1423721:LA20533 RS02605
gene id: 1423721:LA20533_RS02605
uniprot id: A0A0R1YQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. CshA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
messages: Oligomerizes, may be a member of the RNA degradosome.

1423721:LA20533 RS00750
gene id: 1423721:LA20533_RS00750
uniprot id: A0A0R1YKH5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS07935
gene id: 1423721:LA20533_RS07935
uniprot id: A0A0R1YKW8
names: Similarity
messages: Belongs to the peptidase S41A family.

1423721:LA20533 RS02920
gene id: 1423721:LA20533_RS02920
uniprot id: A0A0R1YR00
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03830
gene id: 1423721:LA20533_RS03830
uniprot id: A0A0R1YKW4
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1423721:LA20533 RS06850
gene id: 1423721:LA20533_RS06850
uniprot id: A0A0R1YRW4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1423721:LA20533 RS03725
gene id: 1423721:LA20533_RS03725
uniprot id: A0A0R1YTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1423721:LA20533 RS04595
gene id: 1423721:LA20533_RS04595
uniprot id: A0A1L6XC72
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1423721:LA20533 RS05260
gene id: 1423721:LA20533_RS05260
uniprot id: A0A0R1YNP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1423721:LA20533 RS00310
gene id: 1423721:LA20533_RS00310
uniprot id: A0A0R1YM09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1423721:LA20533 RS00645
gene id: 1423721:LA20533_RS00645
uniprot id: A0A1L6XAA8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1423721:LA20533 RS04115
gene id: 1423721:LA20533_RS04115
uniprot id: A0A0R1YN54
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1423721:LA20533 RS00080
gene id: 1423721:LA20533_RS00080
uniprot id: A0A0R1YSS7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1423721:LA20533 RS06735
gene id: 1423721:LA20533_RS06735
uniprot id: A0A0R1YJX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1423721:LA20533 RS06765
gene id: 1423721:LA20533_RS06765
uniprot id: A0A0R1YJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1423721:LA20533 RS07455
gene id: 1423721:LA20533_RS07455
uniprot id: A0A0R1YKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1423721:LA20533 RS04445
gene id: 1423721:LA20533_RS04445
uniprot id: A0A1L6XC36
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00895
gene id: 1423721:LA20533_RS00895
uniprot id: A0A0R1YT73
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS03850
gene id: 1423721:LA20533_RS03850
uniprot id: A0A1L6XBU7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1423721:LA20533 RS07705
gene id: 1423721:LA20533_RS07705
uniprot id: A0A1L6XDS9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1423721:LA20533 RS05455
gene id: 1423721:LA20533_RS05455
uniprot id: A0A1L6XCN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07340
gene id: 1423721:LA20533_RS07340
uniprot id: A0A0R1YP79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1423721:LA20533 RS01685
gene id: 1423721:LA20533_RS01685
uniprot id: A0A0R1YHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1423721:LA20533 RS01630
gene id: 1423721:LA20533_RS01630
uniprot id: A0A0R1YIL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1423721:LA20533 RS04585
gene id: 1423721:LA20533_RS04585
uniprot id: A0A0R1YWC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS01795
gene id: 1423721:LA20533_RS01795
uniprot id: A0A0R1YHY8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1423721:LA20533 RS01895
gene id: 1423721:LA20533_RS01895
uniprot id: A0A1L6XAW0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1423721:LA20533 RS00670
gene id: 1423721:LA20533_RS00670
uniprot id: A0A0R1YKF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1423721:LA20533 RS07310
gene id: 1423721:LA20533_RS07310
uniprot id: A0A0R1YJJ4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1423721:LA20533 RS02145
gene id: 1423721:LA20533_RS02145
uniprot id: A0A0R1YSI4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1423721:LA20533 RS04400
gene id: 1423721:LA20533_RS04400
uniprot id: A0A0R1YMN0
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1423721:LA20533 RS03590
gene id: 1423721:LA20533_RS03590
uniprot id: A0A1L6XBP7
names: Subcellular Location Annotation
messages: Nucleus

1423721:LA20533 RS07510
gene id: 1423721:LA20533_RS07510
uniprot id: A0A0R1YPB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1423721:LA20533 RS06050
gene id: 1423721:LA20533_RS06050
uniprot id: A0A0R1YIL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04985
gene id: 1423721:LA20533_RS04985
uniprot id: A0A0R1YH74
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS01330
gene id: 1423721:LA20533_RS01330
uniprot id: A0A1L6XAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LTA synthase family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04025
gene id: 1423721:LA20533_RS04025
uniprot id: A0A0R1YMC9
names: Similarity
messages: Belongs to the plasmid mobilization pre family.

1423721:LA20533 RS00775
gene id: 1423721:LA20533_RS00775
uniprot id: A0A0R1YVB4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1423721:LA20533 RS04925
gene id: 1423721:LA20533_RS04925
uniprot id: A0A1L6XCD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1423721:LA20533 RS06935
gene id: 1423721:LA20533_RS06935
uniprot id: A0A0R1YJU0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1423721:LA20533 RS07850
gene id: 1423721:LA20533_RS07850
uniprot id: A0A0R1YSH9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1423721:LA20533 RS00150
gene id: 1423721:LA20533_RS00150
uniprot id: A0A0R1YSR4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1423721:LA20533 RS07945
gene id: 1423721:LA20533_RS07945
uniprot id: A0A0R1YUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

1423721:LA20533 RS04675
gene id: 1423721:LA20533_RS04675
uniprot id: A0A0R1YM48
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1423721:LA20533 RS07965
gene id: 1423721:LA20533_RS07965
uniprot id: A0A0R1YJZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

1423721:LA20533 RS02790
gene id: 1423721:LA20533_RS02790
uniprot id: A0A0R1YJB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1423721:LA20533 RS07825
gene id: 1423721:LA20533_RS07825
uniprot id: A0A0R1YPH7
names: Similarity
messages: Belongs to the CvfB family.

1423721:LA20533 RS03990
gene id: 1423721:LA20533_RS03990
uniprot id: A0A1L6XBX8
names: Function
messages: Involved in the transposition of the insertion sequence.

1423721:LA20533 RS05205
gene id: 1423721:LA20533_RS05205
uniprot id: A0A0R1YGL0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1423721:LA20533 RS07970
gene id: 1423721:LA20533_RS07970
uniprot id: A0A0R1YKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1423721:LA20533 RS00110
gene id: 1423721:LA20533_RS00110
uniprot id: A0A0R1YL92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1423721:LA20533 RS02395
gene id: 1423721:LA20533_RS02395
uniprot id: A0A0R1YSP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1423721:LA20533 RS02330
gene id: 1423721:LA20533_RS02330
uniprot id: A0A0R1YIN7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1423721:LA20533 RS07440
gene id: 1423721:LA20533_RS07440
uniprot id: A0A0R1YK18
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1423721:LA20533 RS00345
gene id: 1423721:LA20533_RS00345
uniprot id: A0A1L6XA92
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1423721:LA20533 RS06315
gene id: 1423721:LA20533_RS06315
uniprot id: A0A0R1YK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1423721:LA20533 RS02325
gene id: 1423721:LA20533_RS02325
uniprot id: A0A1L6XB36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS08120
gene id: 1423721:LA20533_RS08120
uniprot id: A0A1L6XE05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

1423721:LA20533 RS00105
gene id: 1423721:LA20533_RS00105
uniprot id: A0A0R1YK61
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1423721:LA20533 RS02570
gene id: 1423721:LA20533_RS02570
uniprot id: A0A0R1YN03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1423721:LA20533 RS01775
gene id: 1423721:LA20533_RS01775
uniprot id: A0A0R1YIV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1423721:LA20533 RS05505
gene id: 1423721:LA20533_RS05505
uniprot id: A0A0R1YNV2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.

1423721:LA20533 RS03070
gene id: 1423721:LA20533_RS03070
uniprot id: A0A1L6XBG2
names: Similarity
messages: Belongs to the peptidase M13 family.

1423721:LA20533 RS06320
gene id: 1423721:LA20533_RS06320
uniprot id: A0A0R1YJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1423721:LA20533 RS06350
gene id: 1423721:LA20533_RS06350
uniprot id: A0A0R1YRK5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1423721:LA20533 RS00755
gene id: 1423721:LA20533_RS00755
uniprot id: A0A0R1YLM1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

1423721:LA20533 RS02680
gene id: 1423721:LA20533_RS02680
uniprot id: A0A1L6XBA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1423721:LA20533 RS06365
gene id: 1423721:LA20533_RS06365
uniprot id: A0A0R1YRI1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1423721:LA20533 RS04700
gene id: 1423721:LA20533_RS04700
uniprot id: A0A1L6XC88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

1423721:LA20533 RS01030
gene id: 1423721:LA20533_RS01030
uniprot id: A0A1L6XAJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1423721:LA20533 RS01980
gene id: 1423721:LA20533_RS01980
uniprot id: A0A1L6XAY3
names: Similarity
messages: Belongs to the peptidase C1 family.

1423721:LA20533 RS01650
gene id: 1423721:LA20533_RS01650
uniprot id: A0A0R1YIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1423721:LA20533 RS06295
gene id: 1423721:LA20533_RS06295
uniprot id: A0A0R1YTJ5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1423721:LA20533 RS07525
gene id: 1423721:LA20533_RS07525
uniprot id: A0A1L6XDQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1423721:LA20533 RS06670
gene id: 1423721:LA20533_RS06670
uniprot id: A0A0R1YL15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1423721:LA20533 RS07755
gene id: 1423721:LA20533_RS07755
uniprot id: A0A0R1YSG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS05850
gene id: 1423721:LA20533_RS05850
uniprot id: A0A1L6XEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

1423721:LA20533 RS08270
gene id: 1423721:LA20533_RS08270
uniprot id: A0A1L6XA15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS02985
gene id: 1423721:LA20533_RS02985
uniprot id: A0A0R1YR49
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02585
gene id: 1423721:LA20533_RS02585
uniprot id: A0A0R1YIU3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06520
gene id: 1423721:LA20533_RS06520
uniprot id: A0A0R1YJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1423721:LA20533 RS04660
gene id: 1423721:LA20533_RS04660
uniprot id: A0A0R1YR11
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS05600
gene id: 1423721:LA20533_RS05600
uniprot id: A0A0R1YH03
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1423721:LA20533 RS07370
gene id: 1423721:LA20533_RS07370
uniprot id: A0A1L6XDL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1423721:LA20533 RS06530
gene id: 1423721:LA20533_RS06530
uniprot id: A0A0R1YRM0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS06995
gene id: 1423721:LA20533_RS06995
uniprot id: A0A1L6XDF8
names: Function
messages: Required for transformation and DNA binding.

1423721:LA20533 RS07425
gene id: 1423721:LA20533_RS07425
uniprot id: A0A0R1YP96
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1423721:LA20533 RS02595
gene id: 1423721:LA20533_RS02595
uniprot id: A0A1L6XB77
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1423721:LA20533 RS07520
gene id: 1423721:LA20533_RS07520
uniprot id: A0A0R1YSB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsQ/DivIB family. DivIB subfamily.
messages: Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS07070
gene id: 1423721:LA20533_RS07070
uniprot id: A0A1L6XDG9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1423721:LA20533 RS05560
gene id: 1423721:LA20533_RS05560
uniprot id: A0A1L6XCR5
names: Function
messages: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.

1423721:LA20533 RS06040
gene id: 1423721:LA20533_RS06040
uniprot id: A0A0R1YHJ6
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1423721:LA20533 RS08635
gene id: 1423721:LA20533_RS08635
uniprot id: A0A0R1YKW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS02575
gene id: 1423721:LA20533_RS02575
uniprot id: A0A0R1YK65
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1423721:LA20533 RS01955
gene id: 1423721:LA20533_RS01955
uniprot id: A0A1L6XAX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1423721:LA20533 RS07195
gene id: 1423721:LA20533_RS07195
uniprot id: A0A0R1YS09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

1423721:LA20533 RS05555
gene id: 1423721:LA20533_RS05555
uniprot id: A0A0R1YH23
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1423721:LA20533 RS06115
gene id: 1423721:LA20533_RS06115
uniprot id: A0A1L6XEC4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1423721:LA20533 RS07680
gene id: 1423721:LA20533_RS07680
uniprot id: A0A1L6XEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1423721:LA20533 RS02445
gene id: 1423721:LA20533_RS02445
uniprot id: A0A0R1YSN5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1423721:LA20533 RS06965
gene id: 1423721:LA20533_RS06965
uniprot id: A0A1L6XDE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1423721:LA20533 RS01825
gene id: 1423721:LA20533_RS01825
uniprot id: A0A1L6XE79
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

1423721:LA20533 RS00580
gene id: 1423721:LA20533_RS00580
uniprot id: A0A1L6XA99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1423721:LA20533 RS03145
gene id: 1423721:LA20533_RS03145
uniprot id: A0A0R1YQX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

1423721:LA20533 RS07750
gene id: 1423721:LA20533_RS07750
uniprot id: A0A0R1YPG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS07710
gene id: 1423721:LA20533_RS07710
uniprot id: A0A0R1YS15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1423721:LA20533 RS01655
gene id: 1423721:LA20533_RS01655
uniprot id: A0A0R1YIE8
names: Similarity
messages: Belongs to the UPF0297 family.

1423721:LA20533 RS05120
gene id: 1423721:LA20533_RS05120
uniprot id: A0A0R1YP23
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

1423721:LA20533 RS02450
gene id: 1423721:LA20533_RS02450
uniprot id: A0A1L6XB45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1423721:LA20533 RS06970
gene id: 1423721:LA20533_RS06970
uniprot id: A0A1L6XDE9
names: Similarity
messages: Belongs to the GSP E family.

1423721:LA20533 RS03760
gene id: 1423721:LA20533_RS03760
uniprot id: A0A0R1YKS5
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

1423721:LA20533 RS06205
gene id: 1423721:LA20533_RS06205
uniprot id: A0A0R1YRQ1
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

1423721:LA20533 RS07200
gene id: 1423721:LA20533_RS07200
uniprot id: A0A0R1YKH3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06890
gene id: 1423721:LA20533_RS06890
uniprot id: A0A0R1YJC2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1423721:LA20533 RS00730
gene id: 1423721:LA20533_RS00730
uniprot id: A0A0R1YLH9
names: Similarity
messages: Belongs to the TlyA family.

1423721:LA20533 RS05890
gene id: 1423721:LA20533_RS05890
uniprot id: A0A0R1YLI7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1423721:LA20533 RS07090
gene id: 1423721:LA20533_RS07090
uniprot id: A0A0R1YP33
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS01720
gene id: 1423721:LA20533_RS01720
uniprot id: A0A1L6XAT0
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS04165
gene id: 1423721:LA20533_RS04165
uniprot id: A0A0R1YV57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1423721:LA20533 RS05950
gene id: 1423721:LA20533_RS05950
uniprot id: A0A1L6XCY9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1423721:LA20533 RS01335
gene id: 1423721:LA20533_RS01335
uniprot id: A0A0R1YGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07990
gene id: 1423721:LA20533_RS07990
uniprot id: A0A1L6XEF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1423721:LA20533 RS02320
gene id: 1423721:LA20533_RS02320
uniprot id: A0A0R1YK22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

1423721:LA20533 RS05400
gene id: 1423721:LA20533_RS05400
uniprot id: A0A1L6XCM1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS04835
gene id: 1423721:LA20533_RS04835
uniprot id: A0A0R1YHI5
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07450
gene id: 1423721:LA20533_RS07450
uniprot id: A0A1L6XDR3
names: Similarity
messages: Belongs to the UPF0758 family.

1423721:LA20533 RS02350
gene id: 1423721:LA20533_RS02350
uniprot id: A0A1L6XB26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1423721:LA20533 RS07530
gene id: 1423721:LA20533_RS07530
uniprot id: A0A0R1YJM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1423721:LA20533 RS02805
gene id: 1423721:LA20533_RS02805
uniprot id: A0A0R1YN50
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1423721:LA20533 RS06195
gene id: 1423721:LA20533_RS06195
uniprot id: A0A0R1YJ84
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1423721:LA20533 RS04390
gene id: 1423721:LA20533_RS04390
uniprot id: A0A0R1YNX3
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1423721:LA20533 RS02925
gene id: 1423721:LA20533_RS02925
uniprot id: A0A0R1YJJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS02875
gene id: 1423721:LA20533_RS02875
uniprot id: A0A0R1YJ62
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

1423721:LA20533 RS05330
gene id: 1423721:LA20533_RS05330
uniprot id: A0A0R1YNF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1423721:LA20533 RS03300
gene id: 1423721:LA20533_RS03300
uniprot id: A0A0R1YMV2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

1423721:LA20533 RS06155
gene id: 1423721:LA20533_RS06155
uniprot id: A0A0R1YI71
names: Subcellular Location Annotation
messages: Cytoplasm

1423721:LA20533 RS00215
gene id: 1423721:LA20533_RS00215
uniprot id: A0A0R1YKV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1423721:LA20533 RS04170
gene id: 1423721:LA20533_RS04170
uniprot id: A0A1L6XC25
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02870
gene id: 1423721:LA20533_RS02870
uniprot id: A0A0R1YJC6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS01975
gene id: 1423721:LA20533_RS01975
uniprot id: A0A0R1YI23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1423721:LA20533 RS07955
gene id: 1423721:LA20533_RS07955
uniprot id: A0A0R1YJV7
names: Similarity
messages: Belongs to the DprA/Smf family.

1423721:LA20533 RS05765
gene id: 1423721:LA20533_RS05765
uniprot id: A0A0R1YRD9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1423721:LA20533 RS01235
gene id: 1423721:LA20533_RS01235
uniprot id: A0A0R1YHV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1423721:LA20533 RS00425
gene id: 1423721:LA20533_RS00425
uniprot id: A0A0R1YV16
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1423721:LA20533 RS05020
gene id: 1423721:LA20533_RS05020
uniprot id: A0A0R1YH79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1423721:LA20533 RS01995
gene id: 1423721:LA20533_RS01995
uniprot id: A0A0R1YJU6
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

1423721:LA20533 RS07695
gene id: 1423721:LA20533_RS07695
uniprot id: A0A1L6XDV3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05810
gene id: 1423721:LA20533_RS05810
uniprot id: A0A1L6XCV3
names: Similarity
messages: Belongs to the DCK/DGK family.

1423721:LA20533 RS00700
gene id: 1423721:LA20533_RS00700
uniprot id: A0A0R1YQ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1423721:LA20533 RS00860
gene id: 1423721:LA20533_RS00860
uniprot id: A0A1L6XAF4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1423721:LA20533 RS07490
gene id: 1423721:LA20533_RS07490
uniprot id: A0A0R1YJR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1423721:LA20533 RS08220
gene id: 1423721:LA20533_RS08220
uniprot id: A0A0R1YKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS02355
gene id: 1423721:LA20533_RS02355
uniprot id: A0A0R1YQF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1423721:LA20533 RS06785
gene id: 1423721:LA20533_RS06785
uniprot id: A0A0R1YRS0
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1423721:LA20533 RS06895
gene id: 1423721:LA20533_RS06895
uniprot id: A0A0R1YKH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1423721:LA20533 RS04755
gene id: 1423721:LA20533_RS04755
uniprot id: A0A0R1YGI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1423721:LA20533 RS05300
gene id: 1423721:LA20533_RS05300
uniprot id: A0A1L6XCK6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1423721:LA20533 RS03165
gene id: 1423721:LA20533_RS03165
uniprot id: A0A1L6XBJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1423721:LA20533 RS04965
gene id: 1423721:LA20533_RS04965
uniprot id: A0A1L6XCE9
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00160
gene id: 1423721:LA20533_RS00160
uniprot id: A0A0R1YK69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00415
gene id: 1423721:LA20533_RS00415
uniprot id: A0A0R1YLA6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS01150
gene id: 1423721:LA20533_RS01150
uniprot id: A0A0R1YHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1423721:LA20533 RS07460
gene id: 1423721:LA20533_RS07460
uniprot id: A0A0R1YRW5
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

1423721:LA20533 RS08240
gene id: 1423721:LA20533_RS08240
uniprot id: A0A0R1YLW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1423721:LA20533 RS05475
gene id: 1423721:LA20533_RS05475
uniprot id: A0A0R1YGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS06880
gene id: 1423721:LA20533_RS06880
uniprot id: A0A0R1YTX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1423721:LA20533 RS04125
gene id: 1423721:LA20533_RS04125
uniprot id: A0A0R1YMU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1423721:LA20533 RS05165
gene id: 1423721:LA20533_RS05165
uniprot id: A0A0R1YGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07500
gene id: 1423721:LA20533_RS07500
uniprot id: A0A0R1YKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS02510
gene id: 1423721:LA20533_RS02510
uniprot id: A0A0R1YJB1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1423721:LA20533 RS02455
gene id: 1423721:LA20533_RS02455
uniprot id: A0A0R1YIA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1423721:LA20533 RS05405
gene id: 1423721:LA20533_RS05405
uniprot id: A0A0R1YQI9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1423721:LA20533 RS00595
gene id: 1423721:LA20533_RS00595
uniprot id: A0A0R1YLI8
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1423721:LA20533 RS03075
gene id: 1423721:LA20533_RS03075
uniprot id: A0A0R1YID0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

1423721:LA20533 RS08265
gene id: 1423721:LA20533_RS08265
uniprot id: A0A0R1YL41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS00615
gene id: 1423721:LA20533_RS00615
uniprot id: A0A0R1YV82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1423721:LA20533 RS08035
gene id: 1423721:LA20533_RS08035
uniprot id: A0A0R1YJY0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00655
gene id: 1423721:LA20533_RS00655
uniprot id: A0A0R1YSQ1
names: Similarity
messages: Belongs to the asp23 family.

1423721:LA20533 RS06210
gene id: 1423721:LA20533_RS06210
uniprot id: A0A0R1YHZ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1423721:LA20533 RS06980
gene id: 1423721:LA20533_RS06980
uniprot id: A0A0R1YJG9
names: Function
messages: Required for transformation and DNA binding.

1423721:LA20533 RS08005
gene id: 1423721:LA20533_RS08005
uniprot id: A0A0R1YJX9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1423721:LA20533 RS01560
gene id: 1423721:LA20533_RS01560
uniprot id: A0A0R1YIX5
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1423721:LA20533 RS03765
gene id: 1423721:LA20533_RS03765
uniprot id: A0A0R1YLP2
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
messages: Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.

1423721:LA20533 RS02410
gene id: 1423721:LA20533_RS02410
uniprot id: A0A0R1YK29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS00585
gene id: 1423721:LA20533_RS00585
uniprot id: A0A1L6XAA6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1423721:LA20533 RS04940
gene id: 1423721:LA20533_RS04940
uniprot id: A0A0R1YH99
names: Similarity
messages: Belongs to the ParB family.

1423721:LA20533 RS01195
gene id: 1423721:LA20533_RS01195
uniprot id: A0A0R1YP70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS08150
gene id: 1423721:LA20533_RS08150
uniprot id: A0A0R1YUS3
names: Function
names: Similarity
messages: 3'-5' exonuclease.
messages: Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.

1423721:LA20533 RS03845
gene id: 1423721:LA20533_RS03845
uniprot id: A0A0R1YLM6
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07170
gene id: 1423721:LA20533_RS07170
uniprot id: A0A0R1YP49
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1423721:LA20533 RS03400
gene id: 1423721:LA20533_RS03400
uniprot id: A0A0R1YLU3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1423721:LA20533 RS06790
gene id: 1423721:LA20533_RS06790
uniprot id: A0A0R1YK81
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1423721:LA20533 RS04145
gene id: 1423721:LA20533_RS04145
uniprot id: A0A0R1YNS6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1423721:LA20533 RS00570
gene id: 1423721:LA20533_RS00570
uniprot id: A0A0R1YLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1423721:LA20533 RS07485
gene id: 1423721:LA20533_RS07485
uniprot id: A0A0R1YKS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1423721:LA20533 RS07385
gene id: 1423721:LA20533_RS07385
uniprot id: A0A0R1YU74
names: Similarity
messages: Belongs to the GcvH family.

1423721:LA20533 RS03195
gene id: 1423721:LA20533_RS03195
uniprot id: A0A0R1YM91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

1423721:LA20533 RS00985
gene id: 1423721:LA20533_RS00985
uniprot id: A0A1L6XAH5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1423721:LA20533 RS01885
gene id: 1423721:LA20533_RS01885
uniprot id: A0A0R1YJ44
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1423721:LA20533 RS02430
gene id: 1423721:LA20533_RS02430
uniprot id: A0A0R1YQQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS04410
gene id: 1423721:LA20533_RS04410
uniprot id: A0A0R1YVB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1423721:LA20533 RS02725
gene id: 1423721:LA20533_RS02725
uniprot id: A0A1L6XB92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1423721:LA20533 RS00375
gene id: 1423721:LA20533_RS00375
uniprot id: A0A0R1YKY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1423721:LA20533 RS08380
gene id: 1423721:LA20533_RS08380
uniprot id: A0A1L6XE70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1423721:LA20533 RS02335
gene id: 1423721:LA20533_RS02335
uniprot id: A0A0R1YIB2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1423721:LA20533 RS07160
gene id: 1423721:LA20533_RS07160
uniprot id: A0A0R1YK51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1423721:LA20533 RS07040
gene id: 1423721:LA20533_RS07040
uniprot id: A0A0R1YKD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS02435
gene id: 1423721:LA20533_RS02435
uniprot id: A0A0R1YJ90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1423721:LA20533 RS04450
gene id: 1423721:LA20533_RS04450
uniprot id: A0A0R1YMA8
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS01695
gene id: 1423721:LA20533_RS01695
uniprot id: A0A0R1YIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1423721:LA20533 RS08080
gene id: 1423721:LA20533_RS08080
uniprot id: A0A0R1YKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1423721:LA20533 RS05060
gene id: 1423721:LA20533_RS05060
uniprot id: A0A0R1YGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07830
gene id: 1423721:LA20533_RS07830
uniprot id: A0A0R1YLN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1423721:LA20533 RS02500
gene id: 1423721:LA20533_RS02500
uniprot id: A0A1L6XB69
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1423721:LA20533 RS06645
gene id: 1423721:LA20533_RS06645
uniprot id: A0A0R1YJ99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

1423721:LA20533 RS06190
gene id: 1423721:LA20533_RS06190
uniprot id: A0A0R1YQ24
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1423721:LA20533 RS05045
gene id: 1423721:LA20533_RS05045
uniprot id: A0A0R1YI38
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

1423721:LA20533 RS03275
gene id: 1423721:LA20533_RS03275
uniprot id: A0A1L6XBM4
names: Similarity
messages: Belongs to the PemK/MazF family.

1423721:LA20533 RS08000
gene id: 1423721:LA20533_RS08000
uniprot id: A0A0R1YKD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1423721:LA20533 RS01615
gene id: 1423721:LA20533_RS01615
uniprot id: A0A0R1YIS0
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1423721:LA20533 RS08205
gene id: 1423721:LA20533_RS08205
uniprot id: A0A0R1YK44
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00350
gene id: 1423721:LA20533_RS00350
uniprot id: A0A1L6XA54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1423721:LA20533 RS04140
gene id: 1423721:LA20533_RS04140
uniprot id: A0A1L6XBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1423721:LA20533 RS03185
gene id: 1423721:LA20533_RS03185
uniprot id: A0A1L6XBI1
names: Similarity
messages: Belongs to the asparagine synthetase family.

1423721:LA20533 RS02935
gene id: 1423721:LA20533_RS02935
uniprot id: A0A0R1YT03
names: Caution
names: Similarity
messages: Belongs to the peptidase C40 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS08155
gene id: 1423721:LA20533_RS08155
uniprot id: A0A0R1YPP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

1423721:LA20533 RS07620
gene id: 1423721:LA20533_RS07620
uniprot id: A0A0R1YSB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1423721:LA20533 RS07685
gene id: 1423721:LA20533_RS07685
uniprot id: A0A0R1YSE7
names: Similarity
messages: Belongs to the peptidase S16 family.

1423721:LA20533 RS05015
gene id: 1423721:LA20533_RS05015
uniprot id: A0A1L6XCF7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS03235
gene id: 1423721:LA20533_RS03235
uniprot id: A0A1L6XBH8
names: Similarity
messages: Belongs to the universal stress protein A family.

1423721:LA20533 RS00390
gene id: 1423721:LA20533_RS00390
uniprot id: A0A0R1YM23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS07725
gene id: 1423721:LA20533_RS07725
uniprot id: A0A0R1YJR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1423721:LA20533 RS06355
gene id: 1423721:LA20533_RS06355
uniprot id: A0A0R1YJI1
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1423721:LA20533 RS04775
gene id: 1423721:LA20533_RS04775
uniprot id: A0A1L6XCB8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

1423721:LA20533 RS02565
gene id: 1423721:LA20533_RS02565
uniprot id: A0A0R1YSR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1423721:LA20533 RS04710
gene id: 1423721:LA20533_RS04710
uniprot id: A0A0R1YMD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS01745
gene id: 1423721:LA20533_RS01745
uniprot id: A0A0R1YMJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1423721:LA20533 RS08030
gene id: 1423721:LA20533_RS08030
uniprot id: A0A0R1YKS7
names: Similarity
messages: Belongs to the CarB family.

1423721:LA20533 RS07745
gene id: 1423721:LA20533_RS07745
uniprot id: A0A0R1YUG1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1423721:LA20533 RS00065
gene id: 1423721:LA20533_RS00065
uniprot id: A0A0R1YSQ7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

1423721:LA20533 RS01805
gene id: 1423721:LA20533_RS01805
uniprot id: A0A0R1YHY4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1423721:LA20533 RS06925
gene id: 1423721:LA20533_RS06925
uniprot id: A0A0R1YL64
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1423721:LA20533 RS04185
gene id: 1423721:LA20533_RS04185
uniprot id: A0A0R1YMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04195
gene id: 1423721:LA20533_RS04195
uniprot id: A0A0R1YN75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS02085
gene id: 1423721:LA20533_RS02085
uniprot id: A0A0R1YQQ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1423721:LA20533 RS01900
gene id: 1423721:LA20533_RS01900
uniprot id: A0A0R1YIT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

1423721:LA20533 RS07330
gene id: 1423721:LA20533_RS07330
uniprot id: A0A0R1YK85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1423721:LA20533 RS04060
gene id: 1423721:LA20533_RS04060
uniprot id: A0A0R1YH22
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1423721:LA20533 RS07535
gene id: 1423721:LA20533_RS07535
uniprot id: A0A0R1YS89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1423721:LA20533 RS00495
gene id: 1423721:LA20533_RS00495
uniprot id: A0A0R1YLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS06720
gene id: 1423721:LA20533_RS06720
uniprot id: A0A0R1YKD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1423721:LA20533 RS00130
gene id: 1423721:LA20533_RS00130
uniprot id: A0A0R1YUW0
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

1423721:LA20533 RS06165
gene id: 1423721:LA20533_RS06165
uniprot id: A0A0R1YPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS05380
gene id: 1423721:LA20533_RS05380
uniprot id: A0A0R1YGY0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1423721:LA20533 RS02995
gene id: 1423721:LA20533_RS02995
uniprot id: A0A0R1YIN1
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

1423721:LA20533 RS06755
gene id: 1423721:LA20533_RS06755
uniprot id: A0A0R1YRU4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

1423721:LA20533 RS06810
gene id: 1423721:LA20533_RS06810
uniprot id: A0A0R1YJB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1423721:LA20533 RS02525
gene id: 1423721:LA20533_RS02525
uniprot id: A0A1L6XE94
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS02530
gene id: 1423721:LA20533_RS02530
uniprot id: A0A0R1YSQ6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1423721:LA20533 RS03050
gene id: 1423721:LA20533_RS03050
uniprot id: A0A0R1YRV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1423721:LA20533 RS07590
gene id: 1423721:LA20533_RS07590
uniprot id: A0A1L6XDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

1423721:LA20533 RS00855
gene id: 1423721:LA20533_RS00855
uniprot id: A0A0R1YL88
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1423721:LA20533 RS00335
gene id: 1423721:LA20533_RS00335
uniprot id: A0A0R1YL94
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1423721:LA20533 RS07345
gene id: 1423721:LA20533_RS07345
uniprot id: A0A0R1YLD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1423721:LA20533 RS02860
gene id: 1423721:LA20533_RS02860
uniprot id: A0A0R1YJP2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS04370
gene id: 1423721:LA20533_RS04370
uniprot id: A0A0R1YMY4
names: Similarity
messages: Belongs to the peptidase M20A family.

1423721:LA20533 RS00315
gene id: 1423721:LA20533_RS00315
uniprot id: A0A0R1YSU7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1423721:LA20533 RS06640
gene id: 1423721:LA20533_RS06640
uniprot id: A0A0R1YKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

1423721:LA20533 RS02480
gene id: 1423721:LA20533_RS02480
uniprot id: A0A0R1YMY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1423721:LA20533 RS02125
gene id: 1423721:LA20533_RS02125
uniprot id: A0A0R1YJ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1423721:LA20533 RS04500
gene id: 1423721:LA20533_RS04500
uniprot id: A0A0R1YMA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07920
gene id: 1423721:LA20533_RS07920
uniprot id: A0A0R1YKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1423721:LA20533 RS04915
gene id: 1423721:LA20533_RS04915
uniprot id: A0A0R1YHG9
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS08280
gene id: 1423721:LA20533_RS08280
uniprot id: A0A0R1YKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS03790
gene id: 1423721:LA20533_RS03790
uniprot id: A0A0R1YKW5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

1423721:LA20533 RS06305
gene id: 1423721:LA20533_RS06305
uniprot id: A0A0R1YJR6
names: Similarity
messages: Belongs to the peptidase M29 family.

1423721:LA20533 RS00090
gene id: 1423721:LA20533_RS00090
uniprot id: A0A1L6XA15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS06625
gene id: 1423721:LA20533_RS06625
uniprot id: A0A0R1YTR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1423721:LA20533 RS06160
gene id: 1423721:LA20533_RS06160
uniprot id: A0A1L6XD05
names: Similarity
messages: Belongs to the glycosyl hydrolase 73 family.

1423721:LA20533 RS02385
gene id: 1423721:LA20533_RS02385
uniprot id: A0A1L6XB46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1423721:LA20533 RS05865
gene id: 1423721:LA20533_RS05865
uniprot id: A0A0R1YUT4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1423721:LA20533 RS07930
gene id: 1423721:LA20533_RS07930
uniprot id: A0A0R1YSJ9
names: Similarity
messages: Belongs to the UPF0346 family.

1423721:LA20533 RS01205
gene id: 1423721:LA20533_RS01205
uniprot id: A0A0R1YP11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04330
gene id: 1423721:LA20533_RS04330
uniprot id: A0A1L6XC30
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00410
gene id: 1423721:LA20533_RS00410
uniprot id: A0A0R1YSW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1423721:LA20533 RS00385
gene id: 1423721:LA20533_RS00385
uniprot id: A0A0R1YPX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1423721:LA20533 RS07845
gene id: 1423721:LA20533_RS07845
uniprot id: A0A0R1YJU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

1423721:LA20533 RS00765
gene id: 1423721:LA20533_RS00765
uniprot id: A0A0R1YLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1423721:LA20533 RS03380
gene id: 1423721:LA20533_RS03380
uniprot id: A0A0R1YTS3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03785
gene id: 1423721:LA20533_RS03785
uniprot id: A0A0R1YTJ6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS07625
gene id: 1423721:LA20533_RS07625
uniprot id: A0A0R1YKQ3
names: Function
names: Similarity
names: Subunit
messages: A non-essential component of RNA polymerase (RNAP).
messages: Belongs to the RNA polymerase subunit epsilon family.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1423721:LA20533 RS02305
gene id: 1423721:LA20533_RS02305
uniprot id: A0A0R1YIT8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS08335
gene id: 1423721:LA20533_RS08335
uniprot id: A0A0R1YST8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS06600
gene id: 1423721:LA20533_RS06600
uniprot id: A0A0R1YJM5
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05625
gene id: 1423721:LA20533_RS05625
uniprot id: A0A0R1YWY8
names: Similarity
messages: Belongs to the plasmid replication initiation factor family.

1423721:LA20533 RS08275
gene id: 1423721:LA20533_RS08275
uniprot id: A0A0R1YUU0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1423721:LA20533 RS07280
gene id: 1423721:LA20533_RS07280
uniprot id: A0A0R1YJH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1423721:LA20533 RS07405
gene id: 1423721:LA20533_RS07405
uniprot id: A0A0R1YJQ1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1423721:LA20533 RS04665
gene id: 1423721:LA20533_RS04665
uniprot id: A0A1L6XC91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1423721:LA20533 RS07095
gene id: 1423721:LA20533_RS07095
uniprot id: A0A0R1YL91
names: Function
names: Similarity
messages: Belongs to the CpsD/CapB family.
messages: Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide.

1423721:LA20533 RS02460
gene id: 1423721:LA20533_RS02460
uniprot id: A0A0R1YJG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS00210
gene id: 1423721:LA20533_RS00210
uniprot id: A0A1L6XE70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1423721:LA20533 RS04245
gene id: 1423721:LA20533_RS04245
uniprot id: A0A0R1YV79
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS01625
gene id: 1423721:LA20533_RS01625
uniprot id: A0A0R1YS55
names: Similarity
messages: Belongs to the thioredoxin family.

1423721:LA20533 RS07980
gene id: 1423721:LA20533_RS07980
uniprot id: A0A0R1YUM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1423721:LA20533 RS03720
gene id: 1423721:LA20533_RS03720
uniprot id: A0A0R1YLB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS04155
gene id: 1423721:LA20533_RS04155
uniprot id: A0A0R1YMI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.

1423721:LA20533 RS00890
gene id: 1423721:LA20533_RS00890
uniprot id: A0A0R1YKK8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS01020
gene id: 1423721:LA20533_RS01020
uniprot id: A0A1L6XAH8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1423721:LA20533 RS08330
gene id: 1423721:LA20533_RS08330
uniprot id: A0A0R1YK69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS01770
gene id: 1423721:LA20533_RS01770
uniprot id: A0A0R1YQD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: chloroplast

1423721:LA20533 RS02370
gene id: 1423721:LA20533_RS02370
uniprot id: A0A0R1YI93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS06360
gene id: 1423721:LA20533_RS06360
uniprot id: A0A0R1YJ21
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1423721:LA20533 RS00810
gene id: 1423721:LA20533_RS00810
uniprot id: A0A0R1YT53
names: Similarity
messages: Belongs to the glutamine synthetase family.

1423721:LA20533 RS05435
gene id: 1423721:LA20533_RS05435
uniprot id: A0A0R1YNW8
names: Similarity
messages: Belongs to the peptidase C40 family.

1423721:LA20533 RS06635
gene id: 1423721:LA20533_RS06635
uniprot id: A0A0R1YJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

1423721:LA20533 RS07645
gene id: 1423721:LA20533_RS07645
uniprot id: A0A0R1YJP5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1423721:LA20533 RS08260
gene id: 1423721:LA20533_RS08260
uniprot id: A0A0R1YSS7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1423721:LA20533 RS00605
gene id: 1423721:LA20533_RS00605
uniprot id: A0A0R1YL82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1423721:LA20533 RS05090
gene id: 1423721:LA20533_RS05090
uniprot id: A0A0R1YQP1
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1423721:LA20533 RS01025
gene id: 1423721:LA20533_RS01025
uniprot id: A0A0R1YH15
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1423721:LA20533 RS03260
gene id: 1423721:LA20533_RS03260
uniprot id: A0A0R1YLZ1
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06260
gene id: 1423721:LA20533_RS06260
uniprot id: A0A0R1YKT3
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS03480
gene id: 1423721:LA20533_RS03480
uniprot id: A0A0R1YLS3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1423721:LA20533 RS06805
gene id: 1423721:LA20533_RS06805
uniprot id: A0A0R1YK28
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1423721:LA20533 RS07420
gene id: 1423721:LA20533_RS07420
uniprot id: A0A0R1YU76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EzrA family.
messages: Cell membrane
messages: Membrane
messages: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

1423721:LA20533 RS00270
gene id: 1423721:LA20533_RS00270
uniprot id: A0A0R1YK88
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1423721:LA20533 RS08140
gene id: 1423721:LA20533_RS08140
uniprot id: A0A1L6XEF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS03255
gene id: 1423721:LA20533_RS03255
uniprot id: A0A0R1YL07
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00220
gene id: 1423721:LA20533_RS00220
uniprot id: A0A0R1YUY3
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1423721:LA20533 RS04990
gene id: 1423721:LA20533_RS04990
uniprot id: A0A0R1YGC8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS05185
gene id: 1423721:LA20533_RS05185
uniprot id: A0A0R1YNI7
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07900
gene id: 1423721:LA20533_RS07900
uniprot id: A0A0R1YUK1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1423721:LA20533 RS03940
gene id: 1423721:LA20533_RS03940
uniprot id: A0A1L6XBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1423721:LA20533 RS03740
gene id: 1423721:LA20533_RS03740
uniprot id: A0A0R1YLL8
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1423721:LA20533 RS04385
gene id: 1423721:LA20533_RS04385
uniprot id: A0A0R1YRX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS00340
gene id: 1423721:LA20533_RS00340
uniprot id: A0A0R1YSI3
names: Similarity
messages: Belongs to the ribF family.

1423721:LA20533 RS03780
gene id: 1423721:LA20533_RS03780
uniprot id: A0A0R1YLW7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1423721:LA20533 RS06910
gene id: 1423721:LA20533_RS06910
uniprot id: A0A1L6XED3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS05125
gene id: 1423721:LA20533_RS05125
uniprot id: A0A0R1YI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

1423721:LA20533 RS06740
gene id: 1423721:LA20533_RS06740
uniprot id: A0A0R1YTS5
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1423721:LA20533 RS04790
gene id: 1423721:LA20533_RS04790
uniprot id: A0A0R1YGH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1423721:LA20533 RS03615
gene id: 1423721:LA20533_RS03615
uniprot id: A0A0R1YVT8
names: Similarity
messages: Belongs to the plasmid replication initiation factor family.

1423721:LA20533 RS03685
gene id: 1423721:LA20533_RS03685
uniprot id: A0A0R1YKU1
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05855
gene id: 1423721:LA20533_RS05855
uniprot id: A0A0R1YUI6
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1423721:LA20533 RS07770
gene id: 1423721:LA20533_RS07770
uniprot id: A0A0R1YSF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS06090
gene id: 1423721:LA20533_RS06090
uniprot id: A0A0R1YHK2
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07515
gene id: 1423721:LA20533_RS07515
uniprot id: A0A0R1YLG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS04545
gene id: 1423721:LA20533_RS04545
uniprot id: A0A0R1YN14
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00610
gene id: 1423721:LA20533_RS00610
uniprot id: A0A0R1YL40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1423721:LA20533 RS04610
gene id: 1423721:LA20533_RS04610
uniprot id: A0A0R1YL68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS08110
gene id: 1423721:LA20533_RS08110
uniprot id: A0A0R1YSA1
names: Subcellular Location Annotation
messages: Cytoplasm

1423721:LA20533 RS00465
gene id: 1423721:LA20533_RS00465
uniprot id: A0A0R1YV39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1423721:LA20533 RS04260
gene id: 1423721:LA20533_RS04260
uniprot id: A0A1L6XC16
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS07285
gene id: 1423721:LA20533_RS07285
uniprot id: A0A0R1YS30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1423721:LA20533 RS06655
gene id: 1423721:LA20533_RS06655
uniprot id: A0A0R1YJW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1423721:LA20533 RS00785
gene id: 1423721:LA20533_RS00785
uniprot id: A0A0R1YM98
names: Similarity
messages: Belongs to the EamA transporter family.

1423721:LA20533 RS05370
gene id: 1423721:LA20533_RS05370
uniprot id: A0A0R1YQH5
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

1423721:LA20533 RS00245
gene id: 1423721:LA20533_RS00245
uniprot id: A0A0R1YK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1423721:LA20533 RS06445
gene id: 1423721:LA20533_RS06445
uniprot id: A0A1L6XD55
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1423721:LA20533 RS06440
gene id: 1423721:LA20533_RS06440
uniprot id: A0A0R1YJJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1423721:LA20533 RS00575
gene id: 1423721:LA20533_RS00575
uniprot id: A0A0R1YSP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1423721:LA20533 RS01705
gene id: 1423721:LA20533_RS01705
uniprot id: A0A0R1YS76
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1423721:LA20533 RS03435
gene id: 1423721:LA20533_RS03435
uniprot id: A0A0R1YTD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1423721:LA20533 RS04635
gene id: 1423721:LA20533_RS04635
uniprot id: A0A0R1YU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1423721:LA20533 RS04375
gene id: 1423721:LA20533_RS04375
uniprot id: A0A0R1YMX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

1423721:LA20533 RS03420
gene id: 1423721:LA20533_RS03420
uniprot id: A0A0R1YKY3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02380
gene id: 1423721:LA20533_RS02380
uniprot id: A0A0R1YIA3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1423721:LA20533 RS01550
gene id: 1423721:LA20533_RS01550
uniprot id: A0A1L6XAP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

1423721:LA20533 RS07320
gene id: 1423721:LA20533_RS07320
uniprot id: A0A0R1YJN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1423721:LA20533 RS00760
gene id: 1423721:LA20533_RS00760
uniprot id: A0A0R1YKJ4
names: Similarity
messages: Belongs to the asp23 family.

1423721:LA20533 RS02960
gene id: 1423721:LA20533_RS02960
uniprot id: A0A0R1YJE1
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1423721:LA20533 RS01050
gene id: 1423721:LA20533_RS01050
uniprot id: A0A0R1YQZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1423721:LA20533 RS00590
gene id: 1423721:LA20533_RS00590
uniprot id: A0A0R1YKE6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1423721:LA20533 RS03230
gene id: 1423721:LA20533_RS03230
uniprot id: A0A0R1YW29
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1423721:LA20533 RS03930
gene id: 1423721:LA20533_RS03930
uniprot id: A0A1L6XBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1423721:LA20533 RS05190
gene id: 1423721:LA20533_RS05190
uniprot id: A0A0R1YH42
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06540
gene id: 1423721:LA20533_RS06540
uniprot id: A0A1L6XD89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00320
gene id: 1423721:LA20533_RS00320
uniprot id: A0A0R1YKN1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1423721:LA20533 RS05140
gene id: 1423721:LA20533_RS05140
uniprot id: A0A0R1YQM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1423721:LA20533 RS00405
gene id: 1423721:LA20533_RS00405
uniprot id: A0A0R1YKB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1423721:LA20533 RS07855
gene id: 1423721:LA20533_RS07855
uniprot id: A0A0R1YKV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

1423721:LA20533 RS01815
gene id: 1423721:LA20533_RS01815
uniprot id: A0A0R1YIH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1423721:LA20533 RS02415
gene id: 1423721:LA20533_RS02415
uniprot id: A0A0R1YQV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1423721:LA20533 RS07045
gene id: 1423721:LA20533_RS07045
uniprot id: A0A0R1YRM6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1423721:LA20533 RS06715
gene id: 1423721:LA20533_RS06715
uniprot id: A0A0R1YJ91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1423721:LA20533 RS07295
gene id: 1423721:LA20533_RS07295
uniprot id: A0A0R1YRS2
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1423721:LA20533 RS01910
gene id: 1423721:LA20533_RS01910
uniprot id: A0A0R1YSC1
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1423721:LA20533 RS04425
gene id: 1423721:LA20533_RS04425
uniprot id: A0A0R1YX96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

1423721:LA20533 RS07665
gene id: 1423721:LA20533_RS07665
uniprot id: A0A0R1YKF3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05960
gene id: 1423721:LA20533_RS05960
uniprot id: A0A0R1YWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS08245
gene id: 1423721:LA20533_RS08245
uniprot id: A0A0R1YSQ7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

1423721:LA20533 RS07165
gene id: 1423721:LA20533_RS07165
uniprot id: A0A0R1YU19
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1423721:LA20533 RS00660
gene id: 1423721:LA20533_RS00660
uniprot id: A0A0R1YV73
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1423721:LA20533 RS02440
gene id: 1423721:LA20533_RS02440
uniprot id: A0A0R1YQH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1423721:LA20533 RS01945
gene id: 1423721:LA20533_RS01945
uniprot id: A0A0R1YIY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

1423721:LA20533 RS05195
gene id: 1423721:LA20533_RS05195
uniprot id: A0A0R1YNQ5
names: Subcellular Location Annotation
messages: Cytoplasm

1423721:LA20533 RS04225
gene id: 1423721:LA20533_RS04225
uniprot id: A0A0R1YNU1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1423721:LA20533 RS05515
gene id: 1423721:LA20533_RS05515
uniprot id: A0A0R1YKR2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1423721:LA20533 RS01680
gene id: 1423721:LA20533_RS01680
uniprot id: A0A1L6XAS2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS03425
gene id: 1423721:LA20533_RS03425
uniprot id: A0A1L6XE95
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07910
gene id: 1423721:LA20533_RS07910
uniprot id: A0A1L6XEE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS01730
gene id: 1423721:LA20533_RS01730
uniprot id: A0A0R1YIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1423721:LA20533 RS03000
gene id: 1423721:LA20533_RS03000
uniprot id: A0A0R1YR14
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1423721:LA20533 RS03160
gene id: 1423721:LA20533_RS03160
uniprot id: A0A0R1YLZ9
names: Similarity
names: Subunit
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Homotetramer.

1423721:LA20533 RS07875
gene id: 1423721:LA20533_RS07875
uniprot id: A0A0R1YJU2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1423721:LA20533 RS02830
gene id: 1423721:LA20533_RS02830
uniprot id: A0A1L6XBA7
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1423721:LA20533 RS00840
gene id: 1423721:LA20533_RS00840
uniprot id: A0A0R1YLN6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1423721:LA20533 RS06545
gene id: 1423721:LA20533_RS06545
uniprot id: A0A0R1YTP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1423721:LA20533 RS04275
gene id: 1423721:LA20533_RS04275
uniprot id: A0A0R1YLS5
names: Similarity
messages: Belongs to the UPF0177 family.

1423721:LA20533 RS04920
gene id: 1423721:LA20533_RS04920
uniprot id: A0A0R1YGE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS03505
gene id: 1423721:LA20533_RS03505
uniprot id: A0A0R1YKW7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1423721:LA20533 RS04760
gene id: 1423721:LA20533_RS04760
uniprot id: A0A0R1YH54
names: Similarity
messages: Belongs to the XFP family.

1423721:LA20533 RS07415
gene id: 1423721:LA20533_RS07415
uniprot id: A0A1L6XDN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1423721:LA20533 RS07815
gene id: 1423721:LA20533_RS07815
uniprot id: A0A0R1YKI2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS03330
gene id: 1423721:LA20533_RS03330
uniprot id: A0A0R1YM85
names: Similarity
messages: Belongs to the TPP enzyme family.

1423721:LA20533 RS08185
gene id: 1423721:LA20533_RS08185
uniprot id: A0A0R1YL23
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03025
gene id: 1423721:LA20533_RS03025
uniprot id: A0A1L6XBD3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02420
gene id: 1423721:LA20533_RS02420
uniprot id: A0A0R1YIQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1423721:LA20533 RS02535
gene id: 1423721:LA20533_RS02535
uniprot id: A0A0R1YJ35
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

1423721:LA20533 RS01810
gene id: 1423721:LA20533_RS01810
uniprot id: A0A0R1YIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1423721:LA20533 RS04135
gene id: 1423721:LA20533_RS04135
uniprot id: A0A0R1YX51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1423721:LA20533 RS00125
gene id: 1423721:LA20533_RS00125
uniprot id: A0A0R1YKT4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1423721:LA20533 RS07315
gene id: 1423721:LA20533_RS07315
uniprot id: A0A0R1YKP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1423721:LA20533 RS02820
gene id: 1423721:LA20533_RS02820
uniprot id: A0A0R1YIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.
messages: Membrane

1423721:LA20533 RS07300
gene id: 1423721:LA20533_RS07300
uniprot id: A0A0R1YU57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1423721:LA20533 RS04725
gene id: 1423721:LA20533_RS04725
uniprot id: A0A0R1YLQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1423721:LA20533 RS06435
gene id: 1423721:LA20533_RS06435
uniprot id: A0A0R1YRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
messages: P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity.

1423721:LA20533 RS06480
gene id: 1423721:LA20533_RS06480
uniprot id: A0A1L6XD60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArsC family. Spx subfamily.
messages: Cytoplasm
messages: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
messages: Interacts with the C-terminal domain of the alpha subunit of the RNAP.

1423721:LA20533 RS00725
gene id: 1423721:LA20533_RS00725
uniprot id: A0A0R1YT37
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1423721:LA20533 RS04895
gene id: 1423721:LA20533_RS04895
uniprot id: A0A0R1YL37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1423721:LA20533 RS08885
gene id: 1423721:LA20533_RS08885
uniprot id: A0A0R1YT58
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1423721:LA20533 RS02195
gene id: 1423721:LA20533_RS02195
uniprot id: A0A0R1YIX0
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1423721:LA20533 RS06820
gene id: 1423721:LA20533_RS06820
uniprot id: A0A0R1YJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1423721:LA20533 RS07995
gene id: 1423721:LA20533_RS07995
uniprot id: A0A1L6XE16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1423721:LA20533 RS00640
gene id: 1423721:LA20533_RS00640
uniprot id: A0A0R1YKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1423721:LA20533 RS06095
gene id: 1423721:LA20533_RS06095
uniprot id: A0A1L6XCZ9
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

1423721:LA20533 RS05390
gene id: 1423721:LA20533_RS05390
uniprot id: A0A0R1YH52
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS07820
gene id: 1423721:LA20533_RS07820
uniprot id: A0A0R1YUI1
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1423721:LA20533 RS00910
gene id: 1423721:LA20533_RS00910
uniprot id: A0A0R1YVC6
names: Similarity
messages: Belongs to the acylphosphatase family.

1423721:LA20533 RS00085
gene id: 1423721:LA20533_RS00085
uniprot id: A0A0R1YL41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1423721:LA20533 RS05970
gene id: 1423721:LA20533_RS05970
uniprot id: A0A1L6XCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1423721:LA20533 RS02970
gene id: 1423721:LA20533_RS02970
uniprot id: A0A0R1YSY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

1423721:LA20533 RS06340
gene id: 1423721:LA20533_RS06340
uniprot id: A0A1L6XED6
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1423721:LA20533 RS07540
gene id: 1423721:LA20533_RS07540
uniprot id: A0A1L6XDQ5
names: Similarity
messages: Belongs to the YggT family.

1423721:LA20533 RS01280
gene id: 1423721:LA20533_RS01280
uniprot id: A0A0R1YH61
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1423721:LA20533 RS02315
gene id: 1423721:LA20533_RS02315
uniprot id: A0A0R1YMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

1423721:LA20533 RS04085
gene id: 1423721:LA20533_RS04085
uniprot id: A0A0R1YV36
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1423721:LA20533 RS03305
gene id: 1423721:LA20533_RS03305
uniprot id: A0A0R1YQT7
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1423721:LA20533 RS08045
gene id: 1423721:LA20533_RS08045
uniprot id: A0A0R1YK33
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1423721:LA20533 RS05895
gene id: 1423721:LA20533_RS05895
uniprot id: A0A0R1YMX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1423721:LA20533 RS03450
gene id: 1423721:LA20533_RS03450
uniprot id: A0A1L6XBQ7
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS07715
gene id: 1423721:LA20533_RS07715
uniprot id: A0A0R1YUF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00635
gene id: 1423721:LA20533_RS00635
uniprot id: A0A0R1YKV5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1423721:LA20533 RS05705
gene id: 1423721:LA20533_RS05705
uniprot id: A0A0R1YH03
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

1423721:LA20533 RS04950
gene id: 1423721:LA20533_RS04950
uniprot id: A0A0R1YGE7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1423721:LA20533 RS00100
gene id: 1423721:LA20533_RS00100
uniprot id: A0A0R1YKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS02340
gene id: 1423721:LA20533_RS02340
uniprot id: A0A0R1YQN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1423721:LA20533 RS07290
gene id: 1423721:LA20533_RS07290
uniprot id: A0A0R1YKJ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1423721:LA20533 RS00500
gene id: 1423721:LA20533_RS00500
uniprot id: A0A0R1YSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

1423721:LA20533 RS07245
gene id: 1423721:LA20533_RS07245
uniprot id: A0A0R1YU39
names: Similarity
messages: Belongs to the UPF0111 family.

1423721:LA20533 RS01735
gene id: 1423721:LA20533_RS01735
uniprot id: A0A0R1YIG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1423721:LA20533 RS05730
gene id: 1423721:LA20533_RS05730
uniprot id: A0A0R1YMH4
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family.

1423721:LA20533 RS05575
gene id: 1423721:LA20533_RS05575
uniprot id: A0A0R1YQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C40 family.
messages: Cell surface

1423721:LA20533 RS02425
gene id: 1423721:LA20533_RS02425
uniprot id: A0A0R1YIC8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1423721:LA20533 RS02505
gene id: 1423721:LA20533_RS02505
uniprot id: A0A0R1YQS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1423721:LA20533 RS03405
gene id: 1423721:LA20533_RS03405
uniprot id: A0A0R1YLW2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1423721:LA20533 RS02705
gene id: 1423721:LA20533_RS02705
uniprot id: A0A0R1YIH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00510
gene id: 1423721:LA20533_RS00510
uniprot id: A0A0R1YL54
names: Similarity
messages: Belongs to the Dps family.

1423721:LA20533 RS05145
gene id: 1423721:LA20533_RS05145
uniprot id: A0A1L6XCH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

1423721:LA20533 RS07765
gene id: 1423721:LA20533_RS07765
uniprot id: A0A1L6XDV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0213 family.
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1423721:LA20533 RS03285
gene id: 1423721:LA20533_RS03285
uniprot id: A0A0R1YTY2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1423721:LA20533 RS01540
gene id: 1423721:LA20533_RS01540
uniprot id: A0A0R1YQ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07395
gene id: 1423721:LA20533_RS07395
uniprot id: A0A0R1YJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

1423721:LA20533 RS07785
gene id: 1423721:LA20533_RS07785
uniprot id: A0A0R1YUH1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1423721:LA20533 RS03150
gene id: 1423721:LA20533_RS03150
uniprot id: A0A0R1YW40
names: Similarity
messages: Belongs to the universal stress protein A family.

1423721:LA20533 RS01675
gene id: 1423721:LA20533_RS01675
uniprot id: A0A1L6XE78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1423721:LA20533 RS07595
gene id: 1423721:LA20533_RS07595
uniprot id: A0A0R1YPC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cell envelope
messages: Releases the N-terminal proline from various substrates.

1423721:LA20533 RS00325
gene id: 1423721:LA20533_RS00325
uniprot id: A0A0R1YK97
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1423721:LA20533 RS06870
gene id: 1423721:LA20533_RS06870
uniprot id: A0A0R1YK98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1423721:LA20533 RS03220
gene id: 1423721:LA20533_RS03220
uniprot id: A0A0R1YMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04620
gene id: 1423721:LA20533_RS04620
uniprot id: A0A0R1YW91
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1423721:LA20533 RS04430
gene id: 1423721:LA20533_RS04430
uniprot id: A0A0R1YMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07740
gene id: 1423721:LA20533_RS07740
uniprot id: A0A0R1YKG4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1423721:LA20533 RS04695
gene id: 1423721:LA20533_RS04695
uniprot id: A0A1L6XCA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1423721:LA20533 RS00965
gene id: 1423721:LA20533_RS00965
uniprot id: A0A0R1YHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm

1423721:LA20533 RS01055
gene id: 1423721:LA20533_RS01055
uniprot id: A0A0R1YHA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1423721:LA20533 RS00435
gene id: 1423721:LA20533_RS00435
uniprot id: A0A0R1YKC2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

1423721:LA20533 RS03655
gene id: 1423721:LA20533_RS03655
uniprot id: A0A0R1YQL9
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1423721:LA20533 RS07465
gene id: 1423721:LA20533_RS07465
uniprot id: A0A0R1YU95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

1423721:LA20533 RS01645
gene id: 1423721:LA20533_RS01645
uniprot id: A0A0R1YHV1
names: Similarity
messages: Belongs to the UPF0473 family.

1423721:LA20533 RS02625
gene id: 1423721:LA20533_RS02625
uniprot id: A0A0R1YJJ0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1423721:LA20533 RS04780
gene id: 1423721:LA20533_RS04780
uniprot id: A0A0R1YHC6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1423721:LA20533 RS02660
gene id: 1423721:LA20533_RS02660
uniprot id: A0A0R1YIV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RpoE family.
messages: Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors.

1423721:LA20533 RS02485
gene id: 1423721:LA20533_RS02485
uniprot id: A0A0R1YK50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1423721:LA20533 RS08305
gene id: 1423721:LA20533_RS08305
uniprot id: A0A0R1YKT4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1423721:LA20533 RS00060
gene id: 1423721:LA20533_RS00060
uniprot id: A0A0R1YLW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

1423721:LA20533 RS07335
gene id: 1423721:LA20533_RS07335
uniprot id: A0A0R1YU56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1423721:LA20533 RS06675
gene id: 1423721:LA20533_RS06675
uniprot id: A0A0R1YRS9
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS04110
gene id: 1423721:LA20533_RS04110
uniprot id: A0A0R1YLQ2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1423721:LA20533 RS01090
gene id: 1423721:LA20533_RS01090
uniprot id: A0A0R1YIH4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

1423721:LA20533 RS01690
gene id: 1423721:LA20533_RS01690
uniprot id: A0A0R1YQA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1423721:LA20533 RS07650
gene id: 1423721:LA20533_RS07650
uniprot id: A0A0R1YKV6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1423721:LA20533 RS07895
gene id: 1423721:LA20533_RS07895
uniprot id: A0A0R1YKJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07205
gene id: 1423721:LA20533_RS07205
uniprot id: A0A0R1YRR0
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02090
gene id: 1423721:LA20533_RS02090
uniprot id: A0A0R1YII0
names: Similarity
messages: Belongs to the TPP enzyme family.

1423721:LA20533 RS06410
gene id: 1423721:LA20533_RS06410
uniprot id: A0A0R1YJV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

1423721:LA20533 RS06875
gene id: 1423721:LA20533_RS06875
uniprot id: A0A1L6XDD7
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1423721:LA20533 RS00145
gene id: 1423721:LA20533_RS00145
uniprot id: A0A0R1YLX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS08365
gene id: 1423721:LA20533_RS08365
uniprot id: A0A0R1YK73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS08040
gene id: 1423721:LA20533_RS08040
uniprot id: A0A0R1YL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1423721:LA20533 RS00355
gene id: 1423721:LA20533_RS00355
uniprot id: A0A0R1YKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1423721:LA20533 RS01960
gene id: 1423721:LA20533_RS01960
uniprot id: A0A0R1YIS6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1423721:LA20533 RS06035
gene id: 1423721:LA20533_RS06035
uniprot id: A0A0R1YIA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

1423721:LA20533 RS00470
gene id: 1423721:LA20533_RS00470
uniprot id: A0A1L6XA79
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1423721:LA20533 RS00485
gene id: 1423721:LA20533_RS00485
uniprot id: A0A0R1YKC9
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06605
gene id: 1423721:LA20533_RS06605
uniprot id: A0A0R1YJ61
names: Similarity
messages: Belongs to the IMPACT family.

1423721:LA20533 RS06265
gene id: 1423721:LA20533_RS06265
uniprot id: A0A1L6XD32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

1423721:LA20533 RS07795
gene id: 1423721:LA20533_RS07795
uniprot id: A0A0R1YJS8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1423721:LA20533 RS03020
gene id: 1423721:LA20533_RS03020
uniprot id: A0A1L6XBF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 73 family.

1423721:LA20533 RS06120
gene id: 1423721:LA20533_RS06120
uniprot id: A0A0R1YI18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1423721:LA20533 RS06590
gene id: 1423721:LA20533_RS06590
uniprot id: A0A0R1YKZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1423721:LA20533 RS07975
gene id: 1423721:LA20533_RS07975
uniprot id: A0A0R1YKL8
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

1423721:LA20533 RS03800
gene id: 1423721:LA20533_RS03800
uniprot id: A0A1L6XBT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07435
gene id: 1423721:LA20533_RS07435
uniprot id: A0A0R1YS92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1423721:LA20533 RS01060
gene id: 1423721:LA20533_RS01060
uniprot id: A0A0R1YGN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

1423721:LA20533 RS05510
gene id: 1423721:LA20533_RS05510
uniprot id: A0A0R1YHU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1423721:LA20533 RS02700
gene id: 1423721:LA20533_RS02700
uniprot id: A0A1L6XBA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1423721:LA20533 RS06915
gene id: 1423721:LA20533_RS06915
uniprot id: A0A0R1YTW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS00300
gene id: 1423721:LA20533_RS00300
uniprot id: A0A0R1YV00
names: Similarity
messages: Belongs to the RecJ family.

1423721:LA20533 RS06075
gene id: 1423721:LA20533_RS06075
uniprot id: A0A0R1YPS1
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1423721:LA20533 RS03835
gene id: 1423721:LA20533_RS03835
uniprot id: A0A0R1YLY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1423721:LA20533 RS06525
gene id: 1423721:LA20533_RS06525
uniprot id: A0A1L6XED4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

1423721:LA20533 RS07380
gene id: 1423721:LA20533_RS07380
uniprot id: A0A0R1YRU3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03540
gene id: 1423721:LA20533_RS03540
uniprot id: A0A1L6XBN8
names: Similarity
messages: Belongs to the plasmid mobilization pre family.

1423721:LA20533 RS00630
gene id: 1423721:LA20533_RS00630
uniprot id: A0A0R1YT23
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS06330
gene id: 1423721:LA20533_RS06330
uniprot id: A0A1L6XD41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1423721:LA20533 RS03250
gene id: 1423721:LA20533_RS03250
uniprot id: A0A0R1YMA0
names: Subcellular Location Annotation
messages: Cytoplasm

1423721:LA20533 RS05050
gene id: 1423721:LA20533_RS05050
uniprot id: A0A0R1YL01
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1423721:LA20533 RS07615
gene id: 1423721:LA20533_RS07615
uniprot id: A0A0R1YJP4
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

1423721:LA20533 RS04365
gene id: 1423721:LA20533_RS04365
uniprot id: A0A0R1YM87
names: Similarity
messages: Belongs to the peptidase M20A family.

1423721:LA20533 RS02740
gene id: 1423721:LA20533_RS02740
uniprot id: A0A0R1YIW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS07505
gene id: 1423721:LA20533_RS07505
uniprot id: A0A0R1YU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS08255
gene id: 1423721:LA20533_RS08255
uniprot id: A0A0R1YK46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1423721:LA20533 RS05085
gene id: 1423721:LA20533_RS05085
uniprot id: A0A0R1YGY7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

1423721:LA20533 RS04015
gene id: 1423721:LA20533_RS04015
uniprot id: A0A0R1YMC3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

1423721:LA20533 RS04080
gene id: 1423721:LA20533_RS04080
uniprot id: A0A0R1YM17
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1423721:LA20533 RS05280
gene id: 1423721:LA20533_RS05280
uniprot id: A0A0R1YHY6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1423721:LA20533 RS07085
gene id: 1423721:LA20533_RS07085
uniprot id: A0A0R1YU02
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

1423721:LA20533 RS01925
gene id: 1423721:LA20533_RS01925
uniprot id: A0A0R1YQM0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1423721:LA20533 RS02220
gene id: 1423721:LA20533_RS02220
uniprot id: A0A1L6XB07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1423721:LA20533 RS06170
gene id: 1423721:LA20533_RS06170
uniprot id: A0A0R1YID6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

1423721:LA20533 RS04095
gene id: 1423721:LA20533_RS04095
uniprot id: A0A0R1YUK6
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

1423721:LA20533 RS07780
gene id: 1423721:LA20533_RS07780
uniprot id: A0A0R1YS33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1423721:LA20533 RS05460
gene id: 1423721:LA20533_RS05460
uniprot id: A0A1L6XCR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1423721:LA20533 RS03950
gene id: 1423721:LA20533_RS03950
uniprot id: A0A0R1YIM4
names: Similarity
messages: Belongs to the asp23 family.

1423721:LA20533 RS01950
gene id: 1423721:LA20533_RS01950
uniprot id: A0A1L6XE77
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS02390
gene id: 1423721:LA20533_RS02390
uniprot id: A0A0R1YIU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1423721:LA20533 RS00880
gene id: 1423721:LA20533_RS00880
uniprot id: A0A0R1YT78
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1423721:LA20533 RS07495
gene id: 1423721:LA20533_RS07495
uniprot id: A0A0R1YKG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

1423721:LA20533 RS02600
gene id: 1423721:LA20533_RS02600
uniprot id: A0A0R1YJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1423721:LA20533 RS02345
gene id: 1423721:LA20533_RS02345
uniprot id: A0A0R1YJ72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1423721:LA20533 RS07325
gene id: 1423721:LA20533_RS07325
uniprot id: A0A0R1YKD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1423721:LA20533 RS00975
gene id: 1423721:LA20533_RS00975
uniprot id: A0A1L6XAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1423721:LA20533 RS03205
gene id: 1423721:LA20533_RS03205
uniprot id: A0A0R1YL70
names: Caution
names: Subcellular Location Annotation
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS07005
gene id: 1423721:LA20533_RS07005
uniprot id: A0A1L6XDF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1423721:LA20533 RS06310
gene id: 1423721:LA20533_RS06310
uniprot id: A0A0R1YJ12
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

1423721:LA20533 RS07865
gene id: 1423721:LA20533_RS07865
uniprot id: A0A0R1YUJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1423721:LA20533 RS04265
gene id: 1423721:LA20533_RS04265
uniprot id: A0A0R1YX59
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02880
gene id: 1423721:LA20533_RS02880
uniprot id: A0A0R1YSW9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1423721:LA20533 RS08170
gene id: 1423721:LA20533_RS08170
uniprot id: A0A0R1YKG5
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1423721:LA20533 RS01700
gene id: 1423721:LA20533_RS01700
uniprot id: A0A0R1YQ21
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1423721:LA20533 RS01715
gene id: 1423721:LA20533_RS01715
uniprot id: A0A1L6XAR3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1423721:LA20533 RS00915
gene id: 1423721:LA20533_RS00915
uniprot id: A0A0R1YLE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

1423721:LA20533 RS06695
gene id: 1423721:LA20533_RS06695
uniprot id: A0A1L6XED5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1423721:LA20533 RS02490
gene id: 1423721:LA20533_RS02490
uniprot id: A0A1L6XB67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1423721:LA20533 RS06085
gene id: 1423721:LA20533_RS06085
uniprot id: A0A0R1YPX2
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

1423721:LA20533 RS07215
gene id: 1423721:LA20533_RS07215
uniprot id: A0A1L6XDK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS05990
gene id: 1423721:LA20533_RS05990
uniprot id: A0A0R1YMK6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS03755
gene id: 1423721:LA20533_RS03755
uniprot id: A0A0R1YLZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1423721:LA20533 RS04200
gene id: 1423721:LA20533_RS04200
uniprot id: A0A1L6XC08
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06595
gene id: 1423721:LA20533_RS06595
uniprot id: A0A0R1YRQ9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

1423721:LA20533 RS04255
gene id: 1423721:LA20533_RS04255
uniprot id: A0A0R1YN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

1423721:LA20533 RS02620
gene id: 1423721:LA20533_RS02620
uniprot id: A0A0R1YIE4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS07155
gene id: 1423721:LA20533_RS07155
uniprot id: A0A0R1YKA1
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1423721:LA20533 RS02135
gene id: 1423721:LA20533_RS02135
uniprot id: A0A0R1YIY3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1423721:LA20533 RS01070
gene id: 1423721:LA20533_RS01070
uniprot id: A0A0R1YGN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1423721:LA20533 RS03775
gene id: 1423721:LA20533_RS03775
uniprot id: A0A0R1YT67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1423721:LA20533 RS06470
gene id: 1423721:LA20533_RS06470
uniprot id: A0A0R1YJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS01605
gene id: 1423721:LA20533_RS01605
uniprot id: A0A0R1YHW7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1423721:LA20533 RS06585
gene id: 1423721:LA20533_RS06585
uniprot id: A0A0R1YNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

1423721:LA20533 RS05770
gene id: 1423721:LA20533_RS05770
uniprot id: A0A0R1YNG1
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS00195
gene id: 1423721:LA20533_RS00195
uniprot id: A0A0R1YK73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS01725
gene id: 1423721:LA20533_RS01725
uniprot id: A0A0R1YHW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1423721:LA20533 RS01765
gene id: 1423721:LA20533_RS01765
uniprot id: A0A0R1YHZ8
names: Similarity
messages: Belongs to the asparaginase 1 family.

1423721:LA20533 RS07610
gene id: 1423721:LA20533_RS07610
uniprot id: A0A1L6XEE6
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

1423721:LA20533 RS04105
gene id: 1423721:LA20533_RS04105
uniprot id: A0A0R1YMR5
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1423721:LA20533 RS08285
gene id: 1423721:LA20533_RS08285
uniprot id: A0A0R1YK61
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1423721:LA20533 RS02650
gene id: 1423721:LA20533_RS02650
uniprot id: A0A0R1YK79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS02630
gene id: 1423721:LA20533_RS02630
uniprot id: A0A0R1YIF1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1423721:LA20533 RS06750
gene id: 1423721:LA20533_RS06750
uniprot id: A0A0R1YL31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1423721:LA20533 RS02465
gene id: 1423721:LA20533_RS02465
uniprot id: A0A0R1YIB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1423721:LA20533 RS00690
gene id: 1423721:LA20533_RS00690
uniprot id: A0A0R1YL56
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1423721:LA20533 RS07630
gene id: 1423721:LA20533_RS07630
uniprot id: A0A1L6XDR6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1423721:LA20533 RS03095
gene id: 1423721:LA20533_RS03095
uniprot id: A0A0R1YM71
names: Similarity
messages: Belongs to the aldolase LacD family.

1423721:LA20533 RS08320
gene id: 1423721:LA20533_RS08320
uniprot id: A0A0R1YSR4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1423721:LA20533 RS04305
gene id: 1423721:LA20533_RS04305
uniprot id: A0A1L6XEA5
names: Similarity
messages: Belongs to the TPP enzyme family.

1423721:LA20533 RS07240
gene id: 1423721:LA20533_RS07240
uniprot id: A0A0R1YK66
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03080
gene id: 1423721:LA20533_RS03080
uniprot id: A0A0R1YI56
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1423721:LA20533 RS06370
gene id: 1423721:LA20533_RS06370
uniprot id: A0A0R1YK06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1423721:LA20533 RS02190
gene id: 1423721:LA20533_RS02190
uniprot id: A0A0R1YSI9
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1423721:LA20533 RS05835
gene id: 1423721:LA20533_RS05835
uniprot id: A0A0R1YMI6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1423721:LA20533 RS02730
gene id: 1423721:LA20533_RS02730
uniprot id: A0A0R1YK95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

1423721:LA20533 RS02615
gene id: 1423721:LA20533_RS02615
uniprot id: A0A0R1YJ51
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS03840
gene id: 1423721:LA20533_RS03840
uniprot id: A0A0R1YKR5
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

1423721:LA20533 RS03140
gene id: 1423721:LA20533_RS03140
uniprot id: A0A1L6XEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1423721:LA20533 RS02610
gene id: 1423721:LA20533_RS02610
uniprot id: A0A0R1YSS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1423721:LA20533 RS06425
gene id: 1423721:LA20533_RS06425
uniprot id: A0A0R1YNQ3
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1423721:LA20533 RS03855
gene id: 1423721:LA20533_RS03855
uniprot id: A0A0R1YT50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1423721:LA20533 RS00330
gene id: 1423721:LA20533_RS00330
uniprot id: A0A0R1YSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1423721:LA20533 RS01875
gene id: 1423721:LA20533_RS01875
uniprot id: A0A0R1YIR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1423721:LA20533 RS02400
gene id: 1423721:LA20533_RS02400
uniprot id: A0A1L6XB38
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1423721:LA20533 RS02635
gene id: 1423721:LA20533_RS02635
uniprot id: A0A0R1YJ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS01635
gene id: 1423721:LA20533_RS01635
uniprot id: A0A0R1YHV3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02020
gene id: 1423721:LA20533_RS02020
uniprot id: A0A0R1YJ02
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1423721:LA20533 RS00745
gene id: 1423721:LA20533_RS00745
uniprot id: A0A0R1YLA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1423721:LA20533 RS02360
gene id: 1423721:LA20533_RS02360
uniprot id: A0A0R1YSM0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1423721:LA20533 RS06560
gene id: 1423721:LA20533_RS06560
uniprot id: A0A0R1YKA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

1423721:LA20533 RS02365
gene id: 1423721:LA20533_RS02365
uniprot id: A0A0R1YIZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1423721:LA20533 RS00780
gene id: 1423721:LA20533_RS00780
uniprot id: A0A0R1YQ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1423721:LA20533 RS01860
gene id: 1423721:LA20533_RS01860
uniprot id: A0A0R1YIX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1423721:LA20533 RS00490
gene id: 1423721:LA20533_RS00490
uniprot id: A0A0R1YSY7
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02640
gene id: 1423721:LA20533_RS02640
uniprot id: A0A0R1YJ04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07880
gene id: 1423721:LA20533_RS07880
uniprot id: A0A0R1YL05
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1423721:LA20533 RS03475
gene id: 1423721:LA20533_RS03475
uniprot id: A0A1L6XE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.
messages: Membrane

1423721:LA20533 RS05215
gene id: 1423721:LA20533_RS05215
uniprot id: A0A0R1YI06
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1423721:LA20533 RS06900
gene id: 1423721:LA20533_RS06900
uniprot id: A0A0R1YJF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1423721:LA20533 RS02715
gene id: 1423721:LA20533_RS02715
uniprot id: A0A1L6XBA5
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1423721:LA20533 RS02150
gene id: 1423721:LA20533_RS02150
uniprot id: A0A0R1YMR8
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

1423721:LA20533 RS01115
gene id: 1423721:LA20533_RS01115
uniprot id: A0A0R1YHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PrsA family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.

1423721:LA20533 RS05755
gene id: 1423721:LA20533_RS05755
uniprot id: A0A0R1YMH3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1423721:LA20533 RS01880
gene id: 1423721:LA20533_RS01880
uniprot id: A0A0R1YI04
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1423721:LA20533 RS02655
gene id: 1423721:LA20533_RS02655
uniprot id: A0A0R1YQZ3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00955
gene id: 1423721:LA20533_RS00955
uniprot id: A0A1L6XAH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1423721:LA20533 RS07840
gene id: 1423721:LA20533_RS07840
uniprot id: A0A0R1YKA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

1423721:LA20533 RS07960
gene id: 1423721:LA20533_RS07960
uniprot id: A0A0R1YL25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1423721:LA20533 RS07360
gene id: 1423721:LA20533_RS07360
uniprot id: A0A0R1YJJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1423721:LA20533 RS06825
gene id: 1423721:LA20533_RS06825
uniprot id: A0A1L6XDC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1423721:LA20533 RS08130
gene id: 1423721:LA20533_RS08130
uniprot id: A0A0R1YL55
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS06535
gene id: 1423721:LA20533_RS06535
uniprot id: A0A0R1YK26
names: Similarity
messages: Belongs to the cycloisomerase 2 family.

1423721:LA20533 RS03345
gene id: 1423721:LA20533_RS03345
uniprot id: A0A1L6XBM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1423721:LA20533 RS06800
gene id: 1423721:LA20533_RS06800
uniprot id: A0A0R1YTU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1423721:LA20533 RS04090
gene id: 1423721:LA20533_RS04090
uniprot id: A0A0R1YN58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

1423721:LA20533 RS01190
gene id: 1423721:LA20533_RS01190
uniprot id: A0A0R1YGR6
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS06700
gene id: 1423721:LA20533_RS06700
uniprot id: A0A1L6XDA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1423721:LA20533 RS01855
gene id: 1423721:LA20533_RS01855
uniprot id: A0A0R1YQE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1423721:LA20533 RS00695
gene id: 1423721:LA20533_RS00695
uniprot id: A0A0R1YV96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1423721:LA20533 RS02940
gene id: 1423721:LA20533_RS02940
uniprot id: A0A0R1YJA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS00740
gene id: 1423721:LA20533_RS00740
uniprot id: A0A0R1YV93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1423721:LA20533 RS04705
gene id: 1423721:LA20533_RS04705
uniprot id: A0A0R1YTQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1423721:LA20533 RS08115
gene id: 1423721:LA20533_RS08115
uniprot id: A0A0R1YUP8
names: Similarity
messages: Belongs to the UPF0398 family.

1423721:LA20533 RS05680
gene id: 1423721:LA20533_RS05680
uniprot id: A0A0R1YLX0
names: Similarity
messages: Belongs to the plasmid replication initiation factor family.

1423721:LA20533 RS06175
gene id: 1423721:LA20533_RS06175
uniprot id: A0A0R1YPV9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1423721:LA20533 RS06795
gene id: 1423721:LA20533_RS06795
uniprot id: A0A1L6XDB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1423721:LA20533 RS02470
gene id: 1423721:LA20533_RS02470
uniprot id: A0A1L6XB64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1423721:LA20533 RS02295
gene id: 1423721:LA20533_RS02295
uniprot id: A0A1L6XB24
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS02070
gene id: 1423721:LA20533_RS02070
uniprot id: A0A0R1YSG6
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS03995
gene id: 1423721:LA20533_RS03995
uniprot id: A0A0R1YNB6
names: Similarity
messages: Belongs to the Gram-positive plasmids replication protein type 2 family.

1423721:LA20533 RS07555
gene id: 1423721:LA20533_RS07555
uniprot id: A0A0R1YUB4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1423721:LA20533 RS07430
gene id: 1423721:LA20533_RS07430
uniprot id: A0A0R1YLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1423721:LA20533 RS03215
gene id: 1423721:LA20533_RS03215
uniprot id: A0A0R1YTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS05450
gene id: 1423721:LA20533_RS05450
uniprot id: A0A0R1YQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS00395
gene id: 1423721:LA20533_RS00395
uniprot id: A0A0R1YSX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1423721:LA20533 RS00095
gene id: 1423721:LA20533_RS00095
uniprot id: A0A0R1YUU0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1423721:LA20533 RS04120
gene id: 1423721:LA20533_RS04120
uniprot id: A0A0R1YM39
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1423721:LA20533 RS01610
gene id: 1423721:LA20533_RS01610
uniprot id: A0A0R1YQ95
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1423721:LA20533 RS03935
gene id: 1423721:LA20533_RS03935
uniprot id: A0A1L6XBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1423721:LA20533 RS05135
gene id: 1423721:LA20533_RS05135
uniprot id: A0A0R1YKZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1423721:LA20533 RS00075
gene id: 1423721:LA20533_RS00075
uniprot id: A0A0R1YK46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1423721:LA20533 RS03700
gene id: 1423721:LA20533_RS03700
uniprot id: A0A1L6XBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS06620
gene id: 1423721:LA20533_RS06620
uniprot id: A0A1L6XD92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1423721:LA20533 RS08290
gene id: 1423721:LA20533_RS08290
uniprot id: A0A0R1YL92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1423721:LA20533 RS02310
gene id: 1423721:LA20533_RS02310
uniprot id: A0A0R1YSN3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS05825
gene id: 1423721:LA20533_RS05825
uniprot id: A0A0R1YLT6
names: Similarity
messages: Belongs to the UPF0246 family.

1423721:LA20533 RS06200
gene id: 1423721:LA20533_RS06200
uniprot id: A0A0R1YM22
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1423721:LA20533 RS00705
gene id: 1423721:LA20533_RS00705
uniprot id: A0A0R1YM81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1423721:LA20533 RS01035
gene id: 1423721:LA20533_RS01035
uniprot id: A0A0R1YP48
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS04860
gene id: 1423721:LA20533_RS04860
uniprot id: A0A0R1YNQ2
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1423721:LA20533 RS07915
gene id: 1423721:LA20533_RS07915
uniprot id: A0A0R1YSK4
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1423721:LA20533 RS08230
gene id: 1423721:LA20533_RS08230
uniprot id: A0A0R1YUU3
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

1423721:LA20533 RS08050
gene id: 1423721:LA20533_RS08050
uniprot id: A0A1L6XDY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1423721:LA20533 RS06650
gene id: 1423721:LA20533_RS06650
uniprot id: A0A0R1YK11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1423721:LA20533 RS05395
gene id: 1423721:LA20533_RS05395
uniprot id: A0A0R1YG61
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1423721:LA20533 RS04230
gene id: 1423721:LA20533_RS04230
uniprot id: A0A0R1YUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS00505
gene id: 1423721:LA20533_RS00505
uniprot id: A0A0R1YV37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1423721:LA20533 RS04235
gene id: 1423721:LA20533_RS04235
uniprot id: A0A0R1YMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS05025
gene id: 1423721:LA20533_RS05025
uniprot id: A0A0R1YNT3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS06270
gene id: 1423721:LA20533_RS06270
uniprot id: A0A0R1YJG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

1423721:LA20533 RS04960
gene id: 1423721:LA20533_RS04960
uniprot id: A0A1L6XCF1
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05415
gene id: 1423721:LA20533_RS05415
uniprot id: A0A1L6XCL8
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1423721:LA20533 RS06180
gene id: 1423721:LA20533_RS06180
uniprot id: A0A0R1YHJ0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1423721:LA20533 RS07350
gene id: 1423721:LA20533_RS07350
uniprot id: A0A0R1YS69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1423721:LA20533 RS00555
gene id: 1423721:LA20533_RS00555
uniprot id: A0A0R1YKT7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1423721:LA20533 RS08180
gene id: 1423721:LA20533_RS08180
uniprot id: A0A1L6XEF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS01185
gene id: 1423721:LA20533_RS01185
uniprot id: A0A0R1YH49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1423721:LA20533 RS04930
gene id: 1423721:LA20533_RS04930
uniprot id: A0A0R1YQS0
names: Similarity
messages: Belongs to the ParB family.

1423721:LA20533 RS00165
gene id: 1423721:LA20533_RS00165
uniprot id: A0A0R1YST8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1423721:LA20533 RS06690
gene id: 1423721:LA20533_RS06690
uniprot id: A0A0R1YRQ4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

1423721:LA20533 RS01890
gene id: 1423721:LA20533_RS01890
uniprot id: A0A0R1YI02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1423721:LA20533 RS00200
gene id: 1423721:LA20533_RS00200
uniprot id: A0A0R1YLB2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1423721:LA20533 RS03945
gene id: 1423721:LA20533_RS03945
uniprot id: A0A1L6XBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1423721:LA20533 RS08025
gene id: 1423721:LA20533_RS08025
uniprot id: A0A0R1YUM8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

1423721:LA20533 RS02265
gene id: 1423721:LA20533_RS02265
uniprot id: A0A0R1YQM7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1423721:LA20533 RS07735
gene id: 1423721:LA20533_RS07735
uniprot id: A0A0R1YKL2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1423721:LA20533 RS00370
gene id: 1423721:LA20533_RS00370
uniprot id: A0A0R1YL28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1423721:LA20533 RS07305
gene id: 1423721:LA20533_RS07305
uniprot id: A0A0R1YKC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS04340
gene id: 1423721:LA20533_RS04340
uniprot id: A0A0R1YUQ5
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS04785
gene id: 1423721:LA20533_RS04785
uniprot id: A0A0R1YNX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1423721:LA20533 RS01210
gene id: 1423721:LA20533_RS01210
uniprot id: A0A0R1YR24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1423721:LA20533 RS00035
gene id: 1423721:LA20533_RS00035
uniprot id: A0A0R1YKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS00735
gene id: 1423721:LA20533_RS00735
uniprot id: A0A0R1YSR3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1423721:LA20533 RS03860
gene id: 1423721:LA20533_RS03860
uniprot id: A0A0R1YLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS07800
gene id: 1423721:LA20533_RS07800
uniprot id: A0A0R1YKY8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1423721:LA20533 RS00685
gene id: 1423721:LA20533_RS00685
uniprot id: A0A0R1YLA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1423721:LA20533 RS04670
gene id: 1423721:LA20533_RS04670
uniprot id: A0A0R1YM41
names: Similarity
messages: Belongs to the ThiD family.

1423721:LA20533 RS04525
gene id: 1423721:LA20533_RS04525
uniprot id: A0A1L6XC69
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

1423721:LA20533 RS02375
gene id: 1423721:LA20533_RS02375
uniprot id: A0A0R1YJE7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1423721:LA20533 RS04580
gene id: 1423721:LA20533_RS04580
uniprot id: A0A0R1YR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS01660
gene id: 1423721:LA20533_RS01660
uniprot id: A0A0R1YS67
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1423721:LA20533 RS01065
gene id: 1423721:LA20533_RS01065
uniprot id: A0A0R1YHS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1423721:LA20533 RS02540
gene id: 1423721:LA20533_RS02540
uniprot id: A0A0R1YIC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1423721:LA20533 RS04160
gene id: 1423721:LA20533_RS04160
uniprot id: A0A0R1YM34
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS03355
gene id: 1423721:LA20533_RS03355
uniprot id: A0A0R1YTG3
names: Subcellular Location Annotation
messages: Membrane

1423721:LA20533 RS05760
gene id: 1423721:LA20533_RS05760
uniprot id: A0A0R1YWR1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1423721:LA20533 RS03795
gene id: 1423721:LA20533_RS03795
uniprot id: A0A0R1YLA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS04995
gene id: 1423721:LA20533_RS04995
uniprot id: A0A0R1YHF1
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1423721:LA20533 RS03910
gene id: 1423721:LA20533_RS03910
uniprot id: A0A1L6XEB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1423721:LA20533 RS00805
gene id: 1423721:LA20533_RS00805
uniprot id: A0A0R1YKJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S15 family.
messages: Homodimer.
messages: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

1423721:LA20533 RS01710
gene id: 1423721:LA20533_RS01710
uniprot id: A0A0R1YIM5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1423721:LA20533 RS06510
gene id: 1423721:LA20533_RS06510
uniprot id: A0A0R1YKX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS02405
gene id: 1423721:LA20533_RS02405
uniprot id: A0A0R1YMW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1423721:LA20533 RS01585
gene id: 1423721:LA20533_RS01585
uniprot id: A0A0R1YMF6
names: Function
messages: Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.

1423721:LA20533 RS07635
gene id: 1423721:LA20533_RS07635
uniprot id: A0A0R1YUC8
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1423721:LA20533 RS05080
gene id: 1423721:LA20533_RS05080
uniprot id: A0A0R1YGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1423721:LA20533 RS04290
gene id: 1423721:LA20533_RS04290
uniprot id: A0A0R1YMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1423721:LA20533 RS04150
gene id: 1423721:LA20533_RS04150
uniprot id: A0A0R1YUU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1423721:LA20533 RS02545
gene id: 1423721:LA20533_RS02545
uniprot id: A0A1L6XB91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

1423721:LA20533 RS06550
gene id: 1423721:LA20533_RS06550
uniprot id: A0A0R1YJW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1423721:LA20533 RS00825
gene id: 1423721:LA20533_RS00825
uniprot id: A0A0R1YVB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1423721:LA20533 RS04100
gene id: 1423721:LA20533_RS04100
uniprot id: A0A0R1YX18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1423721:LA20533 RS04035
gene id: 1423721:LA20533_RS04035
uniprot id: A0A1L6XBX8
names: Function
messages: Involved in the transposition of the insertion sequence.

1423721:LA20533 RS03770
gene id: 1423721:LA20533_RS03770
uniprot id: A0A0R1YVP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1423721:LA20533 RS06705
gene id: 1423721:LA20533_RS06705
uniprot id: A0A0R1YTS9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1423721:LA20533 RS02100
gene id: 1423721:LA20533_RS02100
uniprot id: A0A0R1YJ24
names: Subcellular Location Annotation
messages: Membrane