A0A1L7CSG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS03805
gene id: 1437875:CFRA_RS03805
uniprot id: A0A1L7CRU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1437875:CFRA RS05575
gene id: 1437875:CFRA_RS05575
uniprot id: A0A1L7CSQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS09555
gene id: 1437875:CFRA_RS09555
uniprot id: A0A1L7CUE5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1437875:CFRA RS03525
gene id: 1437875:CFRA_RS03525
uniprot id: A0A1L7CRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1437875:CFRA RS10595
gene id: 1437875:CFRA_RS10595
uniprot id: A0A1L7CUT9
names: Similarity
messages: Belongs to the heme oxygenase family.

1437875:CFRA RS09970
gene id: 1437875:CFRA_RS09970
uniprot id: A0A1L7CUM2
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1437875:CFRA RS09670
gene id: 1437875:CFRA_RS09670
uniprot id: A0A1L7CUM7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1437875:CFRA RS08860
gene id: 1437875:CFRA_RS08860
uniprot id: A0A1L7CU31
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1437875:CFRA RS10700
gene id: 1437875:CFRA_RS10700
uniprot id: A0A1L7CUU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS10560
gene id: 1437875:CFRA_RS10560
uniprot id: A0A1L7CUZ3
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1437875:CFRA RS10815
gene id: 1437875:CFRA_RS10815
uniprot id: A0A1L7CV49
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02005
gene id: 1437875:CFRA_RS02005
uniprot id: A0A1L7CQY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1437875:CFRA RS11160
gene id: 1437875:CFRA_RS11160
uniprot id: A0A1L7CV86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1437875:CFRA RS05680
gene id: 1437875:CFRA_RS05680
uniprot id: A0A1L7CSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS04740
gene id: 1437875:CFRA_RS04740
uniprot id: A0A1L7CS78
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1437875:CFRA RS00635
gene id: 1437875:CFRA_RS00635
uniprot id: A0A1L7CQD1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1437875:CFRA RS01835
gene id: 1437875:CFRA_RS01835
uniprot id: A0A1L7CQX2
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06640
gene id: 1437875:CFRA_RS06640
uniprot id: A0A1L7CSZ8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1437875:CFRA RS10565
gene id: 1437875:CFRA_RS10565
uniprot id: A0A1L7CUS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

1437875:CFRA RS02605
gene id: 1437875:CFRA_RS02605
uniprot id: A0A1L7CR81
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1437875:CFRA RS01365
gene id: 1437875:CFRA_RS01365
uniprot id: A0A1L7CQQ7
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1437875:CFRA RS01255
gene id: 1437875:CFRA_RS01255
uniprot id: A0A1L7CQM9
names: Subcellular Location Annotation
messages: Cytoplasm

1437875:CFRA RS03490
gene id: 1437875:CFRA_RS03490
uniprot id: A0A1L7CRP1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1437875:CFRA RS00825
gene id: 1437875:CFRA_RS00825
uniprot id: A0A1L7CQG1
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1437875:CFRA RS06750
gene id: 1437875:CFRA_RS06750
uniprot id: A0A1L7CT19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1437875:CFRA RS01975
gene id: 1437875:CFRA_RS01975
uniprot id: A0A1L7CQZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1437875:CFRA RS09640
gene id: 1437875:CFRA_RS09640
uniprot id: A0A1L7CUK0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1437875:CFRA RS02770
gene id: 1437875:CFRA_RS02770
uniprot id: A0A1L7CRC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1437875:CFRA RS08615
gene id: 1437875:CFRA_RS08615
uniprot id: A0A1L7CU24
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1437875:CFRA RS05285
gene id: 1437875:CFRA_RS05285
uniprot id: A0A1L7CSF0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00005
gene id: 1437875:CFRA_RS00005
uniprot id: A0A1L7CQ47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1437875:CFRA RS00935
gene id: 1437875:CFRA_RS00935
uniprot id: A0A1L7CQJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1437875:CFRA RS00865
gene id: 1437875:CFRA_RS00865
uniprot id: A0A1L7CQJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1437875:CFRA RS05045
gene id: 1437875:CFRA_RS05045
uniprot id: A0A1L7CSB1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1437875:CFRA RS06785
gene id: 1437875:CFRA_RS06785
uniprot id: A0A1L7CT37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1437875:CFRA RS00010
gene id: 1437875:CFRA_RS00010
uniprot id: A0A1L7CQ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1437875:CFRA RS03360
gene id: 1437875:CFRA_RS03360
uniprot id: A0A1L7CRM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1437875:CFRA RS07320
gene id: 1437875:CFRA_RS07320
uniprot id: A0A1L7CTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1437875:CFRA RS02340
gene id: 1437875:CFRA_RS02340
uniprot id: A0A1L7CR56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

1437875:CFRA RS06305
gene id: 1437875:CFRA_RS06305
uniprot id: A0A1L7CSW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS04745
gene id: 1437875:CFRA_RS04745
uniprot id: A0A1L7CS75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1437875:CFRA RS11295
gene id: 1437875:CFRA_RS11295
uniprot id: A0A1L7CV33
names: Similarity
messages: Belongs to the thioredoxin family.

1437875:CFRA RS05235
gene id: 1437875:CFRA_RS05235
uniprot id: A0A1L7CSK5
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1437875:CFRA RS02365
gene id: 1437875:CFRA_RS02365
uniprot id: A0A1L7CR54
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1437875:CFRA RS01085
gene id: 1437875:CFRA_RS01085
uniprot id: A0A1L7CQL9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1437875:CFRA RS02560
gene id: 1437875:CFRA_RS02560
uniprot id: A0A1L7CR80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS05840
gene id: 1437875:CFRA_RS05840
uniprot id: A0A1L7CSN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS04260
gene id: 1437875:CFRA_RS04260
uniprot id: A0A1L7CS14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS07250
gene id: 1437875:CFRA_RS07250
uniprot id: A0A1L7CTC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1437875:CFRA RS05310
gene id: 1437875:CFRA_RS05310
uniprot id: A0A1L7CSI1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1437875:CFRA RS00980
gene id: 1437875:CFRA_RS00980
uniprot id: A0A1L7CQI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1437875:CFRA RS10545
gene id: 1437875:CFRA_RS10545
uniprot id: A0A1L7CUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS06470
gene id: 1437875:CFRA_RS06470
uniprot id: A0A1L7CSZ9
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

1437875:CFRA RS08810
gene id: 1437875:CFRA_RS08810
uniprot id: A0A1L7CU21
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1437875:CFRA RS08710
gene id: 1437875:CFRA_RS08710
uniprot id: A0A1L7CU29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1437875:CFRA RS08050
gene id: 1437875:CFRA_RS08050
uniprot id: A0A1L7CTQ0
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

1437875:CFRA RS02255
gene id: 1437875:CFRA_RS02255
uniprot id: A0A1L7CR58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1437875:CFRA RS03485
gene id: 1437875:CFRA_RS03485
uniprot id: A0A1L7CRR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1437875:CFRA RS00300
gene id: 1437875:CFRA_RS00300
uniprot id: A0A1L7CQ84
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02245
gene id: 1437875:CFRA_RS02245
uniprot id: A0A1L7CR36
names: Similarity
messages: Belongs to the WXG100 family.

1437875:CFRA RS02915
gene id: 1437875:CFRA_RS02915
uniprot id: A0A1L7CRF2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1437875:CFRA RS06345
gene id: 1437875:CFRA_RS06345
uniprot id: A0A1L7CT15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1437875:CFRA RS06045
gene id: 1437875:CFRA_RS06045
uniprot id: A0A1L7CSS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1437875:CFRA RS04390
gene id: 1437875:CFRA_RS04390
uniprot id: A0A1L7CS36
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1437875:CFRA RS07560
gene id: 1437875:CFRA_RS07560
uniprot id: A0A1L7CTK7
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

1437875:CFRA RS08180
gene id: 1437875:CFRA_RS08180
uniprot id: A0A1L7CTR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1437875:CFRA RS01785
gene id: 1437875:CFRA_RS01785
uniprot id: A0A1L7CQV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1437875:CFRA RS09895
gene id: 1437875:CFRA_RS09895
uniprot id: A0A1L7CUL2
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1437875:CFRA RS00840
gene id: 1437875:CFRA_RS00840
uniprot id: A0A1L7CQF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1437875:CFRA RS06770
gene id: 1437875:CFRA_RS06770
uniprot id: A0A1L7CT66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1437875:CFRA RS02135
gene id: 1437875:CFRA_RS02135
uniprot id: A0A1L7CR22
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS07645
gene id: 1437875:CFRA_RS07645
uniprot id: A0A1L7CTI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1437875:CFRA RS09230
gene id: 1437875:CFRA_RS09230
uniprot id: A0A1L7CUA4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1437875:CFRA RS08700
gene id: 1437875:CFRA_RS08700
uniprot id: A0A1L7CTZ5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS08155
gene id: 1437875:CFRA_RS08155
uniprot id: A0A1L7CTU2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1437875:CFRA RS06745
gene id: 1437875:CFRA_RS06745
uniprot id: A0A1L7CT35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

1437875:CFRA RS01980
gene id: 1437875:CFRA_RS01980
uniprot id: A0A1L7CR08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS02320
gene id: 1437875:CFRA_RS02320
uniprot id: A0A1L7CR57
names: Similarity
messages: Belongs to the EfeM/EfeO family.

1437875:CFRA RS06825
gene id: 1437875:CFRA_RS06825
uniprot id: A0A1L7CT62
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02345
gene id: 1437875:CFRA_RS02345
uniprot id: A0A1L7CR39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1437875:CFRA RS02000
gene id: 1437875:CFRA_RS02000
uniprot id: A0A1L7CQY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1437875:CFRA RS04805
gene id: 1437875:CFRA_RS04805
uniprot id: A0A1L7CS72
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1437875:CFRA RS08265
gene id: 1437875:CFRA_RS08265
uniprot id: A0A1L7CTV8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1437875:CFRA RS05620
gene id: 1437875:CFRA_RS05620
uniprot id: A0A1L7CSJ3
names: Similarity
messages: Belongs to the UPF0098 family.

1437875:CFRA RS02265
gene id: 1437875:CFRA_RS02265
uniprot id: A0A1L7CR53
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1437875:CFRA RS06165
gene id: 1437875:CFRA_RS06165
uniprot id: A0A1L7CSU8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1437875:CFRA RS05000
gene id: 1437875:CFRA_RS05000
uniprot id: A0A1L7CSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1437875:CFRA RS04995
gene id: 1437875:CFRA_RS04995
uniprot id: A0A1L7CSA9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1437875:CFRA RS09430
gene id: 1437875:CFRA_RS09430
uniprot id: A0A1L7CUB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1437875:CFRA RS05530
gene id: 1437875:CFRA_RS05530
uniprot id: A0A1L7CSM1
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

1437875:CFRA RS07425
gene id: 1437875:CFRA_RS07425
uniprot id: A0A1L7CTP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1437875:CFRA RS05560
gene id: 1437875:CFRA_RS05560
uniprot id: A0A1L7CSJ4
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1437875:CFRA RS04735
gene id: 1437875:CFRA_RS04735
uniprot id: A0A1L7CSA8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS04615
gene id: 1437875:CFRA_RS04615
uniprot id: A0A1L7CS51
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1437875:CFRA RS06015
gene id: 1437875:CFRA_RS06015
uniprot id: A0A1L7CSS6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1437875:CFRA RS05490
gene id: 1437875:CFRA_RS05490
uniprot id: A0A1L7CSI4
names: Similarity
messages: Belongs to the FGGY kinase family.

1437875:CFRA RS09345
gene id: 1437875:CFRA_RS09345
uniprot id: A0A1L7CUE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS01160
gene id: 1437875:CFRA_RS01160
uniprot id: A0A1L7CQM5
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS08010
gene id: 1437875:CFRA_RS08010
uniprot id: A0A1L7CTT2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1437875:CFRA RS08090
gene id: 1437875:CFRA_RS08090
uniprot id: A0A1L7CTZ6
names: Similarity
messages: Belongs to the peptidase C40 family.

1437875:CFRA RS08425
gene id: 1437875:CFRA_RS08425
uniprot id: A0A1L7CU27
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1437875:CFRA RS10185
gene id: 1437875:CFRA_RS10185
uniprot id: A0A1L7CUP8
names: Similarity
messages: Belongs to the peptidase S13 family.

1437875:CFRA RS07870
gene id: 1437875:CFRA_RS07870
uniprot id: A0A1L7CTR4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

1437875:CFRA RS11225
gene id: 1437875:CFRA_RS11225
uniprot id: A0A1L7CV20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1437875:CFRA RS02150
gene id: 1437875:CFRA_RS02150
uniprot id: A0A1L7CR34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1437875:CFRA RS02435
gene id: 1437875:CFRA_RS02435
uniprot id: A0A1L7CR74
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1437875:CFRA RS02390
gene id: 1437875:CFRA_RS02390
uniprot id: A0A1L7CR66
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1437875:CFRA RS07090
gene id: 1437875:CFRA_RS07090
uniprot id: A0A1L7CTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1437875:CFRA RS06275
gene id: 1437875:CFRA_RS06275
uniprot id: A0A1L7CT44
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS03500
gene id: 1437875:CFRA_RS03500
uniprot id: A0A1L7CRM0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS07300
gene id: 1437875:CFRA_RS07300
uniprot id: A0A1L7CTC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1437875:CFRA RS03880
gene id: 1437875:CFRA_RS03880
uniprot id: A0A1L7CRW2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1437875:CFRA RS05360
gene id: 1437875:CFRA_RS05360
uniprot id: A0A1L7CSJ2
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1437875:CFRA RS08585
gene id: 1437875:CFRA_RS08585
uniprot id: A0A1L7CTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1437875:CFRA RS05290
gene id: 1437875:CFRA_RS05290
uniprot id: A0A1L7CSL3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02315
gene id: 1437875:CFRA_RS02315
uniprot id: A0A1L7CR46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1437875:CFRA RS01040
gene id: 1437875:CFRA_RS01040
uniprot id: A0A1L7CQL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1437875:CFRA RS01750
gene id: 1437875:CFRA_RS01750
uniprot id: A0A1L7CQU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1437875:CFRA RS06135
gene id: 1437875:CFRA_RS06135
uniprot id: A0A1L7CSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1437875:CFRA RS04810
gene id: 1437875:CFRA_RS04810
uniprot id: A0A1L7CS92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS03005
gene id: 1437875:CFRA_RS03005
uniprot id: A0A1L7CRE5
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1437875:CFRA RS02525
gene id: 1437875:CFRA_RS02525
uniprot id: A0A1L7CR69
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS03505
gene id: 1437875:CFRA_RS03505
uniprot id: A0A1L7CRM3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1437875:CFRA RS04800
gene id: 1437875:CFRA_RS04800
uniprot id: A0A1L7CS71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS07750
gene id: 1437875:CFRA_RS07750
uniprot id: A0A1L7CTP5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1437875:CFRA RS03885
gene id: 1437875:CFRA_RS03885
uniprot id: A0A1L7CRX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS03405
gene id: 1437875:CFRA_RS03405
uniprot id: A0A1L7CRM7
names: Similarity
messages: Belongs to the FPG family.

1437875:CFRA RS03600
gene id: 1437875:CFRA_RS03600
uniprot id: A0A1L7CRT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1437875:CFRA RS02565
gene id: 1437875:CFRA_RS02565
uniprot id: A0A1L7CRA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1437875:CFRA RS05480
gene id: 1437875:CFRA_RS05480
uniprot id: A0A1L7CSH3
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1437875:CFRA RS03190
gene id: 1437875:CFRA_RS03190
uniprot id: A0A1L7CRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1437875:CFRA RS05315
gene id: 1437875:CFRA_RS05315
uniprot id: A0A1L7CSE8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1437875:CFRA RS07075
gene id: 1437875:CFRA_RS07075
uniprot id: A0A1L7CT82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1437875:CFRA RS01790
gene id: 1437875:CFRA_RS01790
uniprot id: A0A1L7CQX1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1437875:CFRA RS02515
gene id: 1437875:CFRA_RS02515
uniprot id: A0A1L7CR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1437875:CFRA RS01640
gene id: 1437875:CFRA_RS01640
uniprot id: A0A1L7CQS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS03170
gene id: 1437875:CFRA_RS03170
uniprot id: A0A1L7CRK9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1437875:CFRA RS05650
gene id: 1437875:CFRA_RS05650
uniprot id: A0A1L7CSK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1437875:CFRA RS04160
gene id: 1437875:CFRA_RS04160
uniprot id: A0A1L7CRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1437875:CFRA RS06725
gene id: 1437875:CFRA_RS06725
uniprot id: A0A1L7CT43
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1437875:CFRA RS10040
gene id: 1437875:CFRA_RS10040
uniprot id: A0A1L7CUI8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02705
gene id: 1437875:CFRA_RS02705
uniprot id: A0A1L7CRC5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1437875:CFRA RS00120
gene id: 1437875:CFRA_RS00120
uniprot id: A0A1L7CQ81
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1437875:CFRA RS03610
gene id: 1437875:CFRA_RS03610
uniprot id: A0A1L7CRQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1437875:CFRA RS07240
gene id: 1437875:CFRA_RS07240
uniprot id: A0A1L7CTC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1437875:CFRA RS00375
gene id: 1437875:CFRA_RS00375
uniprot id: A0A1L7CQ99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

1437875:CFRA RS07355
gene id: 1437875:CFRA_RS07355
uniprot id: A0A1L7CTD3
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05385
gene id: 1437875:CFRA_RS05385
uniprot id: A0A1L7CSG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1437875:CFRA RS05165
gene id: 1437875:CFRA_RS05165
uniprot id: A0A1L7CSE3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1437875:CFRA RS01990
gene id: 1437875:CFRA_RS01990
uniprot id: A0A1L7CR01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1437875:CFRA RS05690
gene id: 1437875:CFRA_RS05690
uniprot id: A0A1L7CSS4
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS01095
gene id: 1437875:CFRA_RS01095
uniprot id: A0A1L7CQM6
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1437875:CFRA RS00505
gene id: 1437875:CFRA_RS00505
uniprot id: A0A1L7CQB9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1437875:CFRA RS04345
gene id: 1437875:CFRA_RS04345
uniprot id: A0A1L7CS22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1437875:CFRA RS05380
gene id: 1437875:CFRA_RS05380
uniprot id: A0A1L7CSE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1437875:CFRA RS07460
gene id: 1437875:CFRA_RS07460
uniprot id: A0A1L7CTG5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1437875:CFRA RS02855
gene id: 1437875:CFRA_RS02855
uniprot id: A0A1L7CRD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1437875:CFRA RS07505
gene id: 1437875:CFRA_RS07505
uniprot id: A0A1L7CTI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS06215
gene id: 1437875:CFRA_RS06215
uniprot id: A0A1L7CSU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1437875:CFRA RS00765
gene id: 1437875:CFRA_RS00765
uniprot id: A0A1L7CQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1437875:CFRA RS06630
gene id: 1437875:CFRA_RS06630
uniprot id: A0A1L7CT14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS05535
gene id: 1437875:CFRA_RS05535
uniprot id: A0A1L7CSI6
names: Similarity
messages: Belongs to the UPF0237 family.

