1434120:MSSIT RS08165
gene id: 1434120:MSSIT_RS08165
uniprot id: A0A0E3P449
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1434120:MSSIT RS07500
gene id: 1434120:MSSIT_RS07500
uniprot id: A0A0E3P3V0
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

1434120:MSSIT RS05295
gene id: 1434120:MSSIT_RS05295
uniprot id: A0A0E3P2J3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1434120:MSSIT RS15670
gene id: 1434120:MSSIT_RS15670
uniprot id: A0A0E3P755
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS12605
gene id: 1434120:MSSIT_RS12605
uniprot id: A0A0E3P5W2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1434120:MSSIT RS01895
gene id: 1434120:MSSIT_RS01895
uniprot id: A0A0E3P1F6
names: Similarity
messages: Belongs to the LarC family.

1434120:MSSIT RS10765
gene id: 1434120:MSSIT_RS10765
uniprot id: A0A0E3L8L7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS01230
gene id: 1434120:MSSIT_RS01230
uniprot id: A0A0E3P103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS14425
gene id: 1434120:MSSIT_RS14425
uniprot id: A0A0E3P6M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS14930
gene id: 1434120:MSSIT_RS14930
uniprot id: A0A0E3P6V3
names: Similarity
messages: Belongs to the UPF0237 family.

1434120:MSSIT RS00465
gene id: 1434120:MSSIT_RS00465
uniprot id: A0A0E3P0G8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1434120:MSSIT RS13135
gene id: 1434120:MSSIT_RS13135
uniprot id: A0A0E3P637
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1434120:MSSIT RS05540
gene id: 1434120:MSSIT_RS05540
uniprot id: A0A0E3L822
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS04400
gene id: 1434120:MSSIT_RS04400
uniprot id: A0A0E3P257
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1434120:MSSIT RS05185
gene id: 1434120:MSSIT_RS05185
uniprot id: A0A0E3P539
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS20850
gene id: 1434120:MSSIT_RS20850
uniprot id: A0A0E3P9D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS00515
gene id: 1434120:MSSIT_RS00515
uniprot id: A0A0E3P0R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1434120:MSSIT RS06340
gene id: 1434120:MSSIT_RS06340
uniprot id: A0A0E3L853
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434120:MSSIT RS19000
gene id: 1434120:MSSIT_RS19000
uniprot id: A0A0E3L9I2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1434120:MSSIT RS15990
gene id: 1434120:MSSIT_RS15990
uniprot id: A0A0E3P795
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434120:MSSIT RS15790
gene id: 1434120:MSSIT_RS15790
uniprot id: A0A0E3P784
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1434120:MSSIT RS17995
gene id: 1434120:MSSIT_RS17995
uniprot id: A0A0E3P834
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1434120:MSSIT RS00320
gene id: 1434120:MSSIT_RS00320
uniprot id: A0A0E3L7H3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS15835
gene id: 1434120:MSSIT_RS15835
uniprot id: A0A0E3L963
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1434120:MSSIT RS19430
gene id: 1434120:MSSIT_RS19430
uniprot id: A0A0E3P8T7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434120:MSSIT RS04805
gene id: 1434120:MSSIT_RS04805
uniprot id: A0A0E3P2G8
names: Similarity
messages: Belongs to the FrhG family.

1434120:MSSIT RS01285
gene id: 1434120:MSSIT_RS01285
uniprot id: A0A0E3P108
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS12050
gene id: 1434120:MSSIT_RS12050
uniprot id: A0A0E3P5C7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05425
gene id: 1434120:MSSIT_RS05425
uniprot id: A0A0E3L818
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

1434120:MSSIT RS08010
gene id: 1434120:MSSIT_RS08010
uniprot id: A0A0E3L8B4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1434120:MSSIT RS16655
gene id: 1434120:MSSIT_RS16655
uniprot id: A0A0E3P7L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1434120:MSSIT RS00865
gene id: 1434120:MSSIT_RS00865
uniprot id: A0A0E3L7J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1434120:MSSIT RS11760
gene id: 1434120:MSSIT_RS11760
uniprot id: A0A0E3P5H5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14480
gene id: 1434120:MSSIT_RS14480
uniprot id: A0A0E3P6S0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS01625
gene id: 1434120:MSSIT_RS01625
uniprot id: A0A0E3P3F9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS01240
gene id: 1434120:MSSIT_RS01240
uniprot id: A0A0E3P0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS20505
gene id: 1434120:MSSIT_RS20505
uniprot id: A0A0E3P9E1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1434120:MSSIT RS19360
gene id: 1434120:MSSIT_RS19360
uniprot id: A0A0E3P8W9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434120:MSSIT RS04540
gene id: 1434120:MSSIT_RS04540
uniprot id: A0A0E3P2C8
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09255
gene id: 1434120:MSSIT_RS09255
uniprot id: A0A0E3P4F5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1434120:MSSIT RS12800
gene id: 1434120:MSSIT_RS12800
uniprot id: A0A0E3P5Y0
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

1434120:MSSIT RS01720
gene id: 1434120:MSSIT_RS01720
uniprot id: A0A0E3P3H8
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS15635
gene id: 1434120:MSSIT_RS15635
uniprot id: A0A0E3P988
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS19790
gene id: 1434120:MSSIT_RS19790
uniprot id: A0A0E3PB08
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434120:MSSIT RS18565
gene id: 1434120:MSSIT_RS18565
uniprot id: A0A0E3P8B5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434120:MSSIT RS02380
gene id: 1434120:MSSIT_RS02380
uniprot id: A0A0E3L7Q2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1434120:MSSIT RS00160
gene id: 1434120:MSSIT_RS00160
uniprot id: A0A0E3P0E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1434120:MSSIT RS08220
gene id: 1434120:MSSIT_RS08220
uniprot id: A0A0E3P671
names: Function
messages: Part of a potassium transport system.

1434120:MSSIT RS01290
gene id: 1434120:MSSIT_RS01290
uniprot id: A0A0E3P150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

1434120:MSSIT RS06355
gene id: 1434120:MSSIT_RS06355
uniprot id: A0A0E3P386
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434120:MSSIT RS18000
gene id: 1434120:MSSIT_RS18000
uniprot id: A0A0E3PAA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1434120:MSSIT RS16565
gene id: 1434120:MSSIT_RS16565
uniprot id: A0A0E3P7K1
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1434120:MSSIT RS20770
gene id: 1434120:MSSIT_RS20770
uniprot id: A0A0E3L9P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434120:MSSIT RS16050
gene id: 1434120:MSSIT_RS16050
uniprot id: A0A0E3P7G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434120:MSSIT RS16085
gene id: 1434120:MSSIT_RS16085
uniprot id: A0A0E3P7H1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17985
gene id: 1434120:MSSIT_RS17985
uniprot id: A0A0E3L9E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434120:MSSIT RS05060
gene id: 1434120:MSSIT_RS05060
uniprot id: A0A0E3P2S7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1434120:MSSIT RS17890
gene id: 1434120:MSSIT_RS17890
uniprot id: A0A0E3PA93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434120:MSSIT RS15980
gene id: 1434120:MSSIT_RS15980
uniprot id: A0A0E3P9E3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS19290
gene id: 1434120:MSSIT_RS19290
uniprot id: A0A0E3L9J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS03140
gene id: 1434120:MSSIT_RS03140
uniprot id: A0A0E3P1P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1434120:MSSIT RS19560
gene id: 1434120:MSSIT_RS19560
uniprot id: A0A0E3PAU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1434120:MSSIT RS02730
gene id: 1434120:MSSIT_RS02730
uniprot id: A0A0E3P1Q8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1434120:MSSIT RS04120
gene id: 1434120:MSSIT_RS04120
uniprot id: A0A0E3P2D1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1434120:MSSIT RS13285
gene id: 1434120:MSSIT_RS13285
uniprot id: A0A0E3P661
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03050
gene id: 1434120:MSSIT_RS03050
uniprot id: A0A0E3P460
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1434120:MSSIT RS17865
gene id: 1434120:MSSIT_RS17865
uniprot id: A0A0E3P8B6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS13995
gene id: 1434120:MSSIT_RS13995
uniprot id: A0A0E3L8Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434120:MSSIT RS18570
gene id: 1434120:MSSIT_RS18570
uniprot id: A0A0E3PAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

1434120:MSSIT RS18290
gene id: 1434120:MSSIT_RS18290
uniprot id: A0A0E3P8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1434120:MSSIT RS17005
gene id: 1434120:MSSIT_RS17005
uniprot id: A0A0E3P7X7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS00595
gene id: 1434120:MSSIT_RS00595
uniprot id: A0A0E3P0I3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434120:MSSIT RS00910
gene id: 1434120:MSSIT_RS00910
uniprot id: A0A0E3P0X5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1434120:MSSIT RS08630
gene id: 1434120:MSSIT_RS08630
uniprot id: A0A0E3P468
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS08310
gene id: 1434120:MSSIT_RS08310
uniprot id: A0A0E3P685
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

1434120:MSSIT RS00005
gene id: 1434120:MSSIT_RS00005
uniprot id: A0A0E3P0C3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434120:MSSIT RS06360
gene id: 1434120:MSSIT_RS06360
uniprot id: A0A0E3P342
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1434120:MSSIT RS04435
gene id: 1434120:MSSIT_RS04435
uniprot id: A0A0E3P4Q9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS01620
gene id: 1434120:MSSIT_RS01620
uniprot id: A0A0E3L7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS16015
gene id: 1434120:MSSIT_RS16015
uniprot id: A0A0E3P7G3
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

1434120:MSSIT RS17410
gene id: 1434120:MSSIT_RS17410
uniprot id: A0A0E3L9C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS01010
gene id: 1434120:MSSIT_RS01010
uniprot id: A0A0E3P0W8
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1434120:MSSIT RS11355
gene id: 1434120:MSSIT_RS11355
uniprot id: A0A0E3L8N9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1434120:MSSIT RS00665
gene id: 1434120:MSSIT_RS00665
uniprot id: A0A0E3P0J1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS00740
gene id: 1434120:MSSIT_RS00740
uniprot id: A0A0E3P323
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

1434120:MSSIT RS01250
gene id: 1434120:MSSIT_RS01250
uniprot id: A0A0E3L7K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS07740
gene id: 1434120:MSSIT_RS07740
uniprot id: A0A0E3P3T0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434120:MSSIT RS21125
gene id: 1434120:MSSIT_RS21125
uniprot id: A0A0E3P3D1
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS17450
gene id: 1434120:MSSIT_RS17450
uniprot id: A0A0E3P844
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS00480
gene id: 1434120:MSSIT_RS00480
uniprot id: A0A0E3P0P1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1434120:MSSIT RS00650
gene id: 1434120:MSSIT_RS00650
uniprot id: A0A0E3L7I5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05865
gene id: 1434120:MSSIT_RS05865
uniprot id: A0A0E3L835
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1434120:MSSIT RS19115
gene id: 1434120:MSSIT_RS19115
uniprot id: A0A0E3L9I6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1434120:MSSIT RS07280
gene id: 1434120:MSSIT_RS07280
uniprot id: A0A0E3P3J2
names: Similarity
messages: Belongs to the UPF0677 family.

1434120:MSSIT RS08965
gene id: 1434120:MSSIT_RS08965
uniprot id: A0A0E3P3V2
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS01110
gene id: 1434120:MSSIT_RS01110
uniprot id: A0A0E3P0R2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1434120:MSSIT RS03840
gene id: 1434120:MSSIT_RS03840
uniprot id: A0A0E3P1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS20195
gene id: 1434120:MSSIT_RS20195
uniprot id: A0A0E3L9M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS19200
gene id: 1434120:MSSIT_RS19200
uniprot id: A0A0E3P8R2
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS05440
gene id: 1434120:MSSIT_RS05440
uniprot id: A0A0E3P2Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1434120:MSSIT RS02375
gene id: 1434120:MSSIT_RS02375
uniprot id: A0A0E3P3U6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1434120:MSSIT RS12200
gene id: 1434120:MSSIT_RS12200
uniprot id: A0A0E3P5P4
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1434120:MSSIT RS09245
gene id: 1434120:MSSIT_RS09245
uniprot id: A0A0E3P4D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1434120:MSSIT RS16840
gene id: 1434120:MSSIT_RS16840
uniprot id: A0A0E3P7N9
names: Subcellular Location Annotation
messages: Cytoplasm

1434120:MSSIT RS02370
gene id: 1434120:MSSIT_RS02370
uniprot id: A0A0E3P194
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1434120:MSSIT RS01635
gene id: 1434120:MSSIT_RS01635
uniprot id: A0A0E3P1A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1434120:MSSIT RS02750
gene id: 1434120:MSSIT_RS02750
uniprot id: A0A0E3P1E1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1434120:MSSIT RS15180
gene id: 1434120:MSSIT_RS15180
uniprot id: A0A0E3P6Y6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1434120:MSSIT RS21250
gene id: 1434120:MSSIT_RS21250
uniprot id: A0A0E3P577
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS05140
gene id: 1434120:MSSIT_RS05140
uniprot id: A0A0E3P2L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS15430
gene id: 1434120:MSSIT_RS15430
uniprot id: A0A0E3P707
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434120:MSSIT RS19590
gene id: 1434120:MSSIT_RS19590
uniprot id: A0A0E3L9K3
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

1434120:MSSIT RS20845
gene id: 1434120:MSSIT_RS20845
uniprot id: A0A0E3P9J1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS05900
gene id: 1434120:MSSIT_RS05900
uniprot id: A0A0E3P345
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1434120:MSSIT RS20180
gene id: 1434120:MSSIT_RS20180
uniprot id: A0A0E3P941
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12975
gene id: 1434120:MSSIT_RS12975
uniprot id: A0A0E3P5Z9
names: Similarity
messages: Belongs to the TPP enzyme family.

1434120:MSSIT RS16080
gene id: 1434120:MSSIT_RS16080
uniprot id: A0A0E3L972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1434120:MSSIT RS20370
gene id: 1434120:MSSIT_RS20370
uniprot id: A0A0E3L9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS15150
gene id: 1434120:MSSIT_RS15150
uniprot id: A0A0E3P6Y1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1434120:MSSIT RS01120
gene id: 1434120:MSSIT_RS01120
uniprot id: A0A0E3L7K3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS15735
gene id: 1434120:MSSIT_RS15735
uniprot id: A0A0E3P749
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434120:MSSIT RS06735
gene id: 1434120:MSSIT_RS06735
uniprot id: A0A0E3L866
names: Similarity
messages: Belongs to the GARS family.

1434120:MSSIT RS20435
gene id: 1434120:MSSIT_RS20435
uniprot id: A0A0E3PBA9
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1434120:MSSIT RS19390
gene id: 1434120:MSSIT_RS19390
uniprot id: A0A0E3P8X1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS02760
gene id: 1434120:MSSIT_RS02760
uniprot id: A0A0E3P1I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS10570
gene id: 1434120:MSSIT_RS10570
uniprot id: A0A0E3L8L0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14145
gene id: 1434120:MSSIT_RS14145
uniprot id: A0A0E3P8R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS15120
gene id: 1434120:MSSIT_RS15120
uniprot id: A0A0E3P6X8
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1434120:MSSIT RS02780
gene id: 1434120:MSSIT_RS02780
uniprot id: A0A0E3P1J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS07975
gene id: 1434120:MSSIT_RS07975
uniprot id: A0A0E3P3H4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434120:MSSIT RS02455
gene id: 1434120:MSSIT_RS02455
uniprot id: A0A0E3P1N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

1434120:MSSIT RS08505
gene id: 1434120:MSSIT_RS08505
uniprot id: A0A0E3P3P5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1434120:MSSIT RS17200
gene id: 1434120:MSSIT_RS17200
uniprot id: A0A0E3PA02
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS00325
gene id: 1434120:MSSIT_RS00325
uniprot id: A0A0E3P2W7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS20305
gene id: 1434120:MSSIT_RS20305
uniprot id: A0A0E3P9A3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434120:MSSIT RS14745
gene id: 1434120:MSSIT_RS14745
uniprot id: A0A0E3P6W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1434120:MSSIT RS15765
gene id: 1434120:MSSIT_RS15765
uniprot id: A0A0E3P753
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS00505
gene id: 1434120:MSSIT_RS00505
uniprot id: A0A0E3P2Y6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1434120:MSSIT RS08235
gene id: 1434120:MSSIT_RS08235
uniprot id: A0A0E3P3Z3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09345
gene id: 1434120:MSSIT_RS09345
uniprot id: A0A0E3P4H6
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS16835
gene id: 1434120:MSSIT_RS16835
uniprot id: A0A0E3L9A0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1434120:MSSIT RS14415
gene id: 1434120:MSSIT_RS14415
uniprot id: A0A0E3L907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS14885
gene id: 1434120:MSSIT_RS14885
uniprot id: A0A0E3P6Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1434120:MSSIT RS19710
gene id: 1434120:MSSIT_RS19710
uniprot id: A0A0E3P902
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434120:MSSIT RS16670
gene id: 1434120:MSSIT_RS16670
uniprot id: A0A0E3P9S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434120:MSSIT RS15095
gene id: 1434120:MSSIT_RS15095
uniprot id: A0A0E3P6V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

1434120:MSSIT RS16570
gene id: 1434120:MSSIT_RS16570
uniprot id: A0A0E3P9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1434120:MSSIT RS18720
gene id: 1434120:MSSIT_RS18720
uniprot id: A0A0E3P8C8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS17060
gene id: 1434120:MSSIT_RS17060
uniprot id: A0A0E3P7Q3
names: Similarity
messages: Belongs to the ZPR1 family.

1434120:MSSIT RS03405
gene id: 1434120:MSSIT_RS03405
uniprot id: A0A0E3P4A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS13870
gene id: 1434120:MSSIT_RS13870
uniprot id: A0A0E3P6C7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00420
gene id: 1434120:MSSIT_RS00420
uniprot id: A0A0E3P0P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434120:MSSIT RS01125
gene id: 1434120:MSSIT_RS01125
uniprot id: A0A0E3P359
names: Similarity
messages: Belongs to the UPF0107 family.

1434120:MSSIT RS01490
gene id: 1434120:MSSIT_RS01490
uniprot id: A0A0E3P0Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434120:MSSIT RS01320
gene id: 1434120:MSSIT_RS01320
uniprot id: A0A0E3L7L1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434120:MSSIT RS03290
gene id: 1434120:MSSIT_RS03290
uniprot id: A0A0E3P207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS17635
gene id: 1434120:MSSIT_RS17635
uniprot id: A0A0E3L9D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1434120:MSSIT RS05255
gene id: 1434120:MSSIT_RS05255
uniprot id: A0A0E3L811
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS20510
gene id: 1434120:MSSIT_RS20510
uniprot id: A0A0E3L9N9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1434120:MSSIT RS05910
gene id: 1434120:MSSIT_RS05910
uniprot id: A0A0E3P2T9
names: Similarity
messages: Belongs to the UPF0047 family.

1434120:MSSIT RS14260
gene id: 1434120:MSSIT_RS14260
uniprot id: A0A0E3P6K5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS04445
gene id: 1434120:MSSIT_RS04445
uniprot id: A0A0E3L7Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS05390
gene id: 1434120:MSSIT_RS05390
uniprot id: A0A0E3P2L0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1434120:MSSIT RS03200
gene id: 1434120:MSSIT_RS03200
uniprot id: A0A0E3P1S3
names: Similarity
messages: Belongs to the MCM family.

1434120:MSSIT RS15145
gene id: 1434120:MSSIT_RS15145
uniprot id: A0A0E3L935
names: Similarity
messages: Belongs to the FBPase class 2 family.

1434120:MSSIT RS19780
gene id: 1434120:MSSIT_RS19780
uniprot id: A0A0E3P910
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1434120:MSSIT RS18365
gene id: 1434120:MSSIT_RS18365
uniprot id: A0A0E3L9F9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1434120:MSSIT RS02790
gene id: 1434120:MSSIT_RS02790
uniprot id: A0A0E3P412
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1434120:MSSIT RS19725
gene id: 1434120:MSSIT_RS19725
uniprot id: A0A0E3PAZ6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14030
gene id: 1434120:MSSIT_RS14030
uniprot id: A0A0E3P6K3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1434120:MSSIT RS10135
gene id: 1434120:MSSIT_RS10135
uniprot id: A0A0E3P4V2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1434120:MSSIT RS06590
gene id: 1434120:MSSIT_RS06590
uniprot id: A0A0E3L862
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1434120:MSSIT RS06210
gene id: 1434120:MSSIT_RS06210
uniprot id: A0A0E3P5G8
names: Similarity
messages: Belongs to the AOR/FOR family.

1434120:MSSIT RS11925
gene id: 1434120:MSSIT_RS11925
uniprot id: A0A0E3L8R1
names: Similarity
messages: Belongs to the LOR family.

1434120:MSSIT RS04530
gene id: 1434120:MSSIT_RS04530
uniprot id: A0A0E3P276
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434120:MSSIT RS18555
gene id: 1434120:MSSIT_RS18555
uniprot id: A0A0E3P8H8
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434120:MSSIT RS18790
gene id: 1434120:MSSIT_RS18790
uniprot id: A0A0E3P8R1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS01780
gene id: 1434120:MSSIT_RS01780
uniprot id: A0A0E3P152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1434120:MSSIT RS04535
gene id: 1434120:MSSIT_RS04535
uniprot id: A0A0E3P4S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1434120:MSSIT RS04380
gene id: 1434120:MSSIT_RS04380
uniprot id: A0A0E3P2A4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS11680
gene id: 1434120:MSSIT_RS11680
uniprot id: A0A0E3P549
names: Similarity
messages: Belongs to the MtxX family.

1434120:MSSIT RS08380
gene id: 1434120:MSSIT_RS08380
uniprot id: A0A0E3P694
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS11085
gene id: 1434120:MSSIT_RS11085
uniprot id: A0A0E3P597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1434120:MSSIT RS14440
gene id: 1434120:MSSIT_RS14440
uniprot id: A0A0E3L908
names: Similarity
messages: Belongs to the DtxR/MntR family.

1434120:MSSIT RS15825
gene id: 1434120:MSSIT_RS15825
uniprot id: A0A0E3P791
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS07890
gene id: 1434120:MSSIT_RS07890
uniprot id: A0A0E3L8B0
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1434120:MSSIT RS13225
gene id: 1434120:MSSIT_RS13225
uniprot id: A0A0E3P649
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05960
gene id: 1434120:MSSIT_RS05960
uniprot id: A0A0E3P2U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS00960
gene id: 1434120:MSSIT_RS00960
uniprot id: A0A0E3P348
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05695
gene id: 1434120:MSSIT_RS05695
uniprot id: A0A0E3P5A5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434120:MSSIT RS14635
gene id: 1434120:MSSIT_RS14635
uniprot id: A0A0E3P6P0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1434120:MSSIT RS06290
gene id: 1434120:MSSIT_RS06290
uniprot id: A0A0E3P375
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1434120:MSSIT RS07535
gene id: 1434120:MSSIT_RS07535
uniprot id: A0A0E3P3V7
names: Similarity
messages: Belongs to the ATPase gamma chain family.

1434120:MSSIT RS04710
gene id: 1434120:MSSIT_RS04710
uniprot id: A0A0E3L7Z1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434120:MSSIT RS07895
gene id: 1434120:MSSIT_RS07895
uniprot id: A0A0E3P3H0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1434120:MSSIT RS16375
gene id: 1434120:MSSIT_RS16375
uniprot id: A0A0E3P9N5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS05750
gene id: 1434120:MSSIT_RS05750
uniprot id: A0A0E3P2R9
names: Similarity
messages: Belongs to the HypE family.

1434120:MSSIT RS01145
gene id: 1434120:MSSIT_RS01145
uniprot id: A0A0E3L7K4
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1434120:MSSIT RS03705
gene id: 1434120:MSSIT_RS03705
uniprot id: A0A0E3P1X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS07920
gene id: 1434120:MSSIT_RS07920
uniprot id: A0A0E3L8B1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1434120:MSSIT RS16870
gene id: 1434120:MSSIT_RS16870
uniprot id: A0A0E3P7R2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1434120:MSSIT RS05200
gene id: 1434120:MSSIT_RS05200
uniprot id: A0A0E3P2U6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS13805
gene id: 1434120:MSSIT_RS13805
uniprot id: A0A0E3L8Y4
names: Similarity
messages: Belongs to the serpin family.

1434120:MSSIT RS11090
gene id: 1434120:MSSIT_RS11090
uniprot id: A0A0E3P4S6
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

1434120:MSSIT RS09510
gene id: 1434120:MSSIT_RS09510
uniprot id: A0A0E3P4N4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1434120:MSSIT RS05720
gene id: 1434120:MSSIT_RS05720
uniprot id: A0A0E3P2R6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434120:MSSIT RS15845
gene id: 1434120:MSSIT_RS15845
uniprot id: A0A0E3P7F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1434120:MSSIT RS08860
gene id: 1434120:MSSIT_RS08860
uniprot id: A0A0E3P4E2
names: Similarity
messages: Belongs to the UPF0212 family.

1434120:MSSIT RS02475
gene id: 1434120:MSSIT_RS02475
uniprot id: A0A0E3P3W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1434120:MSSIT RS03045
gene id: 1434120:MSSIT_RS03045
uniprot id: A0A0E3P1H8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1434120:MSSIT RS07370
gene id: 1434120:MSSIT_RS07370
uniprot id: A0A0E3L889
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS15830
gene id: 1434120:MSSIT_RS15830
uniprot id: A0A0E3P766
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1434120:MSSIT RS08345
gene id: 1434120:MSSIT_RS08345
uniprot id: A0A0E3L8C7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS06025
gene id: 1434120:MSSIT_RS06025
uniprot id: A0A0E3P5E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1434120:MSSIT RS02950
gene id: 1434120:MSSIT_RS02950
uniprot id: A0A0E3P1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1434120:MSSIT RS08040
gene id: 1434120:MSSIT_RS08040
uniprot id: A0A0E3P3H9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1434120:MSSIT RS11480
gene id: 1434120:MSSIT_RS11480
uniprot id: A0A0E3P5E8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1434120:MSSIT RS05965
gene id: 1434120:MSSIT_RS05965
uniprot id: A0A0E3P5D6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS09325
gene id: 1434120:MSSIT_RS09325
uniprot id: A0A0E3P4L4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1434120:MSSIT RS08265
gene id: 1434120:MSSIT_RS08265
uniprot id: A0A0E3L8C4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1434120:MSSIT RS15840
gene id: 1434120:MSSIT_RS15840
uniprot id: A0A0E3P9C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1434120:MSSIT RS15805
gene id: 1434120:MSSIT_RS15805
uniprot id: A0A0E3L962
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1434120:MSSIT RS02030
gene id: 1434120:MSSIT_RS02030
uniprot id: A0A0E3L7N9
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS16025
gene id: 1434120:MSSIT_RS16025
uniprot id: A0A0E3L970
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1434120:MSSIT RS07930
gene id: 1434120:MSSIT_RS07930
uniprot id: A0A0E3P418
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434120:MSSIT RS01235
gene id: 1434120:MSSIT_RS01235
uniprot id: A0A0E3P143
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS06105
gene id: 1434120:MSSIT_RS06105
uniprot id: A0A0E3L845
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS19160
gene id: 1434120:MSSIT_RS19160
uniprot id: A0A0E3P8V2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS06560
gene id: 1434120:MSSIT_RS06560
uniprot id: A0A0E3P3A5
names: Similarity
messages: Belongs to the Nth/MutY family.

1434120:MSSIT RS00625
gene id: 1434120:MSSIT_RS00625
uniprot id: A0A0E3L7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1434120:MSSIT RS13560
gene id: 1434120:MSSIT_RS13560
uniprot id: A0A0E3P677
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434120:MSSIT RS01575
gene id: 1434120:MSSIT_RS01575
uniprot id: A0A0E3L7M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1434120:MSSIT RS03970
gene id: 1434120:MSSIT_RS03970
uniprot id: A0A0E3P228
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05025
gene id: 1434120:MSSIT_RS05025
uniprot id: A0A0E3P2J2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1434120:MSSIT RS20630
gene id: 1434120:MSSIT_RS20630
uniprot id: A0A0E3P9C9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1434120:MSSIT RS12565
gene id: 1434120:MSSIT_RS12565
uniprot id: A0A0E3P5K8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434120:MSSIT RS18650
gene id: 1434120:MSSIT_RS18650
uniprot id: A0A0E3L9G9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1434120:MSSIT RS09425
gene id: 1434120:MSSIT_RS09425
uniprot id: A0A0E3P4M6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00630
gene id: 1434120:MSSIT_RS00630
uniprot id: A0A0E3P0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1434120:MSSIT RS18005
gene id: 1434120:MSSIT_RS18005
uniprot id: A0A0E3P8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1434120:MSSIT RS17165
gene id: 1434120:MSSIT_RS17165
uniprot id: A0A0E3P7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17420
gene id: 1434120:MSSIT_RS17420
uniprot id: A0A0E3P838
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS07665
gene id: 1434120:MSSIT_RS07665
uniprot id: A0A0E3P3X8
names: Similarity
messages: Belongs to the UPF0145 family.

1434120:MSSIT RS01015
gene id: 1434120:MSSIT_RS01015
uniprot id: A0A0E3P0Z8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1434120:MSSIT RS20955
gene id: 1434120:MSSIT_RS20955
uniprot id: A0A0E3L9Q6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434120:MSSIT RS20315
gene id: 1434120:MSSIT_RS20315
uniprot id: A0A0E3PB89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434120:MSSIT RS03870
gene id: 1434120:MSSIT_RS03870
uniprot id: A0A0E3P218
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1434120:MSSIT RS00635
gene id: 1434120:MSSIT_RS00635
uniprot id: A0A0E3P306
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1434120:MSSIT RS11865
gene id: 1434120:MSSIT_RS11865
uniprot id: A0A0E3P585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434120:MSSIT RS14935
gene id: 1434120:MSSIT_RS14935
uniprot id: A0A0E3P6U9
names: Similarity
messages: Belongs to the UPF0210 family.

1434120:MSSIT RS09270
gene id: 1434120:MSSIT_RS09270
uniprot id: A0A0E3P3Y8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1434120:MSSIT RS12445
gene id: 1434120:MSSIT_RS12445
uniprot id: A0A0E3P5T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1434120:MSSIT RS18180
gene id: 1434120:MSSIT_RS18180
uniprot id: A0A0E3P866
names: Similarity
messages: Belongs to the HdrC family.

1434120:MSSIT RS16070
gene id: 1434120:MSSIT_RS16070
uniprot id: A0A0E3P797
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

1434120:MSSIT RS01195
gene id: 1434120:MSSIT_RS01195
uniprot id: A0A0E3P100
names: Subunit
messages: Homotetramer.

1434120:MSSIT RS16995
gene id: 1434120:MSSIT_RS16995
uniprot id: A0A0E3P9X4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1434120:MSSIT RS17540
gene id: 1434120:MSSIT_RS17540
uniprot id: A0A0E3PA52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1434120:MSSIT RS15085
gene id: 1434120:MSSIT_RS15085
uniprot id: A0A0E3P6X0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1434120:MSSIT RS19385
gene id: 1434120:MSSIT_RS19385
uniprot id: A0A0E3PAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434120:MSSIT RS09595
gene id: 1434120:MSSIT_RS09595
uniprot id: A0A0E3P4L2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS04770
gene id: 1434120:MSSIT_RS04770
uniprot id: A0A0E3P4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS07835
gene id: 1434120:MSSIT_RS07835
uniprot id: A0A0E3P3T1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1434120:MSSIT RS15310
gene id: 1434120:MSSIT_RS15310
uniprot id: A0A0E3P6Y9
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

1434120:MSSIT RS17625
gene id: 1434120:MSSIT_RS17625
uniprot id: A0A0E3P7Y0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1434120:MSSIT RS15250
gene id: 1434120:MSSIT_RS15250
uniprot id: A0A0E3P6X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434120:MSSIT RS17860
gene id: 1434120:MSSIT_RS17860
uniprot id: A0A0E3PA87
names: Similarity
messages: Belongs to the peptidase S49 family.

1434120:MSSIT RS14730
gene id: 1434120:MSSIT_RS14730
uniprot id: A0A0E3L919
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS15785
gene id: 1434120:MSSIT_RS15785
uniprot id: A0A0E3P772
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS15800
gene id: 1434120:MSSIT_RS15800
uniprot id: A0A0E3P9B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS09505
gene id: 1434120:MSSIT_RS09505
uniprot id: A0A0E3L8H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434120:MSSIT RS17640
gene id: 1434120:MSSIT_RS17640
uniprot id: A0A0E3P876
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434120:MSSIT RS01280
gene id: 1434120:MSSIT_RS01280
uniprot id: A0A0E3P3A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS18675
gene id: 1434120:MSSIT_RS18675
uniprot id: A0A0E3L9H0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1434120:MSSIT RS00330
gene id: 1434120:MSSIT_RS00330
uniprot id: A0A0E3P0M2
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1434120:MSSIT RS19345
gene id: 1434120:MSSIT_RS19345
uniprot id: A0A0E3L9J4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS01020
gene id: 1434120:MSSIT_RS01020
uniprot id: A0A0E3P0P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1434120:MSSIT RS08435
gene id: 1434120:MSSIT_RS08435
uniprot id: A0A0E3L8D0
names: Similarity
messages: Belongs to the HsdR family.

1434120:MSSIT RS10040
gene id: 1434120:MSSIT_RS10040
uniprot id: A0A0E3L8J1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS08990
gene id: 1434120:MSSIT_RS08990
uniprot id: A0A0E3L8F1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03715
gene id: 1434120:MSSIT_RS03715
uniprot id: A0A0E3P4F8
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS13290
gene id: 1434120:MSSIT_RS13290
uniprot id: A0A0E3P650
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1434120:MSSIT RS15470
gene id: 1434120:MSSIT_RS15470
uniprot id: A0A0E3P7A8
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS15775
gene id: 1434120:MSSIT_RS15775
uniprot id: A0A0E3P7F0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1434120:MSSIT RS02770
gene id: 1434120:MSSIT_RS02770
uniprot id: A0A0E3P1R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS13350
gene id: 1434120:MSSIT_RS13350
uniprot id: A0A0E3P663
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1434120:MSSIT RS01225
gene id: 1434120:MSSIT_RS01225
uniprot id: A0A0E3L7K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS04485
gene id: 1434120:MSSIT_RS04485
uniprot id: A0A0E3P2B2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1434120:MSSIT RS17935
gene id: 1434120:MSSIT_RS17935
uniprot id: A0A0E3P8D1
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

1434120:MSSIT RS20455
gene id: 1434120:MSSIT_RS20455
uniprot id: A0A0E3P9D0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434120:MSSIT RS13525
gene id: 1434120:MSSIT_RS13525
uniprot id: A0A0E3P673
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1434120:MSSIT RS16935
gene id: 1434120:MSSIT_RS16935
uniprot id: A0A0E3L9A4
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS11700
gene id: 1434120:MSSIT_RS11700
uniprot id: A0A0E3P5H2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS04455
gene id: 1434120:MSSIT_RS04455
uniprot id: A0A0E3P2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1434120:MSSIT RS00265
gene id: 1434120:MSSIT_RS00265
uniprot id: A0A0E3L7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS01685
gene id: 1434120:MSSIT_RS01685
uniprot id: A0A0E3P0Y3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1434120:MSSIT RS10980
gene id: 1434120:MSSIT_RS10980
uniprot id: A0A0E3P7E5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12490
gene id: 1434120:MSSIT_RS12490
uniprot id: A0A0E3P5J6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434120:MSSIT RS09250
gene id: 1434120:MSSIT_RS09250
uniprot id: A0A0E3P6M4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1434120:MSSIT RS10475
gene id: 1434120:MSSIT_RS10475
uniprot id: A0A0E3P4K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1434120:MSSIT RS16730
gene id: 1434120:MSSIT_RS16730
uniprot id: A0A0E3P9T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1434120:MSSIT RS16075
gene id: 1434120:MSSIT_RS16075
uniprot id: A0A0E3P9F9
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

1434120:MSSIT RS04340
gene id: 1434120:MSSIT_RS04340
uniprot id: A0A0E3P4P4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS04390
gene id: 1434120:MSSIT_RS04390
uniprot id: A0A0E3P297
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1434120:MSSIT RS16220
gene id: 1434120:MSSIT_RS16220
uniprot id: A0A0E3P7C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434120:MSSIT RS16580
gene id: 1434120:MSSIT_RS16580
uniprot id: A0A0E3L991
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1434120:MSSIT RS08230
gene id: 1434120:MSSIT_RS08230
uniprot id: A0A0E3P3K4
names: Function
messages: Part of a potassium transport system.

1434120:MSSIT RS13075
gene id: 1434120:MSSIT_RS13075
uniprot id: A0A0E3L8V5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14375
gene id: 1434120:MSSIT_RS14375
uniprot id: A0A0E3P6J8
names: Similarity
messages: Belongs to the TPP enzyme family.

1434120:MSSIT RS08790
gene id: 1434120:MSSIT_RS08790
uniprot id: A0A0E3L8E3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS18670
gene id: 1434120:MSSIT_RS18670
uniprot id: A0A0E3P8I8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1434120:MSSIT RS05905
gene id: 1434120:MSSIT_RS05905
uniprot id: A0A0E3P2X7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434120:MSSIT RS13230
gene id: 1434120:MSSIT_RS13230
uniprot id: A0A0E3P635
names: Similarity
messages: Belongs to the TlyA family.

1434120:MSSIT RS08700
gene id: 1434120:MSSIT_RS08700
uniprot id: A0A0E3P475
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1434120:MSSIT RS04035
gene id: 1434120:MSSIT_RS04035
uniprot id: A0A0E3P243
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS13240
gene id: 1434120:MSSIT_RS13240
uniprot id: A0A0E3P8E1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS18320
gene id: 1434120:MSSIT_RS18320
uniprot id: A0A0E3P8E6
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS17900
gene id: 1434120:MSSIT_RS17900
uniprot id: A0A0E3P8C3
names: Similarity
messages: Belongs to the SUI1 family.

1434120:MSSIT RS08845
gene id: 1434120:MSSIT_RS08845
uniprot id: A0A0E3P6G1
names: Similarity
messages: Belongs to the glutaredoxin family.

1434120:MSSIT RS08875
gene id: 1434120:MSSIT_RS08875
uniprot id: A0A0E3P6G2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1434120:MSSIT RS08140
gene id: 1434120:MSSIT_RS08140
uniprot id: A0A0E3L8B9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS17130
gene id: 1434120:MSSIT_RS17130
uniprot id: A0A0E3P7T3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434120:MSSIT RS11960
gene id: 1434120:MSSIT_RS11960
uniprot id: A0A0E3P5A9
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

1434120:MSSIT RS07445
gene id: 1434120:MSSIT_RS07445
uniprot id: A0A0E3P3L7
names: Similarity
messages: Belongs to the CutA family.

1434120:MSSIT RS16320
gene id: 1434120:MSSIT_RS16320
uniprot id: A0A0E3L981
names: Similarity
messages: Belongs to the UPF0179 family.

1434120:MSSIT RS11295
gene id: 1434120:MSSIT_RS11295
uniprot id: A0A0E3P4X2
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05180
gene id: 1434120:MSSIT_RS05180
uniprot id: A0A0E3L808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1434120:MSSIT RS04970
gene id: 1434120:MSSIT_RS04970
uniprot id: A0A0E3P2I9
names: Similarity
messages: Belongs to the HsdR family.

1434120:MSSIT RS01795
gene id: 1434120:MSSIT_RS01795
uniprot id: A0A0E3P3J7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1434120:MSSIT RS07230
gene id: 1434120:MSSIT_RS07230
uniprot id: A0A0E3P3Q4
names: Similarity
messages: Belongs to the class-I fumarase family.

1434120:MSSIT RS21465
gene id: 1434120:MSSIT_RS21465
uniprot id: A0A0E3PAN1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS20625
gene id: 1434120:MSSIT_RS20625
uniprot id: A0A0E3P9H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

1434120:MSSIT RS13685
gene id: 1434120:MSSIT_RS13685
uniprot id: A0A0E3P6A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434120:MSSIT RS04130
gene id: 1434120:MSSIT_RS04130
uniprot id: A0A0E3L7W9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17295
gene id: 1434120:MSSIT_RS17295
uniprot id: A0A0E3PA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS08395
gene id: 1434120:MSSIT_RS08395
uniprot id: A0A0E3P477
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS18375
gene id: 1434120:MSSIT_RS18375
uniprot id: A0A0E3PAD4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS00840
gene id: 1434120:MSSIT_RS00840
uniprot id: A0A0E3L7J2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434120:MSSIT RS21095
gene id: 1434120:MSSIT_RS21095
uniprot id: A0A0E3P2E5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434120:MSSIT RS17710
gene id: 1434120:MSSIT_RS17710
uniprot id: A0A0E3P809
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS13425
gene id: 1434120:MSSIT_RS13425
uniprot id: A0A0E3L8W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434120:MSSIT RS12720
gene id: 1434120:MSSIT_RS12720
uniprot id: A0A0E3P5M9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS18330
gene id: 1434120:MSSIT_RS18330
uniprot id: A0A0E3P893
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS18775
gene id: 1434120:MSSIT_RS18775
uniprot id: A0A0E3L9H4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1434120:MSSIT RS19085
gene id: 1434120:MSSIT_RS19085
uniprot id: A0A0E3P8P9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS01205
gene id: 1434120:MSSIT_RS01205
uniprot id: A0A0E3P139
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1434120:MSSIT RS07040
gene id: 1434120:MSSIT_RS07040
uniprot id: A0A0E3P3A3
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1434120:MSSIT RS05385
gene id: 1434120:MSSIT_RS05385
uniprot id: A0A0E3P2P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1434120:MSSIT RS01090
gene id: 1434120:MSSIT_RS01090
uniprot id: A0A0E3P355
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS00250
gene id: 1434120:MSSIT_RS00250
uniprot id: A0A0E3P0E8
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

1434120:MSSIT RS19875
gene id: 1434120:MSSIT_RS19875
uniprot id: A0A0E3P922
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

1434120:MSSIT RS14775
gene id: 1434120:MSSIT_RS14775
uniprot id: A0A0E3P8Y0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00215
gene id: 1434120:MSSIT_RS00215
uniprot id: A0A0E3P0M1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434120:MSSIT RS18325
gene id: 1434120:MSSIT_RS18325
uniprot id: A0A0E3P8B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS20765
gene id: 1434120:MSSIT_RS20765
uniprot id: A0A0E3P9I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1434120:MSSIT RS16415
gene id: 1434120:MSSIT_RS16415
uniprot id: A0A0E3P9P0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1434120:MSSIT RS14250
gene id: 1434120:MSSIT_RS14250
uniprot id: A0A0E3P6P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1434120:MSSIT RS18530
gene id: 1434120:MSSIT_RS18530
uniprot id: A0A0E3P8B2
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1434120:MSSIT RS04185
gene id: 1434120:MSSIT_RS04185
uniprot id: A0A0E3P2E3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS08650
gene id: 1434120:MSSIT_RS08650
uniprot id: A0A0E3L8D8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS11025
gene id: 1434120:MSSIT_RS11025
uniprot id: A0A0E3P592
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434120:MSSIT RS01220
gene id: 1434120:MSSIT_RS01220
uniprot id: A0A0E3P384
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS17645
gene id: 1434120:MSSIT_RS17645
uniprot id: A0A0E3P837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434120:MSSIT RS02940
gene id: 1434120:MSSIT_RS02940
uniprot id: A0A0E3P1K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1434120:MSSIT RS02665
gene id: 1434120:MSSIT_RS02665
uniprot id: A0A0E3P1G4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1434120:MSSIT RS19565
gene id: 1434120:MSSIT_RS19565
uniprot id: A0A0E3L9K2
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS04195
gene id: 1434120:MSSIT_RS04195
uniprot id: A0A0E3P233
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS19035
gene id: 1434120:MSSIT_RS19035
uniprot id: A0A0E3L9I3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1434120:MSSIT RS06205
gene id: 1434120:MSSIT_RS06205
uniprot id: A0A0E3L848
names: Similarity
messages: Belongs to the UPF0280 family.

1434120:MSSIT RS01945
gene id: 1434120:MSSIT_RS01945
uniprot id: A0A0E3P3M7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS07940
gene id: 1434120:MSSIT_RS07940
uniprot id: A0A0E3P3H3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

1434120:MSSIT RS01255
gene id: 1434120:MSSIT_RS01255
uniprot id: A0A0E3P390
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS09585
gene id: 1434120:MSSIT_RS09585
uniprot id: A0A0E3P4I3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1434120:MSSIT RS05520
gene id: 1434120:MSSIT_RS05520
uniprot id: A0A0E3P2R8
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434120:MSSIT RS02875
gene id: 1434120:MSSIT_RS02875
uniprot id: A0A0E3P1S5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS06820
gene id: 1434120:MSSIT_RS06820
uniprot id: A0A0E3L868
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

1434120:MSSIT RS08330
gene id: 1434120:MSSIT_RS08330
uniprot id: A0A0E3P3M6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14215
gene id: 1434120:MSSIT_RS14215
uniprot id: A0A0E3P6P4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1434120:MSSIT RS00835
gene id: 1434120:MSSIT_RS00835
uniprot id: A0A0E3P333
names: Similarity
messages: Belongs to the UPF0677 family.

1434120:MSSIT RS01140
gene id: 1434120:MSSIT_RS01140
uniprot id: A0A0E3P0R7
names: Similarity
messages: Belongs to the citrate synthase family.

1434120:MSSIT RS02675
gene id: 1434120:MSSIT_RS02675
uniprot id: A0A0E3P1H7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1434120:MSSIT RS20730
gene id: 1434120:MSSIT_RS20730
uniprot id: A0A0E3P9E2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1434120:MSSIT RS05995
gene id: 1434120:MSSIT_RS05995
uniprot id: A0A0E3P5E0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS08705
gene id: 1434120:MSSIT_RS08705
uniprot id: A0A0E3P4B2
names: Similarity
messages: Belongs to the TrpF family.

1434120:MSSIT RS02440
gene id: 1434120:MSSIT_RS02440
uniprot id: A0A0E3P1A2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS03115
gene id: 1434120:MSSIT_RS03115
uniprot id: A0A0E3P1J4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434120:MSSIT RS07080
gene id: 1434120:MSSIT_RS07080
uniprot id: A0A0E3P3F6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1434120:MSSIT RS08850
gene id: 1434120:MSSIT_RS08850
uniprot id: A0A0E3P491
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1434120:MSSIT RS05215
gene id: 1434120:MSSIT_RS05215
uniprot id: A0A0E3P547
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1434120:MSSIT RS01630
gene id: 1434120:MSSIT_RS01630
uniprot id: A0A0E3P138
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1434120:MSSIT RS01025
gene id: 1434120:MSSIT_RS01025
uniprot id: A0A0E3L7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1434120:MSSIT RS13620
gene id: 1434120:MSSIT_RS13620
uniprot id: A0A0E3P8K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

1434120:MSSIT RS20235
gene id: 1434120:MSSIT_RS20235
uniprot id: A0A0E3P954
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS16610
gene id: 1434120:MSSIT_RS16610
uniprot id: A0A0E3P9R7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1434120:MSSIT RS03450
gene id: 1434120:MSSIT_RS03450
uniprot id: A0A0E3P229
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

1434120:MSSIT RS16185
gene id: 1434120:MSSIT_RS16185
uniprot id: A0A0E3P9H7
names: Similarity
messages: Belongs to the UPF0677 family.

1434120:MSSIT RS16650
gene id: 1434120:MSSIT_RS16650
uniprot id: A0A0E3P7N1
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1434120:MSSIT RS13305
gene id: 1434120:MSSIT_RS13305
uniprot id: A0A0E3P8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1434120:MSSIT RS20905
gene id: 1434120:MSSIT_RS20905
uniprot id: A0A0E3L9Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1434120:MSSIT RS02690
gene id: 1434120:MSSIT_RS02690
uniprot id: A0A0E3P3Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1434120:MSSIT RS00950
gene id: 1434120:MSSIT_RS00950
uniprot id: A0A0E3P0N5
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1434120:MSSIT RS10785
gene id: 1434120:MSSIT_RS10785
uniprot id: A0A0E3P4P7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS19155
gene id: 1434120:MSSIT_RS19155
uniprot id: A0A0E3L9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1434120:MSSIT RS07795
gene id: 1434120:MSSIT_RS07795
uniprot id: A0A0E3P3S3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS18010
gene id: 1434120:MSSIT_RS18010
uniprot id: A0A0E3L9E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1434120:MSSIT RS10530
gene id: 1434120:MSSIT_RS10530
uniprot id: A0A0E3P532
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS20155
gene id: 1434120:MSSIT_RS20155
uniprot id: A0A0E3PB63
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434120:MSSIT RS05250
gene id: 1434120:MSSIT_RS05250
uniprot id: A0A0E3P2M5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03445
gene id: 1434120:MSSIT_RS03445
uniprot id: A0A0E3P1U3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1434120:MSSIT RS02510
gene id: 1434120:MSSIT_RS02510
uniprot id: A0A0E3L7Q7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS16940
gene id: 1434120:MSSIT_RS16940
uniprot id: A0A0E3P7P0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434120:MSSIT RS08615
gene id: 1434120:MSSIT_RS08615
uniprot id: A0A0E3P451
names: Similarity
messages: Belongs to the AOR/FOR family.

1434120:MSSIT RS15135
gene id: 1434120:MSSIT_RS15135
uniprot id: A0A0E3P741
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1434120:MSSIT RS02145
gene id: 1434120:MSSIT_RS02145
uniprot id: A0A0E3P1B2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1434120:MSSIT RS03515
gene id: 1434120:MSSIT_RS03515
uniprot id: A0A0E3L7U5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1434120:MSSIT RS00175
gene id: 1434120:MSSIT_RS00175
uniprot id: A0A0E3P2V1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1434120:MSSIT RS19075
gene id: 1434120:MSSIT_RS19075
uniprot id: A0A0E3PAL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS01495
gene id: 1434120:MSSIT_RS01495
uniprot id: A0A0E3P0W1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS07530
gene id: 1434120:MSSIT_RS07530
uniprot id: A0A0E3P3P8
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

1434120:MSSIT RS10170
gene id: 1434120:MSSIT_RS10170
uniprot id: A0A0E3L8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS12740
gene id: 1434120:MSSIT_RS12740
uniprot id: A0A0E3P5X3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS19180
gene id: 1434120:MSSIT_RS19180
uniprot id: A0A0E3L9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS12040
gene id: 1434120:MSSIT_RS12040
uniprot id: A0A0E3L8R6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1434120:MSSIT RS13535
gene id: 1434120:MSSIT_RS13535
uniprot id: A0A0E3P8I9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1434120:MSSIT RS17170
gene id: 1434120:MSSIT_RS17170
uniprot id: A0A0E3L9B3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS15240
gene id: 1434120:MSSIT_RS15240
uniprot id: A0A0E3P6Z5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05580
gene id: 1434120:MSSIT_RS05580
uniprot id: A0A0E3P2S9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1434120:MSSIT RS05790
gene id: 1434120:MSSIT_RS05790
uniprot id: A0A0E3P2V9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS08055
gene id: 1434120:MSSIT_RS08055
uniprot id: A0A0E3P3Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1434120:MSSIT RS18105
gene id: 1434120:MSSIT_RS18105
uniprot id: A0A0E3P8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS02960
gene id: 1434120:MSSIT_RS02960
uniprot id: A0A0E3L7S3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS03020
gene id: 1434120:MSSIT_RS03020
uniprot id: A0A0E3P1H4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS02725
gene id: 1434120:MSSIT_RS02725
uniprot id: A0A0E3P1H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1434120:MSSIT RS15350
gene id: 1434120:MSSIT_RS15350
uniprot id: A0A0E3P782
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS10745
gene id: 1434120:MSSIT_RS10745
uniprot id: A0A0E3P554
names: Similarity
messages: Belongs to the UPF0282 family.

1434120:MSSIT RS04565
gene id: 1434120:MSSIT_RS04565
uniprot id: A0A0E3P284
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1434120:MSSIT RS11845
gene id: 1434120:MSSIT_RS11845
uniprot id: A0A0E3L8Q8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434120:MSSIT RS00500
gene id: 1434120:MSSIT_RS00500
uniprot id: A0A0E3P0H0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17135
gene id: 1434120:MSSIT_RS17135
uniprot id: A0A0E3P7R5
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS01385
gene id: 1434120:MSSIT_RS01385
uniprot id: A0A0E3P0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS04740
gene id: 1434120:MSSIT_RS04740
uniprot id: A0A0E3L7Z2
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS02735
gene id: 1434120:MSSIT_RS02735
uniprot id: A0A0E3L7R5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS07660
gene id: 1434120:MSSIT_RS07660
uniprot id: A0A0E3P3R6
names: Similarity
messages: Belongs to the glutamine synthetase family.

1434120:MSSIT RS08865
gene id: 1434120:MSSIT_RS08865
uniprot id: A0A0E3P3T8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1434120:MSSIT RS17490
gene id: 1434120:MSSIT_RS17490
uniprot id: A0A0E3P817
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS11690
gene id: 1434120:MSSIT_RS11690
uniprot id: A0A0E3P7M8
names: Similarity
messages: Belongs to the MtrH family.

1434120:MSSIT RS09755
gene id: 1434120:MSSIT_RS09755
uniprot id: A0A0E3P4L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434120:MSSIT RS14550
gene id: 1434120:MSSIT_RS14550
uniprot id: A0A0E3P6S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434120:MSSIT RS01755
gene id: 1434120:MSSIT_RS01755
uniprot id: A0A0E3P3J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS04310
gene id: 1434120:MSSIT_RS04310
uniprot id: A0A0E3P4P3
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434120:MSSIT RS02000
gene id: 1434120:MSSIT_RS02000
uniprot id: A0A0E3P192
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS08715
gene id: 1434120:MSSIT_RS08715
uniprot id: A0A0E3P3R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1434120:MSSIT RS16370
gene id: 1434120:MSSIT_RS16370
uniprot id: A0A0E3L983
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1434120:MSSIT RS02765
gene id: 1434120:MSSIT_RS02765
uniprot id: A0A0E3L7R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1434120:MSSIT RS16095
gene id: 1434120:MSSIT_RS16095
uniprot id: A0A0E3P7D0
names: Similarity
messages: Belongs to the Fur family.

1434120:MSSIT RS06300
gene id: 1434120:MSSIT_RS06300
uniprot id: A0A0E3P304
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS10370
gene id: 1434120:MSSIT_RS10370
uniprot id: A0A0E3P4J8
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS08940
gene id: 1434120:MSSIT_RS08940
uniprot id: A0A0E3P498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1434120:MSSIT RS16735
gene id: 1434120:MSSIT_RS16735
uniprot id: A0A0E3L997
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1434120:MSSIT RS14540
gene id: 1434120:MSSIT_RS14540
uniprot id: A0A0E3L912
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434120:MSSIT RS15780
gene id: 1434120:MSSIT_RS15780
uniprot id: A0A0E3L961
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS10685
gene id: 1434120:MSSIT_RS10685
uniprot id: A0A0E3P4N8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1434120:MSSIT RS20975
gene id: 1434120:MSSIT_RS20975
uniprot id: A0A0E3PBJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434120:MSSIT RS17150
gene id: 1434120:MSSIT_RS17150
uniprot id: A0A0E3P7Z5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434120:MSSIT RS19090
gene id: 1434120:MSSIT_RS19090
uniprot id: A0A0E3L9I5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS19605
gene id: 1434120:MSSIT_RS19605
uniprot id: A0A0E3P8V6
names: Similarity
messages: Belongs to the thymidylate kinase family.

1434120:MSSIT RS19165
gene id: 1434120:MSSIT_RS19165
uniprot id: A0A0E3P8Q8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS09580
gene id: 1434120:MSSIT_RS09580
uniprot id: A0A0E3L8H4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS17665
gene id: 1434120:MSSIT_RS17665
uniprot id: A0A0E3P882
names: Similarity
messages: Belongs to the PurH family.

1434120:MSSIT RS17595
gene id: 1434120:MSSIT_RS17595
uniprot id: A0A0E3P7X6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS02650
gene id: 1434120:MSSIT_RS02650
uniprot id: A0A0E3P1C6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1434120:MSSIT RS01075
gene id: 1434120:MSSIT_RS01075
uniprot id: A0A0E3P109
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14830
gene id: 1434120:MSSIT_RS14830
uniprot id: A0A0E3P6S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

1434120:MSSIT RS20175
gene id: 1434120:MSSIT_RS20175
uniprot id: A0A0E3P973
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS05975
gene id: 1434120:MSSIT_RS05975
uniprot id: A0A0E3P352
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS18050
gene id: 1434120:MSSIT_RS18050
uniprot id: A0A0E3P871
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434120:MSSIT RS20760
gene id: 1434120:MSSIT_RS20760
uniprot id: A0A0E3P9J0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1434120:MSSIT RS20095
gene id: 1434120:MSSIT_RS20095
uniprot id: A0A0E3P928
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1434120:MSSIT RS15725
gene id: 1434120:MSSIT_RS15725
uniprot id: A0A0E3P775
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

1434120:MSSIT RS06595
gene id: 1434120:MSSIT_RS06595
uniprot id: A0A0E3P3B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434120:MSSIT RS17535
gene id: 1434120:MSSIT_RS17535
uniprot id: A0A0E3L9C8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1434120:MSSIT RS07235
gene id: 1434120:MSSIT_RS07235
uniprot id: A0A0E3P3B2
names: Similarity
messages: Belongs to the class-I fumarase family.

1434120:MSSIT RS09525
gene id: 1434120:MSSIT_RS09525
uniprot id: A0A0E3P6S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

1434120:MSSIT RS14120
gene id: 1434120:MSSIT_RS14120
uniprot id: A0A0E3P6L8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1434120:MSSIT RS04175
gene id: 1434120:MSSIT_RS04175
uniprot id: A0A0E3P275
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1434120:MSSIT RS15755
gene id: 1434120:MSSIT_RS15755
uniprot id: A0A0E3L960
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1434120:MSSIT RS05860
gene id: 1434120:MSSIT_RS05860
uniprot id: A0A0E3P343
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS02720
gene id: 1434120:MSSIT_RS02720
uniprot id: A0A0E3P403
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1434120:MSSIT RS05130
gene id: 1434120:MSSIT_RS05130
uniprot id: A0A0E3L806
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS17285
gene id: 1434120:MSSIT_RS17285
uniprot id: A0A0E3P7T9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS16705
gene id: 1434120:MSSIT_RS16705
uniprot id: A0A0E3P7T0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12615
gene id: 1434120:MSSIT_RS12615
uniprot id: A0A0E3P5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1434120:MSSIT RS11000
gene id: 1434120:MSSIT_RS11000
uniprot id: A0A0E3L8M5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17240
gene id: 1434120:MSSIT_RS17240
uniprot id: A0A0E3L9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17670
gene id: 1434120:MSSIT_RS17670
uniprot id: A0A0E3P841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434120:MSSIT RS20895
gene id: 1434120:MSSIT_RS20895
uniprot id: A0A0E3P9K7
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1434120:MSSIT RS18770
gene id: 1434120:MSSIT_RS18770
uniprot id: A0A0E3P8H2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1434120:MSSIT RS14495
gene id: 1434120:MSSIT_RS14495
uniprot id: A0A0E3P6N3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12435
gene id: 1434120:MSSIT_RS12435
uniprot id: A0A0E3P5S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1434120:MSSIT RS05770
gene id: 1434120:MSSIT_RS05770
uniprot id: A0A0E3P328
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1434120:MSSIT RS04715
gene id: 1434120:MSSIT_RS04715
uniprot id: A0A0E3P2M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434120:MSSIT RS19025
gene id: 1434120:MSSIT_RS19025
uniprot id: A0A0E3P8L0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00985
gene id: 1434120:MSSIT_RS00985
uniprot id: A0A0E3P0N8
names: Similarity
messages: Belongs to the peptidase M24B family.

1434120:MSSIT RS11280
gene id: 1434120:MSSIT_RS11280
uniprot id: A0A0E3L8N6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1434120:MSSIT RS02825
gene id: 1434120:MSSIT_RS02825
uniprot id: A0A0E3L7R8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1434120:MSSIT RS20440
gene id: 1434120:MSSIT_RS20440
uniprot id: A0A0E3P9E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1434120:MSSIT RS11770
gene id: 1434120:MSSIT_RS11770
uniprot id: A0A0E3P5I4
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

1434120:MSSIT RS00935
gene id: 1434120:MSSIT_RS00935
uniprot id: A0A0E3P0V5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05160
gene id: 1434120:MSSIT_RS05160
uniprot id: A0A0E3P2L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1434120:MSSIT RS06305
gene id: 1434120:MSSIT_RS06305
uniprot id: A0A0E3P5I6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1434120:MSSIT RS20295
gene id: 1434120:MSSIT_RS20295
uniprot id: A0A0E3P967
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

1434120:MSSIT RS03410
gene id: 1434120:MSSIT_RS03410
uniprot id: A0A0E3P1T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1434120:MSSIT RS01905
gene id: 1434120:MSSIT_RS01905
uniprot id: A0A0E3L7N4
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1434120:MSSIT RS14720
gene id: 1434120:MSSIT_RS14720
uniprot id: A0A0E3P6R4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1434120:MSSIT RS08035
gene id: 1434120:MSSIT_RS08035
uniprot id: A0A0E3L8B5
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudC subfamily.

1434120:MSSIT RS09590
gene id: 1434120:MSSIT_RS09590
uniprot id: A0A0E3P6T5
names: Similarity
messages: Belongs to the DMRL synthase family.

1434120:MSSIT RS05230
gene id: 1434120:MSSIT_RS05230
uniprot id: A0A0E3L810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS09935
gene id: 1434120:MSSIT_RS09935
uniprot id: A0A0E3P4D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1434120:MSSIT RS20745
gene id: 1434120:MSSIT_RS20745
uniprot id: A0A0E3P9C2
names: Function
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1434120:MSSIT RS10650
gene id: 1434120:MSSIT_RS10650
uniprot id: A0A0E3P4Y8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1434120:MSSIT RS04190
gene id: 1434120:MSSIT_RS04190
uniprot id: A0A0E3P269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1434120:MSSIT RS00620
gene id: 1434120:MSSIT_RS00620
uniprot id: A0A0E3P0I1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1434120:MSSIT RS08215
gene id: 1434120:MSSIT_RS08215
uniprot id: A0A0E3P3Y7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1434120:MSSIT RS07680
gene id: 1434120:MSSIT_RS07680
uniprot id: A0A0E3P609
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1434120:MSSIT RS18175
gene id: 1434120:MSSIT_RS18175
uniprot id: A0A0E3P897
names: Similarity
messages: Belongs to the HdrB family.

1434120:MSSIT RS16360
gene id: 1434120:MSSIT_RS16360
uniprot id: A0A0E3P7H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1434120:MSSIT RS03375
gene id: 1434120:MSSIT_RS03375
uniprot id: A0A0E3P4A5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

1434120:MSSIT RS04985
gene id: 1434120:MSSIT_RS04985
uniprot id: A0A0E3P2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1434120:MSSIT RS05665
gene id: 1434120:MSSIT_RS05665
uniprot id: A0A0E3L827
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09785
gene id: 1434120:MSSIT_RS09785
uniprot id: A0A0E3P4M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434120:MSSIT RS16465
gene id: 1434120:MSSIT_RS16465
uniprot id: A0A0E3P7I5
names: Similarity
messages: Belongs to the NAD synthetase family.

1434120:MSSIT RS10015
gene id: 1434120:MSSIT_RS10015
uniprot id: A0A0E3P4E1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS16860
gene id: 1434120:MSSIT_RS16860
uniprot id: A0A0E3P7U9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05150
gene id: 1434120:MSSIT_RS05150
uniprot id: A0A0E3P530
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS03860
gene id: 1434120:MSSIT_RS03860
uniprot id: A0A0E3P214
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1434120:MSSIT RS12610
gene id: 1434120:MSSIT_RS12610
uniprot id: A0A0E3P5W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1434120:MSSIT RS15225
gene id: 1434120:MSSIT_RS15225
uniprot id: A0A0E3P942
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS01540
gene id: 1434120:MSSIT_RS01540
uniprot id: A0A0E3P128
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS08080
gene id: 1434120:MSSIT_RS08080
uniprot id: A0A0E3P655
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS20400
gene id: 1434120:MSSIT_RS20400
uniprot id: A0A0E3P975
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1434120:MSSIT RS13565
gene id: 1434120:MSSIT_RS13565
uniprot id: A0A0E3P8J3
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

1434120:MSSIT RS20950
gene id: 1434120:MSSIT_RS20950
uniprot id: A0A0E3P9L7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434120:MSSIT RS04255
gene id: 1434120:MSSIT_RS04255
uniprot id: A0A0E3P283
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS10005
gene id: 1434120:MSSIT_RS10005
uniprot id: A0A0E3P4X7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS02235
gene id: 1434120:MSSIT_RS02235
uniprot id: A0A0E3P1A8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

1434120:MSSIT RS08240
gene id: 1434120:MSSIT_RS08240
uniprot id: A0A0E3L8C3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1434120:MSSIT RS10470
gene id: 1434120:MSSIT_RS10470
uniprot id: A0A0E3P526
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1434120:MSSIT RS13055
gene id: 1434120:MSSIT_RS13055
uniprot id: A0A0E3P899
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS14410
gene id: 1434120:MSSIT_RS14410
uniprot id: A0A0E3P8U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS19375
gene id: 1434120:MSSIT_RS19375
uniprot id: A0A0E3P8R0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS08335
gene id: 1434120:MSSIT_RS08335
uniprot id: A0A0E3P405
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09660
gene id: 1434120:MSSIT_RS09660
uniprot id: A0A0E3P6U1
names: Similarity
messages: Belongs to the UPF0758 family.

1434120:MSSIT RS03015
gene id: 1434120:MSSIT_RS03015
uniprot id: A0A0E3P1M8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1434120:MSSIT RS08060
gene id: 1434120:MSSIT_RS08060
uniprot id: A0A0E3L8B6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1434120:MSSIT RS00380
gene id: 1434120:MSSIT_RS00380
uniprot id: A0A0E3L7H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

1434120:MSSIT RS06975
gene id: 1434120:MSSIT_RS06975
uniprot id: A0A0E3L874
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17140
gene id: 1434120:MSSIT_RS17140
uniprot id: A0A0E3P9Z4
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS20405
gene id: 1434120:MSSIT_RS20405
uniprot id: A0A0E3PBA4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1434120:MSSIT RS03960
gene id: 1434120:MSSIT_RS03960
uniprot id: A0A0E3P232
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS12055
gene id: 1434120:MSSIT_RS12055
uniprot id: A0A0E3P5L1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434120:MSSIT RS05785
gene id: 1434120:MSSIT_RS05785
uniprot id: A0A0E3L832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS10010
gene id: 1434120:MSSIT_RS10010
uniprot id: A0A0E3L8J0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS01370
gene id: 1434120:MSSIT_RS01370
uniprot id: A0A0E3P3C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS14400
gene id: 1434120:MSSIT_RS14400
uniprot id: A0A0E3P6L7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS10795
gene id: 1434120:MSSIT_RS10795
uniprot id: A0A0E3P7C1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00145
gene id: 1434120:MSSIT_RS00145
uniprot id: A0A0E3P0L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1434120:MSSIT RS07170
gene id: 1434120:MSSIT_RS07170
uniprot id: A0A0E3P3P4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1434120:MSSIT RS04410
gene id: 1434120:MSSIT_RS04410
uniprot id: A0A0E3P2A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434120:MSSIT RS00525
gene id: 1434120:MSSIT_RS00525
uniprot id: A0A0E3P0G7
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1434120:MSSIT RS10050
gene id: 1434120:MSSIT_RS10050
uniprot id: A0A0E3P4E6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05430
gene id: 1434120:MSSIT_RS05430
uniprot id: A0A0E3P574
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1434120:MSSIT RS13690
gene id: 1434120:MSSIT_RS13690
uniprot id: A0A0E3P8K9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS00290
gene id: 1434120:MSSIT_RS00290
uniprot id: A0A0E3P2W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS18735
gene id: 1434120:MSSIT_RS18735
uniprot id: A0A0E3P8Q1
names: Similarity
messages: Belongs to the UPF0292 family.

1434120:MSSIT RS00010
gene id: 1434120:MSSIT_RS00010
uniprot id: A0A0E3L7G3
names: Similarity
messages: Belongs to the UPF0200 family.

1434120:MSSIT RS14110
gene id: 1434120:MSSIT_RS14110
uniprot id: A0A0E3P6G0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00015
gene id: 1434120:MSSIT_RS00015
uniprot id: A0A0E3P2S5
names: Similarity
messages: Belongs to the UPF0201 family.

1434120:MSSIT RS03295
gene id: 1434120:MSSIT_RS03295
uniprot id: A0A0E3P1T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS05730
gene id: 1434120:MSSIT_RS05730
uniprot id: A0A0E3P2U9
names: Similarity
messages: Belongs to the HupF/HypC family.

1434120:MSSIT RS01860
gene id: 1434120:MSSIT_RS01860
uniprot id: A0A0E3P169
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1434120:MSSIT RS11050
gene id: 1434120:MSSIT_RS11050
uniprot id: A0A0E3P561
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

1434120:MSSIT RS08720
gene id: 1434120:MSSIT_RS08720
uniprot id: A0A0E3P470
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1434120:MSSIT RS03110
gene id: 1434120:MSSIT_RS03110
uniprot id: A0A0E3L7S9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00460
gene id: 1434120:MSSIT_RS00460
uniprot id: A0A0E3P0G2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS20695
gene id: 1434120:MSSIT_RS20695
uniprot id: A0A0E3P9D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1434120:MSSIT RS10780
gene id: 1434120:MSSIT_RS10780
uniprot id: A0A0E3P560
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS15740
gene id: 1434120:MSSIT_RS15740
uniprot id: A0A0E3P9A4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1434120:MSSIT RS16665
gene id: 1434120:MSSIT_RS16665
uniprot id: A0A0E3P7L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

1434120:MSSIT RS01730
gene id: 1434120:MSSIT_RS01730
uniprot id: A0A0E3P155
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS00335
gene id: 1434120:MSSIT_RS00335
uniprot id: A0A0E3P0N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1434120:MSSIT RS00235
gene id: 1434120:MSSIT_RS00235
uniprot id: A0A0E3L7H0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09760
gene id: 1434120:MSSIT_RS09760
uniprot id: A0A0E3P6V9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434120:MSSIT RS08070
gene id: 1434120:MSSIT_RS08070
uniprot id: A0A0E3P3I1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1434120:MSSIT RS06565
gene id: 1434120:MSSIT_RS06565
uniprot id: A0A0E3L861
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1434120:MSSIT RS04350
gene id: 1434120:MSSIT_RS04350
uniprot id: A0A0E3P296
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434120:MSSIT RS12715
gene id: 1434120:MSSIT_RS12715
uniprot id: A0A0E3P5X5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS09455
gene id: 1434120:MSSIT_RS09455
uniprot id: A0A0E3P4M9
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS06515
gene id: 1434120:MSSIT_RS06515
uniprot id: A0A0E3P369
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS09500
gene id: 1434120:MSSIT_RS09500
uniprot id: A0A0E3P4J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434120:MSSIT RS01950
gene id: 1434120:MSSIT_RS01950
uniprot id: A0A0E3P180
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1434120:MSSIT RS12335
gene id: 1434120:MSSIT_RS12335
uniprot id: A0A0E3L8S7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS04080
gene id: 1434120:MSSIT_RS04080
uniprot id: A0A0E3L7W7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS04500
gene id: 1434120:MSSIT_RS04500
uniprot id: A0A0E3L7Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434120:MSSIT RS10375
gene id: 1434120:MSSIT_RS10375
uniprot id: A0A0E3P4U9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17505
gene id: 1434120:MSSIT_RS17505
uniprot id: A0A0E3PA47
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1434120:MSSIT RS07755
gene id: 1434120:MSSIT_RS07755
uniprot id: A0A0E3L8A4
names: Similarity
messages: Belongs to the HsdR family.

1434120:MSSIT RS02660
gene id: 1434120:MSSIT_RS02660
uniprot id: A0A0E3L7R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1434120:MSSIT RS02635
gene id: 1434120:MSSIT_RS02635
uniprot id: A0A0E3L7R1
names: Similarity
messages: Belongs to the Ahb/Nir family.

1434120:MSSIT RS20925
gene id: 1434120:MSSIT_RS20925
uniprot id: A0A0E3P9H1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

1434120:MSSIT RS03955
gene id: 1434120:MSSIT_RS03955
uniprot id: A0A0E3L7W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS07780
gene id: 1434120:MSSIT_RS07780
uniprot id: A0A0E3L8A5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS15440
gene id: 1434120:MSSIT_RS15440
uniprot id: A0A0E3L947
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

1434120:MSSIT RS02710
gene id: 1434120:MSSIT_RS02710
uniprot id: A0A0E3L7R4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1434120:MSSIT RS01030
gene id: 1434120:MSSIT_RS01030
uniprot id: A0A0E3P0P3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1434120:MSSIT RS07830
gene id: 1434120:MSSIT_RS07830
uniprot id: A0A0E3P3G5
names: Similarity
messages: Belongs to the UPF0111 family.

1434120:MSSIT RS00490
gene id: 1434120:MSSIT_RS00490
uniprot id: A0A0E3P0G5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1434120:MSSIT RS04915
gene id: 1434120:MSSIT_RS04915
uniprot id: A0A0E3P2H6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1434120:MSSIT RS14860
gene id: 1434120:MSSIT_RS14860
uniprot id: A0A0E3P6U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1434120:MSSIT RS10535
gene id: 1434120:MSSIT_RS10535
uniprot id: A0A0E3P4M1
names: Function
messages: Part of a potassium transport system.

1434120:MSSIT RS20160
gene id: 1434120:MSSIT_RS20160
uniprot id: A0A0E3P9A1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434120:MSSIT RS03905
gene id: 1434120:MSSIT_RS03905
uniprot id: A0A0E3P221
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1434120:MSSIT RS09265
gene id: 1434120:MSSIT_RS09265
uniprot id: A0A0E3P4K9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1434120:MSSIT RS06760
gene id: 1434120:MSSIT_RS06760
uniprot id: A0A0E3P5Q6
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

1434120:MSSIT RS15900
gene id: 1434120:MSSIT_RS15900
uniprot id: A0A0E3L965
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS04865
gene id: 1434120:MSSIT_RS04865
uniprot id: A0A0E3P4W8
names: Similarity
messages: Belongs to the UPF0173 family.

1434120:MSSIT RS05825
gene id: 1434120:MSSIT_RS05825
uniprot id: A0A0E3P341
names: Similarity
messages: Belongs to the peptidase C1 family.

1434120:MSSIT RS19620
gene id: 1434120:MSSIT_RS19620
uniprot id: A0A0E3P8T5
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1434120:MSSIT RS10185
gene id: 1434120:MSSIT_RS10185
uniprot id: A0A0E3P4T3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17460
gene id: 1434120:MSSIT_RS17460
uniprot id: A0A0E3L9C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434120:MSSIT RS13315
gene id: 1434120:MSSIT_RS13315
uniprot id: A0A0E3P665
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1434120:MSSIT RS13090
gene id: 1434120:MSSIT_RS13090
uniprot id: A0A0E3P8A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434120:MSSIT RS20285
gene id: 1434120:MSSIT_RS20285
uniprot id: A0A0E3PB83
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434120:MSSIT RS05065
gene id: 1434120:MSSIT_RS05065
uniprot id: A0A0E3P2J7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

1434120:MSSIT RS18275
gene id: 1434120:MSSIT_RS18275
uniprot id: A0A0E3P8H5
names: Similarity
messages: Belongs to the glutamate synthase family.

1434120:MSSIT RS14580
gene id: 1434120:MSSIT_RS14580
uniprot id: A0A0E3P8W5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1434120:MSSIT RS05300
gene id: 1434120:MSSIT_RS05300
uniprot id: A0A0E3L813
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1434120:MSSIT RS20325
gene id: 1434120:MSSIT_RS20325
uniprot id: A0A0E3L9N1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS15010
gene id: 1434120:MSSIT_RS15010
uniprot id: A0A0E3P6U6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS04470
gene id: 1434120:MSSIT_RS04470
uniprot id: A0A0E3L7Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434120:MSSIT RS00485
gene id: 1434120:MSSIT_RS00485
uniprot id: A0A0E3P0Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1434120:MSSIT RS10060
gene id: 1434120:MSSIT_RS10060
uniprot id: A0A0E3P720
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS11855
gene id: 1434120:MSSIT_RS11855
uniprot id: A0A0E3P5K0
names: Similarity
messages: Belongs to the sulfatase family.

1434120:MSSIT RS11340
gene id: 1434120:MSSIT_RS11340
uniprot id: A0A0E3P5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS09065
gene id: 1434120:MSSIT_RS09065
uniprot id: A0A0E3P4H0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS00615
gene id: 1434120:MSSIT_RS00615
uniprot id: A0A0E3P0T2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1434120:MSSIT RS15820
gene id: 1434120:MSSIT_RS15820
uniprot id: A0A0E3P777
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1434120:MSSIT RS11415
gene id: 1434120:MSSIT_RS11415
uniprot id: A0A0E3P4Z1
names: Similarity
messages: Belongs to the oxoprolinase family.

1434120:MSSIT RS19170
gene id: 1434120:MSSIT_RS19170
uniprot id: A0A0E3P8N0
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00300
gene id: 1434120:MSSIT_RS00300
uniprot id: A0A0E3P0L7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS14715
gene id: 1434120:MSSIT_RS14715
uniprot id: A0A0E3P6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1434120:MSSIT RS00690
gene id: 1434120:MSSIT_RS00690
uniprot id: A0A0E3L7I6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS17235
gene id: 1434120:MSSIT_RS17235
uniprot id: A0A0E3P810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS18860
gene id: 1434120:MSSIT_RS18860
uniprot id: A0A0E3P8R8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434120:MSSIT RS15395
gene id: 1434120:MSSIT_RS15395
uniprot id: A0A0E3P722
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS01980
gene id: 1434120:MSSIT_RS01980
uniprot id: A0A0E3P3M9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09545
gene id: 1434120:MSSIT_RS09545
uniprot id: A0A0E3P434
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434120:MSSIT RS13335
gene id: 1434120:MSSIT_RS13335
uniprot id: A0A0E3L8W6
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

1434120:MSSIT RS14650
gene id: 1434120:MSSIT_RS14650
uniprot id: A0A0E3L916
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1434120:MSSIT RS19235
gene id: 1434120:MSSIT_RS19235
uniprot id: A0A0E3L9J0
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1434120:MSSIT RS25005
gene id: 1434120:MSSIT_RS25005
uniprot id: A0A0E3P702
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1434120:MSSIT RS05650
gene id: 1434120:MSSIT_RS05650
uniprot id: A0A0E3P2T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1434120:MSSIT RS06520
gene id: 1434120:MSSIT_RS06520
uniprot id: A0A0E3P5M8
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS09070
gene id: 1434120:MSSIT_RS09070
uniprot id: A0A0E3P3W5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03390
gene id: 1434120:MSSIT_RS03390
uniprot id: A0A0E3L7U0
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1434120:MSSIT RS04835
gene id: 1434120:MSSIT_RS04835
uniprot id: A0A0E3P4V9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS20970
gene id: 1434120:MSSIT_RS20970
uniprot id: A0A0E3P9F6
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

1434120:MSSIT RS07915
gene id: 1434120:MSSIT_RS07915
uniprot id: A0A0E3P3W4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS04295
gene id: 1434120:MSSIT_RS04295
uniprot id: A0A0E3L7X5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1434120:MSSIT RS16680
gene id: 1434120:MSSIT_RS16680
uniprot id: A0A0E3P7N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434120:MSSIT RS16020
gene id: 1434120:MSSIT_RS16020
uniprot id: A0A0E3P799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434120:MSSIT RS04280
gene id: 1434120:MSSIT_RS04280
uniprot id: A0A0E3P4N0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1434120:MSSIT RS11175
gene id: 1434120:MSSIT_RS11175
uniprot id: A0A0E3L8N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

1434120:MSSIT RS01200
gene id: 1434120:MSSIT_RS01200
uniprot id: A0A0E3L7K6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1434120:MSSIT RS06315
gene id: 1434120:MSSIT_RS06315
uniprot id: A0A0E3P339
names: Function
messages: Part of a potassium transport system.

1434120:MSSIT RS17065
gene id: 1434120:MSSIT_RS17065
uniprot id: A0A0E3P9Y4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS02505
gene id: 1434120:MSSIT_RS02505
uniprot id: A0A0E3P3W7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS20260
gene id: 1434120:MSSIT_RS20260
uniprot id: A0A0E3P9B3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1434120:MSSIT RS05335
gene id: 1434120:MSSIT_RS05335
uniprot id: A0A0E3P2K1
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03100
gene id: 1434120:MSSIT_RS03100
uniprot id: A0A0E3P1V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434120:MSSIT RS15185
gene id: 1434120:MSSIT_RS15185
uniprot id: A0A0E3P6X3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1434120:MSSIT RS17545
gene id: 1434120:MSSIT_RS17545
uniprot id: A0A0E3P855
names: Similarity
messages: Belongs to the AOR/FOR family.

1434120:MSSIT RS15995
gene id: 1434120:MSSIT_RS15995
uniprot id: A0A0E3P7B8
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434120:MSSIT RS20265
gene id: 1434120:MSSIT_RS20265
uniprot id: A0A0E3P960
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1434120:MSSIT RS16920
gene id: 1434120:MSSIT_RS16920
uniprot id: A0A0E3P7W1
names: Similarity
messages: Belongs to the UPF0285 family.

1434120:MSSIT RS02655
gene id: 1434120:MSSIT_RS02655
uniprot id: A0A0E3P3Z0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1434120:MSSIT RS20755
gene id: 1434120:MSSIT_RS20755
uniprot id: A0A0E3PBF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1434120:MSSIT RS13365
gene id: 1434120:MSSIT_RS13365
uniprot id: A0A0E3P8G4
names: Similarity
messages: Belongs to the peptidase C56 family.

1434120:MSSIT RS16895
gene id: 1434120:MSSIT_RS16895
uniprot id: A0A0E3P7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434120:MSSIT RS03560
gene id: 1434120:MSSIT_RS03560
uniprot id: A0A0E3P1V3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS21000
gene id: 1434120:MSSIT_RS21000
uniprot id: A0A0E3P0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

1434120:MSSIT RS19100
gene id: 1434120:MSSIT_RS19100
uniprot id: A0A0E3P8J6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS18055
gene id: 1434120:MSSIT_RS18055
uniprot id: A0A0E3P842
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434120:MSSIT RS14880
gene id: 1434120:MSSIT_RS14880
uniprot id: A0A0E3P8Z5
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1434120:MSSIT RS14655
gene id: 1434120:MSSIT_RS14655
uniprot id: A0A0E3P6Q9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1434120:MSSIT RS01570
gene id: 1434120:MSSIT_RS01570
uniprot id: A0A0E3P132
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1434120:MSSIT RS05760
gene id: 1434120:MSSIT_RS05760
uniprot id: A0A0E3P2V5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434120:MSSIT RS00345
gene id: 1434120:MSSIT_RS00345
uniprot id: A0A0E3L7H4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1434120:MSSIT RS05765
gene id: 1434120:MSSIT_RS05765
uniprot id: A0A0E3L831
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1434120:MSSIT RS18655
gene id: 1434120:MSSIT_RS18655
uniprot id: A0A0E3P8C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS14750
gene id: 1434120:MSSIT_RS14750
uniprot id: A0A0E3P6S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434120:MSSIT RS07515
gene id: 1434120:MSSIT_RS07515
uniprot id: A0A0E3L894
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1434120:MSSIT RS05330
gene id: 1434120:MSSIT_RS05330
uniprot id: A0A0E3L814
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434120:MSSIT RS19130
gene id: 1434120:MSSIT_RS19130
uniprot id: A0A0E3P8M6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS16945
gene id: 1434120:MSSIT_RS16945
uniprot id: A0A0E3P9W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434120:MSSIT RS14165
gene id: 1434120:MSSIT_RS14165
uniprot id: A0A0E3P6I7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS03895
gene id: 1434120:MSSIT_RS03895
uniprot id: A0A0E3P298
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434120:MSSIT RS10410
gene id: 1434120:MSSIT_RS10410
uniprot id: A0A0E3P4V4
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00925
gene id: 1434120:MSSIT_RS00925
uniprot id: A0A0E3P0M8
names: Similarity
messages: Belongs to the UPF0166 family.

1434120:MSSIT RS12475
gene id: 1434120:MSSIT_RS12475
uniprot id: A0A0E3L8T2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1434120:MSSIT RS09670
gene id: 1434120:MSSIT_RS09670
uniprot id: A0A0E3P4L9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1434120:MSSIT RS15850
gene id: 1434120:MSSIT_RS15850
uniprot id: A0A0E3P780
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS18685
gene id: 1434120:MSSIT_RS18685
uniprot id: A0A0E3P8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434120:MSSIT RS15750
gene id: 1434120:MSSIT_RS15750
uniprot id: A0A0E3P765
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1434120:MSSIT RS09775
gene id: 1434120:MSSIT_RS09775
uniprot id: A0A0E3P4U7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1434120:MSSIT RS18725
gene id: 1434120:MSSIT_RS18725
uniprot id: A0A0E3PAH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1434120:MSSIT RS11495
gene id: 1434120:MSSIT_RS11495
uniprot id: A0A0E3P5D7
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17910
gene id: 1434120:MSSIT_RS17910
uniprot id: A0A0E3P847
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

1434120:MSSIT RS20430
gene id: 1434120:MSSIT_RS20430
uniprot id: A0A0E3P981
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1434120:MSSIT RS09195
gene id: 1434120:MSSIT_RS09195
uniprot id: A0A0E3P4E7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1434120:MSSIT RS20275
gene id: 1434120:MSSIT_RS20275
uniprot id: A0A0E3L9M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1434120:MSSIT RS08725
gene id: 1434120:MSSIT_RS08725
uniprot id: A0A0E3P6E1
names: Similarity
messages: Belongs to the TrpC family.

1434120:MSSIT RS09020
gene id: 1434120:MSSIT_RS09020
uniprot id: A0A0E3P4B6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS00295
gene id: 1434120:MSSIT_RS00295
uniprot id: A0A0E3L7H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS02415
gene id: 1434120:MSSIT_RS02415
uniprot id: A0A0E3P3V1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS18020
gene id: 1434120:MSSIT_RS18020
uniprot id: A0A0E3P863
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1434120:MSSIT RS17630
gene id: 1434120:MSSIT_RS17630
uniprot id: A0A0E3PA60
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00980
gene id: 1434120:MSSIT_RS00980
uniprot id: A0A0E3P0P0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1434120:MSSIT RS08955
gene id: 1434120:MSSIT_RS08955
uniprot id: A0A0E3P4F6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434120:MSSIT RS16950
gene id: 1434120:MSSIT_RS16950
uniprot id: A0A0E3P7W4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434120:MSSIT RS13470
gene id: 1434120:MSSIT_RS13470
uniprot id: A0A0E3P8H9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS05030
gene id: 1434120:MSSIT_RS05030
uniprot id: A0A0E3P2F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1434120:MSSIT RS08210
gene id: 1434120:MSSIT_RS08210
uniprot id: A0A0E3P3J8
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1434120:MSSIT RS00305
gene id: 1434120:MSSIT_RS00305
uniprot id: A0A0E3P0N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS10340
gene id: 1434120:MSSIT_RS10340
uniprot id: A0A0E3P4U6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS00340
gene id: 1434120:MSSIT_RS00340
uniprot id: A0A0E3P0E9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434120:MSSIT RS03535
gene id: 1434120:MSSIT_RS03535
uniprot id: A0A0E3P1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1434120:MSSIT RS08065
gene id: 1434120:MSSIT_RS08065
uniprot id: A0A0E3P438
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1434120:MSSIT RS13380
gene id: 1434120:MSSIT_RS13380
uniprot id: A0A0E3P674
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS07900
gene id: 1434120:MSSIT_RS07900
uniprot id: A0A0E3P3U4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434120:MSSIT RS06235
gene id: 1434120:MSSIT_RS06235
uniprot id: A0A0E3L849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1434120:MSSIT RS17915
gene id: 1434120:MSSIT_RS17915
uniprot id: A0A0E3P828
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1434120:MSSIT RS01245
gene id: 1434120:MSSIT_RS01245
uniprot id: A0A0E3P0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434120:MSSIT RS17990
gene id: 1434120:MSSIT_RS17990
uniprot id: A0A0E3P857
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1434120:MSSIT RS11920
gene id: 1434120:MSSIT_RS11920
uniprot id: A0A0E3P5K5
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05165
gene id: 1434120:MSSIT_RS05165
uniprot id: A0A0E3P2U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1434120:MSSIT RS05980
gene id: 1434120:MSSIT_RS05980
uniprot id: A0A0E3L840
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS16865
gene id: 1434120:MSSIT_RS16865
uniprot id: A0A0E3L9A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1434120:MSSIT RS00255
gene id: 1434120:MSSIT_RS00255
uniprot id: A0A0E3P2W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1434120:MSSIT RS03520
gene id: 1434120:MSSIT_RS03520
uniprot id: A0A0E3P1W4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1434120:MSSIT RS17735
gene id: 1434120:MSSIT_RS17735
uniprot id: A0A0E3L9D6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS17400
gene id: 1434120:MSSIT_RS17400
uniprot id: A0A0E3P7W7
names: Similarity
messages: Belongs to the DEAD box helicase family.

1434120:MSSIT RS22595
gene id: 1434120:MSSIT_RS22595
uniprot id: A0A0E3P7X3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1434120:MSSIT RS17655
gene id: 1434120:MSSIT_RS17655
uniprot id: A0A0E3L9D3
names: Subcellular Location Annotation
messages: Cell membrane

1434120:MSSIT RS04070
gene id: 1434120:MSSIT_RS04070
uniprot id: A0A0E3P216
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS10380
gene id: 1434120:MSSIT_RS10380
uniprot id: A0A0E3L8K3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS04140
gene id: 1434120:MSSIT_RS04140
uniprot id: A0A0E3P4L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS17145
gene id: 1434120:MSSIT_RS17145
uniprot id: A0A0E3L9B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434120:MSSIT RS10175
gene id: 1434120:MSSIT_RS10175
uniprot id: A0A0E3P4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS18560
gene id: 1434120:MSSIT_RS18560
uniprot id: A0A0E3P8E3
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434120:MSSIT RS02640
gene id: 1434120:MSSIT_RS02640
uniprot id: A0A0E3P1P8
names: Similarity
messages: Belongs to the Ahb/Nir family.

1434120:MSSIT RS15465
gene id: 1434120:MSSIT_RS15465
uniprot id: A0A0E3P963
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434120:MSSIT RS10200
gene id: 1434120:MSSIT_RS10200
uniprot id: A0A0E3P4W2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1434120:MSSIT RS14205
gene id: 1434120:MSSIT_RS14205
uniprot id: A0A0E3P6H6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434120:MSSIT RS01270
gene id: 1434120:MSSIT_RS01270
uniprot id: A0A0E3P0T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434120:MSSIT RS11640
gene id: 1434120:MSSIT_RS11640
uniprot id: A0A0E3P544
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434120:MSSIT RS18230
gene id: 1434120:MSSIT_RS18230
uniprot id: A0A0E3PAC1
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS17070
gene id: 1434120:MSSIT_RS17070
uniprot id: A0A0E3P7Y8
names: Similarity
messages: Belongs to the UPF0284 family.

1434120:MSSIT RS16890
gene id: 1434120:MSSIT_RS16890
uniprot id: A0A0E3P7V2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1434120:MSSIT RS15400
gene id: 1434120:MSSIT_RS15400
uniprot id: A0A0E3P704
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS17920
gene id: 1434120:MSSIT_RS17920
uniprot id: A0A0E3L9E3
names: Similarity
messages: Belongs to the AAA ATPase family.

1434120:MSSIT RS04780
gene id: 1434120:MSSIT_RS04780
uniprot id: A0A0E3P2N2
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS03360
gene id: 1434120:MSSIT_RS03360
uniprot id: A0A0E3P1T9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS16675
gene id: 1434120:MSSIT_RS16675
uniprot id: A0A0E3P7S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434120:MSSIT RS00825
gene id: 1434120:MSSIT_RS00825
uniprot id: A0A0E3P0L3
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS10740
gene id: 1434120:MSSIT_RS10740
uniprot id: A0A0E3L8L6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

1434120:MSSIT RS07180
gene id: 1434120:MSSIT_RS07180
uniprot id: A0A0E3P3H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS14240
gene id: 1434120:MSSIT_RS14240
uniprot id: A0A0E3P6H9
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1434120:MSSIT RS15475
gene id: 1434120:MSSIT_RS15475
uniprot id: A0A0E3P729
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS04075
gene id: 1434120:MSSIT_RS04075
uniprot id: A0A0E3P4K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS20085
gene id: 1434120:MSSIT_RS20085
uniprot id: A0A0E3L9M2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1434120:MSSIT RS11905
gene id: 1434120:MSSIT_RS11905
uniprot id: A0A0E3L8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434120:MSSIT RS17300
gene id: 1434120:MSSIT_RS17300
uniprot id: A0A0E3P816
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1434120:MSSIT RS15760
gene id: 1434120:MSSIT_RS15760
uniprot id: A0A0E3P779
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1434120:MSSIT RS00610
gene id: 1434120:MSSIT_RS00610
uniprot id: A0A0E3P0Q8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

1434120:MSSIT RS14075
gene id: 1434120:MSSIT_RS14075
uniprot id: A0A0E3L8Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434120:MSSIT RS19960
gene id: 1434120:MSSIT_RS19960
uniprot id: A0A0E3P912
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS05340
gene id: 1434120:MSSIT_RS05340
uniprot id: A0A0E3P558
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1434120:MSSIT RS14755
gene id: 1434120:MSSIT_RS14755
uniprot id: A0A0E3L920
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS05080
gene id: 1434120:MSSIT_RS05080
uniprot id: A0A0E3P509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

1434120:MSSIT RS00600
gene id: 1434120:MSSIT_RS00600
uniprot id: A0A0E3L7I3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434120:MSSIT RS20090
gene id: 1434120:MSSIT_RS20090
uniprot id: A0A0E3P994
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1434120:MSSIT RS00245
gene id: 1434120:MSSIT_RS00245
uniprot id: A0A0E3P0D0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1434120:MSSIT RS00150
gene id: 1434120:MSSIT_RS00150
uniprot id: A0A0E3P0C0
names: Subcellular Location Annotation
messages: Cytoplasm

1434120:MSSIT RS10385
gene id: 1434120:MSSIT_RS10385
uniprot id: A0A0E3P767
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS11985
gene id: 1434120:MSSIT_RS11985
uniprot id: A0A0E3P5L3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS03385
gene id: 1434120:MSSIT_RS03385
uniprot id: A0A0E3P220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS16215
gene id: 1434120:MSSIT_RS16215
uniprot id: A0A0E3P7J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1434120:MSSIT RS08340
gene id: 1434120:MSSIT_RS08340
uniprot id: A0A0E3P689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1434120:MSSIT RS05655
gene id: 1434120:MSSIT_RS05655
uniprot id: A0A0E3P2Q1
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1434120:MSSIT RS05240
gene id: 1434120:MSSIT_RS05240
uniprot id: A0A0E3P2I3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS00855
gene id: 1434120:MSSIT_RS00855
uniprot id: A0A0E3P0L9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1434120:MSSIT RS06730
gene id: 1434120:MSSIT_RS06730
uniprot id: A0A0E3P3D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1434120:MSSIT RS08385
gene id: 1434120:MSSIT_RS08385
uniprot id: A0A0E3P432
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS21565
gene id: 1434120:MSSIT_RS21565
uniprot id: A0A0E3P0X6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS07950
gene id: 1434120:MSSIT_RS07950
uniprot id: A0A0E3P3U9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS13845
gene id: 1434120:MSSIT_RS13845
uniprot id: A0A0E3P6C1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434120:MSSIT RS13085
gene id: 1434120:MSSIT_RS13085
uniprot id: A0A0E3P613
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434120:MSSIT RS01700
gene id: 1434120:MSSIT_RS01700
uniprot id: A0A0E3L7M6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1434120:MSSIT RS17315
gene id: 1434120:MSSIT_RS17315
uniprot id: A0A0E3L9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS12900
gene id: 1434120:MSSIT_RS12900
uniprot id: A0A0E3P877
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

1434120:MSSIT RS15275
gene id: 1434120:MSSIT_RS15275
uniprot id: A0A0E3P701
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12470
gene id: 1434120:MSSIT_RS12470
uniprot id: A0A0E3P836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434120:MSSIT RS14475
gene id: 1434120:MSSIT_RS14475
uniprot id: A0A0E3P8V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS13125
gene id: 1434120:MSSIT_RS13125
uniprot id: A0A0E3L8V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1434120:MSSIT RS06915
gene id: 1434120:MSSIT_RS06915
uniprot id: A0A0E3P3C8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS18715
gene id: 1434120:MSSIT_RS18715
uniprot id: A0A0E3P8G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1434120:MSSIT RS14125
gene id: 1434120:MSSIT_RS14125
uniprot id: A0A0E3L8Z6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434120:MSSIT RS17770
gene id: 1434120:MSSIT_RS17770
uniprot id: A0A0E3P894
names: Similarity
messages: Belongs to the UPF0228 family.

1434120:MSSIT RS04235
gene id: 1434120:MSSIT_RS04235
uniprot id: A0A0E3P273
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1434120:MSSIT RS00750
gene id: 1434120:MSSIT_RS00750
uniprot id: A0A0E3P0V4
names: Similarity
messages: Belongs to the UPF0251 family.

1434120:MSSIT RS05145
gene id: 1434120:MSSIT_RS05145
uniprot id: A0A0E3P2H0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434120:MSSIT RS11765
gene id: 1434120:MSSIT_RS11765
uniprot id: A0A0E3P7P7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1434120:MSSIT RS15550
gene id: 1434120:MSSIT_RS15550
uniprot id: A0A0E3P727
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS08885
gene id: 1434120:MSSIT_RS08885
uniprot id: A0A0E3P493
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1434120:MSSIT RS07525
gene id: 1434120:MSSIT_RS07525
uniprot id: A0A0E3P5Z4
names: Function
names: Subcellular Location Annotation
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

1434120:MSSIT RS19530
gene id: 1434120:MSSIT_RS19530
uniprot id: A0A0E3PAT5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434120:MSSIT RS15770
gene id: 1434120:MSSIT_RS15770
uniprot id: A0A0E3P9A9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1434120:MSSIT RS13855
gene id: 1434120:MSSIT_RS13855
uniprot id: A0A0E3P6G7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434120:MSSIT RS03620
gene id: 1434120:MSSIT_RS03620
uniprot id: A0A0E3L7U9
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14710
gene id: 1434120:MSSIT_RS14710
uniprot id: A0A0E3P6W2
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS07585
gene id: 1434120:MSSIT_RS07585
uniprot id: A0A0E3P3N6
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS04095
gene id: 1434120:MSSIT_RS04095
uniprot id: A0A0E3P252
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

1434120:MSSIT RS15065
gene id: 1434120:MSSIT_RS15065
uniprot id: A0A0E3P6V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

1434120:MSSIT RS17035
gene id: 1434120:MSSIT_RS17035
uniprot id: A0A0E3P9X9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1434120:MSSIT RS15950
gene id: 1434120:MSSIT_RS15950
uniprot id: A0A0E3L967
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS08785
gene id: 1434120:MSSIT_RS08785
uniprot id: A0A0E3P476
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1434120:MSSIT RS12645
gene id: 1434120:MSSIT_RS12645
uniprot id: A0A0E3P5W8
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1434120:MSSIT RS17980
gene id: 1434120:MSSIT_RS17980
uniprot id: A0A0E3P892
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434120:MSSIT RS14080
gene id: 1434120:MSSIT_RS14080
uniprot id: A0A0E3P6F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434120:MSSIT RS19135
gene id: 1434120:MSSIT_RS19135
uniprot id: A0A0E3P8K1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1434120:MSSIT RS02050
gene id: 1434120:MSSIT_RS02050
uniprot id: A0A0E3P1I3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1434120:MSSIT RS15080
gene id: 1434120:MSSIT_RS15080
uniprot id: A0A0E3P714
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1434120:MSSIT RS08205
gene id: 1434120:MSSIT_RS08205
uniprot id: A0A0E3P455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1434120:MSSIT RS03950
gene id: 1434120:MSSIT_RS03950
uniprot id: A0A0E3P4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS17100
gene id: 1434120:MSSIT_RS17100
uniprot id: A0A0E3P7S8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1434120:MSSIT RS14020
gene id: 1434120:MSSIT_RS14020
uniprot id: A0A0E3P8P8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1434120:MSSIT RS16640
gene id: 1434120:MSSIT_RS16640
uniprot id: A0A0E3L993
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1434120:MSSIT RS07825
gene id: 1434120:MSSIT_RS07825
uniprot id: A0A0E3P3U7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1434120:MSSIT RS02800
gene id: 1434120:MSSIT_RS02800
uniprot id: A0A0E3P1I5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1434120:MSSIT RS05210
gene id: 1434120:MSSIT_RS05210
uniprot id: A0A0E3L809
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1434120:MSSIT RS15795
gene id: 1434120:MSSIT_RS15795
uniprot id: A0A0E3P761
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1434120:MSSIT RS20690
gene id: 1434120:MSSIT_RS20690
uniprot id: A0A0E3L9P6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS18360
gene id: 1434120:MSSIT_RS18360
uniprot id: A0A0E3P8B3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434120:MSSIT RS12530
gene id: 1434120:MSSIT_RS12530
uniprot id: A0A0E3L8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434120:MSSIT RS14245
gene id: 1434120:MSSIT_RS14245
uniprot id: A0A0E3P8S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1434120:MSSIT RS12340
gene id: 1434120:MSSIT_RS12340
uniprot id: A0A0E3P5S0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS15305
gene id: 1434120:MSSIT_RS15305
uniprot id: A0A0E3P705
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS12320
gene id: 1434120:MSSIT_RS12320
uniprot id: A0A0E3P5H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS04860
gene id: 1434120:MSSIT_RS04860
uniprot id: A0A0E3P2C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

1434120:MSSIT RS04025
gene id: 1434120:MSSIT_RS04025
uniprot id: A0A0E3P2B6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434120:MSSIT RS08840
gene id: 1434120:MSSIT_RS08840
uniprot id: A0A0E3P486
names: Subcellular Location Annotation
messages: Cytoplasm

1434120:MSSIT RS08295
gene id: 1434120:MSSIT_RS08295
uniprot id: A0A0E3L8C5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1434120:MSSIT RS09410
gene id: 1434120:MSSIT_RS09410
uniprot id: A0A0E3P6Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1434120:MSSIT RS05885
gene id: 1434120:MSSIT_RS05885
uniprot id: A0A0E3P2X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1434120:MSSIT RS18545
gene id: 1434120:MSSIT_RS18545
uniprot id: A0A0E3P8L7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1434120:MSSIT RS10260
gene id: 1434120:MSSIT_RS10260
uniprot id: A0A0E3L8J9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1434120:MSSIT RS14050
gene id: 1434120:MSSIT_RS14050
uniprot id: A0A0E3L8Z3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1434120:MSSIT RS11465
gene id: 1434120:MSSIT_RS11465
uniprot id: A0A0E3L8P3
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434120:MSSIT RS08915
gene id: 1434120:MSSIT_RS08915
uniprot id: A0A0E3P6G6
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1434120:MSSIT RS15460
gene id: 1434120:MSSIT_RS15460
uniprot id: A0A0E3L948
names: Similarity
messages: Belongs to the P(II) protein family.

1434120:MSSIT RS18515
gene id: 1434120:MSSIT_RS18515
uniprot id: A0A0E3P8H6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434120:MSSIT RS16055
gene id: 1434120:MSSIT_RS16055
uniprot id: A0A0E3L971
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434120:MSSIT RS12540
gene id: 1434120:MSSIT_RS12540
uniprot id: A0A0E3P845
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS20395
gene id: 1434120:MSSIT_RS20395
uniprot id: A0A0E3L9N4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1434120:MSSIT RS08255
gene id: 1434120:MSSIT_RS08255
uniprot id: A0A0E3P463
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1434120:MSSIT RS03010
gene id: 1434120:MSSIT_RS03010
uniprot id: A0A0E3L7S5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1434120:MSSIT RS00395
gene id: 1434120:MSSIT_RS00395
uniprot id: A0A0E3P2X3
names: Similarity
messages: Belongs to the UPF0147 family.

1434120:MSSIT RS12480
gene id: 1434120:MSSIT_RS12480
uniprot id: A0A0E3P5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1434120:MSSIT RS09430
gene id: 1434120:MSSIT_RS09430
uniprot id: A0A0E3P413
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1434120:MSSIT RS02120
gene id: 1434120:MSSIT_RS02120
uniprot id: A0A0E3P157
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1434120:MSSIT RS05740
gene id: 1434120:MSSIT_RS05740
uniprot id: A0A0E3L830
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1434120:MSSIT RS07520
gene id: 1434120:MSSIT_RS07520
uniprot id: A0A0E3P3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

1434120:MSSIT RS11220
gene id: 1434120:MSSIT_RS11220
uniprot id: A0A0E3L8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1434120:MSSIT RS00590
gene id: 1434120:MSSIT_RS00590
uniprot id: A0A0E3P0H6
names: Similarity
messages: Belongs to the aspartokinase family.

1434120:MSSIT RS03105
gene id: 1434120:MSSIT_RS03105
uniprot id: A0A0E3P1P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434120:MSSIT RS07955
gene id: 1434120:MSSIT_RS07955
uniprot id: A0A0E3P636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434120:MSSIT RS18760
gene id: 1434120:MSSIT_RS18760
uniprot id: A0A0E3P8Q6
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1434120:MSSIT RS10310
gene id: 1434120:MSSIT_RS10310
uniprot id: A0A0E3P4U4
names: Subcellular Location Annotation
messages: Membrane

1434120:MSSIT RS14130
gene id: 1434120:MSSIT_RS14130
uniprot id: A0A0E3P6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434120:MSSIT RS20965
gene id: 1434120:MSSIT_RS20965
uniprot id: A0A0E3P9L0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434120:MSSIT RS02515
gene id: 1434120:MSSIT_RS02515
uniprot id: A0A0E3P1E4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).