1434123:MSVAZ RS08265
gene id: 1434123:MSVAZ_RS08265
uniprot id: A0A0E3LH85
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS05085
gene id: 1434123:MSVAZ_RS05085
uniprot id: A0A0E3Q1W7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434123:MSVAZ RS10270
gene id: 1434123:MSVAZ_RS10270
uniprot id: A0A0E3Q686
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1434123:MSVAZ RS05710
gene id: 1434123:MSVAZ_RS05710
uniprot id: A0A0E3LGY9
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS13045
gene id: 1434123:MSVAZ_RS13045
uniprot id: A0A0E3Q7W0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS16065
gene id: 1434123:MSVAZ_RS16065
uniprot id: A0A0E3Q6Q3
names: Function
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

1434123:MSVAZ RS12385
gene id: 1434123:MSVAZ_RS12385
uniprot id: A0A0E3Q543
names: Similarity
messages: Belongs to the UPF0758 family.

1434123:MSVAZ RS03880
gene id: 1434123:MSVAZ_RS03880
uniprot id: A0A0E3Q341
names: Similarity
messages: Belongs to the MtxX family.

1434123:MSVAZ RS11220
gene id: 1434123:MSVAZ_RS11220
uniprot id: A0A0E3Q6M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1434123:MSVAZ RS07785
gene id: 1434123:MSVAZ_RS07785
uniprot id: A0A0E3LH67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434123:MSVAZ RS04990
gene id: 1434123:MSVAZ_RS04990
uniprot id: A0A0E3Q3Z7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1434123:MSVAZ RS16910
gene id: 1434123:MSVAZ_RS16910
uniprot id: A0A0E3Q9K6
names: Similarity
messages: Belongs to the UPF0215 family.

1434123:MSVAZ RS12715
gene id: 1434123:MSVAZ_RS12715
uniprot id: A0A0E3LHQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1434123:MSVAZ RS11095
gene id: 1434123:MSVAZ_RS11095
uniprot id: A0A0E3LHJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS12835
gene id: 1434123:MSVAZ_RS12835
uniprot id: A0A0E3Q799
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1434123:MSVAZ RS16630
gene id: 1434123:MSVAZ_RS16630
uniprot id: A0A0E3Q700
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS16380
gene id: 1434123:MSVAZ_RS16380
uniprot id: A0A0E3Q6V6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1434123:MSVAZ RS03660
gene id: 1434123:MSVAZ_RS03660
uniprot id: A0A0E3Q3G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

1434123:MSVAZ RS07260
gene id: 1434123:MSVAZ_RS07260
uniprot id: A0A0E3Q5G1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS12325
gene id: 1434123:MSVAZ_RS12325
uniprot id: A0A0E3Q725
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1434123:MSVAZ RS16555
gene id: 1434123:MSVAZ_RS16555
uniprot id: A0A0E3Q8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1434123:MSVAZ RS13770
gene id: 1434123:MSVAZ_RS13770
uniprot id: A0A0E3Q7P2
names: Similarity
messages: Belongs to the HupF/HypC family.

1434123:MSVAZ RS01940
gene id: 1434123:MSVAZ_RS01940
uniprot id: A0A0E3Q2Q4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS00055
gene id: 1434123:MSVAZ_RS00055
uniprot id: A0A0E3Q280
names: Similarity
messages: Belongs to the peptidase C1 family.

1434123:MSVAZ RS10795
gene id: 1434123:MSVAZ_RS10795
uniprot id: A0A0E3Q6G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1434123:MSVAZ RS13500
gene id: 1434123:MSVAZ_RS13500
uniprot id: A0A0E3Q7I3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1434123:MSVAZ RS06845
gene id: 1434123:MSVAZ_RS06845
uniprot id: A0A0E3Q4R6
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS05325
gene id: 1434123:MSVAZ_RS05325
uniprot id: A0A0E3Q3Q5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1434123:MSVAZ RS09800
gene id: 1434123:MSVAZ_RS09800
uniprot id: A0A0E3Q5Y7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1434123:MSVAZ RS06380
gene id: 1434123:MSVAZ_RS06380
uniprot id: A0A0E3LH14
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS13630
gene id: 1434123:MSVAZ_RS13630
uniprot id: A0A0E3Q7M3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1434123:MSVAZ RS07790
gene id: 1434123:MSVAZ_RS07790
uniprot id: A0A0E3Q5N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434123:MSVAZ RS09245
gene id: 1434123:MSVAZ_RS09245
uniprot id: A0A0E3Q5F8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS04125
gene id: 1434123:MSVAZ_RS04125
uniprot id: A0A0E3Q379
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1434123:MSVAZ RS01540
gene id: 1434123:MSVAZ_RS01540
uniprot id: A0A0E3Q2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS05440
gene id: 1434123:MSVAZ_RS05440
uniprot id: A0A0E3Q431
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1434123:MSVAZ RS17285
gene id: 1434123:MSVAZ_RS17285
uniprot id: A0A0E3LI76
names: Similarity
messages: Belongs to the AOR/FOR family.

1434123:MSVAZ RS12620
gene id: 1434123:MSVAZ_RS12620
uniprot id: A0A0E3Q729
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS02855
gene id: 1434123:MSVAZ_RS02855
uniprot id: A0A0E3Q320
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1434123:MSVAZ RS16225
gene id: 1434123:MSVAZ_RS16225
uniprot id: A0A0E3LI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Gas vesicle
messages: Vesicle

1434123:MSVAZ RS11510
gene id: 1434123:MSVAZ_RS11510
uniprot id: A0A0E3Q6R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1434123:MSVAZ RS04570
gene id: 1434123:MSVAZ_RS04570
uniprot id: A0A0E3LGU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1434123:MSVAZ RS04720
gene id: 1434123:MSVAZ_RS04720
uniprot id: A0A0E3Q4C8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1434123:MSVAZ RS00820
gene id: 1434123:MSVAZ_RS00820
uniprot id: A0A0E3LGF3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434123:MSVAZ RS12780
gene id: 1434123:MSVAZ_RS12780
uniprot id: A0A0E3Q790
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS13235
gene id: 1434123:MSVAZ_RS13235
uniprot id: A0A0E3Q7F0
names: Similarity
messages: Belongs to the UPF0173 family.

1434123:MSVAZ RS18735
gene id: 1434123:MSVAZ_RS18735
uniprot id: A0A0E3Q4N4
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1434123:MSVAZ RS15530
gene id: 1434123:MSVAZ_RS15530
uniprot id: A0A0E3LI08
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

1434123:MSVAZ RS15355
gene id: 1434123:MSVAZ_RS15355
uniprot id: A0A0E3LI01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS17640
gene id: 1434123:MSVAZ_RS17640
uniprot id: A0A0E3Q7H6
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1434123:MSVAZ RS02970
gene id: 1434123:MSVAZ_RS02970
uniprot id: A0A0E3Q2N5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1434123:MSVAZ RS09080
gene id: 1434123:MSVAZ_RS09080
uniprot id: A0A0E3Q5D2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1434123:MSVAZ RS14205
gene id: 1434123:MSVAZ_RS14205
uniprot id: A0A0E3LHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1434123:MSVAZ RS18345
gene id: 1434123:MSVAZ_RS18345
uniprot id: A0A0E3LIB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS15930
gene id: 1434123:MSVAZ_RS15930
uniprot id: A0A0E3Q892
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS03875
gene id: 1434123:MSVAZ_RS03875
uniprot id: A0A0E3Q3F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1434123:MSVAZ RS04660
gene id: 1434123:MSVAZ_RS04660
uniprot id: A0A0E3Q4B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1434123:MSVAZ RS10125
gene id: 1434123:MSVAZ_RS10125
uniprot id: A0A0E3Q632
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS13615
gene id: 1434123:MSVAZ_RS13615
uniprot id: A0A0E3Q7F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1434123:MSVAZ RS06490
gene id: 1434123:MSVAZ_RS06490
uniprot id: A0A0E3Q4L8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS17455
gene id: 1434123:MSVAZ_RS17455
uniprot id: A0A0E3LI82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS04120
gene id: 1434123:MSVAZ_RS04120
uniprot id: A0A0E3Q3I7
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434123:MSVAZ RS02960
gene id: 1434123:MSVAZ_RS02960
uniprot id: A0A0E3Q3H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1434123:MSVAZ RS12825
gene id: 1434123:MSVAZ_RS12825
uniprot id: A0A0E3Q730
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

1434123:MSVAZ RS16825
gene id: 1434123:MSVAZ_RS16825
uniprot id: A0A0E3Q764
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1434123:MSVAZ RS08045
gene id: 1434123:MSVAZ_RS08045
uniprot id: A0A0E3Q385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

1434123:MSVAZ RS15580
gene id: 1434123:MSVAZ_RS15580
uniprot id: A0A0E3Q8I2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434123:MSVAZ RS04915
gene id: 1434123:MSVAZ_RS04915
uniprot id: A0A0E3LGV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS02115
gene id: 1434123:MSVAZ_RS02115
uniprot id: A0A0E3Q2P3
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1434123:MSVAZ RS01490
gene id: 1434123:MSVAZ_RS01490
uniprot id: A0A0E3Q2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

1434123:MSVAZ RS06755
gene id: 1434123:MSVAZ_RS06755
uniprot id: A0A0E3Q553
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1434123:MSVAZ RS00485
gene id: 1434123:MSVAZ_RS00485
uniprot id: A0A0E3Q2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1434123:MSVAZ RS11830
gene id: 1434123:MSVAZ_RS11830
uniprot id: A0A0E3LHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434123:MSVAZ RS18745
gene id: 1434123:MSVAZ_RS18745
uniprot id: A0A0E3Q500
names: Similarity
messages: Belongs to the peptidase C40 family.

1434123:MSVAZ RS00060
gene id: 1434123:MSVAZ_RS00060
uniprot id: A0A0E3Q1T6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434123:MSVAZ RS01465
gene id: 1434123:MSVAZ_RS01465
uniprot id: A0A0E3Q205
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1434123:MSVAZ RS08595
gene id: 1434123:MSVAZ_RS08595
uniprot id: A0A0E3LH97
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1434123:MSVAZ RS17190
gene id: 1434123:MSVAZ_RS17190
uniprot id: A0A0E3LI72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS09630
gene id: 1434123:MSVAZ_RS09630
uniprot id: A0A0E3Q3X6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434123:MSVAZ RS06700
gene id: 1434123:MSVAZ_RS06700
uniprot id: A0A0E3Q4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434123:MSVAZ RS07685
gene id: 1434123:MSVAZ_RS07685
uniprot id: A0A0E3Q5M1
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS08935
gene id: 1434123:MSVAZ_RS08935
uniprot id: A0A0E3Q5I7
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12205
gene id: 1434123:MSVAZ_RS12205
uniprot id: A0A0E3Q7I2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

1434123:MSVAZ RS06245
gene id: 1434123:MSVAZ_RS06245
uniprot id: A0A0E3LH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS11135
gene id: 1434123:MSVAZ_RS11135
uniprot id: A0A0E3Q6H6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1434123:MSVAZ RS14510
gene id: 1434123:MSVAZ_RS14510
uniprot id: A0A0E3Q806
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1434123:MSVAZ RS16480
gene id: 1434123:MSVAZ_RS16480
uniprot id: A0A0E3Q6X3
names: Similarity
messages: Belongs to the FrhG family.

1434123:MSVAZ RS14445
gene id: 1434123:MSVAZ_RS14445
uniprot id: A0A0E3Q8H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

1434123:MSVAZ RS17620
gene id: 1434123:MSVAZ_RS17620
uniprot id: A0A0E3Q9I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1434123:MSVAZ RS08435
gene id: 1434123:MSVAZ_RS08435
uniprot id: A0A0E3LH91
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

1434123:MSVAZ RS12625
gene id: 1434123:MSVAZ_RS12625
uniprot id: A0A0E3Q701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS13805
gene id: 1434123:MSVAZ_RS13805
uniprot id: A0A0E3Q7P8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1434123:MSVAZ RS10215
gene id: 1434123:MSVAZ_RS10215
uniprot id: A0A0E3Q675
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1434123:MSVAZ RS11390
gene id: 1434123:MSVAZ_RS11390
uniprot id: A0A0E3Q6L2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05595
gene id: 1434123:MSVAZ_RS05595
uniprot id: A0A0E3Q487
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS14620
gene id: 1434123:MSVAZ_RS14620
uniprot id: A0A0E3Q7Z4
names: Similarity
messages: Belongs to the HsdR family.

1434123:MSVAZ RS05865
gene id: 1434123:MSVAZ_RS05865
uniprot id: A0A0E3Q3Y5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS05065
gene id: 1434123:MSVAZ_RS05065
uniprot id: A0A0E3Q4G9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434123:MSVAZ RS13920
gene id: 1434123:MSVAZ_RS13920
uniprot id: A0A0E3Q5W5
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1434123:MSVAZ RS02980
gene id: 1434123:MSVAZ_RS02980
uniprot id: A0A0E3Q0Z6
names: Similarity
messages: Belongs to the Ahb/Nir family.

1434123:MSVAZ RS17035
gene id: 1434123:MSVAZ_RS17035
uniprot id: A0A0E3Q796
names: Similarity
messages: Belongs to the HdrB family.

1434123:MSVAZ RS07515
gene id: 1434123:MSVAZ_RS07515
uniprot id: A0A0E3Q547
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1434123:MSVAZ RS15465
gene id: 1434123:MSVAZ_RS15465
uniprot id: A0A0E3Q6G5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1434123:MSVAZ RS11065
gene id: 1434123:MSVAZ_RS11065
uniprot id: A0A0E3Q728
names: Similarity
messages: Belongs to the UPF0210 family.