1437875:CFRA RS08885
gene id: 1437875:CFRA_RS08885
uniprot id: A0A1L7CU66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1437875:CFRA RS09100
gene id: 1437875:CFRA_RS09100
uniprot id: A0A1L7CU65
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1437875:CFRA RS07070
gene id: 1437875:CFRA_RS07070
uniprot id: A0A1L7CT97
names: Similarity
messages: Belongs to the YciI family.

1437875:CFRA RS06815
gene id: 1437875:CFRA_RS06815
uniprot id: A0A1L7CTD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1437875:CFRA RS11290
gene id: 1437875:CFRA_RS11290
uniprot id: A0A1L7CV48
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1437875:CFRA RS01300
gene id: 1437875:CFRA_RS01300
uniprot id: A0A1L7CQP6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1437875:CFRA RS07115
gene id: 1437875:CFRA_RS07115
uniprot id: A0A1L7CTA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1437875:CFRA RS09815
gene id: 1437875:CFRA_RS09815
uniprot id: A0A1L7CUH3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1437875:CFRA RS11255
gene id: 1437875:CFRA_RS11255
uniprot id: A0A1L7CVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1437875:CFRA RS07305
gene id: 1437875:CFRA_RS07305
uniprot id: A0A1L7CTD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1437875:CFRA RS05270
gene id: 1437875:CFRA_RS05270
uniprot id: A0A1L7CSC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1437875:CFRA RS10250
gene id: 1437875:CFRA_RS10250
uniprot id: A0A1L7CUQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS11205
gene id: 1437875:CFRA_RS11205
uniprot id: A0A1L7CV70
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

1437875:CFRA RS08895
gene id: 1437875:CFRA_RS08895
uniprot id: A0A1L7CU72
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1437875:CFRA RS03465
gene id: 1437875:CFRA_RS03465
uniprot id: A0A1L7CRP5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1437875:CFRA RS00535
gene id: 1437875:CFRA_RS00535
uniprot id: A0A1L7CQB8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1437875:CFRA RS05605
gene id: 1437875:CFRA_RS05605
uniprot id: A0A1L7CSK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS04335
gene id: 1437875:CFRA_RS04335
uniprot id: A0A1L7CS44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1437875:CFRA RS00460
gene id: 1437875:CFRA_RS00460
uniprot id: A0A1L7CQ92
names: Similarity
messages: Belongs to the peptidase M20A family.

1437875:CFRA RS10800
gene id: 1437875:CFRA_RS10800
uniprot id: A0A1L7CV26
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1437875:CFRA RS06390
gene id: 1437875:CFRA_RS06390
uniprot id: A0A1L7CSZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1437875:CFRA RS05745
gene id: 1437875:CFRA_RS05745
uniprot id: A0A1L7CSM8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

1437875:CFRA RS06760
gene id: 1437875:CFRA_RS06760
uniprot id: A0A1L7CT58
names: Similarity
messages: Belongs to the UPF0045 family.

1437875:CFRA RS03180
gene id: 1437875:CFRA_RS03180
uniprot id: A0A1L7CRI0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

1437875:CFRA RS09615
gene id: 1437875:CFRA_RS09615
uniprot id: A0A1L7CUE2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1437875:CFRA RS09780
gene id: 1437875:CFRA_RS09780
uniprot id: A0A1L7CUJ4
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1437875:CFRA RS09460
gene id: 1437875:CFRA_RS09460
uniprot id: A0A1L7CUH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1437875:CFRA RS02080
gene id: 1437875:CFRA_RS02080
uniprot id: A0A1L7CR07
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS09985
gene id: 1437875:CFRA_RS09985
uniprot id: A0A1L7CUH8
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1437875:CFRA RS06480
gene id: 1437875:CFRA_RS06480
uniprot id: A0A1L7CSX8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1437875:CFRA RS02035
gene id: 1437875:CFRA_RS02035
uniprot id: A0A1L7CR18
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS00380
gene id: 1437875:CFRA_RS00380
uniprot id: A0A1L7CQA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

1437875:CFRA RS07725
gene id: 1437875:CFRA_RS07725
uniprot id: A0A1L7CTJ0
names: Similarity
messages: Belongs to the HupF/HypC family.

1437875:CFRA RS11215
gene id: 1437875:CFRA_RS11215
uniprot id: A0A1L7CV73
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00715
gene id: 1437875:CFRA_RS00715
uniprot id: A0A1L7CQG7
names: Similarity
messages: Belongs to the peptidase M13 family.

1437875:CFRA RS05275
gene id: 1437875:CFRA_RS05275
uniprot id: A0A1L7CSC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1437875:CFRA RS01045
gene id: 1437875:CFRA_RS01045
uniprot id: A0A1L7CQK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS03020
gene id: 1437875:CFRA_RS03020
uniprot id: A0A1L7CRG6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1437875:CFRA RS08555
gene id: 1437875:CFRA_RS08555
uniprot id: A0A1L7CU50
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1437875:CFRA RS01685
gene id: 1437875:CFRA_RS01685
uniprot id: A0A1L7CQU9
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS03680
gene id: 1437875:CFRA_RS03680
uniprot id: A0A1L7CRS5
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1437875:CFRA RS02735
gene id: 1437875:CFRA_RS02735
uniprot id: A0A1L7CRA4
names: Similarity
messages: Belongs to the citrate synthase family.

1437875:CFRA RS05345
gene id: 1437875:CFRA_RS05345
uniprot id: A0A1L7CSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1437875:CFRA RS07345
gene id: 1437875:CFRA_RS07345
uniprot id: A0A1L7CTE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1437875:CFRA RS01565
gene id: 1437875:CFRA_RS01565
uniprot id: A0A1L7CQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1437875:CFRA RS07760
gene id: 1437875:CFRA_RS07760
uniprot id: A0A1L7CTN2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

1437875:CFRA RS03670
gene id: 1437875:CFRA_RS03670
uniprot id: A0A1L7CRP9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

1437875:CFRA RS11080
gene id: 1437875:CFRA_RS11080
uniprot id: A0A1L7CV81
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS06550
gene id: 1437875:CFRA_RS06550
uniprot id: A0A1L7CT04
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1437875:CFRA RS03795
gene id: 1437875:CFRA_RS03795
uniprot id: A0A1L7CRS4
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1437875:CFRA RS10280
gene id: 1437875:CFRA_RS10280
uniprot id: A0A1L7CUU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1437875:CFRA RS05695
gene id: 1437875:CFRA_RS05695
uniprot id: A0A1L7CSN2
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1437875:CFRA RS09930
gene id: 1437875:CFRA_RS09930
uniprot id: A0A1L7CUP6
names: Similarity
messages: Belongs to the TPP enzyme family.

1437875:CFRA RS08170
gene id: 1437875:CFRA_RS08170
uniprot id: A0A1L7CTS0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1437875:CFRA RS07195
gene id: 1437875:CFRA_RS07195
uniprot id: A0A1L7CTD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS01895
gene id: 1437875:CFRA_RS01895
uniprot id: A0A1L7CQW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1437875:CFRA RS09455
gene id: 1437875:CFRA_RS09455
uniprot id: A0A1L7CUE4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1437875:CFRA RS08755
gene id: 1437875:CFRA_RS08755
uniprot id: A0A1L7CU08
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS03185
gene id: 1437875:CFRA_RS03185
uniprot id: A0A1L7CRH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1437875:CFRA RS05885
gene id: 1437875:CFRA_RS05885
uniprot id: A0A1L7CSR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

1437875:CFRA RS02200
gene id: 1437875:CFRA_RS02200
uniprot id: A0A1L7CR20
names: Similarity
messages: Belongs to the CFA/CMAS family.

1437875:CFRA RS00315
gene id: 1437875:CFRA_RS00315
uniprot id: A0A1L7CQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1437875:CFRA RS11150
gene id: 1437875:CFRA_RS11150
uniprot id: A0A1L7CV28
names: Similarity
messages: Belongs to the FPG family.

1437875:CFRA RS03585
gene id: 1437875:CFRA_RS03585
uniprot id: A0A1L7CRR3
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS07080
gene id: 1437875:CFRA_RS07080
uniprot id: A0A1L7CT91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Membrane

1437875:CFRA RS00990
gene id: 1437875:CFRA_RS00990
uniprot id: A0A1L7CQH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1437875:CFRA RS08110
gene id: 1437875:CFRA_RS08110
uniprot id: A0A1L7CTR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1437875:CFRA RS04320
gene id: 1437875:CFRA_RS04320
uniprot id: A0A1L7CS30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1437875:CFRA RS07795
gene id: 1437875:CFRA_RS07795
uniprot id: A0A1L7CTL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1437875:CFRA RS00465
gene id: 1437875:CFRA_RS00465
uniprot id: A0A1L7CQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS00260
gene id: 1437875:CFRA_RS00260
uniprot id: A0A1L7CQ64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1437875:CFRA RS07045
gene id: 1437875:CFRA_RS07045
uniprot id: A0A1L7CTB4
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS04270
gene id: 1437875:CFRA_RS04270
uniprot id: A0A1L7CRZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1437875:CFRA RS09820
gene id: 1437875:CFRA_RS09820
uniprot id: A0A1L7CUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1437875:CFRA RS05670
gene id: 1437875:CFRA_RS05670
uniprot id: A0A1L7CSK8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1437875:CFRA RS09035
gene id: 1437875:CFRA_RS09035
uniprot id: A0A1L7CU43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1437875:CFRA RS11085
gene id: 1437875:CFRA_RS11085
uniprot id: A0A1L7CV43
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1437875:CFRA RS08590
gene id: 1437875:CFRA_RS08590
uniprot id: A0A1L7CTX5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1437875:CFRA RS07410
gene id: 1437875:CFRA_RS07410
uniprot id: A0A1L7CTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS01590
gene id: 1437875:CFRA_RS01590
uniprot id: A0A1L7CQR8
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS09905
gene id: 1437875:CFRA_RS09905
uniprot id: A0A1L7CUL5
names: Similarity
messages: Belongs to the GARS family.

1437875:CFRA RS07270
gene id: 1437875:CFRA_RS07270
uniprot id: A0A1L7CTF9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1437875:CFRA RS07890
gene id: 1437875:CFRA_RS07890
uniprot id: A0A1L7CTM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

1437875:CFRA RS01455
gene id: 1437875:CFRA_RS01455
uniprot id: A0A1L7CQQ2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1437875:CFRA RS07945
gene id: 1437875:CFRA_RS07945
uniprot id: A0A1L7CTP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS01615
gene id: 1437875:CFRA_RS01615
uniprot id: A0A1L7CQT9
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1437875:CFRA RS05230
gene id: 1437875:CFRA_RS05230
uniprot id: A0A1L7CSD9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1437875:CFRA RS00360
gene id: 1437875:CFRA_RS00360
uniprot id: A0A1L7CQ86
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1437875:CFRA RS02250
gene id: 1437875:CFRA_RS02250
uniprot id: A0A1L7CR44
names: Similarity
messages: Belongs to the WXG100 family.

1437875:CFRA RS10335
gene id: 1437875:CFRA_RS10335
uniprot id: A0A1L7CUU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1437875:CFRA RS07895
gene id: 1437875:CFRA_RS07895
uniprot id: A0A1L7CTN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1437875:CFRA RS02780
gene id: 1437875:CFRA_RS02780
uniprot id: A0A1L7CRA9
names: Similarity
messages: Belongs to the AccD/PCCB family.

1437875:CFRA RS02455
gene id: 1437875:CFRA_RS02455
uniprot id: A0A1L7CR86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1437875:CFRA RS10925
gene id: 1437875:CFRA_RS10925
uniprot id: A0A1L7CV45
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS04310
gene id: 1437875:CFRA_RS04310
uniprot id: A0A1L7CS18
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1437875:CFRA RS02655
gene id: 1437875:CFRA_RS02655
uniprot id: A0A1L7CR91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS08125
gene id: 1437875:CFRA_RS08125
uniprot id: A0A1L7CTQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1437875:CFRA RS02055
gene id: 1437875:CFRA_RS02055
uniprot id: A0A1L7CQZ5
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05870
gene id: 1437875:CFRA_RS05870
uniprot id: A0A1L7CSP2
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

1437875:CFRA RS01845
gene id: 1437875:CFRA_RS01845
uniprot id: A0A1L7CQY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1437875:CFRA RS02925
gene id: 1437875:CFRA_RS02925
uniprot id: A0A1L7CRD7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1437875:CFRA RS04180
gene id: 1437875:CFRA_RS04180
uniprot id: A0A1L7CRZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1437875:CFRA RS09185
gene id: 1437875:CFRA_RS09185
uniprot id: A0A1L7CUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1437875:CFRA RS07630
gene id: 1437875:CFRA_RS07630
uniprot id: A0A1L7CTJ3
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS00025
gene id: 1437875:CFRA_RS00025
uniprot id: A0A1L7CQ65
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1437875:CFRA RS03195
gene id: 1437875:CFRA_RS03195
uniprot id: A0A1L7CRJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1437875:CFRA RS08595
gene id: 1437875:CFRA_RS08595
uniprot id: A0A1L7CTX8
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1437875:CFRA RS02085
gene id: 1437875:CFRA_RS02085
uniprot id: A0A1L7CR15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

1437875:CFRA RS02095
gene id: 1437875:CFRA_RS02095
uniprot id: A0A1L7CR00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1437875:CFRA RS09730
gene id: 1437875:CFRA_RS09730
uniprot id: A0A1L7CUI4
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1437875:CFRA RS03480
gene id: 1437875:CFRA_RS03480
uniprot id: A0A1L7CRM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1437875:CFRA RS03535
gene id: 1437875:CFRA_RS03535
uniprot id: A0A1L7CRN8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1437875:CFRA RS03495
gene id: 1437875:CFRA_RS03495
uniprot id: A0A1L7CRM9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1437875:CFRA RS10390
gene id: 1437875:CFRA_RS10390
uniprot id: A0A1L7CUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS02880
gene id: 1437875:CFRA_RS02880
uniprot id: A0A1L7CRF8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1437875:CFRA RS03010
gene id: 1437875:CFRA_RS03010
uniprot id: A0A1L7CRE4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1437875:CFRA RS08185
gene id: 1437875:CFRA_RS08185
uniprot id: A0A1L7CTS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1437875:CFRA RS02300
gene id: 1437875:CFRA_RS02300
uniprot id: A0A1L7CR19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

1437875:CFRA RS07865
gene id: 1437875:CFRA_RS07865
uniprot id: A0A1L7CTW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1437875:CFRA RS03075
gene id: 1437875:CFRA_RS03075
uniprot id: A0A1L7CRI4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1437875:CFRA RS09355
gene id: 1437875:CFRA_RS09355
uniprot id: A0A1L7CUA5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1437875:CFRA RS07405
gene id: 1437875:CFRA_RS07405
uniprot id: A0A1L7CTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS01985
gene id: 1437875:CFRA_RS01985
uniprot id: A0A1L7CQY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1437875:CFRA RS09850
gene id: 1437875:CFRA_RS09850
uniprot id: A0A1L7CUK4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1437875:CFRA RS09525
gene id: 1437875:CFRA_RS09525
uniprot id: A0A1L7CUK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1437875:CFRA RS01965
gene id: 1437875:CFRA_RS01965
uniprot id: A0A1L7CQX7
names: Similarity
messages: Belongs to the asp23 family.

1437875:CFRA RS04850
gene id: 1437875:CFRA_RS04850
uniprot id: A0A1L7CS96
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1437875:CFRA RS06175
gene id: 1437875:CFRA_RS06175
uniprot id: A0A1L7CSU1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1437875:CFRA RS01075
gene id: 1437875:CFRA_RS01075
uniprot id: A0A1L7CQL5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00920
gene id: 1437875:CFRA_RS00920
uniprot id: A0A1L7CQJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1437875:CFRA RS10200
gene id: 1437875:CFRA_RS10200
uniprot id: A0A1L7CUM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1437875:CFRA RS05410
gene id: 1437875:CFRA_RS05410
uniprot id: A0A1L7CSK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1437875:CFRA RS03350
gene id: 1437875:CFRA_RS03350
uniprot id: A0A1L7CRK8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1437875:CFRA RS10765
gene id: 1437875:CFRA_RS10765
uniprot id: A0A1L7CV29
names: Similarity
messages: Belongs to the mycobacterial A85 antigen family.

1437875:CFRA RS02730
gene id: 1437875:CFRA_RS02730
uniprot id: A0A1L7CR95
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

1437875:CFRA RS02165
gene id: 1437875:CFRA_RS02165
uniprot id: A0A1L7CR13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1437875:CFRA RS00150
gene id: 1437875:CFRA_RS00150
uniprot id: A0A1L7CQ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1437875:CFRA RS05990
gene id: 1437875:CFRA_RS05990
uniprot id: A0A1L7CST9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS08715
gene id: 1437875:CFRA_RS08715
uniprot id: A0A1L7CU80
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1437875:CFRA RS04015
gene id: 1437875:CFRA_RS04015
uniprot id: A0A1L7CRX5
names: Similarity
messages: Belongs to the FBPase class 2 family.

1437875:CFRA RS06605
gene id: 1437875:CFRA_RS06605
uniprot id: A0A1L7CT06
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1437875:CFRA RS07100
gene id: 1437875:CFRA_RS07100
uniprot id: A0A1L7CTB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS03540
gene id: 1437875:CFRA_RS03540
uniprot id: A0A1L7CRS1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1437875:CFRA RS05430
gene id: 1437875:CFRA_RS05430
uniprot id: A0A1L7CSG5
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02175
gene id: 1437875:CFRA_RS02175
uniprot id: A0A1L7CR12
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1437875:CFRA RS10405
gene id: 1437875:CFRA_RS10405
uniprot id: A0A1L7CUW8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS08560
gene id: 1437875:CFRA_RS08560
uniprot id: A0A1L7CU16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS04440
gene id: 1437875:CFRA_RS04440
uniprot id: A0A1L7CS37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1437875:CFRA RS01610
gene id: 1437875:CFRA_RS01610
uniprot id: A0A1L7CQS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1437875:CFRA RS01760
gene id: 1437875:CFRA_RS01760
uniprot id: A0A1L7CQW3
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1437875:CFRA RS07990
gene id: 1437875:CFRA_RS07990
uniprot id: A0A1L7CTY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1437875:CFRA RS02550
gene id: 1437875:CFRA_RS02550
uniprot id: A0A1L7CR92
names: Similarity
messages: Belongs to the class-I fumarase family.

1437875:CFRA RS09735
gene id: 1437875:CFRA_RS09735
uniprot id: A0A1L7CUI3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1437875:CFRA RS01370
gene id: 1437875:CFRA_RS01370
uniprot id: A0A1L7CQQ5
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1437875:CFRA RS06335
gene id: 1437875:CFRA_RS06335
uniprot id: A0A1L7CSZ5
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1437875:CFRA RS08570
gene id: 1437875:CFRA_RS08570
uniprot id: A0A1L7CU11
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06875
gene id: 1437875:CFRA_RS06875
uniprot id: A0A1L7CT85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS08960
gene id: 1437875:CFRA_RS08960
uniprot id: A0A1L7CU85
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1437875:CFRA RS07105
gene id: 1437875:CFRA_RS07105
uniprot id: A0A1L7CTD5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1437875:CFRA RS07910
gene id: 1437875:CFRA_RS07910
uniprot id: A0A1L7CTN3
names: Similarity
messages: Belongs to the YggT family.

1437875:CFRA RS04775
gene id: 1437875:CFRA_RS04775
uniprot id: A0A1L7CS95
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1437875:CFRA RS07285
gene id: 1437875:CFRA_RS07285
uniprot id: A0A1L7CTD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1437875:CFRA RS08495
gene id: 1437875:CFRA_RS08495
uniprot id: A0A1L7CU46
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1437875:CFRA RS10825
gene id: 1437875:CFRA_RS10825
uniprot id: A0A1L7CV01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1437875:CFRA RS10430
gene id: 1437875:CFRA_RS10430
uniprot id: A0A1L7CUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1437875:CFRA RS02330
gene id: 1437875:CFRA_RS02330
uniprot id: A0A1L7CR42
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

1437875:CFRA RS10000
gene id: 1437875:CFRA_RS10000
uniprot id: A0A1L7CUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS05115
gene id: 1437875:CFRA_RS05115
uniprot id: A0A1L7CSF6
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05280
gene id: 1437875:CFRA_RS05280
uniprot id: A0A1L7CSE7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00345
gene id: 1437875:CFRA_RS00345
uniprot id: A0A1L7CQ74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1437875:CFRA RS08210
gene id: 1437875:CFRA_RS08210
uniprot id: A0A1L7CTV2
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS09470
gene id: 1437875:CFRA_RS09470
uniprot id: A0A1L7CUJ6
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1437875:CFRA RS02260
gene id: 1437875:CFRA_RS02260
uniprot id: A0A1L7CR31
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1437875:CFRA RS07130
gene id: 1437875:CFRA_RS07130
uniprot id: A0A1L7CTA1
names: Similarity
messages: Belongs to the ribF family.

1437875:CFRA RS11335
gene id: 1437875:CFRA_RS11335
uniprot id: A0A1L7CV91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1437875:CFRA RS01915
gene id: 1437875:CFRA_RS01915
uniprot id: A0A1L7CQY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1437875:CFRA RS11165
gene id: 1437875:CFRA_RS11165
uniprot id: A0A1L7CV90
names: Similarity
messages: Belongs to the glutamate synthase family.

1437875:CFRA RS04795
gene id: 1437875:CFRA_RS04795
uniprot id: A0A1L7CS85
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

1437875:CFRA RS07915
gene id: 1437875:CFRA_RS07915
uniprot id: A0A1L7CTQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1437875:CFRA RS08970
gene id: 1437875:CFRA_RS08970
uniprot id: A0A1L7CU42
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1437875:CFRA RS02170
gene id: 1437875:CFRA_RS02170
uniprot id: A0A1L7CQZ9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1437875:CFRA RS06435
gene id: 1437875:CFRA_RS06435
uniprot id: A0A1L7CSY0
names: Similarity
messages: Belongs to the peptidase S33 family.

1437875:CFRA RS07820
gene id: 1437875:CFRA_RS07820
uniprot id: A0A1L7CTP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1437875:CFRA RS05800
gene id: 1437875:CFRA_RS05800
uniprot id: A0A1L7CSN4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS07955
gene id: 1437875:CFRA_RS07955
uniprot id: A0A1L7CTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1437875:CFRA RS04245
gene id: 1437875:CFRA_RS04245
uniprot id: A0A1L7CS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS06225
gene id: 1437875:CFRA_RS06225
uniprot id: A0A1L7CT34
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06500
gene id: 1437875:CFRA_RS06500
uniprot id: A0A1L7CT83
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02580
gene id: 1437875:CFRA_RS02580
uniprot id: A0A1L7CR84
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1437875:CFRA RS01720
gene id: 1437875:CFRA_RS01720
uniprot id: A0A1L7CQU1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1437875:CFRA RS05835
gene id: 1437875:CFRA_RS05835
uniprot id: A0A1L7CSQ6
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS04965
gene id: 1437875:CFRA_RS04965
uniprot id: A0A1L7CS90
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS03965
gene id: 1437875:CFRA_RS03965
uniprot id: A0A1L7CRY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS08175
gene id: 1437875:CFRA_RS08175
uniprot id: A0A1L7CTS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1437875:CFRA RS05510
gene id: 1437875:CFRA_RS05510
uniprot id: A0A1L7CSK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

1437875:CFRA RS08850
gene id: 1437875:CFRA_RS08850
uniprot id: A0A1L7CU30
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

1437875:CFRA RS00485
gene id: 1437875:CFRA_RS00485
uniprot id: A0A1L7CQB0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1437875:CFRA RS08225
gene id: 1437875:CFRA_RS08225
uniprot id: A0A1L7CTT4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1437875:CFRA RS03155
gene id: 1437875:CFRA_RS03155
uniprot id: A0A1L7CRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

1437875:CFRA RS10010
gene id: 1437875:CFRA_RS10010
uniprot id: A0A1L7CUS3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1437875:CFRA RS01505
gene id: 1437875:CFRA_RS01505
uniprot id: A0A1L7CQQ8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1437875:CFRA RS09675
gene id: 1437875:CFRA_RS09675
uniprot id: A0A1L7CUG8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1437875:CFRA RS00985
gene id: 1437875:CFRA_RS00985
uniprot id: A0A1L7CQI1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1437875:CFRA RS06370
gene id: 1437875:CFRA_RS06370
uniprot id: A0A1L7CSX0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1437875:CFRA RS09380
gene id: 1437875:CFRA_RS09380
uniprot id: A0A1L7CUC2
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

1437875:CFRA RS06800
gene id: 1437875:CFRA_RS06800
uniprot id: A0A1L7CT31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1437875:CFRA RS11070
gene id: 1437875:CFRA_RS11070
uniprot id: A0A1L7CV06
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1437875:CFRA RS05465
gene id: 1437875:CFRA_RS05465
uniprot id: A0A1L7CSL0
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1437875:CFRA RS11310
gene id: 1437875:CFRA_RS11310
uniprot id: A0A1L7CV46
names: Similarity
messages: Belongs to the ParB family.

1437875:CFRA RS06930
gene id: 1437875:CFRA_RS06930
uniprot id: A0A1L7CT95
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1437875:CFRA RS06645
gene id: 1437875:CFRA_RS06645
uniprot id: A0A1L7CT10
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1437875:CFRA RS08705
gene id: 1437875:CFRA_RS08705
uniprot id: A0A1L7CU04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1437875:CFRA RS06065
gene id: 1437875:CFRA_RS06065
uniprot id: A0A1L7CST4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1437875:CFRA RS08855
gene id: 1437875:CFRA_RS08855
uniprot id: A0A1L7CU19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1437875:CFRA RS02740
gene id: 1437875:CFRA_RS02740
uniprot id: A0A1L7CRC0
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1437875:CFRA RS00705
gene id: 1437875:CFRA_RS00705
uniprot id: A0A1L7CQE3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1437875:CFRA RS04880
gene id: 1437875:CFRA_RS04880
uniprot id: A0A1L7CSA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1437875:CFRA RS10165
gene id: 1437875:CFRA_RS10165
uniprot id: A0A1L7CUL6
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1437875:CFRA RS10060
gene id: 1437875:CFRA_RS10060
uniprot id: A0A1L7CUK8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1437875:CFRA RS02140
gene id: 1437875:CFRA_RS02140
uniprot id: A0A1L7CR38
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1437875:CFRA RS06115
gene id: 1437875:CFRA_RS06115
uniprot id: A0A1L7CSX7
names: Similarity
messages: Belongs to the UPF0434 family.

1437875:CFRA RS02575
gene id: 1437875:CFRA_RS02575
uniprot id: A0A1L7CR79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1437875:CFRA RS06235
gene id: 1437875:CFRA_RS06235
uniprot id: A0A1L7CSV9
names: Similarity
messages: Belongs to the universal stress protein A family.

1437875:CFRA RS07720
gene id: 1437875:CFRA_RS07720
uniprot id: A0A1L7CTK5
names: Similarity
messages: Belongs to the IMPACT family.

1437875:CFRA RS07470
gene id: 1437875:CFRA_RS07470
uniprot id: A0A1L7CTF1
names: Similarity
messages: Belongs to the P(II) protein family.

1437875:CFRA RS06270
gene id: 1437875:CFRA_RS06270
uniprot id: A0A1L7CSY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1437875:CFRA RS02010
gene id: 1437875:CFRA_RS02010
uniprot id: A0A1L7CQW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS02370
gene id: 1437875:CFRA_RS02370
uniprot id: A0A1L7CR64
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1437875:CFRA RS07225
gene id: 1437875:CFRA_RS07225
uniprot id: A0A1L7CTF4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1437875:CFRA RS04330
gene id: 1437875:CFRA_RS04330
uniprot id: A0A1L7CS09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

1437875:CFRA RS04835
gene id: 1437875:CFRA_RS04835
uniprot id: A0A1L7CSA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1437875:CFRA RS04725
gene id: 1437875:CFRA_RS04725
uniprot id: A0A1L7CS86
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1437875:CFRA RS04575
gene id: 1437875:CFRA_RS04575
uniprot id: A0A1L7CS46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS09540
gene id: 1437875:CFRA_RS09540
uniprot id: A0A1L7CUD5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1437875:CFRA RS03440
gene id: 1437875:CFRA_RS03440
uniprot id: A0A1L7CRL1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1437875:CFRA RS09000
gene id: 1437875:CFRA_RS09000
uniprot id: A0A1L7CU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

1437875:CFRA RS02360
gene id: 1437875:CFRA_RS02360
uniprot id: A0A1L7CR41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1437875:CFRA RS09485
gene id: 1437875:CFRA_RS09485
uniprot id: A0A1L7CUC5
names: Similarity
messages: Belongs to the peptidase S58 family.

1437875:CFRA RS08890
gene id: 1437875:CFRA_RS08890
uniprot id: A0A1L7CU77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS01595
gene id: 1437875:CFRA_RS01595
uniprot id: A0A1L7CQR9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS10295
gene id: 1437875:CFRA_RS10295
uniprot id: A0A1L7CUU8
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS08670
gene id: 1437875:CFRA_RS08670
uniprot id: A0A1L7CU33
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1437875:CFRA RS08730
gene id: 1437875:CFRA_RS08730
uniprot id: A0A1L7CU40
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1437875:CFRA RS06110
gene id: 1437875:CFRA_RS06110
uniprot id: A0A1L7CSU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS07510
gene id: 1437875:CFRA_RS07510
uniprot id: A0A1L7CTJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1437875:CFRA RS10175
gene id: 1437875:CFRA_RS10175
uniprot id: A0A1L7CUU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1437875:CFRA RS05330
gene id: 1437875:CFRA_RS05330
uniprot id: A0A1L7CSD3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1437875:CFRA RS10025
gene id: 1437875:CFRA_RS10025
uniprot id: A0A1L7CUN2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1437875:CFRA RS02120
gene id: 1437875:CFRA_RS02120
uniprot id: A0A1L7CQY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS08320
gene id: 1437875:CFRA_RS08320
uniprot id: A0A1L7CTU4
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1437875:CFRA RS07000
gene id: 1437875:CFRA_RS07000
uniprot id: A0A1L7CTB9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

1437875:CFRA RS03000
gene id: 1437875:CFRA_RS03000
uniprot id: A0A1L7CRF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS02945
gene id: 1437875:CFRA_RS02945
uniprot id: A0A1L7CRE0
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1437875:CFRA RS08385
gene id: 1437875:CFRA_RS08385
uniprot id: A0A1L7CTY0
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1437875:CFRA RS08975
gene id: 1437875:CFRA_RS08975
uniprot id: A0A1L7CU34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

1437875:CFRA RS08160
gene id: 1437875:CFRA_RS08160
uniprot id: A0A1L7CTV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1437875:CFRA RS06805
gene id: 1437875:CFRA_RS06805
uniprot id: A0A1L7CT40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1437875:CFRA RS02975
gene id: 1437875:CFRA_RS02975
uniprot id: A0A1L7CRG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1437875:CFRA RS08430
gene id: 1437875:CFRA_RS08430
uniprot id: A0A1L7CTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1437875:CFRA RS03305
gene id: 1437875:CFRA_RS03305
uniprot id: A0A1L7CRL3
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06780
gene id: 1437875:CFRA_RS06780
uniprot id: A0A1L7CT78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1437875:CFRA RS04625
gene id: 1437875:CFRA_RS04625
uniprot id: A0A1L7CS61
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1437875:CFRA RS03035
gene id: 1437875:CFRA_RS03035
uniprot id: A0A1L7CRF9
names: Similarity
messages: Belongs to the DEAD box helicase family.

1437875:CFRA RS04410
gene id: 1437875:CFRA_RS04410
uniprot id: A0A1L7CS31
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1437875:CFRA RS06790
gene id: 1437875:CFRA_RS06790
uniprot id: A0A1L7CT50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1437875:CFRA RS02160
gene id: 1437875:CFRA_RS02160
uniprot id: A0A1L7CR14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1437875:CFRA RS06420
gene id: 1437875:CFRA_RS06420
uniprot id: A0A1L7CSY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS06075
gene id: 1437875:CFRA_RS06075
uniprot id: A0A1L7CSS5
names: Similarity
messages: Belongs to the TlyA family.

1437875:CFRA RS10535
gene id: 1437875:CFRA_RS10535
uniprot id: A0A1L7CUW3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1437875:CFRA RS11185
gene id: 1437875:CFRA_RS11185
uniprot id: A0A1L7CV24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00500
gene id: 1437875:CFRA_RS00500
uniprot id: A0A1L7CQ89
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1437875:CFRA RS04265
gene id: 1437875:CFRA_RS04265
uniprot id: A0A1L7CS19
names: Cofactor
messages: Can also use Mn(2+) ion.

1437875:CFRA RS07905
gene id: 1437875:CFRA_RS07905
uniprot id: A0A1L7CTM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1437875:CFRA RS07515
gene id: 1437875:CFRA_RS07515
uniprot id: A0A1L7CTH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1437875:CFRA RS09165
gene id: 1437875:CFRA_RS09165
uniprot id: A0A1L7CU74
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1437875:CFRA RS02725
gene id: 1437875:CFRA_RS02725
uniprot id: A0A1L7CRA3
names: Similarity
messages: Belongs to the PrpD family.

1437875:CFRA RS00255
gene id: 1437875:CFRA_RS00255
uniprot id: A0A1L7CQ95
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1437875:CFRA RS02105
gene id: 1437875:CFRA_RS02105
uniprot id: A0A1L7CR16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1437875:CFRA RS06690
gene id: 1437875:CFRA_RS06690
uniprot id: A0A1L7CT28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS03460
gene id: 1437875:CFRA_RS03460
uniprot id: A0A1L7CRN7
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02015
gene id: 1437875:CFRA_RS02015
uniprot id: A0A1L7CQY3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1437875:CFRA RS01995
gene id: 1437875:CFRA_RS01995
uniprot id: A0A1L7CQZ6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1437875:CFRA RS10190
gene id: 1437875:CFRA_RS10190
uniprot id: A0A1L7CUP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1437875:CFRA RS05460
gene id: 1437875:CFRA_RS05460
uniprot id: A0A1L7CSG9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1437875:CFRA RS01920
gene id: 1437875:CFRA_RS01920
uniprot id: A0A1L7CQZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1437875:CFRA RS08235
gene id: 1437875:CFRA_RS08235
uniprot id: A0A1L7CTS2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1437875:CFRA RS05320
gene id: 1437875:CFRA_RS05320
uniprot id: A0A1L7CSF1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1437875:CFRA RS00430
gene id: 1437875:CFRA_RS00430
uniprot id: A0A1L7CQA3
names: Similarity
messages: Belongs to the HsdR family.

1437875:CFRA RS07050
gene id: 1437875:CFRA_RS07050
uniprot id: A0A1L7CTA5
names: Similarity
messages: Belongs to the PspA/IM30 family.

1437875:CFRA RS09290
gene id: 1437875:CFRA_RS09290
uniprot id: A0A1L7CU94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1437875:CFRA RS00870
gene id: 1437875:CFRA_RS00870
uniprot id: A0A1L7CQG2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1437875:CFRA RS07215
gene id: 1437875:CFRA_RS07215
uniprot id: A0A1L7CTD7
names: Similarity
messages: Belongs to the MQO family.

1437875:CFRA RS11050
gene id: 1437875:CFRA_RS11050
uniprot id: A0A1L7CUY9
names: Similarity
messages: Belongs to the PspA/IM30 family.

1437875:CFRA RS01490
gene id: 1437875:CFRA_RS01490
uniprot id: A0A1L7CQS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1437875:CFRA RS05355
gene id: 1437875:CFRA_RS05355
uniprot id: A0A1L7CSE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1437875:CFRA RS09445
gene id: 1437875:CFRA_RS09445
uniprot id: A0A1L7CUD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1437875:CFRA RS07580
gene id: 1437875:CFRA_RS07580
uniprot id: A0A1L7CTI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS08900
gene id: 1437875:CFRA_RS08900
uniprot id: A0A1L7CU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1437875:CFRA RS08435
gene id: 1437875:CFRA_RS08435
uniprot id: A0A1L7CTY2
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

1437875:CFRA RS05160
gene id: 1437875:CFRA_RS05160
uniprot id: A0A1L7CSJ7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1437875:CFRA RS05150
gene id: 1437875:CFRA_RS05150
uniprot id: A0A1L7CSD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS02070
gene id: 1437875:CFRA_RS02070
uniprot id: A0A1L7CQX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1437875:CFRA RS08055
gene id: 1437875:CFRA_RS08055
uniprot id: A0A1L7CTQ3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1437875:CFRA RS07430
gene id: 1437875:CFRA_RS07430
uniprot id: A0A1L7CTI8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1437875:CFRA RS08640
gene id: 1437875:CFRA_RS08640
uniprot id: A0A1L7CTY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1437875:CFRA RS06190
gene id: 1437875:CFRA_RS06190
uniprot id: A0A1L7CSV2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1437875:CFRA RS10725
gene id: 1437875:CFRA_RS10725
uniprot id: A0A1L7CUZ7
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS01265
gene id: 1437875:CFRA_RS01265
uniprot id: A0A1L7CQM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1437875:CFRA RS05040
gene id: 1437875:CFRA_RS05040
uniprot id: A0A1L7CSE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS02405
gene id: 1437875:CFRA_RS02405
uniprot id: A0A1L7CR49
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1437875:CFRA RS02020
gene id: 1437875:CFRA_RS02020
uniprot id: A0A1L7CQZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1437875:CFRA RS00640
gene id: 1437875:CFRA_RS00640
uniprot id: A0A1L7CQD4
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

1437875:CFRA RS05845
gene id: 1437875:CFRA_RS05845
uniprot id: A0A1L7CSS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS09800
gene id: 1437875:CFRA_RS09800
uniprot id: A0A1L7CUM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1437875:CFRA RS02640
gene id: 1437875:CFRA_RS02640
uniprot id: A0A1L7CRA1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1437875:CFRA RS02680
gene id: 1437875:CFRA_RS02680
uniprot id: A0A1L7CR94
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1437875:CFRA RS03790
gene id: 1437875:CFRA_RS03790
uniprot id: A0A1L7CRR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1437875:CFRA RS03425
gene id: 1437875:CFRA_RS03425
uniprot id: A0A1L7CRQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1437875:CFRA RS06240
gene id: 1437875:CFRA_RS06240
uniprot id: A0A1L7CSZ6
names: Similarity
messages: Belongs to the universal stress protein A family.

1437875:CFRA RS00595
gene id: 1437875:CFRA_RS00595
uniprot id: A0A1L7CQB5
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1437875:CFRA RS05685
gene id: 1437875:CFRA_RS05685
uniprot id: A0A1L7CSL9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02810
gene id: 1437875:CFRA_RS02810
uniprot id: A0A1L7CRC2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1437875:CFRA RS03800
gene id: 1437875:CFRA_RS03800
uniprot id: A0A1L7CRU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1437875:CFRA RS08765
gene id: 1437875:CFRA_RS08765
uniprot id: A0A1L7CU90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cell inner membrane
messages: Membrane

1437875:CFRA RS07930
gene id: 1437875:CFRA_RS07930
uniprot id: A0A1L7CTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1437875:CFRA RS11195
gene id: 1437875:CFRA_RS11195
uniprot id: A0A1L7CV98
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS06195
gene id: 1437875:CFRA_RS06195
uniprot id: A0A1L7CSV3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1437875:CFRA RS06665
gene id: 1437875:CFRA_RS06665
uniprot id: A0A1L7CT45
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02130
gene id: 1437875:CFRA_RS02130
uniprot id: A0A1L7CR17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1437875:CFRA RS10500
gene id: 1437875:CFRA_RS10500
uniprot id: A0A1L7CUX4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1437875:CFRA RS10715
gene id: 1437875:CFRA_RS10715
uniprot id: A0A1L7CUY5
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS09825
gene id: 1437875:CFRA_RS09825
uniprot id: A0A1L7CUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1437875:CFRA RS11145
gene id: 1437875:CFRA_RS11145
uniprot id: A0A1L7CV64
names: Similarity
messages: Belongs to the Dps family.

1437875:CFRA RS05120
gene id: 1437875:CFRA_RS05120
uniprot id: A0A1L7CSC0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1437875:CFRA RS05935
gene id: 1437875:CFRA_RS05935
uniprot id: A0A1L7CST0
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS07445
gene id: 1437875:CFRA_RS07445
uniprot id: A0A1L7CTH7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1437875:CFRA RS08575
gene id: 1437875:CFRA_RS08575
uniprot id: A0A1L7CTY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1437875:CFRA RS06590
gene id: 1437875:CFRA_RS06590
uniprot id: A0A1L7CT51
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1437875:CFRA RS02385
gene id: 1437875:CFRA_RS02385
uniprot id: A0A1L7CR76
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1437875:CFRA RS02075
gene id: 1437875:CFRA_RS02075
uniprot id: A0A1L7CQZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1437875:CFRA RS07500
gene id: 1437875:CFRA_RS07500
uniprot id: A0A1L7CTK1
names: Similarity
messages: Belongs to the acylphosphatase family.

1437875:CFRA RS11075
gene id: 1437875:CFRA_RS11075
uniprot id: A0A1L7CV88
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1437875:CFRA RS09740
gene id: 1437875:CFRA_RS09740
uniprot id: A0A1L7CUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1437875:CFRA RS07120
gene id: 1437875:CFRA_RS07120
uniprot id: A0A1L7CTA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1437875:CFRA RS01925
gene id: 1437875:CFRA_RS01925
uniprot id: A0A1L7CQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1437875:CFRA RS07165
gene id: 1437875:CFRA_RS07165
uniprot id: A0A1L7CTB5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1437875:CFRA RS05665
gene id: 1437875:CFRA_RS05665
uniprot id: A0A1L7CSL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1437875:CFRA RS04080
gene id: 1437875:CFRA_RS04080
uniprot id: A0A1L7CRW7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1437875:CFRA RS05970
gene id: 1437875:CFRA_RS05970
uniprot id: A0A1L7CSQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1437875:CFRA RS01660
gene id: 1437875:CFRA_RS01660
uniprot id: A0A1L7CQT0
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS07925
gene id: 1437875:CFRA_RS07925
uniprot id: A0A1L7CTS4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1437875:CFRA RS09560
gene id: 1437875:CFRA_RS09560
uniprot id: A0A1L7CUJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1437875:CFRA RS05675
gene id: 1437875:CFRA_RS05675
uniprot id: A0A1L7CSJ5
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1437875:CFRA RS03855
gene id: 1437875:CFRA_RS03855
uniprot id: A0A1L7CRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

1437875:CFRA RS01850
gene id: 1437875:CFRA_RS01850
uniprot id: A0A1L7CQV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1437875:CFRA RS08530
gene id: 1437875:CFRA_RS08530
uniprot id: A0A1L7CTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS08325
gene id: 1437875:CFRA_RS08325
uniprot id: A0A1L7CTT0
names: Similarity
messages: Belongs to the glutamine synthetase family.

1437875:CFRA RS00140
gene id: 1437875:CFRA_RS00140
uniprot id: A0A1L7CQ66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1437875:CFRA RS07380
gene id: 1437875:CFRA_RS07380
uniprot id: A0A1L7CTI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1437875:CFRA RS02355
gene id: 1437875:CFRA_RS02355
uniprot id: A0A1L7CR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1437875:CFRA RS09660
gene id: 1437875:CFRA_RS09660
uniprot id: A0A1L7CUK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS06475
gene id: 1437875:CFRA_RS06475
uniprot id: A0A1L7CSZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1437875:CFRA RS09890
gene id: 1437875:CFRA_RS09890
uniprot id: A0A1L7CUJ5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1437875:CFRA RS10130
gene id: 1437875:CFRA_RS10130
uniprot id: A0A1L7CUJ8
names: Similarity
messages: Belongs to the pantothenate synthetase family.

1437875:CFRA RS05010
gene id: 1437875:CFRA_RS05010
uniprot id: A0A1L7CSH5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1437875:CFRA RS04520
gene id: 1437875:CFRA_RS04520
uniprot id: A0A1L7CS17
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05260
gene id: 1437875:CFRA_RS05260
uniprot id: A0A1L7CSD8
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1437875:CFRA RS10940
gene id: 1437875:CFRA_RS10940
uniprot id: A0A1L7CUY6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1437875:CFRA RS05400
gene id: 1437875:CFRA_RS05400
uniprot id: A0A1L7CSI5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS04760
gene id: 1437875:CFRA_RS04760
uniprot id: A0A1L7CS83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1437875:CFRA RS06070
gene id: 1437875:CFRA_RS06070
uniprot id: A0A1L7CSQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS07735
gene id: 1437875:CFRA_RS07735
uniprot id: A0A1L7CTN0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1437875:CFRA RS07095
gene id: 1437875:CFRA_RS07095
uniprot id: A0A1L7CTC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1437875:CFRA RS06795
gene id: 1437875:CFRA_RS06795
uniprot id: A0A1L7CT46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1437875:CFRA RS11060
gene id: 1437875:CFRA_RS11060
uniprot id: A0A1L7CV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS07280
gene id: 1437875:CFRA_RS07280
uniprot id: A0A1L7CTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1437875:CFRA RS10160
gene id: 1437875:CFRA_RS10160
uniprot id: A0A1L7CUS2
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

1437875:CFRA RS10180
gene id: 1437875:CFRA_RS10180
uniprot id: A0A1L7CUS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1437875:CFRA RS06495
gene id: 1437875:CFRA_RS06495
uniprot id: A0A1L7CT20
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS09190
gene id: 1437875:CFRA_RS09190
uniprot id: A0A1L7CUB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS01930
gene id: 1437875:CFRA_RS01930
uniprot id: A0A1L7CQZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1437875:CFRA RS01450
gene id: 1437875:CFRA_RS01450
uniprot id: A0A1L7CQR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

1437875:CFRA RS08510
gene id: 1437875:CFRA_RS08510
uniprot id: A0A1L7CU00
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1437875:CFRA RS01755
gene id: 1437875:CFRA_RS01755
uniprot id: A0A1L7CQW1
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS02695
gene id: 1437875:CFRA_RS02695
uniprot id: A0A1L7CRC8
names: Similarity
messages: Belongs to the peptidase C40 family.

1437875:CFRA RS10015
gene id: 1437875:CFRA_RS10015
uniprot id: A0A1L7CUK7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS03275
gene id: 1437875:CFRA_RS03275
uniprot id: A0A1L7CRK6
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1437875:CFRA RS04185
gene id: 1437875:CFRA_RS04185
uniprot id: A0A1L7CS04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

1437875:CFRA RS09075
gene id: 1437875:CFRA_RS09075
uniprot id: A0A1L7CU92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1437875:CFRA RS05720
gene id: 1437875:CFRA_RS05720
uniprot id: A0A1L7CSL2
names: Similarity
messages: Belongs to the peptidase M18 family.

1437875:CFRA RS06720
gene id: 1437875:CFRA_RS06720
uniprot id: A0A1L7CT55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1437875:CFRA RS09750
gene id: 1437875:CFRA_RS09750
uniprot id: A0A1L7CUL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1437875:CFRA RS07025
gene id: 1437875:CFRA_RS07025
uniprot id: A0A1L7CT72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1437875:CFRA RS01705
gene id: 1437875:CFRA_RS01705
uniprot id: A0A1L7CQW0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1437875:CFRA RS04655
gene id: 1437875:CFRA_RS04655
uniprot id: A0A1L7CS66
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1437875:CFRA RS01355
gene id: 1437875:CFRA_RS01355
uniprot id: A0A1L7CQN1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1437875:CFRA RS03845
gene id: 1437875:CFRA_RS03845
uniprot id: A0A1L7CRU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1437875:CFRA RS02065
gene id: 1437875:CFRA_RS02065
uniprot id: A0A1L7CQZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1437875:CFRA RS05365
gene id: 1437875:CFRA_RS05365
uniprot id: A0A1L7CSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

1437875:CFRA RS02110
gene id: 1437875:CFRA_RS02110
uniprot id: A0A1L7CR05
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1437875:CFRA RS03340
gene id: 1437875:CFRA_RS03340
uniprot id: A0A1L7CRM4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1437875:CFRA RS06130
gene id: 1437875:CFRA_RS06130
uniprot id: A0A1L7CSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1437875:CFRA RS10235
gene id: 1437875:CFRA_RS10235
uniprot id: A0A1L7CUT8
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS05405
gene id: 1437875:CFRA_RS05405
uniprot id: A0A1L7CSF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1437875:CFRA RS00845
gene id: 1437875:CFRA_RS00845
uniprot id: A0A1L7CQG8
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS10530
gene id: 1437875:CFRA_RS10530
uniprot id: A0A1L7CUV6
names: Caution
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS06125
gene id: 1437875:CFRA_RS06125
uniprot id: A0A1L7CSU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS09765
gene id: 1437875:CFRA_RS09765
uniprot id: A0A1L7CUN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1437875:CFRA RS11130
gene id: 1437875:CFRA_RS11130
uniprot id: A0A1L7CV89
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1437875:CFRA RS04000
gene id: 1437875:CFRA_RS04000
uniprot id: A0A1L7CRU9
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS04705
gene id: 1437875:CFRA_RS04705
uniprot id: A0A1L7CS73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1437875:CFRA RS07005
gene id: 1437875:CFRA_RS07005
uniprot id: A0A1L7CT77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS01560
gene id: 1437875:CFRA_RS01560
uniprot id: A0A1L7CQT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS03110
gene id: 1437875:CFRA_RS03110
uniprot id: A0A1L7CRI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

1437875:CFRA RS05930
gene id: 1437875:CFRA_RS05930
uniprot id: A0A1L7CSY3
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS11010
gene id: 1437875:CFRA_RS11010
uniprot id: A0A1L7CV67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1437875:CFRA RS07965
gene id: 1437875:CFRA_RS07965
uniprot id: A0A1L7CTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1437875:CFRA RS11870
gene id: 1437875:CFRA_RS11870
uniprot id: A0A1L7CT42
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS03755
gene id: 1437875:CFRA_RS03755
uniprot id: A0A1L7CRV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS06320
gene id: 1437875:CFRA_RS06320
uniprot id: A0A1L7CSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1437875:CFRA RS03325
gene id: 1437875:CFRA_RS03325
uniprot id: A0A1L7CRJ1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1437875:CFRA RS03690
gene id: 1437875:CFRA_RS03690
uniprot id: A0A1L7CRT3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1437875:CFRA RS07530
gene id: 1437875:CFRA_RS07530
uniprot id: A0A1L7CTG1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1437875:CFRA RS05375
gene id: 1437875:CFRA_RS05375
uniprot id: A0A1L7CSF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1437875:CFRA RS10740
gene id: 1437875:CFRA_RS10740
uniprot id: A0A1L7CV13
names: Similarity
messages: Belongs to the AccD/PCCB family.

1437875:CFRA RS04700
gene id: 1437875:CFRA_RS04700
uniprot id: A0A1L7CS52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1437875:CFRA RS07260
gene id: 1437875:CFRA_RS07260
uniprot id: A0A1L7CTK9
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS02485
gene id: 1437875:CFRA_RS02485
uniprot id: A0A1L7CR77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1437875:CFRA RS08215
gene id: 1437875:CFRA_RS08215
uniprot id: A0A1L7CTW0
names: Similarity
messages: Belongs to the glutamine synthetase family.

1437875:CFRA RS00620
gene id: 1437875:CFRA_RS00620
uniprot id: A0A1L7CQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS09620
gene id: 1437875:CFRA_RS09620
uniprot id: A0A1L7CUE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS07135
gene id: 1437875:CFRA_RS07135
uniprot id: A0A1L7CTC9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1437875:CFRA RS01280
gene id: 1437875:CFRA_RS01280
uniprot id: A0A1L7CQL3
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

1437875:CFRA RS09025
gene id: 1437875:CFRA_RS09025
uniprot id: A0A1L7CU97
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1437875:CFRA RS04665
gene id: 1437875:CFRA_RS04665
uniprot id: A0A1L7CS77
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1437875:CFRA RS02100
gene id: 1437875:CFRA_RS02100
uniprot id: A0A1L7CR25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1437875:CFRA RS07360
gene id: 1437875:CFRA_RS07360
uniprot id: A0A1L7CTE3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1437875:CFRA RS03925
gene id: 1437875:CFRA_RS03925
uniprot id: A0A1L7CRV0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1437875:CFRA RS10510
gene id: 1437875:CFRA_RS10510
uniprot id: A0A1L7CUR9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1437875:CFRA RS03685
gene id: 1437875:CFRA_RS03685
uniprot id: A0A1L7CRS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1437875:CFRA RS06860
gene id: 1437875:CFRA_RS06860
uniprot id: A0A1L7CT48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1437875:CFRA RS04290
gene id: 1437875:CFRA_RS04290
uniprot id: A0A1L7CS02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1437875:CFRA RS06245
gene id: 1437875:CFRA_RS06245
uniprot id: A0A1L7CSV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1437875:CFRA RS07585
gene id: 1437875:CFRA_RS07585
uniprot id: A0A1L7CTH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1437875:CFRA RS09215
gene id: 1437875:CFRA_RS09215
uniprot id: A0A1L7CU79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1437875:CFRA RS05335
gene id: 1437875:CFRA_RS05335
uniprot id: A0A1L7CSF7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1437875:CFRA RS07175
gene id: 1437875:CFRA_RS07175
uniprot id: A0A1L7CTA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1437875:CFRA RS05645
gene id: 1437875:CFRA_RS05645
uniprot id: A0A1L7CSM4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1437875:CFRA RS03390
gene id: 1437875:CFRA_RS03390
uniprot id: A0A1L7CRK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS01385
gene id: 1437875:CFRA_RS01385
uniprot id: A0A1L7CQR3
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1437875:CFRA RS06160
gene id: 1437875:CFRA_RS06160
uniprot id: A0A1L7CSW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1437875:CFRA RS08680
gene id: 1437875:CFRA_RS08680
uniprot id: A0A1L7CU32
names: Subcellular Location Annotation
messages: Membrane

1437875:CFRA RS08135
gene id: 1437875:CFRA_RS08135
uniprot id: A0A1L7CTU0
names: Similarity
messages: Belongs to the asparagine synthetase family.

1437875:CFRA RS06430
gene id: 1437875:CFRA_RS06430
uniprot id: A0A1L7CSX1
names: Similarity
messages: Belongs to the isochorismate synthase family.

1437875:CFRA RS09550
gene id: 1437875:CFRA_RS09550
uniprot id: A0A1L7CUF0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1437875:CFRA RS10215
gene id: 1437875:CFRA_RS10215
uniprot id: A0A1L7CUT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1437875:CFRA RS02155
gene id: 1437875:CFRA_RS02155
uniprot id: A0A1L7CR26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1437875:CFRA RS08920
gene id: 1437875:CFRA_RS08920
uniprot id: A0A1L7CU36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1437875:CFRA RS11340
gene id: 1437875:CFRA_RS11340
uniprot id: A0A1L7CV96
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1437875:CFRA RS06525
gene id: 1437875:CFRA_RS06525
uniprot id: A0A1L7CT12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS00885
gene id: 1437875:CFRA_RS00885
uniprot id: A0A1L7CQJ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1437875:CFRA RS07780
gene id: 1437875:CFRA_RS07780
uniprot id: A0A1L7CTL5
names: Similarity
messages: Belongs to the HupF/HypC family.

1437875:CFRA RS09125
gene id: 1437875:CFRA_RS09125
uniprot id: A0A1L7CU98
names: Similarity
messages: Belongs to the peptidase M1 family.

1437875:CFRA RS09270
gene id: 1437875:CFRA_RS09270
uniprot id: A0A1L7CUC1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1437875:CFRA RS02995
gene id: 1437875:CFRA_RS02995
uniprot id: A0A1L7CRG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1437875:CFRA RS01425
gene id: 1437875:CFRA_RS01425
uniprot id: A0A1L7CQR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1437875:CFRA RS05125
gene id: 1437875:CFRA_RS05125
uniprot id: A0A1L7CSC1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1437875:CFRA RS04010
gene id: 1437875:CFRA_RS04010
uniprot id: A0A1L7CRV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1437875:CFRA RS07920
gene id: 1437875:CFRA_RS07920
uniprot id: A0A1L7CTX3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1437875:CFRA RS10945
gene id: 1437875:CFRA_RS10945
uniprot id: A0A1L7CV71
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1437875:CFRA RS07065
gene id: 1437875:CFRA_RS07065
uniprot id: A0A1L7CT96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1437875:CFRA RS09545
gene id: 1437875:CFRA_RS09545
uniprot id: A0A1L7CUD3
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1437875:CFRA RS04135
gene id: 1437875:CFRA_RS04135
uniprot id: A0A1L7CRZ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1437875:CFRA RS10290
gene id: 1437875:CFRA_RS10290
uniprot id: A0A1L7CUW2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1437875:CFRA RS07480
gene id: 1437875:CFRA_RS07480
uniprot id: A0A1L7CTG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1437875:CFRA RS02940
gene id: 1437875:CFRA_RS02940
uniprot id: A0A1L7CRF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1437875:CFRA RS08115
gene id: 1437875:CFRA_RS08115
uniprot id: A0A1L7CTQ9
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1437875:CFRA RS07770
gene id: 1437875:CFRA_RS07770
uniprot id: A0A1L7CTL6
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1437875:CFRA RS06810
gene id: 1437875:CFRA_RS06810
uniprot id: A0A1L7CT69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane