1379910:TH63 RS03510
gene id: 1379910:TH63_RS03510
uniprot id: A0A0H4VMC0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1379910:TH63 RS15380
gene id: 1379910:TH63_RS15380
uniprot id: A0A0H4VPA2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS07340
gene id: 1379910:TH63_RS07340
uniprot id: A0A0H4W500
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1379910:TH63 RS02465
gene id: 1379910:TH63_RS02465
uniprot id: A0A0H4VLY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1379910:TH63 RS08815
gene id: 1379910:TH63_RS08815
uniprot id: A0A0H4VPS9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1379910:TH63 RS03175
gene id: 1379910:TH63_RS03175
uniprot id: A0A0H4VM62
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS01720
gene id: 1379910:TH63_RS01720
uniprot id: A0A0H4VL63
names: Similarity
messages: Belongs to the pirin family.

1379910:TH63 RS17930
gene id: 1379910:TH63_RS17930
uniprot id: A0A0H4VMJ7
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS07220
gene id: 1379910:TH63_RS07220
uniprot id: A0A0H4VI97
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1379910:TH63 RS10590
gene id: 1379910:TH63_RS10590
uniprot id: A0A0H4VPY2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS07725
gene id: 1379910:TH63_RS07725
uniprot id: A0A0H4VJP1
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

1379910:TH63 RS19425
gene id: 1379910:TH63_RS19425
uniprot id: A0A0H4VPU0
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1379910:TH63 RS08365
gene id: 1379910:TH63_RS08365
uniprot id: A0A0H4VJX7
names: Similarity
messages: Belongs to the MQO family.

1379910:TH63 RS12290
gene id: 1379910:TH63_RS12290
uniprot id: A0A0H4VR53
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1379910:TH63 RS18895
gene id: 1379910:TH63_RS18895
uniprot id: A0A0H4VPL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1379910:TH63 RS05865
gene id: 1379910:TH63_RS05865
uniprot id: A0A0H4VN22
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS17520
gene id: 1379910:TH63_RS17520
uniprot id: A0A0H4VNZ4
names: Similarity
messages: Belongs to the RecJ family.

1379910:TH63 RS14860
gene id: 1379910:TH63_RS14860
uniprot id: A0A0H4W860
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS11270
gene id: 1379910:TH63_RS11270
uniprot id: A0A0H4VL83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1379910:TH63 RS15665
gene id: 1379910:TH63_RS15665
uniprot id: A0A0H4VSI3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1379910:TH63 RS05010
gene id: 1379910:TH63_RS05010
uniprot id: A0A0H4VN25
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS18095
gene id: 1379910:TH63_RS18095
uniprot id: A0A0H4W9J7
names: Similarity
messages: Belongs to the UPF0047 family.

1379910:TH63 RS08585
gene id: 1379910:TH63_RS08585
uniprot id: A0A0H4W5K6
names: Similarity
messages: Belongs to the nitroreductase family.

1379910:TH63 RS10895
gene id: 1379910:TH63_RS10895
uniprot id: A0A0H4VL09
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15915
gene id: 1379910:TH63_RS15915
uniprot id: A0A0H4VN83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1379910:TH63 RS10945
gene id: 1379910:TH63_RS10945
uniprot id: A0A0H4VJR2
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS09085
gene id: 1379910:TH63_RS09085
uniprot id: A0A0H4VK89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1379910:TH63 RS02150
gene id: 1379910:TH63_RS02150
uniprot id: A0A0H4W2N0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1379910:TH63 RS15500
gene id: 1379910:TH63_RS15500
uniprot id: A0A0H4VSF2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS09575
gene id: 1379910:TH63_RS09575
uniprot id: A0A0H4W5X4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1379910:TH63 RS14410
gene id: 1379910:TH63_RS14410
uniprot id: A0A0H4W7Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

1379910:TH63 RS15690
gene id: 1379910:TH63_RS15690
uniprot id: A0A0H4VN46
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS00145
gene id: 1379910:TH63_RS00145
uniprot id: A0A0H4VKW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1379910:TH63 RS01080
gene id: 1379910:TH63_RS01080
uniprot id: A0A0H4VFZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1379910:TH63 RS10035
gene id: 1379910:TH63_RS10035
uniprot id: A0A0H4W640
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS06310
gene id: 1379910:TH63_RS06310
uniprot id: A0A0H4W4I9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS01225
gene id: 1379910:TH63_RS01225
uniprot id: A0A0H4VLE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1379910:TH63 RS05930
gene id: 1379910:TH63_RS05930
uniprot id: A0A0H4VN31
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1379910:TH63 RS09565
gene id: 1379910:TH63_RS09565
uniprot id: A0A0H4VQ24
names: Similarity
messages: Belongs to the aspartokinase family.

1379910:TH63 RS14095
gene id: 1379910:TH63_RS14095
uniprot id: A0A0H4W7T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

1379910:TH63 RS13860
gene id: 1379910:TH63_RS13860
uniprot id: A0A0H4VKY8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05775
gene id: 1379910:TH63_RS05775
uniprot id: A0A0H4VN10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1379910:TH63 RS19135
gene id: 1379910:TH63_RS19135
uniprot id: A0A0H4W9X4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1379910:TH63 RS01210
gene id: 1379910:TH63_RS01210
uniprot id: A0A0H4W2B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1379910:TH63 RS07305
gene id: 1379910:TH63_RS07305
uniprot id: A0A0H4W4Z3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1379910:TH63 RS19285
gene id: 1379910:TH63_RS19285
uniprot id: A0A0H4VN12
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

1379910:TH63 RS01790
gene id: 1379910:TH63_RS01790
uniprot id: A0A0H4VLL5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1379910:TH63 RS14545
gene id: 1379910:TH63_RS14545
uniprot id: A0A0H4VRN1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1379910:TH63 RS01025
gene id: 1379910:TH63_RS01025
uniprot id: A0A0H4VFY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1379910:TH63 RS09260
gene id: 1379910:TH63_RS09260
uniprot id: A0A0H4VKB0
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

1379910:TH63 RS10995
gene id: 1379910:TH63_RS10995
uniprot id: A0A0H4VL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS18910
gene id: 1379910:TH63_RS18910
uniprot id: A0A0H4VV80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1379910:TH63 RS12440
gene id: 1379910:TH63_RS12440
uniprot id: A0A0H4VQN2
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1379910:TH63 RS05350
gene id: 1379910:TH63_RS05350
uniprot id: A0A0H4VIH2
names: Function
messages: May be involved in the biogenesis of curli organelles.

1379910:TH63 RS05935
gene id: 1379910:TH63_RS05935
uniprot id: A0A0H4VIP8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS16155
gene id: 1379910:TH63_RS16155
uniprot id: A0A0H4VNC4
names: Similarity
messages: Belongs to the DSD1 family.

1379910:TH63 RS11505
gene id: 1379910:TH63_RS11505
uniprot id: A0A0H4VQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1379910:TH63 RS18210
gene id: 1379910:TH63_RS18210
uniprot id: A0A0H4W9K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS13210
gene id: 1379910:TH63_RS13210
uniprot id: A0A0H4VR05
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS04850
gene id: 1379910:TH63_RS04850
uniprot id: A0A0H4W3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS07835
gene id: 1379910:TH63_RS07835
uniprot id: A0A0H4VPF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1379910:TH63 RS04165
gene id: 1379910:TH63_RS04165
uniprot id: A0A0H4W3J0
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

1379910:TH63 RS11250
gene id: 1379910:TH63_RS11250
uniprot id: A0A0H4VQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1379910:TH63 RS04910
gene id: 1379910:TH63_RS04910
uniprot id: A0A0H4VN08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1379910:TH63 RS12050
gene id: 1379910:TH63_RS12050
uniprot id: A0A0H4VK70
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

1379910:TH63 RS19235
gene id: 1379910:TH63_RS19235
uniprot id: A0A0H4VN02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS11705
gene id: 1379910:TH63_RS11705
uniprot id: A0A0H4W6U3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1379910:TH63 RS08175
gene id: 1379910:TH63_RS08175
uniprot id: A0A0H4VPJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1379910:TH63 RS18795
gene id: 1379910:TH63_RS18795
uniprot id: A0A0H4W9S9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1379910:TH63 RS08630
gene id: 1379910:TH63_RS08630
uniprot id: A0A0H4VP63
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1379910:TH63 RS18000
gene id: 1379910:TH63_RS18000
uniprot id: A0A0H4VT61
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1379910:TH63 RS06610
gene id: 1379910:TH63_RS06610
uniprot id: A0A0H4VNS0
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

1379910:TH63 RS08875
gene id: 1379910:TH63_RS08875
uniprot id: A0A0H4W5P4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1379910:TH63 RS09705
gene id: 1379910:TH63_RS09705
uniprot id: A0A0H4VJ61
names: Similarity
messages: Belongs to the peptidase S9C family.

1379910:TH63 RS13935
gene id: 1379910:TH63_RS13935
uniprot id: A0A0H4VMC3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS04505
gene id: 1379910:TH63_RS04505
uniprot id: A0A0H4W3S9
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

1379910:TH63 RS00195
gene id: 1379910:TH63_RS00195
uniprot id: A0A0H4VFL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS17430
gene id: 1379910:TH63_RS17430
uniprot id: A0A0H4VMD1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1379910:TH63 RS17665
gene id: 1379910:TH63_RS17665
uniprot id: A0A0H4VVD0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1379910:TH63 RS03395
gene id: 1379910:TH63_RS03395
uniprot id: A0A0H4VMA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS17630
gene id: 1379910:TH63_RS17630
uniprot id: A0A0H4VMF4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS05315
gene id: 1379910:TH63_RS05315
uniprot id: A0A0H4VIG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1379910:TH63 RS00245
gene id: 1379910:TH63_RS00245
uniprot id: A0A0H4VKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS07940
gene id: 1379910:TH63_RS07940
uniprot id: A0A0H4VJS3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

1379910:TH63 RS00730
gene id: 1379910:TH63_RS00730
uniprot id: A0A0H4VKS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

1379910:TH63 RS16410
gene id: 1379910:TH63_RS16410
uniprot id: A0A0H4VV18
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1379910:TH63 RS10635
gene id: 1379910:TH63_RS10635
uniprot id: A0A0H4VKY3
names: Function
names: Similarity
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.

1379910:TH63 RS00260
gene id: 1379910:TH63_RS00260
uniprot id: A0A0H4W1X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS14705
gene id: 1379910:TH63_RS14705
uniprot id: A0A0H4VMQ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1379910:TH63 RS01700
gene id: 1379910:TH63_RS01700
uniprot id: A0A0H4VLK0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1379910:TH63 RS16395
gene id: 1379910:TH63_RS16395
uniprot id: A0A0H4VNG7
names: Similarity
messages: Belongs to the Skp family.

1379910:TH63 RS05320
gene id: 1379910:TH63_RS05320
uniprot id: A0A0H4VN66
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

1379910:TH63 RS13175
gene id: 1379910:TH63_RS13175
uniprot id: A0A0H4VQY4
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1379910:TH63 RS12265
gene id: 1379910:TH63_RS12265
uniprot id: A0A0H4VR50
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS13825
gene id: 1379910:TH63_RS13825
uniprot id: A0A0H4VKY4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS16810
gene id: 1379910:TH63_RS16810
uniprot id: A0A0H4VT00
names: Similarity
messages: Belongs to the peptidase S13 family.

1379910:TH63 RS07915
gene id: 1379910:TH63_RS07915
uniprot id: A0A0H4VJR6
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

1379910:TH63 RS08865
gene id: 1379910:TH63_RS08865
uniprot id: A0A0H4VPT4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS16900
gene id: 1379910:TH63_RS16900
uniprot id: A0A0H4VM63
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1379910:TH63 RS14385
gene id: 1379910:TH63_RS14385
uniprot id: A0A0H4VRI6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1379910:TH63 RS03410
gene id: 1379910:TH63_RS03410
uniprot id: A0A0H4VGY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1379910:TH63 RS14400
gene id: 1379910:TH63_RS14400
uniprot id: A0A0H4VRX7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS18410
gene id: 1379910:TH63_RS18410
uniprot id: A0A0H4W9M9
names: Similarity
messages: Belongs to the peptidase U62 family.

1379910:TH63 RS06955
gene id: 1379910:TH63_RS06955
uniprot id: A0A0H4VJ80
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

1379910:TH63 RS06455
gene id: 1379910:TH63_RS06455
uniprot id: A0A0H4VI10
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS17305
gene id: 1379910:TH63_RS17305
uniprot id: A0A0H4VVC0
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS12505
gene id: 1379910:TH63_RS12505
uniprot id: A0A0H4VKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1379910:TH63 RS07440
gene id: 1379910:TH63_RS07440
uniprot id: A0A0H4VNR1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1379910:TH63 RS00815
gene id: 1379910:TH63_RS00815
uniprot id: A0A0H4VKT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1379910:TH63 RS15235
gene id: 1379910:TH63_RS15235
uniprot id: A0A0H4VRV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1379910:TH63 RS00030
gene id: 1379910:TH63_RS00030
uniprot id: A0A0H4VKU8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1379910:TH63 RS09850
gene id: 1379910:TH63_RS09850
uniprot id: A0A0H4VKK9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1379910:TH63 RS07700
gene id: 1379910:TH63_RS07700
uniprot id: A0A0H4VJL9
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

1379910:TH63 RS07545
gene id: 1379910:TH63_RS07545
uniprot id: A0A0H4VNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1379910:TH63 RS08855
gene id: 1379910:TH63_RS08855
uniprot id: A0A0H4VK53
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1379910:TH63 RS10070
gene id: 1379910:TH63_RS10070
uniprot id: A0A0H4VKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

1379910:TH63 RS04130
gene id: 1379910:TH63_RS04130
uniprot id: A0A0H4VH47
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1379910:TH63 RS00975
gene id: 1379910:TH63_RS00975
uniprot id: A0A0H4VL69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

1379910:TH63 RS06565
gene id: 1379910:TH63_RS06565
uniprot id: A0A0H4VJ19
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS11225
gene id: 1379910:TH63_RS11225
uniprot id: A0A0H4VJX2
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

1379910:TH63 RS18145
gene id: 1379910:TH63_RS18145
uniprot id: A0A0H4VPA4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05740
gene id: 1379910:TH63_RS05740
uniprot id: A0A0H4VN05
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1379910:TH63 RS10795
gene id: 1379910:TH63_RS10795
uniprot id: A0A0H4VQI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1379910:TH63 RS16730
gene id: 1379910:TH63_RS16730
uniprot id: A0A0H4VSG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS07585
gene id: 1379910:TH63_RS07585
uniprot id: A0A0H4VID5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1379910:TH63 RS09040
gene id: 1379910:TH63_RS09040
uniprot id: A0A0H4W5R7
names: PTM
messages: Binds 1 heme c group covalently per subunit.

1379910:TH63 RS16525
gene id: 1379910:TH63_RS16525
uniprot id: A0A0H4W8U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1379910:TH63 RS15740
gene id: 1379910:TH63_RS15740
uniprot id: A0A0H4W8G8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS19560
gene id: 1379910:TH63_RS19560
uniprot id: A0A0H4VPW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

1379910:TH63 RS08835
gene id: 1379910:TH63_RS08835
uniprot id: A0A0H4VP88
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS18085
gene id: 1379910:TH63_RS18085
uniprot id: A0A0H4VML2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1379910:TH63 RS08090
gene id: 1379910:TH63_RS08090
uniprot id: A0A0H4VJU0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS00200
gene id: 1379910:TH63_RS00200
uniprot id: A0A0H4W1W5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS04500
gene id: 1379910:TH63_RS04500
uniprot id: A0A0H4VHB4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

1379910:TH63 RS12280
gene id: 1379910:TH63_RS12280
uniprot id: A0A0H4VQJ5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08800
gene id: 1379910:TH63_RS08800
uniprot id: A0A0H4VP84
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1379910:TH63 RS01365
gene id: 1379910:TH63_RS01365
uniprot id: A0A0H4VLF9
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

1379910:TH63 RS18265
gene id: 1379910:TH63_RS18265
uniprot id: A0A0H4VMN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1379910:TH63 RS00210
gene id: 1379910:TH63_RS00210
uniprot id: A0A0H4VGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS02720
gene id: 1379910:TH63_RS02720
uniprot id: A0A0H4VLJ9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1379910:TH63 RS18605
gene id: 1379910:TH63_RS18605
uniprot id: A0A0H4W9Q6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1379910:TH63 RS18745
gene id: 1379910:TH63_RS18745
uniprot id: A0A0H4VPI8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1379910:TH63 RS10585
gene id: 1379910:TH63_RS10585
uniprot id: A0A0H4W6C9
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1379910:TH63 RS06315
gene id: 1379910:TH63_RS06315
uniprot id: A0A0H4VN96
names: Similarity
messages: Belongs to the threonine synthase family.

1379910:TH63 RS00265
gene id: 1379910:TH63_RS00265
uniprot id: A0A0H4VKL1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS13640
gene id: 1379910:TH63_RS13640
uniprot id: A0A0H4VUX1
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

1379910:TH63 RS05105
gene id: 1379910:TH63_RS05105
uniprot id: A0A0H4VIE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS04125
gene id: 1379910:TH63_RS04125
uniprot id: A0A0H4VMK1
names: Similarity
messages: Belongs to the ArsC family.

1379910:TH63 RS14090
gene id: 1379910:TH63_RS14090
uniprot id: A0A0H4VL14
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

1379910:TH63 RS09810
gene id: 1379910:TH63_RS09810
uniprot id: A0A0H4VPL4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS01135
gene id: 1379910:TH63_RS01135
uniprot id: A0A0H4W278
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1379910:TH63 RS18120
gene id: 1379910:TH63_RS18120
uniprot id: A0A0H4VV65
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1379910:TH63 RS06295
gene id: 1379910:TH63_RS06295
uniprot id: A0A0H4VUB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1379910:TH63 RS13235
gene id: 1379910:TH63_RS13235
uniprot id: A0A0H4VKN9
names: Similarity
messages: Belongs to the thioredoxin family.

1379910:TH63 RS05825
gene id: 1379910:TH63_RS05825
uniprot id: A0A0H4VN17
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

1379910:TH63 RS01085
gene id: 1379910:TH63_RS01085
uniprot id: A0A0H4W267
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1379910:TH63 RS16035
gene id: 1379910:TH63_RS16035
uniprot id: A0A0H4VLV1
names: Similarity
messages: Belongs to the GbsR family.

1379910:TH63 RS10205
gene id: 1379910:TH63_RS10205
uniprot id: A0A0H4VPS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS02080
gene id: 1379910:TH63_RS02080
uniprot id: A0A0H4VLA6
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15065
gene id: 1379910:TH63_RS15065
uniprot id: A0A0H4VLH7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

1379910:TH63 RS19370
gene id: 1379910:TH63_RS19370
uniprot id: A0A0H4WBF1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1379910:TH63 RS08960
gene id: 1379910:TH63_RS08960
uniprot id: A0A0H4VK68
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

1379910:TH63 RS11720
gene id: 1379910:TH63_RS11720
uniprot id: A0A0H4VLD5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS06695
gene id: 1379910:TH63_RS06695
uniprot id: A0A0H4W4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1379910:TH63 RS12375
gene id: 1379910:TH63_RS12375
uniprot id: A0A0H4VQM6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

1379910:TH63 RS04670
gene id: 1379910:TH63_RS04670
uniprot id: A0A0H4VIB9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS08850
gene id: 1379910:TH63_RS08850
uniprot id: A0A0H4VUT4
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

1379910:TH63 RS01335
gene id: 1379910:TH63_RS01335
uniprot id: A0A0H4VTY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1379910:TH63 RS05055
gene id: 1379910:TH63_RS05055
uniprot id: A0A0H4W403
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1379910:TH63 RS12570
gene id: 1379910:TH63_RS12570
uniprot id: A0A0H4VQP8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1379910:TH63 RS07410
gene id: 1379910:TH63_RS07410
uniprot id: A0A0H4VNQ8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS07455
gene id: 1379910:TH63_RS07455
uniprot id: A0A0H4VIC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1379910:TH63 RS00845
gene id: 1379910:TH63_RS00845
uniprot id: A0A0H4VFV6
names: Similarity
messages: Belongs to the YciI family.

1379910:TH63 RS00675
gene id: 1379910:TH63_RS00675
uniprot id: A0A0H4W212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS07210
gene id: 1379910:TH63_RS07210
uniprot id: A0A0H4VJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS09115
gene id: 1379910:TH63_RS09115
uniprot id: A0A0H4VK94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1379910:TH63 RS02525
gene id: 1379910:TH63_RS02525
uniprot id: A0A0H4W2T0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1379910:TH63 RS13710
gene id: 1379910:TH63_RS13710
uniprot id: A0A0H4VR75
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS16495
gene id: 1379910:TH63_RS16495
uniprot id: A0A0H4VM13
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1379910:TH63 RS11135
gene id: 1379910:TH63_RS11135
uniprot id: A0A0H4VL68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS10500
gene id: 1379910:TH63_RS10500
uniprot id: A0A0H4W6B3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS09050
gene id: 1379910:TH63_RS09050
uniprot id: A0A0H4VPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

1379910:TH63 RS14285
gene id: 1379910:TH63_RS14285
uniprot id: A0A0H4W7X2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1379910:TH63 RS18435
gene id: 1379910:TH63_RS18435
uniprot id: A0A0H4W9N2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1379910:TH63 RS12715
gene id: 1379910:TH63_RS12715
uniprot id: A0A0H4W782
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS01125
gene id: 1379910:TH63_RS01125
uniprot id: A0A0H4VL93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1379910:TH63 RS19215
gene id: 1379910:TH63_RS19215
uniprot id: A0A0H4W9Y3
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1379910:TH63 RS01100
gene id: 1379910:TH63_RS01100
uniprot id: A0A0H4VL89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1379910:TH63 RS01885
gene id: 1379910:TH63_RS01885
uniprot id: A0A0H4VGE2
names: Similarity
messages: Belongs to the peptidase M24B family.

1379910:TH63 RS17060
gene id: 1379910:TH63_RS17060
uniprot id: A0A0H4W933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

1379910:TH63 RS08890
gene id: 1379910:TH63_RS08890
uniprot id: A0A0H4VP91
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS01240
gene id: 1379910:TH63_RS01240
uniprot id: A0A0H4VL15
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1379910:TH63 RS06735
gene id: 1379910:TH63_RS06735
uniprot id: A0A0H4W4Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1379910:TH63 RS16685
gene id: 1379910:TH63_RS16685
uniprot id: A0A0H4VSY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS09520
gene id: 1379910:TH63_RS09520
uniprot id: A0A0H4W5W4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1379910:TH63 RS04740
gene id: 1379910:TH63_RS04740
uniprot id: A0A0H4VU75
names: Similarity
messages: Belongs to the peptidase S58 family.

1379910:TH63 RS03545
gene id: 1379910:TH63_RS03545
uniprot id: A0A0H4W385
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1379910:TH63 RS05430
gene id: 1379910:TH63_RS05430
uniprot id: A0A0H4VIH9
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

1379910:TH63 RS18705
gene id: 1379910:TH63_RS18705
uniprot id: A0A0H4W9R7
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1379910:TH63 RS13925
gene id: 1379910:TH63_RS13925
uniprot id: A0A0H4VRA9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1379910:TH63 RS11930
gene id: 1379910:TH63_RS11930
uniprot id: A0A0H4VQG3
names: Similarity
messages: Belongs to the sulfatase family.

1379910:TH63 RS10975
gene id: 1379910:TH63_RS10975
uniprot id: A0A0H4VQL3
names: Similarity
messages: Belongs to the thioredoxin family.

1379910:TH63 RS10925
gene id: 1379910:TH63_RS10925
uniprot id: A0A0H4VQ28
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1379910:TH63 RS18790
gene id: 1379910:TH63_RS18790
uniprot id: A0A0H4VMU4
names: Similarity
messages: Belongs to the UPF0102 family.

1379910:TH63 RS00705
gene id: 1379910:TH63_RS00705
uniprot id: A0A0H4VFT7
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS15055
gene id: 1379910:TH63_RS15055
uniprot id: A0A0H4VMU5
names: Similarity
messages: Belongs to the UPF0234 family.

1379910:TH63 RS10625
gene id: 1379910:TH63_RS10625
uniprot id: A0A0H4VPY8
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1379910:TH63 RS10565
gene id: 1379910:TH63_RS10565
uniprot id: A0A0H4VPX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1379910:TH63 RS17050
gene id: 1379910:TH63_RS17050
uniprot id: A0A0H4VM83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1379910:TH63 RS15845
gene id: 1379910:TH63_RS15845
uniprot id: A0A0H4VN73
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1379910:TH63 RS14300
gene id: 1379910:TH63_RS14300
uniprot id: A0A0H4VRW6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1379910:TH63 RS10155
gene id: 1379910:TH63_RS10155
uniprot id: A0A0H4VKE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1379910:TH63 RS16360
gene id: 1379910:TH63_RS16360
uniprot id: A0A0H4VSU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1379910:TH63 RS10800
gene id: 1379910:TH63_RS10800
uniprot id: A0A0H4VJM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

1379910:TH63 RS16725
gene id: 1379910:TH63_RS16725
uniprot id: A0A0H4W8X8
names: Similarity
messages: Belongs to the CarB family.

1379910:TH63 RS02890
gene id: 1379910:TH63_RS02890
uniprot id: A0A0H4W2Y8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1379910:TH63 RS20635
gene id: 1379910:TH63_RS20635
uniprot id: A0A0H4VNH0
names: Similarity
messages: Belongs to the YciI family.

1379910:TH63 RS07530
gene id: 1379910:TH63_RS07530
uniprot id: A0A0H4VP74
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS14655
gene id: 1379910:TH63_RS14655
uniprot id: A0A0H4W839
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS06760
gene id: 1379910:TH63_RS06760
uniprot id: A0A0H4VNT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1379910:TH63 RS12255
gene id: 1379910:TH63_RS12255
uniprot id: A0A0H4VQJ1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1379910:TH63 RS10510
gene id: 1379910:TH63_RS10510
uniprot id: A0A0H4VKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS00690
gene id: 1379910:TH63_RS00690
uniprot id: A0A0H4VL33
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS04610
gene id: 1379910:TH63_RS04610
uniprot id: A0A0H4VIB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1379910:TH63 RS09060
gene id: 1379910:TH63_RS09060
uniprot id: A0A0H4VPW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

1379910:TH63 RS05490
gene id: 1379910:TH63_RS05490
uniprot id: A0A0H4VN95
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1379910:TH63 RS10120
gene id: 1379910:TH63_RS10120
uniprot id: A0A0H4VQA1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01805
gene id: 1379910:TH63_RS01805
uniprot id: A0A0H4VL75
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS12395
gene id: 1379910:TH63_RS12395
uniprot id: A0A0H4VR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1379910:TH63 RS06180
gene id: 1379910:TH63_RS06180
uniprot id: A0A0H4VNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1379910:TH63 RS07820
gene id: 1379910:TH63_RS07820
uniprot id: A0A0H4W5A5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1379910:TH63 RS01195
gene id: 1379910:TH63_RS01195
uniprot id: A0A0H4VH36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1379910:TH63 RS16115
gene id: 1379910:TH63_RS16115
uniprot id: A0A0H4VNB8
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

1379910:TH63 RS06520
gene id: 1379910:TH63_RS06520
uniprot id: A0A0H4VNQ6
names: Similarity
messages: Belongs to the TrpF family.

1379910:TH63 RS14050
gene id: 1379910:TH63_RS14050
uniprot id: A0A0H4VL10
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

1379910:TH63 RS15920
gene id: 1379910:TH63_RS15920
uniprot id: A0A0H4VSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1379910:TH63 RS16345
gene id: 1379910:TH63_RS16345
uniprot id: A0A0H4W8S4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1379910:TH63 RS07225
gene id: 1379910:TH63_RS07225
uniprot id: A0A0H4W4X5
names: Similarity
messages: Belongs to the DtxR/MntR family.

1379910:TH63 RS01895
gene id: 1379910:TH63_RS01895
uniprot id: A0A0H4W2J7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1379910:TH63 RS12145
gene id: 1379910:TH63_RS12145
uniprot id: A0A0H4VR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1379910:TH63 RS12010
gene id: 1379910:TH63_RS12010
uniprot id: A0A0H4VR18
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS11370
gene id: 1379910:TH63_RS11370
uniprot id: A0A0H4VL91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1379910:TH63 RS00765
gene id: 1379910:TH63_RS00765
uniprot id: A0A0H4VKS7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

1379910:TH63 RS07270
gene id: 1379910:TH63_RS07270
uniprot id: A0A0H4VP32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS11340
gene id: 1379910:TH63_RS11340
uniprot id: A0A0H4VJY1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08390
gene id: 1379910:TH63_RS08390
uniprot id: A0A0H4VP29
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1379910:TH63 RS19185
gene id: 1379910:TH63_RS19185
uniprot id: A0A0H4VTK7
names: Similarity
messages: Belongs to the Vsr family.

1379910:TH63 RS17155
gene id: 1379910:TH63_RS17155
uniprot id: A0A0H4VNU3
names: Similarity
messages: Belongs to the pirin family.

1379910:TH63 RS18880
gene id: 1379910:TH63_RS18880
uniprot id: A0A0H4VMV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1379910:TH63 RS03185
gene id: 1379910:TH63_RS03185
uniprot id: A0A0H4W330
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS16455
gene id: 1379910:TH63_RS16455
uniprot id: A0A0H4VSV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS03485
gene id: 1379910:TH63_RS03485
uniprot id: A0A0H4VGZ1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS12080
gene id: 1379910:TH63_RS12080
uniprot id: A0A0H4VLH6
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1379910:TH63 RS08750
gene id: 1379910:TH63_RS08750
uniprot id: A0A0H4VPS1
names: Similarity
messages: Belongs to the asparaginase 1 family.

1379910:TH63 RS04775
gene id: 1379910:TH63_RS04775
uniprot id: A0A0H4VMY7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1379910:TH63 RS05585
gene id: 1379910:TH63_RS05585
uniprot id: A0A0H4VHP7
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

1379910:TH63 RS01155
gene id: 1379910:TH63_RS01155
uniprot id: A0A0H4VG17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1379910:TH63 RS06350
gene id: 1379910:TH63_RS06350
uniprot id: A0A0H4W4J6
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1379910:TH63 RS19030
gene id: 1379910:TH63_RS19030
uniprot id: A0A0H4VTX4
names: Subunit
messages: Monomer.

1379910:TH63 RS13705
gene id: 1379910:TH63_RS13705
uniprot id: A0A0H4W7L6
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS12460
gene id: 1379910:TH63_RS12460
uniprot id: A0A0H4VLN0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08545
gene id: 1379910:TH63_RS08545
uniprot id: A0A0H4VIR4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1379910:TH63 RS01980
gene id: 1379910:TH63_RS01980
uniprot id: A0A0H4VLR9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS13030
gene id: 1379910:TH63_RS13030
uniprot id: A0A0H4VRE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1379910:TH63 RS16760
gene id: 1379910:TH63_RS16760
uniprot id: A0A0H4W8Y2
names: Similarity
messages: Belongs to the DEAD box helicase family.

1379910:TH63 RS07800
gene id: 1379910:TH63_RS07800
uniprot id: A0A0H4VNW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1379910:TH63 RS01090
gene id: 1379910:TH63_RS01090
uniprot id: A0A0H4VKX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1379910:TH63 RS03690
gene id: 1379910:TH63_RS03690
uniprot id: A0A0H4VHV2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00865
gene id: 1379910:TH63_RS00865
uniprot id: A0A0H4VL54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1379910:TH63 RS15310
gene id: 1379910:TH63_RS15310
uniprot id: A0A0H4VMY6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

1379910:TH63 RS05140
gene id: 1379910:TH63_RS05140
uniprot id: A0A0H4VN43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS03190
gene id: 1379910:TH63_RS03190
uniprot id: A0A0H4WAF0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1379910:TH63 RS04680
gene id: 1379910:TH63_RS04680
uniprot id: A0A0H4VHD7
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS04225
gene id: 1379910:TH63_RS04225
uniprot id: A0A0H4W3K1
names: Similarity
messages: Belongs to the glutamate synthase family.

1379910:TH63 RS04450
gene id: 1379910:TH63_RS04450
uniprot id: A0A0H4VI55
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08280
gene id: 1379910:TH63_RS08280
uniprot id: A0A0H4VP20
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1379910:TH63 RS08480
gene id: 1379910:TH63_RS08480
uniprot id: A0A0H4W5J1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-57 and Arg-60) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

1379910:TH63 RS11980
gene id: 1379910:TH63_RS11980
uniprot id: A0A0H4W6X6
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

1379910:TH63 RS00180
gene id: 1379910:TH63_RS00180
uniprot id: A0A0H4VGJ8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1379910:TH63 RS12155
gene id: 1379910:TH63_RS12155
uniprot id: A0A0H4W701
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1379910:TH63 RS06020
gene id: 1379910:TH63_RS06020
uniprot id: A0A0H4VIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1379910:TH63 RS03760
gene id: 1379910:TH63_RS03760
uniprot id: A0A0H4VM07
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

1379910:TH63 RS00780
gene id: 1379910:TH63_RS00780
uniprot id: A0A0H4VFU7
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

1379910:TH63 RS00505
gene id: 1379910:TH63_RS00505
uniprot id: A0A0H4VL07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

1379910:TH63 RS17695
gene id: 1379910:TH63_RS17695
uniprot id: A0A0H4VSY0
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1379910:TH63 RS06905
gene id: 1379910:TH63_RS06905
uniprot id: A0A0H4VJ71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1379910:TH63 RS07260
gene id: 1379910:TH63_RS07260
uniprot id: A0A0H4VQD4
names: Similarity
messages: Belongs to the peptidase S51 family.

1379910:TH63 RS01300
gene id: 1379910:TH63_RS01300
uniprot id: A0A0H4VH48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS13645
gene id: 1379910:TH63_RS13645
uniprot id: A0A0H4W7K8
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1379910:TH63 RS10245
gene id: 1379910:TH63_RS10245
uniprot id: A0A0H4VUW1
names: Similarity
messages: Belongs to the peptidase S9C family.

1379910:TH63 RS10445
gene id: 1379910:TH63_RS10445
uniprot id: A0A0H4W6A0
names: Similarity
messages: Belongs to the fabD family.

1379910:TH63 RS19350
gene id: 1379910:TH63_RS19350
uniprot id: A0A0H4VPT1
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1379910:TH63 RS12285
gene id: 1379910:TH63_RS12285
uniprot id: A0A0H4VLK6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1379910:TH63 RS18955
gene id: 1379910:TH63_RS18955
uniprot id: A0A0H4VVF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS02235
gene id: 1379910:TH63_RS02235
uniprot id: A0A0H4VGI1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS16130
gene id: 1379910:TH63_RS16130
uniprot id: A0A0H4VLW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1379910:TH63 RS10180
gene id: 1379910:TH63_RS10180
uniprot id: A0A0H4VPR8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS14405
gene id: 1379910:TH63_RS14405
uniprot id: A0A0H4VL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

1379910:TH63 RS14910
gene id: 1379910:TH63_RS14910
uniprot id: A0A0H4VS77
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

1379910:TH63 RS17080
gene id: 1379910:TH63_RS17080
uniprot id: A0A0H4VM87
names: Similarity
messages: Belongs to the NusB family.

1379910:TH63 RS12510
gene id: 1379910:TH63_RS12510
uniprot id: A0A0H4W750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1379910:TH63 RS09110
gene id: 1379910:TH63_RS09110
uniprot id: A0A0H4VPB1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS10465
gene id: 1379910:TH63_RS10465
uniprot id: A0A0H4VQE8
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1379910:TH63 RS16575
gene id: 1379910:TH63_RS16575
uniprot id: A0A0H4VSX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1379910:TH63 RS06615
gene id: 1379910:TH63_RS06615
uniprot id: A0A0H4VI32
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

1379910:TH63 RS07065
gene id: 1379910:TH63_RS07065
uniprot id: A0A0H4VP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1379910:TH63 RS16355
gene id: 1379910:TH63_RS16355
uniprot id: A0A0H4VNG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1379910:TH63 RS02885
gene id: 1379910:TH63_RS02885
uniprot id: A0A0H4VGS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1379910:TH63 RS14455
gene id: 1379910:TH63_RS14455
uniprot id: A0A0H4VS29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1379910:TH63 RS11420
gene id: 1379910:TH63_RS11420
uniprot id: A0A0H4VQB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1379910:TH63 RS04090
gene id: 1379910:TH63_RS04090
uniprot id: A0A0H4VH45
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS14150
gene id: 1379910:TH63_RS14150
uniprot id: A0A0H4VRE0
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1379910:TH63 RS13065
gene id: 1379910:TH63_RS13065
uniprot id: A0A0H4VKL7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1379910:TH63 RS05945
gene id: 1379910:TH63_RS05945
uniprot id: A0A0H4VHT8
names: Similarity
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.

1379910:TH63 RS08810
gene id: 1379910:TH63_RS08810
uniprot id: A0A0H4VK48
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1379910:TH63 RS13220
gene id: 1379910:TH63_RS13220
uniprot id: A0A0H4VM10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS11220
gene id: 1379910:TH63_RS11220
uniprot id: A0A0H4VQR4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1379910:TH63 RS17690
gene id: 1379910:TH63_RS17690
uniprot id: A0A0H4VPE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1379910:TH63 RS16085
gene id: 1379910:TH63_RS16085
uniprot id: A0A0H4VNB3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1379910:TH63 RS09615
gene id: 1379910:TH63_RS09615
uniprot id: A0A0H4VKG8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

1379910:TH63 RS03300
gene id: 1379910:TH63_RS03300
uniprot id: A0A0H4VHR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1379910:TH63 RS12015
gene id: 1379910:TH63_RS12015
uniprot id: A0A0H4VK66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS16030
gene id: 1379910:TH63_RS16030
uniprot id: A0A0H4VSP2
names: Similarity
messages: Belongs to the AHA1 family.

1379910:TH63 RS12500
gene id: 1379910:TH63_RS12500
uniprot id: A0A0H4VR79
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1379910:TH63 RS07470
gene id: 1379910:TH63_RS07470
uniprot id: A0A0H4VJJ2
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

1379910:TH63 RS17590
gene id: 1379910:TH63_RS17590
uniprot id: A0A0H4VTA3
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1379910:TH63 RS15890
gene id: 1379910:TH63_RS15890
uniprot id: A0A0H4VPB0
names: Similarity
messages: Belongs to the peptidase S41A family.

1379910:TH63 RS02440
gene id: 1379910:TH63_RS02440
uniprot id: A0A0H4VLY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS12725
gene id: 1379910:TH63_RS12725
uniprot id: A0A0H4VQS2
names: Similarity
messages: Belongs to the ComB family.

1379910:TH63 RS00050
gene id: 1379910:TH63_RS00050
uniprot id: A0A0H4W1U7
names: Similarity
messages: Belongs to the YicC/YloC family.

1379910:TH63 RS10200
gene id: 1379910:TH63_RS10200
uniprot id: A0A0H4W668
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1379910:TH63 RS14380
gene id: 1379910:TH63_RS14380
uniprot id: A0A0H4W7Z0
names: Similarity
messages: Belongs to the Dps family.

1379910:TH63 RS16815
gene id: 1379910:TH63_RS16815
uniprot id: A0A0H4VM52
names: Similarity
messages: Belongs to the peptidase S66 family.

1379910:TH63 RS06085
gene id: 1379910:TH63_RS06085
uniprot id: A0A0H4VNI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

1379910:TH63 RS13390
gene id: 1379910:TH63_RS13390
uniprot id: A0A0H4VKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS01115
gene id: 1379910:TH63_RS01115
uniprot id: A0A0H4VKY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1379910:TH63 RS17435
gene id: 1379910:TH63_RS17435
uniprot id: A0A0H4W9A0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1379910:TH63 RS16520
gene id: 1379910:TH63_RS16520
uniprot id: A0A0H4VM17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1379910:TH63 RS03505
gene id: 1379910:TH63_RS03505
uniprot id: A0A0H4VHT2
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1379910:TH63 RS08130
gene id: 1379910:TH63_RS08130
uniprot id: A0A0H4VIL1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1379910:TH63 RS02460
gene id: 1379910:TH63_RS02460
uniprot id: A0A0H4VHG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

1379910:TH63 RS06240
gene id: 1379910:TH63_RS06240
uniprot id: A0A0H4VIV1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1379910:TH63 RS02145
gene id: 1379910:TH63_RS02145
uniprot id: A0A0H4VGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS08110
gene id: 1379910:TH63_RS08110
uniprot id: A0A0H4VP04
names: Similarity
messages: Belongs to the MoaD family.

1379910:TH63 RS16910
gene id: 1379910:TH63_RS16910
uniprot id: A0A0H4W903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1379910:TH63 RS15870
gene id: 1379910:TH63_RS15870
uniprot id: A0A0H4W8I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1379910:TH63 RS01235
gene id: 1379910:TH63_RS01235
uniprot id: A0A0H4W2B6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1379910:TH63 RS09595
gene id: 1379910:TH63_RS09595
uniprot id: A0A0H4VJ45
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1379910:TH63 RS19245
gene id: 1379910:TH63_RS19245
uniprot id: A0A0H4VTL9
names: Similarity
messages: Belongs to the LOG family.

1379910:TH63 RS18920
gene id: 1379910:TH63_RS18920
uniprot id: A0A0H4VMW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

1379910:TH63 RS04530
gene id: 1379910:TH63_RS04530
uniprot id: A0A0H4VHB8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

1379910:TH63 RS03525
gene id: 1379910:TH63_RS03525
uniprot id: A0A0H4VLV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1379910:TH63 RS07920
gene id: 1379910:TH63_RS07920
uniprot id: A0A0H4VPG0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS00700
gene id: 1379910:TH63_RS00700
uniprot id: A0A0H4WA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS19475
gene id: 1379910:TH63_RS19475
uniprot id: A0A0H4VPU9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1379910:TH63 RS18285
gene id: 1379910:TH63_RS18285
uniprot id: A0A0H4VTL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1379910:TH63 RS12250
gene id: 1379910:TH63_RS12250
uniprot id: A0A0H4VV08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

1379910:TH63 RS06840
gene id: 1379910:TH63_RS06840
uniprot id: A0A0H4VNV5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01785
gene id: 1379910:TH63_RS01785
uniprot id: A0A0H4VH87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1379910:TH63 RS09320
gene id: 1379910:TH63_RS09320
uniprot id: A0A0H4VKB8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1379910:TH63 RS09285
gene id: 1379910:TH63_RS09285
uniprot id: A0A0H4VKB3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1379910:TH63 RS16135
gene id: 1379910:TH63_RS16135
uniprot id: A0A0H4W8P4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01780
gene id: 1379910:TH63_RS01780
uniprot id: A0A0H4VL70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1379910:TH63 RS04560
gene id: 1379910:TH63_RS04560
uniprot id: A0A0H4W3T8
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS05040
gene id: 1379910:TH63_RS05040
uniprot id: A0A0H4VHH9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1379910:TH63 RS01880
gene id: 1379910:TH63_RS01880
uniprot id: A0A0H4VLN1
names: Similarity
messages: Belongs to the peptidase S8 family.

1379910:TH63 RS16800
gene id: 1379910:TH63_RS16800
uniprot id: A0A0H4VSH4
names: Similarity
messages: Belongs to the peptidase C40 family.

1379910:TH63 RS15075
gene id: 1379910:TH63_RS15075
uniprot id: A0A0H4VRT8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS02780
gene id: 1379910:TH63_RS02780
uniprot id: A0A0H4VHK2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1379910:TH63 RS13025
gene id: 1379910:TH63_RS13025
uniprot id: A0A0H4VLX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

1379910:TH63 RS19305
gene id: 1379910:TH63_RS19305
uniprot id: A0A0H4VU18
names: Similarity
messages: Belongs to the arginase family.

1379910:TH63 RS06525
gene id: 1379910:TH63_RS06525
uniprot id: A0A0H4VI23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1379910:TH63 RS17460
gene id: 1379910:TH63_RS17460
uniprot id: A0A0H4W9A6
names: Similarity
messages: Belongs to the RutC family.

1379910:TH63 RS02880
gene id: 1379910:TH63_RS02880
uniprot id: A0A0H4VM35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS15250
gene id: 1379910:TH63_RS15250
uniprot id: A0A0H4VLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1379910:TH63 RS11915
gene id: 1379910:TH63_RS11915
uniprot id: A0A0H4VK56
names: Similarity
messages: Belongs to the sulfatase family.

1379910:TH63 RS12520
gene id: 1379910:TH63_RS12520
uniprot id: A0A0H4VLP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS15780
gene id: 1379910:TH63_RS15780
uniprot id: A0A0H4VS16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS10400
gene id: 1379910:TH63_RS10400
uniprot id: A0A0H4VQD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Mitochondrion

1379910:TH63 RS13815
gene id: 1379910:TH63_RS13815
uniprot id: A0A0H4VRP6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1379910:TH63 RS07810
gene id: 1379910:TH63_RS07810
uniprot id: A0A0H4VPD5
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1379910:TH63 RS11530
gene id: 1379910:TH63_RS11530
uniprot id: A0A0H4W6S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1379910:TH63 RS01445
gene id: 1379910:TH63_RS01445
uniprot id: A0A0H4VLH0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1379910:TH63 RS18300
gene id: 1379910:TH63_RS18300
uniprot id: A0A0H4VPG8
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

1379910:TH63 RS10515
gene id: 1379910:TH63_RS10515
uniprot id: A0A0H4VQF7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS15230
gene id: 1379910:TH63_RS15230
uniprot id: A0A0H4W8A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1379910:TH63 RS19430
gene id: 1379910:TH63_RS19430
uniprot id: A0A0H4VU34
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1379910:TH63 RS04520
gene id: 1379910:TH63_RS04520
uniprot id: A0A0H4VIA3
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1379910:TH63 RS18110
gene id: 1379910:TH63_RS18110
uniprot id: A0A0H4VPA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

1379910:TH63 RS13530
gene id: 1379910:TH63_RS13530
uniprot id: A0A0H4VKU1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1379910:TH63 RS07565
gene id: 1379910:TH63_RS07565
uniprot id: A0A0H4W536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS02700
gene id: 1379910:TH63_RS02700
uniprot id: A0A0H4VHI9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1379910:TH63 RS18815
gene id: 1379910:TH63_RS18815
uniprot id: A0A0H4VTU6
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1379910:TH63 RS11005
gene id: 1379910:TH63_RS11005
uniprot id: A0A0H4VJS4
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1379910:TH63 RS12650
gene id: 1379910:TH63_RS12650
uniprot id: A0A0H4VKF4
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

1379910:TH63 RS09625
gene id: 1379910:TH63_RS09625
uniprot id: A0A0H4VNV8
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

1379910:TH63 RS10655
gene id: 1379910:TH63_RS10655
uniprot id: A0A0H4VQM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

1379910:TH63 RS18945
gene id: 1379910:TH63_RS18945
uniprot id: A0A0H4VPL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS15335
gene id: 1379910:TH63_RS15335
uniprot id: A0A0H4VRW4
names: Similarity
messages: Belongs to the peptidase C56 family.

1379910:TH63 RS16850
gene id: 1379910:TH63_RS16850
uniprot id: A0A0H4W8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1379910:TH63 RS15975
gene id: 1379910:TH63_RS15975
uniprot id: A0A0H4VN92
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1379910:TH63 RS00110
gene id: 1379910:TH63_RS00110
uniprot id: A0A0H4VKI7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS01150
gene id: 1379910:TH63_RS01150
uniprot id: A0A0H4VL98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1379910:TH63 RS10665
gene id: 1379910:TH63_RS10665
uniprot id: A0A0H4VJL7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS14370
gene id: 1379910:TH63_RS14370
uniprot id: A0A0H4VRX3
names: Function
names: Similarity
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.

1379910:TH63 RS00230
gene id: 1379910:TH63_RS00230
uniprot id: A0A0H4W1W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1379910:TH63 RS06640
gene id: 1379910:TH63_RS06640
uniprot id: A0A0H4VNS4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS05715
gene id: 1379910:TH63_RS05715
uniprot id: A0A0H4VIM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1379910:TH63 RS07795
gene id: 1379910:TH63_RS07795
uniprot id: A0A0H4W5A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1379910:TH63 RS11245
gene id: 1379910:TH63_RS11245
uniprot id: A0A0H4VL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

1379910:TH63 RS15810
gene id: 1379910:TH63_RS15810
uniprot id: A0A0H4W8H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1379910:TH63 RS05600
gene id: 1379910:TH63_RS05600
uniprot id: A0A0H4VIK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

1379910:TH63 RS19610
gene id: 1379910:TH63_RS19610
uniprot id: A0A0H4VPX4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15605
gene id: 1379910:TH63_RS15605
uniprot id: A0A0H4W8E6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS06100
gene id: 1379910:TH63_RS06100
uniprot id: A0A0H4VHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1379910:TH63 RS14275
gene id: 1379910:TH63_RS14275
uniprot id: A0A0H4VRW0
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1379910:TH63 RS07785
gene id: 1379910:TH63_RS07785
uniprot id: A0A0H4VPD0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1379910:TH63 RS13990
gene id: 1379910:TH63_RS13990
uniprot id: A0A0H4VL02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS19035
gene id: 1379910:TH63_RS19035
uniprot id: A0A0H4VMX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1379910:TH63 RS13915
gene id: 1379910:TH63_RS13915
uniprot id: A0A0H4VKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1379910:TH63 RS18885
gene id: 1379910:TH63_RS18885
uniprot id: A0A0H4W9U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1379910:TH63 RS13940
gene id: 1379910:TH63_RS13940
uniprot id: A0A0H4VQV2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS19595
gene id: 1379910:TH63_RS19595
uniprot id: A0A0H4VN60
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1379910:TH63 RS02785
gene id: 1379910:TH63_RS02785
uniprot id: A0A0H4VM23
names: Similarity
messages: Belongs to the HisA/HisF family.

1379910:TH63 RS19420
gene id: 1379910:TH63_RS19420
uniprot id: A0A0H4VTP9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS01060
gene id: 1379910:TH63_RS01060
uniprot id: A0A0H4W261
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1379910:TH63 RS07165
gene id: 1379910:TH63_RS07165
uniprot id: A0A0H4W4W4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1379910:TH63 RS11320
gene id: 1379910:TH63_RS11320
uniprot id: A0A0H4W6P8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15840
gene id: 1379910:TH63_RS15840
uniprot id: A0A0H4VS24
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS05270
gene id: 1379910:TH63_RS05270
uniprot id: A0A0H4VHK5
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

1379910:TH63 RS00070
gene id: 1379910:TH63_RS00070
uniprot id: A0A0H4VKV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1379910:TH63 RS15940
gene id: 1379910:TH63_RS15940
uniprot id: A0A0H4VS51
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS15970
gene id: 1379910:TH63_RS15970
uniprot id: A0A0H4VS56
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1379910:TH63 RS05515
gene id: 1379910:TH63_RS05515
uniprot id: A0A0H4VNA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1379910:TH63 RS01130
gene id: 1379910:TH63_RS01130
uniprot id: A0A0H4VG06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1379910:TH63 RS19255
gene id: 1379910:TH63_RS19255
uniprot id: A0A0H4VU07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS05660
gene id: 1379910:TH63_RS05660
uniprot id: A0A0H4VNC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1379910:TH63 RS09185
gene id: 1379910:TH63_RS09185
uniprot id: A0A0H4VUK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1379910:TH63 RS15125
gene id: 1379910:TH63_RS15125
uniprot id: A0A0H4VMV4
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

1379910:TH63 RS12045
gene id: 1379910:TH63_RS12045
uniprot id: A0A0H4VR23
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS06360
gene id: 1379910:TH63_RS06360
uniprot id: A0A0H4VIX3
names: Similarity
messages: Belongs to the DEAD box helicase family.

1379910:TH63 RS01970
gene id: 1379910:TH63_RS01970
uniprot id: A0A0H4VL94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1379910:TH63 RS18185
gene id: 1379910:TH63_RS18185
uniprot id: A0A0H4VPA9
names: Similarity
messages: Belongs to the peptidase S9A family.

1379910:TH63 RS04415
gene id: 1379910:TH63_RS04415
uniprot id: A0A0H4VMC9
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.

1379910:TH63 RS18595
gene id: 1379910:TH63_RS18595
uniprot id: A0A0H4VTR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1379910:TH63 RS12030
gene id: 1379910:TH63_RS12030
uniprot id: A0A0H4VLH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS02555
gene id: 1379910:TH63_RS02555
uniprot id: A0A0H4VLH3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS00740
gene id: 1379910:TH63_RS00740
uniprot id: A0A0H4VL38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1379910:TH63 RS02280
gene id: 1379910:TH63_RS02280
uniprot id: A0A0H4VLC7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1379910:TH63 RS07465
gene id: 1379910:TH63_RS07465
uniprot id: A0A0H4VNR4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

1379910:TH63 RS01050
gene id: 1379910:TH63_RS01050
uniprot id: A0A0H4VL78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1379910:TH63 RS13060
gene id: 1379910:TH63_RS13060
uniprot id: A0A0H4VRF6
names: Similarity
messages: Belongs to the CinA family.

1379910:TH63 RS02930
gene id: 1379910:TH63_RS02930
uniprot id: A0A0H4W2Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1379910:TH63 RS16885
gene id: 1379910:TH63_RS16885
uniprot id: A0A0H4VVB1
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

1379910:TH63 RS13845
gene id: 1379910:TH63_RS13845
uniprot id: A0A0H4VR95
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS01530
gene id: 1379910:TH63_RS01530
uniprot id: A0A0H4VH61
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1379910:TH63 RS16445
gene id: 1379910:TH63_RS16445
uniprot id: A0A0H4VSD0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS14135
gene id: 1379910:TH63_RS14135
uniprot id: A0A0H4VRU0
names: Similarity
messages: Belongs to the MreC family.

1379910:TH63 RS01910
gene id: 1379910:TH63_RS01910
uniprot id: A0A0H4VHA0
names: Subcellular Location Annotation
messages: Nucleus

1379910:TH63 RS07365
gene id: 1379910:TH63_RS07365
uniprot id: A0A0H4VNP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

1379910:TH63 RS09055
gene id: 1379910:TH63_RS09055
uniprot id: A0A0H4VK86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1379910:TH63 RS05760
gene id: 1379910:TH63_RS05760
uniprot id: A0A0H4VHR9
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS13270
gene id: 1379910:TH63_RS13270
uniprot id: A0A0H4VRI0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS03470
gene id: 1379910:TH63_RS03470
uniprot id: A0A0H4VHS8
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1379910:TH63 RS01965
gene id: 1379910:TH63_RS01965
uniprot id: A0A0H4W2K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1379910:TH63 RS06530
gene id: 1379910:TH63_RS06530
uniprot id: A0A0H4W4M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1379910:TH63 RS10495
gene id: 1379910:TH63_RS10495
uniprot id: A0A0H4VJJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS12325
gene id: 1379910:TH63_RS12325
uniprot id: A0A0H4VKA6
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1379910:TH63 RS12950
gene id: 1379910:TH63_RS12950
uniprot id: A0A0H4VKJ8
names: Similarity
messages: Belongs to the P(II) protein family.

1379910:TH63 RS12615
gene id: 1379910:TH63_RS12615
uniprot id: A0A0H4VR97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1379910:TH63 RS10570
gene id: 1379910:TH63_RS10570
uniprot id: A0A0H4VKX3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS17910
gene id: 1379910:TH63_RS17910
uniprot id: A0A0H4W9H2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS02875
gene id: 1379910:TH63_RS02875
uniprot id: A0A0H4VHL3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1379910:TH63 RS11970
gene id: 1379910:TH63_RS11970
uniprot id: A0A0H4VK61
names: Similarity
messages: Belongs to the sulfatase family.

1379910:TH63 RS11035
gene id: 1379910:TH63_RS11035
uniprot id: A0A0H4VJT1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

1379910:TH63 RS05510
gene id: 1379910:TH63_RS05510
uniprot id: A0A0H4VIJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1379910:TH63 RS08935
gene id: 1379910:TH63_RS08935
uniprot id: A0A0H4VPU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS11260
gene id: 1379910:TH63_RS11260
uniprot id: A0A0H4W6P3
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1379910:TH63 RS10770
gene id: 1379910:TH63_RS10770
uniprot id: A0A0H4VQ03
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

1379910:TH63 RS05605
gene id: 1379910:TH63_RS05605
uniprot id: A0A0H4VNB5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

1379910:TH63 RS17700
gene id: 1379910:TH63_RS17700
uniprot id: A0A0H4VP11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS16590
gene id: 1379910:TH63_RS16590
uniprot id: A0A0H4W8W0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01955
gene id: 1379910:TH63_RS01955
uniprot id: A0A0H4VLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1379910:TH63 RS19250
gene id: 1379910:TH63_RS19250
uniprot id: A0A0H4VPR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1379910:TH63 RS03645
gene id: 1379910:TH63_RS03645
uniprot id: A0A0H4VU54
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01180
gene id: 1379910:TH63_RS01180
uniprot id: A0A0H4VG54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1379910:TH63 RS05860
gene id: 1379910:TH63_RS05860
uniprot id: A0A0H4W4C2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS12970
gene id: 1379910:TH63_RS12970
uniprot id: A0A0H4VRD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1379910:TH63 RS09450
gene id: 1379910:TH63_RS09450
uniprot id: A0A0H4VKE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1379910:TH63 RS01245
gene id: 1379910:TH63_RS01245
uniprot id: A0A0H4VH41
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1379910:TH63 RS18890
gene id: 1379910:TH63_RS18890
uniprot id: A0A0H4VTH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1379910:TH63 RS16230
gene id: 1379910:TH63_RS16230
uniprot id: A0A0H4VLX5
names: Similarity
messages: Belongs to the sigma-54 factor family.

1379910:TH63 RS01870
gene id: 1379910:TH63_RS01870
uniprot id: A0A0H4WAB5
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1379910:TH63 RS06320
gene id: 1379910:TH63_RS06320
uniprot id: A0A0H4VIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1379910:TH63 RS16370
gene id: 1379910:TH63_RS16370
uniprot id: A0A0H4VLZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1379910:TH63 RS08245
gene id: 1379910:TH63_RS08245
uniprot id: A0A0H4VIM7
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1379910:TH63 RS18235
gene id: 1379910:TH63_RS18235
uniprot id: A0A0H4VMM5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS10065
gene id: 1379910:TH63_RS10065
uniprot id: A0A0H4VPQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS04390
gene id: 1379910:TH63_RS04390
uniprot id: A0A0H4VI45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1379910:TH63 RS14835
gene id: 1379910:TH63_RS14835
uniprot id: A0A0H4VMS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

1379910:TH63 RS08950
gene id: 1379910:TH63_RS08950
uniprot id: A0A0H4W5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

1379910:TH63 RS13725
gene id: 1379910:TH63_RS13725
uniprot id: A0A0H4VKW9
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS14230
gene id: 1379910:TH63_RS14230
uniprot id: A0A0H4W7W0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1379910:TH63 RS05915
gene id: 1379910:TH63_RS05915
uniprot id: A0A0H4VHT4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1379910:TH63 RS19240
gene id: 1379910:TH63_RS19240
uniprot id: A0A0H4W9Y7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS03985
gene id: 1379910:TH63_RS03985
uniprot id: A0A0H4WAG4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

1379910:TH63 RS10295
gene id: 1379910:TH63_RS10295
uniprot id: A0A0H4VPT7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1379910:TH63 RS17090
gene id: 1379910:TH63_RS17090
uniprot id: A0A0H4VSM8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS16235
gene id: 1379910:TH63_RS16235
uniprot id: A0A0H4W8Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS02530
gene id: 1379910:TH63_RS02530
uniprot id: A0A0H4VLG7
names: Similarity
messages: Belongs to the pyruvate kinase family.

1379910:TH63 RS10040
gene id: 1379910:TH63_RS10040
uniprot id: A0A0H4VPP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

1379910:TH63 RS19060
gene id: 1379910:TH63_RS19060
uniprot id: A0A0H4WBE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1379910:TH63 RS07095
gene id: 1379910:TH63_RS07095
uniprot id: A0A0H4VP12
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS02020
gene id: 1379910:TH63_RS02020
uniprot id: A0A0H4VLS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1379910:TH63 RS00940
gene id: 1379910:TH63_RS00940
uniprot id: A0A0H4VKV1
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

1379910:TH63 RS07110
gene id: 1379910:TH63_RS07110
uniprot id: A0A0H4VNL4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1379910:TH63 RS19870
gene id: 1379910:TH63_RS19870
uniprot id: A0A0H4VNZ8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1379910:TH63 RS11330
gene id: 1379910:TH63_RS11330
uniprot id: A0A0H4VL87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS16870
gene id: 1379910:TH63_RS16870
uniprot id: A0A0H4VM59
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1379910:TH63 RS18530
gene id: 1379910:TH63_RS18530
uniprot id: A0A0H4VPG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1379910:TH63 RS11255
gene id: 1379910:TH63_RS11255
uniprot id: A0A0H4VJX4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS07290
gene id: 1379910:TH63_RS07290
uniprot id: A0A0H4VJE4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1379910:TH63 RS10410
gene id: 1379910:TH63_RS10410
uniprot id: A0A0H4VJI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

1379910:TH63 RS07335
gene id: 1379910:TH63_RS07335
uniprot id: A0A0H4VIB0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1379910:TH63 RS12090
gene id: 1379910:TH63_RS12090
uniprot id: A0A0H4VK75
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1379910:TH63 RS18005
gene id: 1379910:TH63_RS18005
uniprot id: A0A0H4VP93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1379910:TH63 RS01145
gene id: 1379910:TH63_RS01145
uniprot id: A0A0H4VGZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1379910:TH63 RS09585
gene id: 1379910:TH63_RS09585
uniprot id: A0A0H4VKG2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1379910:TH63 RS00605
gene id: 1379910:TH63_RS00605
uniprot id: A0A0H4VL22
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS12750
gene id: 1379910:TH63_RS12750
uniprot id: A0A0H4VQS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1379910:TH63 RS10370
gene id: 1379910:TH63_RS10370
uniprot id: A0A0H4W691
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS09545
gene id: 1379910:TH63_RS09545
uniprot id: A0A0H4W5W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS04475
gene id: 1379910:TH63_RS04475
uniprot id: A0A0H4VME0
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS16295
gene id: 1379910:TH63_RS16295
uniprot id: A0A0H4W8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1379910:TH63 RS03200
gene id: 1379910:TH63_RS03200
uniprot id: A0A0H4VHQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS02870
gene id: 1379910:TH63_RS02870
uniprot id: A0A0H4VLM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

1379910:TH63 RS16545
gene id: 1379910:TH63_RS16545
uniprot id: A0A0H4VSW6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1379910:TH63 RS17410
gene id: 1379910:TH63_RS17410
uniprot id: A0A0H4VNY3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1379910:TH63 RS07250
gene id: 1379910:TH63_RS07250
uniprot id: A0A0H4W4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS08145
gene id: 1379910:TH63_RS08145
uniprot id: A0A0H4VJU8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1379910:TH63 RS07690
gene id: 1379910:TH63_RS07690
uniprot id: A0A0H4W559
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS19355
gene id: 1379910:TH63_RS19355
uniprot id: A0A0H4VU27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

1379910:TH63 RS13920
gene id: 1379910:TH63_RS13920
uniprot id: A0A0H4W7Q5
names: Similarity
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

1379910:TH63 RS03045
gene id: 1379910:TH63_RS03045
uniprot id: A0A0H4VM48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1379910:TH63 RS09275
gene id: 1379910:TH63_RS09275
uniprot id: A0A0H4W5T4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1379910:TH63 RS11770
gene id: 1379910:TH63_RS11770
uniprot id: A0A0H4VLE4
names: Similarity
messages: Belongs to the SCO1/2 family.

1379910:TH63 RS16310
gene id: 1379910:TH63_RS16310
uniprot id: A0A0H4VSS9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

1379910:TH63 RS08475
gene id: 1379910:TH63_RS08475
uniprot id: A0A0H4VUI8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1379910:TH63 RS17885
gene id: 1379910:TH63_RS17885
uniprot id: A0A0H4VT44
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1379910:TH63 RS11215
gene id: 1379910:TH63_RS11215
uniprot id: A0A0H4VL76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1379910:TH63 RS05475
gene id: 1379910:TH63_RS05475
uniprot id: A0A0H4W462
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1379910:TH63 RS19325
gene id: 1379910:TH63_RS19325
uniprot id: A0A0H4VPS4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1379910:TH63 RS17450
gene id: 1379910:TH63_RS17450
uniprot id: A0A0H4VT84
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS15800
gene id: 1379910:TH63_RS15800
uniprot id: A0A0H4VSL5
names: Similarity
messages: Belongs to the BshC family.

1379910:TH63 RS07845
gene id: 1379910:TH63_RS07845
uniprot id: A0A0H4W5B1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS01710
gene id: 1379910:TH63_RS01710
uniprot id: A0A0H4W2G8
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1379910:TH63 RS09975
gene id: 1379910:TH63_RS09975
uniprot id: A0A0H4VUV8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS12910
gene id: 1379910:TH63_RS12910
uniprot id: A0A0H4VLV6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1379910:TH63 RS14980
gene id: 1379910:TH63_RS14980
uniprot id: A0A0H4VLG6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1379910:TH63 RS05580
gene id: 1379910:TH63_RS05580
uniprot id: A0A0H4VNB0
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1379910:TH63 RS04070
gene id: 1379910:TH63_RS04070
uniprot id: A0A0H4W3H1
names: Similarity
messages: Belongs to the peptidase S9C family.

1379910:TH63 RS08500
gene id: 1379910:TH63_RS08500
uniprot id: A0A0H4VPN8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS11055
gene id: 1379910:TH63_RS11055
uniprot id: A0A0H4VQQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1379910:TH63 RS11155
gene id: 1379910:TH63_RS11155
uniprot id: A0A0H4VQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1379910:TH63 RS05215
gene id: 1379910:TH63_RS05215
uniprot id: A0A0H4VMS2
names: Similarity
messages: Belongs to the peptidase M1 family.

1379910:TH63 RS05635
gene id: 1379910:TH63_RS05635
uniprot id: A0A0H4VNC0
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS11345
gene id: 1379910:TH63_RS11345
uniprot id: A0A0H4W6Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1379910:TH63 RS14065
gene id: 1379910:TH63_RS14065
uniprot id: A0A0H4VV66
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.

1379910:TH63 RS00645
gene id: 1379910:TH63_RS00645
uniprot id: A0A0H4VGR7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS11960
gene id: 1379910:TH63_RS11960
uniprot id: A0A0H4WB06
names: Similarity
messages: Belongs to the sulfatase family.

1379910:TH63 RS04265
gene id: 1379910:TH63_RS04265
uniprot id: A0A0H4VI24
names: Similarity
messages: Belongs to the AAA ATPase family.

1379910:TH63 RS00990
gene id: 1379910:TH63_RS00990
uniprot id: A0A0H4VKW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1379910:TH63 RS02630
gene id: 1379910:TH63_RS02630
uniprot id: A0A0H4VLI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1379910:TH63 RS02760
gene id: 1379910:TH63_RS02760
uniprot id: A0A0H4VM18
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1379910:TH63 RS14690
gene id: 1379910:TH63_RS14690
uniprot id: A0A0H4VLD2
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1379910:TH63 RS05625
gene id: 1379910:TH63_RS05625
uniprot id: A0A0H4VMY3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS19130
gene id: 1379910:TH63_RS19130
uniprot id: A0A0H4VMZ0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1379910:TH63 RS09995
gene id: 1379910:TH63_RS09995
uniprot id: A0A0H4VJA1
names: Similarity
messages: Belongs to the type IA topoisomerase family.

1379910:TH63 RS03580
gene id: 1379910:TH63_RS03580
uniprot id: A0A0H4VHU2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1379910:TH63 RS07275
gene id: 1379910:TH63_RS07275
uniprot id: A0A0H4VIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1379910:TH63 RS18325
gene id: 1379910:TH63_RS18325
uniprot id: A0A0H4W9M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS06265
gene id: 1379910:TH63_RS06265
uniprot id: A0A0H4VHY5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05855
gene id: 1379910:TH63_RS05855
uniprot id: A0A0H4VHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

1379910:TH63 RS07230
gene id: 1379910:TH63_RS07230
uniprot id: A0A0H4VNN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1379910:TH63 RS12150
gene id: 1379910:TH63_RS12150
uniprot id: A0A0H4VK82
names: Similarity
messages: Belongs to the peptidase S41A family.

1379910:TH63 RS06115
gene id: 1379910:TH63_RS06115
uniprot id: A0A0H4VN64
names: Similarity
messages: Belongs to the ParB family.

1379910:TH63 RS09825
gene id: 1379910:TH63_RS09825
uniprot id: A0A0H4VQ64
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS08350
gene id: 1379910:TH63_RS08350
uniprot id: A0A0H4VIN9
names: Similarity
messages: Belongs to the DEAD box helicase family.

1379910:TH63 RS07150
gene id: 1379910:TH63_RS07150
uniprot id: A0A0H4VJB7
names: Similarity
messages: Belongs to the peptidase S8 family.

1379910:TH63 RS12185
gene id: 1379910:TH63_RS12185
uniprot id: A0A0H4VR40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS15325
gene id: 1379910:TH63_RS15325
uniprot id: A0A0H4W8B5
names: Similarity
messages: Belongs to the histone deacetylase family.

1379910:TH63 RS14515
gene id: 1379910:TH63_RS14515
uniprot id: A0A0H4VS37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1379910:TH63 RS04400
gene id: 1379910:TH63_RS04400
uniprot id: A0A0H4VH82
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS06935
gene id: 1379910:TH63_RS06935
uniprot id: A0A0H4VNZ5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1379910:TH63 RS01170
gene id: 1379910:TH63_RS01170
uniprot id: A0A0H4VGZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1379910:TH63 RS07360
gene id: 1379910:TH63_RS07360
uniprot id: A0A0H4VIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1379910:TH63 RS08260
gene id: 1379910:TH63_RS08260
uniprot id: A0A0H4VJW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1379910:TH63 RS09600
gene id: 1379910:TH63_RS09600
uniprot id: A0A0H4W5Y0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1379910:TH63 RS00750
gene id: 1379910:TH63_RS00750
uniprot id: A0A0H4W221
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1379910:TH63 RS15885
gene id: 1379910:TH63_RS15885
uniprot id: A0A0H4VSM4
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

1379910:TH63 RS06475
gene id: 1379910:TH63_RS06475
uniprot id: A0A0H4VIZ9
names: Similarity
messages: Belongs to the pyruvate kinase family.

1379910:TH63 RS01055
gene id: 1379910:TH63_RS01055
uniprot id: A0A0H4VFZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1379910:TH63 RS06885
gene id: 1379910:TH63_RS06885
uniprot id: A0A0H4VNW2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1379910:TH63 RS10535
gene id: 1379910:TH63_RS10535
uniprot id: A0A0H4W6B8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1379910:TH63 RS10775
gene id: 1379910:TH63_RS10775
uniprot id: A0A0H4WAX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

1379910:TH63 RS14080
gene id: 1379910:TH63_RS14080
uniprot id: A0A0H4VRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS05495
gene id: 1379910:TH63_RS05495
uniprot id: A0A0H4VHN4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1379910:TH63 RS07105
gene id: 1379910:TH63_RS07105
uniprot id: A0A0H4W4V4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1379910:TH63 RS01430
gene id: 1379910:TH63_RS01430
uniprot id: A0A0H4W2D8
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1379910:TH63 RS17240
gene id: 1379910:TH63_RS17240
uniprot id: A0A0H4VSQ3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01860
gene id: 1379910:TH63_RS01860
uniprot id: A0A0H4W2J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS06665
gene id: 1379910:TH63_RS06665
uniprot id: A0A0H4VJ30
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

1379910:TH63 RS01200
gene id: 1379910:TH63_RS01200
uniprot id: A0A0H4VLD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1379910:TH63 RS06560
gene id: 1379910:TH63_RS06560
uniprot id: A0A0H4VNE2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05410
gene id: 1379910:TH63_RS05410
uniprot id: A0A0H4W452
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00140
gene id: 1379910:TH63_RS00140
uniprot id: A0A0H4VGJ2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1379910:TH63 RS07715
gene id: 1379910:TH63_RS07715
uniprot id: A0A0H4W592
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS19695
gene id: 1379910:TH63_RS19695
uniprot id: A0A0H4WA64
names: Similarity
messages: Belongs to the peptidase S41A family.

1379910:TH63 RS16660
gene id: 1379910:TH63_RS16660
uniprot id: A0A0H4W8W9
names: Similarity
messages: Belongs to the pirin family.

1379910:TH63 RS07595
gene id: 1379910:TH63_RS07595
uniprot id: A0A0H4W541
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS14985
gene id: 1379910:TH63_RS14985
uniprot id: A0A0H4W872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS17750
gene id: 1379910:TH63_RS17750
uniprot id: A0A0H4VP40
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1379910:TH63 RS14630
gene id: 1379910:TH63_RS14630
uniprot id: A0A0H4VRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1379910:TH63 RS01070
gene id: 1379910:TH63_RS01070
uniprot id: A0A0H4VGX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1379910:TH63 RS10360
gene id: 1379910:TH63_RS10360
uniprot id: A0A0H4VQL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

1379910:TH63 RS17470
gene id: 1379910:TH63_RS17470
uniprot id: A0A0H4VSV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1379910:TH63 RS13890
gene id: 1379910:TH63_RS13890
uniprot id: A0A0H4W7P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1379910:TH63 RS19570
gene id: 1379910:TH63_RS19570
uniprot id: A0A0H4VN57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

1379910:TH63 RS07925
gene id: 1379910:TH63_RS07925
uniprot id: A0A0H4VII8
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1379910:TH63 RS12365
gene id: 1379910:TH63_RS12365
uniprot id: A0A0H4VKB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1379910:TH63 RS16875
gene id: 1379910:TH63_RS16875
uniprot id: A0A0H4W8Z8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1379910:TH63 RS01540
gene id: 1379910:TH63_RS01540
uniprot id: A0A0H4VLI2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1379910:TH63 RS10265
gene id: 1379910:TH63_RS10265
uniprot id: A0A0H4VKT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS17905
gene id: 1379910:TH63_RS17905
uniprot id: A0A0H4VMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

1379910:TH63 RS11140
gene id: 1379910:TH63_RS11140
uniprot id: A0A0H4VQQ4
names: Similarity
messages: Belongs to the arginase family.

1379910:TH63 RS02210
gene id: 1379910:TH63_RS02210
uniprot id: A0A0H4W2N7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1379910:TH63 RS08570
gene id: 1379910:TH63_RS08570
uniprot id: A0A0H4VK13
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1379910:TH63 RS02315
gene id: 1379910:TH63_RS02315
uniprot id: A0A0H4VLD3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

1379910:TH63 RS12310
gene id: 1379910:TH63_RS12310
uniprot id: A0A0H4VQK0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1379910:TH63 RS17085
gene id: 1379910:TH63_RS17085
uniprot id: A0A0H4W938
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1379910:TH63 RS12405
gene id: 1379910:TH63_RS12405
uniprot id: A0A0H4W736
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS06810
gene id: 1379910:TH63_RS06810
uniprot id: A0A0H4VNV0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1379910:TH63 RS19490
gene id: 1379910:TH63_RS19490
uniprot id: A0A0H4WA32
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS00255
gene id: 1379910:TH63_RS00255
uniprot id: A0A0H4VFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1379910:TH63 RS12675
gene id: 1379910:TH63_RS12675
uniprot id: A0A0H4VRA4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1379910:TH63 RS04980
gene id: 1379910:TH63_RS04980
uniprot id: A0A0H4VIE2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1379910:TH63 RS08275
gene id: 1379910:TH63_RS08275
uniprot id: A0A0H4W5G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

1379910:TH63 RS17820
gene id: 1379910:TH63_RS17820
uniprot id: A0A0H4VP50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS14340
gene id: 1379910:TH63_RS14340
uniprot id: A0A0H4VL62
names: Similarity
messages: Belongs to the UPF0758 family.

1379910:TH63 RS13875
gene id: 1379910:TH63_RS13875
uniprot id: A0A0H4VMB2
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1379910:TH63 RS06230
gene id: 1379910:TH63_RS06230
uniprot id: A0A0H4VUL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

1379910:TH63 RS07955
gene id: 1379910:TH63_RS07955
uniprot id: A0A0H4W5D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1379910:TH63 RS13810
gene id: 1379910:TH63_RS13810
uniprot id: A0A0H4VMA5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1379910:TH63 RS11635
gene id: 1379910:TH63_RS11635
uniprot id: A0A0H4VK17
names: Similarity
messages: Belongs to the peptidase M13 family.

1379910:TH63 RS02090
gene id: 1379910:TH63_RS02090
uniprot id: A0A0H4VHB7
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS06595
gene id: 1379910:TH63_RS06595
uniprot id: A0A0H4WAL3
names: Subcellular Location Annotation
messages: Nucleus

1379910:TH63 RS14290
gene id: 1379910:TH63_RS14290
uniprot id: A0A0H4VRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1379910:TH63 RS17580
gene id: 1379910:TH63_RS17580
uniprot id: A0A0H4VSW5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1379910:TH63 RS05995
gene id: 1379910:TH63_RS05995
uniprot id: A0A0H4VNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS17270
gene id: 1379910:TH63_RS17270
uniprot id: A0A0H4VV32
names: Similarity
messages: Belongs to the AIR synthase family.

1379910:TH63 RS05185
gene id: 1379910:TH63_RS05185
uniprot id: A0A0H4WAI9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS15770
gene id: 1379910:TH63_RS15770
uniprot id: A0A0H4W8H3
names: Similarity
messages: Belongs to the AHA1 family.

1379910:TH63 RS16855
gene id: 1379910:TH63_RS16855
uniprot id: A0A0H4VSI0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1379910:TH63 RS08400
gene id: 1379910:TH63_RS08400
uniprot id: A0A0H4VPM7
names: Similarity
messages: Belongs to the pirin family.

1379910:TH63 RS19530
gene id: 1379910:TH63_RS19530
uniprot id: A0A0H4VPV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1379910:TH63 RS18845
gene id: 1379910:TH63_RS18845
uniprot id: A0A0H4VTV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1379910:TH63 RS15590
gene id: 1379910:TH63_RS15590
uniprot id: A0A0H4VN32
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1379910:TH63 RS13780
gene id: 1379910:TH63_RS13780
uniprot id: A0A0H4VKX9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

1379910:TH63 RS09015
gene id: 1379910:TH63_RS09015
uniprot id: A0A0H4VPA1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

1379910:TH63 RS14605
gene id: 1379910:TH63_RS14605
uniprot id: A0A0H4VMP2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1379910:TH63 RS08005
gene id: 1379910:TH63_RS08005
uniprot id: A0A0H4VUP1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1379910:TH63 RS13685
gene id: 1379910:TH63_RS13685
uniprot id: A0A0H4VM89
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1379910:TH63 RS08015
gene id: 1379910:TH63_RS08015
uniprot id: A0A0H4VPH3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1379910:TH63 RS13885
gene id: 1379910:TH63_RS13885
uniprot id: A0A0H4VKZ3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1379910:TH63 RS09580
gene id: 1379910:TH63_RS09580
uniprot id: A0A0H4VPG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1379910:TH63 RS14500
gene id: 1379910:TH63_RS14500
uniprot id: A0A0H4W827
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

1379910:TH63 RS09100
gene id: 1379910:TH63_RS09100
uniprot id: A0A0H4W5S8
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1379910:TH63 RS02255
gene id: 1379910:TH63_RS02255
uniprot id: A0A0H4VLW1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1379910:TH63 RS17595
gene id: 1379910:TH63_RS17595
uniprot id: A0A0H4VMF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1379910:TH63 RS17795
gene id: 1379910:TH63_RS17795
uniprot id: A0A0H4VTF6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1379910:TH63 RS09170
gene id: 1379910:TH63_RS09170
uniprot id: A0A0H4VPC0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS14225
gene id: 1379910:TH63_RS14225
uniprot id: A0A0H4VL44
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1379910:TH63 RS11700
gene id: 1379910:TH63_RS11700
uniprot id: A0A0H4WB00
names: Subcellular Location Annotation
messages: Cytoplasm

1379910:TH63 RS14040
gene id: 1379910:TH63_RS14040
uniprot id: A0A0H4VMD8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1379910:TH63 RS11385
gene id: 1379910:TH63_RS11385
uniprot id: A0A0H4VJY4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1379910:TH63 RS15045
gene id: 1379910:TH63_RS15045
uniprot id: A0A0H4W877
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS05120
gene id: 1379910:TH63_RS05120
uniprot id: A0A0H4VHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1379910:TH63 RS00560
gene id: 1379910:TH63_RS00560
uniprot id: A0A0H4VGR0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1379910:TH63 RS11395
gene id: 1379910:TH63_RS11395
uniprot id: A0A0H4VQA7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1379910:TH63 RS10530
gene id: 1379910:TH63_RS10530
uniprot id: A0A0H4VJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1379910:TH63 RS14495
gene id: 1379910:TH63_RS14495
uniprot id: A0A0H4VLB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

1379910:TH63 RS03460
gene id: 1379910:TH63_RS03460
uniprot id: A0A0H4VLU8
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

1379910:TH63 RS09830
gene id: 1379910:TH63_RS09830
uniprot id: A0A0H4VJ78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS14920
gene id: 1379910:TH63_RS14920
uniprot id: A0A0H4VLG0
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

1379910:TH63 RS11265
gene id: 1379910:TH63_RS11265
uniprot id: A0A0H4VQ98
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1379910:TH63 RS01775
gene id: 1379910:TH63_RS01775
uniprot id: A0A0H4W2H9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1379910:TH63 RS01985
gene id: 1379910:TH63_RS01985
uniprot id: A0A0H4VGF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1379910:TH63 RS09530
gene id: 1379910:TH63_RS09530
uniprot id: A0A0H4VKF2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

1379910:TH63 RS18760
gene id: 1379910:TH63_RS18760
uniprot id: A0A0H4W9S5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS04645
gene id: 1379910:TH63_RS04645
uniprot id: A0A0H4VIB5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS00475
gene id: 1379910:TH63_RS00475
uniprot id: A0A0H4VFQ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1379910:TH63 RS04690
gene id: 1379910:TH63_RS04690
uniprot id: A0A0H4W3V6
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS12620
gene id: 1379910:TH63_RS12620
uniprot id: A0A0H4VKE9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1379910:TH63 RS01160
gene id: 1379910:TH63_RS01160
uniprot id: A0A0H4W283
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1379910:TH63 RS10615
gene id: 1379910:TH63_RS10615
uniprot id: A0A0H4W6D5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS07540
gene id: 1379910:TH63_RS07540
uniprot id: A0A0H4W531
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08430
gene id: 1379910:TH63_RS08430
uniprot id: A0A0H4VPN2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Belongs to the spermidine/spermine synthase family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Homodimer or homotetramer.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1379910:TH63 RS17425
gene id: 1379910:TH63_RS17425
uniprot id: A0A0H4VT80
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01450
gene id: 1379910:TH63_RS01450
uniprot id: A0A0H4VG92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1379910:TH63 RS14155
gene id: 1379910:TH63_RS14155
uniprot id: A0A0H4VMF3
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS06510
gene id: 1379910:TH63_RS06510
uniprot id: A0A0H4VND2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS05535
gene id: 1379910:TH63_RS05535
uniprot id: A0A0H4VIJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1379910:TH63 RS00745
gene id: 1379910:TH63_RS00745
uniprot id: A0A0H4VFU2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1379910:TH63 RS00540
gene id: 1379910:TH63_RS00540
uniprot id: A0A0H4VL12
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

1379910:TH63 RS11280
gene id: 1379910:TH63_RS11280
uniprot id: A0A0H4VQS4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS10305
gene id: 1379910:TH63_RS10305
uniprot id: A0A0H4VKT3
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1379910:TH63 RS01255
gene id: 1379910:TH63_RS01255
uniprot id: A0A0H4VG68
names: Similarity
messages: Belongs to the heat shock protein 70 family.

1379910:TH63 RS11515
gene id: 1379910:TH63_RS11515
uniprot id: A0A0H4VLB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS13105
gene id: 1379910:TH63_RS13105
uniprot id: A0A0H4W7E1
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1379910:TH63 RS05280
gene id: 1379910:TH63_RS05280
uniprot id: A0A0H4VMT0
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

1379910:TH63 RS18950
gene id: 1379910:TH63_RS18950
uniprot id: A0A0H4VTW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS12330
gene id: 1379910:TH63_RS12330
uniprot id: A0A0H4VP27
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1379910:TH63 RS15610
gene id: 1379910:TH63_RS15610
uniprot id: A0A0H4VRY9
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

1379910:TH63 RS02710
gene id: 1379910:TH63_RS02710
uniprot id: A0A0H4VGP8
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1379910:TH63 RS01035
gene id: 1379910:TH63_RS01035
uniprot id: A0A0H4W258
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1379910:TH63 RS08700
gene id: 1379910:TH63_RS08700
uniprot id: A0A0H4VK34
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS07875
gene id: 1379910:TH63_RS07875
uniprot id: A0A0H4W5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1379910:TH63 RS01215
gene id: 1379910:TH63_RS01215
uniprot id: A0A0H4VL11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1379910:TH63 RS07195
gene id: 1379910:TH63_RS07195
uniprot id: A0A0H4VNM7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS12835
gene id: 1379910:TH63_RS12835
uniprot id: A0A0H4VQT0
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1379910:TH63 RS18980
gene id: 1379910:TH63_RS18980
uniprot id: A0A0H4W9V1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1379910:TH63 RS09630
gene id: 1379910:TH63_RS09630
uniprot id: A0A0H4VJ50
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1379910:TH63 RS08980
gene id: 1379910:TH63_RS08980
uniprot id: A0A0H4VP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS13790
gene id: 1379910:TH63_RS13790
uniprot id: A0A0H4W7N2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS09215
gene id: 1379910:TH63_RS09215
uniprot id: A0A0H4WAT8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1379910:TH63 RS01185
gene id: 1379910:TH63_RS01185
uniprot id: A0A0H4W2A8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1379910:TH63 RS12210
gene id: 1379910:TH63_RS12210
uniprot id: A0A0H4VQI8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1379910:TH63 RS02505
gene id: 1379910:TH63_RS02505
uniprot id: A0A0H4VLY9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1379910:TH63 RS17635
gene id: 1379910:TH63_RS17635
uniprot id: A0A0H4W9D0
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1379910:TH63 RS17685
gene id: 1379910:TH63_RS17685
uniprot id: A0A0H4W9D3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1379910:TH63 RS19795
gene id: 1379910:TH63_RS19795
uniprot id: A0A0H4W5I3
names: Similarity
messages: Belongs to the peptidase S8 family.

1379910:TH63 RS10480
gene id: 1379910:TH63_RS10480
uniprot id: A0A0H4VPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1379910:TH63 RS07035
gene id: 1379910:TH63_RS07035
uniprot id: A0A0H4VI79
names: Similarity
messages: Belongs to the type IB topoisomerase family.

1379910:TH63 RS07805
gene id: 1379910:TH63_RS07805
uniprot id: A0A0H4VJP8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS19335
gene id: 1379910:TH63_RS19335
uniprot id: A0A0H4VN20
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1379910:TH63 RS10475
gene id: 1379910:TH63_RS10475
uniprot id: A0A0H4W6A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1379910:TH63 RS11235
gene id: 1379910:TH63_RS11235
uniprot id: A0A0H4VQ94
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1379910:TH63 RS14190
gene id: 1379910:TH63_RS14190
uniprot id: A0A0H4VMF7
names: Similarity
messages: Belongs to the CvfB family.

1379910:TH63 RS16330
gene id: 1379910:TH63_RS16330
uniprot id: A0A0H4VNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1379910:TH63 RS17610
gene id: 1379910:TH63_RS17610
uniprot id: A0A0H4VSX0
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1379910:TH63 RS10215
gene id: 1379910:TH63_RS10215
uniprot id: A0A0H4VQB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1379910:TH63 RS09680
gene id: 1379910:TH63_RS09680
uniprot id: A0A0H4VKH8
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1379910:TH63 RS07450
gene id: 1379910:TH63_RS07450
uniprot id: A0A0H4VP64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1379910:TH63 RS16425
gene id: 1379910:TH63_RS16425
uniprot id: A0A0H4VNH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS00680
gene id: 1379910:TH63_RS00680
uniprot id: A0A0H4VKR7
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS06250
gene id: 1379910:TH63_RS06250
uniprot id: A0A0H4VNN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

1379910:TH63 RS06770
gene id: 1379910:TH63_RS06770
uniprot id: A0A0H4W4Q5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1379910:TH63 RS12695
gene id: 1379910:TH63_RS12695
uniprot id: A0A0H4VLS0
names: Similarity
messages: Belongs to the IMPACT family.

1379910:TH63 RS04765
gene id: 1379910:TH63_RS04765
uniprot id: A0A0H4VML0
names: Similarity
messages: Belongs to the peptidase S66 family.

1379910:TH63 RS06105
gene id: 1379910:TH63_RS06105
uniprot id: A0A0H4W4G0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1379910:TH63 RS06130
gene id: 1379910:TH63_RS06130
uniprot id: A0A0H4VHW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1379910:TH63 RS05295
gene id: 1379910:TH63_RS05295
uniprot id: A0A0H4VHK9
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS05090
gene id: 1379910:TH63_RS05090
uniprot id: A0A0H4VHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS04420
gene id: 1379910:TH63_RS04420
uniprot id: A0A0H4VI50
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.

1379910:TH63 RS11390
gene id: 1379910:TH63_RS11390
uniprot id: A0A0H4W6Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1379910:TH63 RS02300
gene id: 1379910:TH63_RS02300
uniprot id: A0A0H4VQ46
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1379910:TH63 RS13135
gene id: 1379910:TH63_RS13135
uniprot id: A0A0H4WB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

1379910:TH63 RS16505
gene id: 1379910:TH63_RS16505
uniprot id: A0A0H4VSD8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1379910:TH63 RS06135
gene id: 1379910:TH63_RS06135
uniprot id: A0A0H4W4G4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS14350
gene id: 1379910:TH63_RS14350
uniprot id: A0A0H4VV69
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1379910:TH63 RS15355
gene id: 1379910:TH63_RS15355
uniprot id: A0A0H4VLL4
names: Similarity
messages: Belongs to the peptidase C40 family.

1379910:TH63 RS14030
gene id: 1379910:TH63_RS14030
uniprot id: A0A0H4VRC2
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

1379910:TH63 RS10715
gene id: 1379910:TH63_RS10715
uniprot id: A0A0H4VKZ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1379910:TH63 RS01705
gene id: 1379910:TH63_RS01705
uniprot id: A0A0H4VGB6
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1379910:TH63 RS04780
gene id: 1379910:TH63_RS04780
uniprot id: A0A0H4VHF0
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS12435
gene id: 1379910:TH63_RS12435
uniprot id: A0A0H4VV12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1379910:TH63 RS14640
gene id: 1379910:TH63_RS14640
uniprot id: A0A0H4VS45
names: Similarity
messages: Belongs to the peptidase M16 family.

1379910:TH63 RS06740
gene id: 1379910:TH63_RS06740
uniprot id: A0A0H4VNG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS02240
gene id: 1379910:TH63_RS02240
uniprot id: A0A0H4W2P1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1379910:TH63 RS01575
gene id: 1379910:TH63_RS01575
uniprot id: A0A0H4VGA3
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS03945
gene id: 1379910:TH63_RS03945
uniprot id: A0A0H4VM46
names: Similarity
messages: Belongs to the SCO1/2 family.

1379910:TH63 RS18045
gene id: 1379910:TH63_RS18045
uniprot id: A0A0H4VPG4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

1379910:TH63 RS10490
gene id: 1379910:TH63_RS10490
uniprot id: A0A0H4VQF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1379910:TH63 RS04550
gene id: 1379910:TH63_RS04550
uniprot id: A0A0H4VMV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

1379910:TH63 RS16400
gene id: 1379910:TH63_RS16400
uniprot id: A0A0H4VSU4
names: Similarity
messages: Belongs to the Skp family.

1379910:TH63 RS03475
gene id: 1379910:TH63_RS03475
uniprot id: A0A0H4WAG0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

1379910:TH63 RS03560
gene id: 1379910:TH63_RS03560
uniprot id: A0A0H4VMD0
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1379910:TH63 RS17175
gene id: 1379910:TH63_RS17175
uniprot id: A0A0H4VSP1
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08650
gene id: 1379910:TH63_RS08650
uniprot id: A0A0H4W5L6
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS06305
gene id: 1379910:TH63_RS06305
uniprot id: A0A0H4VHY9
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1379910:TH63 RS06220
gene id: 1379910:TH63_RS06220
uniprot id: A0A0H4W4H9
names: Similarity
messages: Belongs to the peptidase C40 family.

1379910:TH63 RS16210
gene id: 1379910:TH63_RS16210
uniprot id: A0A0H4VS93
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

1379910:TH63 RS00095
gene id: 1379910:TH63_RS00095
uniprot id: A0A0H4W1V2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1379910:TH63 RS00080
gene id: 1379910:TH63_RS00080
uniprot id: A0A0H4VFK4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1379910:TH63 RS08415
gene id: 1379910:TH63_RS08415
uniprot id: A0A0H4VP33
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1379910:TH63 RS17950
gene id: 1379910:TH63_RS17950
uniprot id: A0A0H4VP70
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1379910:TH63 RS02695
gene id: 1379910:TH63_RS02695
uniprot id: A0A0H4VLJ6
names: Similarity
messages: Belongs to the asparagine synthetase family.

1379910:TH63 RS02175
gene id: 1379910:TH63_RS02175
uniprot id: A0A0H4VGH5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1379910:TH63 RS13430
gene id: 1379910:TH63_RS13430
uniprot id: A0A0H4VKR8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1379910:TH63 RS11985
gene id: 1379910:TH63_RS11985
uniprot id: A0A0H4VQG6
names: Similarity
messages: Belongs to the sulfatase family.

1379910:TH63 RS03095
gene id: 1379910:TH63_RS03095
uniprot id: A0A0H4W314
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS16865
gene id: 1379910:TH63_RS16865
uniprot id: A0A0H4VT08
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1379910:TH63 RS02580
gene id: 1379910:TH63_RS02580
uniprot id: A0A0H4VLZ6
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

1379910:TH63 RS13075
gene id: 1379910:TH63_RS13075
uniprot id: A0A0H4VQW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1379910:TH63 RS01440
gene id: 1379910:TH63_RS01440
uniprot id: A0A0H4VH56
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1379910:TH63 RS13745
gene id: 1379910:TH63_RS13745
uniprot id: A0A0H4VRN8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1379910:TH63 RS08705
gene id: 1379910:TH63_RS08705
uniprot id: A0A0H4VPR5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS14760
gene id: 1379910:TH63_RS14760
uniprot id: A0A0H4W848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1379910:TH63 RS06745
gene id: 1379910:TH63_RS06745
uniprot id: A0A0H4VJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

1379910:TH63 RS11560
gene id: 1379910:TH63_RS11560
uniprot id: A0A0H4W6S9
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15155
gene id: 1379910:TH63_RS15155
uniprot id: A0A0H4VMV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

1379910:TH63 RS07720
gene id: 1379910:TH63_RS07720
uniprot id: A0A0H4VNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

1379910:TH63 RS05905
gene id: 1379910:TH63_RS05905
uniprot id: A0A0H4VIP3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

1379910:TH63 RS05545
gene id: 1379910:TH63_RS05545
uniprot id: A0A0H4VHP2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1379910:TH63 RS06790
gene id: 1379910:TH63_RS06790
uniprot id: A0A0H4VI53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS01040
gene id: 1379910:TH63_RS01040
uniprot id: A0A0H4VKW5
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1379910:TH63 RS03650
gene id: 1379910:TH63_RS03650
uniprot id: A0A0H4VLY1
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

1379910:TH63 RS18875
gene id: 1379910:TH63_RS18875
uniprot id: A0A0H4VTV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1379910:TH63 RS05975
gene id: 1379910:TH63_RS05975
uniprot id: A0A0H4W4D8
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

1379910:TH63 RS10425
gene id: 1379910:TH63_RS10425
uniprot id: A0A0H4VPV1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1379910:TH63 RS12805
gene id: 1379910:TH63_RS12805
uniprot id: A0A0H4VKI0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS18415
gene id: 1379910:TH63_RS18415
uniprot id: A0A0H4VTB3
names: Similarity
messages: Belongs to the peptidase U62 family.

1379910:TH63 RS14720
gene id: 1379910:TH63_RS14720
uniprot id: A0A0H4W845
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

1379910:TH63 RS17730
gene id: 1379910:TH63_RS17730
uniprot id: A0A0H4VTE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1379910:TH63 RS15600
gene id: 1379910:TH63_RS15600
uniprot id: A0A0H4VLP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1379910:TH63 RS12580
gene id: 1379910:TH63_RS12580
uniprot id: A0A0H4VLQ1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1379910:TH63 RS05530
gene id: 1379910:TH63_RS05530
uniprot id: A0A0H4VMW8
names: Similarity
messages: Belongs to the peptidase M17 family.

1379910:TH63 RS07500
gene id: 1379910:TH63_RS07500
uniprot id: A0A0H4VIC7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

1379910:TH63 RS12605
gene id: 1379910:TH63_RS12605
uniprot id: A0A0H4VQQ3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

1379910:TH63 RS02705
gene id: 1379910:TH63_RS02705
uniprot id: A0A0H4VM12
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1379910:TH63 RS16890
gene id: 1379910:TH63_RS16890
uniprot id: A0A0H4VNP8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

1379910:TH63 RS16260
gene id: 1379910:TH63_RS16260
uniprot id: A0A0H4W8R2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1379910:TH63 RS00980
gene id: 1379910:TH63_RS00980
uniprot id: A0A0H4VFX9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1379910:TH63 RS15875
gene id: 1379910:TH63_RS15875
uniprot id: A0A0H4VS28
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1379910:TH63 RS19260
gene id: 1379910:TH63_RS19260
uniprot id: A0A0H4VN07
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1379910:TH63 RS16985
gene id: 1379910:TH63_RS16985
uniprot id: A0A0H4VM75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1379910:TH63 RS05465
gene id: 1379910:TH63_RS05465
uniprot id: A0A0H4VN87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS18695
gene id: 1379910:TH63_RS18695
uniprot id: A0A0H4VMT2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1379910:TH63 RS06025
gene id: 1379910:TH63_RS06025
uniprot id: A0A0H4VNH8
names: Similarity
messages: Belongs to the peptidase C40 family.

1379910:TH63 RS01475
gene id: 1379910:TH63_RS01475
uniprot id: A0A0H4VL41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1379910:TH63 RS02295
gene id: 1379910:TH63_RS02295
uniprot id: A0A0H4VGJ1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1379910:TH63 RS06585
gene id: 1379910:TH63_RS06585
uniprot id: A0A0H4W4N4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1379910:TH63 RS06705
gene id: 1379910:TH63_RS06705
uniprot id: A0A0H4VNG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS06155
gene id: 1379910:TH63_RS06155
uniprot id: A0A0H4VHW7
names: Similarity
messages: Belongs to the threonine aldolase family.

1379910:TH63 RS15175
gene id: 1379910:TH63_RS15175
uniprot id: A0A0H4W895
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1379910:TH63 RS19510
gene id: 1379910:TH63_RS19510
uniprot id: A0A0H4VN48
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1379910:TH63 RS11895
gene id: 1379910:TH63_RS11895
uniprot id: A0A0H4VR11
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS06365
gene id: 1379910:TH63_RS06365
uniprot id: A0A0H4VNM9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS12545
gene id: 1379910:TH63_RS12545
uniprot id: A0A0H4VLP6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1379910:TH63 RS17640
gene id: 1379910:TH63_RS17640
uniprot id: A0A0H4VV43
names: Subcellular Location Annotation
messages: Secreted

1379910:TH63 RS12400
gene id: 1379910:TH63_RS12400
uniprot id: A0A0H4VKB6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS07910
gene id: 1379910:TH63_RS07910
uniprot id: A0A0H4VNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS04270
gene id: 1379910:TH63_RS04270
uniprot id: A0A0H4VU66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1379910:TH63 RS04470
gene id: 1379910:TH63_RS04470
uniprot id: A0A0H4W3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS00615
gene id: 1379910:TH63_RS00615
uniprot id: A0A0H4W208
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1379910:TH63 RS18720
gene id: 1379910:TH63_RS18720
uniprot id: A0A0H4VPI3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

1379910:TH63 RS02585
gene id: 1379910:TH63_RS02585
uniprot id: A0A0H4VGM9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS12960
gene id: 1379910:TH63_RS12960
uniprot id: A0A0H4VQV3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1379910:TH63 RS08975
gene id: 1379910:TH63_RS08975
uniprot id: A0A0H4W5Q8
names: Similarity
messages: Belongs to the DtxR/MntR family.

1379910:TH63 RS05505
gene id: 1379910:TH63_RS05505
uniprot id: A0A0H4VMW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1379910:TH63 RS00420
gene id: 1379910:TH63_RS00420
uniprot id: A0A0H4W1Y8
names: Similarity
messages: Belongs to the aldose epimerase family.

1379910:TH63 RS00880
gene id: 1379910:TH63_RS00880
uniprot id: A0A0H4VUA9
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS18900
gene id: 1379910:TH63_RS18900
uniprot id: A0A0H4VTV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1379910:TH63 RS00285
gene id: 1379910:TH63_RS00285
uniprot id: A0A0H4VFM9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS17705
gene id: 1379910:TH63_RS17705
uniprot id: A0A0H4VTE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

1379910:TH63 RS09655
gene id: 1379910:TH63_RS09655
uniprot id: A0A0H4VJ56
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS18755
gene id: 1379910:TH63_RS18755
uniprot id: A0A0H4VMU0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS11325
gene id: 1379910:TH63_RS11325
uniprot id: A0A0H4VQA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS12600
gene id: 1379910:TH63_RS12600
uniprot id: A0A0H4W761
names: Similarity
messages: Belongs to the aspartokinase family.

1379910:TH63 RS16905
gene id: 1379910:TH63_RS16905
uniprot id: A0A0H4VPC3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1379910:TH63 RS19505
gene id: 1379910:TH63_RS19505
uniprot id: A0A0H4VU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS02510
gene id: 1379910:TH63_RS02510
uniprot id: A0A0H4VUE1
names: Similarity
messages: Belongs to the GARS family.

1379910:TH63 RS19110
gene id: 1379910:TH63_RS19110
uniprot id: A0A0H4VTJ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS01140
gene id: 1379910:TH63_RS01140
uniprot id: A0A0H4VKY7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1379910:TH63 RS06125
gene id: 1379910:TH63_RS06125
uniprot id: A0A0H4VNJ2
names: Similarity
messages: Belongs to the UPF0173 family.

1379910:TH63 RS13730
gene id: 1379910:TH63_RS13730
uniprot id: A0A0H4W7M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS12425
gene id: 1379910:TH63_RS12425
uniprot id: A0A0H4VKC1
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1379910:TH63 RS06070
gene id: 1379910:TH63_RS06070
uniprot id: A0A0H4W4F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1379910:TH63 RS06990
gene id: 1379910:TH63_RS06990
uniprot id: A0A0H4VP03
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1379910:TH63 RS05925
gene id: 1379910:TH63_RS05925
uniprot id: A0A0H4W4D2
names: Similarity
messages: Belongs to the ribF family.

1379910:TH63 RS13930
gene id: 1379910:TH63_RS13930
uniprot id: A0A0H4VUX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1379910:TH63 RS00580
gene id: 1379910:TH63_RS00580
uniprot id: A0A0H4W205
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1379910:TH63 RS12610
gene id: 1379910:TH63_RS12610
uniprot id: A0A0H4VLQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

1379910:TH63 RS13985
gene id: 1379910:TH63_RS13985
uniprot id: A0A0H4VRS0
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1379910:TH63 RS06170
gene id: 1379910:TH63_RS06170
uniprot id: A0A0H4VIT6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS17845
gene id: 1379910:TH63_RS17845
uniprot id: A0A0H4VT39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

1379910:TH63 RS12530
gene id: 1379910:TH63_RS12530
uniprot id: A0A0H4VKD6
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

1379910:TH63 RS01165
gene id: 1379910:TH63_RS01165
uniprot id: A0A0H4VKZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1379910:TH63 RS05500
gene id: 1379910:TH63_RS05500
uniprot id: A0A0H4W466
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1379910:TH63 RS17005
gene id: 1379910:TH63_RS17005
uniprot id: A0A0H4VT25
names: Similarity
messages: Belongs to the DinB family.

1379910:TH63 RS16255
gene id: 1379910:TH63_RS16255
uniprot id: A0A0H4VLY0
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

1379910:TH63 RS08575
gene id: 1379910:TH63_RS08575
uniprot id: A0A0H4VPP8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1379910:TH63 RS15540
gene id: 1379910:TH63_RS15540
uniprot id: A0A0H4VLN7
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00965
gene id: 1379910:TH63_RS00965
uniprot id: A0A0H4VKV5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS03250
gene id: 1379910:TH63_RS03250
uniprot id: A0A0H4W340
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS03775
gene id: 1379910:TH63_RS03775
uniprot id: A0A0H4VH20
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05695
gene id: 1379910:TH63_RS05695
uniprot id: A0A0H4VND0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1379910:TH63 RS04695
gene id: 1379910:TH63_RS04695
uniprot id: A0A0H4VMI8
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS05070
gene id: 1379910:TH63_RS05070
uniprot id: A0A0H4VMQ3
names: Similarity
messages: Belongs to the CapA family.

1379910:TH63 RS01095
gene id: 1379910:TH63_RS01095
uniprot id: A0A0H4VGY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1379910:TH63 RS01065
gene id: 1379910:TH63_RS01065
uniprot id: A0A0H4VKX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1379910:TH63 RS14075
gene id: 1379910:TH63_RS14075
uniprot id: A0A0H4VME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1379910:TH63 RS01220
gene id: 1379910:TH63_RS01220
uniprot id: A0A0H4VH38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1379910:TH63 RS14415
gene id: 1379910:TH63_RS14415
uniprot id: A0A0H4VRJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS15805
gene id: 1379910:TH63_RS15805
uniprot id: A0A0H4VLR7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

1379910:TH63 RS09590
gene id: 1379910:TH63_RS09590
uniprot id: A0A0H4VQ29
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1379910:TH63 RS16320
gene id: 1379910:TH63_RS16320
uniprot id: A0A0H4W8S0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1379910:TH63 RS12275
gene id: 1379910:TH63_RS12275
uniprot id: A0A0H4W716
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS10605
gene id: 1379910:TH63_RS10605
uniprot id: A0A0H4VJL0
names: Similarity
messages: Belongs to the sterol desaturase family.

1379910:TH63 RS13355
gene id: 1379910:TH63_RS13355
uniprot id: A0A0H4VRJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1379910:TH63 RS18250
gene id: 1379910:TH63_RS18250
uniprot id: A0A0H4VT91
names: Similarity
messages: Belongs to the AHA1 family.

1379910:TH63 RS00955
gene id: 1379910:TH63_RS00955
uniprot id: A0A0H4VFX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1379910:TH63 RS00125
gene id: 1379910:TH63_RS00125
uniprot id: A0A0H4VFK7
names: Similarity
messages: Belongs to the peptidase S66 family.

1379910:TH63 RS00500
gene id: 1379910:TH63_RS00500
uniprot id: A0A0H4VU94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

1379910:TH63 RS07740
gene id: 1379910:TH63_RS07740
uniprot id: A0A0H4WAN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1379910:TH63 RS00220
gene id: 1379910:TH63_RS00220
uniprot id: A0A0H4VKX0
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1379910:TH63 RS04395
gene id: 1379910:TH63_RS04395
uniprot id: A0A0H4VMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1379910:TH63 RS16950
gene id: 1379910:TH63_RS16950
uniprot id: A0A0H4VNQ9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1379910:TH63 RS01815
gene id: 1379910:TH63_RS01815
uniprot id: A0A0H4VLM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1379910:TH63 RS01570
gene id: 1379910:TH63_RS01570
uniprot id: A0A0H4VLI6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS10235
gene id: 1379910:TH63_RS10235
uniprot id: A0A0H4VKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Cell wall formation.
messages: Cytoplasm

1379910:TH63 RS12955
gene id: 1379910:TH63_RS12955
uniprot id: A0A0H4W7B6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1379910:TH63 RS07815
gene id: 1379910:TH63_RS07815
uniprot id: A0A0H4VIH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1379910:TH63 RS19645
gene id: 1379910:TH63_RS19645
uniprot id: A0A0H4VU72
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1379910:TH63 RS09845
gene id: 1379910:TH63_RS09845
uniprot id: A0A0H4VPM0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS12595
gene id: 1379910:TH63_RS12595
uniprot id: A0A0H4VKE4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS05620
gene id: 1379910:TH63_RS05620
uniprot id: A0A0H4W486
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1379910:TH63 RS09540
gene id: 1379910:TH63_RS09540
uniprot id: A0A0H4VJ38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS02540
gene id: 1379910:TH63_RS02540
uniprot id: A0A0H4VLZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1379910:TH63 RS09255
gene id: 1379910:TH63_RS09255
uniprot id: A0A0H4VPC4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

1379910:TH63 RS11620
gene id: 1379910:TH63_RS11620
uniprot id: A0A0H4VQY1
names: Similarity
messages: Belongs to the XseB family.

1379910:TH63 RS13635
gene id: 1379910:TH63_RS13635
uniprot id: A0A0H4VKV4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1379910:TH63 RS07950
gene id: 1379910:TH63_RS07950
uniprot id: A0A0H4VIJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1379910:TH63 RS17790
gene id: 1379910:TH63_RS17790
uniprot id: A0A0H4VR15
names: Similarity
messages: Belongs to the DinB family.

1379910:TH63 RS11010
gene id: 1379910:TH63_RS11010
uniprot id: A0A0H4W6J7
names: Similarity
messages: Belongs to the peptidase S49 family.

1379910:TH63 RS00440
gene id: 1379910:TH63_RS00440
uniprot id: A0A0H4VL01
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

1379910:TH63 RS16845
gene id: 1379910:TH63_RS16845
uniprot id: A0A0H4VM56
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

1379910:TH63 RS11655
gene id: 1379910:TH63_RS11655
uniprot id: A0A0H4VLC6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS01435
gene id: 1379910:TH63_RS01435
uniprot id: A0A0H4VL35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS07355
gene id: 1379910:TH63_RS07355
uniprot id: A0A0H4VP49
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1379910:TH63 RS02590
gene id: 1379910:TH63_RS02590
uniprot id: A0A0H4W2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1379910:TH63 RS03050
gene id: 1379910:TH63_RS03050
uniprot id: A0A0H4VGT8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1379910:TH63 RS02515
gene id: 1379910:TH63_RS02515
uniprot id: A0A0H4VNE3
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1379910:TH63 RS16975
gene id: 1379910:TH63_RS16975
uniprot id: A0A0H4VNR3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

1379910:TH63 RS03520
gene id: 1379910:TH63_RS03520
uniprot id: A0A0H4W378
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS08210
gene id: 1379910:TH63_RS08210
uniprot id: A0A0H4VPK0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1379910:TH63 RS18545
gene id: 1379910:TH63_RS18545
uniprot id: A0A0H4W9P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
messages: Membrane

1379910:TH63 RS05630
gene id: 1379910:TH63_RS05630
uniprot id: A0A0H4VIL2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS04425
gene id: 1379910:TH63_RS04425
uniprot id: A0A0H4VMQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1379910:TH63 RS01205
gene id: 1379910:TH63_RS01205
uniprot id: A0A0H4VG59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1379910:TH63 RS08140
gene id: 1379910:TH63_RS08140
uniprot id: A0A0H4VP07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS13855
gene id: 1379910:TH63_RS13855
uniprot id: A0A0H4VRQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS13165
gene id: 1379910:TH63_RS13165
uniprot id: A0A0H4W7E9
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1379910:TH63 RS06630
gene id: 1379910:TH63_RS06630
uniprot id: A0A0H4VNF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1379910:TH63 RS01330
gene id: 1379910:TH63_RS01330
uniprot id: A0A0H4W2C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1379910:TH63 RS12730
gene id: 1379910:TH63_RS12730
uniprot id: A0A0H4VLS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1379910:TH63 RS00785
gene id: 1379910:TH63_RS00785
uniprot id: A0A0H4W223
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS11665
gene id: 1379910:TH63_RS11665
uniprot id: A0A0H4VK22
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1379910:TH63 RS07550
gene id: 1379910:TH63_RS07550
uniprot id: A0A0H4VJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

1379910:TH63 RS11160
gene id: 1379910:TH63_RS11160
uniprot id: A0A0H4VL73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1379910:TH63 RS15410
gene id: 1379910:TH63_RS15410
uniprot id: A0A0H4W8C4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1379910:TH63 RS14120
gene id: 1379910:TH63_RS14120
uniprot id: A0A0H4W7T7
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS07135
gene id: 1379910:TH63_RS07135
uniprot id: A0A0H4VI88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1379910:TH63 RS01550
gene id: 1379910:TH63_RS01550
uniprot id: A0A0H4VGA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

1379910:TH63 RS17735
gene id: 1379910:TH63_RS17735
uniprot id: A0A0H4VMI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1379910:TH63 RS08290
gene id: 1379910:TH63_RS08290
uniprot id: A0A0H4VJW8
names: Similarity
messages: Belongs to the citrate synthase family.

1379910:TH63 RS12560
gene id: 1379910:TH63_RS12560
uniprot id: A0A0H4VKE0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS18240
gene id: 1379910:TH63_RS18240
uniprot id: A0A0H4W9L1
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

1379910:TH63 RS14725
gene id: 1379910:TH63_RS14725
uniprot id: A0A0H4VRQ3
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1379910:TH63 RS16045
gene id: 1379910:TH63_RS16045
uniprot id: A0A0H4VS70
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

1379910:TH63 RS11180
gene id: 1379910:TH63_RS11180
uniprot id: A0A0H4W6N4
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1379910:TH63 RS04195
gene id: 1379910:TH63_RS04195
uniprot id: A0A0H4VM88
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS02565
gene id: 1379910:TH63_RS02565
uniprot id: A0A0H4VHH5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS17165
gene id: 1379910:TH63_RS17165
uniprot id: A0A0H4VM99
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

1379910:TH63 RS14140
gene id: 1379910:TH63_RS14140
uniprot id: A0A0H4VL26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1379910:TH63 RS01045
gene id: 1379910:TH63_RS01045
uniprot id: A0A0H4VGX0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1379910:TH63 RS11525
gene id: 1379910:TH63_RS11525
uniprot id: A0A0H4VK03
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

1379910:TH63 RS07870
gene id: 1379910:TH63_RS07870
uniprot id: A0A0H4VII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1379910:TH63 RS18225
gene id: 1379910:TH63_RS18225
uniprot id: A0A0H4VPB3
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1379910:TH63 RS08270
gene id: 1379910:TH63_RS08270
uniprot id: A0A0H4VIN1
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1379910:TH63 RS14715
gene id: 1379910:TH63_RS14715
uniprot id: A0A0H4VLD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

1379910:TH63 RS01230
gene id: 1379910:TH63_RS01230
uniprot id: A0A0H4VG64
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1379910:TH63 RS07710
gene id: 1379910:TH63_RS07710
uniprot id: A0A0H4VIG2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS05540
gene id: 1379910:TH63_RS05540
uniprot id: A0A0H4VNA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1379910:TH63 RS01975
gene id: 1379910:TH63_RS01975
uniprot id: A0A0H4VHA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.
messages: Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.
messages: Homotrimer.

1379910:TH63 RS05095
gene id: 1379910:TH63_RS05095
uniprot id: A0A0H4W408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1379910:TH63 RS09090
gene id: 1379910:TH63_RS09090
uniprot id: A0A0H4VPW8
names: Similarity
messages: Belongs to the SUI1 family.

1379910:TH63 RS05705
gene id: 1379910:TH63_RS05705
uniprot id: A0A0H4W4A1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1379910:TH63 RS16515
gene id: 1379910:TH63_RS16515
uniprot id: A0A0H4VSW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1379910:TH63 RS01795
gene id: 1379910:TH63_RS01795
uniprot id: A0A0H4VGD0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00400
gene id: 1379910:TH63_RS00400
uniprot id: A0A0H4VKZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1379910:TH63 RS04675
gene id: 1379910:TH63_RS04675
uniprot id: A0A0H4VMX2
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS15815
gene id: 1379910:TH63_RS15815
uniprot id: A0A0H4VS20
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1379910:TH63 RS14020
gene id: 1379910:TH63_RS14020
uniprot id: A0A0H4VL05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1379910:TH63 RS07380
gene id: 1379910:TH63_RS07380
uniprot id: A0A0H4VJH4
names: Subunit
messages: Homodimer.

1379910:TH63 RS12235
gene id: 1379910:TH63_RS12235
uniprot id: A0A0H4W711
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

1379910:TH63 RS09570
gene id: 1379910:TH63_RS09570
uniprot id: A0A0H4VJ41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1379910:TH63 RS16215
gene id: 1379910:TH63_RS16215
uniprot id: A0A0H4VND4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

1379910:TH63 RS11785
gene id: 1379910:TH63_RS11785
uniprot id: A0A0H4W6V8
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

1379910:TH63 RS10440
gene id: 1379910:TH63_RS10440
uniprot id: A0A0H4VJI4
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1379910:TH63 RS08930
gene id: 1379910:TH63_RS08930
uniprot id: A0A0H4VK63
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS16920
gene id: 1379910:TH63_RS16920
uniprot id: A0A0H4VNQ4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1379910:TH63 RS10505
gene id: 1379910:TH63_RS10505
uniprot id: A0A0H4VPW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1379910:TH63 RS05235
gene id: 1379910:TH63_RS05235
uniprot id: A0A0H4VHJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1379910:TH63 RS07240
gene id: 1379910:TH63_RS07240
uniprot id: A0A0H4VP28
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1379910:TH63 RS02545
gene id: 1379910:TH63_RS02545
uniprot id: A0A0H4VGM4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

1379910:TH63 RS03585
gene id: 1379910:TH63_RS03585
uniprot id: A0A0H4VMD7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1379910:TH63 RS01105
gene id: 1379910:TH63_RS01105
uniprot id: A0A0H4VG02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1379910:TH63 RS04280
gene id: 1379910:TH63_RS04280
uniprot id: A0A0H4VQ79
names: Similarity
messages: Belongs to the AHA1 family.

1379910:TH63 RS10160
gene id: 1379910:TH63_RS10160
uniprot id: A0A0H4VQA5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1379910:TH63 RS07855
gene id: 1379910:TH63_RS07855
uniprot id: A0A0H4VJQ8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS08225
gene id: 1379910:TH63_RS08225
uniprot id: A0A0H4W5F8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1379910:TH63 RS03165
gene id: 1379910:TH63_RS03165
uniprot id: A0A0H4VLQ9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1379910:TH63 RS03270
gene id: 1379910:TH63_RS03270
uniprot id: A0A0H4VM80
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1379910:TH63 RS14100
gene id: 1379910:TH63_RS14100
uniprot id: A0A0H4VRD1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1379910:TH63 RS04050
gene id: 1379910:TH63_RS04050
uniprot id: A0A0H4VM65
names: Similarity
messages: Belongs to the DinB family.

1379910:TH63 RS05845
gene id: 1379910:TH63_RS05845
uniprot id: A0A0H4VUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1379910:TH63 RS05955
gene id: 1379910:TH63_RS05955
uniprot id: A0A0H4VN37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1379910:TH63 RS01120
gene id: 1379910:TH63_RS01120
uniprot id: A0A0H4VGY5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1379910:TH63 RS14010
gene id: 1379910:TH63_RS14010
uniprot id: A0A0H4VRS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1379910:TH63 RS07960
gene id: 1379910:TH63_RS07960
uniprot id: A0A0H4VNY8
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00205
gene id: 1379910:TH63_RS00205
uniprot id: A0A0H4VKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1379910:TH63 RS06395
gene id: 1379910:TH63_RS06395
uniprot id: A0A0H4VI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1379910:TH63 RS03755
gene id: 1379910:TH63_RS03755
uniprot id: A0A0H4W3B9
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS04555
gene id: 1379910:TH63_RS04555
uniprot id: A0A0H4VHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS01110
gene id: 1379910:TH63_RS01110
uniprot id: A0A0H4W271
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1379910:TH63 RS09550
gene id: 1379910:TH63_RS09550
uniprot id: A0A0H4VPF9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

1379910:TH63 RS06915
gene id: 1379910:TH63_RS06915
uniprot id: A0A0H4VI67
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS07435
gene id: 1379910:TH63_RS07435
uniprot id: A0A0H4W512
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1379910:TH63 RS00995
gene id: 1379910:TH63_RS00995
uniprot id: A0A0H4VGW7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS16635
gene id: 1379910:TH63_RS16635
uniprot id: A0A0H4VNK6
names: Similarity
messages: Belongs to the asparagine synthetase family.

1379910:TH63 RS02010
gene id: 1379910:TH63_RS02010
uniprot id: A0A0H4VHB0
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS03370
gene id: 1379910:TH63_RS03370
uniprot id: A0A0H4VM98
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1379910:TH63 RS01735
gene id: 1379910:TH63_RS01735
uniprot id: A0A0H4VLK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1379910:TH63 RS13955
gene id: 1379910:TH63_RS13955
uniprot id: A0A0H4VKZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1379910:TH63 RS08790
gene id: 1379910:TH63_RS08790
uniprot id: A0A0H4VIU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1379910:TH63 RS06055
gene id: 1379910:TH63_RS06055
uniprot id: A0A0H4VIR2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

1379910:TH63 RS02815
gene id: 1379910:TH63_RS02815
uniprot id: A0A0H4VGR4
names: Similarity
messages: Belongs to the asparagine synthetase family.

1379910:TH63 RS13010
gene id: 1379910:TH63_RS13010
uniprot id: A0A0H4VKK7
names: Similarity
messages: Belongs to the peptidase S9C family.

1379910:TH63 RS04465
gene id: 1379910:TH63_RS04465
uniprot id: A0A0H4VH90
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

1379910:TH63 RS04650
gene id: 1379910:TH63_RS04650
uniprot id: A0A0H4VMW6
names: Similarity
messages: Belongs to the UxaA family.

1379910:TH63 RS12895
gene id: 1379910:TH63_RS12895
uniprot id: A0A0H4VKI9
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS19555
gene id: 1379910:TH63_RS19555
uniprot id: A0A0H4VTS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1379910:TH63 RS02900
gene id: 1379910:TH63_RS02900
uniprot id: A0A0H4VHL7
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS15170
gene id: 1379910:TH63_RS15170
uniprot id: A0A0H4VV82
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1379910:TH63 RS17835
gene id: 1379910:TH63_RS17835
uniprot id: A0A0H4W9G4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1379910:TH63 RS00685
gene id: 1379910:TH63_RS00685
uniprot id: A0A0H4VGS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS19905
gene id: 1379910:TH63_RS19905
uniprot id: A0A0H4VI59
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1379910:TH63 RS10870
gene id: 1379910:TH63_RS10870
uniprot id: A0A0H4VL06
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1379910:TH63 RS02060
gene id: 1379910:TH63_RS02060
uniprot id: A0A0H4VLS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

1379910:TH63 RS06765
gene id: 1379910:TH63_RS06765
uniprot id: A0A0H4VI51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1379910:TH63 RS14735
gene id: 1379910:TH63_RS14735
uniprot id: A0A0H4VMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1379910:TH63 RS11170
gene id: 1379910:TH63_RS11170
uniprot id: A0A0H4VJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1379910:TH63 RS15825
gene id: 1379910:TH63_RS15825
uniprot id: A0A0H4VSL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1379910:TH63 RS19220
gene id: 1379910:TH63_RS19220
uniprot id: A0A0H4VTL2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1379910:TH63 RS02500
gene id: 1379910:TH63_RS02500
uniprot id: A0A0H4VHG6
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1379910:TH63 RS03735
gene id: 1379910:TH63_RS03735
uniprot id: A0A0H4VM02
names: Similarity
messages: Belongs to the universal stress protein A family.

1379910:TH63 RS15565
gene id: 1379910:TH63_RS15565
uniprot id: A0A0H4VSF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1379910:TH63 RS16785
gene id: 1379910:TH63_RS16785
uniprot id: A0A0H4VM49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS17300
gene id: 1379910:TH63_RS17300
uniprot id: A0A0H4VMB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS16500
gene id: 1379910:TH63_RS16500
uniprot id: A0A0H4W8U6
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS16275
gene id: 1379910:TH63_RS16275
uniprot id: A0A0H4VNE6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1379910:TH63 RS05305
gene id: 1379910:TH63_RS05305
uniprot id: A0A0H4VMT3
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

1379910:TH63 RS03205
gene id: 1379910:TH63_RS03205
uniprot id: A0A0H4VM68
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1379910:TH63 RS16745
gene id: 1379910:TH63_RS16745
uniprot id: A0A0H4VSZ2
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS01175
gene id: 1379910:TH63_RS01175
uniprot id: A0A0H4VLD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1379910:TH63 RS15640
gene id: 1379910:TH63_RS15640
uniprot id: A0A0H4VLP9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1379910:TH63 RS04045
gene id: 1379910:TH63_RS04045
uniprot id: A0A0H4W3G4
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS19600
gene id: 1379910:TH63_RS19600
uniprot id: A0A0H4WA50
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1379910:TH63 RS13870
gene id: 1379910:TH63_RS13870
uniprot id: A0A0H4VRA0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1379910:TH63 RS00920
gene id: 1379910:TH63_RS00920
uniprot id: A0A0H4VL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1379910:TH63 RS04510
gene id: 1379910:TH63_RS04510
uniprot id: A0A0H4VMG5
names: Subcellular Location Annotation
messages: Membrane

1379910:TH63 RS00520
gene id: 1379910:TH63_RS00520
uniprot id: A0A0H4W1Z8
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

1379910:TH63 RS07790
gene id: 1379910:TH63_RS07790
uniprot id: A0A0H4VIH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1379910:TH63 RS11510
gene id: 1379910:TH63_RS11510
uniprot id: A0A0H4VUZ2
names: Similarity
messages: Belongs to the SusD family.

1379910:TH63 RS01945
gene id: 1379910:TH63_RS01945
uniprot id: A0A0H4VL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1379910:TH63 RS15425
gene id: 1379910:TH63_RS15425
uniprot id: A0A0H4VN04
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1379910:TH63 RS13140
gene id: 1379910:TH63_RS13140
uniprot id: A0A0H4VQX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1379910:TH63 RS15980
gene id: 1379910:TH63_RS15980
uniprot id: A0A0H4VSN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.