1434123:MSVAZ RS13995
gene id: 1434123:MSVAZ_RS13995
uniprot id: A0A0E3Q7T0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434123:MSVAZ RS12615
gene id: 1434123:MSVAZ_RS12615
uniprot id: A0A0E3Q7N6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS07625
gene id: 1434123:MSVAZ_RS07625
uniprot id: A0A0E3Q513
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1434123:MSVAZ RS08900
gene id: 1434123:MSVAZ_RS08900
uniprot id: A0A0E3Q5I2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS08065
gene id: 1434123:MSVAZ_RS08065
uniprot id: A0A0E3Q575
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS13295
gene id: 1434123:MSVAZ_RS13295
uniprot id: A0A0E3Q7F7
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS07140
gene id: 1434123:MSVAZ_RS07140
uniprot id: A0A0E3LH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434123:MSVAZ RS08790
gene id: 1434123:MSVAZ_RS08790
uniprot id: A0A0E3Q607
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

1434123:MSVAZ RS03955
gene id: 1434123:MSVAZ_RS03955
uniprot id: A0A0E3Q3K9
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

1434123:MSVAZ RS03495
gene id: 1434123:MSVAZ_RS03495
uniprot id: A0A0E3LGQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1434123:MSVAZ RS18725
gene id: 1434123:MSVAZ_RS18725
uniprot id: A0A0E3Q1Z6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434123:MSVAZ RS08665
gene id: 1434123:MSVAZ_RS08665
uniprot id: A0A0E3Q5Z1
names: Similarity
messages: Belongs to the acylphosphatase family.

1434123:MSVAZ RS16815
gene id: 1434123:MSVAZ_RS16815
uniprot id: A0A0E3Q950
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS00665
gene id: 1434123:MSVAZ_RS00665
uniprot id: A0A0E3Q298
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1434123:MSVAZ RS21445
gene id: 1434123:MSVAZ_RS21445
uniprot id: A0A0E3Q714
names: Similarity
messages: Belongs to the peptidase S8 family.

1434123:MSVAZ RS16535
gene id: 1434123:MSVAZ_RS16535
uniprot id: A0A0E3Q6Y4
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS01515
gene id: 1434123:MSVAZ_RS01515
uniprot id: A0A0E3Q2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS16885
gene id: 1434123:MSVAZ_RS16885
uniprot id: A0A0E3Q957
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1434123:MSVAZ RS16080
gene id: 1434123:MSVAZ_RS16080
uniprot id: A0A0E3Q951
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS15775
gene id: 1434123:MSVAZ_RS15775
uniprot id: A0A0E3LI17
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434123:MSVAZ RS03490
gene id: 1434123:MSVAZ_RS03490
uniprot id: A0A0E3Q2W0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1434123:MSVAZ RS10725
gene id: 1434123:MSVAZ_RS10725
uniprot id: A0A0E3Q6C2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434123:MSVAZ RS01510
gene id: 1434123:MSVAZ_RS01510
uniprot id: A0A0E3Q2X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS04885
gene id: 1434123:MSVAZ_RS04885
uniprot id: A0A0E3Q3Y2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1434123:MSVAZ RS01740
gene id: 1434123:MSVAZ_RS01740
uniprot id: A0A0E3LGI8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS10255
gene id: 1434123:MSVAZ_RS10255
uniprot id: A0A0E3LHG0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1434123:MSVAZ RS13065
gene id: 1434123:MSVAZ_RS13065
uniprot id: A0A0E3Q758
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1434123:MSVAZ RS09790
gene id: 1434123:MSVAZ_RS09790
uniprot id: A0A0E3Q402
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434123:MSVAZ RS01000
gene id: 1434123:MSVAZ_RS01000
uniprot id: A0A0E3Q1V1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434123:MSVAZ RS14575
gene id: 1434123:MSVAZ_RS14575
uniprot id: A0A0E3LHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1434123:MSVAZ RS00430
gene id: 1434123:MSVAZ_RS00430
uniprot id: A0A0E3Q1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1434123:MSVAZ RS02645
gene id: 1434123:MSVAZ_RS02645
uniprot id: A0A0E3Q3D6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS03055
gene id: 1434123:MSVAZ_RS03055
uniprot id: A0A0E3Q3J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1434123:MSVAZ RS11060
gene id: 1434123:MSVAZ_RS11060
uniprot id: A0A0E3Q6K6
names: Similarity
messages: Belongs to the UPF0237 family.

1434123:MSVAZ RS14115
gene id: 1434123:MSVAZ_RS14115
uniprot id: A0A0E3Q7U7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1434123:MSVAZ RS10870
gene id: 1434123:MSVAZ_RS10870
uniprot id: A0A0E3Q6Z9
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09565
gene id: 1434123:MSVAZ_RS09565
uniprot id: A0A0E3Q5L3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS10265
gene id: 1434123:MSVAZ_RS10265
uniprot id: A0A0E3Q4A1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1434123:MSVAZ RS10050
gene id: 1434123:MSVAZ_RS10050
uniprot id: A0A0E3Q623
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS10750
gene id: 1434123:MSVAZ_RS10750
uniprot id: A0A0E3Q6G1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1434123:MSVAZ RS17515
gene id: 1434123:MSVAZ_RS17515
uniprot id: A0A0E3Q9H5
names: Similarity
messages: Belongs to the FwdC/FmdC family.

1434123:MSVAZ RS02965
gene id: 1434123:MSVAZ_RS02965
uniprot id: A0A0E3Q307
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1434123:MSVAZ RS10230
gene id: 1434123:MSVAZ_RS10230
uniprot id: A0A0E3Q605
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1434123:MSVAZ RS08710
gene id: 1434123:MSVAZ_RS08710
uniprot id: A0A0E3Q3I4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

1434123:MSVAZ RS04785
gene id: 1434123:MSVAZ_RS04785
uniprot id: A0A0E3Q4D5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS03975
gene id: 1434123:MSVAZ_RS03975
uniprot id: A0A0E3Q355
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS04630
gene id: 1434123:MSVAZ_RS04630
uniprot id: A0A0E3Q4B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS09995
gene id: 1434123:MSVAZ_RS09995
uniprot id: A0A0E3Q428
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS09435
gene id: 1434123:MSVAZ_RS09435
uniprot id: A0A0E3Q5Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1434123:MSVAZ RS18595
gene id: 1434123:MSVAZ_RS18595
uniprot id: A0A0E3LIC4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1434123:MSVAZ RS03455
gene id: 1434123:MSVAZ_RS03455
uniprot id: A0A0E3Q166
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1434123:MSVAZ RS04970
gene id: 1434123:MSVAZ_RS04970
uniprot id: A0A0E3LGW0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS16195
gene id: 1434123:MSVAZ_RS16195
uniprot id: A0A0E3Q6S3
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS13385
gene id: 1434123:MSVAZ_RS13385
uniprot id: A0A0E3Q5K4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1434123:MSVAZ RS16775
gene id: 1434123:MSVAZ_RS16775
uniprot id: A0A0E3LI56
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS13610
gene id: 1434123:MSVAZ_RS13610
uniprot id: A0A0E3Q7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS17890
gene id: 1434123:MSVAZ_RS17890
uniprot id: A0A0E3Q9M3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434123:MSVAZ RS04675
gene id: 1434123:MSVAZ_RS04675
uniprot id: A0A0E3LGU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1434123:MSVAZ RS12925
gene id: 1434123:MSVAZ_RS12925
uniprot id: A0A0E3Q742
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434123:MSVAZ RS05210
gene id: 1434123:MSVAZ_RS05210
uniprot id: A0A0E3LGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1434123:MSVAZ RS05590
gene id: 1434123:MSVAZ_RS05590
uniprot id: A0A0E3Q229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS16890
gene id: 1434123:MSVAZ_RS16890
uniprot id: A0A0E3LI60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1434123:MSVAZ RS10275
gene id: 1434123:MSVAZ_RS10275
uniprot id: A0A0E3Q6Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1434123:MSVAZ RS03930
gene id: 1434123:MSVAZ_RS03930
uniprot id: A0A0E3Q409
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS13590
gene id: 1434123:MSVAZ_RS13590
uniprot id: A0A0E3Q5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS02185
gene id: 1434123:MSVAZ_RS02185
uniprot id: A0A0E3Q0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS06650
gene id: 1434123:MSVAZ_RS06650
uniprot id: A0A0E3Q541
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434123:MSVAZ RS11230
gene id: 1434123:MSVAZ_RS11230
uniprot id: A0A0E3Q748
names: Similarity
messages: Belongs to the TrpC family.

1434123:MSVAZ RS01320
gene id: 1434123:MSVAZ_RS01320
uniprot id: A0A0E3LGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS16580
gene id: 1434123:MSVAZ_RS16580
uniprot id: A0A0E3Q9C9
names: Similarity
messages: Belongs to the UPF0235 family.

1434123:MSVAZ RS04485
gene id: 1434123:MSVAZ_RS04485
uniprot id: A0A0E3LGU2
names: Function
names: Subcellular Location Annotation
messages: Cell wall formation.
messages: Cytoplasm

1434123:MSVAZ RS08565
gene id: 1434123:MSVAZ_RS08565
uniprot id: A0A0E3LH96
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1434123:MSVAZ RS17400
gene id: 1434123:MSVAZ_RS17400
uniprot id: A0A0E3LI80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434123:MSVAZ RS02405
gene id: 1434123:MSVAZ_RS02405
uniprot id: A0A0E3Q2E9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS11580
gene id: 1434123:MSVAZ_RS11580
uniprot id: A0A0E3Q797
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1434123:MSVAZ RS18475
gene id: 1434123:MSVAZ_RS18475
uniprot id: A0A0E3QA84
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434123:MSVAZ RS18010
gene id: 1434123:MSVAZ_RS18010
uniprot id: A0A0E3LIA3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1434123:MSVAZ RS16875
gene id: 1434123:MSVAZ_RS16875
uniprot id: A0A0E3Q976
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434123:MSVAZ RS06405
gene id: 1434123:MSVAZ_RS06405
uniprot id: A0A0E3LH15
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434123:MSVAZ RS11730
gene id: 1434123:MSVAZ_RS11730
uniprot id: A0A0E3LHL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS18225
gene id: 1434123:MSVAZ_RS18225
uniprot id: A0A0E3QA50
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS07355
gene id: 1434123:MSVAZ_RS07355
uniprot id: A0A0E3Q5H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1434123:MSVAZ RS04730
gene id: 1434123:MSVAZ_RS04730
uniprot id: A0A0E3Q3T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1434123:MSVAZ RS09520
gene id: 1434123:MSVAZ_RS09520
uniprot id: A0A0E3LHD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434123:MSVAZ RS11035
gene id: 1434123:MSVAZ_RS11035
uniprot id: A0A0E3Q724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1434123:MSVAZ RS05135
gene id: 1434123:MSVAZ_RS05135
uniprot id: A0A0E3LGW6
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS04070
gene id: 1434123:MSVAZ_RS04070
uniprot id: A0A0E3Q369
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1434123:MSVAZ RS04625
gene id: 1434123:MSVAZ_RS04625
uniprot id: A0A0E3LGU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1434123:MSVAZ RS09040
gene id: 1434123:MSVAZ_RS09040
uniprot id: A0A0E3Q5K0
names: Similarity
messages: Belongs to the class-I fumarase family.

1434123:MSVAZ RS08185
gene id: 1434123:MSVAZ_RS08185
uniprot id: A0A0E3LH82
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1434123:MSVAZ RS02590
gene id: 1434123:MSVAZ_RS02590
uniprot id: A0A0E3LGM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

1434123:MSVAZ RS06000
gene id: 1434123:MSVAZ_RS06000
uniprot id: A0A0E3LGZ9
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS13375
gene id: 1434123:MSVAZ_RS13375
uniprot id: A0A0E3Q7D2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS16950
gene id: 1434123:MSVAZ_RS16950
uniprot id: A0A0E3Q966
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434123:MSVAZ RS17965
gene id: 1434123:MSVAZ_RS17965
uniprot id: A0A0E3Q9K5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1434123:MSVAZ RS11790
gene id: 1434123:MSVAZ_RS11790
uniprot id: A0A0E3Q6R7
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS08735
gene id: 1434123:MSVAZ_RS08735
uniprot id: A0A0E3Q578
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1434123:MSVAZ RS18005
gene id: 1434123:MSVAZ_RS18005
uniprot id: A0A0E3Q7N0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1434123:MSVAZ RS06460
gene id: 1434123:MSVAZ_RS06460
uniprot id: A0A0E3LH17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS10450
gene id: 1434123:MSVAZ_RS10450
uniprot id: A0A0E3Q6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434123:MSVAZ RS14680
gene id: 1434123:MSVAZ_RS14680
uniprot id: A0A0E3Q8K7
names: Similarity
messages: Belongs to the MCM family.

1434123:MSVAZ RS06230
gene id: 1434123:MSVAZ_RS06230
uniprot id: A0A0E3Q4Y2
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1434123:MSVAZ RS10375
gene id: 1434123:MSVAZ_RS10375
uniprot id: A0A0E3LHG5
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

1434123:MSVAZ RS12050
gene id: 1434123:MSVAZ_RS12050
uniprot id: A0A0E3Q4Z7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434123:MSVAZ RS10710
gene id: 1434123:MSVAZ_RS10710
uniprot id: A0A0E3LHH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1434123:MSVAZ RS07155
gene id: 1434123:MSVAZ_RS07155
uniprot id: A0A0E3Q4U2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1434123:MSVAZ RS12095
gene id: 1434123:MSVAZ_RS12095
uniprot id: A0A0E3Q6Z7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS12730
gene id: 1434123:MSVAZ_RS12730
uniprot id: A0A0E3Q717
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS16845
gene id: 1434123:MSVAZ_RS16845
uniprot id: A0A0E3Q9J9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1434123:MSVAZ RS12545
gene id: 1434123:MSVAZ_RS12545
uniprot id: A0A0E3Q757
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09760
gene id: 1434123:MSVAZ_RS09760
uniprot id: A0A0E3Q6E3
names: Similarity
messages: Belongs to the CutA family.

1434123:MSVAZ RS01600
gene id: 1434123:MSVAZ_RS01600
uniprot id: A0A0E3LGI3
names: Similarity
messages: Belongs to the LarC family.

1434123:MSVAZ RS05795
gene id: 1434123:MSVAZ_RS05795
uniprot id: A0A0E3Q271
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1434123:MSVAZ RS12830
gene id: 1434123:MSVAZ_RS12830
uniprot id: A0A0E3Q5B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1434123:MSVAZ RS14240
gene id: 1434123:MSVAZ_RS14240
uniprot id: A0A0E3Q7W8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09685
gene id: 1434123:MSVAZ_RS09685
uniprot id: A0A0E3Q5X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1434123:MSVAZ RS05075
gene id: 1434123:MSVAZ_RS05075
uniprot id: A0A0E3Q3L5
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS01455
gene id: 1434123:MSVAZ_RS01455
uniprot id: A0A0E3Q2W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434123:MSVAZ RS16495
gene id: 1434123:MSVAZ_RS16495
uniprot id: A0A0E3Q8X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS03590
gene id: 1434123:MSVAZ_RS03590
uniprot id: A0A0E3LGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1434123:MSVAZ RS16240
gene id: 1434123:MSVAZ_RS16240
uniprot id: A0A0E3Q973
names: Similarity
messages: Belongs to the gas vesicle GvpA family.

1434123:MSVAZ RS14380
gene id: 1434123:MSVAZ_RS14380
uniprot id: A0A0E3LHW5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS04590
gene id: 1434123:MSVAZ_RS04590
uniprot id: A0A0E3Q4A8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS12085
gene id: 1434123:MSVAZ_RS12085
uniprot id: A0A0E3LHM9
names: Similarity
messages: Belongs to the GARS family.

1434123:MSVAZ RS17685
gene id: 1434123:MSVAZ_RS17685
uniprot id: A0A0E3Q7I1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1434123:MSVAZ RS02415
gene id: 1434123:MSVAZ_RS02415
uniprot id: A0A0E3Q0R1
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1434123:MSVAZ RS10130
gene id: 1434123:MSVAZ_RS10130
uniprot id: A0A0E3Q6J8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS02755
gene id: 1434123:MSVAZ_RS02755
uniprot id: A0A0E3Q0W5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1434123:MSVAZ RS02650
gene id: 1434123:MSVAZ_RS02650
uniprot id: A0A0E3Q2W3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS18210
gene id: 1434123:MSVAZ_RS18210
uniprot id: A0A0E3Q958
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434123:MSVAZ RS16510
gene id: 1434123:MSVAZ_RS16510
uniprot id: A0A0E3Q8Z9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1434123:MSVAZ RS03925
gene id: 1434123:MSVAZ_RS03925
uniprot id: A0A0E3Q3K3
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1434123:MSVAZ RS15160
gene id: 1434123:MSVAZ_RS15160
uniprot id: A0A0E3LHZ4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS01835
gene id: 1434123:MSVAZ_RS01835
uniprot id: A0A0E3Q0H8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS16520
gene id: 1434123:MSVAZ_RS16520
uniprot id: A0A0E3LI46
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1434123:MSVAZ RS04695
gene id: 1434123:MSVAZ_RS04695
uniprot id: A0A0E3Q3S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS15235
gene id: 1434123:MSVAZ_RS15235
uniprot id: A0A0E3Q6D0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS11325
gene id: 1434123:MSVAZ_RS11325
uniprot id: A0A0E3LHK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS09560
gene id: 1434123:MSVAZ_RS09560
uniprot id: A0A0E3Q5S4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1434123:MSVAZ RS12345
gene id: 1434123:MSVAZ_RS12345
uniprot id: A0A0E3Q6V8
names: Similarity
messages: Belongs to the ZPR1 family.

1434123:MSVAZ RS06480
gene id: 1434123:MSVAZ_RS06480
uniprot id: A0A0E3Q2H8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS07810
gene id: 1434123:MSVAZ_RS07810
uniprot id: A0A0E3LH68
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434123:MSVAZ RS05020
gene id: 1434123:MSVAZ_RS05020
uniprot id: A0A0E3Q1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS11495
gene id: 1434123:MSVAZ_RS11495
uniprot id: A0A0E3Q6K0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1434123:MSVAZ RS04035
gene id: 1434123:MSVAZ_RS04035
uniprot id: A0A0E3Q364
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS02805
gene id: 1434123:MSVAZ_RS02805
uniprot id: A0A0E3Q2K7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1434123:MSVAZ RS15445
gene id: 1434123:MSVAZ_RS15445
uniprot id: A0A0E3Q8W0
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434123:MSVAZ RS01125
gene id: 1434123:MSVAZ_RS01125
uniprot id: A0A0E3Q2A4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS06260
gene id: 1434123:MSVAZ_RS06260
uniprot id: A0A0E3Q4Y7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS03535
gene id: 1434123:MSVAZ_RS03535
uniprot id: A0A0E3Q3S2
names: Similarity
messages: Belongs to the NAD synthetase family.

1434123:MSVAZ RS10060
gene id: 1434123:MSVAZ_RS10060
uniprot id: A0A0E3Q6I8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS01815
gene id: 1434123:MSVAZ_RS01815
uniprot id: A0A0E3LGJ1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS14500
gene id: 1434123:MSVAZ_RS14500
uniprot id: A0A0E3LHW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS14490
gene id: 1434123:MSVAZ_RS14490
uniprot id: A0A0E3Q7X5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1434123:MSVAZ RS12335
gene id: 1434123:MSVAZ_RS12335
uniprot id: A0A0E3Q7J5
names: Similarity
messages: Belongs to the UPF0284 family.

1434123:MSVAZ RS18145
gene id: 1434123:MSVAZ_RS18145
uniprot id: A0A0E3Q9Q4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434123:MSVAZ RS15845
gene id: 1434123:MSVAZ_RS15845
uniprot id: A0A0E3Q923
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS01270
gene id: 1434123:MSVAZ_RS01270
uniprot id: A0A0E3Q2C0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS05005
gene id: 1434123:MSVAZ_RS05005
uniprot id: A0A0E3Q3W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1434123:MSVAZ RS03140
gene id: 1434123:MSVAZ_RS03140
uniprot id: A0A0E3Q3K7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1434123:MSVAZ RS15420
gene id: 1434123:MSVAZ_RS15420
uniprot id: A0A0E3Q8F7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1434123:MSVAZ RS01660
gene id: 1434123:MSVAZ_RS01660
uniprot id: A0A0E3Q0F8
names: Similarity
messages: Belongs to the citrate synthase family.

1434123:MSVAZ RS13340
gene id: 1434123:MSVAZ_RS13340
uniprot id: A0A0E3Q7C8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS08850
gene id: 1434123:MSVAZ_RS08850
uniprot id: A0A0E3Q5M8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS08395
gene id: 1434123:MSVAZ_RS08395
uniprot id: A0A0E3Q5G4
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1434123:MSVAZ RS07135
gene id: 1434123:MSVAZ_RS07135
uniprot id: A0A0E3Q2W8
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1434123:MSVAZ RS13850
gene id: 1434123:MSVAZ_RS13850
uniprot id: A0A0E3LHU5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS17195
gene id: 1434123:MSVAZ_RS17195
uniprot id: A0A0E3Q9Q5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434123:MSVAZ RS05235
gene id: 1434123:MSVAZ_RS05235
uniprot id: A0A0E3LGX0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1434123:MSVAZ RS03585
gene id: 1434123:MSVAZ_RS03585
uniprot id: A0A0E3Q1B7
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1434123:MSVAZ RS03625
gene id: 1434123:MSVAZ_RS03625
uniprot id: A0A0E3Q3G1
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

1434123:MSVAZ RS10755
gene id: 1434123:MSVAZ_RS10755
uniprot id: A0A0E3Q6Y2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1434123:MSVAZ RS02820
gene id: 1434123:MSVAZ_RS02820
uniprot id: A0A0E3Q315
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1434123:MSVAZ RS05360
gene id: 1434123:MSVAZ_RS05360
uniprot id: A0A0E3Q3R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1434123:MSVAZ RS06145
gene id: 1434123:MSVAZ_RS06145
uniprot id: A0A0E3Q429
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1434123:MSVAZ RS13080
gene id: 1434123:MSVAZ_RS13080
uniprot id: A0A0E3Q7D0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1434123:MSVAZ RS04725
gene id: 1434123:MSVAZ_RS04725
uniprot id: A0A0E3LGV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1434123:MSVAZ RS05265
gene id: 1434123:MSVAZ_RS05265
uniprot id: A0A0E3Q400
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434123:MSVAZ RS04040
gene id: 1434123:MSVAZ_RS04040
uniprot id: A0A0E3LGS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05995
gene id: 1434123:MSVAZ_RS05995
uniprot id: A0A0E3Q401
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1434123:MSVAZ RS01860
gene id: 1434123:MSVAZ_RS01860
uniprot id: A0A0E3Q2K6
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12700
gene id: 1434123:MSVAZ_RS12700
uniprot id: A0A0E3Q711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1434123:MSVAZ RS16275
gene id: 1434123:MSVAZ_RS16275
uniprot id: A0A0E3Q8U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

1434123:MSVAZ RS01130
gene id: 1434123:MSVAZ_RS01130
uniprot id: A0A0E3LGG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS04705
gene id: 1434123:MSVAZ_RS04705
uniprot id: A0A0E3Q3G4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1434123:MSVAZ RS13070
gene id: 1434123:MSVAZ_RS13070
uniprot id: A0A0E3Q5E8
names: Similarity
messages: Belongs to the UPF0228 family.

1434123:MSVAZ RS05975
gene id: 1434123:MSVAZ_RS05975
uniprot id: A0A0E3LGZ8
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudC subfamily.

1434123:MSVAZ RS16895
gene id: 1434123:MSVAZ_RS16895
uniprot id: A0A0E3Q8N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1434123:MSVAZ RS00285
gene id: 1434123:MSVAZ_RS00285
uniprot id: A0A0E3Q2E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1434123:MSVAZ RS02490
gene id: 1434123:MSVAZ_RS02490
uniprot id: A0A0E3LGL7
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1434123:MSVAZ RS06280
gene id: 1434123:MSVAZ_RS06280
uniprot id: A0A0E3Q2E5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS07365
gene id: 1434123:MSVAZ_RS07365
uniprot id: A0A0E3Q4W8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1434123:MSVAZ RS02860
gene id: 1434123:MSVAZ_RS02860
uniprot id: A0A0E3Q3G3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1434123:MSVAZ RS15790
gene id: 1434123:MSVAZ_RS15790
uniprot id: A0A0E3Q873
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1434123:MSVAZ RS14075
gene id: 1434123:MSVAZ_RS14075
uniprot id: A0A0E3Q7S2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1434123:MSVAZ RS18070
gene id: 1434123:MSVAZ_RS18070
uniprot id: A0A0E3Q942
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434123:MSVAZ RS06775
gene id: 1434123:MSVAZ_RS06775
uniprot id: A0A0E3Q2M1
names: Similarity
messages: Belongs to the UPF0228 family.

1434123:MSVAZ RS15780
gene id: 1434123:MSVAZ_RS15780
uniprot id: A0A0E3Q913
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434123:MSVAZ RS15320
gene id: 1434123:MSVAZ_RS15320
uniprot id: A0A0E3Q8T8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1434123:MSVAZ RS13460
gene id: 1434123:MSVAZ_RS13460
uniprot id: A0A0E3Q842
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS12920
gene id: 1434123:MSVAZ_RS12920
uniprot id: A0A0E3LHR0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434123:MSVAZ RS04975
gene id: 1434123:MSVAZ_RS04975
uniprot id: A0A0E3Q3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS07615
gene id: 1434123:MSVAZ_RS07615
uniprot id: A0A0E3Q5L2
names: Function
messages: Part of a potassium transport system.

1434123:MSVAZ RS16420
gene id: 1434123:MSVAZ_RS16420
uniprot id: A0A0E3LI42
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1434123:MSVAZ RS16665
gene id: 1434123:MSVAZ_RS16665
uniprot id: A0A0E3Q925
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1434123:MSVAZ RS13765
gene id: 1434123:MSVAZ_RS13765
uniprot id: A0A0E3Q5U7
names: Similarity
messages: Belongs to the HypD family.

1434123:MSVAZ RS16945
gene id: 1434123:MSVAZ_RS16945
uniprot id: A0A0E3Q9L1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434123:MSVAZ RS18220
gene id: 1434123:MSVAZ_RS18220
uniprot id: A0A0E3Q9R3
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1434123:MSVAZ RS13335
gene id: 1434123:MSVAZ_RS13335
uniprot id: A0A0E3LHS6
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS07800
gene id: 1434123:MSVAZ_RS07800
uniprot id: A0A0E3Q4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1434123:MSVAZ RS17465
gene id: 1434123:MSVAZ_RS17465
uniprot id: A0A0E3Q9D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS10250
gene id: 1434123:MSVAZ_RS10250
uniprot id: A0A0E3Q657
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1434123:MSVAZ RS05750
gene id: 1434123:MSVAZ_RS05750
uniprot id: A0A0E3Q4B3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS18545
gene id: 1434123:MSVAZ_RS18545
uniprot id: A0A0E3Q9V1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS11505
gene id: 1434123:MSVAZ_RS11505
uniprot id: A0A0E3LHK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1434123:MSVAZ RS01605
gene id: 1434123:MSVAZ_RS01605
uniprot id: A0A0E3Q2L2
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1434123:MSVAZ RS00400
gene id: 1434123:MSVAZ_RS00400
uniprot id: A0A0E3LGD7
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS10660
gene id: 1434123:MSVAZ_RS10660
uniprot id: A0A0E3LHH6
names: Similarity
messages: Belongs to the ATPase gamma chain family.

1434123:MSVAZ RS02850
gene id: 1434123:MSVAZ_RS02850
uniprot id: A0A0E3Q0X4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS15770
gene id: 1434123:MSVAZ_RS15770
uniprot id: A0A0E3Q8N7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434123:MSVAZ RS09645
gene id: 1434123:MSVAZ_RS09645
uniprot id: A0A0E3Q6C1
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

1434123:MSVAZ RS13595
gene id: 1434123:MSVAZ_RS13595
uniprot id: A0A0E3Q7L9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1434123:MSVAZ RS01570
gene id: 1434123:MSVAZ_RS01570
uniprot id: A0A0E3LGI2
names: Subunit
messages: Homotetramer.

1434123:MSVAZ RS13425
gene id: 1434123:MSVAZ_RS13425
uniprot id: A0A0E3Q7H2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1434123:MSVAZ RS07080
gene id: 1434123:MSVAZ_RS07080
uniprot id: A0A0E3Q4Y4
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02340
gene id: 1434123:MSVAZ_RS02340
uniprot id: A0A0E3Q2E1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1434123:MSVAZ RS10555
gene id: 1434123:MSVAZ_RS10555
uniprot id: A0A0E3LHH2
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS15800
gene id: 1434123:MSVAZ_RS15800
uniprot id: A0A0E3LI18
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1434123:MSVAZ RS12950
gene id: 1434123:MSVAZ_RS12950
uniprot id: A0A0E3LHR1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS08440
gene id: 1434123:MSVAZ_RS08440
uniprot id: A0A0E3Q5B4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1434123:MSVAZ RS17855
gene id: 1434123:MSVAZ_RS17855
uniprot id: A0A0E3Q9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1434123:MSVAZ RS11820
gene id: 1434123:MSVAZ_RS11820
uniprot id: A0A0E3Q7D3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS14340
gene id: 1434123:MSVAZ_RS14340
uniprot id: A0A0E3Q8G6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS05685
gene id: 1434123:MSVAZ_RS05685
uniprot id: A0A0E3LGY8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS01325
gene id: 1434123:MSVAZ_RS01325
uniprot id: A0A0E3Q2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS14200
gene id: 1434123:MSVAZ_RS14200
uniprot id: A0A0E3Q5Z6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434123:MSVAZ RS08075
gene id: 1434123:MSVAZ_RS08075
uniprot id: A0A0E3Q390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1434123:MSVAZ RS15210
gene id: 1434123:MSVAZ_RS15210
uniprot id: A0A0E3Q8S5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS04870
gene id: 1434123:MSVAZ_RS04870
uniprot id: A0A0E3Q3U8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1434123:MSVAZ RS11210
gene id: 1434123:MSVAZ_RS11210
uniprot id: A0A0E3Q6F7
names: Similarity
messages: Belongs to the TrpF family.

1434123:MSVAZ RS09345
gene id: 1434123:MSVAZ_RS09345
uniprot id: A0A0E3Q5H4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS11845
gene id: 1434123:MSVAZ_RS11845
uniprot id: A0A0E3Q6W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1434123:MSVAZ RS06565
gene id: 1434123:MSVAZ_RS06565
uniprot id: A0A0E3Q2I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS13835
gene id: 1434123:MSVAZ_RS13835
uniprot id: A0A0E3Q7Q5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1434123:MSVAZ RS04690
gene id: 1434123:MSVAZ_RS04690
uniprot id: A0A0E3Q4C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1434123:MSVAZ RS14535
gene id: 1434123:MSVAZ_RS14535
uniprot id: A0A0E3Q640
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1434123:MSVAZ RS02930
gene id: 1434123:MSVAZ_RS02930
uniprot id: A0A0E3Q3H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1434123:MSVAZ RS12750
gene id: 1434123:MSVAZ_RS12750
uniprot id: A0A0E3Q7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS00335
gene id: 1434123:MSVAZ_RS00335
uniprot id: A0A0E3PZZ9
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS16680
gene id: 1434123:MSVAZ_RS16680
uniprot id: A0A0E3Q9E4
names: Similarity
messages: Belongs to the AAA ATPase family.

1434123:MSVAZ RS16905
gene id: 1434123:MSVAZ_RS16905
uniprot id: A0A0E3Q982
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1434123:MSVAZ RS13495
gene id: 1434123:MSVAZ_RS13495
uniprot id: A0A0E3Q863
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

1434123:MSVAZ RS03035
gene id: 1434123:MSVAZ_RS03035
uniprot id: A0A0E3Q2P2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434123:MSVAZ RS01295
gene id: 1434123:MSVAZ_RS01295
uniprot id: A0A0E3Q2T9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS08280
gene id: 1434123:MSVAZ_RS08280
uniprot id: A0A0E3Q3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS02495
gene id: 1434123:MSVAZ_RS02495
uniprot id: A0A0E3Q3C5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1434123:MSVAZ RS15510
gene id: 1434123:MSVAZ_RS15510
uniprot id: A0A0E3Q8X3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434123:MSVAZ RS18520
gene id: 1434123:MSVAZ_RS18520
uniprot id: A0A0E3LIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434123:MSVAZ RS11090
gene id: 1434123:MSVAZ_RS11090
uniprot id: A0A0E3Q6K9
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS06670
gene id: 1434123:MSVAZ_RS06670
uniprot id: A0A0E3Q2K4
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02985
gene id: 1434123:MSVAZ_RS02985
uniprot id: A0A0E3Q342
names: Similarity
messages: Belongs to the Ahb/Nir family.

1434123:MSVAZ RS02440
gene id: 1434123:MSVAZ_RS02440
uniprot id: A0A0E3Q2F3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1434123:MSVAZ RS04650
gene id: 1434123:MSVAZ_RS04650
uniprot id: A0A0E3LGU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS16940
gene id: 1434123:MSVAZ_RS16940
uniprot id: A0A0E3LI62
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

1434123:MSVAZ RS12080
gene id: 1434123:MSVAZ_RS12080
uniprot id: A0A0E3Q6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1434123:MSVAZ RS07620
gene id: 1434123:MSVAZ_RS07620
uniprot id: A0A0E3LH61
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1434123:MSVAZ RS11205
gene id: 1434123:MSVAZ_RS11205
uniprot id: A0A0E3Q6I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1434123:MSVAZ RS14325
gene id: 1434123:MSVAZ_RS14325
uniprot id: A0A0E3Q616
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1434123:MSVAZ RS13365
gene id: 1434123:MSVAZ_RS13365
uniprot id: A0A0E3LHS7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS04620
gene id: 1434123:MSVAZ_RS04620
uniprot id: A0A0E3Q3U7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434123:MSVAZ RS03725
gene id: 1434123:MSVAZ_RS03725
uniprot id: A0A0E3Q3H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS10665
gene id: 1434123:MSVAZ_RS10665
uniprot id: A0A0E3Q6B3
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

1434123:MSVAZ RS03950
gene id: 1434123:MSVAZ_RS03950
uniprot id: A0A0E3Q1G4
names: Subcellular Location Annotation
messages: Cytoplasm

1434123:MSVAZ RS13175
gene id: 1434123:MSVAZ_RS13175
uniprot id: A0A0E3Q7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS03040
gene id: 1434123:MSVAZ_RS03040
uniprot id: A0A0E3Q106
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1434123:MSVAZ RS09070
gene id: 1434123:MSVAZ_RS09070
uniprot id: A0A0E3Q5K6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS12300
gene id: 1434123:MSVAZ_RS12300
uniprot id: A0A0E3Q7J0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1434123:MSVAZ RS00910
gene id: 1434123:MSVAZ_RS00910
uniprot id: A0A0E3Q055
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1434123:MSVAZ RS16900
gene id: 1434123:MSVAZ_RS16900
uniprot id: A0A0E3Q776
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1434123:MSVAZ RS02065
gene id: 1434123:MSVAZ_RS02065
uniprot id: A0A0E3Q2S0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02950
gene id: 1434123:MSVAZ_RS02950
uniprot id: A0A0E3LGN3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS16515
gene id: 1434123:MSVAZ_RS16515
uniprot id: A0A0E3Q9B8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1434123:MSVAZ RS00500
gene id: 1434123:MSVAZ_RS00500
uniprot id: A0A0E3Q1M9
names: Similarity
messages: Belongs to the DtxR/MntR family.

1434123:MSVAZ RS03915
gene id: 1434123:MSVAZ_RS03915
uniprot id: A0A0E3LGR9
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Belongs to the KdsC family.
messages: Homotetramer.

1434123:MSVAZ RS21380
gene id: 1434123:MSVAZ_RS21380
uniprot id: A0A0E3Q821
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09600
gene id: 1434123:MSVAZ_RS09600
uniprot id: A0A0E3Q5L8
names: Similarity
messages: Belongs to the PspA/IM30 family.

1434123:MSVAZ RS18470
gene id: 1434123:MSVAZ_RS18470
uniprot id: A0A0E3Q9U2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434123:MSVAZ RS00310
gene id: 1434123:MSVAZ_RS00310
uniprot id: A0A0E3Q238
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1434123:MSVAZ RS05365
gene id: 1434123:MSVAZ_RS05365
uniprot id: A0A0E3Q1Z9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS03675
gene id: 1434123:MSVAZ_RS03675
uniprot id: A0A0E3Q3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434123:MSVAZ RS17880
gene id: 1434123:MSVAZ_RS17880
uniprot id: A0A0E3Q7K2
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12370
gene id: 1434123:MSVAZ_RS12370
uniprot id: A0A0E3Q6Z3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434123:MSVAZ RS10150
gene id: 1434123:MSVAZ_RS10150
uniprot id: A0A0E3Q448
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09290
gene id: 1434123:MSVAZ_RS09290
uniprot id: A0A0E3LHC3
names: Similarity
messages: Belongs to the UPF0228 family.

1434123:MSVAZ RS07505
gene id: 1434123:MSVAZ_RS07505
uniprot id: A0A0E3Q4Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1434123:MSVAZ RS16185
gene id: 1434123:MSVAZ_RS16185
uniprot id: A0A0E3Q8S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

1434123:MSVAZ RS18420
gene id: 1434123:MSVAZ_RS18420
uniprot id: A0A0E3Q9R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1434123:MSVAZ RS05670
gene id: 1434123:MSVAZ_RS05670
uniprot id: A0A0E3Q3V5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05340
gene id: 1434123:MSVAZ_RS05340
uniprot id: A0A0E3Q453
names: Similarity
messages: Belongs to the HsdR family.

1434123:MSVAZ RS17275
gene id: 1434123:MSVAZ_RS17275
uniprot id: A0A0E3Q9E1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1434123:MSVAZ RS04920
gene id: 1434123:MSVAZ_RS04920
uniprot id: A0A0E3Q3Y7
names: Similarity
messages: Belongs to the DEAD box helicase family.

1434123:MSVAZ RS17870
gene id: 1434123:MSVAZ_RS17870
uniprot id: A0A0E3Q9J0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

1434123:MSVAZ RS15240
gene id: 1434123:MSVAZ_RS15240
uniprot id: A0A0E3Q8G0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS07160
gene id: 1434123:MSVAZ_RS07160
uniprot id: A0A0E3Q4L1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1434123:MSVAZ RS00550
gene id: 1434123:MSVAZ_RS00550
uniprot id: A0A0E3Q2I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1434123:MSVAZ RS09535
gene id: 1434123:MSVAZ_RS09535
uniprot id: A0A0E3Q5K7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434123:MSVAZ RS04710
gene id: 1434123:MSVAZ_RS04710
uniprot id: A0A0E3Q1S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS11800
gene id: 1434123:MSVAZ_RS11800
uniprot id: A0A0E3LHL9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434123:MSVAZ RS04565
gene id: 1434123:MSVAZ_RS04565
uniprot id: A0A0E3Q3Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS05665
gene id: 1434123:MSVAZ_RS05665
uniprot id: A0A0E3Q460
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS00205
gene id: 1434123:MSVAZ_RS00205
uniprot id: A0A0E3Q1G8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434123:MSVAZ RS04900
gene id: 1434123:MSVAZ_RS04900
uniprot id: A0A0E3Q3V3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434123:MSVAZ RS07835
gene id: 1434123:MSVAZ_RS07835
uniprot id: A0A0E3Q4U0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1434123:MSVAZ RS17595
gene id: 1434123:MSVAZ_RS17595
uniprot id: A0A0E3Q9W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434123:MSVAZ RS13780
gene id: 1434123:MSVAZ_RS13780
uniprot id: A0A0E3Q8A3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434123:MSVAZ RS05355
gene id: 1434123:MSVAZ_RS05355
uniprot id: A0A0E3LGX5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1434123:MSVAZ RS02295
gene id: 1434123:MSVAZ_RS02295
uniprot id: A0A0E3Q397
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1434123:MSVAZ RS16365
gene id: 1434123:MSVAZ_RS16365
uniprot id: A0A0E3Q8V7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1434123:MSVAZ RS10875
gene id: 1434123:MSVAZ_RS10875
uniprot id: A0A0E3Q6E2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434123:MSVAZ RS03230
gene id: 1434123:MSVAZ_RS03230
uniprot id: A0A0E3LGP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1434123:MSVAZ RS00295
gene id: 1434123:MSVAZ_RS00295
uniprot id: A0A0E3Q1K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1434123:MSVAZ RS12720
gene id: 1434123:MSVAZ_RS12720
uniprot id: A0A0E3Q7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1434123:MSVAZ RS13745
gene id: 1434123:MSVAZ_RS13745
uniprot id: A0A0E3Q8A0
names: Similarity
messages: Belongs to the HypE family.

1434123:MSVAZ RS04640
gene id: 1434123:MSVAZ_RS04640
uniprot id: A0A0E3Q3F3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1434123:MSVAZ RS14795
gene id: 1434123:MSVAZ_RS14795
uniprot id: A0A0E3Q870
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434123:MSVAZ RS02330
gene id: 1434123:MSVAZ_RS02330
uniprot id: A0A0E3LGL1
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434123:MSVAZ RS01240
gene id: 1434123:MSVAZ_RS01240
uniprot id: A0A0E3Q1Y0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS06035
gene id: 1434123:MSVAZ_RS06035
uniprot id: A0A0E3Q2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1434123:MSVAZ RS16805
gene id: 1434123:MSVAZ_RS16805
uniprot id: A0A0E3LI57
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS04000
gene id: 1434123:MSVAZ_RS04000
uniprot id: A0A0E3Q3H0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS08865
gene id: 1434123:MSVAZ_RS08865
uniprot id: A0A0E3Q5H7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434123:MSVAZ RS18045
gene id: 1434123:MSVAZ_RS18045
uniprot id: A0A0E3Q9P3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS08870
gene id: 1434123:MSVAZ_RS08870
uniprot id: A0A0E3Q599
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434123:MSVAZ RS07085
gene id: 1434123:MSVAZ_RS07085
uniprot id: A0A0E3Q5D5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS18055
gene id: 1434123:MSVAZ_RS18055
uniprot id: A0A0E3Q9M0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434123:MSVAZ RS00590
gene id: 1434123:MSVAZ_RS00590
uniprot id: A0A0E3Q1P6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1434123:MSVAZ RS09255
gene id: 1434123:MSVAZ_RS09255
uniprot id: A0A0E3Q5S1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1434123:MSVAZ RS18270
gene id: 1434123:MSVAZ_RS18270
uniprot id: A0A0E3Q9P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434123:MSVAZ RS07205
gene id: 1434123:MSVAZ_RS07205
uniprot id: A0A0E3Q5F5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS18015
gene id: 1434123:MSVAZ_RS18015
uniprot id: A0A0E3Q9P0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1434123:MSVAZ RS12110
gene id: 1434123:MSVAZ_RS12110
uniprot id: A0A0E3LHN0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS05800
gene id: 1434123:MSVAZ_RS05800
uniprot id: A0A0E3LGZ3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS12165
gene id: 1434123:MSVAZ_RS12165
uniprot id: A0A0E3LHN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1434123:MSVAZ RS02135
gene id: 1434123:MSVAZ_RS02135
uniprot id: A0A0E3Q2T2
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

1434123:MSVAZ RS18495
gene id: 1434123:MSVAZ_RS18495
uniprot id: A0A0E3Q998
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

1434123:MSVAZ RS13910
gene id: 1434123:MSVAZ_RS13910
uniprot id: A0A0E3Q7P3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS00675
gene id: 1434123:MSVAZ_RS00675
uniprot id: A0A0E3Q2K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1434123:MSVAZ RS02575
gene id: 1434123:MSVAZ_RS02575
uniprot id: A0A0E3Q2Y1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS02830
gene id: 1434123:MSVAZ_RS02830
uniprot id: A0A0E3Q2Y7
names: Similarity
messages: Belongs to the MEMO1 family.

1434123:MSVAZ RS21605
gene id: 1434123:MSVAZ_RS21605
uniprot id: A0A0E3Q8Q6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1434123:MSVAZ RS18090
gene id: 1434123:MSVAZ_RS18090
uniprot id: A0A0E3LIA6
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434123:MSVAZ RS00290
gene id: 1434123:MSVAZ_RS00290
uniprot id: A0A0E3Q206
names: Subcellular Location Annotation
messages: Cytoplasm

1434123:MSVAZ RS16560
gene id: 1434123:MSVAZ_RS16560
uniprot id: A0A0E3Q8G3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS10220
gene id: 1434123:MSVAZ_RS10220
uniprot id: A0A0E3Q6P4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS04600
gene id: 1434123:MSVAZ_RS04600
uniprot id: A0A0E3LGU6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1434123:MSVAZ RS00215
gene id: 1434123:MSVAZ_RS00215
uniprot id: A0A0E3Q1Z5
names: Similarity
messages: Belongs to the UPF0201 family.

1434123:MSVAZ RS11525
gene id: 1434123:MSVAZ_RS11525
uniprot id: A0A0E3Q6K5
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1434123:MSVAZ RS07325
gene id: 1434123:MSVAZ_RS07325
uniprot id: A0A0E3Q5H1
names: Similarity
messages: Belongs to the peptidase C56 family.

1434123:MSVAZ RS10680
gene id: 1434123:MSVAZ_RS10680
uniprot id: A0A0E3Q6F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1434123:MSVAZ RS07405
gene id: 1434123:MSVAZ_RS07405
uniprot id: A0A0E3Q300
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1434123:MSVAZ RS00445
gene id: 1434123:MSVAZ_RS00445
uniprot id: A0A0E3LGD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1434123:MSVAZ RS17815
gene id: 1434123:MSVAZ_RS17815
uniprot id: A0A0E3Q7J3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS00540
gene id: 1434123:MSVAZ_RS00540
uniprot id: A0A0E3Q272
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1434123:MSVAZ RS14125
gene id: 1434123:MSVAZ_RS14125
uniprot id: A0A0E3Q7S7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS01530
gene id: 1434123:MSVAZ_RS01530
uniprot id: A0A0E3Q0D8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS05790
gene id: 1434123:MSVAZ_RS05790
uniprot id: A0A0E3Q3X2
names: Similarity
messages: Belongs to the DMRL synthase family.

1434123:MSVAZ RS16160
gene id: 1434123:MSVAZ_RS16160
uniprot id: A0A0E3Q6R8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1434123:MSVAZ RS01545
gene id: 1434123:MSVAZ_RS01545
uniprot id: A0A0E3LGI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS15245
gene id: 1434123:MSVAZ_RS15245
uniprot id: A0A0E3LHZ7
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS18230
gene id: 1434123:MSVAZ_RS18230
uniprot id: A0A0E3LIB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS00975
gene id: 1434123:MSVAZ_RS00975
uniprot id: A0A0E3Q063
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS17540
gene id: 1434123:MSVAZ_RS17540
uniprot id: A0A0E3Q8X5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS11575
gene id: 1434123:MSVAZ_RS11575
uniprot id: A0A0E3Q6S4
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1434123:MSVAZ RS18265
gene id: 1434123:MSVAZ_RS18265
uniprot id: A0A0E3QA54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1434123:MSVAZ RS00175
gene id: 1434123:MSVAZ_RS00175
uniprot id: A0A0E3PZU7
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02825
gene id: 1434123:MSVAZ_RS02825
uniprot id: A0A0E3Q3F6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS14370
gene id: 1434123:MSVAZ_RS14370
uniprot id: A0A0E3Q8H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS00455
gene id: 1434123:MSVAZ_RS00455
uniprot id: A0A0E3Q2H0
names: Function
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1434123:MSVAZ RS06550
gene id: 1434123:MSVAZ_RS06550
uniprot id: A0A0E3Q4H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1434123:MSVAZ RS17140
gene id: 1434123:MSVAZ_RS17140
uniprot id: A0A0E3LI70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS00940
gene id: 1434123:MSVAZ_RS00940
uniprot id: A0A0E3Q058
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

1434123:MSVAZ RS02305
gene id: 1434123:MSVAZ_RS02305
uniprot id: A0A0E3LGL0
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1434123:MSVAZ RS08275
gene id: 1434123:MSVAZ_RS08275
uniprot id: A0A0E3Q504
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS11040
gene id: 1434123:MSVAZ_RS11040
uniprot id: A0A0E3Q6G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1434123:MSVAZ RS12735
gene id: 1434123:MSVAZ_RS12735
uniprot id: A0A0E3Q596
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS18370
gene id: 1434123:MSVAZ_RS18370
uniprot id: A0A0E3LIB6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1434123:MSVAZ RS05110
gene id: 1434123:MSVAZ_RS05110
uniprot id: A0A0E3Q3M0
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1434123:MSVAZ RS11465
gene id: 1434123:MSVAZ_RS11465
uniprot id: A0A0E3Q6M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1434123:MSVAZ RS04890
gene id: 1434123:MSVAZ_RS04890
uniprot id: A0A0E3LGV7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434123:MSVAZ RS04605
gene id: 1434123:MSVAZ_RS04605
uniprot id: A0A0E3Q3R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1434123:MSVAZ RS07510
gene id: 1434123:MSVAZ_RS07510
uniprot id: A0A0E3Q313
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1434123:MSVAZ RS09215
gene id: 1434123:MSVAZ_RS09215
uniprot id: A0A0E3Q5F2
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS00490
gene id: 1434123:MSVAZ_RS00490
uniprot id: A0A0E3Q225
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS03465
gene id: 1434123:MSVAZ_RS03465
uniprot id: A0A0E3Q3B6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1434123:MSVAZ RS07755
gene id: 1434123:MSVAZ_RS07755
uniprot id: A0A0E3Q5M9
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1434123:MSVAZ RS11380
gene id: 1434123:MSVAZ_RS11380
uniprot id: A0A0E3Q6P7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1434123:MSVAZ RS04610
gene id: 1434123:MSVAZ_RS04610
uniprot id: A0A0E3Q3E8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12025
gene id: 1434123:MSVAZ_RS12025
uniprot id: A0A0E3Q6Y7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1434123:MSVAZ RS08080
gene id: 1434123:MSVAZ_RS08080
uniprot id: A0A0E3LH78
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS09315
gene id: 1434123:MSVAZ_RS09315
uniprot id: A0A0E3LHC4
names: Similarity
messages: Belongs to the LOR family.

1434123:MSVAZ RS17900
gene id: 1434123:MSVAZ_RS17900
uniprot id: A0A0E3Q9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1434123:MSVAZ RS04735
gene id: 1434123:MSVAZ_RS04735
uniprot id: A0A0E3Q3G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS08295
gene id: 1434123:MSVAZ_RS08295
uniprot id: A0A0E3LH86
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1434123:MSVAZ RS16490
gene id: 1434123:MSVAZ_RS16490
uniprot id: A0A0E3Q9B0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434123:MSVAZ RS06120
gene id: 1434123:MSVAZ_RS06120
uniprot id: A0A0E3Q2C1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS01555
gene id: 1434123:MSVAZ_RS01555
uniprot id: A0A0E3Q215
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1434123:MSVAZ RS11620
gene id: 1434123:MSVAZ_RS11620
uniprot id: A0A0E3Q7A3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1434123:MSVAZ RS05700
gene id: 1434123:MSVAZ_RS05700
uniprot id: A0A0E3Q464
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS11475
gene id: 1434123:MSVAZ_RS11475
uniprot id: A0A0E3Q4S4
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1434123:MSVAZ RS15255
gene id: 1434123:MSVAZ_RS15255
uniprot id: A0A0E3Q8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05295
gene id: 1434123:MSVAZ_RS05295
uniprot id: A0A0E3Q407
names: Similarity
messages: Belongs to the UPF0285 family.

1434123:MSVAZ RS17970
gene id: 1434123:MSVAZ_RS17970
uniprot id: A0A0E3Q931
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS03470
gene id: 1434123:MSVAZ_RS03470
uniprot id: A0A0E3Q3R2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS01220
gene id: 1434123:MSVAZ_RS01220
uniprot id: A0A0E3LGG8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS17200
gene id: 1434123:MSVAZ_RS17200
uniprot id: A0A0E3Q9A4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1434123:MSVAZ RS14495
gene id: 1434123:MSVAZ_RS14495
uniprot id: A0A0E3Q7R5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1434123:MSVAZ RS04385
gene id: 1434123:MSVAZ_RS04385
uniprot id: A0A0E3Q3B0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS11150
gene id: 1434123:MSVAZ_RS11150
uniprot id: A0A0E3Q4M8
names: Similarity
messages: Belongs to the TlyA family.

1434123:MSVAZ RS06350
gene id: 1434123:MSVAZ_RS06350
uniprot id: A0A0E3LH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1434123:MSVAZ RS10170
gene id: 1434123:MSVAZ_RS10170
uniprot id: A0A0E3Q5Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434123:MSVAZ RS06600
gene id: 1434123:MSVAZ_RS06600
uniprot id: A0A0E3Q2J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434123:MSVAZ RS04665
gene id: 1434123:MSVAZ_RS04665
uniprot id: A0A0E3Q3S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS02500
gene id: 1434123:MSVAZ_RS02500
uniprot id: A0A0E3Q2U8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1434123:MSVAZ RS10145
gene id: 1434123:MSVAZ_RS10145
uniprot id: A0A0E3Q5V4
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12310
gene id: 1434123:MSVAZ_RS12310
uniprot id: A0A0E3Q6Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1434123:MSVAZ RS01655
gene id: 1434123:MSVAZ_RS01655
uniprot id: A0A0E3Q228
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1434123:MSVAZ RS11680
gene id: 1434123:MSVAZ_RS11680
uniprot id: A0A0E3LHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS03345
gene id: 1434123:MSVAZ_RS03345
uniprot id: A0A0E3Q371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1434123:MSVAZ RS17160
gene id: 1434123:MSVAZ_RS17160
uniprot id: A0A0E3Q9Q0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS15590
gene id: 1434123:MSVAZ_RS15590
uniprot id: A0A0E3Q855
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS13555
gene id: 1434123:MSVAZ_RS13555
uniprot id: A0A0E3Q5R6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS15195
gene id: 1434123:MSVAZ_RS15195
uniprot id: A0A0E3Q816
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1434123:MSVAZ RS08630
gene id: 1434123:MSVAZ_RS08630
uniprot id: A0A0E3Q5J7
names: Similarity
messages: Belongs to the UPF0677 family.

1434123:MSVAZ RS11875
gene id: 1434123:MSVAZ_RS11875
uniprot id: A0A0E3Q4X7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434123:MSVAZ RS05320
gene id: 1434123:MSVAZ_RS05320
uniprot id: A0A0E3Q4K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434123:MSVAZ RS07990
gene id: 1434123:MSVAZ_RS07990
uniprot id: A0A0E3Q5A9
names: Function
messages: Part of a potassium transport system.

1434123:MSVAZ RS09570
gene id: 1434123:MSVAZ_RS09570
uniprot id: A0A0E3LHD4
names: Function
messages: Part of a potassium transport system.

1434123:MSVAZ RS08780
gene id: 1434123:MSVAZ_RS08780
uniprot id: A0A0E3Q3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1434123:MSVAZ RS09445
gene id: 1434123:MSVAZ_RS09445
uniprot id: A0A0E3LHC9
names: Subcellular Location Annotation
messages: Cytoplasm

1434123:MSVAZ RS17600
gene id: 1434123:MSVAZ_RS17600
uniprot id: A0A0E3Q9F7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS10770
gene id: 1434123:MSVAZ_RS10770
uniprot id: A0A0E3LHI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434123:MSVAZ RS07410
gene id: 1434123:MSVAZ_RS07410
uniprot id: A0A0E3LH53
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1434123:MSVAZ RS17850
gene id: 1434123:MSVAZ_RS17850
uniprot id: A0A0E3Q7J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1434123:MSVAZ RS18350
gene id: 1434123:MSVAZ_RS18350
uniprot id: A0A0E3Q978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434123:MSVAZ RS11300
gene id: 1434123:MSVAZ_RS11300
uniprot id: A0A0E3LHK0
names: Similarity
messages: Belongs to the AOR/FOR family.

1434123:MSVAZ RS03890
gene id: 1434123:MSVAZ_RS03890
uniprot id: A0A0E3LGR8
names: Similarity
messages: Belongs to the MtrH family.

1434123:MSVAZ RS13210
gene id: 1434123:MSVAZ_RS13210
uniprot id: A0A0E3Q7Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434123:MSVAZ RS06605
gene id: 1434123:MSVAZ_RS06605
uniprot id: A0A0E3Q4N1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1434123:MSVAZ RS06740
gene id: 1434123:MSVAZ_RS06740
uniprot id: A0A0E3Q2L5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS17680
gene id: 1434123:MSVAZ_RS17680
uniprot id: A0A0E3Q8Z4
names: Similarity
messages: Belongs to the peptidase M24B family.

1434123:MSVAZ RS08465
gene id: 1434123:MSVAZ_RS08465
uniprot id: A0A0E3Q5W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1434123:MSVAZ RS04005
gene id: 1434123:MSVAZ_RS04005
uniprot id: A0A0E3Q359
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS15085
gene id: 1434123:MSVAZ_RS15085
uniprot id: A0A0E3LHZ1
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

1434123:MSVAZ RS18205
gene id: 1434123:MSVAZ_RS18205
uniprot id: A0A0E3LIB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1434123:MSVAZ RS00735
gene id: 1434123:MSVAZ_RS00735
uniprot id: A0A0E3Q2L4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1434123:MSVAZ RS04080
gene id: 1434123:MSVAZ_RS04080
uniprot id: A0A0E3Q3M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434123:MSVAZ RS06695
gene id: 1434123:MSVAZ_RS06695
uniprot id: A0A0E3LH25
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS08030
gene id: 1434123:MSVAZ_RS08030
uniprot id: A0A0E3LH76
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1434123:MSVAZ RS17635
gene id: 1434123:MSVAZ_RS17635
uniprot id: A0A0E3LI89
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1434123:MSVAZ RS11410
gene id: 1434123:MSVAZ_RS11410
uniprot id: A0A0E3Q6Q2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434123:MSVAZ RS13275
gene id: 1434123:MSVAZ_RS13275
uniprot id: A0A0E3Q7C1
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS08000
gene id: 1434123:MSVAZ_RS08000
uniprot id: A0A0E3Q569
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1434123:MSVAZ RS16055
gene id: 1434123:MSVAZ_RS16055
uniprot id: A0A0E3Q8P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS08470
gene id: 1434123:MSVAZ_RS08470
uniprot id: A0A0E3Q5B9
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1434123:MSVAZ RS10620
gene id: 1434123:MSVAZ_RS10620
uniprot id: A0A0E3Q6W2
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1434123:MSVAZ RS17405
gene id: 1434123:MSVAZ_RS17405
uniprot id: A0A0E3Q8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434123:MSVAZ RS16530
gene id: 1434123:MSVAZ_RS16530
uniprot id: A0A0E3Q8F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1434123:MSVAZ RS07940
gene id: 1434123:MSVAZ_RS07940
uniprot id: A0A0E3Q5Q0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02765
gene id: 1434123:MSVAZ_RS02765
uniprot id: A0A0E3LGM7
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1434123:MSVAZ RS16280
gene id: 1434123:MSVAZ_RS16280
uniprot id: A0A0E3Q6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

1434123:MSVAZ RS08140
gene id: 1434123:MSVAZ_RS08140
uniprot id: A0A0E3Q5D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1434123:MSVAZ RS16110
gene id: 1434123:MSVAZ_RS16110
uniprot id: A0A0E3Q954
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1434123:MSVAZ RS18950
gene id: 1434123:MSVAZ_RS18950
uniprot id: A0A0E3Q7G3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434123:MSVAZ RS07130
gene id: 1434123:MSVAZ_RS07130
uniprot id: A0A0E3Q4K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1434123:MSVAZ RS18080
gene id: 1434123:MSVAZ_RS18080
uniprot id: A0A0E3Q9P8
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

1434123:MSVAZ RS02215
gene id: 1434123:MSVAZ_RS02215
uniprot id: A0A0E3Q0M6
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS02715
gene id: 1434123:MSVAZ_RS02715
uniprot id: A0A0E3Q2J6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1434123:MSVAZ RS09045
gene id: 1434123:MSVAZ_RS09045
uniprot id: A0A0E3Q5C6
names: Similarity
messages: Belongs to the class-I fumarase family.

1434123:MSVAZ RS13635
gene id: 1434123:MSVAZ_RS13635
uniprot id: A0A0E3LHT7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

1434123:MSVAZ RS15040
gene id: 1434123:MSVAZ_RS15040
uniprot id: A0A0E3Q8B9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS04965
gene id: 1434123:MSVAZ_RS04965
uniprot id: A0A0E3Q3W1
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS06525
gene id: 1434123:MSVAZ_RS06525
uniprot id: A0A0E3LH19
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434123:MSVAZ RS08345
gene id: 1434123:MSVAZ_RS08345
uniprot id: A0A0E3LH88
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1434123:MSVAZ RS17410
gene id: 1434123:MSVAZ_RS17410
uniprot id: A0A0E3Q7F1
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS08475
gene id: 1434123:MSVAZ_RS08475
uniprot id: A0A0E3Q532
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS08995
gene id: 1434123:MSVAZ_RS08995
uniprot id: A0A0E3Q5P4
names: Similarity
messages: Belongs to the sulfatase family.

1434123:MSVAZ RS00725
gene id: 1434123:MSVAZ_RS00725
uniprot id: A0A0E3Q041
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434123:MSVAZ RS13705
gene id: 1434123:MSVAZ_RS13705
uniprot id: A0A0E3Q7N3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1434123:MSVAZ RS03665
gene id: 1434123:MSVAZ_RS03665
uniprot id: A0A0E3Q3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434123:MSVAZ RS18050
gene id: 1434123:MSVAZ_RS18050
uniprot id: A0A0E3QA28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

1434123:MSVAZ RS11415
gene id: 1434123:MSVAZ_RS11415
uniprot id: A0A0E3Q774
names: Similarity
messages: Belongs to the HsdR family.

1434123:MSVAZ RS13570
gene id: 1434123:MSVAZ_RS13570
uniprot id: A0A0E3Q7J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

1434123:MSVAZ RS17860
gene id: 1434123:MSVAZ_RS17860
uniprot id: A0A0E3LI97
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1434123:MSVAZ RS02945
gene id: 1434123:MSVAZ_RS02945
uniprot id: A0A0E3Q0Y9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1434123:MSVAZ RS13810
gene id: 1434123:MSVAZ_RS13810
uniprot id: A0A0E3Q8A6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434123:MSVAZ RS11290
gene id: 1434123:MSVAZ_RS11290
uniprot id: A0A0E3Q756
names: Similarity
messages: Belongs to the peptidase C40 family.

1434123:MSVAZ RS06935
gene id: 1434123:MSVAZ_RS06935
uniprot id: A0A0E3Q2S9
names: Similarity
messages: Belongs to the DNase I family.

1434123:MSVAZ RS11385
gene id: 1434123:MSVAZ_RS11385
uniprot id: A0A0E3Q769
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1434123:MSVAZ RS08135
gene id: 1434123:MSVAZ_RS08135
uniprot id: A0A0E3Q3A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1434123:MSVAZ RS15470
gene id: 1434123:MSVAZ_RS15470
uniprot id: A0A0E3Q8J6
names: Similarity
messages: Belongs to the peptidase S49 family.

1434123:MSVAZ RS13980
gene id: 1434123:MSVAZ_RS13980
uniprot id: A0A0E3LHV0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1434123:MSVAZ RS15090
gene id: 1434123:MSVAZ_RS15090
uniprot id: A0A0E3Q881
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS16565
gene id: 1434123:MSVAZ_RS16565
uniprot id: A0A0E3Q6Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1434123:MSVAZ RS08815
gene id: 1434123:MSVAZ_RS08815
uniprot id: A0A0E3Q5M3
names: Similarity
messages: Belongs to the UPF0252 family.

1434123:MSVAZ RS02400
gene id: 1434123:MSVAZ_RS02400
uniprot id: A0A0E3Q2T3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS03450
gene id: 1434123:MSVAZ_RS03450
uniprot id: A0A0E3Q2V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1434123:MSVAZ RS12530
gene id: 1434123:MSVAZ_RS12530
uniprot id: A0A0E3LHP5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1434123:MSVAZ RS17020
gene id: 1434123:MSVAZ_RS17020
uniprot id: A0A0E3Q975
names: Similarity
messages: Belongs to the UPF0251 family.

1434123:MSVAZ RS09575
gene id: 1434123:MSVAZ_RS09575
uniprot id: A0A0E3Q3W6
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1434123:MSVAZ RS06240
gene id: 1434123:MSVAZ_RS06240
uniprot id: A0A0E3Q444
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1434123:MSVAZ RS04060
gene id: 1434123:MSVAZ_RS04060
uniprot id: A0A0E3Q3I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434123:MSVAZ RS04680
gene id: 1434123:MSVAZ_RS04680
uniprot id: A0A0E3Q1R5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1434123:MSVAZ RS15765
gene id: 1434123:MSVAZ_RS15765
uniprot id: A0A0E3Q6L1
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS06400
gene id: 1434123:MSVAZ_RS06400
uniprot id: A0A0E3Q4F2
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1434123:MSVAZ RS13760
gene id: 1434123:MSVAZ_RS13760
uniprot id: A0A0E3Q7H8
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1434123:MSVAZ RS04700
gene id: 1434123:MSVAZ_RS04700
uniprot id: A0A0E3LGV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434123:MSVAZ RS12875
gene id: 1434123:MSVAZ_RS12875
uniprot id: A0A0E3Q7T3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS12760
gene id: 1434123:MSVAZ_RS12760
uniprot id: A0A0E3Q745
names: Similarity
messages: Belongs to the UPF0280 family.

1434123:MSVAZ RS09945
gene id: 1434123:MSVAZ_RS09945
uniprot id: A0A0E3LHE9
names: Similarity
messages: Belongs to the TPP enzyme family.

1434123:MSVAZ RS07565
gene id: 1434123:MSVAZ_RS07565
uniprot id: A0A0E3Q501
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434123:MSVAZ RS12695
gene id: 1434123:MSVAZ_RS12695
uniprot id: A0A0E3Q737
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS11355
gene id: 1434123:MSVAZ_RS11355
uniprot id: A0A0E3Q765
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS13300
gene id: 1434123:MSVAZ_RS13300
uniprot id: A0A0E3Q802
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS13925
gene id: 1434123:MSVAZ_RS13925
uniprot id: A0A0E3LHU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1434123:MSVAZ RS02540
gene id: 1434123:MSVAZ_RS02540
uniprot id: A0A0E3Q3C8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434123:MSVAZ RS16020
gene id: 1434123:MSVAZ_RS16020
uniprot id: A0A0E3LI26
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434123:MSVAZ RS03235
gene id: 1434123:MSVAZ_RS03235
uniprot id: A0A0E3Q137
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434123:MSVAZ RS06225
gene id: 1434123:MSVAZ_RS06225
uniprot id: A0A0E3Q4H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434123:MSVAZ RS08005
gene id: 1434123:MSVAZ_RS08005
uniprot id: A0A0E3LH75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1434123:MSVAZ RS11775
gene id: 1434123:MSVAZ_RS11775
uniprot id: A0A0E3LHL8
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1434123:MSVAZ RS16010
gene id: 1434123:MSVAZ_RS16010
uniprot id: A0A0E3Q8S0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434123:MSVAZ RS03400
gene id: 1434123:MSVAZ_RS03400
uniprot id: A0A0E3Q3A8
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1434123:MSVAZ RS16015
gene id: 1434123:MSVAZ_RS16015
uniprot id: A0A0E3Q944
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434123:MSVAZ RS06340
gene id: 1434123:MSVAZ_RS06340
uniprot id: A0A0E3Q456
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1434123:MSVAZ RS17795
gene id: 1434123:MSVAZ_RS17795
uniprot id: A0A0E3Q9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

1434123:MSVAZ RS02810
gene id: 1434123:MSVAZ_RS02810
uniprot id: A0A0E3Q0W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS07335
gene id: 1434123:MSVAZ_RS07335
uniprot id: A0A0E3LH50
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1434123:MSVAZ RS17395
gene id: 1434123:MSVAZ_RS17395
uniprot id: A0A0E3Q9D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1434123:MSVAZ RS03865
gene id: 1434123:MSVAZ_RS03865
uniprot id: A0A0E3Q3Z8
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS16880
gene id: 1434123:MSVAZ_RS16880
uniprot id: A0A0E3Q9K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434123:MSVAZ RS04795
gene id: 1434123:MSVAZ_RS04795
uniprot id: A0A0E3Q3H8
names: Similarity
messages: Belongs to the Fur family.

1434123:MSVAZ RS15305
gene id: 1434123:MSVAZ_RS15305
uniprot id: A0A0E3LHZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS17570
gene id: 1434123:MSVAZ_RS17570
uniprot id: A0A0E3Q9F2
names: Similarity
messages: Belongs to the UPF0166 family.

1434123:MSVAZ RS18215
gene id: 1434123:MSVAZ_RS18215
uniprot id: A0A0E3Q7Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1434123:MSVAZ RS04250
gene id: 1434123:MSVAZ_RS04250
uniprot id: A0A0E3Q3K8
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

1434123:MSVAZ RS13440
gene id: 1434123:MSVAZ_RS13440
uniprot id: A0A0E3LHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1434123:MSVAZ RS04635
gene id: 1434123:MSVAZ_RS04635
uniprot id: A0A0E3Q3R9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS17470
gene id: 1434123:MSVAZ_RS17470
uniprot id: A0A0E3Q8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS00280
gene id: 1434123:MSVAZ_RS00280
uniprot id: A0A0E3Q233
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1434123:MSVAZ RS08760
gene id: 1434123:MSVAZ_RS08760
uniprot id: A0A0E3Q5G3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS02865
gene id: 1434123:MSVAZ_RS02865
uniprot id: A0A0E3Q2Z2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1434123:MSVAZ RS07700
gene id: 1434123:MSVAZ_RS07700
uniprot id: A0A0E3LH64
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1434123:MSVAZ RS17100
gene id: 1434123:MSVAZ_RS17100
uniprot id: A0A0E3Q9B2
names: Similarity
messages: Belongs to the glutamate synthase family.

1434123:MSVAZ RS10720
gene id: 1434123:MSVAZ_RS10720
uniprot id: A0A0E3Q6X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS04245
gene id: 1434123:MSVAZ_RS04245
uniprot id: A0A0E3Q459
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1434123:MSVAZ RS17040
gene id: 1434123:MSVAZ_RS17040
uniprot id: A0A0E3Q9A2
names: Similarity
messages: Belongs to the HdrC family.

1434123:MSVAZ RS02885
gene id: 1434123:MSVAZ_RS02885
uniprot id: A0A0E3Q0X8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1434123:MSVAZ RS12040
gene id: 1434123:MSVAZ_RS12040
uniprot id: A0A0E3Q6U9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1434123:MSVAZ RS16525
gene id: 1434123:MSVAZ_RS16525
uniprot id: A0A0E3Q8Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434123:MSVAZ RS11795
gene id: 1434123:MSVAZ_RS11795
uniprot id: A0A0E3Q6N6
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS06135
gene id: 1434123:MSVAZ_RS06135
uniprot id: A0A0E3Q4C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1434123:MSVAZ RS12935
gene id: 1434123:MSVAZ_RS12935
uniprot id: A0A0E3Q7B3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1434123:MSVAZ RS09250
gene id: 1434123:MSVAZ_RS09250
uniprot id: A0A0E3Q3R8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS16600
gene id: 1434123:MSVAZ_RS16600
uniprot id: A0A0E3Q6Z5
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1434123:MSVAZ RS09440
gene id: 1434123:MSVAZ_RS09440
uniprot id: A0A0E3Q5J0
names: Similarity
messages: Belongs to the glutaredoxin family.

1434123:MSVAZ RS13430
gene id: 1434123:MSVAZ_RS13430
uniprot id: A0A0E3Q834
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1434123:MSVAZ RS15990
gene id: 1434123:MSVAZ_RS15990
uniprot id: A0A0E3Q8N5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434123:MSVAZ RS09005
gene id: 1434123:MSVAZ_RS09005
uniprot id: A0A0E3Q631
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434123:MSVAZ RS16145
gene id: 1434123:MSVAZ_RS16145
uniprot id: A0A0E3LI31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

1434123:MSVAZ RS03460
gene id: 1434123:MSVAZ_RS03460
uniprot id: A0A0E3LGQ3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1434123:MSVAZ RS16400
gene id: 1434123:MSVAZ_RS16400
uniprot id: A0A0E3Q8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1434123:MSVAZ RS10135
gene id: 1434123:MSVAZ_RS10135
uniprot id: A0A0E3Q619
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS03115
gene id: 1434123:MSVAZ_RS03115
uniprot id: A0A0E3Q3K2
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS07660
gene id: 1434123:MSVAZ_RS07660
uniprot id: A0A0E3Q334
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1434123:MSVAZ RS04045
gene id: 1434123:MSVAZ_RS04045
uniprot id: A0A0E3Q1H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434123:MSVAZ RS04115
gene id: 1434123:MSVAZ_RS04115
uniprot id: A0A0E3LGS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS16415
gene id: 1434123:MSVAZ_RS16415
uniprot id: A0A0E3Q8Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1434123:MSVAZ RS06900
gene id: 1434123:MSVAZ_RS06900
uniprot id: A0A0E3Q2S4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1434123:MSVAZ RS04685
gene id: 1434123:MSVAZ_RS04685
uniprot id: A0A0E3Q3V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1434123:MSVAZ RS05575
gene id: 1434123:MSVAZ_RS05575
uniprot id: A0A0E3Q450
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1434123:MSVAZ RS18585
gene id: 1434123:MSVAZ_RS18585
uniprot id: A0A0E3Q9T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

1434123:MSVAZ RS11685
gene id: 1434123:MSVAZ_RS11685
uniprot id: A0A0E3Q4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS01500
gene id: 1434123:MSVAZ_RS01500
uniprot id: A0A0E3Q0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434123:MSVAZ RS00425
gene id: 1434123:MSVAZ_RS00425
uniprot id: A0A0E3Q217
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

1434123:MSVAZ RS13055
gene id: 1434123:MSVAZ_RS13055
uniprot id: A0A0E3Q787
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1434123:MSVAZ RS01565
gene id: 1434123:MSVAZ_RS01565
uniprot id: A0A0E3Q2K8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1434123:MSVAZ RS06920
gene id: 1434123:MSVAZ_RS06920
uniprot id: A0A0E3Q4Q1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS00980
gene id: 1434123:MSVAZ_RS00980
uniprot id: A0A0E3Q2D4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1434123:MSVAZ RS06130
gene id: 1434123:MSVAZ_RS06130
uniprot id: A0A0E3Q4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1434123:MSVAZ RS09360
gene id: 1434123:MSVAZ_RS09360
uniprot id: A0A0E3Q5T0
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS15540
gene id: 1434123:MSVAZ_RS15540
uniprot id: A0A0E3Q8X7
names: Similarity
messages: Belongs to the AAA ATPase family.

1434123:MSVAZ RS14135
gene id: 1434123:MSVAZ_RS14135
uniprot id: A0A0E3Q7M0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05215
gene id: 1434123:MSVAZ_RS05215
uniprot id: A0A0E3Q1Y1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434123:MSVAZ RS11835
gene id: 1434123:MSVAZ_RS11835
uniprot id: A0A0E3Q6P0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434123:MSVAZ RS07995
gene id: 1434123:MSVAZ_RS07995
uniprot id: A0A0E3Q5Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1434123:MSVAZ RS04715
gene id: 1434123:MSVAZ_RS04715
uniprot id: A0A0E3Q3V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1434123:MSVAZ RS00955
gene id: 1434123:MSVAZ_RS00955
uniprot id: A0A0E3Q2P5
names: Similarity
messages: Belongs to the UPF0677 family.

1434123:MSVAZ RS02955
gene id: 1434123:MSVAZ_RS02955
uniprot id: A0A0E3Q337
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1434123:MSVAZ RS04090
gene id: 1434123:MSVAZ_RS04090
uniprot id: A0A0E3LGS6
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1434123:MSVAZ RS04875
gene id: 1434123:MSVAZ_RS04875
uniprot id: A0A0E3Q3I9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS09420
gene id: 1434123:MSVAZ_RS09420
uniprot id: A0A0E3LHC8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1434123:MSVAZ RS04645
gene id: 1434123:MSVAZ_RS04645
uniprot id: A0A0E3Q1R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1434123:MSVAZ RS12940
gene id: 1434123:MSVAZ_RS12940
uniprot id: A0A0E3Q7U3
names: Similarity
messages: Belongs to the UPF0111 family.

1434123:MSVAZ RS05225
gene id: 1434123:MSVAZ_RS05225
uniprot id: A0A0E3Q4J2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1434123:MSVAZ RS17625
gene id: 1434123:MSVAZ_RS17625
uniprot id: A0A0E3Q9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1434123:MSVAZ RS14555
gene id: 1434123:MSVAZ_RS14555
uniprot id: A0A0E3Q7Y5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1434123:MSVAZ RS12455
gene id: 1434123:MSVAZ_RS12455
uniprot id: A0A0E3LHP2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1434123:MSVAZ RS04265
gene id: 1434123:MSVAZ_RS04265
uniprot id: A0A0E3LGT3
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434123:MSVAZ RS00370
gene id: 1434123:MSVAZ_RS00370
uniprot id: A0A0E3Q004
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434123:MSVAZ RS05640
gene id: 1434123:MSVAZ_RS05640
uniprot id: A0A0E3Q3U9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434123:MSVAZ RS14550
gene id: 1434123:MSVAZ_RS14550
uniprot id: A0A0E3LHX1
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1434123:MSVAZ RS11785
gene id: 1434123:MSVAZ_RS11785
uniprot id: A0A0E3Q7C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434123:MSVAZ RS13135
gene id: 1434123:MSVAZ_RS13135
uniprot id: A0A0E3Q5F9
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

1434123:MSVAZ RS09265
gene id: 1434123:MSVAZ_RS09265
uniprot id: A0A0E3Q660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434123:MSVAZ RS10460
gene id: 1434123:MSVAZ_RS10460
uniprot id: A0A0E3Q645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1434123:MSVAZ RS03945
gene id: 1434123:MSVAZ_RS03945
uniprot id: A0A0E3Q350
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1434123:MSVAZ RS18600
gene id: 1434123:MSVAZ_RS18600
uniprot id: A0A0E3Q7W1
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

1434123:MSVAZ RS12340
gene id: 1434123:MSVAZ_RS12340
uniprot id: A0A0E3Q6Y9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS00465
gene id: 1434123:MSVAZ_RS00465
uniprot id: A0A0E3Q1M6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1434123:MSVAZ RS08560
gene id: 1434123:MSVAZ_RS08560
uniprot id: A0A0E3Q5Y1
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1434123:MSVAZ RS03935
gene id: 1434123:MSVAZ_RS03935
uniprot id: A0A0E3Q3G0
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1434123:MSVAZ RS06140
gene id: 1434123:MSVAZ_RS06140
uniprot id: A0A0E3LH05
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1434123:MSVAZ RS06105
gene id: 1434123:MSVAZ_RS06105
uniprot id: A0A0E3Q4W1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1434123:MSVAZ RS01280
gene id: 1434123:MSVAZ_RS01280
uniprot id: A0A0E3Q1Y3
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1434123:MSVAZ RS20710
gene id: 1434123:MSVAZ_RS20710
uniprot id: A0A0E3Q3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

1434123:MSVAZ RS16095
gene id: 1434123:MSVAZ_RS16095
uniprot id: A0A0E3LI29
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS16425
gene id: 1434123:MSVAZ_RS16425
uniprot id: A0A0E3Q9A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1434123:MSVAZ RS02395
gene id: 1434123:MSVAZ_RS02395
uniprot id: A0A0E3Q3B3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS10365
gene id: 1434123:MSVAZ_RS10365
uniprot id: A0A0E3Q6S2
names: Similarity
messages: Belongs to the oxoprolinase family.

1434123:MSVAZ RS01560
gene id: 1434123:MSVAZ_RS01560
uniprot id: A0A0E3Q0E3
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1434123:MSVAZ RS17355
gene id: 1434123:MSVAZ_RS17355
uniprot id: A0A0E3Q9C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS10300
gene id: 1434123:MSVAZ_RS10300
uniprot id: A0A0E3LHG2
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1434123:MSVAZ RS11480
gene id: 1434123:MSVAZ_RS11480
uniprot id: A0A0E3LHK7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434123:MSVAZ RS07605
gene id: 1434123:MSVAZ_RS07605
uniprot id: A0A0E3Q325
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1434123:MSVAZ RS02835
gene id: 1434123:MSVAZ_RS02835
uniprot id: A0A0E3Q2L3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1434123:MSVAZ RS14870
gene id: 1434123:MSVAZ_RS14870
uniprot id: A0A0E3Q7W9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434123:MSVAZ RS12740
gene id: 1434123:MSVAZ_RS12740
uniprot id: A0A0E3LHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS00535
gene id: 1434123:MSVAZ_RS00535
uniprot id: A0A0E3Q019
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1434123:MSVAZ RS13060
gene id: 1434123:MSVAZ_RS13060
uniprot id: A0A0E3LHR5
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

1434123:MSVAZ RS08750
gene id: 1434123:MSVAZ_RS08750
uniprot id: A0A0E3Q5L6
names: Similarity
messages: Belongs to the UPF0047 family.

1434123:MSVAZ RS07630
gene id: 1434123:MSVAZ_RS07630
uniprot id: A0A0E3Q4S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1434123:MSVAZ RS01785
gene id: 1434123:MSVAZ_RS01785
uniprot id: A0A0E3Q312
names: Similarity
messages: Belongs to the peptidase C1 family.

1434123:MSVAZ RS15350
gene id: 1434123:MSVAZ_RS15350
uniprot id: A0A0E3Q8U5
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS03720
gene id: 1434123:MSVAZ_RS03720
uniprot id: A0A0E3LGR3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS00925
gene id: 1434123:MSVAZ_RS00925
uniprot id: A0A0E3Q2P1
names: Similarity
messages: Belongs to the thymidylate kinase family.

1434123:MSVAZ RS05270
gene id: 1434123:MSVAZ_RS05270
uniprot id: A0A0E3Q3P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434123:MSVAZ RS06155
gene id: 1434123:MSVAZ_RS06155
uniprot id: A0A0E3Q4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434123:MSVAZ RS00565
gene id: 1434123:MSVAZ_RS00565
uniprot id: A0A0E3Q023
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434123:MSVAZ RS03340
gene id: 1434123:MSVAZ_RS03340
uniprot id: A0A0E3Q3N9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS15230
gene id: 1434123:MSVAZ_RS15230
uniprot id: A0A0E3Q819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1434123:MSVAZ RS01520
gene id: 1434123:MSVAZ_RS01520
uniprot id: A0A0E3LGI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434123:MSVAZ RS17985
gene id: 1434123:MSVAZ_RS17985
uniprot id: A0A0E3LIA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1434123:MSVAZ RS15595
gene id: 1434123:MSVAZ_RS15595
uniprot id: A0A0E3Q6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434123:MSVAZ RS08070
gene id: 1434123:MSVAZ_RS08070
uniprot id: A0A0E3Q4X3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS03180
gene id: 1434123:MSVAZ_RS03180
uniprot id: A0A0E3Q3L4
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS16060
gene id: 1434123:MSVAZ_RS16060
uniprot id: A0A0E3Q8A4
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS16575
gene id: 1434123:MSVAZ_RS16575
uniprot id: A0A0E3Q910
names: Similarity
messages: Belongs to the UPF0292 family.

1434123:MSVAZ RS02110
gene id: 1434123:MSVAZ_RS02110
uniprot id: A0A0E3Q366
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS05560
gene id: 1434123:MSVAZ_RS05560
uniprot id: A0A0E3Q483
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434123:MSVAZ RS10100
gene id: 1434123:MSVAZ_RS10100
uniprot id: A0A0E3Q614
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1434123:MSVAZ RS08795
gene id: 1434123:MSVAZ_RS08795
uniprot id: A0A0E3Q5G7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS01640
gene id: 1434123:MSVAZ_RS01640
uniprot id: A0A0E3Q2Z3
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1434123:MSVAZ RS10670
gene id: 1434123:MSVAZ_RS10670
uniprot id: A0A0E3Q672
names: Function
names: Subcellular Location Annotation
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

1434123:MSVAZ RS16610
gene id: 1434123:MSVAZ_RS16610
uniprot id: A0A0E3Q9D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1434123:MSVAZ RS16165
gene id: 1434123:MSVAZ_RS16165
uniprot id: A0A0E3Q8U4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1434123:MSVAZ RS15315
gene id: 1434123:MSVAZ_RS15315
uniprot id: A0A0E3Q8G8
names: Similarity
messages: Belongs to the PurH family.

1434123:MSVAZ RS15285
gene id: 1434123:MSVAZ_RS15285
uniprot id: A0A0E3Q8G4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS08600
gene id: 1434123:MSVAZ_RS08600
uniprot id: A0A0E3Q5Y4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1434123:MSVAZ RS15330
gene id: 1434123:MSVAZ_RS15330
uniprot id: A0A0E3LI00
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS17015
gene id: 1434123:MSVAZ_RS17015
uniprot id: A0A0E3Q9M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1434123:MSVAZ RS15520
gene id: 1434123:MSVAZ_RS15520
uniprot id: A0A0E3Q848
names: Similarity
messages: Belongs to the SUI1 family.

1434123:MSVAZ RS11020
gene id: 1434123:MSVAZ_RS11020
uniprot id: A0A0E3LHI9
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS14565
gene id: 1434123:MSVAZ_RS14565
uniprot id: A0A0E3Q642
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1434123:MSVAZ RS16000
gene id: 1434123:MSVAZ_RS16000
uniprot id: A0A0E3Q4J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

1434123:MSVAZ RS11270
gene id: 1434123:MSVAZ_RS11270
uniprot id: A0A0E3Q6G7
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

1434123:MSVAZ RS14065
gene id: 1434123:MSVAZ_RS14065
uniprot id: A0A0E3Q7U1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434123:MSVAZ RS13605
gene id: 1434123:MSVAZ_RS13605
uniprot id: A0A0E3LHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1434123:MSVAZ RS18100
gene id: 1434123:MSVAZ_RS18100
uniprot id: A0A0E3Q945
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1434123:MSVAZ RS01415
gene id: 1434123:MSVAZ_RS01415
uniprot id: A0A0E3Q2V7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1434123:MSVAZ RS16230
gene id: 1434123:MSVAZ_RS16230
uniprot id: A0A0E3Q6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpK family.
messages: Gas vesicle
messages: Vesicle

1434123:MSVAZ RS13510
gene id: 1434123:MSVAZ_RS13510
uniprot id: A0A0E3Q5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1434123:MSVAZ RS01695
gene id: 1434123:MSVAZ_RS01695
uniprot id: A0A0E3Q0G3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1434123:MSVAZ RS06560
gene id: 1434123:MSVAZ_RS06560
uniprot id: A0A0E3Q480
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS05180
gene id: 1434123:MSVAZ_RS05180
uniprot id: A0A0E3Q1X7
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS18140
gene id: 1434123:MSVAZ_RS18140
uniprot id: A0A0E3LIA8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434123:MSVAZ RS02840
gene id: 1434123:MSVAZ_RS02840
uniprot id: A0A0E3LGM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434123:MSVAZ RS11110
gene id: 1434123:MSVAZ_RS11110
uniprot id: A0A0E3Q6E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1434123:MSVAZ RS02280
gene id: 1434123:MSVAZ_RS02280
uniprot id: A0A0E3LGK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1434123:MSVAZ RS09835
gene id: 1434123:MSVAZ_RS09835
uniprot id: A0A0E3Q6F2
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1434123:MSVAZ RS05275
gene id: 1434123:MSVAZ_RS05275
uniprot id: A0A0E3Q1Y7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434123:MSVAZ RS17845
gene id: 1434123:MSVAZ_RS17845
uniprot id: A0A0E3Q916
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1434123:MSVAZ RS05080
gene id: 1434123:MSVAZ_RS05080
uniprot id: A0A0E3LGW4
names: Similarity
messages: Belongs to the P(II) protein family.

1434123:MSVAZ RS05255
gene id: 1434123:MSVAZ_RS05255
uniprot id: A0A0E3Q4J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

1434123:MSVAZ RS07175
gene id: 1434123:MSVAZ_RS07175
uniprot id: A0A0E3Q4Z8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1434123:MSVAZ RS04105
gene id: 1434123:MSVAZ_RS04105
uniprot id: A0A0E3Q1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1434123:MSVAZ RS17385
gene id: 1434123:MSVAZ_RS17385
uniprot id: A0A0E3Q9T7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1434123:MSVAZ RS11115
gene id: 1434123:MSVAZ_RS11115
uniprot id: A0A0E3Q4M4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434123:MSVAZ RS11030
gene id: 1434123:MSVAZ_RS11030
uniprot id: A0A0E3Q6K1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1434123:MSVAZ RS18075
gene id: 1434123:MSVAZ_RS18075
uniprot id: A0A0E3Q7P0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434123:MSVAZ RS07420
gene id: 1434123:MSVAZ_RS07420
uniprot id: A0A0E3Q5I4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434123:MSVAZ RS03640
gene id: 1434123:MSVAZ_RS03640
uniprot id: A0A0E3LGR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1434123:MSVAZ RS15535
gene id: 1434123:MSVAZ_RS15535
uniprot id: A0A0E3Q8K4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1434123:MSVAZ RS16285
gene id: 1434123:MSVAZ_RS16285
uniprot id: A0A0E3Q6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

1434123:MSVAZ RS05070
gene id: 1434123:MSVAZ_RS05070
uniprot id: A0A0E3Q3X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434123:MSVAZ RS03600
gene id: 1434123:MSVAZ_RS03600
uniprot id: A0A0E3Q3W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1434123:MSVAZ RS11500
gene id: 1434123:MSVAZ_RS11500
uniprot id: A0A0E3Q4S6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1434123:MSVAZ RS07120
gene id: 1434123:MSVAZ_RS07120
uniprot id: A0A0E3Q5E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1434123:MSVAZ RS17165
gene id: 1434123:MSVAZ_RS17165
uniprot id: A0A0E3LI71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS07970
gene id: 1434123:MSVAZ_RS07970
uniprot id: A0A0E3Q563
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1434123:MSVAZ RS05250
gene id: 1434123:MSVAZ_RS05250
uniprot id: A0A0E3LI25
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

1434123:MSVAZ RS10960
gene id: 1434123:MSVAZ_RS10960
uniprot id: A0A0E3Q4K2
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS10765
gene id: 1434123:MSVAZ_RS10765
uniprot id: A0A0E3Q6C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434123:MSVAZ RS14865
gene id: 1434123:MSVAZ_RS14865
uniprot id: A0A0E3Q841
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434123:MSVAZ RS15995
gene id: 1434123:MSVAZ_RS15995
uniprot id: A0A0E3LI25
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

1434123:MSVAZ RS17280
gene id: 1434123:MSVAZ_RS17280
uniprot id: A0A0E3Q9S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1434123:MSVAZ RS12060
gene id: 1434123:MSVAZ_RS12060
uniprot id: A0A0E3Q6Z2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434123:MSVAZ RS17895
gene id: 1434123:MSVAZ_RS17895
uniprot id: A0A0E3QA05
names: Similarity
messages: Belongs to the aspartokinase family.

1434123:MSVAZ RS18115
gene id: 1434123:MSVAZ_RS18115
uniprot id: A0A0E3LIA7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1434123:MSVAZ RS05105
gene id: 1434123:MSVAZ_RS05105
uniprot id: A0A0E3LGW5
names: Similarity
messages: Belongs to the pyruvate kinase family.

1434123:MSVAZ RS12295
gene id: 1434123:MSVAZ_RS12295
uniprot id: A0A0E3Q722
names: Subcellular Location Annotation
messages: Cell membrane

1434123:MSVAZ RS07345
gene id: 1434123:MSVAZ_RS07345
uniprot id: A0A0E3Q2Z4
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

1434123:MSVAZ RS04670
gene id: 1434123:MSVAZ_RS04670
uniprot id: A0A0E3Q3F9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1434123:MSVAZ RS17145
gene id: 1434123:MSVAZ_RS17145
uniprot id: A0A0E3Q8S3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS08025
gene id: 1434123:MSVAZ_RS08025
uniprot id: A0A0E3Q5R3
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1434123:MSVAZ RS00670
gene id: 1434123:MSVAZ_RS00670
uniprot id: A0A0E3LGE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1434123:MSVAZ RS11745
gene id: 1434123:MSVAZ_RS11745
uniprot id: A0A0E3Q6V1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS06855
gene id: 1434123:MSVAZ_RS06855
uniprot id: A0A0E3LH31
names: Similarity
messages: Belongs to the glutamine synthetase family.

1434123:MSVAZ RS09425
gene id: 1434123:MSVAZ_RS09425
uniprot id: A0A0E3Q5T9
names: Similarity
messages: Belongs to the UPF0212 family.

1434123:MSVAZ RS10260
gene id: 1434123:MSVAZ_RS10260
uniprot id: A0A0E3Q609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1434123:MSVAZ RS04260
gene id: 1434123:MSVAZ_RS04260
uniprot id: A0A0E3Q1K6
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434123:MSVAZ RS16615
gene id: 1434123:MSVAZ_RS16615
uniprot id: A0A0E3Q900
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1434123:MSVAZ RS02610
gene id: 1434123:MSVAZ_RS02610
uniprot id: A0A0E3Q3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1434123:MSVAZ RS06465
gene id: 1434123:MSVAZ_RS06465
uniprot id: A0A0E3Q522
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434123:MSVAZ RS02815
gene id: 1434123:MSVAZ_RS02815
uniprot id: A0A0E3LGM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS06150
gene id: 1434123:MSVAZ_RS06150
uniprot id: A0A0E3Q2C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434123:MSVAZ RS01115
gene id: 1434123:MSVAZ_RS01115
uniprot id: A0A0E3Q2E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434123:MSVAZ RS00210
gene id: 1434123:MSVAZ_RS00210
uniprot id: A0A0E3PZV2
names: Similarity
messages: Belongs to the UPF0200 family.

1434123:MSVAZ RS10345
gene id: 1434123:MSVAZ_RS10345
uniprot id: A0A0E3Q624
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS14320
gene id: 1434123:MSVAZ_RS14320
uniprot id: A0A0E3Q7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1434123:MSVAZ RS05175
gene id: 1434123:MSVAZ_RS05175
uniprot id: A0A0E3Q3N0
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434123:MSVAZ RS01675
gene id: 1434123:MSVAZ_RS01675
uniprot id: A0A0E3LGI6
names: Similarity
messages: Belongs to the UPF0107 family.

1434123:MSVAZ RS03635
gene id: 1434123:MSVAZ_RS03635
uniprot id: A0A0E3Q3D4
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1434123:MSVAZ RS16500
gene id: 1434123:MSVAZ_RS16500
uniprot id: A0A0E3LI45
names: Similarity
messages: Belongs to the PDCD5 family.

1434123:MSVAZ RS05140
gene id: 1434123:MSVAZ_RS05140
uniprot id: A0A0E3Q3Y3
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS17830
gene id: 1434123:MSVAZ_RS17830
uniprot id: A0A0E3Q9Z9
names: Subcellular Location Annotation
messages: Membrane

1434123:MSVAZ RS01310
gene id: 1434123:MSVAZ_RS01310
uniprot id: A0A0E3Q0A7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane