13616:SLC2A4
gene id: 13616:SLC2A4
uniprot id: F7G424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

13616:SUSD1
gene id: 13616:SUSD1
uniprot id: F7FV45
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:OTULINL
gene id: 13616:OTULINL
uniprot id: F6PMI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

13616:T2R62
gene id: 13616:T2R62
uniprot id: Q2AB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:RNASEH2B
gene id: 13616:RNASEH2B
uniprot id: A0A5F8HKH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

13616:TDRD9
gene id: 13616:TDRD9
uniprot id: F6VF39
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

13616:SLC25A43
gene id: 13616:SLC25A43
uniprot id: A0A5F8G6H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:CGA
gene id: 13616:CGA
uniprot id: Q6YNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

13616:NUDT21
gene id: 13616:NUDT21
uniprot id: F7DTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

13616:CLDN16
gene id: 13616:CLDN16
uniprot id: F7F3I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:GOLM1
gene id: 13616:GOLM1
uniprot id: F7ELM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

13616:ESYT3
gene id: 13616:ESYT3
uniprot id: F7FRN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100020587
gene id: 13616:LOC100020587
uniprot id: F7CSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

13616:ATG4B
gene id: 13616:ATG4B
uniprot id: A0A5F8GW90
uniprot id: F6PG58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

13616:SPSB4
gene id: 13616:SPSB4
uniprot id: F7B312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

13616:CHMP2B
gene id: 13616:CHMP2B
uniprot id: F6VMU4
names: Similarity
messages: Belongs to the SNF7 family.

13616:RBBP4
gene id: 13616:RBBP4
uniprot id: F7AJD6
names: Subcellular Location Annotation
messages: Nucleus

13616:monDomV1R1273
gene id: 13616:monDomV1R1273
uniprot id: A0A5F8G2Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMEM45B
gene id: 13616:TMEM45B
uniprot id: F7C2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

13616:TATDN3
gene id: 13616:TATDN3
uniprot id: A0A5F8GEE7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

13616:LOC100020231
gene id: 13616:LOC100020231
uniprot id: F6ZZ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

13616:VN2R591
gene id: 13616:VN2R591
uniprot id: A0A5F8GRN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LNPEP
gene id: 13616:LNPEP
uniprot id: F6SKQ6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:HOXD10
gene id: 13616:HOXD10
uniprot id: F7AWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:HGH1
gene id: 13616:HGH1
uniprot id: F7DQL3
names: Similarity
messages: Belongs to the HGH1 family.

13616:KIF27
gene id: 13616:KIF27
uniprot id: F7FRJ7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:CEMIP2
gene id: 13616:CEMIP2
uniprot id: F7CEF4
names: Similarity
messages: Belongs to the CEMIP family.

13616:TRAPPC3
gene id: 13616:TRAPPC3
uniprot id: A0A5F8GB57
uniprot id: K7E5X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

13616:CTSO
gene id: 13616:CTSO
uniprot id: F6S7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:PGLYRP2
gene id: 13616:PGLYRP2
uniprot id: F6ZE34
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

13616:SEC63
gene id: 13616:SEC63
uniprot id: F7AKK5
names: Subcellular Location Annotation
messages: Membrane

13616:LTB
gene id: 13616:LTB
uniprot id: F6Z4T6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:TPST1
gene id: 13616:TPST1
uniprot id: A0A5F8G635
uniprot id: A0A5F8GXI1
uniprot id: F7CN44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

13616:MANBAL
gene id: 13616:MANBAL
uniprot id: F6WQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

13616:LOC100015032
gene id: 13616:LOC100015032
uniprot id: F6VP59
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:LOC100024321
gene id: 13616:LOC100024321
uniprot id: F6Q2J6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100021085
gene id: 13616:LOC100021085
uniprot id: F6U1C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

13616:LSM2
gene id: 13616:LSM2
uniprot id: F7BWI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

13616:ANKH
gene id: 13616:ANKH
uniprot id: F6Q5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

13616:LOC100013696
gene id: 13616:LOC100013696
uniprot id: F7C1Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MKNK1
gene id: 13616:MKNK1
uniprot id: F6VJP3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100021368
gene id: 13616:LOC100021368
uniprot id: A0A5F8H5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:KIF13A
gene id: 13616:KIF13A
uniprot id: A0A5F8HK25
uniprot id: F6S7Y0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:TXNL4A
gene id: 13616:TXNL4A
uniprot id: A0A5F8H5Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

13616:GADD45B
gene id: 13616:GADD45B
uniprot id: F6U5E4
names: Similarity
messages: Belongs to the GADD45 family.

13616:LOC100020103
gene id: 13616:LOC100020103
uniprot id: A0A5F8HBA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NACC1
gene id: 13616:NACC1
uniprot id: F6U150
names: Subcellular Location Annotation
messages: Nucleus

13616:MCM2
gene id: 13616:MCM2
uniprot id: F6ZG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:DPYSL3
gene id: 13616:DPYSL3
uniprot id: A0A5F8GT34
uniprot id: F6URW8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

13616:ELOVL1
gene id: 13616:ELOVL1
uniprot id: F6WIJ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:DCBLD1
gene id: 13616:DCBLD1
uniprot id: F7CFE9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NDUFA5
gene id: 13616:NDUFA5
uniprot id: A0A5F8H5G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:ADK
gene id: 13616:ADK
uniprot id: A0A5F8GHX5
uniprot id: F6WM42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

13616:GJB2
gene id: 13616:GJB2
uniprot id: F6WYM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:LHFPL5
gene id: 13616:LHFPL5
uniprot id: F6X7Q0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100030139
gene id: 13616:LOC100030139
uniprot id: A0A5F8GHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

13616:GNG3
gene id: 13616:GNG3
uniprot id: F7GI54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:MYO1B
gene id: 13616:MYO1B
uniprot id: A0A5F8G3G8
uniprot id: A0A5F8GY12
uniprot id: A0A5F8HAT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:PTP4A1
gene id: 13616:PTP4A1
uniprot id: F7FQJ1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:LOC100019050
gene id: 13616:LOC100019050
uniprot id: F7FBW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NOTCH4
gene id: 13616:NOTCH4
uniprot id: F6SDD3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

13616:TMEM200B
gene id: 13616:TMEM200B
uniprot id: F7EN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

13616:LOC100020131
gene id: 13616:LOC100020131
uniprot id: F7BCC7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:GFUS
gene id: 13616:GFUS
uniprot id: F6ZAF0
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

13616:ADAM33
gene id: 13616:ADAM33
uniprot id: F6UN04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100032185
gene id: 13616:LOC100032185
uniprot id: F6SNI6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

13616:LSM6
gene id: 13616:LSM6
uniprot id: A0A5F8GCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

13616:RBM5
gene id: 13616:RBM5
uniprot id: F7EJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

13616:PDHX
gene id: 13616:PDHX
uniprot id: F7F2T0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

13616:KIF7
gene id: 13616:KIF7
uniprot id: F6UTW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:SFRP2
gene id: 13616:SFRP2
uniprot id: F7GHD3
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:INPP5K
gene id: 13616:INPP5K
uniprot id: A0A5F8HKR9
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

13616:TNFRSF10B
gene id: 13616:TNFRSF10B
uniprot id: F7EED4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PRPF4
gene id: 13616:PRPF4
uniprot id: F6RSY7
names: Subcellular Location Annotation
messages: Nucleus speckle

13616:LOC100017458
gene id: 13616:LOC100017458
uniprot id: F6ZUA9
names: Subcellular Location Annotation
messages: Membrane

13616:SUDS3
gene id: 13616:SUDS3
uniprot id: F6XZ37
names: Subcellular Location Annotation
messages: Nucleus

13616:PSEN1
gene id: 13616:PSEN1
uniprot id: F6PH04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

13616:POLL
gene id: 13616:POLL
uniprot id: A0A5F8H1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

13616:FGD4
gene id: 13616:FGD4
uniprot id: A0A5F8GPM8
names: Subcellular Location Annotation
messages: cytoskeleton

13616:FAM229A
gene id: 13616:FAM229A
uniprot id: F6ZTY7
names: Similarity
messages: Belongs to the FAM229 family.

13616:TSFM
gene id: 13616:TSFM
uniprot id: A0A5F8GUK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

13616:SHMT1
gene id: 13616:SHMT1
uniprot id: A0A5F8HF15
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

13616:LOC100009985
gene id: 13616:LOC100009985
uniprot id: F6Y2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:XIAP
gene id: 13616:XIAP
uniprot id: F7CGN1
names: Similarity
messages: Belongs to the IAP family.

13616:UBE2D2
gene id: 13616:UBE2D2
uniprot id: A0A5F8HBV9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:RPL32
gene id: 13616:RPL32
uniprot id: A0A5F8HAP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

13616:LOC100020874
gene id: 13616:LOC100020874
uniprot id: F7FSX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

13616:SENP8
gene id: 13616:SENP8
uniprot id: F6W1R5
names: Similarity
messages: Belongs to the peptidase C48 family.

13616:POLR1C
gene id: 13616:POLR1C
uniprot id: F7G057
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

13616:SERPINH1
gene id: 13616:SERPINH1
uniprot id: F6PGJ9
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

13616:SEC61A2
gene id: 13616:SEC61A2
uniprot id: F7FIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:EPC2
gene id: 13616:EPC2
uniprot id: A0A5F8GET6
uniprot id: F7DWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

13616:ATF7IP
gene id: 13616:ATF7IP
uniprot id: F7B6U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

13616:MAPK4
gene id: 13616:MAPK4
uniprot id: F6YVG7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

13616:LOC103098338
gene id: 13616:LOC103098338
uniprot id: F7E383
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:ST7
gene id: 13616:ST7
uniprot id: A0A5F8GIW5
uniprot id: A0A5F8GL78
uniprot id: F7FRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

13616:SPPL2A
gene id: 13616:SPPL2A
uniprot id: A0A5F8H1Y2
uniprot id: F6YF27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

13616:LOC100026593
gene id: 13616:LOC100026593
uniprot id: A0A5F8GKM5
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:ZIC2
gene id: 13616:ZIC2
uniprot id: F6W6Z2
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

13616:BMP8A
gene id: 13616:BMP8A
uniprot id: F6YJC5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:IMMP2L
gene id: 13616:IMMP2L
uniprot id: F7GH07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ALDH18A1
gene id: 13616:ALDH18A1
uniprot id: F7F6P3
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

13616:LOC100012380
gene id: 13616:LOC100012380
uniprot id: F7DNW8
names: Subcellular Location Annotation
messages: Membrane

13616:ALDH1A3
gene id: 13616:ALDH1A3
uniprot id: F7DI08
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:VN2R537
gene id: 13616:VN2R537
uniprot id: F7G4E3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:BOD1
gene id: 13616:BOD1
uniprot id: F6Z5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

13616:UGP2
gene id: 13616:UGP2
uniprot id: A0A5F8HI35
uniprot id: F6PIH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

13616:VEGFC
gene id: 13616:VEGFC
uniprot id: F6ZK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

13616:LOC100016216
gene id: 13616:LOC100016216
uniprot id: F6VIJ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

13616:AATF
gene id: 13616:AATF
uniprot id: F7EGI5
names: Similarity
messages: Belongs to the AATF family.

13616:DUSP26
gene id: 13616:DUSP26
uniprot id: F7EMZ0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:PTPN14
gene id: 13616:PTPN14
uniprot id: F6SJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

13616:LOC103104413
gene id: 13616:LOC103104413
uniprot id: K7E690
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:FGFR1OP2
gene id: 13616:FGFR1OP2
uniprot id: A0A5F8G9V1
uniprot id: F6YNF0
names: Similarity
messages: Belongs to the SIKE family.

13616:PPP4R2
gene id: 13616:PPP4R2
uniprot id: F7G9R3
names: Similarity
messages: Belongs to the PPP4R2 family.

13616:LOC100013147
gene id: 13616:LOC100013147
uniprot id: F7C2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:UCP2
gene id: 13616:UCP2
uniprot id: F6YX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:COPE
gene id: 13616:COPE
uniprot id: F7EVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

13616:ARL1
gene id: 13616:ARL1
uniprot id: F6PNX7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:LIMK2
gene id: 13616:LIMK2
uniprot id: A0A5F8H5F0
uniprot id: F6QSD0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

13616:TATDN2
gene id: 13616:TATDN2
uniprot id: F7BXM4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

13616:GINS1
gene id: 13616:GINS1
uniprot id: F7EGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

13616:CHST13
gene id: 13616:CHST13
uniprot id: F7BKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:T2R41
gene id: 13616:T2R41
uniprot id: Q2AB86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:TCN2
gene id: 13616:TCN2
uniprot id: F6QKL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

13616:LOC100010167
gene id: 13616:LOC100010167
uniprot id: F7DY38
names: Subcellular Location Annotation
messages: Membrane

13616:KCNK9
gene id: 13616:KCNK9
uniprot id: F6SSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

13616:LOC100011919
gene id: 13616:LOC100011919
uniprot id: F6QTN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:DACT1
gene id: 13616:DACT1
uniprot id: F7ELJ9
names: Similarity
messages: Belongs to the dapper family.

13616:LOC100027533
gene id: 13616:LOC100027533
uniprot id: F7AIJ8
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

13616:MMS22L
gene id: 13616:MMS22L
uniprot id: F7F1R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

13616:SMAD1
gene id: 13616:SMAD1
uniprot id: F6TU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:TECPR1
gene id: 13616:TECPR1
uniprot id: F7F2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

13616:DOK4
gene id: 13616:DOK4
uniprot id: F7C3J4
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

13616:MRPL58
gene id: 13616:MRPL58
uniprot id: A0A5F8H4P4
names: Subcellular Location Annotation
messages: Mitochondrion

13616:NUP107
gene id: 13616:NUP107
uniprot id: F7FQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

13616:TFR2
gene id: 13616:TFR2
uniprot id: F6R440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

13616:DOLPP1
gene id: 13616:DOLPP1
uniprot id: A0A5F8GI55
uniprot id: F7FFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

13616:CAND1
gene id: 13616:CAND1
uniprot id: F7GD42
names: Similarity
messages: Belongs to the CAND family.

13616:TRAF5
gene id: 13616:TRAF5
uniprot id: F6Z7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

13616:BTF3
gene id: 13616:BTF3
uniprot id: A0A5F8HF00
names: Similarity
messages: Belongs to the NAC-beta family.

13616:PRRX2
gene id: 13616:PRRX2
uniprot id: F7BTR9
names: Subcellular Location Annotation
messages: Nucleus

13616:IL13RA1
gene id: 13616:IL13RA1
uniprot id: F6QXZ5
names: Subcellular Location Annotation
messages: Membrane

13616:SPATA31F1
gene id: 13616:SPATA31F1
uniprot id: A0A5F8GKW9
names: Similarity
messages: Belongs to the SPATA31 family.

13616:MAP6
gene id: 13616:MAP6
uniprot id: A0A5F8GDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

13616:RAD52
gene id: 13616:RAD52
uniprot id: F6Q9I8
names: Similarity
messages: Belongs to the RAD52 family.

13616:TMEM63C
gene id: 13616:TMEM63C
uniprot id: A0A5F8GYG1
uniprot id: A0A5F8HGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

13616:LOC100617599
gene id: 13616:LOC100617599
uniprot id: F7BWD5
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:DNAAF2
gene id: 13616:DNAAF2
uniprot id: F6S6H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

13616:LOC100025112
gene id: 13616:LOC100025112
uniprot id: A0A5F8G2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP2R2C
gene id: 13616:PPP2R2C
uniprot id: A0A5F8H9I6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

13616:SMIM15
gene id: 13616:SMIM15
uniprot id: A0A5F8GRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

13616:LOC100020689
gene id: 13616:LOC100020689
uniprot id: F6S985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SIX3
gene id: 13616:SIX3
uniprot id: A0A5F8GZX1
names: Subcellular Location Annotation
messages: Nucleus

13616:UMOD
gene id: 13616:UMOD
uniprot id: F7CX48
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

13616:LOC100616680
gene id: 13616:LOC100616680
uniprot id: F7C289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CDK5R2
gene id: 13616:CDK5R2
uniprot id: A0A5F8H8P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

13616:SH3BP5L
gene id: 13616:SH3BP5L
uniprot id: F7B0V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

13616:FAM174B
gene id: 13616:FAM174B
uniprot id: F6ZLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

13616:NELL1
gene id: 13616:NELL1
uniprot id: F7EDR3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RAB27A
gene id: 13616:RAB27A
uniprot id: F7D6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

13616:NR2C2
gene id: 13616:NR2C2
uniprot id: F6UFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:XK
gene id: 13616:XK
uniprot id: F6U2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:SNAP23
gene id: 13616:SNAP23
uniprot id: F7FGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

13616:SBK2
gene id: 13616:SBK2
uniprot id: H9H734
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100020928
gene id: 13616:LOC100020928
uniprot id: K7E218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:KRAS
gene id: 13616:KRAS
uniprot id: Q07983
names: Activity Regulation
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with SOS1 (By similarity). Interacts (when farnesylated) with GPR31 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: Mutation which changes position 61 is implicated in ultraviolet radiation-induced (UVR-induced) eye tumor.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:8312604). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
messages: cytosol

13616:MRPL51
gene id: 13616:MRPL51
uniprot id: F7G4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

13616:RPS7
gene id: 13616:RPS7
uniprot id: F7FKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

13616:SDC2
gene id: 13616:SDC2
uniprot id: F6PWB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

13616:INTS9
gene id: 13616:INTS9
uniprot id: A0A5F8HFE7
uniprot id: F6PRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

13616:DBX2
gene id: 13616:DBX2
uniprot id: F7GL38
names: Subcellular Location Annotation
messages: Nucleus

13616:SEC62
gene id: 13616:SEC62
uniprot id: F7CA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SAMM50
gene id: 13616:SAMM50
uniprot id: F6ZTF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

13616:CSTF2
gene id: 13616:CSTF2
uniprot id: F6QNJ2
names: Subcellular Location Annotation
messages: Nucleus

13616:SEC22A
gene id: 13616:SEC22A
uniprot id: F6PSR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

13616:HOXD11
gene id: 13616:HOXD11
uniprot id: F7BJ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:ABR
gene id: 13616:ABR
uniprot id: A0A5F8GDH1
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

13616:CDK5RAP1
gene id: 13616:CDK5RAP1
uniprot id: F6TGF1
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

13616:COPS7A
gene id: 13616:COPS7A
uniprot id: F7FFA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

13616:MAPK13
gene id: 13616:MAPK13
uniprot id: F6TXC2
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

13616:TPH1
gene id: 13616:TPH1
uniprot id: F7DGX6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

13616:INIP
gene id: 13616:INIP
uniprot id: F6U5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

13616:TUBGCP6
gene id: 13616:TUBGCP6
uniprot id: F7FUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: centrosome

13616:ZC3H12D
gene id: 13616:ZC3H12D
uniprot id: A0A5F8H4G0
names: Similarity
messages: Belongs to the ZC3H12 family.

13616:LOC100022736
gene id: 13616:LOC100022736
uniprot id: F7CAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103101763
gene id: 13616:LOC103101763
uniprot id: F6UMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:ASIP
gene id: 13616:ASIP
uniprot id: F6YH41
names: Subcellular Location Annotation
messages: Secreted

13616:UBL3
gene id: 13616:UBL3
uniprot id: A0A5F8GM48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CENPL
gene id: 13616:CENPL
uniprot id: F6RA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

13616:PIWIL4
gene id: 13616:PIWIL4
uniprot id: F6SZK3
names: Similarity
messages: Belongs to the argonaute family.

13616:LOC100031215
gene id: 13616:LOC100031215
uniprot id: A0A5F8GM87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC25A15
gene id: 13616:SLC25A15
uniprot id: A0A5F8H400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:FAT3
gene id: 13616:FAT3
uniprot id: A0A5F8HHQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TAF7L
gene id: 13616:TAF7L
uniprot id: F7GDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

13616:CHRNA3
gene id: 13616:CHRNA3
uniprot id: F7G2L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:PPP3CC
gene id: 13616:PPP3CC
uniprot id: F7BLB6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

13616:OSGEP
gene id: 13616:OSGEP
uniprot id: F6RZ40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

13616:LOC103102267
gene id: 13616:LOC103102267
uniprot id: F6PT66
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:HSF2
gene id: 13616:HSF2
uniprot id: A0A5F8HDN1
uniprot id: F7E523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:LOC103093665
gene id: 13616:LOC103093665
uniprot id: F7BK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:RBBP7
gene id: 13616:RBBP7
uniprot id: F6QE05
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100011560
gene id: 13616:LOC100011560
uniprot id: A0A5F8GDX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:NSUN4
gene id: 13616:NSUN4
uniprot id: F6RHT5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

13616:GH1
gene id: 13616:GH1
uniprot id: Q9GL60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).
messages: Secreted

13616:CDK8
gene id: 13616:CDK8
uniprot id: F6TLP1
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CASP18
gene id: 13616:CASP18
uniprot id: A9YDV7
uniprot id: K7E316
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:MRPL40
gene id: 13616:MRPL40
uniprot id: F6XNB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

13616:TAFA2
gene id: 13616:TAFA2
uniprot id: F6X1T2
names: Similarity
messages: Belongs to the TAFA family.

13616:NGB
gene id: 13616:NGB
uniprot id: Q3KN63
names: Similarity
messages: Belongs to the globin family.

13616:EDC4
gene id: 13616:EDC4
uniprot id: F7G5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

13616:MBTPS2
gene id: 13616:MBTPS2
uniprot id: F7GI63
names: Similarity
messages: Belongs to the peptidase M50A family.

13616:CXXC5
gene id: 13616:CXXC5
uniprot id: F7CW03
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SFT2D1
gene id: 13616:SFT2D1
uniprot id: F6TJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:SEPTIN9
gene id: 13616:SEPTIN9
uniprot id: F6T758
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

13616:PDPR
gene id: 13616:PDPR
uniprot id: F6ZEM0
names: Similarity
messages: Belongs to the GcvT family.

13616:IRX3
gene id: 13616:IRX3
uniprot id: F7FAB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:HEXD
gene id: 13616:HEXD
uniprot id: F6SI50
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

13616:MCPH1
gene id: 13616:MCPH1
uniprot id: A0A5F8HGF8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

13616:SPCS3
gene id: 13616:SPCS3
uniprot id: A0A5F8GFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:ATP6V1G1
gene id: 13616:ATP6V1G1
uniprot id: F6QN45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:LOC100025494
gene id: 13616:LOC100025494
uniprot id: A0A5F8GDN9
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.

13616:VN2R635
gene id: 13616:VN2R635
uniprot id: A0A5F8HIB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:C6
gene id: 13616:C6
uniprot id: F7BFY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:PRSS16
gene id: 13616:PRSS16
uniprot id: F6PG02
names: Similarity
messages: Belongs to the peptidase S28 family.

13616:ANAPC11
gene id: 13616:ANAPC11
uniprot id: A0A5F8H6S1
names: Similarity
messages: Belongs to the RING-box family.

13616:TMEM199
gene id: 13616:TMEM199
uniprot id: F6QU23
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CLRN2
gene id: 13616:CLRN2
uniprot id: F7AVP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:TACR3
gene id: 13616:TACR3
uniprot id: F7E6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100617279
gene id: 13616:LOC100617279
uniprot id: F7D6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DTNA
gene id: 13616:DTNA
uniprot id: A0A5F8GEV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

13616:EDN3
gene id: 13616:EDN3
uniprot id: F6ZC95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

13616:VGLL2
gene id: 13616:VGLL2
uniprot id: A0A5F8GL17
uniprot id: F6ZY15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

13616:STK11IP
gene id: 13616:STK11IP
uniprot id: F7FHM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

13616:VXN
gene id: 13616:VXN
uniprot id: F6UTN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

13616:NDUFB4
gene id: 13616:NDUFB4
uniprot id: A0A5F8GMT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:AQP7
gene id: 13616:AQP7
uniprot id: F7E6D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:EYA3
gene id: 13616:EYA3
uniprot id: A0A5F8HET8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

13616:AKIRIN1
gene id: 13616:AKIRIN1
uniprot id: F6Y5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

13616:LOC100019316
gene id: 13616:LOC100019316
uniprot id: A0A5F8GJ95
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:PEX10
gene id: 13616:PEX10
uniprot id: F7ELT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

13616:CDCA8
gene id: 13616:CDCA8
uniprot id: F7E4K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

13616:UBE2B
gene id: 13616:UBE2B
uniprot id: F6TQE0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:RAB3GAP2
gene id: 13616:RAB3GAP2
uniprot id: F6V9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

13616:NDRG1
gene id: 13616:NDRG1
uniprot id: F7DPF6
names: Similarity
messages: Belongs to the NDRG family.

13616:HEATR1
gene id: 13616:HEATR1
uniprot id: F7G8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

13616:PHAF1
gene id: 13616:PHAF1
uniprot id: F7AGW7
names: Similarity
messages: Belongs to the PHAF1 family.

13616:CASP16
gene id: 13616:CASP16
uniprot id: F7BTN7
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:GABPA
gene id: 13616:GABPA
uniprot id: F6QZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:SLC5A11
gene id: 13616:SLC5A11
uniprot id: F7AU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:GBX2
gene id: 13616:GBX2
uniprot id: F7GJL0
names: Subcellular Location Annotation
messages: Nucleus

13616:TPRG1
gene id: 13616:TPRG1
uniprot id: F7FUV1
names: Similarity
messages: Belongs to the TPRG1 family.

13616:FABP5
gene id: 13616:FABP5
uniprot id: F7BV76
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:DNASE2
gene id: 13616:DNASE2
uniprot id: F6VJD5
names: Similarity
messages: Belongs to the DNase II family.

13616:CHMP6
gene id: 13616:CHMP6
uniprot id: A0A5F8GJB8
names: Similarity
messages: Belongs to the SNF7 family.

13616:ATP5F1A
gene id: 13616:ATP5F1A
uniprot id: F6THT5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

13616:UNC5C
gene id: 13616:UNC5C
uniprot id: F6Q8P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

13616:PI4KB
gene id: 13616:PI4KB
uniprot id: A0A5F8H4E4
uniprot id: F7DVF5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:USP49
gene id: 13616:USP49
uniprot id: F7DCJ7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:TAFA4
gene id: 13616:TAFA4
uniprot id: K7DZQ7
names: Similarity
messages: Belongs to the TAFA family.

13616:RLN3
gene id: 13616:RLN3
uniprot id: A0A5F8GDK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

13616:TMEM230
gene id: 13616:TMEM230
uniprot id: F6YEP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

13616:TBCE
gene id: 13616:TBCE
uniprot id: A0A5F8GJR5
uniprot id: F7FGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

13616:CCNA1
gene id: 13616:CCNA1
uniprot id: F6USE6
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

13616:ART5
gene id: 13616:ART5
uniprot id: F7A3I9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:LOC100013044
gene id: 13616:LOC100013044
uniprot id: F6SDJ3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

13616:PYCR1
gene id: 13616:PYCR1
uniprot id: A0A5F8G2X3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:SERPINB5
gene id: 13616:SERPINB5
uniprot id: F7DMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

13616:OIT3
gene id: 13616:OIT3
uniprot id: F6YCC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ST8SIA6
gene id: 13616:ST8SIA6
uniprot id: F6XAK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:TMEM135
gene id: 13616:TMEM135
uniprot id: F6VVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

13616:DYNC2LI1
gene id: 13616:DYNC2LI1
uniprot id: F6XMM1
uniprot id: F7EEI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Belongs to the dynein light intermediate chain family.
messages: Membrane
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

13616:LOC100026824
gene id: 13616:LOC100026824
uniprot id: A0A5F8HDW6
uniprot id: F6QBU5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:CACNB1
gene id: 13616:CACNB1
uniprot id: A0A5F8G4K2
uniprot id: F6VFL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

13616:CHRM1
gene id: 13616:CHRM1
uniprot id: F7EL12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

13616:LOC100011334
gene id: 13616:LOC100011334
uniprot id: A0A5F8HHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

13616:AMZ1
gene id: 13616:AMZ1
uniprot id: F6TG05
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

13616:SLC2A6
gene id: 13616:SLC2A6
uniprot id: F7CS72
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:monDomV1R1212
gene id: 13616:monDomV1R1212
uniprot id: A0A5F8G9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ETFA
gene id: 13616:ETFA
uniprot id: F7CUV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

13616:MCHR1
gene id: 13616:MCHR1
uniprot id: A0A5F8HBM5
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

13616:ACAD11
gene id: 13616:ACAD11
uniprot id: F7G3S4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:LOC100030366
gene id: 13616:LOC100030366
uniprot id: A0A5F8H0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SEMA5A
gene id: 13616:SEMA5A
uniprot id: F6U008
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:POLR3F
gene id: 13616:POLR3F
uniprot id: F7CFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

13616:KRT16
gene id: 13616:KRT16
uniprot id: A0A5F8GBN6
names: Similarity
messages: Belongs to the intermediate filament family.

13616:AGL
gene id: 13616:AGL
uniprot id: F7GJD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

13616:MAN2A2
gene id: 13616:MAN2A2
uniprot id: F6RWB3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:ZGPAT
gene id: 13616:ZGPAT
uniprot id: F6QEZ5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

13616:INSL3
gene id: 13616:INSL3
uniprot id: A0A5F8HAP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

13616:CKMT2
gene id: 13616:CKMT2
uniprot id: A0A5F8H9F7
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

13616:GRIA1
gene id: 13616:GRIA1
uniprot id: F7B4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:SSR3
gene id: 13616:SSR3
uniprot id: F7AHP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

13616:XYLT1
gene id: 13616:XYLT1
uniprot id: F6XD49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

13616:LOC100011059
gene id: 13616:LOC100011059
uniprot id: F6W5H0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:RGS3
gene id: 13616:RGS3
uniprot id: F6X2A9
names: Subcellular Location Annotation
messages: Cytoplasm

13616:monDomV1R1209
gene id: 13616:monDomV1R1209
uniprot id: A0A5F8HJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TPM1
gene id: 13616:TPM1
uniprot id: A0A5F8H5I4
uniprot id: A0A5F8HBI3
uniprot id: A0A5F8HLP0
uniprot id: F7GGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

13616:ZUP1
gene id: 13616:ZUP1
uniprot id: A0A5F8G7K3
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

13616:PODXL2
gene id: 13616:PODXL2
uniprot id: F6YSG1
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100028279
gene id: 13616:LOC100028279
uniprot id: A0A5F8GE81
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

13616:RPS11
gene id: 13616:RPS11
uniprot id: F7GIM6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

13616:LTK
gene id: 13616:LTK
uniprot id: F6YBY8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

13616:PRPS1
gene id: 13616:PRPS1
uniprot id: H9H6N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

13616:GRIN3A
gene id: 13616:GRIN3A
uniprot id: F7AUG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:PTP4A3
gene id: 13616:PTP4A3
uniprot id: F6SUC7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:FARSB
gene id: 13616:FARSB
uniprot id: F6XVT6
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

13616:LOC100021467
gene id: 13616:LOC100021467
uniprot id: F7GHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:CTLA4
gene id: 13616:CTLA4
uniprot id: A0A5F8GRC7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

13616:CCNE2
gene id: 13616:CCNE2
uniprot id: F6UFV2
names: Similarity
messages: Belongs to the cyclin family.

13616:ARSI
gene id: 13616:ARSI
uniprot id: F6RZZ5
names: Similarity
messages: Belongs to the sulfatase family.

13616:HSDL1
gene id: 13616:HSDL1
uniprot id: F7A6J2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:KCNB1
gene id: 13616:KCNB1
uniprot id: F7AU20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

13616:SLC30A4
gene id: 13616:SLC30A4
uniprot id: F6ZSD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

13616:LOC103097074
gene id: 13616:LOC103097074
uniprot id: K7E2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

13616:PLPPR5
gene id: 13616:PLPPR5
uniprot id: F7FYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:LOC100030208
gene id: 13616:LOC100030208
uniprot id: A0A5F8H4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RER1
gene id: 13616:RER1
uniprot id: F7G5H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

13616:NDUFB1
gene id: 13616:NDUFB1
uniprot id: A0A5F8GL68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:KAT5
gene id: 13616:KAT5
uniprot id: F7AWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

13616:LOC100010714
gene id: 13616:LOC100010714
uniprot id: F7B277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CASQ1
gene id: 13616:CASQ1
uniprot id: F6QTC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

13616:LOC100026938
gene id: 13616:LOC100026938
uniprot id: A0A5F8G1S9
names: Subcellular Location Annotation
messages: Membrane

13616:MODO-UM
gene id: 13616:MODO-UM
uniprot id: C6ZIV8
names: Similarity
messages: Belongs to the MHC class I family.

13616:LOC100020573
gene id: 13616:LOC100020573
uniprot id: F7E8Y9
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:RNF7
gene id: 13616:RNF7
uniprot id: F6QK30
names: Similarity
messages: Belongs to the RING-box family.

13616:HMGN3
gene id: 13616:HMGN3
uniprot id: F6XTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:COPS5
gene id: 13616:COPS5
uniprot id: F7ETC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

13616:NAV2
gene id: 13616:NAV2
uniprot id: A0A5F8G455
uniprot id: A0A5F8GKU8
uniprot id: A0A5F8GNI9
uniprot id: F6ZVI0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

13616:LOC100022115
gene id: 13616:LOC100022115
uniprot id: F6R532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

13616:SEC61A1
gene id: 13616:SEC61A1
uniprot id: F7D5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:TEKT4
gene id: 13616:TEKT4
uniprot id: F6VNC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:GGPS1
gene id: 13616:GGPS1
uniprot id: A0A5F8H0Y3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

13616:PAPSS2
gene id: 13616:PAPSS2
uniprot id: A0A5F8G3N5
uniprot id: F6WHV8
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

13616:LOC100018857
gene id: 13616:LOC100018857
uniprot id: A0A5F8HKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ING1
gene id: 13616:ING1
uniprot id: A0A5F8H4R4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:FEZ1
gene id: 13616:FEZ1
uniprot id: A0A5F8GRW3
names: Similarity
messages: Belongs to the zygin family.

13616:SLC31A2
gene id: 13616:SLC31A2
uniprot id: A0A5F8H6I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:HHIP
gene id: 13616:HHIP
uniprot id: A0A5F8G8G3
uniprot id: F6UT79
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CFAP97
gene id: 13616:CFAP97
uniprot id: A0A5F8GEJ1
uniprot id: A0A5F8HC82
names: Similarity
messages: Belongs to the CFAP97 family.

13616:monDomV1R1253
gene id: 13616:monDomV1R1253
uniprot id: A0A5F8HKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GPAM
gene id: 13616:GPAM
uniprot id: F6S9J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

13616:B3GAT3
gene id: 13616:B3GAT3
uniprot id: F6ZIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100027041
gene id: 13616:LOC100027041
uniprot id: F7AWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

13616:MICOS10
gene id: 13616:MICOS10
uniprot id: F7FLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

13616:PYGB
gene id: 13616:PYGB
uniprot id: F7EZJ9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

13616:LOC100024252
gene id: 13616:LOC100024252
uniprot id: F7EI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TIMP4
gene id: 13616:TIMP4
uniprot id: A0A5F8HLB3
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

13616:RPL8
gene id: 13616:RPL8
uniprot id: F6TDX6
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

13616:ADGRE3
gene id: 13616:ADGRE3
uniprot id: F7GDK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:IGF2R
gene id: 13616:IGF2R
uniprot id: A0A5F8GGA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ABCA3
gene id: 13616:ABCA3
uniprot id: F6PJ24
names: Subcellular Location Annotation
messages: Membrane

13616:EDA
gene id: 13616:EDA
uniprot id: F6UN90
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:TMED7
gene id: 13616:TMED7
uniprot id: A0A5F8GFZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

13616:B9D1
gene id: 13616:B9D1
uniprot id: K7E5P2
names: Subcellular Location Annotation
messages: cilium basal body

13616:FCF1
gene id: 13616:FCF1
uniprot id: F7B4X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

13616:RPS17
gene id: 13616:RPS17
uniprot id: F6QXP9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

13616:PYCR3
gene id: 13616:PYCR3
uniprot id: F6SQV0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:MRPL28
gene id: 13616:MRPL28
uniprot id: F7E6R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

13616:UTP25
gene id: 13616:UTP25
uniprot id: A0A5F8G791
uniprot id: F7GFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

13616:BMP6
gene id: 13616:BMP6
uniprot id: F6UAT4
names: Similarity
messages: Belongs to the TGF-beta family.

13616:C3H5orf22
gene id: 13616:C3H5orf22
uniprot id: F6UM79
names: Similarity
messages: Belongs to the UPF0489 family.

13616:TFDP1
gene id: 13616:TFDP1
uniprot id: F7ED92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:PFN2
gene id: 13616:PFN2
uniprot id: F6T2V7
uniprot id: F6T2W1
names: Similarity
messages: Belongs to the profilin family.

13616:DLC1
gene id: 13616:DLC1
uniprot id: F7FZ87
uniprot id: F7FZ90
names: Subcellular Location Annotation
messages: Cytoplasm

13616:MAP3K9
gene id: 13616:MAP3K9
uniprot id: A0A5F8G873
uniprot id: F6RYB4
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

13616:DUS3L
gene id: 13616:DUS3L
uniprot id: F7FWB8
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

13616:PFN1
gene id: 13616:PFN1
uniprot id: F7DMM7
names: Similarity
messages: Belongs to the profilin family.

13616:TM6SF2
gene id: 13616:TM6SF2
uniprot id: F6WPM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

13616:SULT4A1
gene id: 13616:SULT4A1
uniprot id: F7FS04
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:LOC100031528
gene id: 13616:LOC100031528
uniprot id: F7C2Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TMSB10
gene id: 13616:TMSB10
uniprot id: A0A5F8GWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:LOC100012829
gene id: 13616:LOC100012829
uniprot id: F6QLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ZRANB2
gene id: 13616:ZRANB2
uniprot id: F6Y669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

13616:FICD
gene id: 13616:FICD
uniprot id: A0A5F8HEJ7
names: Similarity
messages: Belongs to the fic family.

13616:TIMM21
gene id: 13616:TIMM21
uniprot id: A0A5F8GY61
uniprot id: A0A5F8HAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

13616:AJAP1
gene id: 13616:AJAP1
uniprot id: F7EYW1
uniprot id: K7E2T9
names: Subcellular Location Annotation
messages: Membrane

13616:RAB9B
gene id: 13616:RAB9B
uniprot id: F6QXW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

13616:PKNOX1
gene id: 13616:PKNOX1
uniprot id: A0A5F8GKA7
uniprot id: F6QYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:NAPG
gene id: 13616:NAPG
uniprot id: F7CB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

13616:SFN
gene id: 13616:SFN
uniprot id: F7FY05
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:PDK4
gene id: 13616:PDK4
uniprot id: H9H6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

13616:CHEK1
gene id: 13616:CHEK1
uniprot id: A0A5F8HJI8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

13616:BPNT2
gene id: 13616:BPNT2
uniprot id: F7G2D4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:OXTR
gene id: 13616:OXTR
uniprot id: F6U716
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

13616:CSAD
gene id: 13616:CSAD
uniprot id: F7G221
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:CSTPP1
gene id: 13616:CSTPP1
uniprot id: A0A5F8GII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

13616:CA11
gene id: 13616:CA11
uniprot id: H9H6N7
uniprot id: K7E3A6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

13616:DENND5A
gene id: 13616:DENND5A
uniprot id: A0A5F8G9V0
uniprot id: F7A8J4
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:AXIN2
gene id: 13616:AXIN2
uniprot id: F6TVK6
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SPHKAP
gene id: 13616:SPHKAP
uniprot id: A0A5F8GXF6
uniprot id: F6UG18
names: Similarity
messages: Belongs to the AKAP110 family.

13616:BORCS5
gene id: 13616:BORCS5
uniprot id: A0A5F8H5A0
uniprot id: F6PG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

13616:GRK1
gene id: 13616:GRK1
uniprot id: F7FA38
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

13616:LOC100018527
gene id: 13616:LOC100018527
uniprot id: F7F8X9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

13616:ESCO1
gene id: 13616:ESCO1
uniprot id: F7G2W9
names: Subcellular Location Annotation
messages: Nucleus

13616:JRKL
gene id: 13616:JRKL
uniprot id: F7GFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

13616:GRN
gene id: 13616:GRN
uniprot id: F6QWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

13616:CLPTM1
gene id: 13616:CLPTM1
uniprot id: A0A5F8GPD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

13616:B3GLCT
gene id: 13616:B3GLCT
uniprot id: F7G0B6
names: Subcellular Location Annotation
messages: Membrane

13616:PPP1R15B
gene id: 13616:PPP1R15B
uniprot id: F7BX77
names: Similarity
messages: Belongs to the PPP1R15 family.

13616:SLC25A47
gene id: 13616:SLC25A47
uniprot id: F7AZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:AARS2
gene id: 13616:AARS2
uniprot id: A0A5F8H2U3
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

13616:VN2R594
gene id: 13616:VN2R594
uniprot id: F7BS98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CHRM2
gene id: 13616:CHRM2
uniprot id: F7DJJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

13616:GALK2
gene id: 13616:GALK2
uniprot id: F7EGU0
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

13616:DDX1
gene id: 13616:DDX1
uniprot id: F6VNU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

13616:CAST
gene id: 13616:CAST
uniprot id: A0A5F8H065
uniprot id: F7GIJ5
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

13616:VN2R501
gene id: 13616:VN2R501
uniprot id: A0A5F8GMF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ADAM15
gene id: 13616:ADAM15
uniprot id: A0A5F8GNU1
uniprot id: A0A5F8HBV1
uniprot id: F6U405
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NDUFA11
gene id: 13616:NDUFA11
uniprot id: F7FWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

13616:CYLD
gene id: 13616:CYLD
uniprot id: F7BMW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

13616:LOC100619985
gene id: 13616:LOC100619985
uniprot id: F6Z5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100019409
gene id: 13616:LOC100019409
uniprot id: F6UPJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CZIB
gene id: 13616:CZIB
uniprot id: F6URI1
names: Similarity
messages: Belongs to the UPF0587 family.

13616:PIH1D1
gene id: 13616:PIH1D1
uniprot id: F6QPU7
names: Similarity
messages: Belongs to the PIH1 family.

13616:GADL1
gene id: 13616:GADL1
uniprot id: F7CF79
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:LOC100018300
gene id: 13616:LOC100018300
uniprot id: F6SJG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion inner membrane

13616:LIN9
gene id: 13616:LIN9
uniprot id: F6ZUZ8
names: Similarity
messages: Belongs to the lin-9 family.

13616:ELOVL4
gene id: 13616:ELOVL4
uniprot id: A0A5F8GPP4
uniprot id: F6XUV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:SLC25A34
gene id: 13616:SLC25A34
uniprot id: F7DWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:NTN3
gene id: 13616:NTN3
uniprot id: F6SLT4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VN2R640
gene id: 13616:VN2R640
uniprot id: A0A5F8GXZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:UCN
gene id: 13616:UCN
uniprot id: F7AVH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

13616:CUL3
gene id: 13616:CUL3
uniprot id: F6UH62
names: Similarity
messages: Belongs to the cullin family.

13616:CCDC126
gene id: 13616:CCDC126
uniprot id: A0A5F8H3D2
names: Subcellular Location Annotation
messages: Secreted

13616:PPIL6
gene id: 13616:PPIL6
uniprot id: A0A5F8G7X9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:LOC100023660
gene id: 13616:LOC100023660
uniprot id: A0A5F8GPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

13616:PPT2
gene id: 13616:PPT2
uniprot id: A0A5F8GWX6
uniprot id: F7G659
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

13616:STRN
gene id: 13616:STRN
uniprot id: A0A5F8H540
uniprot id: F6WH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

13616:FUS
gene id: 13616:FUS
uniprot id: F6WGL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

13616:FAR1
gene id: 13616:FAR1
uniprot id: F6XVM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

13616:LOC100021555
gene id: 13616:LOC100021555
uniprot id: F6V553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

13616:TMEM200C
gene id: 13616:TMEM200C
uniprot id: F7EYB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

13616:SPOCK2
gene id: 13616:SPOCK2
uniprot id: F6YTC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:monDomV1R1292
gene id: 13616:monDomV1R1292
uniprot id: H9H658
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PTX3
gene id: 13616:PTX3
uniprot id: A0A5F8H1C1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100015831
gene id: 13616:LOC100015831
uniprot id: A0A5F8HAI6
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:HOXA7
gene id: 13616:HOXA7
uniprot id: A0A5F8GL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:VGLL1
gene id: 13616:VGLL1
uniprot id: F6R4K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

13616:SLC11A2
gene id: 13616:SLC11A2
uniprot id: F7EQK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

13616:CYP1A1
gene id: 13616:CYP1A1
uniprot id: F7DFG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:CEMIP
gene id: 13616:CEMIP
uniprot id: F6SZF3
names: Similarity
messages: Belongs to the CEMIP family.

13616:THBS2
gene id: 13616:THBS2
uniprot id: F6XY15
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NMT2
gene id: 13616:NMT2
uniprot id: F6XMS8
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

13616:TMEM14C
gene id: 13616:TMEM14C
uniprot id: F6XWW6
names: Similarity
messages: Belongs to the TMEM14 family.

13616:SLCO2A1
gene id: 13616:SLCO2A1
uniprot id: F7BQX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:TANGO6
gene id: 13616:TANGO6
uniprot id: A0A5F8GJE4
names: Similarity
messages: Belongs to the Tango6 family.

13616:CUBN
gene id: 13616:CUBN
uniprot id: F6UUU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100618848
gene id: 13616:LOC100618848
uniprot id: F7AKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TBL1XR1
gene id: 13616:TBL1XR1
uniprot id: F7G392
names: Similarity
messages: Belongs to the WD repeat EBI family.

13616:MAP3K10
gene id: 13616:MAP3K10
uniprot id: F7CPB8
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

13616:PDCL2
gene id: 13616:PDCL2
uniprot id: F7DL69
names: Similarity
messages: Belongs to the phosducin family.

13616:SLC2A1
gene id: 13616:SLC2A1
uniprot id: F6TLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Photoreceptor inner segment

13616:VN2R570
gene id: 13616:VN2R570
uniprot id: A0A5F8GA41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PLP1
gene id: 13616:PLP1
uniprot id: K7E0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

13616:ARPC5L
gene id: 13616:ARPC5L
uniprot id: F6WN64
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

13616:XIRP2
gene id: 13616:XIRP2
uniprot id: A0A5F8GTW9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

13616:LOC100022062
gene id: 13616:LOC100022062
uniprot id: A0A5F8G5S9
names: Similarity
messages: Belongs to the SPT2 family.

13616:HAPLN4
gene id: 13616:HAPLN4
uniprot id: F6UF93
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:HMGB2
gene id: 13616:HMGB2
uniprot id: A0A5F8GGH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

13616:LOC100015236
gene id: 13616:LOC100015236
uniprot id: F6TXZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

13616:EVL
gene id: 13616:EVL
uniprot id: A0A5F8H137
uniprot id: A0A5F8H882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

13616:B3GNT4
gene id: 13616:B3GNT4
uniprot id: F7CXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:CDC123
gene id: 13616:CDC123
uniprot id: A0A5F8GMB0
uniprot id: F6R2R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

13616:COG2
gene id: 13616:COG2
uniprot id: A0A5F8GVG9
names: Similarity
messages: Belongs to the COG2 family.

13616:LOC100030370
gene id: 13616:LOC100030370
uniprot id: F6W6I4
names: Similarity
messages: Belongs to the AccD/PCCB family.

13616:DNM1L
gene id: 13616:DNM1L
uniprot id: A0A5F8HCP4
uniprot id: F6WIN1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

13616:PALS1
gene id: 13616:PALS1
uniprot id: F6VCY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

13616:TDP1
gene id: 13616:TDP1
uniprot id: F6PJT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

13616:RHO
gene id: 13616:RHO
uniprot id: F7F2J1
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

13616:RARS2
gene id: 13616:RARS2
uniprot id: F6PVI2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:GPR37
gene id: 13616:GPR37
uniprot id: F6XYC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:DACT2
gene id: 13616:DACT2
uniprot id: F6TV63
names: Similarity
messages: Belongs to the dapper family.

13616:LOC100030124
gene id: 13616:LOC100030124
uniprot id: A0A5F8GVV4
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

13616:COPB1
gene id: 13616:COPB1
uniprot id: F7EEU7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:PCSK6
gene id: 13616:PCSK6
uniprot id: F7B8Z0
names: Similarity
messages: Belongs to the peptidase S8 family.

13616:SLC25A51
gene id: 13616:SLC25A51
uniprot id: F7BG29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:DPH2
gene id: 13616:DPH2
uniprot id: F6Q4T5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

13616:CWC25
gene id: 13616:CWC25
uniprot id: F6WUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

13616:EFNA1
gene id: 13616:EFNA1
uniprot id: F6UJM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ROGDI
gene id: 13616:ROGDI
uniprot id: F7AI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Presynapse
messages: Vesicle
messages: synaptic vesicle

13616:LTBP2
gene id: 13616:LTBP2
uniprot id: F7FRW6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:RHPN2
gene id: 13616:RHPN2
uniprot id: F6Z6B8
names: Similarity
messages: Belongs to the RHPN family.

13616:IL10RB
gene id: 13616:IL10RB
uniprot id: F6V1X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

13616:CLCN6
gene id: 13616:CLCN6
uniprot id: F7BC48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100021064
gene id: 13616:LOC100021064
uniprot id: F7CGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:LOC100032592
gene id: 13616:LOC100032592
uniprot id: F7G5F8
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:NANOS1
gene id: 13616:NANOS1
uniprot id: F7GJT4
names: Similarity
messages: Belongs to the nanos family.

13616:RAMAC
gene id: 13616:RAMAC
uniprot id: F6WSP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

13616:monDomV1R1256
gene id: 13616:monDomV1R1256
uniprot id: A0A5F8GZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MSTN
gene id: 13616:MSTN
uniprot id: F6QWE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

13616:DDAH1
gene id: 13616:DDAH1
uniprot id: A0A5F8G8Q3
uniprot id: A0A5F8H3U8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

13616:GPRC6A
gene id: 13616:GPRC6A
uniprot id: F6ZXM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RAP1GDS1
gene id: 13616:RAP1GDS1
uniprot id: A0A5F8G5W2
uniprot id: F7BAB1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

13616:FRK
gene id: 13616:FRK
uniprot id: F6Z7T8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:PTPRK
gene id: 13616:PTPRK
uniprot id: F6YJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

13616:LOC100027189
gene id: 13616:LOC100027189
uniprot id: F7FK22
names: Subcellular Location Annotation
messages: Membrane

13616:POPC1
gene id: 13616:POPC1
uniprot id: Q28464
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

13616:LOC100012766
gene id: 13616:LOC100012766
uniprot id: A0A5F8H1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CXXC1
gene id: 13616:CXXC1
uniprot id: F6YRK9
names: Subcellular Location Annotation
messages: Nucleus

13616:POU6F1
gene id: 13616:POU6F1
uniprot id: H9H8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

13616:ADGRF5
gene id: 13616:ADGRF5
uniprot id: A0A5F8G938
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

13616:PRIM2
gene id: 13616:PRIM2
uniprot id: F7FCC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

13616:STXBP3
gene id: 13616:STXBP3
uniprot id: A0A5F8GMQ2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

13616:UCHL1
gene id: 13616:UCHL1
uniprot id: P50103
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
messages: Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).
messages: O-glycosylated.
messages: The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.
messages: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

13616:AP1G1
gene id: 13616:AP1G1
uniprot id: F7EH71
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:ALB
gene id: 13616:ALB
uniprot id: F7BJP5
names: Subcellular Location Annotation
messages: Secreted

13616:TP53RK
gene id: 13616:TP53RK
uniprot id: K7DZC6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

13616:HIGD2A
gene id: 13616:HIGD2A
uniprot id: F7A2A2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

13616:RSL24D1
gene id: 13616:RSL24D1
uniprot id: A0A5F8H690
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

13616:VHL
gene id: 13616:VHL
uniprot id: F7CGX6
names: Similarity
messages: Belongs to the VHL family.

13616:LOC100025990
gene id: 13616:LOC100025990
uniprot id: F6ZD60
names: Similarity
messages: Belongs to the MHC class II family.

13616:GPR135
gene id: 13616:GPR135
uniprot id: F7F6Y8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:COG1
gene id: 13616:COG1
uniprot id: F7F869
names: Similarity
messages: Belongs to the COG1 family.

13616:LOC100021550
gene id: 13616:LOC100021550
uniprot id: F6VIN8
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

13616:SENP3
gene id: 13616:SENP3
uniprot id: A0A5F8H0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

13616:ERCC2
gene id: 13616:ERCC2
uniprot id: F7DF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

13616:ITGA2B
gene id: 13616:ITGA2B
uniprot id: F6RI44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:DENR
gene id: 13616:DENR
uniprot id: A0A5F8GGX6
names: Similarity
messages: Belongs to the DENR family.

13616:ADCY7
gene id: 13616:ADCY7
uniprot id: F7G158
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:CAMK1
gene id: 13616:CAMK1
uniprot id: F6YQ84
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ASZ1
gene id: 13616:ASZ1
uniprot id: F6Z443
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.

13616:LOC100024824
gene id: 13616:LOC100024824
uniprot id: F7GII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DTNB
gene id: 13616:DTNB
uniprot id: A0A5F8G2N2
uniprot id: A0A5F8GMX5
uniprot id: F7F0G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

13616:ANKRD34A
gene id: 13616:ANKRD34A
uniprot id: F7EF13
names: Similarity
messages: Belongs to the ANKRD34 family.

13616:PYGL
gene id: 13616:PYGL
uniprot id: F7ACG9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

13616:CCNB2
gene id: 13616:CCNB2
uniprot id: F7CU79
names: Similarity
messages: Belongs to the cyclin family.

13616:LOC100024559
gene id: 13616:LOC100024559
uniprot id: F6YSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ALPL
gene id: 13616:ALPL
uniprot id: F7EGD2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

13616:MTFR2
gene id: 13616:MTFR2
uniprot id: F6Z5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

13616:COPG2
gene id: 13616:COPG2
uniprot id: A0A5F8G5D4
uniprot id: F7F762
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:ACKR1
gene id: 13616:ACKR1
uniprot id: A0A5F8HGN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

13616:LOC100021916
gene id: 13616:LOC100021916
uniprot id: A0A5F8GHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EEF1B2
gene id: 13616:EEF1B2
uniprot id: F7EG66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

13616:SYNDIG1
gene id: 13616:SYNDIG1
uniprot id: F7CAE5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:NLGN1
gene id: 13616:NLGN1
uniprot id: D2X2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

13616:PPP4C
gene id: 13616:PPP4C
uniprot id: F7E0S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

13616:CHAC2
gene id: 13616:CHAC2
uniprot id: A0A5F8G8Z6
uniprot id: F7BBA1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

13616:CTSZ
gene id: 13616:CTSZ
uniprot id: F6ZD89
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:PGLS
gene id: 13616:PGLS
uniprot id: F6SVN1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

13616:LOC100015908
gene id: 13616:LOC100015908
uniprot id: F7C9Z1
names: Similarity
messages: Belongs to the transferrin family.

13616:VN2R650
gene id: 13616:VN2R650
uniprot id: A0A5F8HAF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:BPNT1
gene id: 13616:BPNT1
uniprot id: A0A5F8GZC1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:BARHL1
gene id: 13616:BARHL1
uniprot id: F6PNM9
names: Subcellular Location Annotation
messages: Nucleus

13616:ITPR2
gene id: 13616:ITPR2
uniprot id: F6ZCW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

13616:ALKBH1
gene id: 13616:ALKBH1
uniprot id: F7GGQ9
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

13616:AAR2
gene id: 13616:AAR2
uniprot id: F7BCP7
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

13616:NUDT12
gene id: 13616:NUDT12
uniprot id: F6XSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

13616:LOC100022215
gene id: 13616:LOC100022215
uniprot id: F6ZVZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

13616:YME1L1
gene id: 13616:YME1L1
uniprot id: F7BVC8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:TIPIN
gene id: 13616:TIPIN
uniprot id: F6XSL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

13616:CENPK
gene id: 13616:CENPK
uniprot id: A0A5F8H2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

13616:NKD1
gene id: 13616:NKD1
uniprot id: A0A5F8HC55
uniprot id: F7FQ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

13616:SNTG1
gene id: 13616:SNTG1
uniprot id: F6UUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

13616:LOC100016683
gene id: 13616:LOC100016683
uniprot id: F6WJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:TGFA
gene id: 13616:TGFA
uniprot id: F6QBL8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ZNF503
gene id: 13616:ZNF503
uniprot id: A0A5F8GKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

13616:LOC100023218
gene id: 13616:LOC100023218
uniprot id: A0A5F8GB64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100014318
gene id: 13616:LOC100014318
uniprot id: F7ASF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:YWHAQ
gene id: 13616:YWHAQ
uniprot id: F6ZC14
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:ARID3A
gene id: 13616:ARID3A
uniprot id: F6V3G3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

13616:LOC100031170
gene id: 13616:LOC100031170
uniprot id: A0A5F8GN48
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

13616:SLC29A3
gene id: 13616:SLC29A3
uniprot id: F6PVB3
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

13616:LOC100013114
gene id: 13616:LOC100013114
uniprot id: F6VTP9
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:PRKAR2A
gene id: 13616:PRKAR2A
uniprot id: A0A5F8GKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

13616:PKD2L2
gene id: 13616:PKD2L2
uniprot id: F6YGJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

13616:MARCHF11
gene id: 13616:MARCHF11
uniprot id: F7DWW8
names: Subcellular Location Annotation
messages: Membrane

13616:PTGER2
gene id: 13616:PTGER2
uniprot id: F7A5D2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TNFAIP1
gene id: 13616:TNFAIP1
uniprot id: A0A5F8GQD3
names: Similarity
messages: Belongs to the BACURD family.

13616:LOC100012075
gene id: 13616:LOC100012075
uniprot id: H9H7T2
names: Similarity
messages: Belongs to the intermediate filament family.

13616:SIKE1
gene id: 13616:SIKE1
uniprot id: F6TQ91
names: Similarity
messages: Belongs to the SIKE family.

13616:EDNRB
gene id: 13616:EDNRB
uniprot id: F7F4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KAT8
gene id: 13616:KAT8
uniprot id: F6SP03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

13616:NELFE
gene id: 13616:NELFE
uniprot id: F7FHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

13616:GK
gene id: 13616:GK
uniprot id: F7EGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

13616:HSD3B7
gene id: 13616:HSD3B7
uniprot id: F6WZW9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

13616:RPRD1B
gene id: 13616:RPRD1B
uniprot id: A0A5F8H8W1
uniprot id: F6SZY6
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

13616:PLXNB3
gene id: 13616:PLXNB3
uniprot id: F6PJL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CA7
gene id: 13616:CA7
uniprot id: F6PGF8
uniprot id: F6PGJ3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:LOC100028071
gene id: 13616:LOC100028071
uniprot id: F7G822
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:DUSP29
gene id: 13616:DUSP29
uniprot id: A0A5F8G707
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:PMS1
gene id: 13616:PMS1
uniprot id: F6QXE7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

13616:FGFR4
gene id: 13616:FGFR4
uniprot id: F7C211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:LOC100619965
gene id: 13616:LOC100619965
uniprot id: A0A5F8H2K5
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

13616:ORAI1
gene id: 13616:ORAI1
uniprot id: A0A5F8GMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

13616:CACNA1S
gene id: 13616:CACNA1S
uniprot id: F7AXC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

13616:UCK1
gene id: 13616:UCK1
uniprot id: F6PHT3
names: Similarity
messages: Belongs to the uridine kinase family.

13616:RPL14
gene id: 13616:RPL14
uniprot id: F6U375
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

13616:OSGEPL1
gene id: 13616:OSGEPL1
uniprot id: A0A5F8H593
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

13616:GIMD1
gene id: 13616:GIMD1
uniprot id: K7E119
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:LOC100024446
gene id: 13616:LOC100024446
uniprot id: A0A5F8GFR1
uniprot id: F7AYT6
names: Subcellular Location Annotation
messages: nucleoplasm

13616:B9D2
gene id: 13616:B9D2
uniprot id: F6PGL5
names: Subcellular Location Annotation
messages: cilium basal body

13616:GUCY2C
gene id: 13616:GUCY2C
uniprot id: F7B751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

13616:LOC100017609
gene id: 13616:LOC100017609
uniprot id: A0A5F8GHY5
names: Similarity
messages: Belongs to the CRISP family.

13616:LOC100013589
gene id: 13616:LOC100013589
uniprot id: F7EEM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:NRP2
gene id: 13616:NRP2
uniprot id: A0A5F8H1I4
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MMAB
gene id: 13616:MMAB
uniprot id: F6V9Y7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

13616:VPS37C
gene id: 13616:VPS37C
uniprot id: F7FWK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

13616:RRP8
gene id: 13616:RRP8
uniprot id: A0A5F8G639
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

13616:UCK2
gene id: 13616:UCK2
uniprot id: F7FW97
names: Similarity
messages: Belongs to the uridine kinase family.

13616:LOC100026408
gene id: 13616:LOC100026408
uniprot id: A0A5F8H6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DDX31
gene id: 13616:DDX31
uniprot id: A0A5F8GZ27
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

13616:CCDC181
gene id: 13616:CCDC181
uniprot id: F6PNZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

13616:LOC100015172
gene id: 13616:LOC100015172
uniprot id: F6VI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

13616:RRM2B
gene id: 13616:RRM2B
uniprot id: F6SL91
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

13616:NR4A3
gene id: 13616:NR4A3
uniprot id: F6VYB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:VEPH1
gene id: 13616:VEPH1
uniprot id: F7E0U4
names: Similarity
messages: Belongs to the MELT/VEPH family.

13616:GCLM
gene id: 13616:GCLM
uniprot id: A0A5F8H8N6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

13616:GOLT1B
gene id: 13616:GOLT1B
uniprot id: A0A5F8GGP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

13616:BYSL
gene id: 13616:BYSL
uniprot id: F7DYQ6
names: Similarity
messages: Belongs to the bystin family.

13616:NME3
gene id: 13616:NME3
uniprot id: F7DRU3
names: Similarity
messages: Belongs to the NDK family.

13616:HOXD9
gene id: 13616:HOXD9
uniprot id: F7A9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:GRM3
gene id: 13616:GRM3
uniprot id: F6V5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

13616:LOC103098663
gene id: 13616:LOC103098663
uniprot id: F6YSK2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:JAGN1
gene id: 13616:JAGN1
uniprot id: F6ZCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PER1
gene id: 13616:PER1
uniprot id: F7AX09
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:GNB3
gene id: 13616:GNB3
uniprot id: F7CXD0
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:LOC100029767
gene id: 13616:LOC100029767
uniprot id: F7A7I3
names: Similarity
messages: Belongs to the actin family.

13616:ME2
gene id: 13616:ME2
uniprot id: F7BC34
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

13616:NAPB
gene id: 13616:NAPB
uniprot id: F7FDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

13616:SLC10A3
gene id: 13616:SLC10A3
uniprot id: F6QFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:ITPRIP
gene id: 13616:ITPRIP
uniprot id: F7FAS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

13616:RPAP2
gene id: 13616:RPAP2
uniprot id: F7A3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

13616:SCNN1B
gene id: 13616:SCNN1B
uniprot id: F6PGF0
names: Subcellular Location Annotation
messages: Membrane

13616:TMEM208
gene id: 13616:TMEM208
uniprot id: A0A5F8HBA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

13616:BICD2
gene id: 13616:BICD2
uniprot id: F6PIY7
names: Similarity
messages: Belongs to the BicD family.

13616:SLC12A6
gene id: 13616:SLC12A6
uniprot id: A0A5F8GEB6
uniprot id: F6X0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:SSH2
gene id: 13616:SSH2
uniprot id: A0A5F8H656
uniprot id: A0A5F8HD36
uniprot id: F6SH18
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

13616:FBXO46
gene id: 13616:FBXO46
uniprot id: K7E0C4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

13616:LOC100028379
gene id: 13616:LOC100028379
uniprot id: F6URR5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:RHOT1
gene id: 13616:RHOT1
uniprot id: F7FMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

13616:AOPEP
gene id: 13616:AOPEP
uniprot id: A0A5F8GQ86
names: Similarity
messages: Belongs to the peptidase M1 family.

13616:APAF1
gene id: 13616:APAF1
uniprot id: F7FNF3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

13616:PCYT2
gene id: 13616:PCYT2
uniprot id: A0A5F8H8T9
uniprot id: F6PLX5
names: Similarity
messages: Belongs to the cytidylyltransferase family.

13616:SDR16C5
gene id: 13616:SDR16C5
uniprot id: A0A5F8G5P3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:PIERCE1
gene id: 13616:PIERCE1
uniprot id: F6VAZ1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

13616:GATA2
gene id: 13616:GATA2
uniprot id: F6ZA02
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC17A5
gene id: 13616:SLC17A5
uniprot id: F7AG80
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100031271
gene id: 13616:LOC100031271
uniprot id: F6RTB1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

13616:NAE1
gene id: 13616:NAE1
uniprot id: F7C8D9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

13616:MYH1
gene id: 13616:MYH1
uniprot id: A0A5F8G5G3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:HHATL
gene id: 13616:HHATL
uniprot id: F6VVX3
names: Subcellular Location Annotation
messages: Membrane

13616:TMEM161B
gene id: 13616:TMEM161B
uniprot id: F7D4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

13616:STX16
gene id: 13616:STX16
uniprot id: A0A5F8GD93
uniprot id: A0A5F8H2H0
names: Similarity
messages: Belongs to the syntaxin family.

13616:JAKMIP2
gene id: 13616:JAKMIP2
uniprot id: A0A5F8GE67
uniprot id: F6TKE6
names: Similarity
messages: Belongs to the JAKMIP family.

13616:LOC103103209
gene id: 13616:LOC103103209
uniprot id: H9H7V0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:PSMB10
gene id: 13616:PSMB10
uniprot id: F7FVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:SLC30A10
gene id: 13616:SLC30A10
uniprot id: F6X6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

13616:MTHFD1
gene id: 13616:MTHFD1
uniprot id: F7BG84
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

13616:LOC100022567
gene id: 13616:LOC100022567
uniprot id: A0A5F8HBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

13616:TPPP3
gene id: 13616:TPPP3
uniprot id: F6WFW6
names: Similarity
messages: Belongs to the TPPP family.

13616:SLC25A48
gene id: 13616:SLC25A48
uniprot id: A0A5F8HI58
uniprot id: F7A5G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100030261
gene id: 13616:LOC100030261
uniprot id: F7CDA3
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100019585
gene id: 13616:LOC100019585
uniprot id: F7EEE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VDAC3
gene id: 13616:VDAC3
uniprot id: F6VI43
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

13616:TTC21B
gene id: 13616:TTC21B
uniprot id: F7EKI1
names: Similarity
messages: Belongs to the TTC21 family.

13616:PHYHIP
gene id: 13616:PHYHIP
uniprot id: F7F9L7
names: Similarity
messages: Belongs to the PHYHIP family.

13616:NPEPPS
gene id: 13616:NPEPPS
uniprot id: F6PLN8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:VAPB
gene id: 13616:VAPB
uniprot id: A0A5F8H466
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:ADRB3
gene id: 13616:ADRB3
uniprot id: F7CIS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

13616:PPIF
gene id: 13616:PPIF
uniprot id: F7D520
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:PSMD12
gene id: 13616:PSMD12
uniprot id: F7DST4
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

13616:ATP6V0E1
gene id: 13616:ATP6V0E1
uniprot id: A0A5F8H4M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:TIMP3
gene id: 13616:TIMP3
uniprot id: A0A5F8G917
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

13616:YTHDF3
gene id: 13616:YTHDF3
uniprot id: F6ZX60
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

13616:ADCY2
gene id: 13616:ADCY2
uniprot id: F6V001
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:MED20
gene id: 13616:MED20
uniprot id: A0A5F8GVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:PPP2CB
gene id: 13616:PPP2CB
uniprot id: F7CP86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

13616:GABRA4
gene id: 13616:GABRA4
uniprot id: F6ZBG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:SGMS2
gene id: 13616:SGMS2
uniprot id: A0A5F8G2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

13616:monDomV1R1258
gene id: 13616:monDomV1R1258
uniprot id: F6Z3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LGSN
gene id: 13616:LGSN
uniprot id: A0A5F8GG75
names: Similarity
messages: Belongs to the glutamine synthetase family.

13616:LOC100020266
gene id: 13616:LOC100020266
uniprot id: A0A5F8G8J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TBCC
gene id: 13616:TBCC
uniprot id: F7FP07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

13616:FSCN3
gene id: 13616:FSCN3
uniprot id: F7B7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

13616:PPP1R1B
gene id: 13616:PPP1R1B
uniprot id: F6S0P8
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

13616:SLC28A3
gene id: 13616:SLC28A3
uniprot id: F7F2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:CPSF6
gene id: 13616:CPSF6
uniprot id: A0A5F8G6G5
uniprot id: A0A5F8H051
uniprot id: F6SH96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

13616:B4GALNT2
gene id: 13616:B4GALNT2
uniprot id: F6YH79
uniprot id: K7E359
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

13616:G6PC1
gene id: 13616:G6PC1
uniprot id: A0A5F8G347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

13616:LOC100033195
gene id: 13616:LOC100033195
uniprot id: F7CKR3
names: Similarity
messages: Belongs to the FAH family.

13616:TMED6
gene id: 13616:TMED6
uniprot id: F6YGQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CFAP36
gene id: 13616:CFAP36
uniprot id: F6WGE6
names: Similarity
messages: Belongs to the CFAP36 family.

13616:TRHR
gene id: 13616:TRHR
uniprot id: F7AUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

13616:AMPD3
gene id: 13616:AMPD3
uniprot id: F7E5A8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

13616:LOC100018630
gene id: 13616:LOC100018630
uniprot id: A0A5F8HDC6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

13616:GC
gene id: 13616:GC
uniprot id: A0A5F8H662
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

13616:CPM
gene id: 13616:CPM
uniprot id: F6RZ59
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:LOC100619918
gene id: 13616:LOC100619918
uniprot id: A0A5F8G8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNX21
gene id: 13616:SNX21
uniprot id: F6ST07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

13616:SHTN1
gene id: 13616:SHTN1
uniprot id: A0A5F8GV46
uniprot id: F7FNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

13616:DNAJC27
gene id: 13616:DNAJC27
uniprot id: A0A5F8G6K7
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

13616:LOC100025197
gene id: 13616:LOC100025197
uniprot id: A0A5F8GCS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MUS81
gene id: 13616:MUS81
uniprot id: F7FIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

13616:GOLM2
gene id: 13616:GOLM2
uniprot id: A0A5F8G5M3
uniprot id: F7FHF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

13616:TRUB1
gene id: 13616:TRUB1
uniprot id: F6SH34
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

13616:EMX2
gene id: 13616:EMX2
uniprot id: F7CPI5
names: Subcellular Location Annotation
messages: Nucleus

13616:EVA1C
gene id: 13616:EVA1C
uniprot id: A0A5F8G984
uniprot id: A0A5F8GQC5
uniprot id: A0A5F8H651
names: Similarity
messages: Belongs to the EVA1 family.

13616:MAPRE2
gene id: 13616:MAPRE2
uniprot id: F7GHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

13616:CAMK2A
gene id: 13616:CAMK2A
uniprot id: F6QSC1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

13616:PLOD3
gene id: 13616:PLOD3
uniprot id: F7ERJ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:CDCA5
gene id: 13616:CDCA5
uniprot id: A0A5F8GKL1
uniprot id: A0A5F8HHF3
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

13616:DCTN4
gene id: 13616:DCTN4
uniprot id: A0A5F8G854
uniprot id: A0A5F8GBW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

13616:EXOC7
gene id: 13616:EXOC7
uniprot id: F7FTY5
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

13616:NATD1
gene id: 13616:NATD1
uniprot id: F7BD69
names: Similarity
messages: Belongs to the NATD1 family.

13616:MAP3K8
gene id: 13616:MAP3K8
uniprot id: F7EA12
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:GRAMD1C
gene id: 13616:GRAMD1C
uniprot id: F7CCG4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:RHBDF2
gene id: 13616:RHBDF2
uniprot id: F7DQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

13616:ATP6V1C2
gene id: 13616:ATP6V1C2
uniprot id: A0A5F8GRV1
uniprot id: F7DMB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

13616:POLR1F
gene id: 13616:POLR1F
uniprot id: F7F5A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

13616:SP4
gene id: 13616:SP4
uniprot id: A0A5F8G4P1
names: Subcellular Location Annotation
messages: Nucleus

13616:GPR3
gene id: 13616:GPR3
uniprot id: A0A5F8GDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TTC39C
gene id: 13616:TTC39C
uniprot id: F7G2N9
names: Similarity
messages: Belongs to the TTC39 family.

13616:LOC100022053
gene id: 13616:LOC100022053
uniprot id: A0A5F8H537
uniprot id: F6U0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

13616:KAT7
gene id: 13616:KAT7
uniprot id: F7DHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

13616:TGIF2
gene id: 13616:TGIF2
uniprot id: A0A5F8GEI0
uniprot id: A0A5F8HCK7
names: Subcellular Location Annotation
messages: Nucleus

13616:GDF7
gene id: 13616:GDF7
uniprot id: A0A5F8GL90
names: Similarity
messages: Belongs to the TGF-beta family.

13616:SUGP2
gene id: 13616:SUGP2
uniprot id: F7DSD1
names: Subcellular Location Annotation
messages: Nucleus

13616:CACTIN
gene id: 13616:CACTIN
uniprot id: F6PFY9
names: Similarity
messages: Belongs to the CACTIN family.

13616:XPO5
gene id: 13616:XPO5
uniprot id: F7G0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

13616:ADCY3
gene id: 13616:ADCY3
uniprot id: F7B3B0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:TLX1
gene id: 13616:TLX1
uniprot id: F7EGZ4
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100022248
gene id: 13616:LOC100022248
uniprot id: F6Q020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PSMA7
gene id: 13616:PSMA7
uniprot id: F6WS89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:MTR
gene id: 13616:MTR
uniprot id: F7DB09
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

13616:ZIC3
gene id: 13616:ZIC3
uniprot id: F6V8L0
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

13616:DAZL
gene id: 13616:DAZL
uniprot id: A0A5F8GPT9
uniprot id: F6ZCR3
uniprot id: K7E074
names: Subcellular Location Annotation
messages: Cytoplasm

13616:LOC100020394
gene id: 13616:LOC100020394
uniprot id: A0A5F8HBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:THNSL1
gene id: 13616:THNSL1
uniprot id: F6WJR7
names: Similarity
messages: Belongs to the threonine synthase family.

13616:BBS7
gene id: 13616:BBS7
uniprot id: F7GJV3
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

13616:GALC
gene id: 13616:GALC
uniprot id: A0A5F8GXE9
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

13616:DESI2
gene id: 13616:DESI2
uniprot id: F7CDN2
names: Similarity
messages: Belongs to the DeSI family.

13616:KRT20
gene id: 13616:KRT20
uniprot id: F7C2V3
names: Similarity
messages: Belongs to the intermediate filament family.

13616:DAG1
gene id: 13616:DAG1
uniprot id: A0A5F8GMJ7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

13616:LOC100018896
gene id: 13616:LOC100018896
uniprot id: F6V6W6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103105104
gene id: 13616:LOC103105104
uniprot id: F6RJI9
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

13616:FOXA2
gene id: 13616:FOXA2
uniprot id: F7FSC5
names: Subcellular Location Annotation
messages: Nucleus

13616:OPN3
gene id: 13616:OPN3
uniprot id: F6RGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:RBX1
gene id: 13616:RBX1
uniprot id: F7G0U6
names: Similarity
messages: Belongs to the RING-box family.

13616:ZHX3
gene id: 13616:ZHX3
uniprot id: F6TAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

13616:CES1
gene id: 13616:CES1
uniprot id: A0A5F8G7D6
uniprot id: F6TPH0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

13616:AMFR
gene id: 13616:AMFR
uniprot id: A0A5F8GEK6
uniprot id: F7DTS8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100030236
gene id: 13616:LOC100030236
uniprot id: F6VQ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HOXD13
gene id: 13616:HOXD13
uniprot id: F7BJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:SELP
gene id: 13616:SELP
uniprot id: F6WDI7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:RBCK1
gene id: 13616:RBCK1
uniprot id: F6VDA7
names: Similarity
messages: Belongs to the RBR family.

13616:NIBAN2
gene id: 13616:NIBAN2
uniprot id: F6Y3H2
names: Similarity
messages: Belongs to the Niban family.

13616:LOC100015828
gene id: 13616:LOC100015828
uniprot id: F6W669
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

13616:LOC100014394
gene id: 13616:LOC100014394
uniprot id: F7CQT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

13616:TMEM186
gene id: 13616:TMEM186
uniprot id: F6QE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

13616:LOC100029725
gene id: 13616:LOC100029725
uniprot id: F6UHH2
names: Similarity
messages: Belongs to the BicD family.

13616:MRPL15
gene id: 13616:MRPL15
uniprot id: F7G026
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

13616:DEGS2
gene id: 13616:DEGS2
uniprot id: A0A5F8GGF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:RPIA
gene id: 13616:RPIA
uniprot id: F6QSF2
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

13616:POLB
gene id: 13616:POLB
uniprot id: F6STA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

13616:BCL9
gene id: 13616:BCL9
uniprot id: A0A5F8HDI8
uniprot id: F7EFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

13616:MAPK3
gene id: 13616:MAPK3
uniprot id: F7EI48
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

13616:MAPRE3
gene id: 13616:MAPRE3
uniprot id: A0A5F8GKD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

13616:ALOX12B
gene id: 13616:ALOX12B
uniprot id: F7FZA5
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MED4
gene id: 13616:MED4
uniprot id: F6SQB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:CNOT1
gene id: 13616:CNOT1
uniprot id: F6TR11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

13616:ALDH4A1
gene id: 13616:ALDH4A1
uniprot id: H9H7P9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:STEEP1
gene id: 13616:STEEP1
uniprot id: A0A5F8GCG9
uniprot id: F6ST98
names: Similarity
messages: Belongs to the STEEP1 family.

13616:SULF1
gene id: 13616:SULF1
uniprot id: A0A5F8HI11
uniprot id: F7DW81
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

13616:LOC100022496
gene id: 13616:LOC100022496
uniprot id: F7CU30
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:VN2R539
gene id: 13616:VN2R539
uniprot id: F6W427
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100014968
gene id: 13616:LOC100014968
uniprot id: F7DVI2
names: Subcellular Location Annotation
messages: Membrane

13616:IST1
gene id: 13616:IST1
uniprot id: A0A5F8HDG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

13616:MED6
gene id: 13616:MED6
uniprot id: F6RC94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

13616:SLC27A5
gene id: 13616:SLC27A5
uniprot id: K7E5H1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:OPALIN
gene id: 13616:OPALIN
uniprot id: F6T2B6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

13616:MOCS2
gene id: 13616:MOCS2
uniprot id: F6RWP4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

13616:TRAPPC4
gene id: 13616:TRAPPC4
uniprot id: F7GJ67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

13616:KDELR2
gene id: 13616:KDELR2
uniprot id: F7ETG7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PAIP2B
gene id: 13616:PAIP2B
uniprot id: F6ZAI5
names: Similarity
messages: Belongs to the PAIP2 family.

13616:POLR3B
gene id: 13616:POLR3B
uniprot id: F6WGH7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

13616:CLDN25
gene id: 13616:CLDN25
uniprot id: F6U6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:POLR2B
gene id: 13616:POLR2B
uniprot id: K7E2Q4
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

13616:ACTRT3
gene id: 13616:ACTRT3
uniprot id: F7DSU1
names: Similarity
messages: Belongs to the actin family.

13616:PSMC5
gene id: 13616:PSMC5
uniprot id: F6VUJ1
names: Similarity
messages: Belongs to the AAA ATPase family.

13616:TAMM41
gene id: 13616:TAMM41
uniprot id: F7BSM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

13616:DYDC2
gene id: 13616:DYDC2
uniprot id: K7DYW9
names: Similarity
messages: Belongs to the dpy-30 family.

13616:VN2R639
gene id: 13616:VN2R639
uniprot id: A0A5F8H235
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:MGAT1
gene id: 13616:MGAT1
uniprot id: F7EGJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

13616:SPARC
gene id: 13616:SPARC
uniprot id: A0A5F8HE45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

13616:CCDC85C
gene id: 13616:CCDC85C
uniprot id: A0A5F8H5G2
uniprot id: F6QKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

13616:FAM199X
gene id: 13616:FAM199X
uniprot id: F6W884
names: Similarity
messages: Belongs to the FAM199 family.

13616:MMP23B
gene id: 13616:MMP23B
uniprot id: F7CDE4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CHST14
gene id: 13616:CHST14
uniprot id: A0A5F8H6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:CCNH
gene id: 13616:CCNH
uniprot id: A0A5F8G4C0
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

13616:MMP11
gene id: 13616:MMP11
uniprot id: A0A5F8HAP8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:USP16
gene id: 13616:USP16
uniprot id: F6RKK2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

13616:BRI3
gene id: 13616:BRI3
uniprot id: A0A5F8HI27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

13616:KCNJ13
gene id: 13616:KCNJ13
uniprot id: F6YR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:GDF3
gene id: 13616:GDF3
uniprot id: F7AL60
names: Similarity
messages: Belongs to the TGF-beta family.

13616:LOC100031136
gene id: 13616:LOC100031136
uniprot id: A0A5F8H3A3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ORC1
gene id: 13616:ORC1
uniprot id: F6QFY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

13616:HOPX
gene id: 13616:HOPX
uniprot id: A0A5F8GHL5
names: Subcellular Location Annotation
messages: Nucleus

13616:CER1
gene id: 13616:CER1
uniprot id: F7CG49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:CPB1
gene id: 13616:CPB1
uniprot id: F6TIT0
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:TRIP12
gene id: 13616:TRIP12
uniprot id: A0A5F8GRC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

13616:LOC100026355
gene id: 13616:LOC100026355
uniprot id: F6XCC9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:KCNK1
gene id: 13616:KCNK1
uniprot id: F7DH29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

13616:P2RY13
gene id: 13616:P2RY13
uniprot id: A0A5F8GXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100021456
gene id: 13616:LOC100021456
uniprot id: A0A5F8GJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:SHH
gene id: 13616:SHH
uniprot id: D5KSE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Membrane

13616:VWF
gene id: 13616:VWF
uniprot id: F5XVB7
names: Subcellular Location Annotation
names: Subunit
messages: Multimeric. Interacts with F8.
messages: extracellular matrix

13616:TNFRSF19
gene id: 13616:TNFRSF19
uniprot id: A0A5F8GYZ9
uniprot id: F7AL23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:C2H6orf89
gene id: 13616:C2H6orf89
uniprot id: A0A5F8GHL3
uniprot id: F7F8J5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

13616:COQ9
gene id: 13616:COQ9
uniprot id: F7D6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

13616:NTMT1
gene id: 13616:NTMT1
uniprot id: F7CCN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

13616:LOC100026833
gene id: 13616:LOC100026833
uniprot id: A0A5F8HIQ7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC100619788
gene id: 13616:LOC100619788
uniprot id: F7GG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NAPA
gene id: 13616:NAPA
uniprot id: F6QA54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

13616:PLD5
gene id: 13616:PLD5
uniprot id: F6PGF6
names: Similarity
messages: Belongs to the phospholipase D family.

13616:FAM161A
gene id: 13616:FAM161A
uniprot id: A0A5F8HEL8
names: Similarity
messages: Belongs to the FAM161 family.

13616:BABAM1
gene id: 13616:BABAM1
uniprot id: F7FHA1
names: Subcellular Location Annotation
messages: Nucleus

13616:CILP
gene id: 13616:CILP
uniprot id: F6SSK8
names: Subcellular Location Annotation
messages: extracellular matrix

13616:LOC100013718
gene id: 13616:LOC100013718
uniprot id: A0A5F8HLT6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

13616:LOC100028006
gene id: 13616:LOC100028006
uniprot id: A0A5F8H4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PIGO
gene id: 13616:PIGO
uniprot id: F7AFE5
uniprot id: F7BJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100030411
gene id: 13616:LOC100030411
uniprot id: F7A7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SUPV3L1
gene id: 13616:SUPV3L1
uniprot id: H9H6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

13616:IRX6
gene id: 13616:IRX6
uniprot id: F6Z3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:POMC
gene id: 13616:POMC
uniprot id: Q95J84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

13616:MLF1
gene id: 13616:MLF1
uniprot id: A0A5F8GTJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

13616:LOC100020779
gene id: 13616:LOC100020779
uniprot id: A0A5F8GBN7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

13616:GATA3
gene id: 13616:GATA3
uniprot id: F7BYS6
names: Subcellular Location Annotation
messages: Nucleus

13616:KCNG3
gene id: 13616:KCNG3
uniprot id: F6RUG0
names: Subcellular Location Annotation
messages: Membrane

13616:ELOVL2
gene id: 13616:ELOVL2
uniprot id: A0A5F8GU42
uniprot id: A0A5F8GU88
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:SCN3B
gene id: 13616:SCN3B
uniprot id: F7G1T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

13616:LOC100026112
gene id: 13616:LOC100026112
uniprot id: F7DNL5
names: Similarity
messages: Belongs to the MHC class II family.

13616:DCPS
gene id: 13616:DCPS
uniprot id: F6Y3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

13616:HCAR1
gene id: 13616:HCAR1
uniprot id: F7EJ84
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100013132
gene id: 13616:LOC100013132
uniprot id: F6Z964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:LMOD2
gene id: 13616:LMOD2
uniprot id: F7AK27
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

13616:PLCG2
gene id: 13616:PLCG2
uniprot id: F7BVQ1
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

13616:PRUNE1
gene id: 13616:PRUNE1
uniprot id: A0A5F8GL48
uniprot id: A0A5F8HCR2
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

13616:TIMM8A
gene id: 13616:TIMM8A
uniprot id: F6YEL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

13616:LOC100011249
gene id: 13616:LOC100011249
uniprot id: A0A5F8GLY8
names: Subcellular Location Annotation
messages: Membrane

13616:AMBP
gene id: 13616:AMBP
uniprot id: F7D6H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: extracellular matrix

13616:FAM83E
gene id: 13616:FAM83E
uniprot id: A0A5F8GPH0
names: Similarity
messages: Belongs to the FAM83 family.

13616:AMPD2
gene id: 13616:AMPD2
uniprot id: F6W0Z6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

13616:MID1
gene id: 13616:MID1
uniprot id: F6SKS1
names: Subcellular Location Annotation
messages: cytoskeleton

13616:LPCAT1
gene id: 13616:LPCAT1
uniprot id: F7BCV0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:RHBDD1
gene id: 13616:RHBDD1
uniprot id: A0A5F8GW25
names: Subcellular Location Annotation
messages: Membrane

13616:GPX8
gene id: 13616:GPX8
uniprot id: A0A5F8H4R1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

13616:SLC9A5
gene id: 13616:SLC9A5
uniprot id: F7AJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

13616:UBE2K
gene id: 13616:UBE2K
uniprot id: F7AQ16
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:ADD3
gene id: 13616:ADD3
uniprot id: A0A5F8HGX9
uniprot id: F7DP92
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

13616:LOC100028402
gene id: 13616:LOC100028402
uniprot id: A0A5F8HIZ1
names: Subcellular Location Annotation
messages: Membrane

13616:HYI
gene id: 13616:HYI
uniprot id: F6YYI5
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

13616:LOC100010127
gene id: 13616:LOC100010127
uniprot id: F6REK2
names: Similarity
messages: Belongs to the sulfatase family.

13616:LOC100017133
gene id: 13616:LOC100017133
uniprot id: F7ANY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:TEKT2
gene id: 13616:TEKT2
uniprot id: F7GFM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:MFSD10
gene id: 13616:MFSD10
uniprot id: F7DUZ0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103100592
gene id: 13616:LOC103100592
uniprot id: F7G3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KATNAL1
gene id: 13616:KATNAL1
uniprot id: A0A5F8GX49
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

13616:RPS6KA3
gene id: 13616:RPS6KA3
uniprot id: F6YJ34
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:LECT2
gene id: 13616:LECT2
uniprot id: F7BWL0
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

13616:PSMB1
gene id: 13616:PSMB1
uniprot id: F7F3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:FUT10
gene id: 13616:FUT10
uniprot id: F7FP77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

13616:NUP58
gene id: 13616:NUP58
uniprot id: A0A5F8G4X4
uniprot id: F6PH95
names: Subcellular Location Annotation
messages: nuclear pore complex

13616:SLCO4A1
gene id: 13616:SLCO4A1
uniprot id: F7G693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

13616:GCH1
gene id: 13616:GCH1
uniprot id: F7GE69
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

13616:THSD1
gene id: 13616:THSD1
uniprot id: F7A7B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plasmodium circumsporozoite protein family.
messages: Cell membrane
messages: Cytoplasm
messages: In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
messages: Membrane

13616:SEPTIN10
gene id: 13616:SEPTIN10
uniprot id: A0A5F8HHZ6
uniprot id: F6PI38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

13616:CAMK1D
gene id: 13616:CAMK1D
uniprot id: F6R272
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:GRPR
gene id: 13616:GRPR
uniprot id: F6XXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GLDC
gene id: 13616:GLDC
uniprot id: F6V2Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

13616:LOC100022878
gene id: 13616:LOC100022878
uniprot id: F7D6V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SEMA4A
gene id: 13616:SEMA4A
uniprot id: A0A5F8G4H1
uniprot id: F6VN06
names: Similarity
messages: Belongs to the semaphorin family.

13616:LOC100029952
gene id: 13616:LOC100029952
uniprot id: A0A5F8HKJ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:CA9
gene id: 13616:CA9
uniprot id: F7CQP4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

13616:IMMP1L
gene id: 13616:IMMP1L
uniprot id: F7AX03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

13616:EIF3I
gene id: 13616:EIF3I
uniprot id: F7FEZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

13616:RETN
gene id: 13616:RETN
uniprot id: A0A5F8H0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

13616:LOC100020543
gene id: 13616:LOC100020543
uniprot id: A0A5F8HEI6
uniprot id: F7E8W9
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:BRCC3
gene id: 13616:BRCC3
uniprot id: H9H8T2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

13616:GRIA2
gene id: 13616:GRIA2
uniprot id: A0A5F8GRU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:CACNG4
gene id: 13616:CACNG4
uniprot id: A0A5F8GP97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

13616:LOC100018872
gene id: 13616:LOC100018872
uniprot id: A0A5F8GPL8
names: Similarity
messages: Belongs to the RRM elav family.

13616:ARL9
gene id: 13616:ARL9
uniprot id: F7D1G1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:TMTC3
gene id: 13616:TMTC3
uniprot id: F7EP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

13616:monDomV1R1257
gene id: 13616:monDomV1R1257
uniprot id: A0A5F8GAR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IL16
gene id: 13616:IL16
uniprot id: A0A5F8HCE1
uniprot id: F6WC84
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

13616:C5AR1
gene id: 13616:C5AR1
uniprot id: F7CUC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

13616:MTIF2
gene id: 13616:MTIF2
uniprot id: F6T523
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

13616:LOC130453503
gene id: 13616:LOC130453503
uniprot id: A0A5F8HGG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

13616:TRIM9
gene id: 13616:TRIM9
uniprot id: F7C2Z3
names: Subcellular Location Annotation
messages: cytoskeleton

13616:WASF3
gene id: 13616:WASF3
uniprot id: A0A5F8H125
uniprot id: F6QUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

13616:VN2R563
gene id: 13616:VN2R563
uniprot id: A0A5F8H813
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SLC16A14
gene id: 13616:SLC16A14
uniprot id: F6U0N6
names: Subcellular Location Annotation
messages: Membrane

13616:AFF2
gene id: 13616:AFF2
uniprot id: A0A5F8H9R2
uniprot id: F7F3C1
names: Similarity
messages: Belongs to the AF4 family.

13616:NDUFS2
gene id: 13616:NDUFS2
uniprot id: F7EQ50
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

13616:LOC100028222
gene id: 13616:LOC100028222
uniprot id: A0A5F8HAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GRHL2
gene id: 13616:GRHL2
uniprot id: F7FSL0
names: Subcellular Location Annotation
messages: Nucleus

13616:PAPSS1
gene id: 13616:PAPSS1
uniprot id: A0A5F8GR96
uniprot id: A0A5F8H2X0
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

13616:RAB43
gene id: 13616:RAB43
uniprot id: F7BV02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

13616:LOC100020151
gene id: 13616:LOC100020151
uniprot id: F6YFN1
names: Similarity
messages: Belongs to the argonaute family.

13616:LOC100617650
gene id: 13616:LOC100617650
uniprot id: A0A5F8HHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

13616:MAPK9
gene id: 13616:MAPK9
uniprot id: A0A5F8GYR6
uniprot id: F6WV79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

13616:SLC25A41
gene id: 13616:SLC25A41
uniprot id: F6VJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:STAM2
gene id: 13616:STAM2
uniprot id: F7C3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

13616:AASDHPPT
gene id: 13616:AASDHPPT
uniprot id: F6ZCR9
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

13616:RUVBL1
gene id: 13616:RUVBL1
uniprot id: F7CL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

13616:ALX3
gene id: 13616:ALX3
uniprot id: F6WZK4
names: Subcellular Location Annotation
messages: Nucleus

13616:PEX12
gene id: 13616:PEX12
uniprot id: F7EUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

13616:USP15
gene id: 13616:USP15
uniprot id: F6WKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

13616:LOC100028951
gene id: 13616:LOC100028951
uniprot id: F6R9L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:SLC37A3
gene id: 13616:SLC37A3
uniprot id: F6QNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

13616:PTPN6
gene id: 13616:PTPN6
uniprot id: F7CWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

13616:SSRP1
gene id: 13616:SSRP1
uniprot id: F7ESR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

13616:TMEM70
gene id: 13616:TMEM70
uniprot id: A0A5F8H858
names: Similarity
messages: Belongs to the TMEM70 family.

13616:PALM2AKAP2
gene id: 13616:PALM2AKAP2
uniprot id: A0A5F8G4E3
uniprot id: A0A5F8HEI0
uniprot id: A0A5F8HJB2
uniprot id: F6W529
names: Similarity
messages: Belongs to the paralemmin family.

13616:NUP210
gene id: 13616:NUP210
uniprot id: F6PHA8
names: Similarity
messages: Belongs to the NUP210 family.

13616:LOC100027785
gene id: 13616:LOC100027785
uniprot id: F6SWT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

13616:TGFB2
gene id: 13616:TGFB2
uniprot id: F6XNK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

13616:SEPTIN11
gene id: 13616:SEPTIN11
uniprot id: A0A5F8GLI5
uniprot id: F7GM08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

13616:PSMF1
gene id: 13616:PSMF1
uniprot id: A0A5F8H5X4
uniprot id: F6UUG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

13616:GALNT11
gene id: 13616:GALNT11
uniprot id: F6QH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:ELK3
gene id: 13616:ELK3
uniprot id: F7E9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PDP1
gene id: 13616:PDP1
uniprot id: A0A5F8G9W3
uniprot id: A0A5F8GMV6
names: Similarity
messages: Belongs to the PP2C family.

13616:STON2
gene id: 13616:STON2
uniprot id: F7EW99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

13616:ENPP3
gene id: 13616:ENPP3
uniprot id: F7BSG0
names: Subcellular Location Annotation
messages: Secreted

13616:ADRA1D
gene id: 13616:ADRA1D
uniprot id: F6S411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

13616:OPN1SW
gene id: 13616:OPN1SW
uniprot id: B9MSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

13616:MYOZ2
gene id: 13616:MYOZ2
uniprot id: A0A5F8GPB1
names: Similarity
messages: Belongs to the myozenin family.

13616:MAT2A
gene id: 13616:MAT2A
uniprot id: A0A5F8H250
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

13616:ELOF1
gene id: 13616:ELOF1
uniprot id: F7F290
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

13616:SERP1
gene id: 13616:SERP1
uniprot id: F6T2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

13616:LOC100014148
gene id: 13616:LOC100014148
uniprot id: F6QLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FAM163B
gene id: 13616:FAM163B
uniprot id: F7CRK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

13616:JUN
gene id: 13616:JUN
uniprot id: F7DYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

13616:RAD1
gene id: 13616:RAD1
uniprot id: F7C062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

13616:NPY1R
gene id: 13616:NPY1R
uniprot id: F6YEY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100028314
gene id: 13616:LOC100028314
uniprot id: A0A5F8GSD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PITX1
gene id: 13616:PITX1
uniprot id: A0A5F8H975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:PCSK2
gene id: 13616:PCSK2
uniprot id: F7G632
names: Similarity
messages: Belongs to the peptidase S8 family.

13616:KCNJ10
gene id: 13616:KCNJ10
uniprot id: F6PGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:monDomV1R1260
gene id: 13616:monDomV1R1260
uniprot id: F6V7F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC41A2
gene id: 13616:SLC41A2
uniprot id: F6UGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

13616:LOC100013176
gene id: 13616:LOC100013176
uniprot id: K7E155
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

13616:CACUL1
gene id: 13616:CACUL1
uniprot id: A0A5F8GET1
names: Similarity
messages: Belongs to the cullin family.

13616:TFEC
gene id: 13616:TFEC
uniprot id: F7DUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

13616:PARP11
gene id: 13616:PARP11
uniprot id: F6PTG4
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:B4GAT1
gene id: 13616:B4GAT1
uniprot id: F7EK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:ELAVL2
gene id: 13616:ELAVL2
uniprot id: A0A5F8G6K3
names: Similarity
messages: Belongs to the RRM elav family.

13616:SMU1
gene id: 13616:SMU1
uniprot id: F7DWY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

13616:NEFM
gene id: 13616:NEFM
uniprot id: F7BYP0
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC100011605
gene id: 13616:LOC100011605
uniprot id: F7G1K7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:ANXA5
gene id: 13616:ANXA5
uniprot id: F7GJP3
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

13616:FAM110B
gene id: 13616:FAM110B
uniprot id: F7B486
names: Similarity
messages: Belongs to the FAM110 family.

13616:TRAF2
gene id: 13616:TRAF2
uniprot id: F6WWH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

13616:LOC100022796
gene id: 13616:LOC100022796
uniprot id: F7A7F1
names: Subcellular Location Annotation
messages: Membrane

13616:DNAJA4
gene id: 13616:DNAJA4
uniprot id: F7GDZ8
names: Subcellular Location Annotation
messages: Membrane

13616:CFAP91
gene id: 13616:CFAP91
uniprot id: F6PGW3
names: Similarity
messages: Belongs to the CFAP91 family.

13616:IL15RA
gene id: 13616:IL15RA
uniprot id: A0A5F8HF25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PLA2G2C
gene id: 13616:PLA2G2C
uniprot id: A0A5F8GYW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

13616:LOC100023754
gene id: 13616:LOC100023754
uniprot id: A0A5F8GNF9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

13616:LOC100013141
gene id: 13616:LOC100013141
uniprot id: F7ATB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PMPCB
gene id: 13616:PMPCB
uniprot id: F6WXQ5
names: Similarity
messages: Belongs to the peptidase M16 family.

13616:ARSJ
gene id: 13616:ARSJ
uniprot id: F7DM73
names: Similarity
messages: Belongs to the sulfatase family.

13616:SLC7A5
gene id: 13616:SLC7A5
uniprot id: A0A5F8GGD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

13616:DPM1
gene id: 13616:DPM1
uniprot id: F6XRX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

13616:NDUFV3
gene id: 13616:NDUFV3
uniprot id: F6QYY9
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

13616:MOCS1
gene id: 13616:MOCS1
uniprot id: F7BN00
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

13616:SV2A
gene id: 13616:SV2A
uniprot id: F7DXP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

13616:GDA
gene id: 13616:GDA
uniprot id: F7DIF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

13616:NCF2
gene id: 13616:NCF2
uniprot id: F6XAM8
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

13616:ZNF326
gene id: 13616:ZNF326
uniprot id: F7G549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

13616:COG6
gene id: 13616:COG6
uniprot id: F6SS12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

13616:DDX6
gene id: 13616:DDX6
uniprot id: F7DTA2
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:SCARA5
gene id: 13616:SCARA5
uniprot id: A0A5F8GPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

13616:POLR3K
gene id: 13616:POLR3K
uniprot id: A0A5F8H3N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

13616:LOC100022446
gene id: 13616:LOC100022446
uniprot id: F7A7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PDE6G
gene id: 13616:PDE6G
uniprot id: F7CXV2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

13616:APOBEC1
gene id: 13616:APOBEC1
uniprot id: Q9TUI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 Zn(2+) ion per subunit.
messages: Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:10373583). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (By similarity). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity).
messages: Cytoplasm
messages: Homodimer. Interacts with A1CF; form an mRNA editing complex. Interacts with RBM47; form an mRNA editing complex. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB. Interacts with SYNCRIP.
messages: Nucleus

13616:PPEF1
gene id: 13616:PPEF1
uniprot id: F6TMU4
names: Similarity
messages: Belongs to the PPP phosphatase family.

13616:ACSL5
gene id: 13616:ACSL5
uniprot id: F6VQ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

13616:SLC5A12
gene id: 13616:SLC5A12
uniprot id: F7AKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:LOC100020762
gene id: 13616:LOC100020762
uniprot id: F7EM99
names: Subcellular Location Annotation
messages: Membrane

13616:DLK1
gene id: 13616:DLK1
uniprot id: F6ZLP4
uniprot id: Q2HJK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CNNM3
gene id: 13616:CNNM3
uniprot id: F6YUX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Metal transporter.

13616:ARF4
gene id: 13616:ARF4
uniprot id: A0A5F8HGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

13616:EIF2S2
gene id: 13616:EIF2S2
uniprot id: F7EJH2
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

13616:WRNIP1
gene id: 13616:WRNIP1
uniprot id: F6PFR8
uniprot id: F7DJS2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

13616:SNX4
gene id: 13616:SNX4
uniprot id: A0A5F8H5M8
uniprot id: F6QVT1
names: Similarity
messages: Belongs to the sorting nexin family.

13616:PXMP2
gene id: 13616:PXMP2
uniprot id: F7BWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

13616:PALM
gene id: 13616:PALM
uniprot id: F6ZR04
names: Similarity
messages: Belongs to the paralemmin family.

13616:LOC103094747
gene id: 13616:LOC103094747
uniprot id: K7E641
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:SLC41A3
gene id: 13616:SLC41A3
uniprot id: A0A5F8G970
uniprot id: F7BLA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:THYN1
gene id: 13616:THYN1
uniprot id: F7D0S8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

13616:PARVG
gene id: 13616:PARVG
uniprot id: A0A5F8GP47
uniprot id: F7EHZ3
names: Similarity
messages: Belongs to the parvin family.

13616:GPR50
gene id: 13616:GPR50
uniprot id: A0A5F8GJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ABCD4
gene id: 13616:ABCD4
uniprot id: F7GCU3
names: Subcellular Location Annotation
messages: Membrane

13616:DAPK3
gene id: 13616:DAPK3
uniprot id: A0A5F8HHR2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SLC12A9
gene id: 13616:SLC12A9
uniprot id: F6V5G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:PDC
gene id: 13616:PDC
uniprot id: F6YE86
names: Similarity
messages: Belongs to the phosducin family.

13616:AGMAT
gene id: 13616:AGMAT
uniprot id: F7GBU4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

13616:TAAR9G
gene id: 13616:TAAR9G
uniprot id: A0A5F8HCU4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SLC6A8
gene id: 13616:SLC6A8
uniprot id: F6Z838
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

13616:CHST1
gene id: 13616:CHST1
uniprot id: F6Z900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:NXF1
gene id: 13616:NXF1
uniprot id: F6YJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

13616:LOC100030263
gene id: 13616:LOC100030263
uniprot id: F6SQ46
names: Similarity
messages: Belongs to the peptidase A1 family.

13616:EML6
gene id: 13616:EML6
uniprot id: F6WIY1
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

13616:SPTB
gene id: 13616:SPTB
uniprot id: F6Q881
names: Similarity
messages: Belongs to the spectrin family.

13616:SCUBE2
gene id: 13616:SCUBE2
uniprot id: A0A5F8HH90
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:MFSD14A
gene id: 13616:MFSD14A
uniprot id: F7FAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

13616:TMC7
gene id: 13616:TMC7
uniprot id: F6ZSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

13616:XRCC4
gene id: 13616:XRCC4
uniprot id: F6ZI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

13616:SLC6A1
gene id: 13616:SLC6A1
uniprot id: F6SLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:TRHDE
gene id: 13616:TRHDE
uniprot id: A0A5F8G9Y3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:MFN2
gene id: 13616:MFN2
uniprot id: A0A5F8GXF5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:LOC100033022
gene id: 13616:LOC100033022
uniprot id: A0A5F8GU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:IPO11
gene id: 13616:IPO11
uniprot id: F6Y6Y1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:STAT4
gene id: 13616:STAT4
uniprot id: F7CW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:NOSIP
gene id: 13616:NOSIP
uniprot id: F6UWQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

13616:LOC100023209
gene id: 13616:LOC100023209
uniprot id: F7EAU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP1CB
gene id: 13616:PPP1CB
uniprot id: F7AJD1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.

13616:NOS3
gene id: 13616:NOS3
uniprot id: F6S3S1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

13616:PSMA2
gene id: 13616:PSMA2
uniprot id: A0A5F8HLX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:YPEL5
gene id: 13616:YPEL5
uniprot id: F6VI71
names: Similarity
messages: Belongs to the yippee family.

13616:PLOD1
gene id: 13616:PLOD1
uniprot id: F7FVW8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:HDAC2
gene id: 13616:HDAC2
uniprot id: F6YIM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

13616:CCN2
gene id: 13616:CCN2
uniprot id: F7BSS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:EN1
gene id: 13616:EN1
uniprot id: F7FKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

13616:MYH4
gene id: 13616:MYH4
uniprot id: F7BD45
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:PLD3
gene id: 13616:PLD3
uniprot id: F7FNI6
names: Similarity
messages: Belongs to the phospholipase D family.

13616:DDX5
gene id: 13616:DDX5
uniprot id: F7ECU0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

13616:IMPA1
gene id: 13616:IMPA1
uniprot id: K7E4M7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:PDE1A
gene id: 13616:PDE1A
uniprot id: A0A5F8GTK4
uniprot id: A0A5F8H6Y5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:PPARGC1B
gene id: 13616:PPARGC1B
uniprot id: F6VCD4
names: Subcellular Location Annotation
messages: Nucleus

13616:SEMA4G
gene id: 13616:SEMA4G
uniprot id: F7B995
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100619044
gene id: 13616:LOC100619044
uniprot id: A0A5F8HF59
names: Similarity
messages: Belongs to the intermediate filament family.

13616:TSPAN5
gene id: 13616:TSPAN5
uniprot id: F7BAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:LOC100016975
gene id: 13616:LOC100016975
uniprot id: A0A5F8H3R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DPYSL2
gene id: 13616:DPYSL2
uniprot id: A0A5F8G2L5
uniprot id: F7DMI7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

13616:UBE2G1
gene id: 13616:UBE2G1
uniprot id: F7G2B2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:NSFL1C
gene id: 13616:NSFL1C
uniprot id: A0A5F8GFM0
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

13616:HMBOX1
gene id: 13616:HMBOX1
uniprot id: F6RFE9
names: Subcellular Location Annotation
messages: Nucleus

13616:NFS1
gene id: 13616:NFS1
uniprot id: F7BBK5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

13616:FAM98B
gene id: 13616:FAM98B
uniprot id: F7CK98
names: Similarity
messages: Belongs to the FAM98 family.

13616:LOC100023783
gene id: 13616:LOC100023783
uniprot id: F7A9K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:MAPK7
gene id: 13616:MAPK7
uniprot id: F6YQF9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

13616:RPS26
gene id: 13616:RPS26
uniprot id: H9H9D5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

13616:T2R2
gene id: 13616:T2R2
uniprot id: Q2ABA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:LAMTOR3
gene id: 13616:LAMTOR3
uniprot id: F7DKI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

13616:MPG
gene id: 13616:MPG
uniprot id: F6YNB3
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

13616:SAP18
gene id: 13616:SAP18
uniprot id: F6YIF1
names: Similarity
messages: Belongs to the SAP18 family.

13616:UCP3
gene id: 13616:UCP3
uniprot id: F7DAU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:AGA
gene id: 13616:AGA
uniprot id: F6YVD7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

13616:HOOK1
gene id: 13616:HOOK1
uniprot id: A0A5F8HFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

13616:CD8B
gene id: 13616:CD8B
uniprot id: I6LJ12
names: Subcellular Location Annotation
messages: Membrane

13616:NIPAL2
gene id: 13616:NIPAL2
uniprot id: F7CDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:RELT
gene id: 13616:RELT
uniprot id: F7BLC2
names: Caution
names: Similarity
messages: Belongs to the RELT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SYNGR2
gene id: 13616:SYNGR2
uniprot id: F6SPE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

13616:DTNBP1
gene id: 13616:DTNBP1
uniprot id: F7FK78
names: Similarity
messages: Belongs to the dysbindin family.

13616:SCN3A
gene id: 13616:SCN3A
uniprot id: A0A5F8HFU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

13616:SLC6A17
gene id: 13616:SLC6A17
uniprot id: F6WZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:LOC100617303
gene id: 13616:LOC100617303
uniprot id: F7BMV5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:SEC16A
gene id: 13616:SEC16A
uniprot id: F7B5A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

13616:ULBP-like
gene id: 13616:ULBP-like
uniprot id: D7URV6
names: Similarity
messages: Belongs to the MHC class I family.

13616:FAM20C
gene id: 13616:FAM20C
uniprot id: F7FTS0
names: Similarity
messages: Belongs to the FAM20 family.

13616:OS9
gene id: 13616:OS9
uniprot id: H9H7Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

13616:MR1
gene id: 13616:MR1
uniprot id: F7CDQ3
names: Similarity
messages: Belongs to the MHC class I family.

13616:HIRIP3
gene id: 13616:HIRIP3
uniprot id: F6PIN7
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100617479
gene id: 13616:LOC100617479
uniprot id: F7EI98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:WDR76
gene id: 13616:WDR76
uniprot id: F7EL35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

13616:MCTS1
gene id: 13616:MCTS1
uniprot id: F6RPB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

13616:PSMD7
gene id: 13616:PSMD7
uniprot id: A0A5F8GQ46
names: Similarity
messages: Belongs to the peptidase M67A family.

13616:NR2C1
gene id: 13616:NR2C1
uniprot id: F6Z852
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:NDUFB10
gene id: 13616:NDUFB10
uniprot id: F7FYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

13616:LOC100026919
gene id: 13616:LOC100026919
uniprot id: A0A5F8HJ35
names: Subcellular Location Annotation
messages: Membrane

13616:MAB21L1
gene id: 13616:MAB21L1
uniprot id: F6TNJ5
names: Similarity
messages: Belongs to the mab-21 family.

13616:PRPH
gene id: 13616:PRPH
uniprot id: F6UWF7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC100028856
gene id: 13616:LOC100028856
uniprot id: F7EVQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:PLOD2
gene id: 13616:PLOD2
uniprot id: F6TJE3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:ING3
gene id: 13616:ING3
uniprot id: A0A5F8H7X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:ELP1
gene id: 13616:ELP1
uniprot id: F6S334
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

13616:ANXA9
gene id: 13616:ANXA9
uniprot id: F6YYM0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:LOC100015543
gene id: 13616:LOC100015543
uniprot id: F7CL75
names: Similarity
messages: Belongs to the folate receptor family.

13616:PFKFB1
gene id: 13616:PFKFB1
uniprot id: A0A5F8GVT7
uniprot id: F6SPM4
uniprot id: K7E1I7
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

13616:SLC25A31
gene id: 13616:SLC25A31
uniprot id: F7FU45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:CORT
gene id: 13616:CORT
uniprot id: F7DI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

13616:SLC25A26
gene id: 13616:SLC25A26
uniprot id: F6THA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:EIF2S1
gene id: 13616:EIF2S1
uniprot id: F6RU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

13616:ENTPD5
gene id: 13616:ENTPD5
uniprot id: F7BUY1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:CRYBB2
gene id: 13616:CRYBB2
uniprot id: F7F7L0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:SUCLG1
gene id: 13616:SUCLG1
uniprot id: F6WVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

13616:KCNMB4
gene id: 13616:KCNMB4
uniprot id: F7C066
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

13616:NCEH1
gene id: 13616:NCEH1
uniprot id: A0A5F8G3H2
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:SLC35F4
gene id: 13616:SLC35F4
uniprot id: F7AW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

13616:IFI6
gene id: 13616:IFI6
uniprot id: F7CKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

13616:KIAA2013
gene id: 13616:KIAA2013
uniprot id: F7FJ41
names: Subcellular Location Annotation
messages: Membrane

13616:PMM1
gene id: 13616:PMM1
uniprot id: H9H6Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

13616:TAGLN
gene id: 13616:TAGLN
uniprot id: F6X7N5
names: Similarity
messages: Belongs to the calponin family.

13616:PDGFA
gene id: 13616:PDGFA
uniprot id: A0A5F8GD53
uniprot id: A0A5F8GF15
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:FRRS1
gene id: 13616:FRRS1
uniprot id: F7DU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

13616:CDH15
gene id: 13616:CDH15
uniprot id: F7EBN5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:ITK
gene id: 13616:ITK
uniprot id: F7FTR6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:LOC100020048
gene id: 13616:LOC100020048
uniprot id: A0A5F8HD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:YIF1B
gene id: 13616:YIF1B
uniprot id: F7BM72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

13616:LPAR3
gene id: 13616:LPAR3
uniprot id: A0A5F8GF54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CDCA7
gene id: 13616:CDCA7
uniprot id: F7ADY5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:FAM13A
gene id: 13616:FAM13A
uniprot id: A0A5F8GP38
uniprot id: F6REA1
names: Similarity
messages: Belongs to the FAM13 family.

13616:TRMT13
gene id: 13616:TRMT13
uniprot id: F7B009
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

13616:RHBDL3
gene id: 13616:RHBDL3
uniprot id: A0A5F8G236
uniprot id: F7AX77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

13616:KIF20B
gene id: 13616:KIF20B
uniprot id: F6SHK6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:ALG2
gene id: 13616:ALG2
uniprot id: A0A5F8H4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

13616:NPL
gene id: 13616:NPL
uniprot id: A0A5F8H8K2
uniprot id: F6PUU9
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

13616:MOCOS
gene id: 13616:MOCOS
uniprot id: A0A5F8GKW1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

13616:SRP9
gene id: 13616:SRP9
uniprot id: A0A5F8G7U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

13616:HTR1E
gene id: 13616:HTR1E
uniprot id: F6XI83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MOGAT1
gene id: 13616:MOGAT1
uniprot id: F6XVS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ACTG1
gene id: 13616:ACTG1
uniprot id: A0A5F8GD69
names: Similarity
messages: Belongs to the actin family.

13616:MAN2B1
gene id: 13616:MAN2B1
uniprot id: A0A5F8GWC4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:LOC100015220
gene id: 13616:LOC100015220
uniprot id: A0A5F8GBX2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

13616:GAL3ST4
gene id: 13616:GAL3ST4
uniprot id: A0A5F8G3B3
uniprot id: F6W8W2
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:IGFBP3
gene id: 13616:IGFBP3
uniprot id: F7EV06
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:WNT7B
gene id: 13616:WNT7B
uniprot id: F7EF09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:AHSA2P
gene id: 13616:AHSA2P
uniprot id: F7CC22
names: Similarity
messages: Belongs to the AHA1 family.

13616:LOC100020842
gene id: 13616:LOC100020842
uniprot id: F7EV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:KPNB1
gene id: 13616:KPNB1
uniprot id: F6Q1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

13616:GNA15
gene id: 13616:GNA15
uniprot id: F7EC94
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:TFCP2L1
gene id: 13616:TFCP2L1
uniprot id: F6SYN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

13616:GUF1
gene id: 13616:GUF1
uniprot id: F7A0N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

13616:ZDHHC5
gene id: 13616:ZDHHC5
uniprot id: A0A5F8HGA3
uniprot id: F7EAG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:SFT2D2
gene id: 13616:SFT2D2
uniprot id: A0A5F8HCC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:SLIT3
gene id: 13616:SLIT3
uniprot id: F6RCT0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:LOC100028592
gene id: 13616:LOC100028592
uniprot id: F7AKM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100023139
gene id: 13616:LOC100023139
uniprot id: F7EEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GAR1
gene id: 13616:GAR1
uniprot id: F7E2W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

13616:ST14
gene id: 13616:ST14
uniprot id: F7ASK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CAPN5
gene id: 13616:CAPN5
uniprot id: A0A5F8G4P6
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:LOC100010939
gene id: 13616:LOC100010939
uniprot id: A0A5F8GWI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

13616:ZNRF4
gene id: 13616:ZNRF4
uniprot id: F7D4D2
names: Subcellular Location Annotation
messages: Membrane

13616:LAMTOR1
gene id: 13616:LAMTOR1
uniprot id: F6YJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

13616:LOC100031974
gene id: 13616:LOC100031974
uniprot id: A0A5F8H3B9
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM38A
gene id: 13616:TMEM38A
uniprot id: F7FI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

13616:HYOU1
gene id: 13616:HYOU1
uniprot id: F7GJH2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:LOC100020628
gene id: 13616:LOC100020628
uniprot id: F6S9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PNPLA4
gene id: 13616:PNPLA4
uniprot id: A0A5F8H039
uniprot id: A0A5F8H674
uniprot id: F7F1B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DIPK1B
gene id: 13616:DIPK1B
uniprot id: A0A5F8GIR5
names: Similarity
messages: Belongs to the DIPK family.

13616:SGK1
gene id: 13616:SGK1
uniprot id: A0A5F8GZ56
uniprot id: A0A5F8HJ36
uniprot id: F7F0V9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

13616:LOC100021101
gene id: 13616:LOC100021101
uniprot id: F6RNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MYBL1
gene id: 13616:MYBL1
uniprot id: F7DRE7
names: Subcellular Location Annotation
messages: Nucleus

13616:LRP6
gene id: 13616:LRP6
uniprot id: A0A5F8GGM1
uniprot id: F6PG65
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PRDX2
gene id: 13616:PRDX2
uniprot id: A0A5F8H055
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

13616:ARSG
gene id: 13616:ARSG
uniprot id: A0A5F8GNI3
uniprot id: F6SVG1
names: Similarity
messages: Belongs to the sulfatase family.

13616:MSRA
gene id: 13616:MSRA
uniprot id: A0A5F8G7S7
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

13616:GABRA1
gene id: 13616:GABRA1
uniprot id: F7EUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:LOC100024209
gene id: 13616:LOC100024209
uniprot id: F6YHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

13616:TBRG1
gene id: 13616:TBRG1
uniprot id: F7FAF3
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103092481
gene id: 13616:LOC103092481
uniprot id: H9H7U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

13616:RTF2
gene id: 13616:RTF2
uniprot id: A0A5F8H315
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

13616:CETN2
gene id: 13616:CETN2
uniprot id: A0A5F8HJP8
names: Similarity
messages: Belongs to the centrin family.

13616:IRF3
gene id: 13616:IRF3
uniprot id: F6VVK5
names: Subcellular Location Annotation
messages: Nucleus

13616:LIPH
gene id: 13616:LIPH
uniprot id: F6Z6X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

13616:TMOD4
gene id: 13616:TMOD4
uniprot id: A0A5F8GVB1
names: Subcellular Location Annotation
messages: cytoskeleton

13616:SLC10A1
gene id: 13616:SLC10A1
uniprot id: F6SPY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:TUSC3
gene id: 13616:TUSC3
uniprot id: A0A5F8GJ85
uniprot id: A0A5F8GM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:TNFSF11
gene id: 13616:TNFSF11
uniprot id: F7BYM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

13616:NINJ1
gene id: 13616:NINJ1
uniprot id: A0A5F8GHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

13616:COLGALT1
gene id: 13616:COLGALT1
uniprot id: F6W8D5
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

13616:LOC100024653
gene id: 13616:LOC100024653
uniprot id: A0A5F8H890
uniprot id: F6PZH1
names: Similarity
messages: Belongs to the serpin family.

13616:LOC100617074
gene id: 13616:LOC100617074
uniprot id: F6UYA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100030294
gene id: 13616:LOC100030294
uniprot id: F7CT20
names: Subcellular Location Annotation
messages: Membrane

13616:GPN3
gene id: 13616:GPN3
uniprot id: F6UGC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

13616:LOC100011116
gene id: 13616:LOC100011116
uniprot id: F6W9Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

13616:LOC100027566
gene id: 13616:LOC100027566
uniprot id: F6VRB5
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

13616:CLDN1
gene id: 13616:CLDN1
uniprot id: A0A5F8GD39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:GPR87
gene id: 13616:GPR87
uniprot id: F7GEB2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MYH11
gene id: 13616:MYH11
uniprot id: A0A5F8GU50
uniprot id: A0A5F8HIJ3
uniprot id: F7FAW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:LOC100023923
gene id: 13616:LOC100023923
uniprot id: F6U0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATP2A2
gene id: 13616:ATP2A2
uniprot id: A0A5F8H2Z6
uniprot id: F7GE81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

13616:PERP
gene id: 13616:PERP
uniprot id: F7AJF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

13616:CX3CR1
gene id: 13616:CX3CR1
uniprot id: F7CI96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100028143
gene id: 13616:LOC100028143
uniprot id: F6TEL7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:FBP2
gene id: 13616:FBP2
uniprot id: F7EJ99
names: Similarity
messages: Belongs to the FBPase class 1 family.

13616:VAX1
gene id: 13616:VAX1
uniprot id: F7BKU2
names: Subcellular Location Annotation
messages: Nucleus

13616:ADCYAP1
gene id: 13616:ADCYAP1
uniprot id: A0A5F8G657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

13616:IL1B
gene id: 13616:IL1B
uniprot id: F6SXC0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

13616:HTR7
gene id: 13616:HTR7
uniprot id: F6PWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SPDEF
gene id: 13616:SPDEF
uniprot id: F6SVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:FBXO32
gene id: 13616:FBXO32
uniprot id: F6RIR8
names: Subcellular Location Annotation
messages: Nucleus

13616:ANP32B
gene id: 13616:ANP32B
uniprot id: F6T049
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

13616:HSPB7
gene id: 13616:HSPB7
uniprot id: F6VA14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

13616:PGAP1
gene id: 13616:PGAP1
uniprot id: F7CE20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:SDHB
gene id: 13616:SDHB
uniprot id: F6YGR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

13616:PEX5L
gene id: 13616:PEX5L
uniprot id: A0A5F8GMR7
uniprot id: A0A5F8GT00
uniprot id: A0A5F8H894
uniprot id: F7G3U1
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

13616:LOC100023020
gene id: 13616:LOC100023020
uniprot id: F7DSS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LMBR1L
gene id: 13616:LMBR1L
uniprot id: H9H780
names: Similarity
messages: Belongs to the LIMR family.

13616:NGDN
gene id: 13616:NGDN
uniprot id: A0A5F8HEN7
uniprot id: F6TVY4
names: Subcellular Location Annotation
messages: nucleolus

13616:PROK2
gene id: 13616:PROK2
uniprot id: A0A5F8HE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

13616:LOC100014880
gene id: 13616:LOC100014880
uniprot id: F6Z1Q5
names: Subcellular Location Annotation
messages: Membrane

13616:HPDL
gene id: 13616:HPDL
uniprot id: F7A0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

13616:KCNK17
gene id: 13616:KCNK17
uniprot id: A0A5F8G871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:EEF1A1
gene id: 13616:EEF1A1
uniprot id: F6YDH0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

13616:DHX8
gene id: 13616:DHX8
uniprot id: F7BWD9
names: Subcellular Location Annotation
messages: Nucleus

13616:ARHGEF7
gene id: 13616:ARHGEF7
uniprot id: F6VRF8
names: Subcellular Location Annotation
messages: lamellipodium

13616:DENND6A
gene id: 13616:DENND6A
uniprot id: F6TF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

13616:SLC35A2
gene id: 13616:SLC35A2
uniprot id: F6TCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:FAM110C
gene id: 13616:FAM110C
uniprot id: F6Y1F9
names: Similarity
messages: Belongs to the FAM110 family.

13616:CCNJ
gene id: 13616:CCNJ
uniprot id: F6TN79
names: Similarity
messages: Belongs to the cyclin family.

13616:TMOD2
gene id: 13616:TMOD2
uniprot id: A0A5F8GAC4
names: Subcellular Location Annotation
messages: cytoskeleton

13616:LOC100029982
gene id: 13616:LOC100029982
uniprot id: F6SLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SERPINI1
gene id: 13616:SERPINI1
uniprot id: F7FLY6
names: Similarity
messages: Belongs to the serpin family.

13616:MTHFR
gene id: 13616:MTHFR
uniprot id: A0A5F8GXA9
uniprot id: F7AQ98
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

13616:GLB1L2
gene id: 13616:GLB1L2
uniprot id: A0A5F8H6U6
uniprot id: F7F3M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

13616:PSENEN
gene id: 13616:PSENEN
uniprot id: F6VQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

13616:PLIN4
gene id: 13616:PLIN4
uniprot id: F7DNE7
names: Similarity
messages: Belongs to the perilipin family.

13616:DZIP1L
gene id: 13616:DZIP1L
uniprot id: F7GCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

13616:GNAL
gene id: 13616:GNAL
uniprot id: F7CB49
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

13616:SFTPC
gene id: 13616:SFTPC
uniprot id: F7BJX5
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

13616:monDomV1R1284
gene id: 13616:monDomV1R1284
uniprot id: A0A5F8GIG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100012130
gene id: 13616:LOC100012130
uniprot id: F7BYL6
names: Subcellular Location Annotation
messages: Lysosome

13616:HCK
gene id: 13616:HCK
uniprot id: F6RBD8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:NAPRT
gene id: 13616:NAPRT
uniprot id: F7CI40
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

13616:CREB1
gene id: 13616:CREB1
uniprot id: A0A5F8GN53
uniprot id: A0A5F8HIA8
names: Subcellular Location Annotation
messages: Nucleus

13616:TM4SF5
gene id: 13616:TM4SF5
uniprot id: F7DJD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:GPAT4
gene id: 13616:GPAT4
uniprot id: A0A5F8GPC8
uniprot id: F7F7R1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:USP4
gene id: 13616:USP4
uniprot id: A0A5F8GLS6
uniprot id: F7C8N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

13616:ABRAXAS2
gene id: 13616:ABRAXAS2
uniprot id: A0A5F8H3A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

13616:ASPN
gene id: 13616:ASPN
uniprot id: H9H6T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

13616:ECH1
gene id: 13616:ECH1
uniprot id: F6ZM87
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:SSU72
gene id: 13616:SSU72
uniprot id: F7GEV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

13616:SH3BP5
gene id: 13616:SH3BP5
uniprot id: F7ER25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

13616:FAM32A
gene id: 13616:FAM32A
uniprot id: F7G6F7
names: Similarity
messages: Belongs to the FAM32 family.

13616:MAPK10
gene id: 13616:MAPK10
uniprot id: A0A5F8G214
uniprot id: F6ZA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

13616:PRR5L
gene id: 13616:PRR5L
uniprot id: F6YHY4
names: Similarity
messages: Belongs to the PROTOR family.

13616:NR5A2
gene id: 13616:NR5A2
uniprot id: A0A5F8GP12
uniprot id: A0A5F8GP94
uniprot id: F7DCK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

13616:PIGV
gene id: 13616:PIGV
uniprot id: F6SRF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

13616:F2RL3
gene id: 13616:F2RL3
uniprot id: M9MMH7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SPON1
gene id: 13616:SPON1
uniprot id: F7EHN2
names: Subcellular Location Annotation
messages: extracellular matrix

13616:SUV39H2
gene id: 13616:SUV39H2
uniprot id: A0A5F8G1N6
uniprot id: F6VMZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

13616:SFT2D3
gene id: 13616:SFT2D3
uniprot id: F6UC97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

13616:PPFIBP2
gene id: 13616:PPFIBP2
uniprot id: A0A5F8GCI6
uniprot id: A0A5F8GK62
uniprot id: A0A5F8HID2
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

13616:NCK2
gene id: 13616:NCK2
uniprot id: F7ALW1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

13616:HENMT1
gene id: 13616:HENMT1
uniprot id: A0A5F8H3T7
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

13616:EVA1B
gene id: 13616:EVA1B
uniprot id: F6ZXB4
names: Similarity
messages: Belongs to the EVA1 family.

13616:TRAPPC1
gene id: 13616:TRAPPC1
uniprot id: F7G005
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

13616:SEMA3C
gene id: 13616:SEMA3C
uniprot id: F6VKW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:UGCG
gene id: 13616:UGCG
uniprot id: F7FHW3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

13616:DDX43
gene id: 13616:DDX43
uniprot id: F7GCW4
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:OSBP
gene id: 13616:OSBP
uniprot id: F7G832
names: Similarity
messages: Belongs to the OSBP family.

13616:AMD1
gene id: 13616:AMD1
uniprot id: F7EKD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

13616:GATA4
gene id: 13616:GATA4
uniprot id: F7B924
names: Subcellular Location Annotation
messages: Nucleus

13616:UHRF2
gene id: 13616:UHRF2
uniprot id: F6UK80
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

13616:RASSF1
gene id: 13616:RASSF1
uniprot id: A0A5F8H5U5
names: Subcellular Location Annotation
messages: cytoskeleton

13616:ELOVL7
gene id: 13616:ELOVL7
uniprot id: F6QM63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

13616:PLD4
gene id: 13616:PLD4
uniprot id: F6TEV9
names: Similarity
messages: Belongs to the phospholipase D family.

13616:SETD3
gene id: 13616:SETD3
uniprot id: F7DB85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

13616:MVK
gene id: 13616:MVK
uniprot id: F6VQR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

13616:TEF
gene id: 13616:TEF
uniprot id: A0A5F8GW66
uniprot id: A0A5F8H621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

13616:CCNDBP1
gene id: 13616:CCNDBP1
uniprot id: A0A5F8GTB2
uniprot id: F6Z7U3
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

13616:HYAL3
gene id: 13616:HYAL3
uniprot id: F7CYI5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:FZD3
gene id: 13616:FZD3
uniprot id: F6PWM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:FITM1
gene id: 13616:FITM1
uniprot id: F7GBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

13616:LOC100018556
gene id: 13616:LOC100018556
uniprot id: F6TJB1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

13616:HACD2
gene id: 13616:HACD2
uniprot id: F6PRX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:ABCD3
gene id: 13616:ABCD3
uniprot id: A0A5F8HC77
uniprot id: A0A5F8HKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

13616:LOC103102448
gene id: 13616:LOC103102448
uniprot id: K7DZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:DYRK4
gene id: 13616:DYRK4
uniprot id: F6PWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

13616:PRMT3
gene id: 13616:PRMT3
uniprot id: A0A5F8G2M3
names: Subcellular Location Annotation
messages: Cytoplasm

13616:MTMR2
gene id: 13616:MTMR2
uniprot id: A0A5F8G3Y0
uniprot id: A0A5F8HDZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

13616:FGG
gene id: 13616:FGG
uniprot id: F7CIN4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

13616:NT5DC3
gene id: 13616:NT5DC3
uniprot id: F7CVK9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:ACTBL2
gene id: 13616:ACTBL2
uniprot id: F6ZZG9
names: Similarity
messages: Belongs to the actin family.

13616:MCU
gene id: 13616:MCU
uniprot id: A0A5F8GW32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

13616:NEUROD1
gene id: 13616:NEUROD1
uniprot id: F7AUR1
names: Subcellular Location Annotation
messages: Nucleus

13616:PIAS4
gene id: 13616:PIAS4
uniprot id: F6SSV5
names: Similarity
messages: Belongs to the PIAS family.

13616:SUGP1
gene id: 13616:SUGP1
uniprot id: F6UEG6
names: Subcellular Location Annotation
messages: Nucleus

13616:LAP3
gene id: 13616:LAP3
uniprot id: F7BHR0
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

13616:NEK8
gene id: 13616:NEK8
uniprot id: A0A5F8GJF8
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

13616:MDFIC
gene id: 13616:MDFIC
uniprot id: F7F0D0
names: Similarity
messages: Belongs to the MDFI family.

13616:NCDN
gene id: 13616:NCDN
uniprot id: F7F334
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

13616:VN2R555
gene id: 13616:VN2R555
uniprot id: A0A5F8GN76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100031277
gene id: 13616:LOC100031277
uniprot id: F7EI80
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

13616:MYH7
gene id: 13616:MYH7
uniprot id: A0A5F8H8U6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:AFM
gene id: 13616:AFM
uniprot id: F7AX94
names: Subcellular Location Annotation
messages: Secreted

13616:LOC100030424
gene id: 13616:LOC100030424
uniprot id: F7GKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MCL1
gene id: 13616:MCL1
uniprot id: F6ZMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: nucleoplasm

13616:LOC100010923
gene id: 13616:LOC100010923
uniprot id: A0A5F8H3Q7
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

13616:TRAPPC13
gene id: 13616:TRAPPC13
uniprot id: A0A5F8G3C5
uniprot id: A0A5F8HBD7
uniprot id: F6UA19
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

13616:GUCY1B1
gene id: 13616:GUCY1B1
uniprot id: F7AMU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

13616:FCER1G
gene id: 13616:FCER1G
uniprot id: F7F5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

13616:CPLANE2
gene id: 13616:CPLANE2
uniprot id: F6THU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

13616:OCEL1
gene id: 13616:OCEL1
uniprot id: F7G5C5
names: Similarity
messages: Belongs to the ELL/occludin family.

13616:LOC100014881
gene id: 13616:LOC100014881
uniprot id: F7C1X6
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:OGDH
gene id: 13616:OGDH
uniprot id: F7DSQ0
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

13616:SUPT20H
gene id: 13616:SUPT20H
uniprot id: F6XMB7
names: Similarity
messages: Belongs to the SPT20 family.

13616:RPL24
gene id: 13616:RPL24
uniprot id: F6W129
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

13616:SDR42E1
gene id: 13616:SDR42E1
uniprot id: F7CET2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

13616:GALNT16
gene id: 13616:GALNT16
uniprot id: F6VPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:CPEB4
gene id: 13616:CPEB4
uniprot id: A0A5F8GSL7
names: Similarity
messages: Belongs to the RRM CPEB family.

13616:ROR2
gene id: 13616:ROR2
uniprot id: F6RDI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:NACC2
gene id: 13616:NACC2
uniprot id: F7E104
names: Subcellular Location Annotation
messages: Nucleus

13616:PDCD5
gene id: 13616:PDCD5
uniprot id: F7E2R5
names: Similarity
messages: Belongs to the PDCD5 family.

13616:TMOD3
gene id: 13616:TMOD3
uniprot id: A0A5F8HFQ7
names: Subcellular Location Annotation
messages: cytoskeleton

13616:GNA12
gene id: 13616:GNA12
uniprot id: F6TFQ0
uniprot id: K7E5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

13616:PTN
gene id: 13616:PTN
uniprot id: F6VS98
names: Similarity
messages: Belongs to the pleiotrophin family.

13616:LOC100026382
gene id: 13616:LOC100026382
uniprot id: F7EED9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

13616:LOC100024720
gene id: 13616:LOC100024720
uniprot id: F7BPG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:DLX3
gene id: 13616:DLX3
uniprot id: F7G4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

13616:NDUFA10
gene id: 13616:NDUFA10
uniprot id: F7F9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

13616:LY75
gene id: 13616:LY75
uniprot id: A0A5F8GXG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PSPH
gene id: 13616:PSPH
uniprot id: A0A5F8GAZ0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

13616:RPL15
gene id: 13616:RPL15
uniprot id: F6YKQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

13616:TRPC3
gene id: 13616:TRPC3
uniprot id: F7GJV8
names: Subcellular Location Annotation
messages: Membrane

13616:OSBPL8
gene id: 13616:OSBPL8
uniprot id: F7FJJ1
names: Similarity
messages: Belongs to the OSBP family.

13616:AP2M1
gene id: 13616:AP2M1
uniprot id: A0A5F8H245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

13616:MMD
gene id: 13616:MMD
uniprot id: F7BZ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:LOC100021543
gene id: 13616:LOC100021543
uniprot id: A0A5F8HFP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HLCS
gene id: 13616:HLCS
uniprot id: A0A5F8H0K9
uniprot id: F6QZU6
names: Similarity
messages: Belongs to the biotin--protein ligase family.

13616:CKS1B
gene id: 13616:CKS1B
uniprot id: F6U382
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

13616:CLDN11
gene id: 13616:CLDN11
uniprot id: F7GIS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:ANAPC2
gene id: 13616:ANAPC2
uniprot id: F6XXR8
names: Similarity
messages: Belongs to the cullin family.

13616:TASOR2
gene id: 13616:TASOR2
uniprot id: F7B3T1
names: Similarity
messages: Belongs to the TASOR family.

13616:LOC100618260
gene id: 13616:LOC100618260
uniprot id: H9H8F1
names: Subcellular Location Annotation
messages: Membrane

13616:HSPA4L
gene id: 13616:HSPA4L
uniprot id: F6YGK6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:GMPPB
gene id: 13616:GMPPB
uniprot id: F7GKQ3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

13616:HSPA5
gene id: 13616:HSPA5
uniprot id: F6WMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

13616:LOC100022210
gene id: 13616:LOC100022210
uniprot id: F7CAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:LOC100024398
gene id: 13616:LOC100024398
uniprot id: A0A5F8HF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100022049
gene id: 13616:LOC100022049
uniprot id: F6W8M3
names: Similarity
messages: Belongs to the ficolin lectin family.

13616:BMPR1B
gene id: 13616:BMPR1B
uniprot id: F6Q8L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

13616:NDUFAF7
gene id: 13616:NDUFAF7
uniprot id: F6ZX82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

13616:LOC100025995
gene id: 13616:LOC100025995
uniprot id: F6SJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:SLC2A8
gene id: 13616:SLC2A8
uniprot id: F6SU86
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:LOC100013604
gene id: 13616:LOC100013604
uniprot id: F6ZDD9
names: Similarity
messages: Belongs to the intermediate filament family.

13616:NUBP1
gene id: 13616:NUBP1
uniprot id: F7GH42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

13616:TM9SF2
gene id: 13616:TM9SF2
uniprot id: F7A9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:VN2R516
gene id: 13616:VN2R516
uniprot id: A0A5F8GCZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SSR1
gene id: 13616:SSR1
uniprot id: K7E2E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

13616:ACTN1
gene id: 13616:ACTN1
uniprot id: F6SUP3
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:LOC100024932
gene id: 13616:LOC100024932
uniprot id: F6PUC5
names: Subcellular Location Annotation
messages: Membrane

13616:MODO-UE
gene id: 13616:MODO-UE
uniprot id: C6ZIV3
names: Similarity
messages: Belongs to the MHC class I family.

13616:KCNT2
gene id: 13616:KCNT2
uniprot id: A0A5F8GKY4
uniprot id: F6YGT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PTGS2
gene id: 13616:PTGS2
uniprot id: F7FSX5
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NEK6
gene id: 13616:NEK6
uniprot id: F6WNU9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SLC9A8
gene id: 13616:SLC9A8
uniprot id: F7A690
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

13616:FSCN1
gene id: 13616:FSCN1
uniprot id: F6ZF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

13616:SHOX
gene id: 13616:SHOX
uniprot id: F6YBL9
names: Subcellular Location Annotation
messages: Nucleus

13616:RPE
gene id: 13616:RPE
uniprot id: F7FDW3
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

13616:PRPSAP1
gene id: 13616:PRPSAP1
uniprot id: F7ADI1
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

13616:LOC100028578
gene id: 13616:LOC100028578
uniprot id: F7EBH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SMAD5
gene id: 13616:SMAD5
uniprot id: F7CFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:IDO2
gene id: 13616:IDO2
uniprot id: B3Y9H9
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

13616:ANAPC16
gene id: 13616:ANAPC16
uniprot id: F6S1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

13616:EIF3H
gene id: 13616:EIF3H
uniprot id: F6RA25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

13616:RPL19
gene id: 13616:RPL19
uniprot id: F6UYZ4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

13616:DEGS1
gene id: 13616:DEGS1
uniprot id: A0A5F8G1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SF3B1
gene id: 13616:SF3B1
uniprot id: A0A5F8GFE7
uniprot id: F6YFZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

13616:MAN2B2
gene id: 13616:MAN2B2
uniprot id: F7B602
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

13616:NCOA2
gene id: 13616:NCOA2
uniprot id: F6ZNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

13616:MANEAL
gene id: 13616:MANEAL
uniprot id: K7E623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:ARL4D
gene id: 13616:ARL4D
uniprot id: F6S4U6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:ERMAP
gene id: 13616:ERMAP
uniprot id: F6QE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

13616:AHCY
gene id: 13616:AHCY
uniprot id: F6Z693
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

13616:PPDPFL
gene id: 13616:PPDPFL
uniprot id: K7E023
names: Similarity
messages: Belongs to the PPDPF family.

13616:DYNLT4
gene id: 13616:DYNLT4
uniprot id: A0A5F8HFR1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

13616:L3HYPDH
gene id: 13616:L3HYPDH
uniprot id: K7E500
names: Similarity
messages: Belongs to the proline racemase family.

13616:EXOSC2
gene id: 13616:EXOSC2
uniprot id: F7FU90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

13616:CIAO2A
gene id: 13616:CIAO2A
uniprot id: F7F5F3
names: Similarity
messages: Belongs to the MIP18 family.

13616:SEPTIN12
gene id: 13616:SEPTIN12
uniprot id: F7AHD6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

13616:MAK16
gene id: 13616:MAK16
uniprot id: F7DL52
names: Similarity
messages: Belongs to the MAK16 family.

13616:CCT6A
gene id: 13616:CCT6A
uniprot id: F7BUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:MAP7D2
gene id: 13616:MAP7D2
uniprot id: A0A5F8GV32
uniprot id: A0A5F8H8D1
uniprot id: F6Y4L1
names: Similarity
messages: Belongs to the MAP7 family.

13616:TXLNG
gene id: 13616:TXLNG
uniprot id: F6QDN1
names: Similarity
messages: Belongs to the taxilin family.

13616:RHOT2
gene id: 13616:RHOT2
uniprot id: F7BZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

13616:GLI2
gene id: 13616:GLI2
uniprot id: A0A5F8GAN0
uniprot id: F6RAQ8
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

13616:NTSR1
gene id: 13616:NTSR1
uniprot id: A0A5F8G8I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KMO
gene id: 13616:KMO
uniprot id: F6Q9U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

13616:KCNK2
gene id: 13616:KCNK2
uniprot id: A0A5F8HD04
uniprot id: F7DDK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:C4H1orf174
gene id: 13616:C4H1orf174
uniprot id: F7F2Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

13616:THOC7
gene id: 13616:THOC7
uniprot id: A0A5F8GWF8
uniprot id: F6Q3G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

13616:SUSD3
gene id: 13616:SUSD3
uniprot id: A0A5F8GKN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100022225
gene id: 13616:LOC100022225
uniprot id: F6Q031
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NR4A2
gene id: 13616:NR4A2
uniprot id: F6SX93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

13616:METAP1
gene id: 13616:METAP1
uniprot id: A0A5F8H2S0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

13616:WNK2
gene id: 13616:WNK2
uniprot id: A0A5F8GGZ4
uniprot id: F6XUM4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

13616:MELK
gene id: 13616:MELK
uniprot id: F7FWS7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

13616:monDomV1R1244
gene id: 13616:monDomV1R1244
uniprot id: A0A5F8GCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PIH1D2
gene id: 13616:PIH1D2
uniprot id: F7C283
names: Similarity
messages: Belongs to the PIH1 family.

13616:NODAL
gene id: 13616:NODAL
uniprot id: F7CYQ7
names: Similarity
messages: Belongs to the TGF-beta family.

13616:WNT9B
gene id: 13616:WNT9B
uniprot id: A0A5F8G2P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:MARS2
gene id: 13616:MARS2
uniprot id: F6PRC1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:IL15
gene id: 13616:IL15
uniprot id: A0A5F8G3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

13616:TOM1L1
gene id: 13616:TOM1L1
uniprot id: A0A5F8GDB9
uniprot id: F7BYB8
names: Similarity
messages: Belongs to the TOM1 family.

13616:SHCBP1L
gene id: 13616:SHCBP1L
uniprot id: F6QUP0
names: Subcellular Location Annotation
messages: spindle

13616:LOC100015398
gene id: 13616:LOC100015398
uniprot id: A0A5F8GP03
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

13616:DNPH1
gene id: 13616:DNPH1
uniprot id: F7FPA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer.
messages: Nucleus

13616:LOC100027598
gene id: 13616:LOC100027598
uniprot id: H9H6U7
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:NRG1
gene id: 13616:NRG1
uniprot id: A0A5F8H9D3
uniprot id: F7CPL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

13616:CNTNAP4
gene id: 13616:CNTNAP4
uniprot id: A0A5F8H0S4
uniprot id: F6STR1
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CRIPT
gene id: 13616:CRIPT
uniprot id: F7ESU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

13616:PPIA
gene id: 13616:PPIA
uniprot id: F7FZ45
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:THRB
gene id: 13616:THRB
uniprot id: A0A5F8G8X0
uniprot id: A0A5F8GH58
uniprot id: F7G6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:LOC100021883
gene id: 13616:LOC100021883
uniprot id: A0A5F8GZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VN2R623
gene id: 13616:VN2R623
uniprot id: A0A5F8HK40
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TECR
gene id: 13616:TECR
uniprot id: F7G517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NKX6-3
gene id: 13616:NKX6-3
uniprot id: F6YT06
names: Subcellular Location Annotation
messages: Nucleus

13616:FGF11
gene id: 13616:FGF11
uniprot id: A0A5F8GP66
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:LOC100012041
gene id: 13616:LOC100012041
uniprot id: F6SSZ9
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

13616:POMGNT1
gene id: 13616:POMGNT1
uniprot id: F6UGR6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

13616:CALHM6
gene id: 13616:CALHM6
uniprot id: F6Z8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:ABAT
gene id: 13616:ABAT
uniprot id: F6XY07
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

13616:ELP5
gene id: 13616:ELP5
uniprot id: F6WSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

13616:AXIN1
gene id: 13616:AXIN1
uniprot id: A0A5F8G304
names: Subcellular Location Annotation
messages: Cytoplasm

13616:UROD
gene id: 13616:UROD
uniprot id: F7BVV4
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

13616:CD79B
gene id: 13616:CD79B
uniprot id: D7F469
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CNOT6
gene id: 13616:CNOT6
uniprot id: F7F909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

13616:CTSW
gene id: 13616:CTSW
uniprot id: F7EY12
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:PEX7
gene id: 13616:PEX7
uniprot id: F6ZV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

13616:ENSA
gene id: 13616:ENSA
uniprot id: F6ZMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

13616:CACNG1
gene id: 13616:CACNG1
uniprot id: F7CLS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

13616:ST8SIA1
gene id: 13616:ST8SIA1
uniprot id: F7ELG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:FAM3B
gene id: 13616:FAM3B
uniprot id: A0A5F8GNJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

13616:MARVELD3
gene id: 13616:MARVELD3
uniprot id: F7CVN3
uniprot id: F7FQM5
names: Subcellular Location Annotation
messages: Membrane

13616:TMEM147
gene id: 13616:TMEM147
uniprot id: F6VBQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

13616:LOC100618665
gene id: 13616:LOC100618665
uniprot id: F7BX16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PARG
gene id: 13616:PARG
uniprot id: F7DIG7
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

13616:LOC100012591
gene id: 13616:LOC100012591
uniprot id: F6QSG0
names: Subcellular Location Annotation
messages: Membrane

13616:MINAR1
gene id: 13616:MINAR1
uniprot id: A0A5F8H4P0
names: Similarity
messages: Belongs to the MINAR family.

13616:CNMD
gene id: 13616:CNMD
uniprot id: F6YNA3
names: Similarity
messages: Belongs to the chondromodulin-1 family.

13616:IFI30
gene id: 13616:IFI30
uniprot id: F6WUX5
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

13616:TP53BP2
gene id: 13616:TP53BP2
uniprot id: A0A5F8GNL0
uniprot id: F6YQ77
names: Subcellular Location Annotation
messages: Nucleus

13616:TRIM54
gene id: 13616:TRIM54
uniprot id: F7E1B1
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

13616:BMP3
gene id: 13616:BMP3
uniprot id: F6YKG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

13616:LOC100022274
gene id: 13616:LOC100022274
uniprot id: F6Q040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:APEX2
gene id: 13616:APEX2
uniprot id: F7CHS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

13616:ENTPD3
gene id: 13616:ENTPD3
uniprot id: F6TMK1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:PSKH2
gene id: 13616:PSKH2
uniprot id: F7ELA1
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CCL19
gene id: 13616:CCL19
uniprot id: F6QYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:FABP2
gene id: 13616:FABP2
uniprot id: F7GAR7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:LOC100015840
gene id: 13616:LOC100015840
uniprot id: H9H789
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:T2R3H
gene id: 13616:T2R3H
uniprot id: Q2ABA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:S1PR2
gene id: 13616:S1PR2
uniprot id: K7E3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SELENBP1
gene id: 13616:SELENBP1
uniprot id: A0A5F8HIR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

13616:LOC103092765
gene id: 13616:LOC103092765
uniprot id: F7DWH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MED23
gene id: 13616:MED23
uniprot id: A0A5F8GSY1
uniprot id: A0A5F8HJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

13616:LASP1
gene id: 13616:LASP1
uniprot id: F6WDS9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

13616:DCAF13
gene id: 13616:DCAF13
uniprot id: F7FHD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

13616:FOXF1
gene id: 13616:FOXF1
uniprot id: F6U913
names: Subcellular Location Annotation
messages: Nucleus

13616:EIF4EBP2
gene id: 13616:EIF4EBP2
uniprot id: F7CYK5
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

13616:LOC100028693
gene id: 13616:LOC100028693
uniprot id: F7ET94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATXN3
gene id: 13616:ATXN3
uniprot id: A0A5F8HC13
names: Subcellular Location Annotation
messages: Nucleus

13616:SEMA4B
gene id: 13616:SEMA4B
uniprot id: F6VD85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SH3BGRL2
gene id: 13616:SH3BGRL2
uniprot id: K7E2N2
names: Similarity
messages: Belongs to the SH3BGR family.

13616:FGD6
gene id: 13616:FGD6
uniprot id: F6W6U6
names: Subcellular Location Annotation
messages: cytoskeleton

13616:CYFIP1
gene id: 13616:CYFIP1
uniprot id: F6XLX5
names: Similarity
messages: Belongs to the CYFIP family.

13616:PPP1R12B
gene id: 13616:PPP1R12B
uniprot id: A0A5F8HE46
uniprot id: F6SBH5
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

13616:PAN3
gene id: 13616:PAN3
uniprot id: A0A5F8GIE9
uniprot id: F7FR09
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

13616:NPY4R2
gene id: 13616:NPY4R2
uniprot id: F6W7S6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:STXBP1
gene id: 13616:STXBP1
uniprot id: A0A5F8GLR2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

13616:CDC37L1
gene id: 13616:CDC37L1
uniprot id: F6TL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

13616:TRPT1
gene id: 13616:TRPT1
uniprot id: H9H6E1
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

13616:GATC
gene id: 13616:GATC
uniprot id: F6WEJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

13616:XCR1
gene id: 13616:XCR1
uniprot id: F7E7R3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:SAXO2
gene id: 13616:SAXO2
uniprot id: A0A5F8GKE8
names: Similarity
messages: Belongs to the FAM154 family.

13616:ABCG2
gene id: 13616:ABCG2
uniprot id: F7ANW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:MEOX1
gene id: 13616:MEOX1
uniprot id: F7BW00
names: Subcellular Location Annotation
messages: Nucleus

13616:CSK
gene id: 13616:CSK
uniprot id: F7GJZ7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:NSUN2
gene id: 13616:NSUN2
uniprot id: F6QCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

13616:NDP
gene id: 13616:NDP
uniprot id: A0A5F8G428
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:GLYR1
gene id: 13616:GLYR1
uniprot id: F7BSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

13616:MKS1
gene id: 13616:MKS1
uniprot id: F6YN29
names: Subcellular Location Annotation
messages: cilium basal body

13616:E2F3
gene id: 13616:E2F3
uniprot id: F6WI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:BLOC1S5
gene id: 13616:BLOC1S5
uniprot id: A0A5F8G6U5
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

13616:LOC100017631
gene id: 13616:LOC100017631
uniprot id: F7DI19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC103098204
gene id: 13616:LOC103098204
uniprot id: F6Z545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:BECN1
gene id: 13616:BECN1
uniprot id: F7FHK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: autophagosome
messages: trans-Golgi network membrane

13616:RPL3
gene id: 13616:RPL3
uniprot id: F7C419
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

13616:RAP2A
gene id: 13616:RAP2A
uniprot id: A0A5F8G780
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

13616:LRP10
gene id: 13616:LRP10
uniprot id: F6ZCI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100617027
gene id: 13616:LOC100617027
uniprot id: A0A5F8GQT6
uniprot id: F7A5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

13616:LOC103100274
gene id: 13616:LOC103100274
uniprot id: A0A5F8GGQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:TULP4
gene id: 13616:TULP4
uniprot id: F7FNH2
names: Similarity
messages: Belongs to the TUB family.

13616:DBNL
gene id: 13616:DBNL
uniprot id: A0A5F8GM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

13616:LOC100023310
gene id: 13616:LOC100023310
uniprot id: F6Q111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SGO2
gene id: 13616:SGO2
uniprot id: F6PKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

13616:LOC100024704
gene id: 13616:LOC100024704
uniprot id: A0A5F8H075
uniprot id: F6RFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

13616:HOMEZ
gene id: 13616:HOMEZ
uniprot id: F7CZK5
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC12A4
gene id: 13616:SLC12A4
uniprot id: A0A5F8G8Z7
uniprot id: F7BNP3
uniprot id: F7GG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:ANO10
gene id: 13616:ANO10
uniprot id: F6UJG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CRMP1
gene id: 13616:CRMP1
uniprot id: F7DXA3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

13616:ENO3
gene id: 13616:ENO3
uniprot id: F7E6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

13616:SLC25A11
gene id: 13616:SLC25A11
uniprot id: F6YLG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100032606
gene id: 13616:LOC100032606
uniprot id: K7E6D5
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:VN2R597
gene id: 13616:VN2R597
uniprot id: F7GHA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:YIPF2
gene id: 13616:YIPF2
uniprot id: F6XWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

13616:RNF146
gene id: 13616:RNF146
uniprot id: A0A5F8HJU6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

13616:LOC100012393
gene id: 13616:LOC100012393
uniprot id: F7BX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:OAF
gene id: 13616:OAF
uniprot id: A0A5F8HEZ6
names: Similarity
messages: Belongs to the OAF family.

13616:EIF2B5
gene id: 13616:EIF2B5
uniprot id: F6VG26
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

13616:NRXN1
gene id: 13616:NRXN1
uniprot id: A0A5F8GGY5
uniprot id: F7BZM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

13616:LOC100013748
gene id: 13616:LOC100013748
uniprot id: F7EEM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:KIZ
gene id: 13616:KIZ
uniprot id: A0A5F8HHZ2
uniprot id: F7EI09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

13616:MS4A13
gene id: 13616:MS4A13
uniprot id: F7G7B2
names: Similarity
messages: Belongs to the MS4A family.

13616:NUP133
gene id: 13616:NUP133
uniprot id: F7G2C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

13616:NCAPH
gene id: 13616:NCAPH
uniprot id: F7FTE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

13616:HPS3
gene id: 13616:HPS3
uniprot id: A0A5F8H5C9
uniprot id: F6T3C1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

13616:CYRIB
gene id: 13616:CYRIB
uniprot id: A0A5F8G463
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

13616:UGDH
gene id: 13616:UGDH
uniprot id: F7AQE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

13616:monDomV1R1261
gene id: 13616:monDomV1R1261
uniprot id: A0A5F8H6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PKN3
gene id: 13616:PKN3
uniprot id: F6TSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

13616:ZP3
gene id: 13616:ZP3
uniprot id: K7DZ89
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

13616:EXTL3
gene id: 13616:EXTL3
uniprot id: A0A5F8H056
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

13616:PARP6
gene id: 13616:PARP6
uniprot id: F6S5M1
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:EIF5
gene id: 13616:EIF5
uniprot id: F7C537
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

13616:MAGOH
gene id: 13616:MAGOH
uniprot id: F6URP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

13616:ARSL
gene id: 13616:ARSL
uniprot id: K7E4E2
names: Similarity
messages: Belongs to the sulfatase family.

13616:PYROXD1
gene id: 13616:PYROXD1
uniprot id: F6ZXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

13616:CBLB
gene id: 13616:CBLB
uniprot id: A0A5F8G7Q1
uniprot id: F6T5M5
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

13616:TBX6
gene id: 13616:TBX6
uniprot id: F7E1E9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:REEP4
gene id: 13616:REEP4
uniprot id: A0A5F8H3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

13616:PLPPR4
gene id: 13616:PLPPR4
uniprot id: F7D869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:EWSR1
gene id: 13616:EWSR1
uniprot id: F6PFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

13616:PGM2L1
gene id: 13616:PGM2L1
uniprot id: F7B0Q5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

13616:ALAS2
gene id: 13616:ALAS2
uniprot id: F7G8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

13616:DDB2
gene id: 13616:DDB2
uniprot id: F6VQA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

13616:RAD51D
gene id: 13616:RAD51D
uniprot id: F7ECH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

13616:KPNA2
gene id: 13616:KPNA2
uniprot id: F7D853
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:DR1
gene id: 13616:DR1
uniprot id: F6UL95
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

13616:TOE1
gene id: 13616:TOE1
uniprot id: F7E0E0
names: Similarity
messages: Belongs to the CAF1 family.

13616:LOC100017083
gene id: 13616:LOC100017083
uniprot id: F6TC73
names: Subcellular Location Annotation
messages: Membrane

13616:ABL2
gene id: 13616:ABL2
uniprot id: F7FED8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:ZDHHC24
gene id: 13616:ZDHHC24
uniprot id: F7E5D5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:PGGT1B
gene id: 13616:PGGT1B
uniprot id: A0A5F8HJM0
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

13616:LOC103103995
gene id: 13616:LOC103103995
uniprot id: K7E1P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:YIPF5
gene id: 13616:YIPF5
uniprot id: F6V7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

13616:TNR
gene id: 13616:TNR
uniprot id: F7BXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

13616:monDomV1R1243
gene id: 13616:monDomV1R1243
uniprot id: A0A5F8GRF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GJA4
gene id: 13616:GJA4
uniprot id: F7E3B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:CLTC
gene id: 13616:CLTC
uniprot id: F7ATX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

13616:YEATS4
gene id: 13616:YEATS4
uniprot id: A0A5F8HEH3
names: Subcellular Location Annotation
messages: Nucleus

13616:HSD17B1
gene id: 13616:HSD17B1
uniprot id: F7G656
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

13616:AOC1
gene id: 13616:AOC1
uniprot id: A0A5F8GIE6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

13616:POLR3G
gene id: 13616:POLR3G
uniprot id: F7FXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

13616:PELI3
gene id: 13616:PELI3
uniprot id: F6Z8P2
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

13616:SERINC2
gene id: 13616:SERINC2
uniprot id: F6V419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

13616:FGF16
gene id: 13616:FGF16
uniprot id: F7D846
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:METTL3
gene id: 13616:METTL3
uniprot id: F7FEI2
names: Similarity
messages: Belongs to the MT-A70-like family.

13616:VRK1
gene id: 13616:VRK1
uniprot id: F6QLF8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SLC51A
gene id: 13616:SLC51A
uniprot id: F6XC44
names: Subcellular Location Annotation
messages: Membrane

13616:SLC35A5
gene id: 13616:SLC35A5
uniprot id: F7F201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:ERBB4
gene id: 13616:ERBB4
uniprot id: F6ZSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

13616:VN2R589
gene id: 13616:VN2R589
uniprot id: A0A5F8HJZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RPL38
gene id: 13616:RPL38
uniprot id: F7FFK1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

13616:RGS7BP
gene id: 13616:RGS7BP
uniprot id: F6XPX0
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

13616:PHTF1
gene id: 13616:PHTF1
uniprot id: F6S9T7
names: Subcellular Location Annotation
messages: Membrane

13616:PARD3
gene id: 13616:PARD3
uniprot id: A0A5F8G5Q7
uniprot id: A0A5F8GG83
uniprot id: A0A5F8GPI3
uniprot id: A0A5F8GU07
uniprot id: A0A5F8GV23
uniprot id: A0A5F8H9F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

13616:FBLN1
gene id: 13616:FBLN1
uniprot id: A0A5F8GND2
uniprot id: F7FCJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:MRPL47
gene id: 13616:MRPL47
uniprot id: A0A5F8GC81
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

13616:IFN2
gene id: 13616:IFN2
uniprot id: A8E6E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:GTPBP8
gene id: 13616:GTPBP8
uniprot id: A0A5F8H165
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

13616:DCLK1
gene id: 13616:DCLK1
uniprot id: A0A5F8GRG3
uniprot id: A0A5F8GWP9
uniprot id: F6QMV8
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

13616:PPAN
gene id: 13616:PPAN
uniprot id: F7EPT2
names: Subcellular Location Annotation
messages: nucleolus

13616:LOC100031312
gene id: 13616:LOC100031312
uniprot id: F6UKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MED26
gene id: 13616:MED26
uniprot id: A0A5F8HCF8
uniprot id: A0A5F8HCS2
uniprot id: A0A5F8HIV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

13616:REV1
gene id: 13616:REV1
uniprot id: F7BD34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

13616:LOC100024663
gene id: 13616:LOC100024663
uniprot id: F6Q355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SPG7
gene id: 13616:SPG7
uniprot id: A0A5F8GN77
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:FDFT1
gene id: 13616:FDFT1
uniprot id: F7FMA5
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

13616:RBP2
gene id: 13616:RBP2
uniprot id: F7BQ22
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:NAGK
gene id: 13616:NAGK
uniprot id: F6SQY9
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

13616:NKD2
gene id: 13616:NKD2
uniprot id: F6S8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

13616:NMNAT3
gene id: 13616:NMNAT3
uniprot id: A0A5F8H2D2
uniprot id: A0A5F8HAW9
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

13616:PDE3A
gene id: 13616:PDE3A
uniprot id: F6YIK3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:OCRL
gene id: 13616:OCRL
uniprot id: A0A5F8GD36
uniprot id: F6PHM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

13616:VN2R630
gene id: 13616:VN2R630
uniprot id: A0A5F8H6H3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100025413
gene id: 13616:LOC100025413
uniprot id: F7FKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HMX2
gene id: 13616:HMX2
uniprot id: F7GAL2
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100023149
gene id: 13616:LOC100023149
uniprot id: F6YLC4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:KLHL15
gene id: 13616:KLHL15
uniprot id: F7F5Y0
names: Subcellular Location Annotation
messages: Nucleus

13616:MTAP
gene id: 13616:MTAP
uniprot id: A0A5F8GH24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

13616:LOC103097786
gene id: 13616:LOC103097786
uniprot id: A0A5F8GT22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CDK1
gene id: 13616:CDK1
uniprot id: F6V3X3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:PRRX1
gene id: 13616:PRRX1
uniprot id: A0A5F8GML0
uniprot id: F7FQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

13616:GLRX
gene id: 13616:GLRX
uniprot id: A0A5F8HC20
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

13616:SMAD9
gene id: 13616:SMAD9
uniprot id: A0A5F8GVH4
uniprot id: F6UAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:ANXA1
gene id: 13616:ANXA1
uniprot id: F7GEB8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

13616:TTI2
gene id: 13616:TTI2
uniprot id: F7E691
names: Similarity
messages: Belongs to the TTI2 family.

13616:KCNG1
gene id: 13616:KCNG1
uniprot id: F7F6U0
names: Subcellular Location Annotation
messages: Membrane

13616:GABRB3
gene id: 13616:GABRB3
uniprot id: A0A5F8GFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:NR1I3
gene id: 13616:NR1I3
uniprot id: F7A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:SOST
gene id: 13616:SOST
uniprot id: A0A5F8GCV4
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:KRT17
gene id: 13616:KRT17
uniprot id: A0A5F8GPU1
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LHB
gene id: 13616:LHB
uniprot id: Q95J85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

13616:SLC26A4
gene id: 13616:SLC26A4
uniprot id: F7F6U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

13616:TM6SF1
gene id: 13616:TM6SF1
uniprot id: F6WSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

13616:CKAP2L
gene id: 13616:CKAP2L
uniprot id: F6X5H0
names: Similarity
messages: Belongs to the CKAP2 family.

13616:TAT
gene id: 13616:TAT
uniprot id: F7CW54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

13616:EXTL2
gene id: 13616:EXTL2
uniprot id: F7DWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

13616:SCRN1
gene id: 13616:SCRN1
uniprot id: F6XZ29
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

13616:MDGA2
gene id: 13616:MDGA2
uniprot id: A0A5F8G7I5
uniprot id: A0A5F8GJL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CNOT11
gene id: 13616:CNOT11
uniprot id: F6X050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

13616:MRI1
gene id: 13616:MRI1
uniprot id: F7G2V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

13616:FAAH2
gene id: 13616:FAAH2
uniprot id: F7F0S7
names: Similarity
messages: Belongs to the amidase family.

13616:TMEM242
gene id: 13616:TMEM242
uniprot id: F6SWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

13616:LOC100012625
gene id: 13616:LOC100012625
uniprot id: F7GGR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STX7
gene id: 13616:STX7
uniprot id: F7E0Z1
names: Similarity
messages: Belongs to the syntaxin family.

13616:AQP11
gene id: 13616:AQP11
uniprot id: F7E9A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

13616:UTS2
gene id: 13616:UTS2
uniprot id: A0A5F8GYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

13616:MEA1
gene id: 13616:MEA1
uniprot id: F7CP91
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

13616:MAPK1IP1L
gene id: 13616:MAPK1IP1L
uniprot id: F7FT59
names: Similarity
messages: Belongs to the MISS family.

13616:RARRES2
gene id: 13616:RARRES2
uniprot id: F7C6M6
names: Subcellular Location Annotation
messages: Secreted

13616:SUFU
gene id: 13616:SUFU
uniprot id: F6RMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

13616:WNT16
gene id: 13616:WNT16
uniprot id: F6WWA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:LOC100023588
gene id: 13616:LOC100023588
uniprot id: F6Q1P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024614
gene id: 13616:LOC100024614
uniprot id: F6SC37
names: Similarity
messages: Belongs to the serpin family.

13616:ERBB2
gene id: 13616:ERBB2
uniprot id: A0A5F8GRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

13616:OTP
gene id: 13616:OTP
uniprot id: F6X3W5
names: Subcellular Location Annotation
messages: Nucleus

13616:GHITM
gene id: 13616:GHITM
uniprot id: F6S7G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

13616:RPLP0
gene id: 13616:RPLP0
uniprot id: F7B9X0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

13616:GALR1
gene id: 13616:GALR1
uniprot id: F6YFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:YWHAZ
gene id: 13616:YWHAZ
uniprot id: F7BS95
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:LOC100031017
gene id: 13616:LOC100031017
uniprot id: F6QJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

13616:TNP1
gene id: 13616:TNP1
uniprot id: F6ZI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus

13616:monDomV1R1215
gene id: 13616:monDomV1R1215
uniprot id: A0A5F8HKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CDK5RAP2
gene id: 13616:CDK5RAP2
uniprot id: F7GLC9
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: centrosome

13616:GDF9
gene id: 13616:GDF9
uniprot id: A0A5F8H619
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

13616:STON1
gene id: 13616:STON1
uniprot id: A0A5F8G7H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

13616:SH3YL1
gene id: 13616:SH3YL1
uniprot id: A0A5F8H8M0
uniprot id: F6XJ09
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

13616:BNIP3
gene id: 13616:BNIP3
uniprot id: H9H7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

13616:PNRC1
gene id: 13616:PNRC1
uniprot id: F6Q6C4
names: Subcellular Location Annotation
messages: Nucleus

13616:ZFYVE16
gene id: 13616:ZFYVE16
uniprot id: F6SG91
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

13616:JPT1
gene id: 13616:JPT1
uniprot id: A0A5F8GUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

13616:VN2R616
gene id: 13616:VN2R616
uniprot id: F7D5Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TSPAN9
gene id: 13616:TSPAN9
uniprot id: F6PRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:CELF1
gene id: 13616:CELF1
uniprot id: F6VPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100027633
gene id: 13616:LOC100027633
uniprot id: F6Z758
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

13616:APOA4
gene id: 13616:APOA4
uniprot id: F6TDB8
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

13616:LOC100017544
gene id: 13616:LOC100017544
uniprot id: A0A5F8G7L7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:NECAP2
gene id: 13616:NECAP2
uniprot id: F6PIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

13616:MBP
gene id: 13616:MBP
uniprot id: A0A5F8GHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

13616:TMBIM6
gene id: 13616:TMBIM6
uniprot id: F6TEK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

13616:CPLX2
gene id: 13616:CPLX2
uniprot id: A0A5F8GFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:YKT6
gene id: 13616:YKT6
uniprot id: A0A5F8H0W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

13616:ST3GAL6
gene id: 13616:ST3GAL6
uniprot id: F7G310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:GAL
gene id: 13616:GAL
uniprot id: F6SIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

13616:LOC100025087
gene id: 13616:LOC100025087
uniprot id: F6SVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PDE9A
gene id: 13616:PDE9A
uniprot id: F7FKQ2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:UBE2A
gene id: 13616:UBE2A
uniprot id: F6SAT6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:SERPINB2
gene id: 13616:SERPINB2
uniprot id: F7CGR3
names: Similarity
messages: Belongs to the serpin family.

13616:VGLL4
gene id: 13616:VGLL4
uniprot id: A0A5F8GE78
uniprot id: A0A5F8GG28
uniprot id: A0A5F8H2D1
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

13616:FASN
gene id: 13616:FASN
uniprot id: F7GKK4
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

13616:PPIL3
gene id: 13616:PPIL3
uniprot id: F7BX89
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:CDK10
gene id: 13616:CDK10
uniprot id: F7C8L6
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC107649133
gene id: 13616:LOC107649133
uniprot id: A0A5F8H3N1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

13616:DYM
gene id: 13616:DYM
uniprot id: F7C8I3
names: Similarity
messages: Belongs to the dymeclin family.

13616:CRTC1
gene id: 13616:CRTC1
uniprot id: A0A5F8GMY9
uniprot id: A0A5F8HFZ2
uniprot id: F7C6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

13616:KRT35
gene id: 13616:KRT35
uniprot id: F7ERN9
names: Similarity
messages: Belongs to the intermediate filament family.

13616:SHQ1
gene id: 13616:SHQ1
uniprot id: F7FH73
names: Similarity
messages: Belongs to the SHQ1 family.

13616:MRPS33
gene id: 13616:MRPS33
uniprot id: F6VE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

13616:PYCR2
gene id: 13616:PYCR2
uniprot id: F6WFB0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

13616:TENM2
gene id: 13616:TENM2
uniprot id: A0A5F8GJU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ADSS2
gene id: 13616:ADSS2
uniprot id: A0A5F8G4H9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

13616:POP4
gene id: 13616:POP4
uniprot id: K7DZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

13616:LEPROT
gene id: 13616:LEPROT
uniprot id: A0A5F8GNU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

13616:ETF1
gene id: 13616:ETF1
uniprot id: F7FU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

13616:HGFAC
gene id: 13616:HGFAC
uniprot id: F7CSQ9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:SZRD1
gene id: 13616:SZRD1
uniprot id: A0A5F8HC08
names: Similarity
messages: Belongs to the SZRD1 family.

13616:LOC100015945
gene id: 13616:LOC100015945
uniprot id: F7AJ61
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:INPP1
gene id: 13616:INPP1
uniprot id: F6XX24
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:LMX1B
gene id: 13616:LMX1B
uniprot id: F6TAA3
names: Subcellular Location Annotation
messages: Nucleus

13616:SLAIN2
gene id: 13616:SLAIN2
uniprot id: A0A5F8GXM4
uniprot id: F7EN68
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

13616:RPL10
gene id: 13616:RPL10
uniprot id: F6PU97
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

13616:RDH11
gene id: 13616:RDH11
uniprot id: F6US93
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:NIPBL
gene id: 13616:NIPBL
uniprot id: F7FKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

13616:LLPH
gene id: 13616:LLPH
uniprot id: K7E6A7
names: Similarity
messages: Belongs to the learning-associated protein family.

13616:PRKAR2B
gene id: 13616:PRKAR2B
uniprot id: F7ER73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

13616:DMRT1
gene id: 13616:DMRT1
uniprot id: F6Z0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:CPA3
gene id: 13616:CPA3
uniprot id: F6TIS2
names: Similarity
messages: Belongs to the peptidase M14 family.

13616:TVP23A
gene id: 13616:TVP23A
uniprot id: F7E7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

13616:LOC100013070
gene id: 13616:LOC100013070
uniprot id: F7C2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TADA1
gene id: 13616:TADA1
uniprot id: F7ANA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

13616:CPSF3
gene id: 13616:CPSF3
uniprot id: A0A5F8HDB0
uniprot id: F7D3K9
names: Subcellular Location Annotation
messages: Nucleus

13616:PSD
gene id: 13616:PSD
uniprot id: F7C6S5
names: Subcellular Location Annotation
messages: ruffle membrane

13616:MRPL22
gene id: 13616:MRPL22
uniprot id: F7CXK5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

13616:LOC100017512
gene id: 13616:LOC100017512
uniprot id: F6PZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CPPED1
gene id: 13616:CPPED1
uniprot id: A0A5F8GIR8
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

13616:DBT
gene id: 13616:DBT
uniprot id: A0A5F8GUX4
uniprot id: F7FPX4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

13616:GDPD3
gene id: 13616:GDPD3
uniprot id: F7EHS7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:PSMB3
gene id: 13616:PSMB3
uniprot id: F6S2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:LOC100012857
gene id: 13616:LOC100012857
uniprot id: A0A5F8G3Q8
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:RUSF1
gene id: 13616:RUSF1
uniprot id: F7A2S4
names: Similarity
messages: Belongs to the RUS1 family.

13616:LOC100018825
gene id: 13616:LOC100018825
uniprot id: F6PZU3
names: Similarity
messages: Belongs to the NLRP family.

13616:PPIL1
gene id: 13616:PPIL1
uniprot id: F7F8D1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:LOC100022370
gene id: 13616:LOC100022370
uniprot id: F6Q066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TM2D2
gene id: 13616:TM2D2
uniprot id: A0A5F8GGJ8
names: Subcellular Location Annotation
messages: Membrane

13616:HEATR5B
gene id: 13616:HEATR5B
uniprot id: A0A5F8H7P6
names: Similarity
messages: Belongs to the HEATR5 family.

13616:T2R40
gene id: 13616:T2R40
uniprot id: Q2AB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:LOC100027842
gene id: 13616:LOC100027842
uniprot id: A0A5F8GMJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:PRKAB1
gene id: 13616:PRKAB1
uniprot id: F6TML6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

13616:MAGI3
gene id: 13616:MAGI3
uniprot id: F7AV49
names: Subcellular Location Annotation
messages: Membrane

13616:POU3F1
gene id: 13616:POU3F1
uniprot id: F7FHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

13616:MTFR1L
gene id: 13616:MTFR1L
uniprot id: F6VAA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

13616:SEMA3A
gene id: 13616:SEMA3A
uniprot id: F6Q9V8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:AKR1A1
gene id: 13616:AKR1A1
uniprot id: F7GDV9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

13616:RAD21
gene id: 13616:RAD21
uniprot id: F6UVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

13616:OAZ1
gene id: 13616:OAZ1
uniprot id: F6TQ50
names: Similarity
messages: Belongs to the ODC antizyme family.

13616:LOC100018962
gene id: 13616:LOC100018962
uniprot id: F6V6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CFAP97D1
gene id: 13616:CFAP97D1
uniprot id: A0A5F8HE01
names: Similarity
messages: Belongs to the CFAP97 family.

13616:CNKSR3
gene id: 13616:CNKSR3
uniprot id: F7EKR3
names: Similarity
messages: Belongs to the CNKSR family.

13616:GEM
gene id: 13616:GEM
uniprot id: F7B0E6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

13616:CBFA2T2
gene id: 13616:CBFA2T2
uniprot id: F6Q219
names: Similarity
messages: Belongs to the CBFA2T family.

13616:NME9
gene id: 13616:NME9
uniprot id: F7FRS4
names: Similarity
messages: Belongs to the NDK family.

13616:S100A1
gene id: 13616:S100A1
uniprot id: F6VYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

13616:VWC2L
gene id: 13616:VWC2L
uniprot id: F7FEN3
names: Subcellular Location Annotation
messages: Synapse

13616:ABI3
gene id: 13616:ABI3
uniprot id: F7GGF8
names: Similarity
messages: Belongs to the ABI family.

13616:SEC31B
gene id: 13616:SEC31B
uniprot id: A0A5F8GUS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

13616:LRRC8E
gene id: 13616:LRRC8E
uniprot id: F7CGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:TMEM182
gene id: 13616:TMEM182
uniprot id: F7DZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

13616:CNOT3
gene id: 13616:CNOT3
uniprot id: A0A5F8HAG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

13616:MLF2
gene id: 13616:MLF2
uniprot id: F7FF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

13616:CDX1
gene id: 13616:CDX1
uniprot id: F6XTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

13616:CADM1
gene id: 13616:CADM1
uniprot id: A0A5F8G7W2
uniprot id: A0A5F8GK08
uniprot id: A0A5F8HCB9
uniprot id: A0A5F8HE77
uniprot id: A0A5F8HFD4
uniprot id: F6W9D2
names: Similarity
messages: Belongs to the nectin family.

13616:CHURC1
gene id: 13616:CHURC1
uniprot id: A0A5F8HCP8
names: Similarity
messages: Belongs to the Churchill family.

13616:MAP4K1
gene id: 13616:MAP4K1
uniprot id: F6YWC5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

13616:LOC100010723
gene id: 13616:LOC100010723
uniprot id: A0A5F8H0D4
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

13616:RAB21
gene id: 13616:RAB21
uniprot id: F7BE89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

13616:SOD2
gene id: 13616:SOD2
uniprot id: F7GJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

13616:ZDHHC14
gene id: 13616:ZDHHC14
uniprot id: F7D678
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:RIPOR1
gene id: 13616:RIPOR1
uniprot id: F6TL03
names: Similarity
messages: Belongs to the RIPOR family.

13616:LOC100032604
gene id: 13616:LOC100032604
uniprot id: K7E5P0
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:LOC100028935
gene id: 13616:LOC100028935
uniprot id: F7AWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MS4A1
gene id: 13616:MS4A1
uniprot id: F7G7B8
names: Similarity
messages: Belongs to the MS4A family.

13616:FERMT2
gene id: 13616:FERMT2
uniprot id: F7BNK8
names: Similarity
messages: Belongs to the kindlin family.

13616:EPCAM
gene id: 13616:EPCAM
uniprot id: F7GI03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PROS1
gene id: 13616:PROS1
uniprot id: F6UL60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RBM8A
gene id: 13616:RBM8A
uniprot id: A0A5F8HHR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

13616:ENAH
gene id: 13616:ENAH
uniprot id: F7FCN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

13616:DCLRE1C
gene id: 13616:DCLRE1C
uniprot id: A0A5F8G287
uniprot id: A0A5F8G808
uniprot id: F6VMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

13616:PPIP5K2
gene id: 13616:PPIP5K2
uniprot id: F6RZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

13616:SPACA4
gene id: 13616:SPACA4
uniprot id: F7C1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

13616:CDH6
gene id: 13616:CDH6
uniprot id: F6Y191
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:MILL-like
gene id: 13616:MILL-like
uniprot id: A0A5F8GUB8
uniprot id: D7URV5
names: Similarity
messages: Belongs to the MHC class I family.

13616:CCNF
gene id: 13616:CCNF
uniprot id: F6Z4F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus
messages: centriole
messages: perinuclear region

13616:FOXF2
gene id: 13616:FOXF2
uniprot id: F7FGY5
names: Subcellular Location Annotation
messages: Nucleus

13616:MAPRE1
gene id: 13616:MAPRE1
uniprot id: F6RY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

13616:CAB39
gene id: 13616:CAB39
uniprot id: F7D4X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

13616:LIPG
gene id: 13616:LIPG
uniprot id: F7G148
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:CD79A
gene id: 13616:CD79A
uniprot id: D7F467
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100027288
gene id: 13616:LOC100027288
uniprot id: F7CHK3
names: Subcellular Location Annotation
messages: Membrane

13616:PRDX6
gene id: 13616:PRDX6
uniprot id: F7CMG3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

13616:MRS2
gene id: 13616:MRS2
uniprot id: F6QWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

13616:SLC35A1
gene id: 13616:SLC35A1
uniprot id: F6PUN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:STYXL2
gene id: 13616:STYXL2
uniprot id: F7B956
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

13616:HOXA10
gene id: 13616:HOXA10
uniprot id: F6URM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:RTN4IP1
gene id: 13616:RTN4IP1
uniprot id: K7E2Y8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

13616:GBF1
gene id: 13616:GBF1
uniprot id: F6SPN8
names: Subcellular Location Annotation
messages: Golgi apparatus

13616:ARRDC4
gene id: 13616:ARRDC4
uniprot id: A0A5F8H4Y1
names: Similarity
messages: Belongs to the arrestin family.

13616:DCTN1
gene id: 13616:DCTN1
uniprot id: A0A5F8GV11
uniprot id: F7EQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

13616:SLC25A18
gene id: 13616:SLC25A18
uniprot id: F7CUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:EGFLAM
gene id: 13616:EGFLAM
uniprot id: F7FWY4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:C3H18orf32
gene id: 13616:C3H18orf32
uniprot id: F7C7W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

13616:TAS2R1
gene id: 13616:TAS2R1
uniprot id: Q2ABA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:ID4
gene id: 13616:ID4
uniprot id: F6WJF0
names: Subcellular Location Annotation
messages: Nucleus

13616:MAP7
gene id: 13616:MAP7
uniprot id: A0A5F8H4Z3
uniprot id: A0A5F8HE63
names: Similarity
messages: Belongs to the MAP7 family.

13616:LOC100018981
gene id: 13616:LOC100018981
uniprot id: F6U150
names: Subcellular Location Annotation
messages: Nucleus

13616:VIPR1
gene id: 13616:VIPR1
uniprot id: F7BIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

13616:LTN1
gene id: 13616:LTN1
uniprot id: F6RK02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

13616:DPP4
gene id: 13616:DPP4
uniprot id: F7D0P2
uniprot id: K7DYU6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

13616:NR2E1
gene id: 13616:NR2E1
uniprot id: F7AL53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:TMEM50A
gene id: 13616:TMEM50A
uniprot id: A0A5F8HDH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

13616:LOC100019084
gene id: 13616:LOC100019084
uniprot id: F7FQM8
names: Subcellular Location Annotation
messages: Membrane

13616:ARRDC3
gene id: 13616:ARRDC3
uniprot id: F6YRB9
names: Similarity
messages: Belongs to the arrestin family.

13616:SLC6A5
gene id: 13616:SLC6A5
uniprot id: F7B0M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:CUL2
gene id: 13616:CUL2
uniprot id: A0A5F8HH30
uniprot id: F6RG61
names: Similarity
messages: Belongs to the cullin family.

13616:LOC100020922
gene id: 13616:LOC100020922
uniprot id: F6STH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:LOC100019929
gene id: 13616:LOC100019929
uniprot id: F6Z4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KCNK15
gene id: 13616:KCNK15
uniprot id: F7FY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:ARL11
gene id: 13616:ARL11
uniprot id: F6X0M1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:POU4F2
gene id: 13616:POU4F2
uniprot id: F6X542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

13616:NDEL1
gene id: 13616:NDEL1
uniprot id: F7CL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

13616:LOC100028751
gene id: 13616:LOC100028751
uniprot id: F7FSM7
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100025235
gene id: 13616:LOC100025235
uniprot id: F7GFJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:FBXO34
gene id: 13616:FBXO34
uniprot id: A0A5F8G972
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

13616:YPEL2
gene id: 13616:YPEL2
uniprot id: F7AS66
names: Similarity
messages: Belongs to the yippee family.

13616:WNK4
gene id: 13616:WNK4
uniprot id: F7FUV6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

13616:ABCG4
gene id: 13616:ABCG4
uniprot id: F7D9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:CROT
gene id: 13616:CROT
uniprot id: A0A5F8G7Z6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:LOC100011471
gene id: 13616:LOC100011471
uniprot id: F7C8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:WFIKKN1
gene id: 13616:WFIKKN1
uniprot id: F7D2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

13616:GSKIP
gene id: 13616:GSKIP
uniprot id: A0A5F8H934
names: Similarity
messages: Belongs to the GSKIP family.

13616:PTH1R
gene id: 13616:PTH1R
uniprot id: F6R731
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

13616:ADAMTS5
gene id: 13616:ADAMTS5
uniprot id: F6RJX5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:MEPCE
gene id: 13616:MEPCE
uniprot id: F6R6T5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:CIRBP
gene id: 13616:CIRBP
uniprot id: F7E6M5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

13616:DCP2
gene id: 13616:DCP2
uniprot id: F7FEL1
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

13616:ATG4C
gene id: 13616:ATG4C
uniprot id: A0A5F8HLB7
uniprot id: F7FIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

13616:DTD2
gene id: 13616:DTD2
uniprot id: A0A5F8GMX9
names: Similarity
messages: Belongs to the DTD family.

13616:BHMT2
gene id: 13616:BHMT2
uniprot id: A0A5F8G3W4
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

13616:CALHM5
gene id: 13616:CALHM5
uniprot id: F6Z8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:LOC100020693
gene id: 13616:LOC100020693
uniprot id: F6VGW0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:MCUB
gene id: 13616:MCUB
uniprot id: A0A5F8G4G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ITGB6
gene id: 13616:ITGB6
uniprot id: F6ZCH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

13616:UGGT2
gene id: 13616:UGGT2
uniprot id: F7CUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

13616:RPP14
gene id: 13616:RPP14
uniprot id: F7GLS4
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

13616:LOC100023663
gene id: 13616:LOC100023663
uniprot id: F6WGJ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:GORASP1
gene id: 13616:GORASP1
uniprot id: K7DZF6
names: Similarity
messages: Belongs to the GORASP family.

13616:GSR
gene id: 13616:GSR
uniprot id: F7CP75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

13616:YAE1
gene id: 13616:YAE1
uniprot id: A0A5F8HI68
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:CD53
gene id: 13616:CD53
uniprot id: A0A5F8HE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:LOC100032615
gene id: 13616:LOC100032615
uniprot id: F6X4V0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

13616:ERMN
gene id: 13616:ERMN
uniprot id: A0A5F8HDM9
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

13616:PNPLA6
gene id: 13616:PNPLA6
uniprot id: F7FHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CNOT6L
gene id: 13616:CNOT6L
uniprot id: A0A5F8HK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

13616:NR0B2
gene id: 13616:NR0B2
uniprot id: F7BH57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

13616:CENPC
gene id: 13616:CENPC
uniprot id: F7AN85
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

13616:URAD
gene id: 13616:URAD
uniprot id: A0A5F8G3T1
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

13616:GDF10
gene id: 13616:GDF10
uniprot id: F6UZ74
names: Similarity
messages: Belongs to the TGF-beta family.

13616:MODO-UB
gene id: 13616:MODO-UB
uniprot id: Q5W5U6
names: Similarity
messages: Belongs to the MHC class I family.

13616:SLX4
gene id: 13616:SLX4
uniprot id: F7AT45
names: Similarity
messages: Belongs to the SLX4 family.

13616:LOC100016236
gene id: 13616:LOC100016236
uniprot id: F6RQ67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:HNF4G
gene id: 13616:HNF4G
uniprot id: F6PGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:PDHA1
gene id: 13616:PDHA1
uniprot id: A0A5F8GC60
uniprot id: F7AF77
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

13616:LOC100022185
gene id: 13616:LOC100022185
uniprot id: F7BVK1
names: Subcellular Location Annotation
messages: Nucleus

13616:N6AMT1
gene id: 13616:N6AMT1
uniprot id: F6RJZ3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

13616:CAV1
gene id: 13616:CAV1
uniprot id: F7FDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

13616:TOP2B
gene id: 13616:TOP2B
uniprot id: F7D0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

13616:PEX1
gene id: 13616:PEX1
uniprot id: F7G7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

13616:LOC100011551
gene id: 13616:LOC100011551
uniprot id: K7DZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

13616:GPATCH11
gene id: 13616:GPATCH11
uniprot id: F6T6L9
names: Similarity
messages: Belongs to the GPATCH11 family.

13616:LOC100027666
gene id: 13616:LOC100027666
uniprot id: F7CMU3
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

13616:PSME3
gene id: 13616:PSME3
uniprot id: A0A5F8H5U2
names: Similarity
messages: Belongs to the PA28 family.

13616:ITGB8
gene id: 13616:ITGB8
uniprot id: F7FJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

13616:NUP85
gene id: 13616:NUP85
uniprot id: F6VWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

13616:ATP6V1A
gene id: 13616:ATP6V1A
uniprot id: F7CCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

13616:PUS10
gene id: 13616:PUS10
uniprot id: F7G3Q0
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

13616:EPN2
gene id: 13616:EPN2
uniprot id: A0A5F8HKM5
uniprot id: F7F5A9
names: Similarity
messages: Belongs to the epsin family.

13616:LOC100018127
gene id: 13616:LOC100018127
uniprot id: A0A5F8G6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DDX59
gene id: 13616:DDX59
uniprot id: A0A5F8GYP3
uniprot id: A0A5F8HA09
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

13616:DZIP1
gene id: 13616:DZIP1
uniprot id: A0A5F8H0T6
uniprot id: F7DWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

13616:PMS2
gene id: 13616:PMS2
uniprot id: F7E4Y3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

13616:TBP
gene id: 13616:TBP
uniprot id: F7CFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

13616:RRP1B
gene id: 13616:RRP1B
uniprot id: F6W0J2
names: Similarity
messages: Belongs to the RRP1 family.

13616:LRP12
gene id: 13616:LRP12
uniprot id: A0A5F8G8W0
uniprot id: F7FVQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:JPT2
gene id: 13616:JPT2
uniprot id: F7D6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

13616:TM4SF4
gene id: 13616:TM4SF4
uniprot id: F6T2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:CDC42SE2
gene id: 13616:CDC42SE2
uniprot id: F6ZHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

13616:GPR107
gene id: 13616:GPR107
uniprot id: F6UFL2
names: Subcellular Location Annotation
messages: Membrane

13616:INTS11
gene id: 13616:INTS11
uniprot id: F7CAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

13616:ACTR6
gene id: 13616:ACTR6
uniprot id: A0A5F8G3U6
uniprot id: A0A5F8GWN0
uniprot id: F7F5S1
names: Similarity
messages: Belongs to the actin family.

13616:HS3ST2
gene id: 13616:HS3ST2
uniprot id: A0A5F8GST9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:SOX3
gene id: 13616:SOX3
uniprot id: F6SCS3
names: Subcellular Location Annotation
messages: Nucleus

13616:TSPAN12
gene id: 13616:TSPAN12
uniprot id: F6WFC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:LOC100028625
gene id: 13616:LOC100028625
uniprot id: F7G428
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

13616:NSMCE4A
gene id: 13616:NSMCE4A
uniprot id: F7BUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

13616:CFAP300
gene id: 13616:CFAP300
uniprot id: F6X4G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

13616:KEAP1
gene id: 13616:KEAP1
uniprot id: F6QE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

13616:BTNL9
gene id: 13616:BTNL9
uniprot id: A0A5F8G9S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

13616:SLC15A3
gene id: 13616:SLC15A3
uniprot id: H9H673
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

13616:CD74
gene id: 13616:CD74
uniprot id: K7E537
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VN2R527
gene id: 13616:VN2R527
uniprot id: F7EB70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PRTFDC1
gene id: 13616:PRTFDC1
uniprot id: A0A5F8H6J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

13616:LOC100013511
gene id: 13616:LOC100013511
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:PJVK
gene id: 13616:PJVK
uniprot id: F7EF78
names: Similarity
messages: Belongs to the gasdermin family.

13616:USP13
gene id: 13616:USP13
uniprot id: F7G3T7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:SS18
gene id: 13616:SS18
uniprot id: A0A5F8H2A1
uniprot id: F7FSI0
names: Similarity
messages: Belongs to the SS18 family.

13616:INKA1
gene id: 13616:INKA1
uniprot id: F6PN08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

13616:FTO
gene id: 13616:FTO
uniprot id: A0A5F8GF52
uniprot id: A0A5F8GKL6
uniprot id: A0A5F8HA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.
messages: Cytoplasm
messages: Nucleus speckle

13616:PGLYRP1
gene id: 13616:PGLYRP1
uniprot id: F7FSD2
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

13616:LOC103106484
gene id: 13616:LOC103106484
uniprot id: A0A5F8GAI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

13616:PTGR1
gene id: 13616:PTGR1
uniprot id: F6U6I4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

13616:EMC2
gene id: 13616:EMC2
uniprot id: F7A6D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

13616:GLO1
gene id: 13616:GLO1
uniprot id: F7ECV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

13616:SENP7
gene id: 13616:SENP7
uniprot id: F6V2A6
names: Similarity
messages: Belongs to the peptidase C48 family.

13616:TGFBR2
gene id: 13616:TGFBR2
uniprot id: F7CFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

13616:PRDM1
gene id: 13616:PRDM1
uniprot id: F6ZWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

13616:PKM
gene id: 13616:PKM
uniprot id: A0A5F8GJZ6
uniprot id: F6WGC5
names: Similarity
messages: Belongs to the pyruvate kinase family.

13616:ZDHHC21
gene id: 13616:ZDHHC21
uniprot id: F7CG33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:MPP7
gene id: 13616:MPP7
uniprot id: F7DJR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

13616:GAPDHS
gene id: 13616:GAPDHS
uniprot id: F6VBR8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

13616:MDFI
gene id: 13616:MDFI
uniprot id: A0A5F8GQ01
names: Similarity
messages: Belongs to the MDFI family.

13616:OSTC
gene id: 13616:OSTC
uniprot id: A0A5F8H7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

13616:ACAA1
gene id: 13616:ACAA1
uniprot id: F6XXA9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:SNRPE
gene id: 13616:SNRPE
uniprot id: K7DZR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

13616:KDM5A
gene id: 13616:KDM5A
uniprot id: A0A5F8HAH0
uniprot id: F6QU82
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

13616:SH3GL2
gene id: 13616:SH3GL2
uniprot id: F7BZ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

13616:MRPS18C
gene id: 13616:MRPS18C
uniprot id: F6Z9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

13616:TMEM94
gene id: 13616:TMEM94
uniprot id: F6YYK0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100009811
gene id: 13616:LOC100009811
uniprot id: A0A5F8HI45
names: Similarity
messages: Belongs to the CLCR family.

13616:SNTA1
gene id: 13616:SNTA1
uniprot id: F6PP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

13616:ALDH1L2
gene id: 13616:ALDH1L2
uniprot id: F6UZX8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

13616:KRT32
gene id: 13616:KRT32
uniprot id: F6SRI1
names: Similarity
messages: Belongs to the intermediate filament family.

13616:PPP2R5C
gene id: 13616:PPP2R5C
uniprot id: F7D9Z3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:GALNT1
gene id: 13616:GALNT1
uniprot id: F6TU35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:SOX14
gene id: 13616:SOX14
uniprot id: F6XNT3
names: Subcellular Location Annotation
messages: Nucleus

13616:ATP8B1
gene id: 13616:ATP8B1
uniprot id: F7AQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:TNK2
gene id: 13616:TNK2
uniprot id: F6XU33
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

13616:ITPRIPL2
gene id: 13616:ITPRIPL2
uniprot id: F6RPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

13616:HSP90AA1
gene id: 13616:HSP90AA1
uniprot id: F6ZJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

13616:STIM1
gene id: 13616:STIM1
uniprot id: A0A5F8GHF9
names: Subcellular Location Annotation
messages: Membrane

13616:ALKBH5
gene id: 13616:ALKBH5
uniprot id: F6XQJ4
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

13616:CASTOR2
gene id: 13616:CASTOR2
uniprot id: F6PTR3
names: Similarity
messages: Belongs to the GATS family.

13616:MALSU1
gene id: 13616:MALSU1
uniprot id: F6ZF75
names: Similarity
messages: Belongs to the Iojap/RsfS family.

13616:NDUFB6
gene id: 13616:NDUFB6
uniprot id: F6QJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:RPL4
gene id: 13616:RPL4
uniprot id: F6QS92
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

13616:MCRIP2
gene id: 13616:MCRIP2
uniprot id: F7D1U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

13616:LOC100017736
gene id: 13616:LOC100017736
uniprot id: F6TI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

13616:PLPP1
gene id: 13616:PLPP1
uniprot id: A0A5F8GBD0
uniprot id: F6VUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:CNOT9
gene id: 13616:CNOT9
uniprot id: F6T3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

13616:ALAS1
gene id: 13616:ALAS1
uniprot id: F7GEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

13616:ZFPM2
gene id: 13616:ZFPM2
uniprot id: F6YLF5
names: Subcellular Location Annotation
messages: Nucleus

13616:ABITRAM
gene id: 13616:ABITRAM
uniprot id: F6PLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

13616:MODO-UK
gene id: 13616:MODO-UK
uniprot id: A0A5F8H5G0
uniprot id: C6ZIV1
names: Similarity
messages: Belongs to the MHC class I family.

13616:OAZ2
gene id: 13616:OAZ2
uniprot id: A0A5F8G915
names: Similarity
messages: Belongs to the ODC antizyme family.

13616:SYNGR3
gene id: 13616:SYNGR3
uniprot id: F7GIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

13616:VPS25
gene id: 13616:VPS25
uniprot id: F7FUU3
names: Similarity
messages: Belongs to the VPS25 family.

13616:CEP19
gene id: 13616:CEP19
uniprot id: F7CUD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

13616:CHRM3
gene id: 13616:CHRM3
uniprot id: F6XBA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

13616:CAPN7
gene id: 13616:CAPN7
uniprot id: F7ERL1
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:MYO16
gene id: 13616:MYO16
uniprot id: F7AT26
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:MRPS14
gene id: 13616:MRPS14
uniprot id: F6SVT1
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

13616:POLR3D
gene id: 13616:POLR3D
uniprot id: F7FN65
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103098551
gene id: 13616:LOC103098551
uniprot id: F7E6F9
names: Subcellular Location Annotation
messages: Membrane

13616:MYF6
gene id: 13616:MYF6
uniprot id: A0A5F8GZT0
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100016983
gene id: 13616:LOC100016983
uniprot id: F7F6C6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

13616:LOC100029940
gene id: 13616:LOC100029940
uniprot id: F7FSK6
names: Subcellular Location Annotation
messages: Membrane

13616:KLHL3
gene id: 13616:KLHL3
uniprot id: A0A5F8HB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

13616:VN2R648
gene id: 13616:VN2R648
uniprot id: F6WGY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100024568
gene id: 13616:LOC100024568
uniprot id: F6PJ15
names: Similarity
messages: Belongs to the serpin family.

13616:monDomV1R1208
gene id: 13616:monDomV1R1208
uniprot id: A0A5F8G944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CRYBB1
gene id: 13616:CRYBB1
uniprot id: F7G7F5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:TSPAN11
gene id: 13616:TSPAN11
uniprot id: F6PSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:CAND2
gene id: 13616:CAND2
uniprot id: F7G2I7
names: Similarity
messages: Belongs to the CAND family.

13616:EPHX1
gene id: 13616:EPHX1
uniprot id: F6SN50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:PALM3
gene id: 13616:PALM3
uniprot id: F7G546
names: Similarity
messages: Belongs to the paralemmin family.

13616:DCTD
gene id: 13616:DCTD
uniprot id: F6UWJ2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

13616:LOC100017340
gene id: 13616:LOC100017340
uniprot id: F6TBR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNRPB
gene id: 13616:SNRPB
uniprot id: Q9TU66
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). Component of the U1 snRNP (By similarity). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (By similarity). Component of the minor spliceosome, which splices U12-type introns (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (By similarity). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction leads to it…
messages: Methylated by PRMT5 (By similarity). Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
messages: cytosol

13616:DHODH
gene id: 13616:DHODH
uniprot id: A0A5F8H9U5
uniprot id: F7BVX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

13616:LOC100019591
gene id: 13616:LOC100019591
uniprot id: F6Z4Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100028235
gene id: 13616:LOC100028235
uniprot id: A0A5F8HED8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:WLS
gene id: 13616:WLS
uniprot id: F6T8H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

13616:RIBC2
gene id: 13616:RIBC2
uniprot id: F7FQY6
names: Similarity
messages: Belongs to the RIB43A family.

13616:WAS
gene id: 13616:WAS
uniprot id: F6SA08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Nucleus
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

13616:MCM7
gene id: 13616:MCM7
uniprot id: F6UBM6
uniprot id: K7E231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:TTC9
gene id: 13616:TTC9
uniprot id: F6RD84
names: Similarity
messages: Belongs to the TTC9 family.

13616:TMEM258
gene id: 13616:TMEM258
uniprot id: A0A5F8H1I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:AMN
gene id: 13616:AMN
uniprot id: F7DTU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:FGF12
gene id: 13616:FGF12
uniprot id: F7ELZ5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:SYNJ1
gene id: 13616:SYNJ1
uniprot id: A0A5F8GRI3
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

13616:LARS2
gene id: 13616:LARS2
uniprot id: A0A5F8GDF7
uniprot id: F6WJ64
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:MAP2
gene id: 13616:MAP2
uniprot id: A0A5F8GUW9
names: Subcellular Location Annotation
messages: cytoskeleton

13616:REV3L
gene id: 13616:REV3L
uniprot id: A0A5F8GU36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

13616:SRFBP1
gene id: 13616:SRFBP1
uniprot id: F6QFG0
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

13616:ST6GALNAC6
gene id: 13616:ST6GALNAC6
uniprot id: A0A5F8HDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:YJU2B
gene id: 13616:YJU2B
uniprot id: F7G340
names: Similarity
messages: Belongs to the CWC16 family.

13616:GMNN
gene id: 13616:GMNN
uniprot id: F7GE78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

13616:SCMH1
gene id: 13616:SCMH1
uniprot id: F6WVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

13616:ACER3
gene id: 13616:ACER3
uniprot id: A0A5F8H809
uniprot id: F7A1V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:EEF1AKMT1
gene id: 13616:EEF1AKMT1
uniprot id: F6ZYG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

13616:NARF
gene id: 13616:NARF
uniprot id: F6RZA8
names: Similarity
messages: Belongs to the NARF family.

13616:LOC100618776
gene id: 13616:LOC100618776
uniprot id: A0A5F8GPS1
names: Similarity
messages: Belongs to the globin family.

13616:ACTL10
gene id: 13616:ACTL10
uniprot id: F6Q4H1
names: Similarity
messages: Belongs to the actin family.

13616:ORC4
gene id: 13616:ORC4
uniprot id: F7DDI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

13616:NOTUM
gene id: 13616:NOTUM
uniprot id: F6WU00
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

13616:ATP6V1H
gene id: 13616:ATP6V1H
uniprot id: A0A5F8HGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:OTUD7B
gene id: 13616:OTUD7B
uniprot id: F7AE38
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:UTP3
gene id: 13616:UTP3
uniprot id: F7FNE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

13616:KIFC2
gene id: 13616:KIFC2
uniprot id: F7EP41
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:TRPM7
gene id: 13616:TRPM7
uniprot id: F7GDX3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

13616:AK1
gene id: 13616:AK1
uniprot id: A0A5F8G8W5
uniprot id: A0A5F8HBA4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

13616:monDomV1R1267
gene id: 13616:monDomV1R1267
uniprot id: F6V7E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ERLIN2
gene id: 13616:ERLIN2
uniprot id: F7FJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

13616:CTU2
gene id: 13616:CTU2
uniprot id: F7B1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

13616:AOX4
gene id: 13616:AOX4
uniprot id: M1ZMS0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

13616:CNIH4
gene id: 13616:CNIH4
uniprot id: F7DP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

13616:DGKH
gene id: 13616:DGKH
uniprot id: F6UU82
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

13616:TMEM254
gene id: 13616:TMEM254
uniprot id: F7D4D9
names: Subcellular Location Annotation
messages: Membrane

13616:FOXB2
gene id: 13616:FOXB2
uniprot id: F7DZ45
names: Subcellular Location Annotation
messages: Nucleus

13616:GPSM2
gene id: 13616:GPSM2
uniprot id: F7CVY1
names: Similarity
messages: Belongs to the GPSM family.

13616:LOC103101138
gene id: 13616:LOC103101138
uniprot id: A0A5F8HH60
uniprot id: K7E274
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

13616:BRINP2
gene id: 13616:BRINP2
uniprot id: F6QEE5
names: Similarity
messages: Belongs to the BRINP family.

13616:LAMB1
gene id: 13616:LAMB1
uniprot id: F7A5M5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

13616:LOC100030436
gene id: 13616:LOC100030436
uniprot id: F7BRF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FGF18
gene id: 13616:FGF18
uniprot id: A0A5F8GTF4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:BABAM2
gene id: 13616:BABAM2
uniprot id: A0A5F8GMC4
uniprot id: F6ZV60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

13616:GJA1
gene id: 13616:GJA1
uniprot id: F7E4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:monDomV1R1242
gene id: 13616:monDomV1R1242
uniprot id: F7GLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KCNS2
gene id: 13616:KCNS2
uniprot id: F7E3Z0
names: Subcellular Location Annotation
messages: Membrane

13616:NPTX1
gene id: 13616:NPTX1
uniprot id: A0A5F8HJF5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DYNLL1
gene id: 13616:DYNLL1
uniprot id: F6WUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

13616:SEC61B
gene id: 13616:SEC61B
uniprot id: F6VXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

13616:CHPF2
gene id: 13616:CHPF2
uniprot id: F6SCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:RFLB
gene id: 13616:RFLB
uniprot id: A0A5F8G4Z5
uniprot id: B1AAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

13616:LOC100012360
gene id: 13616:LOC100012360
uniprot id: F6T389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:LCNL1
gene id: 13616:LCNL1
uniprot id: K7E5E8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:BANF1
gene id: 13616:BANF1
uniprot id: F7GCP3
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024733
gene id: 13616:LOC100024733
uniprot id: A0A5F8H4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPS16
gene id: 13616:RPS16
uniprot id: F7C3L8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

13616:LOC100618683
gene id: 13616:LOC100618683
uniprot id: F7A6Z3
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100021023
gene id: 13616:LOC100021023
uniprot id: F6RPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOX
gene id: 13616:LOX
uniprot id: F7F939
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

13616:EIF4A3
gene id: 13616:EIF4A3
uniprot id: F7GE48
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:RNF13
gene id: 13616:RNF13
uniprot id: F6T2X0
names: Subcellular Location Annotation
messages: Membrane

13616:NDUFA13
gene id: 13616:NDUFA13
uniprot id: F6X8Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

13616:LOC100027703
gene id: 13616:LOC100027703
uniprot id: A0A5F8HI21
uniprot id: F7DDL6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

13616:VN2R560
gene id: 13616:VN2R560
uniprot id: A0A5F8G747
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RND3
gene id: 13616:RND3
uniprot id: F6RYV4
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

13616:LOC100016275
gene id: 13616:LOC100016275
uniprot id: F6RQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:TYSND1
gene id: 13616:TYSND1
uniprot id: F7CEH3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

13616:BCLAF3
gene id: 13616:BCLAF3
uniprot id: A0A5F8GIB8
uniprot id: A0A5F8GMU8
uniprot id: A0A5F8GRQ6
uniprot id: A0A5F8H0A3
uniprot id: F7E4Z7
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

13616:PROX2
gene id: 13616:PROX2
uniprot id: F7BT12
names: Subcellular Location Annotation
messages: Nucleus

13616:CNN1
gene id: 13616:CNN1
uniprot id: F7FFG1
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

13616:ANXA3
gene id: 13616:ANXA3
uniprot id: A0A5F8H2F7
uniprot id: F6S7A7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:CDC42EP1
gene id: 13616:CDC42EP1
uniprot id: F6XMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

13616:TAS2R38
gene id: 13616:TAS2R38
uniprot id: Q2AB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:LOC103106173
gene id: 13616:LOC103106173
uniprot id: A0A5F8HAS6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:IRAK4
gene id: 13616:IRAK4
uniprot id: F7GD74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

13616:LEF1
gene id: 13616:LEF1
uniprot id: A0A5F8GT74
uniprot id: F6ZBJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

13616:PARPBP
gene id: 13616:PARPBP
uniprot id: A0A5F8G9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100019315
gene id: 13616:LOC100019315
uniprot id: F6YZ91
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

13616:TM7SF3
gene id: 13616:TM7SF3
uniprot id: F6YNC1
names: Subcellular Location Annotation
messages: Membrane

13616:DNAAF1
gene id: 13616:DNAAF1
uniprot id: F7ATT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
messages: cilium

13616:LOC100023213
gene id: 13616:LOC100023213
uniprot id: F6V2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SERPINE1
gene id: 13616:SERPINE1
uniprot id: F7C1N5
names: Similarity
messages: Belongs to the serpin family.

13616:GFRA3
gene id: 13616:GFRA3
uniprot id: F7CXX6
names: Similarity
messages: Belongs to the GDNFR family.

13616:SAMHD1
gene id: 13616:SAMHD1
uniprot id: F7CIF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

13616:PABIR3
gene id: 13616:PABIR3
uniprot id: A0A5F8GYJ8
uniprot id: A0A5F8H6G7
uniprot id: F7BW30
names: Similarity
messages: Belongs to the FAM122 family.

13616:LOC100017206
gene id: 13616:LOC100017206
uniprot id: F7GG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

13616:TJP3
gene id: 13616:TJP3
uniprot id: A0A5F8GRP3
uniprot id: F6WP06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:FEZ2
gene id: 13616:FEZ2
uniprot id: A0A5F8HGY6
uniprot id: F6TKQ2
names: Similarity
messages: Belongs to the zygin family.

13616:LOC100017675
gene id: 13616:LOC100017675
uniprot id: F6T3A4
names: Similarity
messages: Belongs to the multicopper oxidase family.

13616:CHAT
gene id: 13616:CHAT
uniprot id: F7ALU3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:RPS27
gene id: 13616:RPS27
uniprot id: F6SM23
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

13616:TMTC1
gene id: 13616:TMTC1
uniprot id: A0A5F8GKU3
uniprot id: F6UAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

13616:PRKAA2
gene id: 13616:PRKAA2
uniprot id: F7FPU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Nucleus

13616:SCAMP5
gene id: 13616:SCAMP5
uniprot id: A0A5F8GNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

13616:PRICKLE1
gene id: 13616:PRICKLE1
uniprot id: F7CAA2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

13616:LOC100021655
gene id: 13616:LOC100021655
uniprot id: F6PZL9
names: Subcellular Location Annotation
messages: Membrane

13616:CAPZA2
gene id: 13616:CAPZA2
uniprot id: Q2QL99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

13616:monDomV1R1259
gene id: 13616:monDomV1R1259
uniprot id: F6Z3R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POLR3A
gene id: 13616:POLR3A
uniprot id: F6ZEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

13616:RAB33A
gene id: 13616:RAB33A
uniprot id: F7D9I2
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

13616:LOC100024846
gene id: 13616:LOC100024846
uniprot id: F7GIH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KHDRBS3
gene id: 13616:KHDRBS3
uniprot id: F7ESF8
names: Similarity
messages: Belongs to the KHDRBS family.

13616:NT5DC2
gene id: 13616:NT5DC2
uniprot id: F6W363
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

13616:TMEM39A
gene id: 13616:TMEM39A
uniprot id: F7B771
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

13616:FBP1
gene id: 13616:FBP1
uniprot id: A0A5F8HJ19
names: Similarity
messages: Belongs to the FBPase class 1 family.

13616:LOC100028564
gene id: 13616:LOC100028564
uniprot id: F7AJW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

13616:KCNK3
gene id: 13616:KCNK3
uniprot id: F6ZSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:CAT
gene id: 13616:CAT
uniprot id: F6Y8K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

13616:FLOT1
gene id: 13616:FLOT1
uniprot id: F7F085
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Membrane
messages: caveola

13616:BACE2
gene id: 13616:BACE2
uniprot id: F6SNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane

13616:PPP4R3B
gene id: 13616:PPP4R3B
uniprot id: F6W0L9
names: Similarity
messages: Belongs to the SMEK family.

13616:RECQL5
gene id: 13616:RECQL5
uniprot id: F7GB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

13616:RNGTT
gene id: 13616:RNGTT
uniprot id: A0A5F8HKX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

13616:NAAA
gene id: 13616:NAAA
uniprot id: F6ZHY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

13616:RAMP1
gene id: 13616:RAMP1
uniprot id: A0A5F8H2K0
names: Similarity
messages: Belongs to the RAMP family.

13616:PIPOX
gene id: 13616:PIPOX
uniprot id: A0A5F8H7Q1
names: Similarity
messages: Belongs to the MSOX/MTOX family.

13616:LOC100617936
gene id: 13616:LOC100617936
uniprot id: A0A5F8GBB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:LOC100021232
gene id: 13616:LOC100021232
uniprot id: F7F6F9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

13616:LBR
gene id: 13616:LBR
uniprot id: F6TKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

13616:YJU2
gene id: 13616:YJU2
uniprot id: F6RPP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

13616:TRIM2
gene id: 13616:TRIM2
uniprot id: A0A5F8G5X1
names: Similarity
messages: Belongs to the TRIM/RBCC family.

13616:GABRB2
gene id: 13616:GABRB2
uniprot id: A0A5F8HCT3
uniprot id: F7EBG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:LOC100016012
gene id: 13616:LOC100016012
uniprot id: F7CIV5
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

13616:NOX4
gene id: 13616:NOX4
uniprot id: F6Z703
names: Subcellular Location Annotation
messages: Membrane

13616:NSMCE2
gene id: 13616:NSMCE2
uniprot id: K7E4G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

13616:SLC52A2
gene id: 13616:SLC52A2
uniprot id: A0A5F8HK45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

13616:HOMER1
gene id: 13616:HOMER1
uniprot id: A0A5F8G504
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

13616:VN2R514
gene id: 13616:VN2R514
uniprot id: F6PP39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PMEPA1
gene id: 13616:PMEPA1
uniprot id: F7EQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:LAMP3
gene id: 13616:LAMP3
uniprot id: A0A5F8H8Y0
uniprot id: F7GE18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

13616:RNF167
gene id: 13616:RNF167
uniprot id: F7D206
names: Subcellular Location Annotation
messages: Membrane

13616:MNX1
gene id: 13616:MNX1
uniprot id: F6XG12
names: Subcellular Location Annotation
messages: Nucleus

13616:MCM6
gene id: 13616:MCM6
uniprot id: F7ES17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

13616:LOC100024691
gene id: 13616:LOC100024691
uniprot id: F7D533
names: Similarity
messages: Belongs to the apolipoprotein L family.

13616:MTRF1
gene id: 13616:MTRF1
uniprot id: F7G763
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

13616:monDomV1R1251
gene id: 13616:monDomV1R1251
uniprot id: A0A5F8GZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CWF19L1
gene id: 13616:CWF19L1
uniprot id: F6YQP7
names: Similarity
messages: Belongs to the CWF19 family.

13616:GCAT
gene id: 13616:GCAT
uniprot id: H9H7A1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

13616:F7
gene id: 13616:F7
uniprot id: F7D6Z7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:RTN3
gene id: 13616:RTN3
uniprot id: A0A5F8HKC7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NIBAN3
gene id: 13616:NIBAN3
uniprot id: F6SVS0
names: Similarity
messages: Belongs to the Niban family.

13616:LOC100010137
gene id: 13616:LOC100010137
uniprot id: F7FSW2
names: Similarity
messages: Belongs to the sepiapterin reductase family.

13616:BNIP1
gene id: 13616:BNIP1
uniprot id: A0A5F8H3B7
names: Subcellular Location Annotation
messages: Membrane

13616:UBLCP1
gene id: 13616:UBLCP1
uniprot id: F6YKB6
names: Subcellular Location Annotation
messages: Nucleus

13616:GDE1
gene id: 13616:GDE1
uniprot id: A0A5F8GB52
uniprot id: F7FE75
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:LOC100010148
gene id: 13616:LOC100010148
uniprot id: F7E232
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:DNAI7
gene id: 13616:DNAI7
uniprot id: A0A5F8G3U3
uniprot id: A0A5F8H560
uniprot id: A0A5F8H5R7
names: Similarity
messages: Belongs to the DNAI7 family.

13616:GREM1
gene id: 13616:GREM1
uniprot id: F6V0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

13616:ATP6AP2
gene id: 13616:ATP6AP2
uniprot id: F6UI11
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

13616:HAPSTR1
gene id: 13616:HAPSTR1
uniprot id: F6YKN0
names: Subcellular Location Annotation
messages: Nucleus

13616:GLA
gene id: 13616:GLA
uniprot id: F6UZR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

13616:FZD8
gene id: 13616:FZD8
uniprot id: F7CDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

13616:EMG1
gene id: 13616:EMG1
uniprot id: A0A5F8GAG1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

13616:BMP5
gene id: 13616:BMP5
uniprot id: F7AD87
names: Similarity
messages: Belongs to the TGF-beta family.

13616:PDIA4
gene id: 13616:PDIA4
uniprot id: F6SNH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:NDUFA2
gene id: 13616:NDUFA2
uniprot id: F6W1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:monDomV1R1272
gene id: 13616:monDomV1R1272
uniprot id: A0A5F8HED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VTI1B
gene id: 13616:VTI1B
uniprot id: F6USP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

13616:ZFHX2
gene id: 13616:ZFHX2
uniprot id: F6UB49
names: Subcellular Location Annotation
messages: Nucleus

13616:MOG
gene id: 13616:MOG
uniprot id: F6ZHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

13616:LOC100031219
gene id: 13616:LOC100031219
uniprot id: F6RSG9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MDM4
gene id: 13616:MDM4
uniprot id: A0A5F8G9Z5
uniprot id: F7BAJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

13616:LOC100026637
gene id: 13616:LOC100026637
uniprot id: A0A5F8GU97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:LOC100020348
gene id: 13616:LOC100020348
uniprot id: F6YGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:JPH1
gene id: 13616:JPH1
uniprot id: F6RFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

13616:KCNH8
gene id: 13616:KCNH8
uniprot id: F7G6S7
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

13616:FNIP1
gene id: 13616:FNIP1
uniprot id: A0A5F8G300
uniprot id: F6Y4V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

13616:TPM4
gene id: 13616:TPM4
uniprot id: F7GGJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

13616:RFT1
gene id: 13616:RFT1
uniprot id: F7D428
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

13616:ARHGAP26
gene id: 13616:ARHGAP26
uniprot id: A0A5F8HHU2
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

13616:NECTIN3
gene id: 13616:NECTIN3
uniprot id: A0A5F8GC50
uniprot id: F7FTI1
names: Similarity
messages: Belongs to the nectin family.

13616:INPP5B
gene id: 13616:INPP5B
uniprot id: F6Y5S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

13616:LOC103093843
gene id: 13616:LOC103093843
uniprot id: F7BK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:UHRF1
gene id: 13616:UHRF1
uniprot id: F7DPG2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

13616:RHAG
gene id: 13616:RHAG
uniprot id: F6Z2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

13616:LOC100029238
gene id: 13616:LOC100029238
uniprot id: F6UDZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

13616:PVALEF
gene id: 13616:PVALEF
uniprot id: K7E0X2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

13616:WNT2
gene id: 13616:WNT2
uniprot id: Q2QL96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

13616:LOC100619142
gene id: 13616:LOC100619142
uniprot id: F6QSK9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:CHMP4C
gene id: 13616:CHMP4C
uniprot id: F7FS96
names: Similarity
messages: Belongs to the SNF7 family.

13616:PFAS
gene id: 13616:PFAS
uniprot id: A0A5F8H032
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

13616:MGST1
gene id: 13616:MGST1
uniprot id: F7FGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

13616:FAM76A
gene id: 13616:FAM76A
uniprot id: A0A5F8G818
uniprot id: A0A5F8GV49
names: Similarity
messages: Belongs to the FAM76 family.

13616:SLC25A37
gene id: 13616:SLC25A37
uniprot id: F7G676
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100009955
gene id: 13616:LOC100009955
uniprot id: F6TAE7
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

13616:GLRA2
gene id: 13616:GLRA2
uniprot id: F6SLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

13616:CRYBB3
gene id: 13616:CRYBB3
uniprot id: F7AUT2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:BRPF3
gene id: 13616:BRPF3
uniprot id: A0A5F8G9J0
uniprot id: F6UD32
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM134
gene id: 13616:TMEM134
uniprot id: F6WJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

13616:ANO4
gene id: 13616:ANO4
uniprot id: A0A5F8HAA1
uniprot id: F7FL71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100010920
gene id: 13616:LOC100010920
uniprot id: F7ESQ8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:KYNU
gene id: 13616:KYNU
uniprot id: F6Q3X0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CMPK2
gene id: 13616:CMPK2
uniprot id: F7ASM8
names: Similarity
messages: Belongs to the thymidylate kinase family.

13616:TNKS2
gene id: 13616:TNKS2
uniprot id: F7CDC2
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:FUCA2
gene id: 13616:FUCA2
uniprot id: F6TJX9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

13616:RFC1
gene id: 13616:RFC1
uniprot id: F7BBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

13616:TXLNA
gene id: 13616:TXLNA
uniprot id: F7FEQ0
names: Similarity
messages: Belongs to the taxilin family.

13616:LOC100017089
gene id: 13616:LOC100017089
uniprot id: F6XDL1
names: Similarity
messages: Belongs to the peptidase A1 family.

13616:TCP1
gene id: 13616:TCP1
uniprot id: Q9XT06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity).
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: centrosome
messages: cytosol

13616:LOC103092471
gene id: 13616:LOC103092471
uniprot id: A0A5F8HDP5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:DCAF10
gene id: 13616:DCAF10
uniprot id: F6Q3V3
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

13616:ENTPD7
gene id: 13616:ENTPD7
uniprot id: F7C8K3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:NFASC
gene id: 13616:NFASC
uniprot id: A0A5F8HEG8
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

13616:MAP2K2
gene id: 13616:MAP2K2
uniprot id: F6S9S9
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:PPM1G
gene id: 13616:PPM1G
uniprot id: F7F0V5
names: Similarity
messages: Belongs to the PP2C family.

13616:RIN2
gene id: 13616:RIN2
uniprot id: F6XCT8
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

13616:LOC103094304
gene id: 13616:LOC103094304
uniprot id: A0A5F8GLC9
names: Subcellular Location Annotation
messages: Nucleus

13616:ADGRG1
gene id: 13616:ADGRG1
uniprot id: F7GKY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

13616:MTERF3
gene id: 13616:MTERF3
uniprot id: F6QV92
names: Similarity
messages: Belongs to the mTERF family.

13616:CSTF1
gene id: 13616:CSTF1
uniprot id: F7ARW5
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100024753
gene id: 13616:LOC100024753
uniprot id: A0A5F8H0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GOLGA5
gene id: 13616:GOLGA5
uniprot id: F7GEH2
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

13616:SHROOM3
gene id: 13616:SHROOM3
uniprot id: F7GDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

13616:MSTO1
gene id: 13616:MSTO1
uniprot id: F6QEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

13616:ACE2
gene id: 13616:ACE2
uniprot id: F6WXR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

13616:LOC100019894
gene id: 13616:LOC100019894
uniprot id: F6YW40
names: Subcellular Location Annotation
messages: Membrane

13616:PTPN11
gene id: 13616:PTPN11
uniprot id: F6WVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

13616:NIPSNAP2
gene id: 13616:NIPSNAP2
uniprot id: F6ZWX7
names: Similarity
messages: Belongs to the NipSnap family.

13616:PKP2
gene id: 13616:PKP2
uniprot id: A0A5F8HBV7
names: Similarity
messages: Belongs to the beta-catenin family.

13616:LGI3
gene id: 13616:LGI3
uniprot id: F7AWE8
names: Subcellular Location Annotation
messages: Secreted

13616:DNAAF6
gene id: 13616:DNAAF6
uniprot id: F7DF68
names: Similarity
messages: Belongs to the PIH1 family.

13616:CPSF4
gene id: 13616:CPSF4
uniprot id: F7FVV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

13616:GOT1L1
gene id: 13616:GOT1L1
uniprot id: F7C035
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

13616:ZFTRAF1
gene id: 13616:ZFTRAF1
uniprot id: A0A5F8H580
uniprot id: F7F505
names: Similarity
messages: Belongs to the ZFTRAF1 family.

13616:CTSB
gene id: 13616:CTSB
uniprot id: F7ALZ4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:ACTL7A
gene id: 13616:ACTL7A
uniprot id: F6XB70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

13616:CDIP1
gene id: 13616:CDIP1
uniprot id: F7GEU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

13616:LOC103102954
gene id: 13616:LOC103102954
uniprot id: F6TAY5
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

13616:LOC100011527
gene id: 13616:LOC100011527
uniprot id: F7GEA2
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:WNT10A
gene id: 13616:WNT10A
uniprot id: F6SGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:IQCG
gene id: 13616:IQCG
uniprot id: F6QUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

13616:LCTL
gene id: 13616:LCTL
uniprot id: F6RDR6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

13616:EIF4H
gene id: 13616:EIF4H
uniprot id: A0A5F8G8Y9
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

13616:METTL6
gene id: 13616:METTL6
uniprot id: F7E9G8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

13616:GABRA5
gene id: 13616:GABRA5
uniprot id: F7C2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:PGK1
gene id: 13616:PGK1
uniprot id: F7C393
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

13616:NUDT2
gene id: 13616:NUDT2
uniprot id: A0A5F8GG60
names: Similarity
messages: Belongs to the Nudix hydrolase family.

13616:LOC100019150
gene id: 13616:LOC100019150
uniprot id: F7E8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024081
gene id: 13616:LOC100024081
uniprot id: F7EHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GIP
gene id: 13616:GIP
uniprot id: K7E4A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

13616:PSMC3IP
gene id: 13616:PSMC3IP
uniprot id: A0A5F8H0X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

13616:ZPBP
gene id: 13616:ZPBP
uniprot id: F6YX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

13616:ZNF330
gene id: 13616:ZNF330
uniprot id: F6SZ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: centromere
messages: nucleolus

13616:SLC66A1
gene id: 13616:SLC66A1
uniprot id: F7B3W8
names: Subcellular Location Annotation
messages: Membrane

13616:CARNMT1
gene id: 13616:CARNMT1
uniprot id: F6RI81
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

13616:EME1
gene id: 13616:EME1
uniprot id: H9H7R3
names: Similarity
messages: Belongs to the EME1/MMS4 family.

13616:FAM133B
gene id: 13616:FAM133B
uniprot id: F7FK91
names: Similarity
messages: Belongs to the FAM133 family.

13616:LOC100024582
gene id: 13616:LOC100024582
uniprot id: F7F0P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100028082
gene id: 13616:LOC100028082
uniprot id: A0A5F8H8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:USP5
gene id: 13616:USP5
uniprot id: F7CWU5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:RAB4B
gene id: 13616:RAB4B
uniprot id: F7GI49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

13616:GABRQ
gene id: 13616:GABRQ
uniprot id: A0A5F8H1S9
uniprot id: F6WX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:CYSLTR2
gene id: 13616:CYSLTR2
uniprot id: F6XJU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100013358
gene id: 13616:LOC100013358
uniprot id: F6X5U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CLCN3
gene id: 13616:CLCN3
uniprot id: A0A5F8G2D3
uniprot id: A0A5F8GIK7
uniprot id: A0A5F8HBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

13616:CAPN9
gene id: 13616:CAPN9
uniprot id: A0A5F8HHT2
names: Similarity
messages: Belongs to the peptidase C2 family.

13616:IDH1
gene id: 13616:IDH1
uniprot id: F6ZQM3
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

13616:EPHA4
gene id: 13616:EPHA4
uniprot id: F6XVY7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

13616:ATF7IP2
gene id: 13616:ATF7IP2
uniprot id: A0A5F8GQX1
uniprot id: F7E6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

13616:TMEM30A
gene id: 13616:TMEM30A
uniprot id: F7B4F8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

13616:LOC103104756
gene id: 13616:LOC103104756
uniprot id: A0A5F8GA77
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:RACK1
gene id: 13616:RACK1
uniprot id: F6VVG7
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

13616:LOC100031169
gene id: 13616:LOC100031169
uniprot id: F7E1H0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:BTF3L4
gene id: 13616:BTF3L4
uniprot id: F6SSU1
names: Similarity
messages: Belongs to the NAC-beta family.

13616:RPS20
gene id: 13616:RPS20
uniprot id: A0A5F8GPJ3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

13616:FAM53C
gene id: 13616:FAM53C
uniprot id: A0A5F8H9N6
names: Similarity
messages: Belongs to the FAM53 family.

13616:PPIL4
gene id: 13616:PPIL4
uniprot id: F6R2R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:SLC29A1
gene id: 13616:SLC29A1
uniprot id: A0A5F8GYL0
uniprot id: F7GJP9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

13616:QPCTL
gene id: 13616:QPCTL
uniprot id: F7DZS6
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

13616:HDX
gene id: 13616:HDX
uniprot id: A0A5F8GXA6
uniprot id: F6W4D6
names: Subcellular Location Annotation
messages: Nucleus

13616:TLR4
gene id: 13616:TLR4
uniprot id: F6Y6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

13616:CAV2
gene id: 13616:CAV2
uniprot id: A0A5F8GBL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

13616:XPA
gene id: 13616:XPA
uniprot id: F6TZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

13616:LOC100021887
gene id: 13616:LOC100021887
uniprot id: F7AI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100018166
gene id: 13616:LOC100018166
uniprot id: F6Q969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ZNF277
gene id: 13616:ZNF277
uniprot id: F6ZR18
names: Similarity
messages: Belongs to the ZNF277 family.

13616:LOC100013717
gene id: 13616:LOC100013717
uniprot id: F7BFQ5
names: Similarity
messages: Belongs to the SNF7 family.

13616:PNRC2
gene id: 13616:PNRC2
uniprot id: F7C7J9
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100015440
gene id: 13616:LOC100015440
uniprot id: F6R624
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

13616:CACNB3
gene id: 13616:CACNB3
uniprot id: A0A5F8G2H5
uniprot id: H9H6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

13616:PRDM5
gene id: 13616:PRDM5
uniprot id: F7GB24
names: Subcellular Location Annotation
messages: Nucleus

13616:ADGRG5
gene id: 13616:ADGRG5
uniprot id: A0A5F8HLE8
names: Subcellular Location Annotation
messages: Membrane

13616:ELF3
gene id: 13616:ELF3
uniprot id: F6XM40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PEX5
gene id: 13616:PEX5
uniprot id: A0A5F8HGT1
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

13616:TSEN54
gene id: 13616:TSEN54
uniprot id: A0A5F8G7Q3
uniprot id: F7DWA7
names: Similarity
messages: Belongs to the SEN54 family.

13616:PAQR3
gene id: 13616:PAQR3
uniprot id: F6S7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:AURKA
gene id: 13616:AURKA
uniprot id: F7ASA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

13616:ERAP1
gene id: 13616:ERAP1
uniprot id: F7GID7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:PKMYT1
gene id: 13616:PKMYT1
uniprot id: F7F1V1
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ATG16L1
gene id: 13616:ATG16L1
uniprot id: A0A5F8HCY0
uniprot id: F6ZGZ5
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

13616:LOC100029345
gene id: 13616:LOC100029345
uniprot id: A0A5F8H096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

13616:SLC39A8
gene id: 13616:SLC39A8
uniprot id: F7DLB3
names: Subcellular Location Annotation
messages: Membrane

13616:GRB7
gene id: 13616:GRB7
uniprot id: F6WKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

13616:LOC100023173
gene id: 13616:LOC100023173
uniprot id: F6YL42
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100028608
gene id: 13616:LOC100028608
uniprot id: F6SAU5
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:NQO1
gene id: 13616:NQO1
uniprot id: F7CXV7
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

13616:CITED4
gene id: 13616:CITED4
uniprot id: F6VBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

13616:TSSK6
gene id: 13616:TSSK6
uniprot id: F6WPR1
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100029949
gene id: 13616:LOC100029949
uniprot id: F7FSJ3
names: Subcellular Location Annotation
messages: Membrane

13616:PRPF19
gene id: 13616:PRPF19
uniprot id: F7FWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

13616:TLE5
gene id: 13616:TLE5
uniprot id: F7ECH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

13616:monDomV1R1225
gene id: 13616:monDomV1R1225
uniprot id: F7BT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HINT2
gene id: 13616:HINT2
uniprot id: F6RG00
names: Similarity
messages: Belongs to the HINT family.

13616:ZEB1
gene id: 13616:ZEB1
uniprot id: A0A5F8G233
uniprot id: F6Y0B4
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

13616:SLC35F2
gene id: 13616:SLC35F2
uniprot id: F7E7K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

13616:CACNB2
gene id: 13616:CACNB2
uniprot id: A0A5F8GQ07
uniprot id: A0A5F8H7D7
uniprot id: F6REU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

13616:LOC100022399
gene id: 13616:LOC100022399
uniprot id: F6XFI1
names: Subcellular Location Annotation
messages: Membrane

13616:EIF4E3
gene id: 13616:EIF4E3
uniprot id: F7D857
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

13616:PLRG1
gene id: 13616:PLRG1
uniprot id: A0A5F8GXT6
uniprot id: F7G7S0
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

13616:KCNC4
gene id: 13616:KCNC4
uniprot id: A0A5F8GY55
uniprot id: F6XGB3
names: Subcellular Location Annotation
messages: Membrane

13616:CALHM2
gene id: 13616:CALHM2
uniprot id: F7F446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:IRF2BP2
gene id: 13616:IRF2BP2
uniprot id: F7GEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

13616:INTS13
gene id: 13616:INTS13
uniprot id: F6ZC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

13616:PIAS1
gene id: 13616:PIAS1
uniprot id: A0A5F8GDT2
uniprot id: F7B6F8
names: Similarity
messages: Belongs to the PIAS family.

13616:TTC39B
gene id: 13616:TTC39B
uniprot id: A0A5F8GCQ6
uniprot id: A0A5F8H663
uniprot id: F7CGT6
names: Similarity
messages: Belongs to the TTC39 family.

13616:RAB27B
gene id: 13616:RAB27B
uniprot id: A0A5F8GU64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

13616:RAB3IP
gene id: 13616:RAB3IP
uniprot id: F7F670
names: Similarity
messages: Belongs to the SEC2 family.

13616:HMOX1
gene id: 13616:HMOX1
uniprot id: F7CK49
names: Similarity
messages: Belongs to the heme oxygenase family.

13616:DCT
gene id: 13616:DCT
uniprot id: F7CPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

13616:MCTP2
gene id: 13616:MCTP2
uniprot id: F7C9M4
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100023334
gene id: 13616:LOC100023334
uniprot id: F6Q121
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100020045
gene id: 13616:LOC100020045
uniprot id: F6PYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GNB4
gene id: 13616:GNB4
uniprot id: F7G3J2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:LOC100019902
gene id: 13616:LOC100019902
uniprot id: F6SRP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PTGES3
gene id: 13616:PTGES3
uniprot id: H9H7I9
uniprot id: K7E0U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

13616:LOC100010526
gene id: 13616:LOC100010526
uniprot id: F6Q4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:TIMM22
gene id: 13616:TIMM22
uniprot id: F6UAF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

13616:DHRS7
gene id: 13616:DHRS7
uniprot id: F7CCB2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:C3AR1
gene id: 13616:C3AR1
uniprot id: A0A5F8H9U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

13616:ENTR1
gene id: 13616:ENTR1
uniprot id: F7BSG6
names: Similarity
messages: Belongs to the ENTR1 family.

13616:ART1
gene id: 13616:ART1
uniprot id: F6ZXV5
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

13616:CCR4
gene id: 13616:CCR4
uniprot id: F7BE29
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:PSMA6
gene id: 13616:PSMA6
uniprot id: F7DYR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:KCNE3
gene id: 13616:KCNE3
uniprot id: F6WTC2
names: Similarity
messages: Belongs to the potassium channel KCNE family.

13616:ARG1
gene id: 13616:ARG1
uniprot id: F7B5B3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

13616:GDF2
gene id: 13616:GDF2
uniprot id: A0A5F8GIG5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:T2R3A
gene id: 13616:T2R3A
uniprot id: Q2ABA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:GFAP
gene id: 13616:GFAP
uniprot id: F6WYV7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:MRAP
gene id: 13616:MRAP
uniprot id: A0A5F8GHV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CTPS2
gene id: 13616:CTPS2
uniprot id: F6XYN7
uniprot id: K7E4X2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

13616:SEMA6D
gene id: 13616:SEMA6D
uniprot id: A0A5F8GG01
uniprot id: A0A5F8H3V9
uniprot id: F7EIR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PKNOX2
gene id: 13616:PKNOX2
uniprot id: F7D6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

13616:MODO-UJ
gene id: 13616:MODO-UJ
uniprot id: C6ZIV6
names: Similarity
messages: Belongs to the MHC class I family.

13616:GRHL3
gene id: 13616:GRHL3
uniprot id: F7FQ08
names: Subcellular Location Annotation
messages: Nucleus

13616:CIAO1
gene id: 13616:CIAO1
uniprot id: F7F2Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

13616:TAF4
gene id: 13616:TAF4
uniprot id: F7DMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

13616:MYOC
gene id: 13616:MYOC
uniprot id: A0A5F8HHZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DOLK
gene id: 13616:DOLK
uniprot id: F6U8P7
names: Similarity
messages: Belongs to the polyprenol kinase family.

13616:WDR82
gene id: 13616:WDR82
uniprot id: F6UGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

13616:FAM168B
gene id: 13616:FAM168B
uniprot id: F7B2L4
names: Similarity
messages: Belongs to the FAM168 family.

13616:NEMP2
gene id: 13616:NEMP2
uniprot id: F6UZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

13616:BMP10
gene id: 13616:BMP10
uniprot id: F7GDY5
names: Similarity
messages: Belongs to the TGF-beta family.

13616:CDK19
gene id: 13616:CDK19
uniprot id: A0A5F8H986
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:G6PC3
gene id: 13616:G6PC3
uniprot id: F7G6N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

13616:CTNNA1
gene id: 13616:CTNNA1
uniprot id: F7ALE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

13616:FAM219B
gene id: 13616:FAM219B
uniprot id: A0A5F8GX09
names: Similarity
messages: Belongs to the FAM219 family.

13616:PRKRA
gene id: 13616:PRKRA
uniprot id: F6RX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

13616:HTR2A
gene id: 13616:HTR2A
uniprot id: F6WZZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

13616:ZC3H12A
gene id: 13616:ZC3H12A
uniprot id: F7CZ87
names: Similarity
messages: Belongs to the ZC3H12 family.

13616:RPL10A
gene id: 13616:RPL10A
uniprot id: F6UB55
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

13616:CENPH
gene id: 13616:CENPH
uniprot id: F6QC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

13616:MYF5
gene id: 13616:MYF5
uniprot id: F7FIX4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

13616:TAF11
gene id: 13616:TAF11
uniprot id: A0A5F8GX65
names: Similarity
messages: Belongs to the TAF11 family.

13616:ELAC1
gene id: 13616:ELAC1
uniprot id: F7AQD1
names: Subunit
messages: Homodimer.

13616:PSMG2
gene id: 13616:PSMG2
uniprot id: F7CBG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

13616:GPC2
gene id: 13616:GPC2
uniprot id: F6SV42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

13616:FGF6
gene id: 13616:FGF6
uniprot id: A0A5F8GPQ2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:NOL10
gene id: 13616:NOL10
uniprot id: A0A5F8GGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

13616:ZPBP2
gene id: 13616:ZPBP2
uniprot id: F7GKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

13616:TMEM35A
gene id: 13616:TMEM35A
uniprot id: F7DFA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

13616:MAPK6
gene id: 13616:MAPK6
uniprot id: F6V2H6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

13616:TRADD
gene id: 13616:TRADD
uniprot id: F7FRX7
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

13616:EXO1
gene id: 13616:EXO1
uniprot id: F6PWE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

13616:DBNDD1
gene id: 13616:DBNDD1
uniprot id: A0A5F8GT25
names: Similarity
messages: Belongs to the dysbindin family.

13616:MTMR12
gene id: 13616:MTMR12
uniprot id: F7BDM3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:B3GNT5
gene id: 13616:B3GNT5
uniprot id: F7CQU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100619630
gene id: 13616:LOC100619630
uniprot id: A0A5F8G6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TPK1
gene id: 13616:TPK1
uniprot id: A0A5F8GTE9
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

13616:OVOL2
gene id: 13616:OVOL2
uniprot id: F7GFR3
names: Subcellular Location Annotation
messages: Nucleus

13616:CXCR5
gene id: 13616:CXCR5
uniprot id: F7DTL3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100017586
gene id: 13616:LOC100017586
uniprot id: F6RBR7
names: Similarity
messages: Belongs to the actin family.

13616:LBX1
gene id: 13616:LBX1
uniprot id: A0A5F8GSD2
names: Subcellular Location Annotation
messages: Nucleus

13616:GNA11
gene id: 13616:GNA11
uniprot id: F7ECA6
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

13616:ANAPC13
gene id: 13616:ANAPC13
uniprot id: F7B352
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

13616:TJP2
gene id: 13616:TJP2
uniprot id: A0A5F8GY42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:GABRG1
gene id: 13616:GABRG1
uniprot id: F7A086
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:LOC100013294
gene id: 13616:LOC100013294
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:TNFRSF21
gene id: 13616:TNFRSF21
uniprot id: F6Z1T7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PCMTD1
gene id: 13616:PCMTD1
uniprot id: F6QTB4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

13616:LOC100016601
gene id: 13616:LOC100016601
uniprot id: F7EU36
names: Similarity
messages: Belongs to the actin family.

13616:TTC27
gene id: 13616:TTC27
uniprot id: A0A5F8HEM5
names: Similarity
messages: Belongs to the TTC27 family.

13616:AVP
gene id: 13616:AVP
uniprot id: F7D0Q1
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:SYS1
gene id: 13616:SYS1
uniprot id: A0A5F8H0R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

13616:KCNA5
gene id: 13616:KCNA5
uniprot id: F7EBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

13616:IL18R1
gene id: 13616:IL18R1
uniprot id: F7F019
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

13616:SPICE1
gene id: 13616:SPICE1
uniprot id: A0A5F8G7S9
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

13616:CHN2
gene id: 13616:CHN2
uniprot id: F6XXK5
names: Function
messages: GTPase-activating protein for p21-rac.

13616:CCDC172
gene id: 13616:CCDC172
uniprot id: F7A9G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

13616:LOC100023056
gene id: 13616:LOC100023056
uniprot id: F7DGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NOL6
gene id: 13616:NOL6
uniprot id: F6ZJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

13616:LOC100029158
gene id: 13616:LOC100029158
uniprot id: F7EH45
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SCOC
gene id: 13616:SCOC
uniprot id: F6V246
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

13616:SLC1A1
gene id: 13616:SLC1A1
uniprot id: F6T507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:LOC100023079
gene id: 13616:LOC100023079
uniprot id: F6U8J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC12A1
gene id: 13616:SLC12A1
uniprot id: A0A5F8GVX4
uniprot id: F7CEB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:NASP
gene id: 13616:NASP
uniprot id: F7CC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

13616:LOC103096413
gene id: 13616:LOC103096413
uniprot id: F6YQE3
names: Subcellular Location Annotation
messages: Secreted

13616:ZNF532
gene id: 13616:ZNF532
uniprot id: F7AR81
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

13616:MVD
gene id: 13616:MVD
uniprot id: F6Y9W8
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

13616:TBL3
gene id: 13616:TBL3
uniprot id: F7FYU7
names: Subcellular Location Annotation
messages: nucleolus

13616:PSME1
gene id: 13616:PSME1
uniprot id: F7GBS5
names: Similarity
messages: Belongs to the PA28 family.

13616:INTS2
gene id: 13616:INTS2
uniprot id: F6X1I7
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

13616:LOC103103968
gene id: 13616:LOC103103968
uniprot id: A0A5F8H357
names: Subcellular Location Annotation
messages: Nucleus

13616:GPR182
gene id: 13616:GPR182
uniprot id: H9H8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ENPP1
gene id: 13616:ENPP1
uniprot id: F7BSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

13616:MTMR6
gene id: 13616:MTMR6
uniprot id: A0A5F8GXW6
uniprot id: F7CX78
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:LOC100010256
gene id: 13616:LOC100010256
uniprot id: F7CA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STPG1
gene id: 13616:STPG1
uniprot id: A0A5F8G1Z8
uniprot id: F7FBL9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:LOC100019436
gene id: 13616:LOC100019436
uniprot id: F6VFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PIGS
gene id: 13616:PIGS
uniprot id: F6QSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:AACS
gene id: 13616:AACS
uniprot id: F7EI39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

13616:LOC100015820
gene id: 13616:LOC100015820
uniprot id: F6V2C5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:ROPN1L
gene id: 13616:ROPN1L
uniprot id: F7DF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

13616:LOC100023204
gene id: 13616:LOC100023204
uniprot id: A0A5F8HK09
uniprot id: F7D0J8
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:PEX19
gene id: 13616:PEX19
uniprot id: F7AX56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

13616:LLGL1
gene id: 13616:LLGL1
uniprot id: F6Z9W6
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

13616:MANF
gene id: 13616:MANF
uniprot id: F7EGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

13616:PCOLCE2
gene id: 13616:PCOLCE2
uniprot id: F6TZS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:NIPA1
gene id: 13616:NIPA1
uniprot id: F6X3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:SLC35C1
gene id: 13616:SLC35C1
uniprot id: F6WL14
names: Subcellular Location Annotation
messages: Membrane

13616:TCTA
gene id: 13616:TCTA
uniprot id: F7CSS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

13616:COQ8A
gene id: 13616:COQ8A
uniprot id: F7GCL0
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

13616:C9
gene id: 13616:C9
uniprot id: F7G7P1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

13616:FGF5
gene id: 13616:FGF5
uniprot id: F6S897
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:PSD3
gene id: 13616:PSD3
uniprot id: A0A5F8GLW2
names: Subcellular Location Annotation
messages: ruffle membrane

13616:LOC103099050
gene id: 13616:LOC103099050
uniprot id: A0A5F8G6J1
names: Similarity
messages: Belongs to the peptidase S51 family.

13616:KCNQ4
gene id: 13616:KCNQ4
uniprot id: F7B5A9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SMARCAL1
gene id: 13616:SMARCAL1
uniprot id: F6SKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

13616:TET1
gene id: 13616:TET1
uniprot id: F6XCP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

13616:RPF2
gene id: 13616:RPF2
uniprot id: A0A5F8H2N5
uniprot id: F7F2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

13616:GDAP2
gene id: 13616:GDAP2
uniprot id: F7A1V0
names: Similarity
messages: Belongs to the GDAP2 family.

13616:PDSS1
gene id: 13616:PDSS1
uniprot id: F7DHD1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

13616:ATP8A1
gene id: 13616:ATP8A1
uniprot id: A0A5F8G638
uniprot id: A0A5F8G7E0
uniprot id: A0A5F8GPA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:OGT
gene id: 13616:OGT
uniprot id: F6Y3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

13616:REM2
gene id: 13616:REM2
uniprot id: F7A1Z3
names: Subcellular Location Annotation
messages: Cell membrane

13616:LOC100026480
gene id: 13616:LOC100026480
uniprot id: A0A5F8GFZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

13616:LOC100015103
gene id: 13616:LOC100015103
uniprot id: A0A5F8G8R6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

13616:MTHFS
gene id: 13616:MTHFS
uniprot id: F6SFK7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

13616:TMED2
gene id: 13616:TMED2
uniprot id: A0A5F8GH98
uniprot id: A0A5F8GS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

13616:MECP2
gene id: 13616:MECP2
uniprot id: F6TJ54
names: Subcellular Location Annotation
messages: Nucleus

13616:AGPAT1
gene id: 13616:AGPAT1
uniprot id: A0A5F8G731
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

13616:LOC100021749
gene id: 13616:LOC100021749
uniprot id: F6PZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:EGR1
gene id: 13616:EGR1
uniprot id: A0A5F8HGN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

13616:PTAFR
gene id: 13616:PTAFR
uniprot id: F7G9B8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

13616:TPP1
gene id: 13616:TPP1
uniprot id: F7FRR4
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

13616:NDUFB8
gene id: 13616:NDUFB8
uniprot id: A0A5F8GSV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:RANBP9
gene id: 13616:RANBP9
uniprot id: F6QUG9
names: Similarity
messages: Belongs to the RANBP9/10 family.

13616:NSRP1
gene id: 13616:NSRP1
uniprot id: F6VV70
names: Similarity
messages: Belongs to the NSRP1 family.

13616:ERLIN1
gene id: 13616:ERLIN1
uniprot id: F7CJY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

13616:monDomV1R1254
gene id: 13616:monDomV1R1254
uniprot id: F6V7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:C2H3orf70
gene id: 13616:C2H3orf70
uniprot id: F7DI48
names: Similarity
messages: Belongs to the UPF0524 family.

13616:LOC103094714
gene id: 13616:LOC103094714
uniprot id: F6X920
names: Function
messages: May be involved in transcriptional regulation.

13616:HEXIM1
gene id: 13616:HEXIM1
uniprot id: F7E876
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

13616:STK39
gene id: 13616:STK39
uniprot id: F7FZW9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

13616:GJB5
gene id: 13616:GJB5
uniprot id: F7EJS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:LOC100018242
gene id: 13616:LOC100018242
uniprot id: F6UWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

13616:SNF8
gene id: 13616:SNF8
uniprot id: F6YG55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

13616:SPA17
gene id: 13616:SPA17
uniprot id: O62771
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Homodimer. May interact with ROPN1 (By similarity).
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
messages: Testis- and sperm-specific.

13616:DNASE1L1
gene id: 13616:DNASE1L1
uniprot id: F6RGU8
names: Similarity
messages: Belongs to the DNase I family.

13616:WASL
gene id: 13616:WASL
uniprot id: F6TLC0
names: Subcellular Location Annotation
messages: Nucleus

13616:SPC25
gene id: 13616:SPC25
uniprot id: F7BJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

13616:LOC100032028
gene id: 13616:LOC100032028
uniprot id: F6SPU8
names: Similarity
messages: Belongs to the PRORSD1 family.

13616:PEMT
gene id: 13616:PEMT
uniprot id: F6WK67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

13616:NUDCD1
gene id: 13616:NUDCD1
uniprot id: F7BGF0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:ADGB
gene id: 13616:ADGB
uniprot id: A0A5F8G1N3
uniprot id: A0A5F8G9G5
uniprot id: F6RUJ9
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NPY
gene id: 13616:NPY
uniprot id: F6VPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

13616:LYVE1
gene id: 13616:LYVE1
uniprot id: F7AL98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GSK3B
gene id: 13616:GSK3B
uniprot id: A0A5F8GBH0
uniprot id: A0A5F8HIG1
uniprot id: F6PGQ1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

13616:FEV
gene id: 13616:FEV
uniprot id: F6WXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PINLYP
gene id: 13616:PINLYP
uniprot id: H9H633
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

13616:GPR18
gene id: 13616:GPR18
uniprot id: F7EB53
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TMEM106A
gene id: 13616:TMEM106A
uniprot id: F7CF63
names: Similarity
messages: Belongs to the TMEM106 family.

13616:PRPSAP2
gene id: 13616:PRPSAP2
uniprot id: F7BIR5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

13616:JUNB
gene id: 13616:JUNB
uniprot id: A0A5F8GZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

13616:PTPRA
gene id: 13616:PTPRA
uniprot id: A0A5F8H677
uniprot id: F7G6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

13616:ITGA2
gene id: 13616:ITGA2
uniprot id: F6RXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:LPIN3
gene id: 13616:LPIN3
uniprot id: F7AZN5
names: Similarity
messages: Belongs to the lipin family.

13616:CHAC1
gene id: 13616:CHAC1
uniprot id: F6TFR6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

13616:LOC100011021
gene id: 13616:LOC100011021
uniprot id: F6ZEA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

13616:RNASEH1
gene id: 13616:RNASEH1
uniprot id: F7FKT3
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

13616:C8G
gene id: 13616:C8G
uniprot id: F6XCK8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:AUP1
gene id: 13616:AUP1
uniprot id: A0A5F8G3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Membrane

13616:NEMP1
gene id: 13616:NEMP1
uniprot id: A0A5F8HES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

13616:TRAK2
gene id: 13616:TRAK2
uniprot id: F7B9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

13616:ST3GAL5
gene id: 13616:ST3GAL5
uniprot id: A0A5F8GW05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:COQ10B
gene id: 13616:COQ10B
uniprot id: F6YFX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

13616:LOC100022070
gene id: 13616:LOC100022070
uniprot id: F6W8S3
names: Similarity
messages: Belongs to the ficolin lectin family.

13616:VN2R632
gene id: 13616:VN2R632
uniprot id: A0A5F8GH37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ISCA1
gene id: 13616:ISCA1
uniprot id: F7GBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

13616:HAUS1
gene id: 13616:HAUS1
uniprot id: F6TZI7
uniprot id: K7E4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

13616:CERT1
gene id: 13616:CERT1
uniprot id: A0A5F8GSL3
uniprot id: A0A5F8H2W9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

13616:LOC100011905
gene id: 13616:LOC100011905
uniprot id: K7E0Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:CAMSAP1
gene id: 13616:CAMSAP1
uniprot id: F7E1H7
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

13616:LOC100023657
gene id: 13616:LOC100023657
uniprot id: F7C951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:F13A1
gene id: 13616:F13A1
uniprot id: F6VTU1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

13616:MC2R
gene id: 13616:MC2R
uniprot id: F7CBR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

13616:LOC100027243
gene id: 13616:LOC100027243
uniprot id: F7CWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:SEMA4C
gene id: 13616:SEMA4C
uniprot id: F6UE98
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:STAT6
gene id: 13616:STAT6
uniprot id: H9H8T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:JPH2
gene id: 13616:JPH2
uniprot id: F7FLU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

13616:LHX6
gene id: 13616:LHX6
uniprot id: F6TTC0
names: Subcellular Location Annotation
messages: Nucleus

13616:NPTX2
gene id: 13616:NPTX2
uniprot id: F7BVD5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MGAT5
gene id: 13616:MGAT5
uniprot id: A0A5F8GJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

13616:CCL20
gene id: 13616:CCL20
uniprot id: K7E0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:ANXA4
gene id: 13616:ANXA4
uniprot id: F7GDF3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

13616:MRPS2
gene id: 13616:MRPS2
uniprot id: A0A5F8HAM2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

13616:CPS1
gene id: 13616:CPS1
uniprot id: A0A5F8H2V7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DEF8
gene id: 13616:DEF8
uniprot id: F7CTD5
names: Similarity
messages: Belongs to the DEF8 family.

13616:GNG14
gene id: 13616:GNG14
uniprot id: A0A5F8H6V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:YWHAH
gene id: 13616:YWHAH
uniprot id: F6WA79
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:LOC100617304
gene id: 13616:LOC100617304
uniprot id: A0A5F8GIS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100032852
gene id: 13616:LOC100032852
uniprot id: A0A5F8GZR6
names: Subcellular Location Annotation
messages: Membrane

13616:CACNB4
gene id: 13616:CACNB4
uniprot id: A0A5F8HIV3
uniprot id: B6IDG2
uniprot id: F6Q927
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

13616:SLC25A30
gene id: 13616:SLC25A30
uniprot id: F7FI91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:COG8
gene id: 13616:COG8
uniprot id: F6YGC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

13616:TWF1
gene id: 13616:TWF1
uniprot id: F7GD77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

13616:NLGN3
gene id: 13616:NLGN3
uniprot id: D2X2I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

13616:LOC100011610
gene id: 13616:LOC100011610
uniprot id: F7G461
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:CERS6
gene id: 13616:CERS6
uniprot id: A0A5F8G7S2
uniprot id: K7E682
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:CTSH
gene id: 13616:CTSH
uniprot id: F6RXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:UBL4A
gene id: 13616:UBL4A
uniprot id: F7BQ80
names: Subcellular Location Annotation
messages: cytosol

13616:LOC100017914
gene id: 13616:LOC100017914
uniprot id: F6U2X4
names: Subcellular Location Annotation
messages: Membrane

13616:EVX1
gene id: 13616:EVX1
uniprot id: F6USZ9
names: Subcellular Location Annotation
messages: Nucleus

13616:GJA8
gene id: 13616:GJA8
uniprot id: F7BI06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:DNAJC24
gene id: 13616:DNAJC24
uniprot id: F7BJ34
names: Similarity
messages: Belongs to the DPH4 family.

13616:IL17A
gene id: 13616:IL17A
uniprot id: F6YYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

13616:CHD2
gene id: 13616:CHD2
uniprot id: F6ZM50
names: Subcellular Location Annotation
messages: Nucleus

13616:SPTLC2
gene id: 13616:SPTLC2
uniprot id: F7E6T2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

13616:NMU
gene id: 13616:NMU
uniprot id: F6V218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

13616:UTP23
gene id: 13616:UTP23
uniprot id: F6UDS3
names: Subcellular Location Annotation
messages: nucleolus

13616:ARL2
gene id: 13616:ARL2
uniprot id: F6SBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

13616:LOC100033297
gene id: 13616:LOC100033297
uniprot id: F7FAG1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:FZD2
gene id: 13616:FZD2
uniprot id: F6RKF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:COPA
gene id: 13616:COPA
uniprot id: F7BJZ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

13616:TDP2
gene id: 13616:TDP2
uniprot id: A0A5F8GEF8
uniprot id: K7E4B3
names: Subcellular Location Annotation
messages: PML body

13616:ERCC4
gene id: 13616:ERCC4
uniprot id: F6U5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

13616:OCIAD1
gene id: 13616:OCIAD1
uniprot id: F7EME9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

13616:AKAP8L
gene id: 13616:AKAP8L
uniprot id: F7ASB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

13616:CCSER2
gene id: 13616:CCSER2
uniprot id: A0A5F8GCG8
uniprot id: A0A5F8GHW6
names: Similarity
messages: Belongs to the CCSER family.

13616:GPR158
gene id: 13616:GPR158
uniprot id: F6PWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:FBLN7
gene id: 13616:FBLN7
uniprot id: F7GEP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ENKUR
gene id: 13616:ENKUR
uniprot id: F6PUB7
names: Subcellular Location Annotation
messages: cilium axoneme

13616:ROMO1
gene id: 13616:ROMO1
uniprot id: F7BX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

13616:LOC100016508
gene id: 13616:LOC100016508
uniprot id: A0A5F8HAT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

13616:GUCY1A1
gene id: 13616:GUCY1A1
uniprot id: F7BAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

13616:CEP57
gene id: 13616:CEP57
uniprot id: A0A5F8H3Z7
names: Similarity
messages: Belongs to the translokin family.

13616:SLC9A2
gene id: 13616:SLC9A2
uniprot id: F7DZW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

13616:TIMM17B
gene id: 13616:TIMM17B
uniprot id: F6XNC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ATXN7L3
gene id: 13616:ATXN7L3
uniprot id: F7DF88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

13616:TMA16
gene id: 13616:TMA16
uniprot id: F7GEJ0
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

13616:VPS45
gene id: 13616:VPS45
uniprot id: F7AE31
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

13616:LOC103106071
gene id: 13616:LOC103106071
uniprot id: F7FTI4
names: Subcellular Location Annotation
messages: Nucleus

13616:CDKN3
gene id: 13616:CDKN3
uniprot id: A0A5F8HE70
uniprot id: F6UZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

13616:MRPL37
gene id: 13616:MRPL37
uniprot id: H9H804
names: Subcellular Location Annotation
messages: Mitochondrion

13616:KDM5B
gene id: 13616:KDM5B
uniprot id: A0A5F8GL11
uniprot id: F6T8F3
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

13616:DNAJC16
gene id: 13616:DNAJC16
uniprot id: F7G145
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

13616:ZHX1
gene id: 13616:ZHX1
uniprot id: F6QW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

13616:LOC100016032
gene id: 13616:LOC100016032
uniprot id: F6RZ22
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

13616:LOC100023655
gene id: 13616:LOC100023655
uniprot id: A0A5F8GPP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

13616:T2R23
gene id: 13616:T2R23
uniprot id: Q2AB96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:CXCL13
gene id: 13616:CXCL13
uniprot id: A0A5F8GSS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:CPNE2
gene id: 13616:CPNE2
uniprot id: A0A5F8GR65
names: Similarity
messages: Belongs to the copine family.

13616:LOC100016060
gene id: 13616:LOC100016060
uniprot id: F7GH03
names: Similarity
messages: Belongs to the globin family.

13616:RPA1
gene id: 13616:RPA1
uniprot id: F6YRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

13616:WASF2
gene id: 13616:WASF2
uniprot id: F7FLU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

13616:DDR2
gene id: 13616:DDR2
uniprot id: A0A5F8H9N5
names: Subcellular Location Annotation
messages: Membrane

13616:MYLK
gene id: 13616:MYLK
uniprot id: A0A5F8H252
uniprot id: F6PR65
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

13616:RPS3A
gene id: 13616:RPS3A
uniprot id: F7ESW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

13616:PARD6G
gene id: 13616:PARD6G
uniprot id: A0A5F8H752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

13616:SATB2
gene id: 13616:SATB2
uniprot id: F7E1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

13616:IL18
gene id: 13616:IL18
uniprot id: A0A5F8GTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

13616:LOC100017021
gene id: 13616:LOC100017021
uniprot id: F7GKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NTHL1
gene id: 13616:NTHL1
uniprot id: F6YUY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

13616:IHH
gene id: 13616:IHH
uniprot id: F6XEQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

13616:RORC
gene id: 13616:RORC
uniprot id: A0A5F8G5E3
uniprot id: F6R6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:CDR2
gene id: 13616:CDR2
uniprot id: F7BJ14
names: Similarity
messages: Belongs to the CDR2 family.

13616:TXK
gene id: 13616:TXK
uniprot id: F6ZAP5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:RNF168
gene id: 13616:RNF168
uniprot id: F6XBK7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

13616:SORD
gene id: 13616:SORD
uniprot id: F7GFN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Mitochondrion membrane
messages: flagellum

13616:TMC8
gene id: 13616:TMC8
uniprot id: F6T5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

13616:LOC100022107
gene id: 13616:LOC100022107
uniprot id: F6PZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CCDC39
gene id: 13616:CCDC39
uniprot id: A0A5F8GP59
uniprot id: F7G3V1
names: Similarity
messages: Belongs to the CCDC39 family.

13616:RRP1
gene id: 13616:RRP1
uniprot id: A0A5F8HFN1
names: Similarity
messages: Belongs to the RRP1 family.

13616:LOC100026263
gene id: 13616:LOC100026263
uniprot id: A0A5F8G5A1
uniprot id: F6V733
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:TBPL1
gene id: 13616:TBPL1
uniprot id: F7F0J5
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

13616:FGB
gene id: 13616:FGB
uniprot id: F7FX25
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

13616:LYZ
gene id: 13616:LYZ
uniprot id: F7A2F0
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

13616:EDEM2
gene id: 13616:EDEM2
uniprot id: A0A5F8HKP9
uniprot id: F6SNH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:NUS1
gene id: 13616:NUS1
uniprot id: F7CFL0
names: Similarity
messages: Belongs to the UPP synthase family.

13616:ARL4C
gene id: 13616:ARL4C
uniprot id: F7ABF7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:PRSS12
gene id: 13616:PRSS12
uniprot id: F7FP84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100010284
gene id: 13616:LOC100010284
uniprot id: F7CBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IFN3
gene id: 13616:IFN3
uniprot id: A8E6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

13616:CRH
gene id: 13616:CRH
uniprot id: F6UTQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

13616:PTX4
gene id: 13616:PTX4
uniprot id: F7G8Q0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100026503
gene id: 13616:LOC100026503
uniprot id: A0A5F8GFZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

13616:AARS1
gene id: 13616:AARS1
uniprot id: F7ERQ8
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

13616:MAPKAPK3
gene id: 13616:MAPKAPK3
uniprot id: F7CUT8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ALDH7A1
gene id: 13616:ALDH7A1
uniprot id: F7E9M6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

13616:LOC100619854
gene id: 13616:LOC100619854
uniprot id: F6SNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TCP11L1
gene id: 13616:TCP11L1
uniprot id: F6XSJ5
names: Similarity
messages: Belongs to the TCP11 family.

13616:ADCK5
gene id: 13616:ADCK5
uniprot id: F7G7M7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

13616:FZD7
gene id: 13616:FZD7
uniprot id: F7A659
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:HSPA13
gene id: 13616:HSPA13
uniprot id: F6SPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

13616:HTR5A
gene id: 13616:HTR5A
uniprot id: A0A5F8GY28
uniprot id: F7FL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PIGG
gene id: 13616:PIGG
uniprot id: F6SKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:FOXJ3
gene id: 13616:FOXJ3
uniprot id: A0A5F8HI89
uniprot id: F6WWW5
names: Subcellular Location Annotation
messages: Nucleus

13616:RPS19
gene id: 13616:RPS19
uniprot id: H9H6D3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

13616:CCNE1
gene id: 13616:CCNE1
uniprot id: A0A5F8HBJ0
names: Similarity
messages: Belongs to the cyclin family.

13616:ARRDC2
gene id: 13616:ARRDC2
uniprot id: H9H6I2
names: Similarity
messages: Belongs to the arrestin family.

13616:LOC100031238
gene id: 13616:LOC100031238
uniprot id: A0A5F8G5B2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:KIN
gene id: 13616:KIN
uniprot id: F7CHY4
names: Similarity
messages: Belongs to the KIN17 family.

13616:MYORG
gene id: 13616:MYORG
uniprot id: A0A5F8GDR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

13616:SFR1
gene id: 13616:SFR1
uniprot id: F7FIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

13616:IMPDH2
gene id: 13616:IMPDH2
uniprot id: A0A5F8GE87
uniprot id: F7DTY4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

13616:CRBN
gene id: 13616:CRBN
uniprot id: F6SVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

13616:UBAP2L
gene id: 13616:UBAP2L
uniprot id: A0A5F8GNC4
uniprot id: F6WHV1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:LOC100010706
gene id: 13616:LOC100010706
uniprot id: F6YIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

13616:PIF1
gene id: 13616:PIF1
uniprot id: F7ET02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

13616:MYSM1
gene id: 13616:MYSM1
uniprot id: F7CU00
names: Similarity
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.

13616:AVPR1B
gene id: 13616:AVPR1B
uniprot id: F6VJ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

13616:LOC100024791
gene id: 13616:LOC100024791
uniprot id: F7F1D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP6C
gene id: 13616:PPP6C
uniprot id: A0A5F8HHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

13616:EARS2
gene id: 13616:EARS2
uniprot id: F7CD53
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

13616:LOC100020427
gene id: 13616:LOC100020427
uniprot id: A0A5F8HKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:YIPF1
gene id: 13616:YIPF1
uniprot id: H9H7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

13616:FMO5
gene id: 13616:FMO5
uniprot id: F7FCD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:ACTN2
gene id: 13616:ACTN2
uniprot id: A0A5F8G362
uniprot id: F6YXB0
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:PLA2G15
gene id: 13616:PLA2G15
uniprot id: F7EQG0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

13616:BCL2A1
gene id: 13616:BCL2A1
uniprot id: F6SFL4
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:SMO
gene id: 13616:SMO
uniprot id: F7E7J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium

13616:PNPT1
gene id: 13616:PNPT1
uniprot id: F6RID9
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

13616:LOC100015860
gene id: 13616:LOC100015860
uniprot id: F7G1Y8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:ENTPD1
gene id: 13616:ENTPD1
uniprot id: A0A5F8H455
uniprot id: F7FL76
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:HOXA5
gene id: 13616:HOXA5
uniprot id: F6UA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:IMPACT
gene id: 13616:IMPACT
uniprot id: F7G2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

13616:LOC100013319
gene id: 13616:LOC100013319
uniprot id: A0A5F8HEY3
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100031295
gene id: 13616:LOC100031295
uniprot id: F6UH76
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:MRPL11
gene id: 13616:MRPL11
uniprot id: F6Z7R6
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

13616:LUC7L2
gene id: 13616:LUC7L2
uniprot id: A0A5F8GQJ6
names: Similarity
messages: Belongs to the Luc7 family.

13616:CMC2
gene id: 13616:CMC2
uniprot id: F7G3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

13616:RAB3B
gene id: 13616:RAB3B
uniprot id: A0A5F8H3C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

13616:WHAMM
gene id: 13616:WHAMM
uniprot id: F7AXA6
names: Subcellular Location Annotation
messages: Membrane

13616:TPD52L1
gene id: 13616:TPD52L1
uniprot id: A0A5F8GX98
uniprot id: A0A5F8H9E8
names: Similarity
messages: Belongs to the TPD52 family.

13616:CHAF1B
gene id: 13616:CHAF1B
uniprot id: F6RJB6
names: Subcellular Location Annotation
messages: Nucleus

13616:VPS29
gene id: 13616:VPS29
uniprot id: F6XX15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

13616:USP48
gene id: 13616:USP48
uniprot id: F7EFT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

13616:SAE1
gene id: 13616:SAE1
uniprot id: F7GCP9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

13616:AMIGO3
gene id: 13616:AMIGO3
uniprot id: F6UY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

13616:VAMP2
gene id: 13616:VAMP2
uniprot id: A0A5F8GDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:CDH1
gene id: 13616:CDH1
uniprot id: F6T0X0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:PSMA4
gene id: 13616:PSMA4
uniprot id: F7FST5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:SSTR4
gene id: 13616:SSTR4
uniprot id: A0A5F8GJ61
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:RDX
gene id: 13616:RDX
uniprot id: A0A5F8GK37
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

13616:RTBDN
gene id: 13616:RTBDN
uniprot id: K7E4M5
names: Similarity
messages: Belongs to the folate receptor family.

13616:PIGM
gene id: 13616:PIGM
uniprot id: F6USQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

13616:EMC9
gene id: 13616:EMC9
uniprot id: A0A5F8HG77
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

13616:AGPAT5
gene id: 13616:AGPAT5
uniprot id: F7G4Z7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:SGSH
gene id: 13616:SGSH
uniprot id: F7DFZ7
names: Similarity
messages: Belongs to the sulfatase family.

13616:MTO1
gene id: 13616:MTO1
uniprot id: F7GD23
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

13616:GLYATL3
gene id: 13616:GLYATL3
uniprot id: A0A5F8GQX4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

13616:CSE1L
gene id: 13616:CSE1L
uniprot id: F7BH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

13616:LOC100025565
gene id: 13616:LOC100025565
uniprot id: F7FI80
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:GATAD2A
gene id: 13616:GATAD2A
uniprot id: A0A5F8GVQ8
uniprot id: F6X9S3
names: Subcellular Location Annotation
messages: Nucleus

13616:RBM46
gene id: 13616:RBM46
uniprot id: F7BZW1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:HPSE
gene id: 13616:HPSE
uniprot id: F6RYL5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

13616:LOC100029204
gene id: 13616:LOC100029204
uniprot id: F6XCC1
names: Similarity
messages: Belongs to the BASP1 family.

13616:LIF
gene id: 13616:LIF
uniprot id: F7EE29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

13616:BNIP3L
gene id: 13616:BNIP3L
uniprot id: F6S038
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

13616:RAB11FIP3
gene id: 13616:RAB11FIP3
uniprot id: A0A5F8GJ75
uniprot id: F7E6J7
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

13616:LOC100618142
gene id: 13616:LOC100618142
uniprot id: H9H8F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:WDR46
gene id: 13616:WDR46
uniprot id: F6TQX6
names: Subcellular Location Annotation
messages: nucleolus

13616:SIX2
gene id: 13616:SIX2
uniprot id: A0A5F8HB46
names: Subcellular Location Annotation
messages: Nucleus

13616:ANTKMT
gene id: 13616:ANTKMT
uniprot id: A0A5F8GHD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

13616:TM4SF20
gene id: 13616:TM4SF20
uniprot id: F6UGK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:LHFPL2
gene id: 13616:LHFPL2
uniprot id: F6X4R7
names: Subcellular Location Annotation
messages: Membrane

13616:NRF1
gene id: 13616:NRF1
uniprot id: F6YNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

13616:LOC100010102
gene id: 13616:LOC100010102
uniprot id: F7EIN0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:NMS
gene id: 13616:NMS
uniprot id: A0A5F8G662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

13616:DDC
gene id: 13616:DDC
uniprot id: A0A5F8H514
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

13616:CHCHD6
gene id: 13616:CHCHD6
uniprot id: K7DZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

13616:ADAMTS17
gene id: 13616:ADAMTS17
uniprot id: F6TYF6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:LOC100031266
gene id: 13616:LOC100031266
uniprot id: F6RSM4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:DZIP3
gene id: 13616:DZIP3
uniprot id: A0A5F8G6N7
uniprot id: F6U2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-box family.
messages: Cytoplasm

13616:SF3A1
gene id: 13616:SF3A1
uniprot id: F7DA32
names: Subcellular Location Annotation
messages: Nucleus

13616:YOD1
gene id: 13616:YOD1
uniprot id: F6YEW2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

13616:CHPT1
gene id: 13616:CHPT1
uniprot id: F7GFA6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

13616:SLC25A33
gene id: 13616:SLC25A33
uniprot id: F6PNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:IDNK
gene id: 13616:IDNK
uniprot id: A0A5F8GF33
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

13616:LOC107651329
gene id: 13616:LOC107651329
uniprot id: F7DP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IPO5
gene id: 13616:IPO5
uniprot id: F7FFK8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:CEBPB
gene id: 13616:CEBPB
uniprot id: F7A5L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:SLC6A7
gene id: 13616:SLC6A7
uniprot id: F6XTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:GSDMB
gene id: 13616:GSDMB
uniprot id: F7GCF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

13616:GPC1
gene id: 13616:GPC1
uniprot id: F7FML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

13616:LPCAT2
gene id: 13616:LPCAT2
uniprot id: F7EVV8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:AP4B1
gene id: 13616:AP4B1
uniprot id: F6WLR5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:ZC2HC1C
gene id: 13616:ZC2HC1C
uniprot id: F6SKX5
names: Similarity
messages: Belongs to the ZC2HC1 family.

13616:LMOD1
gene id: 13616:LMOD1
uniprot id: F6Y639
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

13616:LOC100023762
gene id: 13616:LOC100023762
uniprot id: F6ZH50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP2R3C
gene id: 13616:PPP2R3C
uniprot id: F7GKQ5
names: Subcellular Location Annotation
messages: Nucleus

13616:ESF1
gene id: 13616:ESF1
uniprot id: F7ASI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

13616:ATP5PF
gene id: 13616:ATP5PF
uniprot id: F6QZT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

13616:TMEM38B
gene id: 13616:TMEM38B
uniprot id: F6YNW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

13616:monDomV1R1201
gene id: 13616:monDomV1R1201
uniprot id: A0A5F8G3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100009990
gene id: 13616:LOC100009990
uniprot id: F7DHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

13616:SLC22A2
gene id: 13616:SLC22A2
uniprot id: F6PGR8
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

13616:CLPS
gene id: 13616:CLPS
uniprot id: F6X7L4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

13616:LOC100011915
gene id: 13616:LOC100011915
uniprot id: F6ZBI1
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:PMF1
gene id: 13616:PMF1
uniprot id: F6ZUU9
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

13616:EIF2D
gene id: 13616:EIF2D
uniprot id: F6UZY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

13616:AXL
gene id: 13616:AXL
uniprot id: F6VDX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

13616:ZNF711
gene id: 13616:ZNF711
uniprot id: A0A5F8HDU1
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100012064
gene id: 13616:LOC100012064
uniprot id: K7E2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:LAMP1
gene id: 13616:LAMP1
uniprot id: F7D889
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

13616:HHIPL2
gene id: 13616:HHIPL2
uniprot id: F6TQQ8
names: Similarity
messages: Belongs to the HHIP family.

13616:AURKB
gene id: 13616:AURKB
uniprot id: A0A5F8HD14
uniprot id: F7ETI2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

13616:RPSA
gene id: 13616:RPSA
uniprot id: F7BC17
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

13616:TTC4
gene id: 13616:TTC4
uniprot id: F7D8P9
names: Similarity
messages: Belongs to the TTC4 family.

13616:RAPGEF2
gene id: 13616:RAPGEF2
uniprot id: A0A5F8G549
names: Similarity
messages: Belongs to the RAPGEF2 family.

13616:GNA13
gene id: 13616:GNA13
uniprot id: F6WQL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

13616:KDM4C
gene id: 13616:KDM4C
uniprot id: F6V4I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

13616:LOC100029431
gene id: 13616:LOC100029431
uniprot id: F7DB56
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

13616:MRPL12
gene id: 13616:MRPL12
uniprot id: F6PNJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

13616:GPAT3
gene id: 13616:GPAT3
uniprot id: F6Z9L3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:TFAP2D
gene id: 13616:TFAP2D
uniprot id: F7GKB3
names: Similarity
messages: Belongs to the AP-2 family.

13616:LSM5
gene id: 13616:LSM5
uniprot id: K7E2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

13616:IPO9
gene id: 13616:IPO9
uniprot id: F6UA59
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PXMP4
gene id: 13616:PXMP4
uniprot id: F7E2H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

13616:LOC100028676
gene id: 13616:LOC100028676
uniprot id: F7AKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024051
gene id: 13616:LOC100024051
uniprot id: F7EHY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL27A
gene id: 13616:RPL27A
uniprot id: A0A5F8GDJ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

13616:QPCT
gene id: 13616:QPCT
uniprot id: F7F2N3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

13616:ESRRG
gene id: 13616:ESRRG
uniprot id: F6QPZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

13616:NDST4
gene id: 13616:NDST4
uniprot id: F7A1T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

13616:MTMR8
gene id: 13616:MTMR8
uniprot id: H9H7A7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:ICMT
gene id: 13616:ICMT
uniprot id: A0A5F8HIQ5
uniprot id: F7AHJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LOC100021803
gene id: 13616:LOC100021803
uniprot id: F6YQL0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:AKR1B1
gene id: 13616:AKR1B1
uniprot id: K7E1G6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

13616:DOK2
gene id: 13616:DOK2
uniprot id: A0A5F8G7D3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

13616:CASP3
gene id: 13616:CASP3
uniprot id: Q2V579
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:PSMD3
gene id: 13616:PSMD3
uniprot id: F7CS51
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

13616:JUP
gene id: 13616:JUP
uniprot id: F7DNP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

13616:OSBPL2
gene id: 13616:OSBPL2
uniprot id: F7D1T6
names: Similarity
messages: Belongs to the OSBP family.

13616:TMEM255B
gene id: 13616:TMEM255B
uniprot id: A0A5F8GBG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

13616:LOC100013458
gene id: 13616:LOC100013458
uniprot id: F7GHY7
names: Similarity
messages: Belongs to the IUNH family.

13616:ASTE1
gene id: 13616:ASTE1
uniprot id: F7E008
names: Similarity
messages: Belongs to the asteroid family.

13616:MON1B
gene id: 13616:MON1B
uniprot id: F6YR92
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

13616:VEGFD
gene id: 13616:VEGFD
uniprot id: F6WHL4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:CLDN18
gene id: 13616:CLDN18
uniprot id: F7GCU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

13616:DNASE1L3
gene id: 13616:DNASE1L3
uniprot id: F7CVX4
names: Similarity
messages: Belongs to the DNase I family.

13616:SBDS
gene id: 13616:SBDS
uniprot id: F7G494
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

13616:TINAG
gene id: 13616:TINAG
uniprot id: F6ZNT2
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:CLUAP1
gene id: 13616:CLUAP1
uniprot id: F7ASW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

13616:DUSP1
gene id: 13616:DUSP1
uniprot id: A0A5F8H9X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

13616:TPM3
gene id: 13616:TPM3
uniprot id: A0A5F8G2V4
uniprot id: A0A5F8GB96
uniprot id: A0A5F8GU92
uniprot id: A0A5F8HJ31
uniprot id: F6TK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

13616:HPGD
gene id: 13616:HPGD
uniprot id: A0A5F8G5J7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:DMRTC2
gene id: 13616:DMRTC2
uniprot id: H9H6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:KIF25
gene id: 13616:KIF25
uniprot id: A0A5F8H1C2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:TAS2R60
gene id: 13616:TAS2R60
uniprot id: Q2AB85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:EXOC3
gene id: 13616:EXOC3
uniprot id: F6SBJ3
names: Similarity
messages: Belongs to the SEC6 family.

13616:RIMKLA
gene id: 13616:RIMKLA
uniprot id: F6XCL7
names: Similarity
messages: Belongs to the RimK family.

13616:LOC100019538
gene id: 13616:LOC100019538
uniprot id: A0A5F8GNZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

13616:TMEM45A
gene id: 13616:TMEM45A
uniprot id: F6UIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

13616:LOC100023238
gene id: 13616:LOC100023238
uniprot id: F7EAX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MINDY3
gene id: 13616:MINDY3
uniprot id: F6TUG9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

13616:TRIM45
gene id: 13616:TRIM45
uniprot id: A0A5F8GEA8
uniprot id: A0A5F8H696
uniprot id: F7E8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

13616:EIF1AD
gene id: 13616:EIF1AD
uniprot id: F7G2D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

13616:TMEM35B
gene id: 13616:TMEM35B
uniprot id: K7E0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

13616:NR1H4
gene id: 13616:NR1H4
uniprot id: A0A5F8HHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:HLF
gene id: 13616:HLF
uniprot id: F7BZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

13616:SEC13
gene id: 13616:SEC13
uniprot id: F7GFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

13616:PAPPA2
gene id: 13616:PAPPA2
uniprot id: F7CFD6
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100030396
gene id: 13616:LOC100030396
uniprot id: F7AP39
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

13616:LOC100027544
gene id: 13616:LOC100027544
uniprot id: F6XE08
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

13616:ACTL6B
gene id: 13616:ACTL6B
uniprot id: F6QIK5
names: Similarity
messages: Belongs to the actin family.

13616:T2R7A
gene id: 13616:T2R7A
uniprot id: Q2ABA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:TMEM18
gene id: 13616:TMEM18
uniprot id: F6X0K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

13616:MND1
gene id: 13616:MND1
uniprot id: F7D4R4
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC25A3
gene id: 13616:SLC25A3
uniprot id: A0A5F8H0C3
uniprot id: F6SW34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

13616:CHUK
gene id: 13616:CHUK
uniprot id: F6YS11
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:SMC3
gene id: 13616:SMC3
uniprot id: A0A5F8G848
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

13616:MMP16
gene id: 13616:MMP16
uniprot id: F7G8Z6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:SULT6B1
gene id: 13616:SULT6B1
uniprot id: F6TLW8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:VIPR2
gene id: 13616:VIPR2
uniprot id: F7CG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

13616:LOC100009916
gene id: 13616:LOC100009916
uniprot id: F6VTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

13616:CREBL2
gene id: 13616:CREBL2
uniprot id: A0A5F8GBD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

13616:CCNG1
gene id: 13616:CCNG1
uniprot id: A0A5F8G212
names: Similarity
messages: Belongs to the cyclin family.

13616:CSRNP3
gene id: 13616:CSRNP3
uniprot id: A0A5F8G8G9
uniprot id: A0A5F8GW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

13616:LOC100011313
gene id: 13616:LOC100011313
uniprot id: F7DIB7
names: Similarity
messages: Belongs to the actin family.

13616:KRR1
gene id: 13616:KRR1
uniprot id: F7A3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

13616:UPF2
gene id: 13616:UPF2
uniprot id: F7G5X8
names: Subcellular Location Annotation
messages: Cytoplasm

13616:ID1
gene id: 13616:ID1
uniprot id: F6W9Y6
names: Subcellular Location Annotation
messages: Nucleus

13616:FHIP2A
gene id: 13616:FHIP2A
uniprot id: F6XT73
names: Similarity
messages: Belongs to the FHIP family.

13616:FAM187A
gene id: 13616:FAM187A
uniprot id: F7D3V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

13616:C4BPA
gene id: 13616:C4BPA
uniprot id: A0A5F8GCZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100018015
gene id: 13616:LOC100018015
uniprot id: F6QMG1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

13616:EFNB2
gene id: 13616:EFNB2
uniprot id: A0A5F8HI99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CMKLR2
gene id: 13616:CMKLR2
uniprot id: A0A5F8GQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

13616:PES1
gene id: 13616:PES1
uniprot id: F6QKJ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

13616:BRPF1
gene id: 13616:BRPF1
uniprot id: F7A3V4
names: Subcellular Location Annotation
messages: Nucleus

13616:PLA2G4E
gene id: 13616:PLA2G4E
uniprot id: A0A5F8GD10
uniprot id: F7E3Q7
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

13616:MMUT
gene id: 13616:MMUT
uniprot id: F7DW04
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

13616:LOC100020912
gene id: 13616:LOC100020912
uniprot id: A0A5F8G1U1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:LOC100023248
gene id: 13616:LOC100023248
uniprot id: A0A5F8HBU8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

13616:PABPC4
gene id: 13616:PABPC4
uniprot id: F6YJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

13616:SHROOM4
gene id: 13616:SHROOM4
uniprot id: F7BBG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

13616:LOC100017048
gene id: 13616:LOC100017048
uniprot id: F7FJK8
names: Similarity
messages: Belongs to the peptidase A1 family.

13616:ACER1
gene id: 13616:ACER1
uniprot id: F6W146
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CDH7
gene id: 13616:CDH7
uniprot id: F7CBX9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:SLC39A10
gene id: 13616:SLC39A10
uniprot id: F7ALF5
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100011118
gene id: 13616:LOC100011118
uniprot id: F6PXT9
names: Similarity
messages: Belongs to the TTC39 family.

13616:LOC100019992
gene id: 13616:LOC100019992
uniprot id: A0A5F8HAC6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

13616:RIDA
gene id: 13616:RIDA
uniprot id: F7B859
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

13616:LOC100027795
gene id: 13616:LOC100027795
uniprot id: F7G8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GPATCH1
gene id: 13616:GPATCH1
uniprot id: F6Z6Q3
names: Similarity
messages: Belongs to the GPATCH1 family.

13616:GJD4
gene id: 13616:GJD4
uniprot id: A0A5F8GLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:SEBOX
gene id: 13616:SEBOX
uniprot id: A0A5F8HEM7
names: Subcellular Location Annotation
messages: Nucleus

13616:ZP1
gene id: 13616:ZP1
uniprot id: F6WXF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100026625
gene id: 13616:LOC100026625
uniprot id: F6TKJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

13616:MEIG1
gene id: 13616:MEIG1
uniprot id: A0A5F8GMA0
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

13616:IDH3A
gene id: 13616:IDH3A
uniprot id: F6TJ83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

13616:CD14
gene id: 13616:CD14
uniprot id: F6SDH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

13616:STOM
gene id: 13616:STOM
uniprot id: A0A5F8GY80
uniprot id: F6UAH2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

13616:CES2.1
gene id: 13616:CES2.1
uniprot id: B2BSF5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

13616:NF2
gene id: 13616:NF2
uniprot id: A0A5F8H1A1
uniprot id: F7GLA2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

13616:TNKS
gene id: 13616:TNKS
uniprot id: A0A5F8GUB1
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:TYRP1
gene id: 13616:TYRP1
uniprot id: F7FUN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

13616:DAD1
gene id: 13616:DAD1
uniprot id: F7CZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:PGF
gene id: 13616:PGF
uniprot id: F7FF03
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:DMRTA1
gene id: 13616:DMRTA1
uniprot id: F7GJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:EIF3E
gene id: 13616:EIF3E
uniprot id: F6ZC02
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

13616:VN2R583
gene id: 13616:VN2R583
uniprot id: A0A5F8GN55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:HMGB3
gene id: 13616:HMGB3
uniprot id: C7E652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

13616:STARD3
gene id: 13616:STARD3
uniprot id: F7DZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:ACTL7B
gene id: 13616:ACTL7B
uniprot id: F6XB87
names: Similarity
messages: Belongs to the actin family.

13616:TRNT1
gene id: 13616:TRNT1
uniprot id: F6W967
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

13616:GRB10
gene id: 13616:GRB10
uniprot id: F6YZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

13616:TMEM98
gene id: 13616:TMEM98
uniprot id: A0A5F8HIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

13616:OXT
gene id: 13616:OXT
uniprot id: F7D0I5
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:HDAC5
gene id: 13616:HDAC5
uniprot id: A0A5F8GB78
uniprot id: F7G734
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

13616:ZC3H12C
gene id: 13616:ZC3H12C
uniprot id: A0A5F8GYA3
uniprot id: F7E8N8
names: Similarity
messages: Belongs to the ZC3H12 family.

13616:LOC100024418
gene id: 13616:LOC100024418
uniprot id: F6VJ03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

13616:SLCO1A2
gene id: 13616:SLCO1A2
uniprot id: F6ZXK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:HOMER3
gene id: 13616:HOMER3
uniprot id: F7AAG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

13616:MEGF9
gene id: 13616:MEGF9
uniprot id: F6XPU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SLC25A40
gene id: 13616:SLC25A40
uniprot id: A0A5F8G986
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

13616:ITGB3BP
gene id: 13616:ITGB3BP
uniprot id: A0A5F8G4M0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

13616:DUS4L
gene id: 13616:DUS4L
uniprot id: F7F6S4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

13616:LOC100013827
gene id: 13616:LOC100013827
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:TOP3B
gene id: 13616:TOP3B
uniprot id: F7FUS9
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

13616:LOC100021807
gene id: 13616:LOC100021807
uniprot id: F6X027
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HTRA3
gene id: 13616:HTRA3
uniprot id: F6ZXS4
names: Similarity
messages: Belongs to the peptidase S1C family.

13616:ADAMTS15
gene id: 13616:ADAMTS15
uniprot id: F7E8C6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:DNAH7
gene id: 13616:DNAH7
uniprot id: F7FU84
names: Similarity
messages: Belongs to the dynein heavy chain family.

13616:LOC100022501
gene id: 13616:LOC100022501
uniprot id: F6RT32
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

13616:ETV4
gene id: 13616:ETV4
uniprot id: F7BW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:TMEM245
gene id: 13616:TMEM245
uniprot id: A0A5F8GGL3
uniprot id: F6PLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

13616:IWS1
gene id: 13616:IWS1
uniprot id: F7AEQ1
names: Subcellular Location Annotation
messages: Nucleus

13616:CD8A
gene id: 13616:CD8A
uniprot id: I6LJ10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100022188
gene id: 13616:LOC100022188
uniprot id: A0A5F8GGM0
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

13616:RPS6KA2
gene id: 13616:RPS6KA2
uniprot id: A0A5F8GFF9
uniprot id: F7FRY0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:CLDN7
gene id: 13616:CLDN7
uniprot id: F6ZWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:TACC3
gene id: 13616:TACC3
uniprot id: A0A5F8G3I6
uniprot id: F6TDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

13616:GABRA3
gene id: 13616:GABRA3
uniprot id: F6S4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:SLC23A3
gene id: 13616:SLC23A3
uniprot id: F6XFG6
names: Subcellular Location Annotation
messages: Membrane

13616:NTRK3
gene id: 13616:NTRK3
uniprot id: A0A5F8GYP0
uniprot id: F7FCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

13616:VN2R510
gene id: 13616:VN2R510
uniprot id: F7A727
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ETV6
gene id: 13616:ETV6
uniprot id: F6PG63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:KCTD20
gene id: 13616:KCTD20
uniprot id: F7C3E1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:AP3D1
gene id: 13616:AP3D1
uniprot id: A0A5F8H916
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:VTI1A
gene id: 13616:VTI1A
uniprot id: F6TAL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

13616:TMEM17
gene id: 13616:TMEM17
uniprot id: F6PQE0
names: Subcellular Location Annotation
messages: Membrane

13616:PCNA
gene id: 13616:PCNA
uniprot id: F6TIM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

13616:LOC100617205
gene id: 13616:LOC100617205
uniprot id: A0A5F8G1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HIKESHI
gene id: 13616:HIKESHI
uniprot id: A0A5F8GB63
uniprot id: A0A5F8GNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

13616:RHBDD3
gene id: 13616:RHBDD3
uniprot id: F6PH35
names: Subcellular Location Annotation
messages: Membrane

13616:CERS2
gene id: 13616:CERS2
uniprot id: F6YYM6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:FAM124A
gene id: 13616:FAM124A
uniprot id: F7G7F7
names: Similarity
messages: Belongs to the FAM124 family.

13616:LOC100015520
gene id: 13616:LOC100015520
uniprot id: A0A5F8GB15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:LOC100618096
gene id: 13616:LOC100618096
uniprot id: F7D2A4
names: Subcellular Location Annotation
messages: Membrane

13616:RPL22
gene id: 13616:RPL22
uniprot id: A0A5F8H0Y1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

13616:ADAM22
gene id: 13616:ADAM22
uniprot id: A0A5F8GL95
uniprot id: F6S926
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VARS2
gene id: 13616:VARS2
uniprot id: F7F0F7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:VN2R519
gene id: 13616:VN2R519
uniprot id: F6ZLJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:EMC7
gene id: 13616:EMC7
uniprot id: F6T7N4
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

13616:GLOD4
gene id: 13616:GLOD4
uniprot id: F7D817
names: Similarity
messages: Belongs to the glyoxalase I family.

13616:BAK1
gene id: 13616:BAK1
uniprot id: F6R4F6
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:GTF2H4
gene id: 13616:GTF2H4
uniprot id: F7F0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

13616:SLC47A2
gene id: 13616:SLC47A2
uniprot id: F7APY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

13616:LOC100017577
gene id: 13616:LOC100017577
uniprot id: F6T305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

13616:MARCO
gene id: 13616:MARCO
uniprot id: F6UT87
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:CLDN17
gene id: 13616:CLDN17
uniprot id: F6ZAA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:monDomV1R1238
gene id: 13616:monDomV1R1238
uniprot id: A0A5F8H815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC7A6OS
gene id: 13616:SLC7A6OS
uniprot id: F6YQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

13616:SNRPF
gene id: 13616:SNRPF
uniprot id: F7GFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

13616:FBXO25
gene id: 13616:FBXO25
uniprot id: A0A5F8HHB7
names: Subcellular Location Annotation
messages: Nucleus

13616:PRMT7
gene id: 13616:PRMT7
uniprot id: A0A5F8H4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

13616:RTN1
gene id: 13616:RTN1
uniprot id: A0A5F8GG39
uniprot id: F7GF19
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100619160
gene id: 13616:LOC100619160
uniprot id: A0A5F8H995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FAM83A
gene id: 13616:FAM83A
uniprot id: F6QBX8
names: Similarity
messages: Belongs to the FAM83 family.

13616:MANBA
gene id: 13616:MANBA
uniprot id: A0A5F8G3D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

13616:HS3ST5
gene id: 13616:HS3ST5
uniprot id: A0A5F8G6D9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:MRPL50
gene id: 13616:MRPL50
uniprot id: F6RH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

13616:DRC1
gene id: 13616:DRC1
uniprot id: F7FS23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

13616:GMPR2
gene id: 13616:GMPR2
uniprot id: F6THE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

13616:UTP11
gene id: 13616:UTP11
uniprot id: F7FHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

13616:LOC100020439
gene id: 13616:LOC100020439
uniprot id: F6TUR3
names: Similarity
messages: Belongs to the actin family.

13616:LOC100023593
gene id: 13616:LOC100023593
uniprot id: F7E0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100619446
gene id: 13616:LOC100619446
uniprot id: F7D289
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

13616:PPT1
gene id: 13616:PPT1
uniprot id: F6Z4J7
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

13616:CRELD1
gene id: 13616:CRELD1
uniprot id: F6YLH8
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:THAP10
gene id: 13616:THAP10
uniprot id: F7B334
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

13616:LOC100022920
gene id: 13616:LOC100022920
uniprot id: F6YEC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:LOC100616863
gene id: 13616:LOC100616863
uniprot id: F7G8I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100617842
gene id: 13616:LOC100617842
uniprot id: F7ASG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TP53I11
gene id: 13616:TP53I11
uniprot id: F6RQR2
names: Subcellular Location Annotation
messages: Membrane

13616:NID1
gene id: 13616:NID1
uniprot id: F7FV41
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

13616:LOC100022327
gene id: 13616:LOC100022327
uniprot id: F7B5I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100027512
gene id: 13616:LOC100027512
uniprot id: F6WFL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MED30
gene id: 13616:MED30
uniprot id: F6VFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

13616:SMOC1
gene id: 13616:SMOC1
uniprot id: F6VWV4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GALNT14
gene id: 13616:GALNT14
uniprot id: A0A5F8GTV4
uniprot id: F6VYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:NUP188
gene id: 13616:NUP188
uniprot id: F7GEX1
names: Subcellular Location Annotation
messages: nuclear pore complex

13616:SDF4
gene id: 13616:SDF4
uniprot id: F7A470
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

13616:TSNAX
gene id: 13616:TSNAX
uniprot id: A0A5F8GGL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

13616:HTR2B
gene id: 13616:HTR2B
uniprot id: F7G7L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

13616:CAP2
gene id: 13616:CAP2
uniprot id: F7F511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

13616:CCNB1
gene id: 13616:CCNB1
uniprot id: F6TCH9
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

13616:LOC100022035
gene id: 13616:LOC100022035
uniprot id: F7B4P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100618560
gene id: 13616:LOC100618560
uniprot id: A0A5F8GXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ST7L
gene id: 13616:ST7L
uniprot id: A0A5F8G2J3
uniprot id: A0A5F8G6G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

13616:HOXA11
gene id: 13616:HOXA11
uniprot id: F6USH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:SERPINE2
gene id: 13616:SERPINE2
uniprot id: A0A5F8HDU4
names: Similarity
messages: Belongs to the serpin family.

13616:ACAP2
gene id: 13616:ACAP2
uniprot id: A0A5F8GCE3
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

13616:SDHAF3
gene id: 13616:SDHAF3
uniprot id: H9H6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

13616:VN2R610
gene id: 13616:VN2R610
uniprot id: F6VJW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ID2
gene id: 13616:ID2
uniprot id: F6ZDF6
names: Subcellular Location Annotation
messages: Nucleus

13616:AGPAT2
gene id: 13616:AGPAT2
uniprot id: F7AHW4
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

13616:HGS
gene id: 13616:HGS
uniprot id: A0A5F8H1Z0
uniprot id: F7EJJ9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

13616:SLC27A1
gene id: 13616:SLC27A1
uniprot id: F6SCF1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:CLIP1
gene id: 13616:CLIP1
uniprot id: A0A5F8GDT4
uniprot id: A0A5F8HES8
uniprot id: F6YGW0
names: Subcellular Location Annotation
messages: cytoskeleton

13616:XKR5
gene id: 13616:XKR5
uniprot id: F7FM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

13616:NXPH1
gene id: 13616:NXPH1
uniprot id: A0A5F8GUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

13616:SLC27A3
gene id: 13616:SLC27A3
uniprot id: F6WFG8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:SLC22A4
gene id: 13616:SLC22A4
uniprot id: F6R601
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

13616:ODF1
gene id: 13616:ODF1
uniprot id: F6XD73
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

13616:MRPS11
gene id: 13616:MRPS11
uniprot id: F6Y8U7
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

13616:TEKT3
gene id: 13616:TEKT3
uniprot id: F7FNQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

13616:LOC100019935
gene id: 13616:LOC100019935
uniprot id: A0A5F8GK22
names: Similarity
messages: Belongs to the acylphosphatase family.

13616:LSM3
gene id: 13616:LSM3
uniprot id: K7E291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

13616:PPM1K
gene id: 13616:PPM1K
uniprot id: F6QTI3
names: Similarity
messages: Belongs to the PP2C family.

13616:LOC100028022
gene id: 13616:LOC100028022
uniprot id: A0A5F8GCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLA
gene id: 13616:SLA
uniprot id: F7CJV5
names: Subcellular Location Annotation
messages: Cytoplasm

13616:AGPAT4
gene id: 13616:AGPAT4
uniprot id: F7CDG3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:GTPBP4
gene id: 13616:GTPBP4
uniprot id: F6TMC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

13616:NFKB1
gene id: 13616:NFKB1
uniprot id: F7DLB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:ARSB
gene id: 13616:ARSB
uniprot id: F6X4S3
names: Similarity
messages: Belongs to the sulfatase family.

13616:RIC8B
gene id: 13616:RIC8B
uniprot id: F7AMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

13616:T2R7B
gene id: 13616:T2R7B
uniprot id: Q2AB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:PLA2G1B
gene id: 13616:PLA2G1B
uniprot id: F6VFV8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

13616:CD4
gene id: 13616:CD4
uniprot id: A6MAP0
names: Subcellular Location Annotation
messages: Cell membrane

13616:LOC100020096
gene id: 13616:LOC100020096
uniprot id: F7BM51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

13616:LOC100027752
gene id: 13616:LOC100027752
uniprot id: F7EG90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.
messages: Secreted

13616:RPS6
gene id: 13616:RPS6
uniprot id: F6VVN3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

13616:PSMB9
gene id: 13616:PSMB9
uniprot id: A0A5F8GR45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:MRGBP
gene id: 13616:MRGBP
uniprot id: F7FVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

13616:STRA6
gene id: 13616:STRA6
uniprot id: A0A5F8GED7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TLR6
gene id: 13616:TLR6
uniprot id: F7ENG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

13616:CSTB
gene id: 13616:CSTB
uniprot id: F6W0H8
names: Similarity
messages: Belongs to the cystatin family.

13616:LOC100017013
gene id: 13616:LOC100017013
uniprot id: F6YZG1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

13616:FGF2
gene id: 13616:FGF2
uniprot id: P48798
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro. Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3. Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling. Interacts with SNORC (via the extracellular domain). Interacts with glypican GPC3.
messages: Nucleus
messages: Phosphorylation at Tyr-83 regulates FGF2 unconventional secretion.
messages: Secreted

13616:RAB3C
gene id: 13616:RAB3C
uniprot id: A0A5F8GNN1
uniprot id: F6R8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

13616:FAM83B
gene id: 13616:FAM83B
uniprot id: A0A5F8G730
names: Similarity
messages: Belongs to the FAM83 family.

13616:ERGIC2
gene id: 13616:ERGIC2
uniprot id: A0A5F8GQG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

13616:SLC6A19
gene id: 13616:SLC6A19
uniprot id: F7A6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:TACR1
gene id: 13616:TACR1
uniprot id: F6X011
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

13616:LOC100026632
gene id: 13616:LOC100026632
uniprot id: F7AJ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

13616:RPS2
gene id: 13616:RPS2
uniprot id: F7G9G8
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

13616:HNRNPC
gene id: 13616:HNRNPC
uniprot id: A0A5F8GVE6
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

13616:PKD1
gene id: 13616:PKD1
uniprot id: F6YV18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PDGFRA
gene id: 13616:PDGFRA
uniprot id: F7E5I9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

13616:CDKN2A
gene id: 13616:CDKN2A
uniprot id: O77617
uniprot id: O77618
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).
messages: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
messages: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
messages: Cytoplasm
messages: Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53. Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (By similarity). Interacts with TTF1 (via the N-terminal region (NRD) and a C-terminal region); the interaction is direct and inhibits the nucleolar localization of TTF1 (By similarity).
messages: Expressed predominantly in lung and testis. In the testis, restricted to germ cells in the seminiferous epithelium. Not detected in premeiotic spermatogonia but high levels found in postmeiotic spermatids. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.
messages: Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 (By similarity).
messages: Nucleus
messages: Produced by alternative initiation at Met-35 of isoform 1.
messages: The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to cyclin-dependent kinase inhibitor 2A (AC O77617) which is encoded by the same gene.
messages: The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC O77618) which is encoded by the same gene.
messages: Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.
messages: Ubiquitously expressed. In the testis, expressed in both somatic and germ cells. Not detected in premeiotic spermatogonia but expressed in both meiotic and postmeiotic cells. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.
messages: nucleolus
messages: nucleoplasm

13616:BMPR2
gene id: 13616:BMPR2
uniprot id: F7AU53
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

13616:BROX
gene id: 13616:BROX
uniprot id: F6V683
names: Similarity
messages: Belongs to the BROX family.

13616:GUCA2B
gene id: 13616:GUCA2B
uniprot id: F6WWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

13616:STAG2
gene id: 13616:STAG2
uniprot id: F6ZBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

13616:LOC100617961
gene id: 13616:LOC100617961
uniprot id: F7BCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC100020618
gene id: 13616:LOC100020618
uniprot id: F7G6I0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

13616:LOC100016977
gene id: 13616:LOC100016977
uniprot id: F6ZTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CPSF7
gene id: 13616:CPSF7
uniprot id: A0A5F8GG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

13616:SNCG
gene id: 13616:SNCG
uniprot id: A0A5F8HL03
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

13616:TRMT11
gene id: 13616:TRMT11
uniprot id: F7GFQ3
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

13616:CALR
gene id: 13616:CALR
uniprot id: F6QXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

13616:CDK20
gene id: 13616:CDK20
uniprot id: F6XM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

13616:LOC100027984
gene id: 13616:LOC100027984
uniprot id: F6PRJ7
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

13616:KHDC4
gene id: 13616:KHDC4
uniprot id: F6UL87
names: Similarity
messages: Belongs to the KHDC4 family.

13616:MESD
gene id: 13616:MESD
uniprot id: F6SZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

13616:RASSF5
gene id: 13616:RASSF5
uniprot id: F6QW39
names: Subcellular Location Annotation
messages: cytoskeleton

13616:XPNPEP2
gene id: 13616:XPNPEP2
uniprot id: F7EVW3
names: Similarity
messages: Belongs to the peptidase M24B family.

13616:ZBED4
gene id: 13616:ZBED4
uniprot id: F6VLV3
names: Subcellular Location Annotation
messages: Nucleus

13616:SF3B4
gene id: 13616:SF3B4
uniprot id: F7DXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

13616:IRF4
gene id: 13616:IRF4
uniprot id: F7CDR0
names: Subcellular Location Annotation
messages: Nucleus

13616:CDC42SE1
gene id: 13616:CDC42SE1
uniprot id: F7GKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

13616:ELF1
gene id: 13616:ELF1
uniprot id: A0A5F8GQG3
uniprot id: F6YMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:NTS
gene id: 13616:NTS
uniprot id: A0A5F8HD06
uniprot id: F7F526
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

13616:SDHC
gene id: 13616:SDHC
uniprot id: F7EQW5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

13616:NR1D2
gene id: 13616:NR1D2
uniprot id: F7GGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:TMEM19
gene id: 13616:TMEM19
uniprot id: A0A5F8GVD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

13616:HYAL4
gene id: 13616:HYAL4
uniprot id: F6WHI3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:TMTC4
gene id: 13616:TMTC4
uniprot id: A0A5F8GCP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

13616:ECRG4
gene id: 13616:ECRG4
uniprot id: F7G527
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

13616:PLPP4
gene id: 13616:PLPP4
uniprot id: F6PGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:A2M
gene id: 13616:A2M
uniprot id: F7B8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

13616:NOB1
gene id: 13616:NOB1
uniprot id: F7CYX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

13616:TET2
gene id: 13616:TET2
uniprot id: F7FXD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

13616:EREG
gene id: 13616:EREG
uniprot id: F7A8Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GTF2H2
gene id: 13616:GTF2H2
uniprot id: F7BD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

13616:ATP6AP1
gene id: 13616:ATP6AP1
uniprot id: F7CAZ5
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

13616:TOLLIP
gene id: 13616:TOLLIP
uniprot id: A0A5F8HK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

13616:LOC100017283
gene id: 13616:LOC100017283
uniprot id: F6TJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:LOC100032740
gene id: 13616:LOC100032740
uniprot id: F6W9F0
names: Function
messages: May be involved in transcriptional regulation.

13616:HTRA2
gene id: 13616:HTRA2
uniprot id: A0A5F8GT06
names: Similarity
messages: Belongs to the peptidase S1C family.

13616:LOC100015937
gene id: 13616:LOC100015937
uniprot id: F6Z372
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:FAM72A
gene id: 13616:FAM72A
uniprot id: F6RIT0
names: Similarity
messages: Belongs to the FAM72 family.

13616:ST6GAL2
gene id: 13616:ST6GAL2
uniprot id: E4ZFH5
uniprot id: F7G4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:MRPL35
gene id: 13616:MRPL35
uniprot id: F7CPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

13616:MBOAT7
gene id: 13616:MBOAT7
uniprot id: F7D7G7
names: Subcellular Location Annotation
messages: Membrane

13616:SLC2A2
gene id: 13616:SLC2A2
uniprot id: F6ZHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

13616:POLH
gene id: 13616:POLH
uniprot id: F7G0E4
names: Subcellular Location Annotation
messages: Nucleus

13616:CDH8
gene id: 13616:CDH8
uniprot id: F7EXZ6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:MEF2B
gene id: 13616:MEF2B
uniprot id: F6VEY3
names: Subcellular Location Annotation
messages: Nucleus

13616:KPNA6
gene id: 13616:KPNA6
uniprot id: A0A5F8GFC7
uniprot id: F7E1F4
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:FGF14
gene id: 13616:FGF14
uniprot id: A0A5F8HBK8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:LOC100030002
gene id: 13616:LOC100030002
uniprot id: A0A5F8H7Q2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NEXMIF
gene id: 13616:NEXMIF
uniprot id: A0A5F8GEP1
names: Subcellular Location Annotation
messages: Nucleus

13616:TSEN15
gene id: 13616:TSEN15
uniprot id: A0A5F8GK87
names: Similarity
messages: Belongs to the SEN15 family.

13616:C7
gene id: 13616:C7
uniprot id: F7BFI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:GLG1
gene id: 13616:GLG1
uniprot id: A0A5F8H2J2
uniprot id: F6YPR6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

13616:CSTF3
gene id: 13616:CSTF3
uniprot id: F6X9G6
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103101397
gene id: 13616:LOC103101397
uniprot id: A0A5F8G4H5
names: Similarity
messages: Belongs to the TMEM176 family.

13616:SOSTDC1
gene id: 13616:SOSTDC1
uniprot id: F7BAK0
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PDX1
gene id: 13616:PDX1
uniprot id: F7BPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:RGMB
gene id: 13616:RGMB
uniprot id: F6YFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

13616:HYCC1
gene id: 13616:HYCC1
uniprot id: A0A5F8HH95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

13616:PRNP
gene id: 13616:PRNP
uniprot id: I7KJS6
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.

13616:ADRA1A
gene id: 13616:ADRA1A
uniprot id: F7E6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

13616:GJA3
gene id: 13616:GJA3
uniprot id: F7G5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:PLPPR1
gene id: 13616:PLPPR1
uniprot id: F6SRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:RPL37A
gene id: 13616:RPL37A
uniprot id: A0A5F8GQ95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

13616:PRRC1
gene id: 13616:PRRC1
uniprot id: A0A5F8GKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

13616:GBA1
gene id: 13616:GBA1
uniprot id: F6VKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

13616:VGLL3
gene id: 13616:VGLL3
uniprot id: F6VMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

13616:LOC100016989
gene id: 13616:LOC100016989
uniprot id: F6WH69
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:NUDT19
gene id: 13616:NUDT19
uniprot id: A0A5F8GUK1
uniprot id: A0A5F8HE42
names: Similarity
messages: Belongs to the Nudix hydrolase family.

13616:YIPF6
gene id: 13616:YIPF6
uniprot id: A0A5F8GZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:PAH
gene id: 13616:PAH
uniprot id: A0A5F8GPC2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

13616:SBNO2
gene id: 13616:SBNO2
uniprot id: A0A5F8GXV2
uniprot id: A0A5F8HHS8
names: Similarity
messages: Belongs to the SBNO family.

13616:SIX5
gene id: 13616:SIX5
uniprot id: A0A5F8GNT6
names: Subcellular Location Annotation
messages: Nucleus

13616:MARCHF9
gene id: 13616:MARCHF9
uniprot id: H9H7Y9
names: Subcellular Location Annotation
messages: Membrane

13616:DDIAS
gene id: 13616:DDIAS
uniprot id: F6V938
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

13616:SGK3
gene id: 13616:SGK3
uniprot id: F7GIB9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

13616:LOC100015541
gene id: 13616:LOC100015541
uniprot id: A0A5F8G408
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ABCC4
gene id: 13616:ABCC4
uniprot id: F7GJY4
names: Subcellular Location Annotation
messages: Membrane

13616:YES1
gene id: 13616:YES1
uniprot id: F7G374
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:UBA3
gene id: 13616:UBA3
uniprot id: A0A5F8G4W2
uniprot id: F7BMV0
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

13616:ANAPC5
gene id: 13616:ANAPC5
uniprot id: F7ALY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

13616:SLC26A11
gene id: 13616:SLC26A11
uniprot id: A0A5F8GUQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

13616:BUD13
gene id: 13616:BUD13
uniprot id: A0A5F8GCJ7
names: Similarity
messages: Belongs to the CWC26 family.

13616:TNFRSF1A
gene id: 13616:TNFRSF1A
uniprot id: F7G4G9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:LEP
gene id: 13616:LEP
uniprot id: A0A5F8GBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

13616:NXPE3
gene id: 13616:NXPE3
uniprot id: A0A5F8GH75
names: Similarity
messages: Belongs to the NXPE family.

13616:TAGLN2
gene id: 13616:TAGLN2
uniprot id: A0A5F8GEV2
names: Similarity
messages: Belongs to the calponin family.

13616:ENTPD6
gene id: 13616:ENTPD6
uniprot id: F7GCQ3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:C1S
gene id: 13616:C1S
uniprot id: F7CCG9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CCNYL1
gene id: 13616:CCNYL1
uniprot id: A0A5F8GSK8
uniprot id: F7FRS8
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

13616:TMEFF2
gene id: 13616:TMEFF2
uniprot id: F7EGL9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100010569
gene id: 13616:LOC100010569
uniprot id: A0A5F8GCI9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

13616:KATNA1
gene id: 13616:KATNA1
uniprot id: A0A5F8G8H7
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

13616:MCM9
gene id: 13616:MCM9
uniprot id: F7CZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

13616:MEMO1
gene id: 13616:MEMO1
uniprot id: A0A5F8GE80
names: Similarity
messages: Belongs to the MEMO1 family.

13616:ACTN4
gene id: 13616:ACTN4
uniprot id: A0A5F8GFJ7
uniprot id: A0A5F8GZK7
uniprot id: A0A5F8H0X0
uniprot id: F7DTH8
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:BST1
gene id: 13616:BST1
uniprot id: F6ZFG5
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

13616:GPR119
gene id: 13616:GPR119
uniprot id: H9H7G7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MYO6
gene id: 13616:MYO6
uniprot id: F7BRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus
messages: ruffle membrane
messages: trans-Golgi network membrane

13616:OXCT1
gene id: 13616:OXCT1
uniprot id: F7C0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

13616:MAP3K6
gene id: 13616:MAP3K6
uniprot id: F6ZG40
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:DCLRE1B
gene id: 13616:DCLRE1B
uniprot id: F6X212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

13616:MCUR1
gene id: 13616:MCUR1
uniprot id: A0A5F8GLK7
uniprot id: A0A5F8GLY0
names: Similarity
messages: Belongs to the CCDC90 family.

13616:SLC25A35
gene id: 13616:SLC25A35
uniprot id: F7E9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:ZDHHC12
gene id: 13616:ZDHHC12
uniprot id: F6TT20
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:TFB1M
gene id: 13616:TFB1M
uniprot id: A0A5F8H1J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

13616:ALAD
gene id: 13616:ALAD
uniprot id: F6SVR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

13616:LOC100031088
gene id: 13616:LOC100031088
uniprot id: A0A5F8GQ73
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

13616:LOC100616991
gene id: 13616:LOC100616991
uniprot id: F7D5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100025055
gene id: 13616:LOC100025055
uniprot id: F7GIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARCN1
gene id: 13616:ARCN1
uniprot id: A0A5F8HL90
uniprot id: F7GIN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:SPAG7
gene id: 13616:SPAG7
uniprot id: F6YNM5
names: Subcellular Location Annotation
messages: Nucleus

13616:PAQR8
gene id: 13616:PAQR8
uniprot id: F6Z2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:LOC100018887
gene id: 13616:LOC100018887
uniprot id: F6PM94
names: Similarity
messages: Belongs to the intercrine gamma family.

13616:HRH2
gene id: 13616:HRH2
uniprot id: A0A5F8H2U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100012494
gene id: 13616:LOC100012494
uniprot id: F6T5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:STEAP3
gene id: 13616:STEAP3
uniprot id: F6QMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

13616:TAGLN3
gene id: 13616:TAGLN3
uniprot id: F7FFS3
names: Similarity
messages: Belongs to the calponin family.

13616:LOC100618060
gene id: 13616:LOC100618060
uniprot id: F7GIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HRH3
gene id: 13616:HRH3
uniprot id: F7D2C8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:METTL1
gene id: 13616:METTL1
uniprot id: H9H7Z1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-32 inactivates its catalytic activity but does not affect the interaction with WDR4.

13616:NHERF1
gene id: 13616:NHERF1
uniprot id: F6Q7D5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

13616:ING2
gene id: 13616:ING2
uniprot id: F6XRF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:CLPTM1L
gene id: 13616:CLPTM1L
uniprot id: F7EAA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

13616:STN1
gene id: 13616:STN1
uniprot id: F7A106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

13616:GPR65
gene id: 13616:GPR65
uniprot id: F6YMU4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:NHS
gene id: 13616:NHS
uniprot id: A0A5F8HDE7
names: Similarity
messages: Belongs to the NHS family.

13616:PLBD1
gene id: 13616:PLBD1
uniprot id: F7B6W0
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

13616:ELP3
gene id: 13616:ELP3
uniprot id: F6PGK3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

13616:UCMA
gene id: 13616:UCMA
uniprot id: F6QH33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

13616:MAPK14
gene id: 13616:MAPK14
uniprot id: A0A5F8GJU8
uniprot id: F6YAB9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

13616:LOC100015203
gene id: 13616:LOC100015203
uniprot id: F6WM29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:TARDBP
gene id: 13616:TARDBP
uniprot id: A0A5F8GU32
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100015966
gene id: 13616:LOC100015966
uniprot id: F7F9Q2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:LOC100019634
gene id: 13616:LOC100019634
uniprot id: F6YRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PKN2
gene id: 13616:PKN2
uniprot id: A0A5F8G616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

13616:LOC100024563
gene id: 13616:LOC100024563
uniprot id: F7F6A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:OGFRL1
gene id: 13616:OGFRL1
uniprot id: F7G273
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

13616:ALG5
gene id: 13616:ALG5
uniprot id: F6TTN8
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

13616:SIAH1
gene id: 13616:SIAH1
uniprot id: F7DC68
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

13616:ATP5MG
gene id: 13616:ATP5MG
uniprot id: A0A5F8GEH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

13616:ACAT2
gene id: 13616:ACAT2
uniprot id: F6RDB9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:LOC100010924
gene id: 13616:LOC100010924
uniprot id: F6PQ73
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:monDomV1R1246
gene id: 13616:monDomV1R1246
uniprot id: A0A5F8H6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POLR1B
gene id: 13616:POLR1B
uniprot id: F7B818
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

13616:ADRA2A
gene id: 13616:ADRA2A
uniprot id: F6S9H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMEM86A
gene id: 13616:TMEM86A
uniprot id: F6ZQU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

13616:TPD52
gene id: 13616:TPD52
uniprot id: A0A5F8G4J0
uniprot id: A0A5F8GMK6
uniprot id: A0A5F8HDP1
uniprot id: F7GEU5
names: Similarity
messages: Belongs to the TPD52 family.

13616:EDN2
gene id: 13616:EDN2
uniprot id: K7E5U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

13616:LTBR
gene id: 13616:LTBR
uniprot id: F7G4F9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:monDomV1R1293
gene id: 13616:monDomV1R1293
uniprot id: A0A5F8G6I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GBGT1
gene id: 13616:GBGT1
uniprot id: F6VXM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

13616:ATP5F1B
gene id: 13616:ATP5F1B
uniprot id: H9H7I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

13616:PM20D2
gene id: 13616:PM20D2
uniprot id: A0A5F8GBU6
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

13616:TMEM175
gene id: 13616:TMEM175
uniprot id: A0A5F8H9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

13616:MVP
gene id: 13616:MVP
uniprot id: A0A5F8GFC1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

13616:LOC100013978
gene id: 13616:LOC100013978
uniprot id: A0A5F8HCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:BLCAP
gene id: 13616:BLCAP
uniprot id: F7EWW2
names: Similarity
messages: Belongs to the BLCAP family.

13616:MYOG
gene id: 13616:MYOG
uniprot id: F6ZFK9
names: Subcellular Location Annotation
messages: Nucleus

13616:ETV2
gene id: 13616:ETV2
uniprot id: A0A5F8G8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:ANTXR2
gene id: 13616:ANTXR2
uniprot id: A0A5F8HLH9
uniprot id: F6S811
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:MIC-like
gene id: 13616:MIC-like
uniprot id: D7URV4
names: Similarity
messages: Belongs to the MHC class I family.

13616:SPATS2L
gene id: 13616:SPATS2L
uniprot id: F6PMD7
names: Similarity
messages: Belongs to the SPATS2 family.

13616:GPRC5A
gene id: 13616:GPRC5A
uniprot id: F6PGM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:ACTR1A
gene id: 13616:ACTR1A
uniprot id: F6R1W9
names: Similarity
messages: Belongs to the actin family.

13616:TOR3A
gene id: 13616:TOR3A
uniprot id: F7FEZ8
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

13616:LOC100022881
gene id: 13616:LOC100022881
uniprot id: A0A5F8GQ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PGM2
gene id: 13616:PGM2
uniprot id: F7B0S5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

13616:LOC100025096
gene id: 13616:LOC100025096
uniprot id: F6YKE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

13616:NKX2-5
gene id: 13616:NKX2-5
uniprot id: F7BSL0
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103098226
gene id: 13616:LOC103098226
uniprot id: K7E4I9
names: Subcellular Location Annotation
messages: Nucleus

13616:ACTN3
gene id: 13616:ACTN3
uniprot id: F7EL30
names: Similarity
messages: Belongs to the alpha-actinin family.

13616:SCD5
gene id: 13616:SCD5
uniprot id: F7B9J1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

13616:SLC16A3
gene id: 13616:SLC16A3
uniprot id: F7GBJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

13616:DDX41
gene id: 13616:DDX41
uniprot id: F6QGJ3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

13616:CENPI
gene id: 13616:CENPI
uniprot id: F7DFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

13616:ACAD8
gene id: 13616:ACAD8
uniprot id: F7CGB6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:OVOL1
gene id: 13616:OVOL1
uniprot id: A0A5F8HDX3
names: Subcellular Location Annotation
messages: Nucleus

13616:ATG9B
gene id: 13616:ATG9B
uniprot id: A0A5F8GNS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

13616:VN2R506
gene id: 13616:VN2R506
uniprot id: F6QLA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100029087
gene id: 13616:LOC100029087
uniprot id: A0A5F8GNG0
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100017328
gene id: 13616:LOC100017328
uniprot id: A0A5F8HF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

13616:LOC100032638
gene id: 13616:LOC100032638
uniprot id: F6TJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

13616:KDM3B
gene id: 13616:KDM3B
uniprot id: F7DHY8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

13616:CLDN15
gene id: 13616:CLDN15
uniprot id: F7ER03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:IFRD2
gene id: 13616:IFRD2
uniprot id: A0A5F8G5Z6
uniprot id: F7CY73
names: Similarity
messages: Belongs to the IFRD family.

13616:GIPC1
gene id: 13616:GIPC1
uniprot id: F7ALU7
names: Similarity
messages: Belongs to the GIPC family.

13616:THUMPD3
gene id: 13616:THUMPD3
uniprot id: F6QGW7
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:LOC100010487
gene id: 13616:LOC100010487
uniprot id: F6YEH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:RNASEH2A
gene id: 13616:RNASEH2A
uniprot id: F6XVJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

13616:GNL2
gene id: 13616:GNL2
uniprot id: F7DJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

13616:LOC100619842
gene id: 13616:LOC100619842
uniprot id: F6ZZ92
names: Subcellular Location Annotation
messages: Membrane

13616:CHST10
gene id: 13616:CHST10
uniprot id: A0A5F8HDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:TYK2
gene id: 13616:TYK2
uniprot id: F6V3I2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

13616:LMNB2
gene id: 13616:LMNB2
uniprot id: F6UM44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

13616:C1H10orf53
gene id: 13616:C1H10orf53
uniprot id: F6TCD6
names: Similarity
messages: Belongs to the UPF0728 family.

13616:WARS1
gene id: 13616:WARS1
uniprot id: F7ACJ5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:AP5M1
gene id: 13616:AP5M1
uniprot id: F7BJT0
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

13616:TMEM59L
gene id: 13616:TMEM59L
uniprot id: F7GBI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100031124
gene id: 13616:LOC100031124
uniprot id: A0A5F8HAU3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100010425
gene id: 13616:LOC100010425
uniprot id: A0A5F8G372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

13616:PLAT
gene id: 13616:PLAT
uniprot id: A0A5F8G353
uniprot id: F6WLY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:MST1
gene id: 13616:MST1
uniprot id: F7G1K1
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:UCKL1
gene id: 13616:UCKL1
uniprot id: A0A5F8GEJ6
uniprot id: A0A5F8H2N1
uniprot id: F6Y033
names: Similarity
messages: Belongs to the uridine kinase family.

13616:MMS19
gene id: 13616:MMS19
uniprot id: F6VF05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

13616:ALDOC
gene id: 13616:ALDOC
uniprot id: F6Q8Q1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

13616:CNTN2
gene id: 13616:CNTN2
uniprot id: A0A5F8HC49
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

13616:GABRD
gene id: 13616:GABRD
uniprot id: A0A5F8GJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:MSX1
gene id: 13616:MSX1
uniprot id: F7EMU7
names: Subcellular Location Annotation
messages: Nucleus

13616:IFT46
gene id: 13616:IFT46
uniprot id: A0A5F8GSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

13616:LRRC8A
gene id: 13616:LRRC8A
uniprot id: F7F2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:BCL2L13
gene id: 13616:BCL2L13
uniprot id: F7CU62
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:GAB2
gene id: 13616:GAB2
uniprot id: A0A5F8GJS8
names: Similarity
messages: Belongs to the GAB family.

13616:ACAD9
gene id: 13616:ACAD9
uniprot id: F7GES9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:TGFB3
gene id: 13616:TGFB3
uniprot id: F6VL66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

13616:LOC100031194
gene id: 13616:LOC100031194
uniprot id: A0A5F8G4S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:IP6K2
gene id: 13616:IP6K2
uniprot id: F6UYJ2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:NME7
gene id: 13616:NME7
uniprot id: F6Q3R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

13616:ENDOG
gene id: 13616:ENDOG
uniprot id: F7FGU3
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

13616:GASK1B
gene id: 13616:GASK1B
uniprot id: F6VJU0
names: Similarity
messages: Belongs to the GASK family.

13616:GPT2
gene id: 13616:GPT2
uniprot id: F7CTM0
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

13616:CMAS
gene id: 13616:CMAS
uniprot id: F7EKV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

13616:LOC100022683
gene id: 13616:LOC100022683
uniprot id: F6ZCG0
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

13616:KCNK6
gene id: 13616:KCNK6
uniprot id: F7B062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:LOC100015635
gene id: 13616:LOC100015635
uniprot id: A0A5F8GT50
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100026094
gene id: 13616:LOC100026094
uniprot id: A0A5F8G4P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

13616:ZFP36
gene id: 13616:ZFP36
uniprot id: A0A5F8H080
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

13616:SLC16A6
gene id: 13616:SLC16A6
uniprot id: F6W8B1
names: Subcellular Location Annotation
messages: Membrane

13616:BLK
gene id: 13616:BLK
uniprot id: F7B9H2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:RGN
gene id: 13616:RGN
uniprot id: F6R929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

13616:SNX20
gene id: 13616:SNX20
uniprot id: F7FBP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

13616:RPRD1A
gene id: 13616:RPRD1A
uniprot id: A0A5F8HKZ2
uniprot id: F6QN59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

13616:RNPEP
gene id: 13616:RNPEP
uniprot id: F6Y513
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:LOC100015895
gene id: 13616:LOC100015895
uniprot id: F7F9P8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:GNPTAB
gene id: 13616:GNPTAB
uniprot id: F6XPQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

13616:LOC100620004
gene id: 13616:LOC100620004
uniprot id: A0A5F8GP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

13616:ATP6V0D1
gene id: 13616:ATP6V0D1
uniprot id: F6XCI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:PARP1
gene id: 13616:PARP1
uniprot id: F7FES2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

13616:ANTXRL
gene id: 13616:ANTXRL
uniprot id: F6W852
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:NUMB
gene id: 13616:NUMB
uniprot id: A0A5F8G359
uniprot id: A0A5F8GIT3
uniprot id: F7CD96
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

13616:SLC34A3
gene id: 13616:SLC34A3
uniprot id: F6XEY4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

13616:ODF2
gene id: 13616:ODF2
uniprot id: F7FEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

13616:HOXB13
gene id: 13616:HOXB13
uniprot id: F7EIT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

13616:POLR3H
gene id: 13616:POLR3H
uniprot id: A0A5F8H6V3
uniprot id: H9H6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

13616:LIN28A
gene id: 13616:LIN28A
uniprot id: F6T943
names: Similarity
messages: Belongs to the lin-28 family.

13616:POMT2
gene id: 13616:POMT2
uniprot id: F7CGH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

13616:LOXL3
gene id: 13616:LOXL3
uniprot id: F7FDE6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

13616:LOC100026007
gene id: 13616:LOC100026007
uniprot id: F7D2Z8
names: Similarity
messages: Belongs to the MHC class II family.

13616:LOC100020659
gene id: 13616:LOC100020659
uniprot id: K7E0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:LOC100031667
gene id: 13616:LOC100031667
uniprot id: F7GGE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

13616:BOK
gene id: 13616:BOK
uniprot id: F7G9S0
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:PUS3
gene id: 13616:PUS3
uniprot id: A0A5F8G1Y4
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

13616:SUSD6
gene id: 13616:SUSD6
uniprot id: F6T5F1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LNPK
gene id: 13616:LNPK
uniprot id: A0A5F8H9H1
uniprot id: K7E0B9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

13616:PHF20L1
gene id: 13616:PHF20L1
uniprot id: F7GHB9
names: Subcellular Location Annotation
messages: Nucleus

13616:IL4I1
gene id: 13616:IL4I1
uniprot id: A0A5F8HC18
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

13616:TJAP1
gene id: 13616:TJAP1
uniprot id: A0A5F8GEE0
uniprot id: A0A5F8GMX1
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103099228
gene id: 13616:LOC103099228
uniprot id: A0A5F8GQJ1
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ECHS1
gene id: 13616:ECHS1
uniprot id: F7ESK8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:LOC100028416
gene id: 13616:LOC100028416
uniprot id: A0A5F8H1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARHGDIB
gene id: 13616:ARHGDIB
uniprot id: F7E3S1
names: Similarity
messages: Belongs to the Rho GDI family.

13616:DNAJB14
gene id: 13616:DNAJB14
uniprot id: F7DKI6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PIN4
gene id: 13616:PIN4
uniprot id: A0A5F8GMX7
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

13616:INSIG2
gene id: 13616:INSIG2
uniprot id: A0A5F8G5H3
uniprot id: A0A5F8GA97
uniprot id: F6US40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

13616:GEMIN2
gene id: 13616:GEMIN2
uniprot id: A0A5F8G5H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

13616:CLRN1
gene id: 13616:CLRN1
uniprot id: A0A5F8HGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:TNFAIP3
gene id: 13616:TNFAIP3
uniprot id: F7AJC4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:OTX2
gene id: 13616:OTX2
uniprot id: A0A5F8GEK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:BAZ1A
gene id: 13616:BAZ1A
uniprot id: A0A5F8GW38
uniprot id: F7G1J7
names: Subcellular Location Annotation
messages: Nucleus

13616:RPL7A
gene id: 13616:RPL7A
uniprot id: F6SJL4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

13616:DDX10
gene id: 13616:DDX10
uniprot id: F6ZEQ2
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

13616:SRMS
gene id: 13616:SRMS
uniprot id: F6XJB6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:GGH
gene id: 13616:GGH
uniprot id: F7FU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

13616:ADRA2B
gene id: 13616:ADRA2B
uniprot id: F7G5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

13616:ABCC9
gene id: 13616:ABCC9
uniprot id: A0A5F8G687
uniprot id: A0A5F8GAT2
uniprot id: F6RD25
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

13616:ALDH1A2
gene id: 13616:ALDH1A2
uniprot id: F6PGG8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

13616:MMP2
gene id: 13616:MMP2
uniprot id: A0A5F8H9W3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

13616:CLDN20
gene id: 13616:CLDN20
uniprot id: F6SEP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:LOC100024593
gene id: 13616:LOC100024593
uniprot id: F6PYX9
names: Similarity
messages: Belongs to the serpin family.

13616:LOC100009995
gene id: 13616:LOC100009995
uniprot id: F6QZ90
names: Similarity
messages: Belongs to the sulfatase family.

13616:ELOVL5
gene id: 13616:ELOVL5
uniprot id: F6ZMF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

13616:DNAJC18
gene id: 13616:DNAJC18
uniprot id: F7CB96
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:L3MBTL3
gene id: 13616:L3MBTL3
uniprot id: F6ZT57
names: Subcellular Location Annotation
messages: Nucleus

13616:PRPF3
gene id: 13616:PRPF3
uniprot id: K7E1G2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

13616:LOC100026079
gene id: 13616:LOC100026079
uniprot id: A0A5F8GBM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:STC2
gene id: 13616:STC2
uniprot id: F7BSU8
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

13616:FGFR2
gene id: 13616:FGFR2
uniprot id: F7DHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:JPH3
gene id: 13616:JPH3
uniprot id: F6RTX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

13616:ENTREP1
gene id: 13616:ENTREP1
uniprot id: F7E297
names: Similarity
messages: Belongs to the ENTREP family.

13616:GTF2E2
gene id: 13616:GTF2E2
uniprot id: F7CP70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

13616:PPP1R3C
gene id: 13616:PPP1R3C
uniprot id: F7CCR6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

13616:HBE1
gene id: 13616:HBE1
uniprot id: F6WII6
names: Similarity
messages: Belongs to the globin family.

13616:CMTM7
gene id: 13616:CMTM7
uniprot id: A0A5F8H0V6
names: Subcellular Location Annotation
messages: Membrane

13616:NT5C2
gene id: 13616:NT5C2
uniprot id: A0A5F8GVB7
uniprot id: F7ANM0
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:EBF2
gene id: 13616:EBF2
uniprot id: A0A5F8H5N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

13616:SH3GL3
gene id: 13616:SH3GL3
uniprot id: A0A5F8GI38
uniprot id: A0A5F8H9K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

13616:LOC100024961
gene id: 13616:LOC100024961
uniprot id: F6X182
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

13616:FIGNL1
gene id: 13616:FIGNL1
uniprot id: F6U499
names: Similarity
messages: Belongs to the AAA ATPase family.

13616:KAT2B
gene id: 13616:KAT2B
uniprot id: F7A3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

13616:DHRS7B
gene id: 13616:DHRS7B
uniprot id: A0A5F8GVW3
uniprot id: A0A5F8H473
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:SARM1
gene id: 13616:SARM1
uniprot id: F6QTG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

13616:POLR2F
gene id: 13616:POLR2F
uniprot id: H9H794
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

13616:REC8
gene id: 13616:REC8
uniprot id: F6ZPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

13616:YY1
gene id: 13616:YY1
uniprot id: F7BM88
names: Similarity
messages: Belongs to the YY transcription factor family.

13616:SLC18A2
gene id: 13616:SLC18A2
uniprot id: F7BLF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

13616:DNAJC2
gene id: 13616:DNAJC2
uniprot id: F6WHU3
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

13616:MCIDAS
gene id: 13616:MCIDAS
uniprot id: A0A5F8HJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

13616:PBX4
gene id: 13616:PBX4
uniprot id: A0A5F8HE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

13616:RAB39B
gene id: 13616:RAB39B
uniprot id: H9H6X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

13616:SLC46A1
gene id: 13616:SLC46A1
uniprot id: F6QTF6
names: Subcellular Location Annotation
messages: Membrane

13616:BDKRB1
gene id: 13616:BDKRB1
uniprot id: F6T0H1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

13616:C2H1orf52
gene id: 13616:C2H1orf52
uniprot id: F6WAF9
names: Similarity
messages: Belongs to the UPF0690 family.

13616:ST8SIA2
gene id: 13616:ST8SIA2
uniprot id: F6ZL24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:RSBN1
gene id: 13616:RSBN1
uniprot id: F6VPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

13616:SLC41A1
gene id: 13616:SLC41A1
uniprot id: F6SNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

13616:IRX5
gene id: 13616:IRX5
uniprot id: F7EWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:TRH
gene id: 13616:TRH
uniprot id: K7E2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

13616:WDFY1
gene id: 13616:WDFY1
uniprot id: F6XE34
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

13616:SLC35C2
gene id: 13616:SLC35C2
uniprot id: A0A5F8H2Q5
names: Subcellular Location Annotation
messages: Membrane

13616:SIAH3
gene id: 13616:SIAH3
uniprot id: K7E4P4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

13616:ATP1B1
gene id: 13616:ATP1B1
uniprot id: F6Q505
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

13616:SLC1A6
gene id: 13616:SLC1A6
uniprot id: A0A5F8G9Q7
uniprot id: F7FKW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:TOR1A
gene id: 13616:TOR1A
uniprot id: F6PGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

13616:LOC103102651
gene id: 13616:LOC103102651
uniprot id: A0A5F8GQ48
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

13616:VN2R530
gene id: 13616:VN2R530
uniprot id: F6PSJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PRKACA
gene id: 13616:PRKACA
uniprot id: F7G4Q0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

13616:USP10
gene id: 13616:USP10
uniprot id: F6Y299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:NDRG3
gene id: 13616:NDRG3
uniprot id: A0A5F8G7C2
uniprot id: F7FW54
names: Similarity
messages: Belongs to the NDRG family.

13616:FSCN2
gene id: 13616:FSCN2
uniprot id: F7DHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

13616:MCM10
gene id: 13616:MCM10
uniprot id: F6QH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

13616:PA2G4
gene id: 13616:PA2G4
uniprot id: H9H5Z3
names: Similarity
messages: Belongs to the peptidase M24 family.

13616:LOC103097229
gene id: 13616:LOC103097229
uniprot id: A0A5F8H8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:F2R
gene id: 13616:F2R
uniprot id: F7BHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DPYD
gene id: 13616:DPYD
uniprot id: F6VWD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

13616:LOC100017995
gene id: 13616:LOC100017995
uniprot id: A0A5F8GE62
names: Subcellular Location Annotation
messages: nucleoplasm

13616:PACS2
gene id: 13616:PACS2
uniprot id: F7E808
names: Similarity
messages: Belongs to the PACS family.

13616:KDM1A
gene id: 13616:KDM1A
uniprot id: F7D7I0
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

13616:NLK
gene id: 13616:NLK
uniprot id: F6RE45
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

13616:ACTMAP
gene id: 13616:ACTMAP
uniprot id: F6TXU5
names: Similarity
messages: Belongs to the ACTMAP family.

13616:LOC100018927
gene id: 13616:LOC100018927
uniprot id: F7CDT3
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:PLLP
gene id: 13616:PLLP
uniprot id: F7DRN4
names: Subcellular Location Annotation
messages: Membrane

13616:KCNF1
gene id: 13616:KCNF1
uniprot id: F7D2C1
names: Subcellular Location Annotation
messages: Membrane

13616:TMEM116
gene id: 13616:TMEM116
uniprot id: F7E2L0
names: Subcellular Location Annotation
messages: Membrane

13616:SEZ6L2
gene id: 13616:SEZ6L2
uniprot id: A0A5F8GRA9
uniprot id: A0A5F8GSC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:EPHB6
gene id: 13616:EPHB6
uniprot id: F7ES42
names: Subcellular Location Annotation
messages: Membrane

13616:WDR48
gene id: 13616:WDR48
uniprot id: A0A5F8HFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

13616:UBL4B
gene id: 13616:UBL4B
uniprot id: Q19KS6
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.

13616:PAM16
gene id: 13616:PAM16
uniprot id: A0A5F8GWL2
uniprot id: F7ER96
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

13616:BCDIN3D
gene id: 13616:BCDIN3D
uniprot id: A0A5F8HB75
names: Similarity
messages: Belongs to the methyltransferase superfamily.

13616:IGF1
gene id: 13616:IGF1
uniprot id: F6Y770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

13616:BCO2
gene id: 13616:BCO2
uniprot id: F6TNK3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

13616:LOC100024383
gene id: 13616:LOC100024383
uniprot id: A0A5F8G959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:ATP10D
gene id: 13616:ATP10D
uniprot id: F6ZB11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:RMI1
gene id: 13616:RMI1
uniprot id: F7FCW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

13616:LOC100023722
gene id: 13616:LOC100023722
uniprot id: F7AWM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

13616:NTNG2
gene id: 13616:NTNG2
uniprot id: A0A5F8HKK9
uniprot id: F6Q0S1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:FAM219A
gene id: 13616:FAM219A
uniprot id: A0A5F8GZ01
names: Similarity
messages: Belongs to the FAM219 family.

13616:GMFG
gene id: 13616:GMFG
uniprot id: F7FMW6
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

13616:LOC100028327
gene id: 13616:LOC100028327
uniprot id: F6RQ25
names: Subcellular Location Annotation
messages: Membrane

13616:L3MBTL4
gene id: 13616:L3MBTL4
uniprot id: F7GLP9
names: Subcellular Location Annotation
messages: Nucleus

13616:KCNA2
gene id: 13616:KCNA2
uniprot id: F6UCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

13616:IFT20
gene id: 13616:IFT20
uniprot id: F6RDW6
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

13616:MTCH1
gene id: 13616:MTCH1
uniprot id: F7FM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:monDomV1R1289
gene id: 13616:monDomV1R1289
uniprot id: A0A5F8H6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PIK3CG
gene id: 13616:PIK3CG
uniprot id: F7E9G2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:LOC100024128
gene id: 13616:LOC100024128
uniprot id: F7EI19
names: Subcellular Location Annotation
messages: Membrane

13616:GUCA2A
gene id: 13616:GUCA2A
uniprot id: F6WWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

13616:DIS3
gene id: 13616:DIS3
uniprot id: F6TF04
names: Similarity
messages: Belongs to the RNR ribonuclease family.

13616:ALG10
gene id: 13616:ALG10
uniprot id: F6RK69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

13616:monDomV1R1271
gene id: 13616:monDomV1R1271
uniprot id: A0A5F8GCC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:POC5
gene id: 13616:POC5
uniprot id: F6Q4B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

13616:IGFBP1
gene id: 13616:IGFBP1
uniprot id: F6XGI9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:POP7
gene id: 13616:POP7
uniprot id: F6R4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

13616:GORASP2
gene id: 13616:GORASP2
uniprot id: F7DHB7
names: Similarity
messages: Belongs to the GORASP family.

13616:LOC100617410
gene id: 13616:LOC100617410
uniprot id: F7C814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NPPC
gene id: 13616:NPPC
uniprot id: F7B965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

13616:ADIPOR1
gene id: 13616:ADIPOR1
uniprot id: F7AV52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:HSPA12A
gene id: 13616:HSPA12A
uniprot id: A0A5F8GJ38
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:LOC100023114
gene id: 13616:LOC100023114
uniprot id: F7DGD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100023235
gene id: 13616:LOC100023235
uniprot id: F7G5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:OTUB2
gene id: 13616:OTUB2
uniprot id: A0A5F8GCF4
uniprot id: A0A5F8HBX7
names: Similarity
messages: Belongs to the peptidase C65 family.

13616:B4GALT7
gene id: 13616:B4GALT7
uniprot id: F6TER0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:CNTF
gene id: 13616:CNTF
uniprot id: A0A5F8HE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

13616:LOC103093927
gene id: 13616:LOC103093927
uniprot id: A0A5F8HKH0
names: Similarity
messages: Belongs to the cystatin family.

13616:CCT3
gene id: 13616:CCT3
uniprot id: F6XJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:DYNLRB2
gene id: 13616:DYNLRB2
uniprot id: F7ELI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

13616:MOGS
gene id: 13616:MOGS
uniprot id: F7FL90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

13616:NPHS2
gene id: 13616:NPHS2
uniprot id: F7BSK5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

13616:BAG6
gene id: 13616:BAG6
uniprot id: A0A5F8HL30
uniprot id: F6VB03
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: cytosol
messages: extracellular exosome

13616:STK38
gene id: 13616:STK38
uniprot id: F7C3H3
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LOC100029871
gene id: 13616:LOC100029871
uniprot id: F7BKP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:ACOT13
gene id: 13616:ACOT13
uniprot id: A0A5F8HCZ3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

13616:LOC100024194
gene id: 13616:LOC100024194
uniprot id: F7A1K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NIPSNAP1
gene id: 13616:NIPSNAP1
uniprot id: A0A5F8GTP3
names: Similarity
messages: Belongs to the NipSnap family.

13616:NMBR
gene id: 13616:NMBR
uniprot id: F6SMW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1294
gene id: 13616:monDomV1R1294
uniprot id: A0A5F8H8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ETNPPL
gene id: 13616:ETNPPL
uniprot id: A0A5F8GS08
uniprot id: F7A071
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

13616:CC2D1B
gene id: 13616:CC2D1B
uniprot id: F6W5J6
names: Similarity
messages: Belongs to the CC2D1 family.

13616:LOC100024470
gene id: 13616:LOC100024470
uniprot id: F7FFX8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

13616:AMER3
gene id: 13616:AMER3
uniprot id: F7B2Z7
names: Similarity
messages: Belongs to the Amer family.

13616:CUL1
gene id: 13616:CUL1
uniprot id: F6T584
names: Similarity
messages: Belongs to the cullin family.

13616:LIAS
gene id: 13616:LIAS
uniprot id: F7AQ30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

13616:POLR2I
gene id: 13616:POLR2I
uniprot id: F6U7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

13616:INTS8
gene id: 13616:INTS8
uniprot id: F6Q8M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

13616:MAP4K3
gene id: 13616:MAP4K3
uniprot id: A0A5F8GEP6
uniprot id: A0A5F8GT03
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

13616:PDXP
gene id: 13616:PDXP
uniprot id: A0A5F8GLP3
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

13616:CPZ
gene id: 13616:CPZ
uniprot id: A0A5F8HL88
uniprot id: F6TZK5
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CAPRIN1
gene id: 13616:CAPRIN1
uniprot id: A0A5F8G6E4
names: Similarity
messages: Belongs to the caprin family.

13616:LOC100025667
gene id: 13616:LOC100025667
uniprot id: K7E258
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:ATG9A
gene id: 13616:ATG9A
uniprot id: F6QD19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

13616:CTSS
gene id: 13616:CTSS
uniprot id: F6Z032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:MINDY2
gene id: 13616:MINDY2
uniprot id: F6RGW0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

13616:AMH
gene id: 13616:AMH
uniprot id: F6TR95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

13616:AMIGO1
gene id: 13616:AMIGO1
uniprot id: F6TWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

13616:SLC39A3
gene id: 13616:SLC39A3
uniprot id: F7CKN7
names: Subcellular Location Annotation
messages: Membrane

13616:CCT8L2
gene id: 13616:CCT8L2
uniprot id: H9H860
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

13616:APIP
gene id: 13616:APIP
uniprot id: A0A5F8GU04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

13616:FGF3
gene id: 13616:FGF3
uniprot id: K7E687
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:LOC100018393
gene id: 13616:LOC100018393
uniprot id: F6VEU5
names: Subcellular Location Annotation
messages: Membrane

13616:MRPS15
gene id: 13616:MRPS15
uniprot id: F6ZXY2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

13616:LOC100013421
gene id: 13616:LOC100013421
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ISCU
gene id: 13616:ISCU
uniprot id: A0A5F8G6L9
uniprot id: F6UVD9
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

13616:NDOR1
gene id: 13616:NDOR1
uniprot id: F6XFL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

13616:SUMF1
gene id: 13616:SUMF1
uniprot id: A0A5F8GW27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

13616:LOC100013297
gene id: 13616:LOC100013297
uniprot id: F6RS65
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

13616:CDADC1
gene id: 13616:CDADC1
uniprot id: A0A5F8H477
uniprot id: F7A1J3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

13616:GCK
gene id: 13616:GCK
uniprot id: A0A5F8GL04
uniprot id: F7G8R6
names: Similarity
messages: Belongs to the hexokinase family.

13616:LOC100022343
gene id: 13616:LOC100022343
uniprot id: F7BJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

13616:CSF1R
gene id: 13616:CSF1R
uniprot id: F6WT52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:MID2
gene id: 13616:MID2
uniprot id: F6TIP4
names: Subcellular Location Annotation
messages: cytoskeleton

13616:LOC100026015
gene id: 13616:LOC100026015
uniprot id: F7D5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100020065
gene id: 13616:LOC100020065
uniprot id: F7C6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:PNCK
gene id: 13616:PNCK
uniprot id: F7DJS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:SLC17A6
gene id: 13616:SLC17A6
uniprot id: F6YX10
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100022644
gene id: 13616:LOC100022644
uniprot id: A0A5F8GVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HMGA1
gene id: 13616:HMGA1
uniprot id: F6SBW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

13616:DHTKD1
gene id: 13616:DHTKD1
uniprot id: F7FVJ6
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

13616:LOC100027960
gene id: 13616:LOC100027960
uniprot id: A0A5F8G298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VIP
gene id: 13616:VIP
uniprot id: F7FG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

13616:SGK2
gene id: 13616:SGK2
uniprot id: F7CJ36
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:GNB2
gene id: 13616:GNB2
uniprot id: F6Y3N2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:TMEM63A
gene id: 13616:TMEM63A
uniprot id: F6WW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

13616:ACSS3
gene id: 13616:ACSS3
uniprot id: F7FIW5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:TMEM150A
gene id: 13616:TMEM150A
uniprot id: F6YFN8
names: Subcellular Location Annotation
messages: Membrane

13616:AEBP1
gene id: 13616:AEBP1
uniprot id: F7G8P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

13616:RIPOR3
gene id: 13616:RIPOR3
uniprot id: A0A5F8HHW7
uniprot id: F7FKL6
names: Similarity
messages: Belongs to the RIPOR family.

13616:HAPLN1
gene id: 13616:HAPLN1
uniprot id: A0A5F8GM11
uniprot id: A0A5F8H7V8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MAL
gene id: 13616:MAL
uniprot id: A0A5F8G6T8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100031275
gene id: 13616:LOC100031275
uniprot id: A0A5F8H6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NDUFA6
gene id: 13616:NDUFA6
uniprot id: F6UFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:TMEM150B
gene id: 13616:TMEM150B
uniprot id: H9H624
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100017853
gene id: 13616:LOC100017853
uniprot id: A0A5F8HD68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:MAN1A1
gene id: 13616:MAN1A1
uniprot id: F7DJC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:B3GAT2
gene id: 13616:B3GAT2
uniprot id: F7G261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:RGS2
gene id: 13616:RGS2
uniprot id: F7FUH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

13616:CNOT7
gene id: 13616:CNOT7
uniprot id: F7AXX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:SMARCA5
gene id: 13616:SMARCA5
uniprot id: F6R7X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

13616:NXPH3
gene id: 13616:NXPH3
uniprot id: A0A5F8HFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

13616:LOC100013915
gene id: 13616:LOC100013915
uniprot id: A0A5F8HDP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ODR4
gene id: 13616:ODR4
uniprot id: F6YEE1
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

13616:ANKRD13A
gene id: 13616:ANKRD13A
uniprot id: F6SX00
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

13616:TFE3
gene id: 13616:TFE3
uniprot id: F6R8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

13616:CCKBR
gene id: 13616:CCKBR
uniprot id: A0A5F8G2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CCDC47
gene id: 13616:CCDC47
uniprot id: F6R7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

13616:DNASE2B
gene id: 13616:DNASE2B
uniprot id: F6Y5N6
names: Similarity
messages: Belongs to the DNase II family.

13616:CKMT1A
gene id: 13616:CKMT1A
uniprot id: F7DJD6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

13616:LOC100012618
gene id: 13616:LOC100012618
uniprot id: A0A5F8HI30
uniprot id: F7FZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:GLYCTK
gene id: 13616:GLYCTK
uniprot id: A0A5F8G2H8
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

13616:TMEM255A
gene id: 13616:TMEM255A
uniprot id: F6VLX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

13616:PPP1R16B
gene id: 13616:PPP1R16B
uniprot id: F7BMC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PSAT1
gene id: 13616:PSAT1
uniprot id: F7DC74
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

13616:SLC39A9
gene id: 13616:SLC39A9
uniprot id: A0A5F8GEC8
uniprot id: A0A5F8HHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

13616:PDE7A
gene id: 13616:PDE7A
uniprot id: A0A5F8GWM4
uniprot id: F7ELV9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:TBXA2R
gene id: 13616:TBXA2R
uniprot id: F6W8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:AKR1E2
gene id: 13616:AKR1E2
uniprot id: F7DXB7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

13616:C1H16orf87
gene id: 13616:C1H16orf87
uniprot id: F7DY20
names: Similarity
messages: Belongs to the UPF0547 family.

13616:LOC100029519
gene id: 13616:LOC100029519
uniprot id: F6YBH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

13616:MAP3K5
gene id: 13616:MAP3K5
uniprot id: F6UTB5
uniprot id: F6ZUM0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

13616:LOC100010381
gene id: 13616:LOC100010381
uniprot id: F6U2E9
names: Similarity
messages: Belongs to the peptidase C1 family.

13616:LOC100021392
gene id: 13616:LOC100021392
uniprot id: F6ZZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HYAL2
gene id: 13616:HYAL2
uniprot id: F7FU16
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

13616:CIAO3
gene id: 13616:CIAO3
uniprot id: F7FVH9
names: Similarity
messages: Belongs to the NARF family.

13616:SH3BGRL
gene id: 13616:SH3BGRL
uniprot id: F6X6Y2
names: Similarity
messages: Belongs to the SH3BGR family.

13616:GPR83
gene id: 13616:GPR83
uniprot id: F6SGG3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:monDomV1R1226
gene id: 13616:monDomV1R1226
uniprot id: F7F0Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100031971
gene id: 13616:LOC100031971
uniprot id: F7G922
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:MRPL10
gene id: 13616:MRPL10
uniprot id: A0A5F8GLG1
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

13616:LDAF1
gene id: 13616:LDAF1
uniprot id: F6WTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

13616:LOC100030497
gene id: 13616:LOC100030497
uniprot id: A0A5F8GAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

13616:TP53INP2
gene id: 13616:TP53INP2
uniprot id: F7DHX4
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

13616:EIF1AX
gene id: 13616:EIF1AX
uniprot id: K7E1Z1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

13616:SLC9A3
gene id: 13616:SLC9A3
uniprot id: A0A5F8H3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

13616:LOC100031601
gene id: 13616:LOC100031601
uniprot id: F6VB69
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

13616:RAX
gene id: 13616:RAX
uniprot id: F7ARM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:LOC100618325
gene id: 13616:LOC100618325
uniprot id: A0A5F8GGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GLS2
gene id: 13616:GLS2
uniprot id: F6QBQ6
names: Similarity
messages: Belongs to the glutaminase family.

13616:STRADB
gene id: 13616:STRADB
uniprot id: A0A5F8GG15
uniprot id: F6V4E1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

13616:CCNK
gene id: 13616:CCNK
uniprot id: F7FQ20
names: Similarity
messages: Belongs to the cyclin family.

13616:CRYBA1
gene id: 13616:CRYBA1
uniprot id: F6XTA6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:CHST12
gene id: 13616:CHST12
uniprot id: F6XP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100012199
gene id: 13616:LOC100012199
uniprot id: A0A5F8GBC3
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

13616:MYOZ1
gene id: 13616:MYOZ1
uniprot id: F6WB86
names: Similarity
messages: Belongs to the myozenin family.

13616:PDRG1
gene id: 13616:PDRG1
uniprot id: F6WAE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

13616:CAVIN3
gene id: 13616:CAVIN3
uniprot id: F7FD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

13616:ACOX3
gene id: 13616:ACOX3
uniprot id: F6WE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

13616:NPM2
gene id: 13616:NPM2
uniprot id: F7D8H7
names: Similarity
messages: Belongs to the nucleoplasmin family.

13616:TRMU
gene id: 13616:TRMU
uniprot id: F7DWM5
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

13616:TMEM183A
gene id: 13616:TMEM183A
uniprot id: F6ZGV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

13616:TWSG1
gene id: 13616:TWSG1
uniprot id: F7BT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

13616:LOC100030353
gene id: 13616:LOC100030353
uniprot id: F7F1K4
names: Subcellular Location Annotation
messages: Membrane

13616:GATM
gene id: 13616:GATM
uniprot id: F6Z4H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

13616:ACP1
gene id: 13616:ACP1
uniprot id: F7G3D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

13616:LOC100028079
gene id: 13616:LOC100028079
uniprot id: A0A5F8HDN2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:GPN2
gene id: 13616:GPN2
uniprot id: A0A5F8GM25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

13616:BMT2
gene id: 13616:BMT2
uniprot id: A0A5F8GI30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

13616:RPL22L1
gene id: 13616:RPL22L1
uniprot id: A0A5F8GTT4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

13616:CDKN1A
gene id: 13616:CDKN1A
uniprot id: F7D6Q4
names: Similarity
messages: Belongs to the CDI family.

13616:NRAS
gene id: 13616:NRAS
uniprot id: Q95ME4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7 (By similarity).
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
messages: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.

13616:ADSS1
gene id: 13616:ADSS1
uniprot id: F6TXD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

13616:SNX5
gene id: 13616:SNX5
uniprot id: F7BXX6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:monDomV1R1275
gene id: 13616:monDomV1R1275
uniprot id: A0A5F8G2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATPAF2
gene id: 13616:ATPAF2
uniprot id: A0A5F8G7H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

13616:B3GALT4
gene id: 13616:B3GALT4
uniprot id: F6X7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:RNF114
gene id: 13616:RNF114
uniprot id: F7A674
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

13616:TMEM165
gene id: 13616:TMEM165
uniprot id: F7DL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

13616:FAM171A1
gene id: 13616:FAM171A1
uniprot id: F6Y546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

13616:GDF5
gene id: 13616:GDF5
uniprot id: F6WIE9
names: Similarity
messages: Belongs to the TGF-beta family.

13616:RFX3
gene id: 13616:RFX3
uniprot id: A0A5F8GQW4
uniprot id: F6T459
names: Subcellular Location Annotation
messages: Nucleus

13616:RAD23A
gene id: 13616:RAD23A
uniprot id: A0A5F8G8H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

13616:LOC100014675
gene id: 13616:LOC100014675
uniprot id: A0A5F8HB24
names: Similarity
messages: Belongs to the TCL1 family.

13616:LOC103105715
gene id: 13616:LOC103105715
uniprot id: K7E3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:PLAC8
gene id: 13616:PLAC8
uniprot id: F6RYA5
names: Similarity
messages: Belongs to the cornifelin family.

13616:LRRC8D
gene id: 13616:LRRC8D
uniprot id: A0A5F8HD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016903
gene id: 13616:LOC100016903
uniprot id: F7GEW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:BOP1
gene id: 13616:BOP1
uniprot id: F7GHR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

13616:CDKN2AIP
gene id: 13616:CDKN2AIP
uniprot id: F6Y989
names: Similarity
messages: Belongs to the CARF family.

13616:SCAMP2
gene id: 13616:SCAMP2
uniprot id: F7DA26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

13616:INTS7
gene id: 13616:INTS7
uniprot id: K7E250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

13616:ALOX5AP
gene id: 13616:ALOX5AP
uniprot id: F7DAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NPC1
gene id: 13616:NPC1
uniprot id: F7G2R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

13616:PIERCE2
gene id: 13616:PIERCE2
uniprot id: A0A5F8GKW6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

13616:LSM12
gene id: 13616:LSM12
uniprot id: F7CBC3
names: Similarity
messages: Belongs to the LSM12 family.

13616:LOC100010481
gene id: 13616:LOC100010481
uniprot id: F7B9Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:THBS1
gene id: 13616:THBS1
uniprot id: F6WMA0
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100021136
gene id: 13616:LOC100021136
uniprot id: F6STC9
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100018133
gene id: 13616:LOC100018133
uniprot id: F6V7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NEK9
gene id: 13616:NEK9
uniprot id: F6SL97
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

13616:TPRG1L
gene id: 13616:TPRG1L
uniprot id: K7DZC4
names: Similarity
messages: Belongs to the TPRG1 family.

13616:YIPF4
gene id: 13616:YIPF4
uniprot id: F6WWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100022960
gene id: 13616:LOC100022960
uniprot id: F7DRU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NPVF
gene id: 13616:NPVF
uniprot id: F6TB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

13616:BCAT1
gene id: 13616:BCAT1
uniprot id: F7G5B7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

13616:SIVA1
gene id: 13616:SIVA1
uniprot id: F6TX86
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

13616:PLPP5
gene id: 13616:PLPP5
uniprot id: F7GH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

13616:LOC100018685
gene id: 13616:LOC100018685
uniprot id: F6QC34
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:GPR146
gene id: 13616:GPR146
uniprot id: F6PSI3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100022003
gene id: 13616:LOC100022003
uniprot id: A0A5F8GG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:STAT5A
gene id: 13616:STAT5A
uniprot id: F7CHH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

13616:SLC15A4
gene id: 13616:SLC15A4
uniprot id: A0A5F8GK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

13616:LOC100011978
gene id: 13616:LOC100011978
uniprot id: A0A5F8GZV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ADGRG6
gene id: 13616:ADGRG6
uniprot id: A0A5F8GVE8
uniprot id: A0A5F8HJH7
uniprot id: F6VSG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PARP16
gene id: 13616:PARP16
uniprot id: A0A5F8H951
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:NHERF2
gene id: 13616:NHERF2
uniprot id: A0A5F8GYA2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

13616:LOC100015779
gene id: 13616:LOC100015779
uniprot id: A0A5F8G1X2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:IDO1
gene id: 13616:IDO1
uniprot id: B3Y9H8
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

13616:PTCH1
gene id: 13616:PTCH1
uniprot id: A0A5F8GXF9
uniprot id: F6YGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

13616:TM9SF3
gene id: 13616:TM9SF3
uniprot id: F6UNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:KCNAB1
gene id: 13616:KCNAB1
uniprot id: F7AGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

13616:ECHDC1
gene id: 13616:ECHDC1
uniprot id: F7GFX1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:MFN1
gene id: 13616:MFN1
uniprot id: A0A5F8G366
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:PFDN2
gene id: 13616:PFDN2
uniprot id: A0A5F8H854
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

13616:MC4R
gene id: 13616:MC4R
uniprot id: A8QXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

13616:LOC100618039
gene id: 13616:LOC100618039
uniprot id: A0A5F8HG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100010347
gene id: 13616:LOC100010347
uniprot id: A0A5F8GP65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:LOC100020632
gene id: 13616:LOC100020632
uniprot id: A0A5F8HBE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:BAX
gene id: 13616:BAX
uniprot id: F6XQQ4
names: Similarity
messages: Belongs to the Bcl-2 family.

13616:CWF19L2
gene id: 13616:CWF19L2
uniprot id: F7DN63
names: Similarity
messages: Belongs to the CWF19 family.

13616:SEC23A
gene id: 13616:SEC23A
uniprot id: F7B980
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

13616:ATP5F1C
gene id: 13616:ATP5F1C
uniprot id: A0A5F8G633
uniprot id: F7CHH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

13616:LOC100032364
gene id: 13616:LOC100032364
uniprot id: F6XPY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

13616:POLA1
gene id: 13616:POLA1
uniprot id: F7ADS9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

13616:ANPEP
gene id: 13616:ANPEP
uniprot id: F6UV20
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:EXOC2
gene id: 13616:EXOC2
uniprot id: F7CDZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

13616:ELAPOR2
gene id: 13616:ELAPOR2
uniprot id: F6V5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

13616:B2M
gene id: 13616:B2M
uniprot id: F7G5N8
uniprot id: Q864T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

13616:MEX3C
gene id: 13616:MEX3C
uniprot id: F7A143
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:KCNH2
gene id: 13616:KCNH2
uniprot id: A0A5F8GYC7
uniprot id: F6ZK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

13616:MTMR11
gene id: 13616:MTMR11
uniprot id: F7DXN5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:TEC
gene id: 13616:TEC
uniprot id: F7EN79
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:VN2R544
gene id: 13616:VN2R544
uniprot id: F7C9N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:UFL1
gene id: 13616:UFL1
uniprot id: A0A5F8HF34
names: Similarity
messages: Belongs to the UFL1 family.

13616:NADK
gene id: 13616:NADK
uniprot id: A0A5F8GV69
names: Similarity
messages: Belongs to the NAD kinase family.

13616:AGTR1
gene id: 13616:AGTR1
uniprot id: F7GKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

13616:SFMBT2
gene id: 13616:SFMBT2
uniprot id: F7E6I1
names: Subcellular Location Annotation
messages: Nucleus

13616:TMEM59
gene id: 13616:TMEM59
uniprot id: H9H801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:SDE2
gene id: 13616:SDE2
uniprot id: F6VZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

13616:SLC44A2
gene id: 13616:SLC44A2
uniprot id: A0A5F8HFR3
uniprot id: A0A5F8HGM4
uniprot id: F6V0S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

13616:PSMB7
gene id: 13616:PSMB7
uniprot id: F6WNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:FKTN
gene id: 13616:FKTN
uniprot id: A0A5F8GS61
uniprot id: F7EQC4
names: Similarity
messages: Belongs to the LicD transferase family.

13616:LOC100025731
gene id: 13616:LOC100025731
uniprot id: A0A5F8H5M6
names: Similarity
messages: Belongs to the MHC class I family.

13616:PDGFC
gene id: 13616:PDGFC
uniprot id: F6XG94
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ARMC8
gene id: 13616:ARMC8
uniprot id: A0A5F8H532
uniprot id: A0A5F8HHK5
uniprot id: F7G243
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:SLC2A3
gene id: 13616:SLC2A3
uniprot id: F7BV22
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:NDFIP2
gene id: 13616:NDFIP2
uniprot id: F6QMS0
names: Subcellular Location Annotation
messages: Membrane

13616:GINS2
gene id: 13616:GINS2
uniprot id: F6Y4K0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

13616:VPS26A
gene id: 13616:VPS26A
uniprot id: A0A5F8G404
uniprot id: A0A5F8H0R3
uniprot id: H9H6E3
names: Similarity
messages: Belongs to the VPS26 family.

13616:GIMAP5
gene id: 13616:GIMAP5
uniprot id: A0A5F8GLW8
uniprot id: A0A5F8HKN7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:LOC103103310
gene id: 13616:LOC103103310
uniprot id: F6XQY4
names: Subcellular Location Annotation
messages: Cytoplasm

13616:OGG1
gene id: 13616:OGG1
uniprot id: F6ZEE7
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

13616:MC3R
gene id: 13616:MC3R
uniprot id: F6XQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

13616:SLC7A9
gene id: 13616:SLC7A9
uniprot id: F6YGR8
names: Subcellular Location Annotation
messages: Membrane

13616:LAMB3
gene id: 13616:LAMB3
uniprot id: F7BVU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:DGLUCY
gene id: 13616:DGLUCY
uniprot id: F7G523
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

13616:NSUN6
gene id: 13616:NSUN6
uniprot id: F7FNT7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100015438
gene id: 13616:LOC100015438
uniprot id: H9H6T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

13616:GALR3
gene id: 13616:GALR3
uniprot id: A0A5F8G583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:PAQR9
gene id: 13616:PAQR9
uniprot id: F7DX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:BDKRB2
gene id: 13616:BDKRB2
uniprot id: A0A5F8H7W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

13616:AP3B1
gene id: 13616:AP3B1
uniprot id: A0A5F8GK69
uniprot id: F6X3Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

13616:EPHA1
gene id: 13616:EPHA1
uniprot id: F7APP4
names: Subcellular Location Annotation
messages: Membrane

13616:KCNJ4
gene id: 13616:KCNJ4
uniprot id: H9H728
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:IRF1
gene id: 13616:IRF1
uniprot id: F6RS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

13616:CTC1
gene id: 13616:CTC1
uniprot id: F7EB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

13616:RNF43
gene id: 13616:RNF43
uniprot id: F7D310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

13616:FES
gene id: 13616:FES
uniprot id: F6RWR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

13616:FMR1
gene id: 13616:FMR1
uniprot id: A0A5F8GMX8
uniprot id: A0A5F8GRP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

13616:TMEM123
gene id: 13616:TMEM123
uniprot id: F7GG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

13616:LOC100033060
gene id: 13616:LOC100033060
uniprot id: F6UUX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:T2R25
gene id: 13616:T2R25
uniprot id: Q2AB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:ELMO3
gene id: 13616:ELMO3
uniprot id: F7E1P5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

13616:HTR1F
gene id: 13616:HTR1F
uniprot id: A0A5F8H0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

13616:VOPP1
gene id: 13616:VOPP1
uniprot id: K7E261
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Interacts with WWOX (via WW domain).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

13616:HARBI1
gene id: 13616:HARBI1
uniprot id: F6W684
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

13616:TMED10
gene id: 13616:TMED10
uniprot id: F6WFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:EVC
gene id: 13616:EVC
uniprot id: F6X0A2
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

13616:SMAD6
gene id: 13616:SMAD6
uniprot id: F6RFA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100027547
gene id: 13616:LOC100027547
uniprot id: F7B9C2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TENT5A
gene id: 13616:TENT5A
uniprot id: F6VNK9
names: Similarity
messages: Belongs to the TENT family.

13616:ASPM
gene id: 13616:ASPM
uniprot id: A0A5F8G5R4
uniprot id: F6VH23
names: Subcellular Location Annotation
messages: Nucleus

13616:TBCCD1
gene id: 13616:TBCCD1
uniprot id: F6ZJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

13616:LOC100026375
gene id: 13616:LOC100026375
uniprot id: F7ACW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:FAM149B1
gene id: 13616:FAM149B1
uniprot id: A0A5F8H0L5
names: Similarity
messages: Belongs to the FAM149 family.

13616:ACKR4
gene id: 13616:ACKR4
uniprot id: F7GHG6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100618164
gene id: 13616:LOC100618164
uniprot id: A0A5F8GKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

13616:USP39
gene id: 13616:USP39
uniprot id: F7FEM4
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM136A
gene id: 13616:FAM136A
uniprot id: F6QXV8
names: Similarity
messages: Belongs to the FAM136 family.

13616:SLC45A3
gene id: 13616:SLC45A3
uniprot id: F6T5F9
names: Subcellular Location Annotation
messages: Membrane

13616:ADRA1B
gene id: 13616:ADRA1B
uniprot id: F7CKY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

13616:USP2
gene id: 13616:USP2
uniprot id: F7EVY5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:GSTCD
gene id: 13616:GSTCD
uniprot id: F6ZAN7
names: Similarity
messages: Belongs to the GSTCD family.

13616:GDPGP1
gene id: 13616:GDPGP1
uniprot id: A0A5F8GEL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

13616:CDC42
gene id: 13616:CDC42
uniprot id: A0A5F8GY66
uniprot id: F7A567
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

13616:MLST8
gene id: 13616:MLST8
uniprot id: F6ZQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

13616:SNRPG
gene id: 13616:SNRPG
uniprot id: F6RHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

13616:PIK3C2B
gene id: 13616:PIK3C2B
uniprot id: F7BBM1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

13616:DUOXA1
gene id: 13616:DUOXA1
uniprot id: F7GG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

13616:PSMC1
gene id: 13616:PSMC1
uniprot id: F6Z7G5
names: Similarity
messages: Belongs to the AAA ATPase family.

13616:C3H8orf82
gene id: 13616:C3H8orf82
uniprot id: A0A5F8GQL4
names: Similarity
messages: Belongs to the UPF0598 family.

13616:MAGT1
gene id: 13616:MAGT1
uniprot id: F7G9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:RNASE4
gene id: 13616:RNASE4
uniprot id: F6QVB3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

13616:RNFT1
gene id: 13616:RNFT1
uniprot id: F6W4Q5
names: Subcellular Location Annotation
messages: Membrane

13616:CBS
gene id: 13616:CBS
uniprot id: A0A5F8G6S9
uniprot id: F6QYX0
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

13616:TGFBI
gene id: 13616:TGFBI
uniprot id: F7D796
names: Subcellular Location Annotation
messages: extracellular matrix

13616:LOC100020852
gene id: 13616:LOC100020852
uniprot id: A0A5F8GXB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CDCP2
gene id: 13616:CDCP2
uniprot id: A0A5F8HII6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100021121
gene id: 13616:LOC100021121
uniprot id: F7ANK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MRE11
gene id: 13616:MRE11
uniprot id: F6SYM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

13616:LOC100016373
gene id: 13616:LOC100016373
uniprot id: F7EBM0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

13616:KIF2C
gene id: 13616:KIF2C
uniprot id: A0A5F8GGD8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:HOXC6
gene id: 13616:HOXC6
uniprot id: A0A5F8HGN7
names: Subcellular Location Annotation
messages: Nucleus

13616:GPR17
gene id: 13616:GPR17
uniprot id: F6UCF6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:HMGB1
gene id: 13616:HMGB1
uniprot id: F7EDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

13616:SLC44A3
gene id: 13616:SLC44A3
uniprot id: A0A5F8HFL5
uniprot id: F6RTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

13616:PCNX2
gene id: 13616:PCNX2
uniprot id: F7CC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

13616:BMX
gene id: 13616:BMX
uniprot id: A0A5F8HHY8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:CHMP5
gene id: 13616:CHMP5
uniprot id: A0A5F8GSW5
names: Similarity
messages: Belongs to the SNF7 family.

13616:ING5
gene id: 13616:ING5
uniprot id: F6PGK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

13616:LOC100020685
gene id: 13616:LOC100020685
uniprot id: F7A114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ST6GALNAC4
gene id: 13616:ST6GALNAC4
uniprot id: A0A5F8GYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:TBR1
gene id: 13616:TBR1
uniprot id: F6YLI5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:TBX18
gene id: 13616:TBX18
uniprot id: F6PPW8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:HDAC9
gene id: 13616:HDAC9
uniprot id: F7BC62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

13616:MAT2B
gene id: 13616:MAT2B
uniprot id: A0A5F8GXJ5
uniprot id: F7C5P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

13616:NDUFB9
gene id: 13616:NDUFB9
uniprot id: A0A5F8HCS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:EIF5A
gene id: 13616:EIF5A
uniprot id: F7G3Z4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

13616:SASS6
gene id: 13616:SASS6
uniprot id: F7FAN2
names: Subcellular Location Annotation
messages: centrosome

13616:HSPB2
gene id: 13616:HSPB2
uniprot id: F7ATU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

13616:LOC100014039
gene id: 13616:LOC100014039
uniprot id: F6UNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

13616:GYS2
gene id: 13616:GYS2
uniprot id: F7CFJ9
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

13616:ITGA11
gene id: 13616:ITGA11
uniprot id: F7C5G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:MTX1
gene id: 13616:MTX1
uniprot id: F6V427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:PHF5A
gene id: 13616:PHF5A
uniprot id: H9H6Z1
names: Similarity
messages: Belongs to the PHF5 family.

13616:RIF1
gene id: 13616:RIF1
uniprot id: F7FA78
uniprot id: K7E160
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

13616:P3H3
gene id: 13616:P3H3
uniprot id: F7CXE1
names: Similarity
messages: Belongs to the leprecan family.

13616:MEF2A
gene id: 13616:MEF2A
uniprot id: A0A5F8GL01
uniprot id: A0A5F8GN96
uniprot id: F6THZ2
names: Subcellular Location Annotation
messages: Nucleus

13616:TDO2
gene id: 13616:TDO2
uniprot id: F6S7Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100024696
gene id: 13616:LOC100024696
uniprot id: F6PN14
names: Similarity
messages: Belongs to the serpin family.

13616:CRHBP
gene id: 13616:CRHBP
uniprot id: F6WNR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

13616:LOC100616785
gene id: 13616:LOC100616785
uniprot id: F7ER49
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:LOC103093588
gene id: 13616:LOC103093588
uniprot id: A0A5F8GQM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ENPEP
gene id: 13616:ENPEP
uniprot id: F6TL25
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

13616:LOC100011820
gene id: 13616:LOC100011820
uniprot id: K7E1T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100030384
gene id: 13616:LOC100030384
uniprot id: F7F1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HIGD1B
gene id: 13616:HIGD1B
uniprot id: F6T5E4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

13616:DENND11
gene id: 13616:DENND11
uniprot id: F6VF55
names: Similarity
messages: Belongs to the DENND11 family.

13616:FGD5
gene id: 13616:FGD5
uniprot id: F6RZS2
names: Subcellular Location Annotation
messages: cytoskeleton

13616:CHST4
gene id: 13616:CHST4
uniprot id: F7EX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:XPNPEP1
gene id: 13616:XPNPEP1
uniprot id: F7C1J9
names: Similarity
messages: Belongs to the peptidase M24B family.

13616:DLL1
gene id: 13616:DLL1
uniprot id: F7CZU6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

13616:PHYHIPL
gene id: 13616:PHYHIPL
uniprot id: F7EAV9
names: Similarity
messages: Belongs to the PHYHIP family.

13616:MZT2B
gene id: 13616:MZT2B
uniprot id: F6V599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

13616:MOS
gene id: 13616:MOS
uniprot id: F6RB09
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:TAF5
gene id: 13616:TAF5
uniprot id: F7DL63
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

13616:PABPC1L
gene id: 13616:PABPC1L
uniprot id: A0A5F8H1R1
uniprot id: F6TY24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

13616:PANX3
gene id: 13616:PANX3
uniprot id: A0A5F8GYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

13616:LOC100029967
gene id: 13616:LOC100029967
uniprot id: F6W190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

13616:MED14
gene id: 13616:MED14
uniprot id: F6UIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

13616:SLC20A1
gene id: 13616:SLC20A1
uniprot id: A0A5F8GIH0
uniprot id: F6VT24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

13616:STMN4
gene id: 13616:STMN4
uniprot id: A0A5F8GBD4
uniprot id: F6ZRY0
names: Similarity
messages: Belongs to the stathmin family.

13616:NDFIP1
gene id: 13616:NDFIP1
uniprot id: F7AV91
names: Subcellular Location Annotation
messages: Membrane

13616:PGC
gene id: 13616:PGC
uniprot id: Q689Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds.
messages: Secreted

13616:TXNRD3
gene id: 13616:TXNRD3
uniprot id: F7FNP7
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

13616:LOC100013946
gene id: 13616:LOC100013946
uniprot id: F7D009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

13616:RETREG1
gene id: 13616:RETREG1
uniprot id: A0A5F8G5W0
uniprot id: A0A5F8G7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:S100Z
gene id: 13616:S100Z
uniprot id: F6WNQ1
names: Similarity
messages: Belongs to the S-100 family.

13616:LDB1
gene id: 13616:LDB1
uniprot id: A0A5F8GEZ5
uniprot id: F6V1M4
names: Similarity
messages: Belongs to the LDB family.

13616:LOC100012347
gene id: 13616:LOC100012347
uniprot id: A0A5F8HH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100027300
gene id: 13616:LOC100027300
uniprot id: F6V138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

13616:SYNCRIP
gene id: 13616:SYNCRIP
uniprot id: A0A5F8G264
names: Subcellular Location Annotation
messages: Cytoplasm

13616:ABCG1
gene id: 13616:ABCG1
uniprot id: F6QZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:ATP1B2
gene id: 13616:ATP1B2
uniprot id: F7FQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

13616:EFTUD2
gene id: 13616:EFTUD2
uniprot id: F7D3I7
names: Subcellular Location Annotation
messages: Nucleus

13616:TIMM44
gene id: 13616:TIMM44
uniprot id: F7ASY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

13616:SLC7A13
gene id: 13616:SLC7A13
uniprot id: F7AJ24
names: Subcellular Location Annotation
messages: Membrane

13616:CRKL
gene id: 13616:CRKL
uniprot id: F6Z4K4
names: Similarity
messages: Belongs to the CRK family.

13616:LOC100030460
gene id: 13616:LOC100030460
uniprot id: F6SHD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

13616:TIMM23B
gene id: 13616:TIMM23B
uniprot id: F7DI36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

13616:SPO11
gene id: 13616:SPO11
uniprot id: F6X8N3
names: Similarity
messages: Belongs to the TOP6A family.

13616:KHDRBS2
gene id: 13616:KHDRBS2
uniprot id: F7FCC7
names: Similarity
messages: Belongs to the KHDRBS family.

13616:THAP1
gene id: 13616:THAP1
uniprot id: F6XLQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

13616:LOC100026196
gene id: 13616:LOC100026196
uniprot id: F6YF10
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:PPARGC1A
gene id: 13616:PPARGC1A
uniprot id: F6XM07
names: Subcellular Location Annotation
messages: PML body

13616:YWHAB
gene id: 13616:YWHAB
uniprot id: A0A5F8GSA5
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:FAM20B
gene id: 13616:FAM20B
uniprot id: F7FSJ9
names: Similarity
messages: Belongs to the FAM20 family.

13616:SLC16A2
gene id: 13616:SLC16A2
uniprot id: H9H6J2
names: Subcellular Location Annotation
messages: Membrane

13616:SH3BP4
gene id: 13616:SH3BP4
uniprot id: F7E2A9
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

13616:LOC103094087
gene id: 13616:LOC103094087
uniprot id: A0A5F8GN60
names: Similarity
messages: Belongs to the Speedy/Ringo family.

13616:TXNDC5
gene id: 13616:TXNDC5
uniprot id: A0A5F8H2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:PCSK1
gene id: 13616:PCSK1
uniprot id: F7GI61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

13616:FXR2
gene id: 13616:FXR2
uniprot id: F6XS15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Postsynapse
messages: Synapse

13616:DGAT1
gene id: 13616:DGAT1
uniprot id: F7C164
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

13616:BLM
gene id: 13616:BLM
uniprot id: F6RXI0
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

13616:RPS19BP1
gene id: 13616:RPS19BP1
uniprot id: A0A5F8GRV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

13616:ID3
gene id: 13616:ID3
uniprot id: A0A5F8HA76
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC25A44
gene id: 13616:SLC25A44
uniprot id: F6VN60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:PHC3
gene id: 13616:PHC3
uniprot id: F7FZ58
names: Subcellular Location Annotation
messages: Nucleus

13616:FAM76B
gene id: 13616:FAM76B
uniprot id: A0A5F8G5E9
names: Similarity
messages: Belongs to the FAM76 family.

13616:DYRK3
gene id: 13616:DYRK3
uniprot id: F6UZJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

13616:LOC100028170
gene id: 13616:LOC100028170
uniprot id: A0A5F8G805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100013379
gene id: 13616:LOC100013379
uniprot id: A0A5F8GLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:ATOSA
gene id: 13616:ATOSA
uniprot id: F6T5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

13616:SLC46A3
gene id: 13616:SLC46A3
uniprot id: F7B0M8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100012527
gene id: 13616:LOC100012527
uniprot id: F6UY50
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

13616:DVL1
gene id: 13616:DVL1
uniprot id: F7G276
names: Similarity
messages: Belongs to the DSH family.

13616:TGIF1
gene id: 13616:TGIF1
uniprot id: A0A5F8HH57
names: Subcellular Location Annotation
messages: Nucleus

13616:COQ7
gene id: 13616:COQ7
uniprot id: F7B5L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

13616:SNX11
gene id: 13616:SNX11
uniprot id: A0A5F8HJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

13616:NSF
gene id: 13616:NSF
uniprot id: F7F4B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

13616:MAML1
gene id: 13616:MAML1
uniprot id: F7GAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

13616:CHFR
gene id: 13616:CHFR
uniprot id: F6TMI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

13616:APOH
gene id: 13616:APOH
uniprot id: F6QPV8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:MOCS3
gene id: 13616:MOCS3
uniprot id: F6XRW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

13616:LAMTOR2
gene id: 13616:LAMTOR2
uniprot id: F6V5I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

13616:monDomV1R1210
gene id: 13616:monDomV1R1210
uniprot id: A0A5F8GVP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016866
gene id: 13616:LOC100016866
uniprot id: A0A5F8G341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NHSL1
gene id: 13616:NHSL1
uniprot id: A0A5F8HHA7
uniprot id: F6SKV8
names: Similarity
messages: Belongs to the NHS family.

13616:FAM131C
gene id: 13616:FAM131C
uniprot id: A0A5F8HLV3
names: Similarity
messages: Belongs to the FAM131 family.

13616:EMSY
gene id: 13616:EMSY
uniprot id: A0A5F8GFH5
uniprot id: A0A5F8GY23
uniprot id: A0A5F8H3J3
uniprot id: A0A5F8HI90
uniprot id: F7DM87
names: Subcellular Location Annotation
messages: Nucleus

13616:WNT5B
gene id: 13616:WNT5B
uniprot id: A0A5F8GU38
uniprot id: A0A5F8HJT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:ATP6V1B2
gene id: 13616:ATP6V1B2
uniprot id: F6RX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

13616:PNLDC1
gene id: 13616:PNLDC1
uniprot id: A0A5F8GHL9
uniprot id: F7EE59
names: Similarity
messages: Belongs to the CAF1 family.

13616:RPL18A
gene id: 13616:RPL18A
uniprot id: A0A5F8H1R7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

13616:BARX1
gene id: 13616:BARX1
uniprot id: F6PVA4
names: Subcellular Location Annotation
messages: Nucleus

13616:OSBPL9
gene id: 13616:OSBPL9
uniprot id: A0A5F8GHN5
uniprot id: A0A5F8GUV3
uniprot id: F7F7Y5
names: Similarity
messages: Belongs to the OSBP family.

13616:QTRT2
gene id: 13616:QTRT2
uniprot id: A0A5F8GPI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

13616:STK17B
gene id: 13616:STK17B
uniprot id: F7FU71
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:MRPL44
gene id: 13616:MRPL44
uniprot id: A0A5F8G5S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

13616:GALT
gene id: 13616:GALT
uniprot id: F6YSD0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

13616:C1H19orf12
gene id: 13616:C1H19orf12
uniprot id: F6UYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

13616:ZDHHC23
gene id: 13616:ZDHHC23
uniprot id: F7CCF4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:RHBDL2
gene id: 13616:RHBDL2
uniprot id: A0A5F8GK43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

13616:NDUFS4
gene id: 13616:NDUFS4
uniprot id: A0A5F8G9C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

13616:ZDHHC6
gene id: 13616:ZDHHC6
uniprot id: F6ST88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:LOC100030059
gene id: 13616:LOC100030059
uniprot id: A0A5F8GKQ1
names: Subcellular Location Annotation
messages: Membrane

13616:IPO7
gene id: 13616:IPO7
uniprot id: F7ETD3
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PDGFD
gene id: 13616:PDGFD
uniprot id: F7F7V7
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:GLCE
gene id: 13616:GLCE
uniprot id: A0A5F8G9F3
uniprot id: A0A5F8GB43
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

13616:EGFL6
gene id: 13616:EGFL6
uniprot id: F6WWJ4
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TIMM10
gene id: 13616:TIMM10
uniprot id: F7ESA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

13616:PARP3
gene id: 13616:PARP3
uniprot id: F7CBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

13616:SPDL1
gene id: 13616:SPDL1
uniprot id: F6UEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

13616:DPH5
gene id: 13616:DPH5
uniprot id: F6ZPK7
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

13616:MS4A5
gene id: 13616:MS4A5
uniprot id: A0A5F8G948
names: Similarity
messages: Belongs to the MS4A family.

13616:SLC9A9
gene id: 13616:SLC9A9
uniprot id: F6TJF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

13616:AVPR1A
gene id: 13616:AVPR1A
uniprot id: F6UMG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

13616:LOC100025196
gene id: 13616:LOC100025196
uniprot id: A0A5F8HF19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ZDHHC20
gene id: 13616:ZDHHC20
uniprot id: A0A5F8G2I7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:EN2
gene id: 13616:EN2
uniprot id: F7FKY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

13616:MMGT1
gene id: 13616:MMGT1
uniprot id: K7E534
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

13616:ANTXR1
gene id: 13616:ANTXR1
uniprot id: F7CVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

13616:LOC100015984
gene id: 13616:LOC100015984
uniprot id: H9H6E5
names: Similarity
messages: Belongs to the hexokinase family.

13616:SHFL
gene id: 13616:SHFL
uniprot id: F7F5S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Nucleus

13616:LOC100013050
gene id: 13616:LOC100013050
uniprot id: A0A5F8GT56
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

13616:LOC103099758
gene id: 13616:LOC103099758
uniprot id: F7GEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016791
gene id: 13616:LOC100016791
uniprot id: A0A5F8H5E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GLIPR1
gene id: 13616:GLIPR1
uniprot id: F7A3E5
names: Similarity
messages: Belongs to the CRISP family.

13616:LOC100025644
gene id: 13616:LOC100025644
uniprot id: A0A5F8HG58
names: Similarity
messages: Belongs to the 2-5A synthase family.

13616:CRYBA4
gene id: 13616:CRYBA4
uniprot id: F7CJE9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

13616:NSUN5
gene id: 13616:NSUN5
uniprot id: F6WS57
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

13616:GPR137B
gene id: 13616:GPR137B
uniprot id: F6Z9G0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

13616:CALHM1
gene id: 13616:CALHM1
uniprot id: F7F4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:AFG1L
gene id: 13616:AFG1L
uniprot id: A0A5F8GVS7
names: Similarity
messages: Belongs to the AFG1 ATPase family.

13616:DDIT4
gene id: 13616:DDIT4
uniprot id: F6S0G1
names: Similarity
messages: Belongs to the DDIT4 family.

13616:PHC2
gene id: 13616:PHC2
uniprot id: A0A5F8GER8
uniprot id: F6U443
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100028211
gene id: 13616:LOC100028211
uniprot id: F6QU09
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

13616:B4GALT4
gene id: 13616:B4GALT4
uniprot id: F7B788
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:MSL3
gene id: 13616:MSL3
uniprot id: F6WEX7
names: Subcellular Location Annotation
messages: Nucleus

13616:DIS3L
gene id: 13616:DIS3L
uniprot id: F6WT23
names: Similarity
messages: Belongs to the RNR ribonuclease family.

13616:LOC100009862
gene id: 13616:LOC100009862
uniprot id: F6PJY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100618822
gene id: 13616:LOC100618822
uniprot id: A0A5F8G951
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TMCC3
gene id: 13616:TMCC3
uniprot id: F7FTZ9
names: Similarity
messages: Belongs to the TEX28 family.

13616:CDC25A
gene id: 13616:CDC25A
uniprot id: F6W4M4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

13616:GPR6
gene id: 13616:GPR6
uniprot id: F6TRX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DPY19L4
gene id: 13616:DPY19L4
uniprot id: F6RDC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:OLFM3
gene id: 13616:OLFM3
uniprot id: A0A5F8G5Z1
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

13616:VN2R627
gene id: 13616:VN2R627
uniprot id: F6WGS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100016492
gene id: 13616:LOC100016492
uniprot id: A0A5F8GQZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100013374
gene id: 13616:LOC100013374
uniprot id: F6RSW7
names: Subcellular Location Annotation
messages: Nucleus speckle

13616:ITFG1
gene id: 13616:ITFG1
uniprot id: F6ZNY3
names: Similarity
messages: Belongs to the TIP family.

13616:DXO
gene id: 13616:DXO
uniprot id: F7BXD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

13616:LOC100013884
gene id: 13616:LOC100013884
uniprot id: F6TNB5
names: Similarity
messages: Belongs to the intermediate filament family.

13616:LOC100011666
gene id: 13616:LOC100011666
uniprot id: A0A5F8HEK6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:TADA2A
gene id: 13616:TADA2A
uniprot id: F7GFC2
names: Subcellular Location Annotation
messages: Nucleus

13616:CCDC90B
gene id: 13616:CCDC90B
uniprot id: F6R6U9
names: Similarity
messages: Belongs to the CCDC90 family.

13616:C8H2orf49
gene id: 13616:C8H2orf49
uniprot id: F7B9F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

13616:LAPTM4B
gene id: 13616:LAPTM4B
uniprot id: F6PFS7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

13616:SLIT2
gene id: 13616:SLIT2
uniprot id: F6W5I6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:SMOC2
gene id: 13616:SMOC2
uniprot id: A0A5F8G1V5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MNAT1
gene id: 13616:MNAT1
uniprot id: F6PG98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

13616:PFDN6
gene id: 13616:PFDN6
uniprot id: F6TRF6
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

13616:YWHAG
gene id: 13616:YWHAG
uniprot id: F6TY10
names: Similarity
messages: Belongs to the 14-3-3 family.

13616:ZER1
gene id: 13616:ZER1
uniprot id: F7EZJ5
names: Similarity
messages: Belongs to the zyg-11 family.

13616:HOGA1
gene id: 13616:HOGA1
uniprot id: A0A5F8GMB5
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

13616:LOC100017233
gene id: 13616:LOC100017233
uniprot id: F7BTC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

13616:CHD8
gene id: 13616:CHD8
uniprot id: F7FS88
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

13616:FUT7
gene id: 13616:FUT7
uniprot id: F6T3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

13616:ABCD1
gene id: 13616:ABCD1
uniprot id: F7F302
names: Subcellular Location Annotation
messages: Membrane

13616:COPG1
gene id: 13616:COPG1
uniprot id: F7F307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

13616:SMDT1
gene id: 13616:SMDT1
uniprot id: F6UFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

13616:PRKCH
gene id: 13616:PRKCH
uniprot id: F6PWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

13616:LIG4
gene id: 13616:LIG4
uniprot id: F6SA46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

13616:TRPC4
gene id: 13616:TRPC4
uniprot id: F6TA59
names: Subcellular Location Annotation
messages: Membrane

13616:LFNG
gene id: 13616:LFNG
uniprot id: F6YBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:HADHA
gene id: 13616:HADHA
uniprot id: F7FE46
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

13616:SNAPIN
gene id: 13616:SNAPIN
uniprot id: A0A5F8G8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

13616:JAG2
gene id: 13616:JAG2
uniprot id: A0A5F8GH40
uniprot id: F7D3A1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

13616:LOC100013504
gene id: 13616:LOC100013504
uniprot id: F7C1Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ITIH2
gene id: 13616:ITIH2
uniprot id: F7CI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

13616:TRAF6
gene id: 13616:TRAF6
uniprot id: F6SAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

13616:SNX6
gene id: 13616:SNX6
uniprot id: F7ERS0
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:CHST7
gene id: 13616:CHST7
uniprot id: F7AP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

13616:PRLR
gene id: 13616:PRLR
uniprot id: F7F6E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

13616:CLTB
gene id: 13616:CLTB
uniprot id: A0A5F8G6P9
uniprot id: F7DN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

13616:IRF2BP1
gene id: 13616:IRF2BP1
uniprot id: F7E0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

13616:SQSTM1
gene id: 13616:SQSTM1
uniprot id: A0A5F8GH66
uniprot id: F6ZJ90
names: Subcellular Location Annotation
messages: autophagosome

13616:RRS1
gene id: 13616:RRS1
uniprot id: F6UTP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

13616:HOXD8
gene id: 13616:HOXD8
uniprot id: A0A5F8HJA7
uniprot id: F7A9D3
names: Subcellular Location Annotation
messages: Nucleus

13616:ATOSB
gene id: 13616:ATOSB
uniprot id: F7EUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

13616:LOC100021021
gene id: 13616:LOC100021021
uniprot id: A0A5F8H686
uniprot id: F6Q138
names: Similarity
messages: Belongs to the HPF1 family.

13616:APLNR
gene id: 13616:APLNR
uniprot id: A0A5F8GZ79
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:C4H2orf76
gene id: 13616:C4H2orf76
uniprot id: A0A5F8H671
names: Similarity
messages: Belongs to the UPF0538 family.

13616:HHEX
gene id: 13616:HHEX
uniprot id: F7EGI1
names: Subcellular Location Annotation
messages: Nucleus

13616:ABCG5
gene id: 13616:ABCG5
uniprot id: F6X4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

13616:NELFCD
gene id: 13616:NELFCD
uniprot id: F6ZD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

13616:ABCB6
gene id: 13616:ABCB6
uniprot id: F6XYD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

13616:XRCC3
gene id: 13616:XRCC3
uniprot id: F7D6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

13616:TRIM3
gene id: 13616:TRIM3
uniprot id: F7FDA8
names: Similarity
messages: Belongs to the TRIM/RBCC family.

13616:STRIP2
gene id: 13616:STRIP2
uniprot id: F7E828
names: Similarity
messages: Belongs to the STRIP family.

13616:TRAPPC2L
gene id: 13616:TRAPPC2L
uniprot id: F7D8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

13616:UTP6
gene id: 13616:UTP6
uniprot id: F6ZIB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

13616:GALK1
gene id: 13616:GALK1
uniprot id: F7BKK7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

13616:AMDHD1
gene id: 13616:AMDHD1
uniprot id: F6Z9Z3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

13616:FMC1
gene id: 13616:FMC1
uniprot id: F6WS80
names: Similarity
messages: Belongs to the FMC1 family.

13616:GFOD2
gene id: 13616:GFOD2
uniprot id: A0A5F8GEG8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

13616:PSMA1
gene id: 13616:PSMA1
uniprot id: F7FBS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:HSP90B1
gene id: 13616:HSP90B1
uniprot id: F7DFT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

13616:MFSD4B
gene id: 13616:MFSD4B
uniprot id: A0A5F8H379
names: Subcellular Location Annotation
messages: Membrane

13616:MAU2
gene id: 13616:MAU2
uniprot id: F6RD67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

13616:LOC100024047
gene id: 13616:LOC100024047
uniprot id: A0A5F8G9Q1
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

13616:SNRPD1
gene id: 13616:SNRPD1
uniprot id: F7G2W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

13616:LOC100011074
gene id: 13616:LOC100011074
uniprot id: F7EGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VPS53
gene id: 13616:VPS53
uniprot id: F6WN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

13616:HOXA3
gene id: 13616:HOXA3
uniprot id: F7BGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:PELI1
gene id: 13616:PELI1
uniprot id: F6TZ95
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

13616:VMA21
gene id: 13616:VMA21
uniprot id: A0A5F8HG12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

13616:LOC100011028
gene id: 13616:LOC100011028
uniprot id: A0A5F8HF36
names: Subcellular Location Annotation
messages: Membrane

13616:UBAC2
gene id: 13616:UBAC2
uniprot id: A0A5F8HE64
names: Subcellular Location Annotation
messages: Membrane

13616:TRAK1
gene id: 13616:TRAK1
uniprot id: A0A5F8HIC1
uniprot id: A0A5F8HJA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

13616:CENPJ
gene id: 13616:CENPJ
uniprot id: F7EBI9
names: Similarity
messages: Belongs to the TCP10 family.

13616:LOC100010438
gene id: 13616:LOC100010438
uniprot id: F6TF19
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

13616:PLPBP
gene id: 13616:PLPBP
uniprot id: F7FW91
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

13616:VN2R641
gene id: 13616:VN2R641
uniprot id: F7C1B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100020362
gene id: 13616:LOC100020362
uniprot id: A0A5F8G9D4
names: Subcellular Location Annotation
messages: Nucleus

13616:VN2R653
gene id: 13616:VN2R653
uniprot id: F6ZT09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100032661
gene id: 13616:LOC100032661
uniprot id: F7FUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

13616:KIF22
gene id: 13616:KIF22
uniprot id: F6PIR6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:CDC14B
gene id: 13616:CDC14B
uniprot id: F6XN43
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

13616:HHAT
gene id: 13616:HHAT
uniprot id: F7FUH3
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100026277
gene id: 13616:LOC100026277
uniprot id: F6PG40
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:UXS1
gene id: 13616:UXS1
uniprot id: F7G4Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

13616:SRP54
gene id: 13616:SRP54
uniprot id: F7GC32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

13616:LHX4
gene id: 13616:LHX4
uniprot id: F7GCT5
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100618318
gene id: 13616:LOC100618318
uniprot id: F7AWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:AKAP5
gene id: 13616:AKAP5
uniprot id: F7FZI4
names: Subcellular Location Annotation
messages: Membrane

13616:CARTPT
gene id: 13616:CARTPT
uniprot id: F6T7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

13616:SLC9A6
gene id: 13616:SLC9A6
uniprot id: H9H7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

13616:TREH
gene id: 13616:TREH
uniprot id: F7D8S1
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

13616:CGAS
gene id: 13616:CGAS
uniprot id: F7GD20
names: Similarity
messages: Belongs to the mab-21 family.

13616:TMEM138
gene id: 13616:TMEM138
uniprot id: A0A5F8HAA5
uniprot id: A0A5F8HJB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

13616:DBX1
gene id: 13616:DBX1
uniprot id: F7FQV1
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100009897
gene id: 13616:LOC100009897
uniprot id: F6PJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100618871
gene id: 13616:LOC100618871
uniprot id: A0A5F8GGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC6A15
gene id: 13616:SLC6A15
uniprot id: F7F542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

13616:ORM1
gene id: 13616:ORM1
uniprot id: F7DTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

13616:LDLR
gene id: 13616:LDLR
uniprot id: F7BQZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:IL17RB
gene id: 13616:IL17RB
uniprot id: A0A5F8G9B2
uniprot id: F6Q0J4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100010091
gene id: 13616:LOC100010091
uniprot id: A0A5F8GMM8
names: Similarity
messages: Belongs to the sepiapterin reductase family.

13616:PPP2R5A
gene id: 13616:PPP2R5A
uniprot id: A0A5F8H6J6
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:TRMT2A
gene id: 13616:TRMT2A
uniprot id: F6S9Y2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TSPOAP1
gene id: 13616:TSPOAP1
uniprot id: A0A5F8GM78
uniprot id: A0A5F8GX99
uniprot id: F7E3H7
names: Similarity
messages: Belongs to the RIMBP family.

13616:B4GALT6
gene id: 13616:B4GALT6
uniprot id: A0A5F8GIY1
uniprot id: A0A5F8GVZ2
uniprot id: A0A5F8HAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:KMT5A
gene id: 13616:KMT5A
uniprot id: A0A5F8GBR1
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

13616:ABCB10
gene id: 13616:ABCB10
uniprot id: F7AF84
names: Subcellular Location Annotation
messages: Membrane

13616:VPS33A
gene id: 13616:VPS33A
uniprot id: F7CE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

13616:COPS8
gene id: 13616:COPS8
uniprot id: F7CRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

13616:PDS5A
gene id: 13616:PDS5A
uniprot id: F7AQ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

13616:SLC15A1
gene id: 13616:SLC15A1
uniprot id: F7EJN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

13616:EXOC4
gene id: 13616:EXOC4
uniprot id: F7C1U2
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

13616:NUTF2
gene id: 13616:NUTF2
uniprot id: F7G5K7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

13616:SLC8A3
gene id: 13616:SLC8A3
uniprot id: A0A5F8GZ84
uniprot id: A0A5F8H119
uniprot id: A0A5F8H3Q2
uniprot id: F7FC55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

13616:PRKG2
gene id: 13616:PRKG2
uniprot id: F6YKH9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

13616:POLR2D
gene id: 13616:POLR2D
uniprot id: F7B1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

13616:LOC100020935
gene id: 13616:LOC100020935
uniprot id: F7E5H4
names: Subcellular Location Annotation
messages: Membrane

13616:ADA2
gene id: 13616:ADA2
uniprot id: F7CUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

13616:ARSK
gene id: 13616:ARSK
uniprot id: F7ESB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

13616:CREG2
gene id: 13616:CREG2
uniprot id: A0A5F8H8C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

13616:LOC100023565
gene id: 13616:LOC100023565
uniprot id: F7EC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

13616:P4HA2
gene id: 13616:P4HA2
uniprot id: F6UQK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

13616:EPHA5
gene id: 13616:EPHA5
uniprot id: A0A5F8G8S7
uniprot id: F7ANR2
names: Subcellular Location Annotation
messages: Membrane

13616:PLXNC1
gene id: 13616:PLXNC1
uniprot id: F7C5U5
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100022942
gene id: 13616:LOC100022942
uniprot id: F7DG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MEF2D
gene id: 13616:MEF2D
uniprot id: A0A5F8GNZ6
uniprot id: A0A5F8GYJ9
uniprot id: A0A5F8GZI2
uniprot id: F7AJL0
names: Subcellular Location Annotation
messages: Nucleus

13616:DDIT4L
gene id: 13616:DDIT4L
uniprot id: F7DKS7
names: Similarity
messages: Belongs to the DDIT4 family.

13616:KCNH5
gene id: 13616:KCNH5
uniprot id: F7GL29
names: Subcellular Location Annotation
messages: Membrane

13616:CDC20B
gene id: 13616:CDC20B
uniprot id: F6RB64
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

13616:LDLRAD4
gene id: 13616:LDLRAD4
uniprot id: F7B2V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

13616:GTF2H5
gene id: 13616:GTF2H5
uniprot id: F7FNG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

13616:STXBP5
gene id: 13616:STXBP5
uniprot id: A0A5F8H8D5
uniprot id: F6Y2V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

13616:LOC100017350
gene id: 13616:LOC100017350
uniprot id: A0A5F8GHU6
uniprot id: A0A5F8H925
names: Subcellular Location Annotation
messages: Nucleus

13616:HDDC2
gene id: 13616:HDDC2
uniprot id: F7FUJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

13616:GTF2E1
gene id: 13616:GTF2E1
uniprot id: F6PGB5
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

13616:AREG
gene id: 13616:AREG
uniprot id: F7A8Y1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:NDC1
gene id: 13616:NDC1
uniprot id: H9H7Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

13616:MCM4
gene id: 13616:MCM4
uniprot id: F6SAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

13616:WDR83OS
gene id: 13616:WDR83OS
uniprot id: A0A5F8GXI5
names: Similarity
messages: Belongs to the Asterix family.

13616:FAM13B
gene id: 13616:FAM13B
uniprot id: A0A5F8GHS6
uniprot id: A0A5F8GN33
uniprot id: A0A5F8GTD7
uniprot id: F6YH59
names: Similarity
messages: Belongs to the FAM13 family.

13616:CCND3
gene id: 13616:CCND3
uniprot id: F7EFT1
names: Similarity
messages: Belongs to the cyclin family.

13616:CPLX3
gene id: 13616:CPLX3
uniprot id: F6YXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:ATP2C1
gene id: 13616:ATP2C1
uniprot id: A0A5F8H884
uniprot id: F7B938
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:XPC
gene id: 13616:XPC
uniprot id: F7FCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

13616:LOC100619033
gene id: 13616:LOC100619033
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:GJB4
gene id: 13616:GJB4
uniprot id: F7E348
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:monDomV1R1245
gene id: 13616:monDomV1R1245
uniprot id: A0A5F8HDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CHDH
gene id: 13616:CHDH
uniprot id: F6PZX9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

13616:LOC100013449
gene id: 13616:LOC100013449
uniprot id: F7FD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC103095228
gene id: 13616:LOC103095228
uniprot id: K7E2B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

13616:PKD2
gene id: 13616:PKD2
uniprot id: F7ANU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

13616:LOC100024002
gene id: 13616:LOC100024002
uniprot id: F7GDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CTSK
gene id: 13616:CTSK
uniprot id: A0A5F8H101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:GADD45GIP1
gene id: 13616:GADD45GIP1
uniprot id: F6QWU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

13616:RBP1
gene id: 13616:RBP1
uniprot id: F7BQ15
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:RTN4
gene id: 13616:RTN4
uniprot id: A0A5F8GRQ3
uniprot id: F6T5Z0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:MAEL
gene id: 13616:MAEL
uniprot id: A0A5F8HJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

13616:GOT1
gene id: 13616:GOT1
uniprot id: F7GBD3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

13616:STARD6
gene id: 13616:STARD6
uniprot id: F7EML9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

13616:EVC2
gene id: 13616:EVC2
uniprot id: F6XGD8
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

13616:TTR
gene id: 13616:TTR
uniprot id: P49141
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in plasma and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).
messages: Secreted
messages: Sulfonation of the reactive cysteine Cys-32 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

13616:LOC100016831
gene id: 13616:LOC100016831
uniprot id: F6Z632
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARSA
gene id: 13616:ARSA
uniprot id: F7FF08
names: Similarity
messages: Belongs to the sulfatase family.

13616:SNX2
gene id: 13616:SNX2
uniprot id: F6WI51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

13616:RCAN3
gene id: 13616:RCAN3
uniprot id: F7EXQ5
names: Similarity
messages: Belongs to the RCAN family.

13616:ZC3H14
gene id: 13616:ZC3H14
uniprot id: A0A5F8GUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

13616:SLC2A12
gene id: 13616:SLC2A12
uniprot id: F7F0U7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

13616:CHMP1A
gene id: 13616:CHMP1A
uniprot id: A0A5F8GJP3
names: Similarity
messages: Belongs to the SNF7 family.

13616:PPFIBP1
gene id: 13616:PPFIBP1
uniprot id: A0A5F8GGX5
uniprot id: A0A5F8GKV8
uniprot id: A0A5F8H946
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

13616:PRM1
gene id: 13616:PRM1
uniprot id: P67836
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

13616:ACYP1
gene id: 13616:ACYP1
uniprot id: F7AJT1
names: Similarity
messages: Belongs to the acylphosphatase family.

13616:BET1
gene id: 13616:BET1
uniprot id: A0A5F8HEH6
names: Subcellular Location Annotation
messages: Membrane

13616:NKX3-1
gene id: 13616:NKX3-1
uniprot id: F7G683
names: Subcellular Location Annotation
messages: Nucleus

13616:IFNGR1
gene id: 13616:IFNGR1
uniprot id: F7AIU8
names: Similarity
messages: Belongs to the type II cytokine receptor family.

13616:LIX1L
gene id: 13616:LIX1L
uniprot id: F7EF18
names: Similarity
messages: Belongs to the LIX1 family.

13616:RUNDC3B
gene id: 13616:RUNDC3B
uniprot id: A0A5F8GW55
uniprot id: A0A5F8H6Q4
uniprot id: F6VPC5
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

13616:VN2R556
gene id: 13616:VN2R556
uniprot id: F6T901
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:NDUFA8
gene id: 13616:NDUFA8
uniprot id: F6TTD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

13616:USP3
gene id: 13616:USP3
uniprot id: A0A5F8GHN6
uniprot id: F6ZBV9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:MPP1
gene id: 13616:MPP1
uniprot id: F7DAK5
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

13616:MRM1
gene id: 13616:MRM1
uniprot id: F7DZ27
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

13616:LITAF
gene id: 13616:LITAF
uniprot id: A0A5F8GAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

13616:NME4
gene id: 13616:NME4
uniprot id: A0A5F8H1F6
names: Similarity
messages: Belongs to the NDK family.

13616:CNOT2
gene id: 13616:CNOT2
uniprot id: A0A5F8GXH6
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

13616:RIPOR2
gene id: 13616:RIPOR2
uniprot id: F7FSX9
names: Similarity
messages: Belongs to the RIPOR family.

13616:LOC100025932
gene id: 13616:LOC100025932
uniprot id: A0A5F8G8X6
names: Similarity
messages: Belongs to the MHC class II family.

13616:AGPAT3
gene id: 13616:AGPAT3
uniprot id: F6W0F9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

13616:WDPCP
gene id: 13616:WDPCP
uniprot id: F6PP46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Membrane
messages: cilium axoneme

13616:FOXP1
gene id: 13616:FOXP1
uniprot id: F7E578
names: Subcellular Location Annotation
messages: Nucleus

13616:CLN8
gene id: 13616:CLN8
uniprot id: F6TRC3
names: Subcellular Location Annotation
messages: Membrane

13616:SLC5A10
gene id: 13616:SLC5A10
uniprot id: F7F7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:FUT9
gene id: 13616:FUT9
uniprot id: A0A5F8HBF0
uniprot id: F6U690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

13616:KCNJ8
gene id: 13616:KCNJ8
uniprot id: A0A5F8GX62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

13616:IL10
gene id: 13616:IL10
uniprot id: F6UHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

13616:SLC34A2
gene id: 13616:SLC34A2
uniprot id: F6VDR5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

13616:F12
gene id: 13616:F12
uniprot id: F6UQB2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:ATP6V0A1
gene id: 13616:ATP6V0A1
uniprot id: A0A5F8GWI7
uniprot id: F7GGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

13616:CASK
gene id: 13616:CASK
uniprot id: A0A5F8GLR6
uniprot id: A0A5F8GN34
names: Similarity
messages: Belongs to the MAGUK family.

13616:LOC100021720
gene id: 13616:LOC100021720
uniprot id: A0A5F8GNQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MCTP1
gene id: 13616:MCTP1
uniprot id: A0A5F8H5K8
uniprot id: A0A5F8H8W6
uniprot id: F7DQX5
names: Subcellular Location Annotation
messages: Membrane

13616:TCF7L2
gene id: 13616:TCF7L2
uniprot id: A0A5F8GZI9
uniprot id: F6WN21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

13616:VN2R657
gene id: 13616:VN2R657
uniprot id: H9H957
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:TNFSF12
gene id: 13616:TNFSF12
uniprot id: A0A5F8GKJ9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

13616:TMEM205
gene id: 13616:TMEM205
uniprot id: F7FGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

13616:LOC100021052
gene id: 13616:LOC100021052
uniprot id: F6RPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SERPINB11
gene id: 13616:SERPINB11
uniprot id: F7D0K5
names: Similarity
messages: Belongs to the serpin family.

13616:FOXD4
gene id: 13616:FOXD4
uniprot id: A0A5F8HBA9
names: Subcellular Location Annotation
messages: Nucleus

13616:WDR44
gene id: 13616:WDR44
uniprot id: F6WZP0
names: Subcellular Location Annotation
messages: trans-Golgi network

13616:RFFL
gene id: 13616:RFFL
uniprot id: A0A5F8G6E5
uniprot id: F7EC98
names: Subcellular Location Annotation
messages: Cell membrane

13616:ACAT1
gene id: 13616:ACAT1
uniprot id: F7EQ19
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:EMC4
gene id: 13616:EMC4
uniprot id: F6SR81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:DCN
gene id: 13616:DCN
uniprot id: F6Q8B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

13616:SLC30A1
gene id: 13616:SLC30A1
uniprot id: A0A5F8GW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

13616:IRF2
gene id: 13616:IRF2
uniprot id: F6SVQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

13616:PPP2R5E
gene id: 13616:PPP2R5E
uniprot id: F7FRM5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:LOC100031464
gene id: 13616:LOC100031464
uniprot id: F7F8D9
names: Subcellular Location Annotation
messages: Membrane

13616:CALY
gene id: 13616:CALY
uniprot id: F7ES78
names: Similarity
messages: Belongs to the NSG family.

13616:NPRL2
gene id: 13616:NPRL2
uniprot id: F7G4N3
names: Similarity
messages: Belongs to the NPR2 family.

13616:VARS1
gene id: 13616:VARS1
uniprot id: F7B9X7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:PFDN4
gene id: 13616:PFDN4
uniprot id: A0A5F8G255
uniprot id: F7E8R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

13616:SPIRE1
gene id: 13616:SPIRE1
uniprot id: A0A5F8GPS7
uniprot id: F7CBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

13616:LOC100019374
gene id: 13616:LOC100019374
uniprot id: F6Z4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016938
gene id: 13616:LOC100016938
uniprot id: A0A5F8GV92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:ATG4D
gene id: 13616:ATG4D
uniprot id: F6XG04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

13616:ATP9A
gene id: 13616:ATP9A
uniprot id: F7EQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:RPS27L
gene id: 13616:RPS27L
uniprot id: A0A5F8H0P7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

13616:PAF1
gene id: 13616:PAF1
uniprot id: F7F917
names: Similarity
messages: Belongs to the PAF1 family.

13616:IRAK2
gene id: 13616:IRAK2
uniprot id: F7AID5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

13616:CAVIN2
gene id: 13616:CAVIN2
uniprot id: F7G2V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

13616:PRDM13
gene id: 13616:PRDM13
uniprot id: F7FT76
names: Subcellular Location Annotation
messages: Nucleus

13616:AZIN1
gene id: 13616:AZIN1
uniprot id: F6T425
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

13616:CDK5RAP3
gene id: 13616:CDK5RAP3
uniprot id: F6PJH2
names: Similarity
messages: Belongs to the CDK5RAP3 family.

13616:HMGN1
gene id: 13616:HMGN1
uniprot id: F6S609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:LOC100027021
gene id: 13616:LOC100027021
uniprot id: A0A5F8H5J0
uniprot id: F7AFX2
names: Similarity
messages: Belongs to the COX20 family.

13616:PITX3
gene id: 13616:PITX3
uniprot id: A0A5F8HBX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

13616:PENK
gene id: 13616:PENK
uniprot id: A0A5F8GKD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

13616:LDHA
gene id: 13616:LDHA
uniprot id: Q9XT87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31.
messages: ISGylated.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

13616:MTMR9
gene id: 13616:MTMR9
uniprot id: F7GCP6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

13616:UFD1
gene id: 13616:UFD1
uniprot id: F6TB32
names: Similarity
messages: Belongs to the UFD1 family.

13616:monDomV1R1265
gene id: 13616:monDomV1R1265
uniprot id: F6V7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100016303
gene id: 13616:LOC100016303
uniprot id: A0A5F8HH76
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

13616:INHBA
gene id: 13616:INHBA
uniprot id: H9H613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

13616:TENM1
gene id: 13616:TENM1
uniprot id: A0A5F8HIW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:NDST2
gene id: 13616:NDST2
uniprot id: F6VAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

13616:LOC100033074
gene id: 13616:LOC100033074
uniprot id: H9H6B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATP5PD
gene id: 13616:ATP5PD
uniprot id: A0A5F8GEJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

13616:PLK1
gene id: 13616:PLK1
uniprot id: F7F258
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

13616:ACHE
gene id: 13616:ACHE
uniprot id: F7C2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

13616:TNIP2
gene id: 13616:TNIP2
uniprot id: F7D8K2
names: Subcellular Location Annotation
messages: Cytoplasm

13616:OPRM1
gene id: 13616:OPRM1
uniprot id: F7CDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

13616:MEF2C
gene id: 13616:MEF2C
uniprot id: A0A5F8GFY9
names: Subcellular Location Annotation
messages: Nucleus

13616:TMPRSS5
gene id: 13616:TMPRSS5
uniprot id: A0A5F8H3S0
uniprot id: F6TRE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:VIPAS39
gene id: 13616:VIPAS39
uniprot id: A0A5F8GFK5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

13616:DPF3
gene id: 13616:DPF3
uniprot id: A0A5F8GFT4
uniprot id: A0A5F8GGJ7
names: Similarity
messages: Belongs to the requiem/DPF family.

13616:CENPB
gene id: 13616:CENPB
uniprot id: F6WYF8
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103104714
gene id: 13616:LOC103104714
uniprot id: A0A5F8G703
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RWDD3
gene id: 13616:RWDD3
uniprot id: F6TEP4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

13616:TBC1D24
gene id: 13616:TBC1D24
uniprot id: A0A5F8GEM1
uniprot id: F6S4P5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

13616:KCNK12
gene id: 13616:KCNK12
uniprot id: F7DPG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:PCMTD2
gene id: 13616:PCMTD2
uniprot id: F6VKL8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

13616:EEF1AKMT2
gene id: 13616:EEF1AKMT2
uniprot id: F6SAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

13616:KCNA1
gene id: 13616:KCNA1
uniprot id: F7EBT4
names: Subcellular Location Annotation
messages: Membrane

13616:NR5A1
gene id: 13616:NR5A1
uniprot id: F6WNR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

13616:CCN3
gene id: 13616:CCN3
uniprot id: F7DSB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:YDJC
gene id: 13616:YDJC
uniprot id: F6YJB8
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

13616:CLN5
gene id: 13616:CLN5
uniprot id: A0A5F8HFZ6
names: Similarity
messages: Belongs to the CLN5 family.

13616:LOC100025151
gene id: 13616:LOC100025151
uniprot id: A0A5F8GMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC6A6
gene id: 13616:SLC6A6
uniprot id: K7E0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

13616:PTCD3
gene id: 13616:PTCD3
uniprot id: F7CQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

13616:B3GNT3
gene id: 13616:B3GNT3
uniprot id: F7BK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:EIF2AK3
gene id: 13616:EIF2AK3
uniprot id: F6QTD0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

13616:CD99
gene id: 13616:CD99
uniprot id: K7E4D1
names: Similarity
messages: Belongs to the CD99 family.

13616:NKIRAS1
gene id: 13616:NKIRAS1
uniprot id: F6YKR4
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

13616:GPRC5C
gene id: 13616:GPRC5C
uniprot id: A0A5F8HDM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:BOLA3
gene id: 13616:BOLA3
uniprot id: A0A5F8G267
names: Similarity
messages: Belongs to the BolA/IbaG family.

13616:CNNM2
gene id: 13616:CNNM2
uniprot id: A0A5F8GKR4
uniprot id: A0A5F8H6Z0
uniprot id: F6ZZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

13616:SCNN1G
gene id: 13616:SCNN1G
uniprot id: F6Q7G2
names: Subcellular Location Annotation
messages: Membrane

13616:HSPA9
gene id: 13616:HSPA9
uniprot id: F7G4T9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

13616:KCNA7
gene id: 13616:KCNA7
uniprot id: A0A5F8GB06
names: Subcellular Location Annotation
messages: Membrane

13616:CAMLG
gene id: 13616:CAMLG
uniprot id: A0A5F8H8M1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

13616:TNFAIP6
gene id: 13616:TNFAIP6
uniprot id: F7C6K7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100619141
gene id: 13616:LOC100619141
uniprot id: F7ACA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GPR180
gene id: 13616:GPR180
uniprot id: F7GAZ5
names: Subcellular Location Annotation
messages: Membrane

13616:SMN1
gene id: 13616:SMN1
uniprot id: F7BCE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

13616:ABI2
gene id: 13616:ABI2
uniprot id: A0A5F8G218
uniprot id: A0A5F8GEI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

13616:CEBPE
gene id: 13616:CEBPE
uniprot id: F6QJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:VN2R624
gene id: 13616:VN2R624
uniprot id: A0A5F8H261
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:QSOX2
gene id: 13616:QSOX2
uniprot id: F7E0U9
names: Caution
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MINDY1
gene id: 13616:MINDY1
uniprot id: F7GKG5
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

13616:CRX
gene id: 13616:CRX
uniprot id: A0A5F8GF02
names: Subcellular Location Annotation
messages: Nucleus

13616:DNTTIP2
gene id: 13616:DNTTIP2
uniprot id: F6X146
names: Subcellular Location Annotation
messages: nucleolus

13616:NFU1
gene id: 13616:NFU1
uniprot id: F7CBJ3
names: Similarity
messages: Belongs to the NifU family.

13616:RIMKLB
gene id: 13616:RIMKLB
uniprot id: F7B7U4
names: Similarity
messages: Belongs to the RimK family.

13616:B4GALT3
gene id: 13616:B4GALT3
uniprot id: F6ZCN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

13616:DYNC1LI1
gene id: 13616:DYNC1LI1
uniprot id: F6V4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

13616:HGD
gene id: 13616:HGD
uniprot id: F6PGC2
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

13616:LOC100028638
gene id: 13616:LOC100028638
uniprot id: F7FSN0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

13616:LOC100010054
gene id: 13616:LOC100010054
uniprot id: F7EIS0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:ACVR1C
gene id: 13616:ACVR1C
uniprot id: F6SV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

13616:NR2E3
gene id: 13616:NR2E3
uniprot id: F6VJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:PROM1
gene id: 13616:PROM1
uniprot id: A0A5F8GWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

13616:FXN
gene id: 13616:FXN
uniprot id: F6PJV5
names: Similarity
messages: Belongs to the frataxin family.

13616:TMEM229B
gene id: 13616:TMEM229B
uniprot id: F7FLF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

13616:PPP2CA
gene id: 13616:PPP2CA
uniprot id: F6U7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

13616:VN2R645
gene id: 13616:VN2R645
uniprot id: F7BFX0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:INSIG1
gene id: 13616:INSIG1
uniprot id: F6US22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

13616:LOC100032863
gene id: 13616:LOC100032863
uniprot id: F6TG00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

13616:KDSR
gene id: 13616:KDSR
uniprot id: F7GGW4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:CAVIN1
gene id: 13616:CAVIN1
uniprot id: F7BYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

13616:LOC100010349
gene id: 13616:LOC100010349
uniprot id: F7FWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

13616:VN2R598
gene id: 13616:VN2R598
uniprot id: F7FK66
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:PYY
gene id: 13616:PYY
uniprot id: F7GDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

13616:LOC100015365
gene id: 13616:LOC100015365
uniprot id: A0A5F8G632
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

13616:CDA
gene id: 13616:CDA
uniprot id: F7FRF9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

13616:LOC100030375
gene id: 13616:LOC100030375
uniprot id: A0A5F8H3W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:NAA38
gene id: 13616:NAA38
uniprot id: A0A5F8GTX9
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

13616:PPP2R5D
gene id: 13616:PPP2R5D
uniprot id: F7C5Z9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

13616:CRELD2
gene id: 13616:CRELD2
uniprot id: F6Z426
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MXRA8
gene id: 13616:MXRA8
uniprot id: F7FD57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:VN2R588
gene id: 13616:VN2R588
uniprot id: A0A5F8GQR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:monDomV1R1205
gene id: 13616:monDomV1R1205
uniprot id: A0A5F8GU84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ASF1A
gene id: 13616:ASF1A
uniprot id: A0A5F8H323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

13616:ATP1B4
gene id: 13616:ATP1B4
uniprot id: F6SSM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

13616:SNX13
gene id: 13616:SNX13
uniprot id: F7APQ1
names: Similarity
messages: Belongs to the sorting nexin family.

13616:LOC100015907
gene id: 13616:LOC100015907
uniprot id: F7CIV5
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

13616:VN2R554
gene id: 13616:VN2R554
uniprot id: A0A5F8GWZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100009821
gene id: 13616:LOC100009821
uniprot id: F7ARS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity).
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

13616:PPIP5K1
gene id: 13616:PPIP5K1
uniprot id: A0A5F8GQ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

13616:BBOX1
gene id: 13616:BBOX1
uniprot id: F7BLG7
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

13616:APOOL
gene id: 13616:APOOL
uniprot id: F6V4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

13616:LOC100020352
gene id: 13616:LOC100020352
uniprot id: F6ZKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:DYDC1
gene id: 13616:DYDC1
uniprot id: F7EMW4
names: Similarity
messages: Belongs to the dpy-30 family.

13616:HNF1B
gene id: 13616:HNF1B
uniprot id: F7F998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

13616:TIMM50
gene id: 13616:TIMM50
uniprot id: F7AVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

13616:KHDRBS1
gene id: 13616:KHDRBS1
uniprot id: F7E0Y6
names: Similarity
messages: Belongs to the KHDRBS family.

13616:NSG2
gene id: 13616:NSG2
uniprot id: F6SKF7
names: Similarity
messages: Belongs to the NSG family.

13616:DLGAP1
gene id: 13616:DLGAP1
uniprot id: A0A5F8GKA2
uniprot id: A0A5F8GWZ2
uniprot id: A0A5F8H5G5
names: Similarity
messages: Belongs to the SAPAP family.

13616:ARPP19
gene id: 13616:ARPP19
uniprot id: F6T5G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

13616:SLC22A3
gene id: 13616:SLC22A3
uniprot id: F7BTT8
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

13616:DUT
gene id: 13616:DUT
uniprot id: F7CYM7
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

13616:LOC100618906
gene id: 13616:LOC100618906
uniprot id: F7DM99
names: Subcellular Location Annotation
messages: Membrane

13616:EFEMP1
gene id: 13616:EFEMP1
uniprot id: A0A5F8GD15
uniprot id: F6RHE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TMEFF1
gene id: 13616:TMEFF1
uniprot id: F7CTI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LAMP2
gene id: 13616:LAMP2
uniprot id: F6W221
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

13616:CCDC103
gene id: 13616:CCDC103
uniprot id: F6WJE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

13616:LOC100021277
gene id: 13616:LOC100021277
uniprot id: F7FVT0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

13616:LOC100032985
gene id: 13616:LOC100032985
uniprot id: A0A5F8HHH3
uniprot id: F6PKA9
uniprot id: F6PNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

13616:TUBB6
gene id: 13616:TUBB6
uniprot id: F7CB79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:DARS1
gene id: 13616:DARS1
uniprot id: F6YRH4
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

13616:TUT1
gene id: 13616:TUT1
uniprot id: F7EVE8
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

13616:NOL8
gene id: 13616:NOL8
uniprot id: H9H7P4
names: Subcellular Location Annotation
messages: nucleolus

13616:TLN2
gene id: 13616:TLN2
uniprot id: F6WZR8
names: Subcellular Location Annotation
messages: cytoskeleton

13616:TAF12
gene id: 13616:TAF12
uniprot id: A0A5F8GBI8
uniprot id: A0A5F8HHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

13616:STRN3
gene id: 13616:STRN3
uniprot id: F7BS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

13616:KCNJ2
gene id: 13616:KCNJ2
uniprot id: F7F885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

13616:TNFRSF11A
gene id: 13616:TNFRSF11A
uniprot id: F7AS58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CLP1
gene id: 13616:CLP1
uniprot id: F6U3G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

13616:LOC100018815
gene id: 13616:LOC100018815
uniprot id: A0A5F8H720
names: Subcellular Location Annotation
messages: Membrane

13616:CEBPZ
gene id: 13616:CEBPZ
uniprot id: F6ZXT1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

13616:LOC100020228
gene id: 13616:LOC100020228
uniprot id: F7F450
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

13616:LOC100020089
gene id: 13616:LOC100020089
uniprot id: F7DCB3
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

13616:MOSPD1
gene id: 13616:MOSPD1
uniprot id: A0A5F8HJ15
uniprot id: F7BWH5
names: Subcellular Location Annotation
messages: Membrane

13616:POLR2M
gene id: 13616:POLR2M
uniprot id: F7GET9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

13616:PTK6
gene id: 13616:PTK6
uniprot id: F6Y152
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

13616:USP44
gene id: 13616:USP44
uniprot id: F7ELW8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

13616:LOC100028103
gene id: 13616:LOC100028103
uniprot id: A0A5F8GP87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

13616:GTF2A1
gene id: 13616:GTF2A1
uniprot id: F7EVS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

13616:PARP2
gene id: 13616:PARP2
uniprot id: F6RCB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

13616:ACO2
gene id: 13616:ACO2
uniprot id: A0A5F8GFB5
uniprot id: H9H6Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

13616:RALY
gene id: 13616:RALY
uniprot id: F7EJ60
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

13616:B3GALT1
gene id: 13616:B3GALT1
uniprot id: F7FAR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

13616:LOC100010993
gene id: 13616:LOC100010993
uniprot id: F6SVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

13616:TPPP2
gene id: 13616:TPPP2
uniprot id: A0A5F8G683
names: Similarity
messages: Belongs to the TPPP family.

13616:ADGRL2
gene id: 13616:ADGRL2
uniprot id: A0A5F8GKV4
names: Subcellular Location Annotation
messages: Membrane

13616:MAST3
gene id: 13616:MAST3
uniprot id: F6VY61
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

13616:AMOTL2
gene id: 13616:AMOTL2
uniprot id: F7B3K2
names: Similarity
messages: Belongs to the angiomotin family.

13616:TMEM161A
gene id: 13616:TMEM161A
uniprot id: F6VW04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

13616:LOC100031975
gene id: 13616:LOC100031975
uniprot id: F6TYS0
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:HMGCL
gene id: 13616:HMGCL
uniprot id: F6Z184
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

13616:NUCB2
gene id: 13616:NUCB2
uniprot id: F6XCE7
names: Similarity
messages: Belongs to the nucleobindin family.

13616:SCARB1
gene id: 13616:SCARB1
uniprot id: A0A5F8G9T3
uniprot id: A0A5F8G9U5
uniprot id: A0A5F8HKB3
names: Similarity
messages: Belongs to the CD36 family.

13616:RPS12
gene id: 13616:RPS12
uniprot id: F7EIJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

13616:EDC3
gene id: 13616:EDC3
uniprot id: A0A5F8G2Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

13616:KRT36
gene id: 13616:KRT36
uniprot id: F7ER43
names: Similarity
messages: Belongs to the intermediate filament family.

13616:TUBB
gene id: 13616:TUBB
uniprot id: F7F082
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

13616:NDNF
gene id: 13616:NDNF
uniprot id: A0A5F8GTJ5
names: Subcellular Location Annotation
messages: Secreted

13616:FUNDC1
gene id: 13616:FUNDC1
uniprot id: A0A5F8H9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

13616:MMP27
gene id: 13616:MMP27
uniprot id: F6X261
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:E2F8
gene id: 13616:E2F8
uniprot id: F7B2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

13616:BAP1
gene id: 13616:BAP1
uniprot id: F6RI15
names: Similarity
messages: Belongs to the peptidase C12 family.

13616:STK40
gene id: 13616:STK40
uniprot id: F6ZXC1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

13616:T2R24
gene id: 13616:T2R24
uniprot id: Q2AB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:DPY19L3
gene id: 13616:DPY19L3
uniprot id: F7DHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

13616:LOC107648878
gene id: 13616:LOC107648878
uniprot id: A0A5F8GB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LPAR2
gene id: 13616:LPAR2
uniprot id: F6VRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GJB1
gene id: 13616:GJB1
uniprot id: F6SVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

13616:PPARD
gene id: 13616:PPARD
uniprot id: F6TVN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:CPEB1
gene id: 13616:CPEB1
uniprot id: F6RHI7
names: Similarity
messages: Belongs to the RRM CPEB family.

13616:SLC10A4
gene id: 13616:SLC10A4
uniprot id: F7EN54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:RPN1
gene id: 13616:RPN1
uniprot id: F6YJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:TCEANC2
gene id: 13616:TCEANC2
uniprot id: A0A5F8GXD5
names: Subcellular Location Annotation
messages: Nucleus

13616:SUPT6H
gene id: 13616:SUPT6H
uniprot id: F6RZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

13616:TMCO1
gene id: 13616:TMCO1
uniprot id: F7FWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

13616:ACAA2
gene id: 13616:ACAA2
uniprot id: F7FBH6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

13616:PLCB2
gene id: 13616:PLCB2
uniprot id: F6Y4X0
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

13616:PPIB
gene id: 13616:PPIB
uniprot id: F7BZB1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

13616:LOC100031497
gene id: 13616:LOC100031497
uniprot id: H9H7Z0
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LAMA3
gene id: 13616:LAMA3
uniprot id: A0A5F8H112
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

13616:LOC100018508
gene id: 13616:LOC100018508
uniprot id: A0A5F8HB60
uniprot id: F7GHL5
names: Similarity
messages: Belongs to the NLRP family.

13616:KIFBP
gene id: 13616:KIFBP
uniprot id: A0A5F8G6K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

13616:MRPL4
gene id: 13616:MRPL4
uniprot id: F7CG27
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

13616:NMNAT2
gene id: 13616:NMNAT2
uniprot id: A0A5F8GHY9
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

13616:LOC100032166
gene id: 13616:LOC100032166
uniprot id: A0A5F8H431
uniprot id: F6R8A4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:LOC100022521
gene id: 13616:LOC100022521
uniprot id: F6SPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:BORCS7
gene id: 13616:BORCS7
uniprot id: A0A5F8H3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

13616:SLC18A1
gene id: 13616:SLC18A1
uniprot id: F6WAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

13616:NIPSNAP3A
gene id: 13616:NIPSNAP3A
uniprot id: F7C1W8
names: Similarity
messages: Belongs to the NipSnap family.

13616:IL6
gene id: 13616:IL6
uniprot id: F7CIZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

13616:SPOP
gene id: 13616:SPOP
uniprot id: A0A5F8GQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

13616:KCNK10
gene id: 13616:KCNK10
uniprot id: A0A5F8GXD9
uniprot id: F7CTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:PSMB5
gene id: 13616:PSMB5
uniprot id: F7E8A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

13616:SLC6A12
gene id: 13616:SLC6A12
uniprot id: F6QVR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

13616:LOC100014573
gene id: 13616:LOC100014573
uniprot id: F7C5A4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

13616:GPM6B
gene id: 13616:GPM6B
uniprot id: A0A5F8G329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

13616:POU4F3
gene id: 13616:POU4F3
uniprot id: F6WMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

13616:POMK
gene id: 13616:POMK
uniprot id: A0A5F8GTZ9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

13616:SCUBE3
gene id: 13616:SCUBE3
uniprot id: A0A5F8GUZ2
uniprot id: A0A5F8H314
uniprot id: F6SEA3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:LOC103095510
gene id: 13616:LOC103095510
uniprot id: A0A5F8GUA5
names: Similarity
messages: Belongs to the MS4A family.

13616:CEP70
gene id: 13616:CEP70
uniprot id: F7FRD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

13616:monDomV1R1286
gene id: 13616:monDomV1R1286
uniprot id: A0A5F8H1H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100017912
gene id: 13616:LOC100017912
uniprot id: F6UHN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:TCP11
gene id: 13616:TCP11
uniprot id: F6X6Q9
names: Similarity
messages: Belongs to the TCP11 family.

13616:LOC100015106
gene id: 13616:LOC100015106
uniprot id: F6SRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MODO-UI
gene id: 13616:MODO-UI
uniprot id: C6ZIV2
names: Similarity
messages: Belongs to the MHC class I family.

13616:PSME2
gene id: 13616:PSME2
uniprot id: A0A5F8GJ15
names: Similarity
messages: Belongs to the PA28 family.

13616:COQ4
gene id: 13616:COQ4
uniprot id: F6WFU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

13616:BRIX1
gene id: 13616:BRIX1
uniprot id: F7C078
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

13616:ASF1B
gene id: 13616:ASF1B
uniprot id: F7G4J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

13616:RDH10
gene id: 13616:RDH10
uniprot id: F6SH88
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:DNASE1
gene id: 13616:DNASE1
uniprot id: F7E8P4
names: Similarity
messages: Belongs to the DNase I family.

13616:SNX3
gene id: 13616:SNX3
uniprot id: A0A5F8GWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

13616:LOC100023355
gene id: 13616:LOC100023355
uniprot id: A0A5F8HCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100020750
gene id: 13616:LOC100020750
uniprot id: F7EXX3
names: Similarity
messages: Belongs to the fructosamine kinase family.

13616:NFIB
gene id: 13616:NFIB
uniprot id: A0A5F8GI82
uniprot id: F6RH94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

13616:ZDHHC4
gene id: 13616:ZDHHC4
uniprot id: A0A5F8HJH6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:CCK
gene id: 13616:CCK
uniprot id: F7EMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

13616:GNG4
gene id: 13616:GNG4
uniprot id: K7E376
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:TBC1D7
gene id: 13616:TBC1D7
uniprot id: F7DPC6
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

13616:ARL5B
gene id: 13616:ARL5B
uniprot id: F7FZL7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

13616:RXRB
gene id: 13616:RXRB
uniprot id: A0A5F8H805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

13616:MRPL2
gene id: 13616:MRPL2
uniprot id: F7FNZ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

13616:TLCD1
gene id: 13616:TLCD1
uniprot id: F6RZ31
names: Subcellular Location Annotation
messages: Membrane

13616:CHRNE
gene id: 13616:CHRNE
uniprot id: A0A5F8HBH8
uniprot id: A0A5F8HCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:MAB21L2
gene id: 13616:MAB21L2
uniprot id: F6VDM5
names: Similarity
messages: Belongs to the mab-21 family.

13616:NOC3L
gene id: 13616:NOC3L
uniprot id: F6VL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

13616:TRDMT1
gene id: 13616:TRDMT1
uniprot id: F6WAN0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

13616:GPBP1L1
gene id: 13616:GPBP1L1
uniprot id: A0A5F8GP61
uniprot id: F7DFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

13616:GRHPR
gene id: 13616:GRHPR
uniprot id: A0A5F8GK27
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

13616:VN2R634
gene id: 13616:VN2R634
uniprot id: A0A5F8G5Y0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:RNF157
gene id: 13616:RNF157
uniprot id: A0A5F8GMR4
uniprot id: F7F2M0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

13616:MAT1A
gene id: 13616:MAT1A
uniprot id: F7F413
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

13616:GTF3C5
gene id: 13616:GTF3C5
uniprot id: A0A5F8H6L2
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC654275
gene id: 13616:LOC654275
uniprot id: Q2V578
names: Similarity
messages: Belongs to the peptidase C14A family.

13616:EIF3B
gene id: 13616:EIF3B
uniprot id: F6SZX9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: The RRM domain mediates interaction with EIF3J.

13616:PSMA3
gene id: 13616:PSMA3
uniprot id: F7ETB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

13616:DCHS2
gene id: 13616:DCHS2
uniprot id: F7GH79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:FHIP2B
gene id: 13616:FHIP2B
uniprot id: F6QTD9
uniprot id: F7DSY2
names: Similarity
messages: Belongs to the FHIP family.

13616:T2R3F
gene id: 13616:T2R3F
uniprot id: Q2ABA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:NDUFB5
gene id: 13616:NDUFB5
uniprot id: F7G3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

13616:DLX2
gene id: 13616:DLX2
uniprot id: F7B4F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

13616:MRPL18
gene id: 13616:MRPL18
uniprot id: F7EDX2
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

13616:LOC100018068
gene id: 13616:LOC100018068
uniprot id: F6QIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

13616:THTPA
gene id: 13616:THTPA
uniprot id: A0A5F8GA32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

13616:TMEM9B
gene id: 13616:TMEM9B
uniprot id: F7GAU1
names: Similarity
messages: Belongs to the TMEM9 family.

13616:ADAM10
gene id: 13616:ADAM10
uniprot id: F6PTE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PELI2
gene id: 13616:PELI2
uniprot id: F7FZH7
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

13616:LOC103103098
gene id: 13616:LOC103103098
uniprot id: K7E3D5
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

13616:MOGAT2
gene id: 13616:MOGAT2
uniprot id: F7BUD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:STARD13
gene id: 13616:STARD13
uniprot id: F6YBE5
names: Subcellular Location Annotation
messages: Cytoplasm

13616:EMP2
gene id: 13616:EMP2
uniprot id: A0A5F8G6A2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

13616:GMPPA
gene id: 13616:GMPPA
uniprot id: F7F3V5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

13616:MMP13
gene id: 13616:MMP13
uniprot id: F6SS23
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:LOC100029406
gene id: 13616:LOC100029406
uniprot id: F7EYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FAM120B
gene id: 13616:FAM120B
uniprot id: A0A5F8G7V9
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

13616:LOC100028903
gene id: 13616:LOC100028903
uniprot id: F6T1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

13616:KDR
gene id: 13616:KDR
uniprot id: F7DLA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:DES
gene id: 13616:DES
uniprot id: F7BWE5
names: Similarity
messages: Belongs to the intermediate filament family.

13616:NNMT
gene id: 13616:NNMT
uniprot id: F6SV98
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

13616:monDomV1R1264
gene id: 13616:monDomV1R1264
uniprot id: A0A5F8GFQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:FMNL2
gene id: 13616:FMNL2
uniprot id: A0A5F8GTE0
uniprot id: F6UDT7
names: Similarity
messages: Belongs to the formin homology family.

13616:LOC100027959
gene id: 13616:LOC100027959
uniprot id: A0A5F8H8Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CFDP1
gene id: 13616:CFDP1
uniprot id: A0A5F8HGI5
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

13616:RECQL4
gene id: 13616:RECQL4
uniprot id: F7FVC5
names: Subcellular Location Annotation
messages: Nucleus

13616:ZACN
gene id: 13616:ZACN
uniprot id: F6ZYC6
names: Subcellular Location Annotation
messages: Membrane

13616:PLG
gene id: 13616:PLG
uniprot id: F7F243
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

13616:VPS26B
gene id: 13616:VPS26B
uniprot id: F7FVE6
names: Similarity
messages: Belongs to the VPS26 family.

13616:RPL17
gene id: 13616:RPL17
uniprot id: F7GBR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

13616:LUC7L3
gene id: 13616:LUC7L3
uniprot id: A0A5F8GH27
names: Similarity
messages: Belongs to the Luc7 family.

13616:MRPS21
gene id: 13616:MRPS21
uniprot id: F7AD79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

13616:TAS2R4
gene id: 13616:TAS2R4
uniprot id: Q2ABA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

13616:LOC100021126
gene id: 13616:LOC100021126
uniprot id: F6RN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL27
gene id: 13616:RPL27
uniprot id: A0A5F8H0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

13616:UBE2C
gene id: 13616:UBE2C
uniprot id: F6TXY0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:CC2D1A
gene id: 13616:CC2D1A
uniprot id: F7CV27
names: Similarity
messages: Belongs to the CC2D1 family.

13616:NR2F6
gene id: 13616:NR2F6
uniprot id: F7FUW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

13616:PRIMPOL
gene id: 13616:PRIMPOL
uniprot id: F6UQC2
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

13616:LOC130453508
gene id: 13616:LOC130453508
uniprot id: F7AL73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TMEM170A
gene id: 13616:TMEM170A
uniprot id: A0A5F8G3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

13616:LOC100013658
gene id: 13616:LOC100013658
uniprot id: F7C2G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PREPL
gene id: 13616:PREPL
uniprot id: A0A5F8HHU7
names: Similarity
messages: Belongs to the peptidase S9A family.

13616:ZFHX4
gene id: 13616:ZFHX4
uniprot id: F7BTH3
names: Subcellular Location Annotation
messages: Nucleus

13616:ACTR1B
gene id: 13616:ACTR1B
uniprot id: F7GIQ3
names: Similarity
messages: Belongs to the actin family.

13616:LOC100020741
gene id: 13616:LOC100020741
uniprot id: A0A5F8GCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNX18
gene id: 13616:SNX18
uniprot id: A0A5F8HGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

13616:TK1
gene id: 13616:TK1
uniprot id: F6SP09
names: Similarity
messages: Belongs to the thymidine kinase family.

13616:TOMM22
gene id: 13616:TOMM22
uniprot id: F6QTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

13616:C5AR2
gene id: 13616:C5AR2
uniprot id: F6VWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

13616:T2R29
gene id: 13616:T2R29
uniprot id: Q2AB90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:BICD1
gene id: 13616:BICD1
uniprot id: A0A5F8GLC8
uniprot id: F6TI85
names: Similarity
messages: Belongs to the BicD family.

13616:ADI1
gene id: 13616:ADI1
uniprot id: F7FKV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

13616:PRPF31
gene id: 13616:PRPF31
uniprot id: K7E106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

13616:TFAP2C
gene id: 13616:TFAP2C
uniprot id: A0A5F8GI09
uniprot id: F7A4W2
names: Similarity
messages: Belongs to the AP-2 family.

13616:NETO2
gene id: 13616:NETO2
uniprot id: F7C941
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PPAT
gene id: 13616:PPAT
uniprot id: K7DZI9
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

13616:SPOUT1
gene id: 13616:SPOUT1
uniprot id: K7E3J4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

13616:SEC61G
gene id: 13616:SEC61G
uniprot id: A0A5F8GZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:HECTD1
gene id: 13616:HECTD1
uniprot id: F7B4N3
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

13616:KIF4A
gene id: 13616:KIF4A
uniprot id: A0A5F8HH41
uniprot id: F6TNW7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:RAP2B
gene id: 13616:RAP2B
uniprot id: F7DGX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

13616:ANKRD13B
gene id: 13616:ANKRD13B
uniprot id: F6REP0
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

13616:CEBPD
gene id: 13616:CEBPD
uniprot id: F7DQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:BAMBI
gene id: 13616:BAMBI
uniprot id: F7CL00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

13616:KCNK5
gene id: 13616:KCNK5
uniprot id: F6ZM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

13616:LOC100022691
gene id: 13616:LOC100022691
uniprot id: F6RKE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100015376
gene id: 13616:LOC100015376
uniprot id: F7CK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

13616:FOXO3
gene id: 13616:FOXO3
uniprot id: F7B7W4
names: Subcellular Location Annotation
messages: Nucleus

13616:KCNJ5
gene id: 13616:KCNJ5
uniprot id: F6WK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

13616:S100A11
gene id: 13616:S100A11
uniprot id: A0A5F8GTE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

13616:PIK3R1
gene id: 13616:PIK3R1
uniprot id: A0A5F8GUR3
uniprot id: A0A5F8HK88
uniprot id: F6TD14
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

13616:ACADL
gene id: 13616:ACADL
uniprot id: F7FE37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

13616:APOE
gene id: 13616:APOE
uniprot id: A0A5F8HC70
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

13616:CLDN14
gene id: 13616:CLDN14
uniprot id: F6Z9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:DDX49
gene id: 13616:DDX49
uniprot id: F7ECS2
names: Similarity
messages: Belongs to the DEAD box helicase family.

13616:LOC100014048
gene id: 13616:LOC100014048
uniprot id: F6W3D7
names: Similarity
messages: Belongs to the histone H3 family.

13616:SLC26A2
gene id: 13616:SLC26A2
uniprot id: A0A5F8HCP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

13616:QARS1
gene id: 13616:QARS1
uniprot id: F7GJG2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

13616:RPL13A
gene id: 13616:RPL13A
uniprot id: F6TPW7
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

13616:CDH9
gene id: 13616:CDH9
uniprot id: F6UBJ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:LOC100014611
gene id: 13616:LOC100014611
uniprot id: F7G7A3
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

13616:ACVR2B
gene id: 13616:ACVR2B
uniprot id: A0A5F8GCP7
uniprot id: F7BRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

13616:LOC100010036
gene id: 13616:LOC100010036
uniprot id: F6Q228
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SKA1
gene id: 13616:SKA1
uniprot id: F6ZJ97
names: Similarity
messages: Belongs to the SKA1 family.

13616:SAP30
gene id: 13616:SAP30
uniprot id: F7GBR9
names: Similarity
messages: Belongs to the SAP30 family.

13616:ATP5MK
gene id: 13616:ATP5MK
uniprot id: F6T294
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

13616:LACTB2
gene id: 13616:LACTB2
uniprot id: F7FC68
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

13616:STX3
gene id: 13616:STX3
uniprot id: A0A5F8GG36
names: Similarity
messages: Belongs to the syntaxin family.

13616:SLC5A7
gene id: 13616:SLC5A7
uniprot id: F7DI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:CIMIP2C
gene id: 13616:CIMIP2C
uniprot id: F6Z4I5
names: Similarity
messages: Belongs to the CIMIP2 family.

13616:VAMP3
gene id: 13616:VAMP3
uniprot id: F7G4F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:SNRPD3
gene id: 13616:SNRPD3
uniprot id: A0A5F8HCX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

13616:SNRNP200
gene id: 13616:SNRNP200
uniprot id: F7G4E6
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

13616:RPN2
gene id: 13616:RPN2
uniprot id: A0A5F8H1J6
uniprot id: A0A5F8H4T9
uniprot id: F6VUZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

13616:UCP1
gene id: 13616:UCP1
uniprot id: F6X9Y8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

13616:SUPT16H
gene id: 13616:SUPT16H
uniprot id: F7BV95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

13616:CTNNB1
gene id: 13616:CTNNB1
uniprot id: F6SRK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

13616:DLAT
gene id: 13616:DLAT
uniprot id: A0A5F8G712
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

13616:AGPS
gene id: 13616:AGPS
uniprot id: F6YBI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

13616:UBIAD1
gene id: 13616:UBIAD1
uniprot id: F7E5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

13616:WFIKKN2
gene id: 13616:WFIKKN2
uniprot id: F6VGY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

13616:HADH
gene id: 13616:HADH
uniprot id: F6ZBI7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

13616:ILVBL
gene id: 13616:ILVBL
uniprot id: F7ERP5
names: Similarity
messages: Belongs to the TPP enzyme family.

13616:INO80
gene id: 13616:INO80
uniprot id: F6TFW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

13616:INKA2
gene id: 13616:INKA2
uniprot id: A0A5F8G6J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

13616:ATPAF1
gene id: 13616:ATPAF1
uniprot id: F6W119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

13616:monDomV1R1224
gene id: 13616:monDomV1R1224
uniprot id: F7E1L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DCK
gene id: 13616:DCK
uniprot id: F7FN05
names: Similarity
messages: Belongs to the DCK/DGK family.

13616:MRPS12
gene id: 13616:MRPS12
uniprot id: A0A5F8GIA4
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

13616:SPPL3
gene id: 13616:SPPL3
uniprot id: A0A5F8GQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

13616:monDomV1R1290
gene id: 13616:monDomV1R1290
uniprot id: H9H885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PPP1R13B
gene id: 13616:PPP1R13B
uniprot id: A0A5F8GRE7
uniprot id: A0A5F8HD73
uniprot id: F7C3K5
names: Subcellular Location Annotation
messages: Nucleus

13616:HIBCH
gene id: 13616:HIBCH
uniprot id: F6QBJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

13616:RPL23
gene id: 13616:RPL23
uniprot id: F6WU43
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

13616:CCR6
gene id: 13616:CCR6
uniprot id: A0A5F8GLZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MRPS36
gene id: 13616:MRPS36
uniprot id: F6TC86
names: Subcellular Location Annotation
messages: Mitochondrion

13616:MDH1
gene id: 13616:MDH1
uniprot id: F6PLH7
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

13616:CCT4
gene id: 13616:CCT4
uniprot id: F7B657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:SURF6
gene id: 13616:SURF6
uniprot id: F6T186
names: Similarity
messages: Belongs to the SURF6 family.

13616:GNB1
gene id: 13616:GNB1
uniprot id: F6PVT7
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

13616:MYT1
gene id: 13616:MYT1
uniprot id: A0A5F8HC68
uniprot id: A0A5F8HCF7
uniprot id: F6VKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

13616:MIS18A
gene id: 13616:MIS18A
uniprot id: A0A5F8G4M6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

13616:GNPNAT1
gene id: 13616:GNPNAT1
uniprot id: A0A5F8HFP4
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

13616:RAPSN
gene id: 13616:RAPSN
uniprot id: A0A5F8GTM3
names: Similarity
messages: Belongs to the RAPsyn family.

13616:LOC100030425
gene id: 13616:LOC100030425
uniprot id: F7B4E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SNX9
gene id: 13616:SNX9
uniprot id: A0A5F8HCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

13616:FOXR1
gene id: 13616:FOXR1
uniprot id: F7GA66
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100028573
gene id: 13616:LOC100028573
uniprot id: F6V606
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PTHLH
gene id: 13616:PTHLH
uniprot id: A0A5F8GKI1
uniprot id: F7BH65
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

13616:ATG7
gene id: 13616:ATG7
uniprot id: A0A5F8GWF5
uniprot id: F7BSZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

13616:CACNG3
gene id: 13616:CACNG3
uniprot id: F7A5K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

13616:SLC10A6
gene id: 13616:SLC10A6
uniprot id: F6ZZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:LOC100019123
gene id: 13616:LOC100019123
uniprot id: F7BUJ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

13616:MMP9
gene id: 13616:MMP9
uniprot id: F6X875
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

13616:FIS1
gene id: 13616:FIS1
uniprot id: F7E999
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

13616:ERCC3
gene id: 13616:ERCC3
uniprot id: F7FQP6
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

13616:IL17D
gene id: 13616:IL17D
uniprot id: F7DJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

13616:CLCN4
gene id: 13616:CLCN4
uniprot id: F6ZVD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

13616:ETS1
gene id: 13616:ETS1
uniprot id: A0A5F8H0C9
uniprot id: F6Y1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

13616:TSSK2
gene id: 13616:TSSK2
uniprot id: F6Y592
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:LMX1A
gene id: 13616:LMX1A
uniprot id: F7CIX3
names: Subcellular Location Annotation
messages: Nucleus

13616:METTL2A
gene id: 13616:METTL2A
uniprot id: F6W5L3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

13616:MIGA2
gene id: 13616:MIGA2
uniprot id: A0A5F8GU90
names: Similarity
messages: Belongs to the mitoguardin family.

13616:GNPAT
gene id: 13616:GNPAT
uniprot id: A0A5F8GDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

13616:TEK
gene id: 13616:TEK
uniprot id: F6TEV1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:PCLAF
gene id: 13616:PCLAF
uniprot id: A0A5F8H0S8
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

13616:DSE
gene id: 13616:DSE
uniprot id: F6Z8C6
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

13616:PGAM1
gene id: 13616:PGAM1
uniprot id: F6UBE9
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

13616:HUS1
gene id: 13616:HUS1
uniprot id: F7AYQ2
names: Similarity
messages: Belongs to the HUS1 family.

13616:STX2
gene id: 13616:STX2
uniprot id: A0A5F8GGV0
uniprot id: F6ZTR8
names: Similarity
messages: Belongs to the syntaxin family.

13616:POLR2C
gene id: 13616:POLR2C
uniprot id: F7CLY1
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

13616:SLC25A24
gene id: 13616:SLC25A24
uniprot id: F6YHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:BPGM
gene id: 13616:BPGM
uniprot id: F6XLJ9
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

13616:LOC100020624
gene id: 13616:LOC100020624
uniprot id: F7API2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC35B1
gene id: 13616:SLC35B1
uniprot id: A0A5F8GQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

13616:ITGA1
gene id: 13616:ITGA1
uniprot id: F6RXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

13616:NUDT3
gene id: 13616:NUDT3
uniprot id: A0A5F8GS10
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

13616:EIF4A1
gene id: 13616:EIF4A1
uniprot id: F6UEF7
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

13616:FAM163A
gene id: 13616:FAM163A
uniprot id: F7AI30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

13616:LOC100024870
gene id: 13616:LOC100024870
uniprot id: F6VY06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100010620
gene id: 13616:LOC100010620
uniprot id: A0A5F8HEK2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

13616:HSD17B2
gene id: 13616:HSD17B2
uniprot id: F7CF43
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:UCHL3
gene id: 13616:UCHL3
uniprot id: A0A5F8GPB4
uniprot id: A0A5F8HB82
names: Similarity
messages: Belongs to the peptidase C12 family.

13616:KIF5C
gene id: 13616:KIF5C
uniprot id: F7GBT8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:GADD45A
gene id: 13616:GADD45A
uniprot id: F6SSE6
names: Similarity
messages: Belongs to the GADD45 family.

13616:C6H11orf58
gene id: 13616:C6H11orf58
uniprot id: A0A5F8GUU7
names: Similarity
messages: Belongs to the SMAP family.

13616:TTYH2
gene id: 13616:TTYH2
uniprot id: F7DGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

13616:CMBL
gene id: 13616:CMBL
uniprot id: F7GD97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

13616:LOC100012925
gene id: 13616:LOC100012925
uniprot id: F6TUB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

13616:RAD23B
gene id: 13616:RAD23B
uniprot id: F7ASD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

13616:LOC103094872
gene id: 13616:LOC103094872
uniprot id: F7A4Z1
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

13616:FLAD1
gene id: 13616:FLAD1
uniprot id: F6U398
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

13616:STX4
gene id: 13616:STX4
uniprot id: F6WIC9
names: Similarity
messages: Belongs to the syntaxin family.

13616:EXOSC9
gene id: 13616:EXOSC9
uniprot id: F7GJQ1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:SRRD
gene id: 13616:SRRD
uniprot id: A0A5F8GPP7
names: Similarity
messages: Belongs to the SRR1 family.

13616:HOXD12
gene id: 13616:HOXD12
uniprot id: F6ZN53
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC103093231
gene id: 13616:LOC103093231
uniprot id: A0A5F8H499
uniprot id: F7EY06
names: Similarity
messages: Belongs to the DeSI family.

13616:NUBPL
gene id: 13616:NUBPL
uniprot id: F6Y1Q6
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

13616:CHL1
gene id: 13616:CHL1
uniprot id: A0A5F8GJJ1
uniprot id: A0A5F8GW74
uniprot id: F7FUN9
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

13616:LOC100022574
gene id: 13616:LOC100022574
uniprot id: A0A5F8HKT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:NIPAL4
gene id: 13616:NIPAL4
uniprot id: F7BV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

13616:GDPD1
gene id: 13616:GDPD1
uniprot id: A0A5F8HB23
uniprot id: F7A3Y6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:LOC100016646
gene id: 13616:LOC100016646
uniprot id: F6ZJ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:FGFBP1
gene id: 13616:FGFBP1
uniprot id: F7DVS2
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

13616:VPS37A
gene id: 13616:VPS37A
uniprot id: F7AXY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

13616:LOC100013399
gene id: 13616:LOC100013399
uniprot id: F7E7L5
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:VASN
gene id: 13616:VASN
uniprot id: A0A5F8GZI3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:ABCC2
gene id: 13616:ABCC2
uniprot id: F6Z127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

13616:LOC100022970
gene id: 13616:LOC100022970
uniprot id: F7FNQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:MARCKSL1
gene id: 13616:MARCKSL1
uniprot id: A0A5F8H539
names: Similarity
messages: Belongs to the MARCKS family.

13616:DDX24
gene id: 13616:DDX24
uniprot id: F7BYY3
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

13616:MED13L
gene id: 13616:MED13L
uniprot id: F6WRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

13616:LOC100031129
gene id: 13616:LOC100031129
uniprot id: A0A5F8H461
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:TM7SF2
gene id: 13616:TM7SF2
uniprot id: F6X4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

13616:CEPT1
gene id: 13616:CEPT1
uniprot id: A0A5F8GM01
uniprot id: A0A5F8GVL7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

13616:SLC25A12
gene id: 13616:SLC25A12
uniprot id: A0A5F8GID9
uniprot id: A0A5F8HDF6
uniprot id: F7CUN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:DPY30
gene id: 13616:DPY30
uniprot id: A0A5F8GVZ3
names: Similarity
messages: Belongs to the dpy-30 family.

13616:LOC100026326
gene id: 13616:LOC100026326
uniprot id: F6SDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

13616:HCAR2
gene id: 13616:HCAR2
uniprot id: F7EJ94
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:CNDP2
gene id: 13616:CNDP2
uniprot id: F7DHK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

13616:CEP76
gene id: 13616:CEP76
uniprot id: K7E5R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

13616:CETP
gene id: 13616:CETP
uniprot id: F7FMG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Secreted

13616:LOC100020571
gene id: 13616:LOC100020571
uniprot id: K7E4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:RTRAF
gene id: 13616:RTRAF
uniprot id: F7EW01
names: Similarity
messages: Belongs to the RTRAF family.

13616:NFE2L1
gene id: 13616:NFE2L1
uniprot id: F7DHJ0
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

13616:TRIM42
gene id: 13616:TRIM42
uniprot id: F7BPR2
names: Subcellular Location Annotation
messages: Cytoplasm

13616:MMAA
gene id: 13616:MMAA
uniprot id: F6Y622
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

13616:monDomV1R1285
gene id: 13616:monDomV1R1285
uniprot id: A0A5F8GKY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1283
gene id: 13616:monDomV1R1283
uniprot id: F7GES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TTC9B
gene id: 13616:TTC9B
uniprot id: F7CPA1
names: Similarity
messages: Belongs to the TTC9 family.

13616:DSTN
gene id: 13616:DSTN
uniprot id: F7D0S2
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

13616:monDomV1R1241
gene id: 13616:monDomV1R1241
uniprot id: A0A5F8GDD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PHACTR1
gene id: 13616:PHACTR1
uniprot id: A0A5F8G831
uniprot id: A0A5F8GXK5
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

13616:FITM2
gene id: 13616:FITM2
uniprot id: F7FM06
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:FAM91A1
gene id: 13616:FAM91A1
uniprot id: F6W104
names: Similarity
messages: Belongs to the FAM91 family.

13616:KCNA10
gene id: 13616:KCNA10
uniprot id: F6UCT6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC103092739
gene id: 13616:LOC103092739
uniprot id: A0A5F8GWY8
names: Similarity
messages: Belongs to the SELO family.

13616:TLR8
gene id: 13616:TLR8
uniprot id: A0A5F8HJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

13616:FZR1
gene id: 13616:FZR1
uniprot id: F6PS44
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

13616:GSX1
gene id: 13616:GSX1
uniprot id: F7BPX3
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100022548
gene id: 13616:LOC100022548
uniprot id: F6SPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ADRB1
gene id: 13616:ADRB1
uniprot id: F6WB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LGR5
gene id: 13616:LGR5
uniprot id: A0A5F8H0S9
uniprot id: F7BZE9
names: Subcellular Location Annotation
messages: Membrane

13616:ADIPOR2
gene id: 13616:ADIPOR2
uniprot id: F6XUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:CD109
gene id: 13616:CD109
uniprot id: F7AG87
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

13616:LOC100009907
gene id: 13616:LOC100009907
uniprot id: F7F9V8
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

13616:TRMT6
gene id: 13616:TRMT6
uniprot id: F7AA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

13616:CFAP126
gene id: 13616:CFAP126
uniprot id: A0A5F8GAU4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

13616:YBEY
gene id: 13616:YBEY
uniprot id: F7GEX4
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

13616:A1CF
gene id: 13616:A1CF
uniprot id: F6ZDI9
names: Subcellular Location Annotation
messages: Cytoplasm

13616:ILDR1
gene id: 13616:ILDR1
uniprot id: F6PWR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

13616:SLC10A2
gene id: 13616:SLC10A2
uniprot id: F6XEC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

13616:LOC100012302
gene id: 13616:LOC100012302
uniprot id: F6VZJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:ACSF3
gene id: 13616:ACSF3
uniprot id: F7DU27
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:CLGN
gene id: 13616:CLGN
uniprot id: F6XSA8
names: Similarity
messages: Belongs to the calreticulin family.

13616:LOC100021845
gene id: 13616:LOC100021845
uniprot id: F7BRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CLCC1
gene id: 13616:CLCC1
uniprot id: F7DG03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

13616:KIT
gene id: 13616:KIT
uniprot id: F7A906
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:HOXD3
gene id: 13616:HOXD3
uniprot id: A0A5F8GV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:SYNJ2
gene id: 13616:SYNJ2
uniprot id: A0A5F8GIJ1
uniprot id: A0A5F8H903
uniprot id: F7AW70
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

13616:GATA1
gene id: 13616:GATA1
uniprot id: F6X583
names: Subcellular Location Annotation
messages: Nucleus

13616:OPA3
gene id: 13616:OPA3
uniprot id: F7DZP8
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

13616:PDGFB
gene id: 13616:PDGFB
uniprot id: F7BJK8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

13616:MODO-UC
gene id: 13616:MODO-UC
uniprot id: Q5W5U5
names: Similarity
messages: Belongs to the MHC class I family.

13616:GDPD4
gene id: 13616:GDPD4
uniprot id: A0A5F8GH73
uniprot id: F6YMM7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

13616:KLC1
gene id: 13616:KLC1
uniprot id: A0A5F8G7Y9
uniprot id: A0A5F8GHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

13616:HMMR
gene id: 13616:HMMR
uniprot id: A0A5F8HEW4
names: Subcellular Location Annotation
messages: spindle

13616:LOC100010708
gene id: 13616:LOC100010708
uniprot id: A0A5F8HBE4
names: Subcellular Location Annotation
messages: Membrane

13616:CCDC124
gene id: 13616:CCDC124
uniprot id: A0A5F8HBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

13616:LOC100025505
gene id: 13616:LOC100025505
uniprot id: F6X6X2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

13616:PCBD2
gene id: 13616:PCBD2
uniprot id: A0A5F8GNM8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

13616:LOC100027418
gene id: 13616:LOC100027418
uniprot id: K7DYR4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

13616:NEU4
gene id: 13616:NEU4
uniprot id: A0A5F8HF43
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

13616:TXNDC8
gene id: 13616:TXNDC8
uniprot id: F6QYH1
names: Similarity
messages: Belongs to the thioredoxin family.

13616:POU3F4
gene id: 13616:POU3F4
uniprot id: F6X0R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

13616:NOVA1
gene id: 13616:NOVA1
uniprot id: A0A5F8HCR7
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

13616:LOC100020945
gene id: 13616:LOC100020945
uniprot id: F6TES4
names: Similarity
messages: Belongs to the SNF7 family.

13616:HSD17B4
gene id: 13616:HSD17B4
uniprot id: F7CLZ9
names: Subcellular Location Annotation
messages: Peroxisome

13616:TBX15
gene id: 13616:TBX15
uniprot id: F7D2N6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:LOC100619430
gene id: 13616:LOC100619430
uniprot id: F7FAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

13616:PARP10
gene id: 13616:PARP10
uniprot id: F7A7Q9
names: Similarity
messages: Belongs to the ARTD/PARP family.

13616:PROX1
gene id: 13616:PROX1
uniprot id: A0A5F8GR59
uniprot id: F6TZI0
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100011399
gene id: 13616:LOC100011399
uniprot id: F7DNQ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:DGCR6L
gene id: 13616:DGCR6L
uniprot id: K7E0E6
names: Similarity
messages: Belongs to the gonadal family.

13616:DHRS9
gene id: 13616:DHRS9
uniprot id: F6YT90
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

13616:FLT1
gene id: 13616:FLT1
uniprot id: F7EY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1266
gene id: 13616:monDomV1R1266
uniprot id: A0A5F8GNL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PRPF38A
gene id: 13616:PRPF38A
uniprot id: F6SUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

13616:FBXL5
gene id: 13616:FBXL5
uniprot id: F6YQZ8
names: Subcellular Location Annotation
messages: perinuclear region

13616:CRAT
gene id: 13616:CRAT
uniprot id: A0A5F8H5F9
uniprot id: F7DGV8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:TCF25
gene id: 13616:TCF25
uniprot id: A0A5F8H2L2
names: Similarity
messages: Belongs to the TCF25 family.

13616:GADD45G
gene id: 13616:GADD45G
uniprot id: F7G7J2
names: Similarity
messages: Belongs to the GADD45 family.

13616:SLC25A20
gene id: 13616:SLC25A20
uniprot id: A0A5F8GDJ7
uniprot id: F7DSV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LOC100023529
gene id: 13616:LOC100023529
uniprot id: F7F434
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:LOC100031958
gene id: 13616:LOC100031958
uniprot id: F6YEH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

13616:LOC100023867
gene id: 13616:LOC100023867
uniprot id: F7AFL4
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:CFH
gene id: 13616:CFH
uniprot id: F7GF51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100028995
gene id: 13616:LOC100028995
uniprot id: F7BQ48
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:WASHC1
gene id: 13616:WASHC1
uniprot id: F6QVX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

13616:TMEM30B
gene id: 13616:TMEM30B
uniprot id: F6ZFS9
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

13616:MRPS7
gene id: 13616:MRPS7
uniprot id: F7FCF7
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

13616:TRPM6
gene id: 13616:TRPM6
uniprot id: F6QWI3
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

13616:MARK3
gene id: 13616:MARK3
uniprot id: A0A5F8G689
uniprot id: A0A5F8GGQ5
uniprot id: A0A5F8HIE6
uniprot id: A0A5F8HJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

13616:RNF8
gene id: 13616:RNF8
uniprot id: A0A5F8GGK1
uniprot id: A0A5F8GW89
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

13616:ADAMTS3
gene id: 13616:ADAMTS3
uniprot id: F7EC85
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:IRAK1BP1
gene id: 13616:IRAK1BP1
uniprot id: F6XBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

13616:AIF1L
gene id: 13616:AIF1L
uniprot id: A0A5F8HC25
names: Subcellular Location Annotation
messages: ruffle membrane

13616:PROM2
gene id: 13616:PROM2
uniprot id: F7D5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

13616:ERMP1
gene id: 13616:ERMP1
uniprot id: F6XXG5
names: Subcellular Location Annotation
messages: Membrane

13616:SLC26A5
gene id: 13616:SLC26A5
uniprot id: A0A5F8GG90
uniprot id: F6TKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ. Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane. The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC. The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization. The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding. Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and…

13616:LOC100030289
gene id: 13616:LOC100030289
uniprot id: F7CGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KCNJ3
gene id: 13616:KCNJ3
uniprot id: F6YV60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

13616:TMSB4X
gene id: 13616:TMSB4X
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:CHRNA2
gene id: 13616:CHRNA2
uniprot id: F6Z357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

13616:PALMD
gene id: 13616:PALMD
uniprot id: A0A5F8GCZ2
uniprot id: F7DTP3
names: Similarity
messages: Belongs to the paralemmin family.

13616:ATP5MC3
gene id: 13616:ATP5MC3
uniprot id: F7EV18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

13616:IPMK
gene id: 13616:IPMK
uniprot id: F7DS89
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:LOC100021631
gene id: 13616:LOC100021631
uniprot id: F6VES9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

13616:EML5
gene id: 13616:EML5
uniprot id: F6WDF5
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

13616:EGFL7
gene id: 13616:EGFL7
uniprot id: F7AHX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:MAS1
gene id: 13616:MAS1
uniprot id: F6ZNI5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:LOC100025543
gene id: 13616:LOC100025543
uniprot id: F7CGC3
names: Subcellular Location Annotation
messages: Secreted

13616:LOC100017183
gene id: 13616:LOC100017183
uniprot id: F7A3G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

13616:LYRM4
gene id: 13616:LYRM4
uniprot id: A0A5F8H234
uniprot id: A0A5F8H7Y2
names: Similarity
messages: Belongs to the complex I LYR family.

13616:PAQR4
gene id: 13616:PAQR4
uniprot id: A0A5F8H792
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:CTNNBL1
gene id: 13616:CTNNBL1
uniprot id: F6SZ07
names: Subcellular Location Annotation
messages: Nucleus

13616:LOC100019646
gene id: 13616:LOC100019646
uniprot id: F7E936
names: Subcellular Location Annotation
messages: Membrane

13616:DECR2
gene id: 13616:DECR2
uniprot id: F7E6L0
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

13616:NNT
gene id: 13616:NNT
uniprot id: F7C0X4
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

13616:CASR
gene id: 13616:CASR
uniprot id: F6PW91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100020127
gene id: 13616:LOC100020127
uniprot id: F7AZ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

13616:LGR6
gene id: 13616:LGR6
uniprot id: A0A5F8G6J6
uniprot id: A0A5F8HJT6
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100618293
gene id: 13616:LOC100618293
uniprot id: F7BAF0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

13616:LOC100028244
gene id: 13616:LOC100028244
uniprot id: F6WRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

13616:CMTM8
gene id: 13616:CMTM8
uniprot id: F7BW18
names: Subcellular Location Annotation
messages: Membrane

13616:GLP1R
gene id: 13616:GLP1R
uniprot id: F6ZL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

13616:TFF2
gene id: 13616:TFF2
uniprot id: F6QZC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CD5L
gene id: 13616:CD5L
uniprot id: F7C178
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:CLK1
gene id: 13616:CLK1
uniprot id: F7BXF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:FOXN2
gene id: 13616:FOXN2
uniprot id: F7GHF9
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC35B4
gene id: 13616:SLC35B4
uniprot id: F6X316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

13616:METTL15
gene id: 13616:METTL15
uniprot id: F7FNK2
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

13616:LOC100020170
gene id: 13616:LOC100020170
uniprot id: A0A5F8H0Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100617710
gene id: 13616:LOC100617710
uniprot id: F6SRP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:RPL9
gene id: 13616:RPL9
uniprot id: F7AQ39
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

13616:LOXL1
gene id: 13616:LOXL1
uniprot id: F6RXA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

13616:FAM53A
gene id: 13616:FAM53A
uniprot id: F6X726
names: Similarity
messages: Belongs to the FAM53 family.

13616:PNN
gene id: 13616:PNN
uniprot id: F7DZE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

13616:WDR4
gene id: 13616:WDR4
uniprot id: F6QYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

13616:LOC100013123
gene id: 13616:LOC100013123
uniprot id: A0A5F8G8L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MRPL32
gene id: 13616:MRPL32
uniprot id: H9H605
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

13616:SLC1A4
gene id: 13616:SLC1A4
uniprot id: F7DYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:SPIN1
gene id: 13616:SPIN1
uniprot id: F7D899
names: Similarity
messages: Belongs to the SPIN/STSY family.

13616:ATP8A2
gene id: 13616:ATP8A2
uniprot id: A0A5F8GX28
uniprot id: F6PFT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

13616:ADNP
gene id: 13616:ADNP
uniprot id: A0A5F8GCK9
names: Subcellular Location Annotation
messages: Nucleus

13616:TBPL2
gene id: 13616:TBPL2
uniprot id: F7GB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

13616:WNT2B
gene id: 13616:WNT2B
uniprot id: F7GH85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

13616:LOC100014688
gene id: 13616:LOC100014688
uniprot id: F7CUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TTC38
gene id: 13616:TTC38
uniprot id: F6YZQ3
names: Similarity
messages: Belongs to the TTC38 family.

13616:NEU3
gene id: 13616:NEU3
uniprot id: A0A5F8H7G2
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

13616:ISM1
gene id: 13616:ISM1
uniprot id: F7ERG0
names: Similarity
messages: Belongs to the isthmin family.

13616:ITPKC
gene id: 13616:ITPKC
uniprot id: A0A5F8H6M1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

13616:RENBP
gene id: 13616:RENBP
uniprot id: F6QCF6
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

13616:SCAP
gene id: 13616:SCAP
uniprot id: F6X2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

13616:SUMF2
gene id: 13616:SUMF2
uniprot id: F7EQ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

13616:ROCK2
gene id: 13616:ROCK2
uniprot id: A0A5F8HJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Membrane

13616:LOC100014544
gene id: 13616:LOC100014544
uniprot id: F6WAD9
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

13616:LOC100012635
gene id: 13616:LOC100012635
uniprot id: F6WA61
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

13616:P4HB
gene id: 13616:P4HB
uniprot id: F6Q3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

13616:TOR4A
gene id: 13616:TOR4A
uniprot id: F6WXT3
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

13616:DSC1
gene id: 13616:DSC1
uniprot id: A0A5F8GL62
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

13616:PROZ
gene id: 13616:PROZ
uniprot id: A0A5F8GN67
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LYSET
gene id: 13616:LYSET
uniprot id: F7G3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

13616:UBE2F
gene id: 13616:UBE2F
uniprot id: F7CUS8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:TMEM50B
gene id: 13616:TMEM50B
uniprot id: F6V201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

13616:LOC100019177
gene id: 13616:LOC100019177
uniprot id: F7AJJ0
names: Similarity
messages: Belongs to the S-100 family.

13616:LOC100617751
gene id: 13616:LOC100617751
uniprot id: F7ENP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

13616:VN2R614
gene id: 13616:VN2R614
uniprot id: A0A5F8H8T7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:NDUFB7
gene id: 13616:NDUFB7
uniprot id: F7G4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

13616:ADRM1
gene id: 13616:ADRM1
uniprot id: A0A5F8GYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

13616:STARD3NL
gene id: 13616:STARD3NL
uniprot id: A0A5F8GHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

13616:ZDHHC1
gene id: 13616:ZDHHC1
uniprot id: F6WW01
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:ORC6
gene id: 13616:ORC6
uniprot id: F7EFU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

13616:CPQ
gene id: 13616:CPQ
uniprot id: F6PX15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome

13616:CFAP206
gene id: 13616:CFAP206
uniprot id: F6PUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

13616:PGR
gene id: 13616:PGR
uniprot id: A0A5F8GJ62
uniprot id: F6Y601
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.

13616:CLCN7
gene id: 13616:CLCN7
uniprot id: A0A5F8GJW9
uniprot id: F6PY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

13616:TMCC2
gene id: 13616:TMCC2
uniprot id: F6WZC2
names: Similarity
messages: Belongs to the TEX28 family.

13616:LOC100030333
gene id: 13616:LOC100030333
uniprot id: F7CX27
names: Subcellular Location Annotation
messages: Membrane

13616:UBE2T
gene id: 13616:UBE2T
uniprot id: F6SUA7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:SLC35D2
gene id: 13616:SLC35D2
uniprot id: F6U9P9
names: Subcellular Location Annotation
messages: Membrane

13616:AKT3
gene id: 13616:AKT3
uniprot id: F7GEK1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

13616:SDC4
gene id: 13616:SDC4
uniprot id: A0A5F8GRG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

13616:LOC100024810
gene id: 13616:LOC100024810
uniprot id: F6VY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

13616:FFAR1
gene id: 13616:FFAR1
uniprot id: F6W8J7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:LOC100012425
gene id: 13616:LOC100012425
uniprot id: F6WLV8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

13616:LOC100010080
gene id: 13616:LOC100010080
uniprot id: F6PJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:KCND3
gene id: 13616:KCND3
uniprot id: A0A5F8G682
uniprot id: F7CIE1
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

13616:FAM83D
gene id: 13616:FAM83D
uniprot id: F6US57
names: Similarity
messages: Belongs to the FAM83 family.

13616:monDomV1R1233
gene id: 13616:monDomV1R1233
uniprot id: F7BV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100017630
gene id: 13616:LOC100017630
uniprot id: F7F7L5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

13616:LIMS1
gene id: 13616:LIMS1
uniprot id: A0A5F8GRJ2
uniprot id: A0A5F8H5W4
uniprot id: F7E2C4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

13616:TES
gene id: 13616:TES
uniprot id: Q2QLA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

13616:monDomV1R1269
gene id: 13616:monDomV1R1269
uniprot id: A0A5F8GKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:APOA1
gene id: 13616:APOA1
uniprot id: A0A5F8HJ22
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

13616:RBL2
gene id: 13616:RBL2
uniprot id: F6ZM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

13616:IFT43
gene id: 13616:IFT43
uniprot id: F7GGD2
names: Similarity
messages: Belongs to the IFT43 family.

13616:LOC100028963
gene id: 13616:LOC100028963
uniprot id: F7BJB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CCS
gene id: 13616:CCS
uniprot id: F6YJP8
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

13616:CPT2
gene id: 13616:CPT2
uniprot id: F6UAM7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

13616:PDE3B
gene id: 13616:PDE3B
uniprot id: F7FQK6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

13616:LOC100024672
gene id: 13616:LOC100024672
uniprot id: F6TXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: cytoskeleton

13616:HGF
gene id: 13616:HGF
uniprot id: A0A5F8GFC6
uniprot id: F6Y0F0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

13616:ACADS
gene id: 13616:ACADS
uniprot id: F6Q3F7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:TBX2
gene id: 13616:TBX2
uniprot id: F6TQY6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

13616:CLIC2
gene id: 13616:CLIC2
uniprot id: A0A5F8H1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

13616:CIAPIN1
gene id: 13616:CIAPIN1
uniprot id: F7D704
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

13616:EXOC3L4
gene id: 13616:EXOC3L4
uniprot id: F7CNI2
names: Similarity
messages: Belongs to the SEC6 family.

13616:EPHA7
gene id: 13616:EPHA7
uniprot id: F7CWR4
names: Subcellular Location Annotation
messages: Membrane

13616:SMIM19
gene id: 13616:SMIM19
uniprot id: F6WNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

13616:GRPEL2
gene id: 13616:GRPEL2
uniprot id: F6XY80
names: Similarity
messages: Belongs to the GrpE family.

13616:UGGT1
gene id: 13616:UGGT1
uniprot id: F7B290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

13616:LOC100618884
gene id: 13616:LOC100618884
uniprot id: F6XZ86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:KCNMB3
gene id: 13616:KCNMB3
uniprot id: F7G3H8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

13616:LOC100618909
gene id: 13616:LOC100618909
uniprot id: A0A5F8H9X9
names: Similarity
messages: Belongs to the perilipin family.

13616:LOC100014107
gene id: 13616:LOC100014107
uniprot id: A0A5F8HIR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DBR1
gene id: 13616:DBR1
uniprot id: A0A5F8GQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

13616:BEST4
gene id: 13616:BEST4
uniprot id: F7GF92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

13616:CXCL9
gene id: 13616:CXCL9
uniprot id: K7DZR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

13616:AMOT
gene id: 13616:AMOT
uniprot id: F6ZEG2
names: Similarity
messages: Belongs to the angiomotin family.

13616:LOC100018100
gene id: 13616:LOC100018100
uniprot id: F7FPL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

13616:MYO1D
gene id: 13616:MYO1D
uniprot id: A0A5F8G4F8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

13616:HABP4
gene id: 13616:HABP4
uniprot id: F7E764
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

13616:HSPD1
gene id: 13616:HSPD1
uniprot id: F7GF46
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

13616:GHR
gene id: 13616:GHR
uniprot id: Q9N0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

13616:IL7R
gene id: 13616:IL7R
uniprot id: F7FJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

13616:PRR15L
gene id: 13616:PRR15L
uniprot id: F7FVM6
names: Similarity
messages: Belongs to the PRR15 family.

13616:CFAP97D2
gene id: 13616:CFAP97D2
uniprot id: A0A5F8GF55
names: Similarity
messages: Belongs to the CFAP97 family.

13616:PROC
gene id: 13616:PROC
uniprot id: F7AEE9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:BTAF1
gene id: 13616:BTAF1
uniprot id: F7DH73
names: Subcellular Location Annotation
messages: Nucleus

13616:ERRFI1
gene id: 13616:ERRFI1
uniprot id: F7A9H2
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

13616:CCND2
gene id: 13616:CCND2
uniprot id: F6PTI2
names: Similarity
messages: Belongs to the cyclin family.

13616:PPIE
gene id: 13616:PPIE
uniprot id: F6YJW7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

13616:LOC100031208
gene id: 13616:LOC100031208
uniprot id: A0A5F8H9A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:VAMP4
gene id: 13616:VAMP4
uniprot id: F6ZJ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

13616:monDomV1R1274
gene id: 13616:monDomV1R1274
uniprot id: A0A5F8GQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:DGCR2
gene id: 13616:DGCR2
uniprot id: A0A5F8GQ68
uniprot id: F7EH13
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:SNAP47
gene id: 13616:SNAP47
uniprot id: F6X6M3
names: Similarity
messages: Belongs to the SVAP1 family.

13616:LOC100031151
gene id: 13616:LOC100031151
uniprot id: H9H621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CALB1
gene id: 13616:CALB1
uniprot id: F7BL42
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

13616:MFSD14B
gene id: 13616:MFSD14B
uniprot id: F6S9C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

13616:CCN1
gene id: 13616:CCN1
uniprot id: F6WAV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

13616:EFHC1
gene id: 13616:EFHC1
uniprot id: F6YYR9
names: Subcellular Location Annotation
messages: cilium axoneme

13616:CSGALNACT2
gene id: 13616:CSGALNACT2
uniprot id: F7G7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

13616:LIM2
gene id: 13616:LIM2
uniprot id: F6RM38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

13616:monDomV1R1202
gene id: 13616:monDomV1R1202
uniprot id: A0A5F8H1L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ZFYVE28
gene id: 13616:ZFYVE28
uniprot id: F7AES7
names: Similarity
messages: Belongs to the lst-2 family.

13616:CDNF
gene id: 13616:CDNF
uniprot id: A0A5F8GGW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

13616:SDAD1
gene id: 13616:SDAD1
uniprot id: A0A5F8HGM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

13616:ABI1
gene id: 13616:ABI1
uniprot id: A0A5F8GMF2
uniprot id: A0A5F8HFS0
uniprot id: A0A5F8HH61
uniprot id: A0A5F8HK55
uniprot id: F7FTR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

13616:PUF60
gene id: 13616:PUF60
uniprot id: F7ADW1
uniprot id: F7ADX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

13616:PRND
gene id: 13616:PRND
uniprot id: A2BDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

13616:LOC100010216
gene id: 13616:LOC100010216
uniprot id: F6Q499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

13616:TLCD3B
gene id: 13616:TLCD3B
uniprot id: F7DGI0
names: Subcellular Location Annotation
messages: Membrane

13616:NEDD9
gene id: 13616:NEDD9
uniprot id: A0A5F8G302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

13616:GAA
gene id: 13616:GAA
uniprot id: F7GEC6
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PEPD
gene id: 13616:PEPD
uniprot id: F7DI23
names: Similarity
messages: Belongs to the peptidase M24B family.

13616:OCLN
gene id: 13616:OCLN
uniprot id: F6SYJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

13616:CLDN19
gene id: 13616:CLDN19
uniprot id: F6QD11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

13616:DLGAP3
gene id: 13616:DLGAP3
uniprot id: F6TSK1
names: Similarity
messages: Belongs to the SAPAP family.

13616:CLRN3
gene id: 13616:CLRN3
uniprot id: F6PT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

13616:PKIA
gene id: 13616:PKIA
uniprot id: F7DH47
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

13616:PTGES
gene id: 13616:PTGES
uniprot id: A0A5F8H8C0
uniprot id: F7BTI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

13616:LOC100025159
gene id: 13616:LOC100025159
uniprot id: F6UKU7
names: Similarity
messages: Belongs to the serpin family.

13616:HMBS
gene id: 13616:HMBS
uniprot id: F6ZKA2
names: Similarity
messages: Belongs to the HMBS family.

13616:NANOG
gene id: 13616:NANOG
uniprot id: F7BUT7
names: Subcellular Location Annotation
messages: Nucleus

13616:MEGF11
gene id: 13616:MEGF11
uniprot id: A0A5F8GGU8
uniprot id: F6SYX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:HAGHL
gene id: 13616:HAGHL
uniprot id: A0A5F8GQ45
uniprot id: F7G5Y2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

13616:RICTOR
gene id: 13616:RICTOR
uniprot id: A0A5F8HBY7
uniprot id: F7G7I0
names: Similarity
messages: Belongs to the RICTOR family.

13616:MFSD9
gene id: 13616:MFSD9
uniprot id: A0A5F8GGS5
names: Subcellular Location Annotation
messages: Membrane

13616:QSOX1
gene id: 13616:QSOX1
uniprot id: A0A5F8GCP6
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

13616:MVB12B
gene id: 13616:MVB12B
uniprot id: A0A5F8GKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

13616:PGM3
gene id: 13616:PGM3
uniprot id: A0A5F8H855
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

13616:PPM1D
gene id: 13616:PPM1D
uniprot id: F6X2X9
names: Similarity
messages: Belongs to the PP2C family.

13616:NCLN
gene id: 13616:NCLN
uniprot id: F7EC67
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

13616:SIN3A
gene id: 13616:SIN3A
uniprot id: F7BFR8
names: Subcellular Location Annotation
messages: Nucleus

13616:SLCO1C1
gene id: 13616:SLCO1C1
uniprot id: A0A5F8H981
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:AASS
gene id: 13616:AASS
uniprot id: F6S3L1
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

13616:CERCAM
gene id: 13616:CERCAM
uniprot id: F6SKY7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

13616:ADCY8
gene id: 13616:ADCY8
uniprot id: A0A5F8GL47
uniprot id: F7BCI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

13616:LOC100019460
gene id: 13616:LOC100019460
uniprot id: F7FG79
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

13616:SYNE3
gene id: 13616:SYNE3
uniprot id: A0A5F8G5L1
names: Similarity
messages: Belongs to the nesprin family.

13616:NDE1
gene id: 13616:NDE1
uniprot id: F6SVX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

13616:FZD5
gene id: 13616:FZD5
uniprot id: F7G1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

13616:PSPC1
gene id: 13616:PSPC1
uniprot id: F7CKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

13616:TULP3
gene id: 13616:TULP3
uniprot id: F6PR86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

13616:monDomV1R1278
gene id: 13616:monDomV1R1278
uniprot id: A0A5F8HJM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HSF4
gene id: 13616:HSF4
uniprot id: F7C7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

13616:VN2R652
gene id: 13616:VN2R652
uniprot id: A0A5F8G297
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:OTULIN
gene id: 13616:OTULIN
uniprot id: F6PM51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

13616:CPXM2
gene id: 13616:CPXM2
uniprot id: F6YX02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

13616:SNRPA
gene id: 13616:SNRPA
uniprot id: F7GII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

13616:ITGB3
gene id: 13616:ITGB3
uniprot id: F7FW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

13616:DPF2
gene id: 13616:DPF2
uniprot id: A0A5F8GZE7
names: Similarity
messages: Belongs to the requiem/DPF family.

13616:BRS3
gene id: 13616:BRS3
uniprot id: F6R4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LRWD1
gene id: 13616:LRWD1
uniprot id: F6VF30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

13616:T2R3J
gene id: 13616:T2R3J
uniprot id: Q2ABA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:SLC25A19
gene id: 13616:SLC25A19
uniprot id: F7EF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

13616:LYAR
gene id: 13616:LYAR
uniprot id: F7F4L6
names: Subcellular Location Annotation
messages: Cytoplasm

13616:PPA2
gene id: 13616:PPA2
uniprot id: F7EMS4
names: Similarity
messages: Belongs to the PPase family.

13616:CCNB3
gene id: 13616:CCNB3
uniprot id: F6RLN2
names: Similarity
messages: Belongs to the cyclin family.

13616:LOC100029137
gene id: 13616:LOC100029137
uniprot id: A0A5F8G6P6
names: Similarity
messages: Belongs to the cytochrome P450 family.

13616:USP14
gene id: 13616:USP14
uniprot id: F7G2Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

13616:KPNA5
gene id: 13616:KPNA5
uniprot id: A0A5F8HEX0
uniprot id: F6ZXA8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

13616:LSM1
gene id: 13616:LSM1
uniprot id: A0A5F8GDB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

13616:LOC100026693
gene id: 13616:LOC100026693
uniprot id: F7FVE9
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

13616:LOC100026087
gene id: 13616:LOC100026087
uniprot id: F6TDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

13616:CD163
gene id: 13616:CD163
uniprot id: F7ENX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100030117
gene id: 13616:LOC100030117
uniprot id: A0A5F8G9C1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

13616:T2R3D
gene id: 13616:T2R3D
uniprot id: Q2ABA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

13616:LOC100032991
gene id: 13616:LOC100032991
uniprot id: F7CND5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100012481
gene id: 13616:LOC100012481
uniprot id: F6Z4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:GNG8
gene id: 13616:GNG8
uniprot id: F6YZA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

13616:AIG1
gene id: 13616:AIG1
uniprot id: F6T3Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

13616:MOK
gene id: 13616:MOK
uniprot id: F7GJG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:TMEM150C
gene id: 13616:TMEM150C
uniprot id: A0A5F8HA54
uniprot id: F7DER9
names: Subcellular Location Annotation
messages: Membrane

13616:PAQR5
gene id: 13616:PAQR5
uniprot id: A0A5F8GD34
uniprot id: A0A5F8H5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

13616:EDEM1
gene id: 13616:EDEM1
uniprot id: F6R5E1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

13616:ARGLU1
gene id: 13616:ARGLU1
uniprot id: F7FHF8
names: Similarity
messages: Belongs to the UPF0430 family.

13616:CUL4A
gene id: 13616:CUL4A
uniprot id: F7G925
names: Similarity
messages: Belongs to the cullin family.

13616:LOC100021638
gene id: 13616:LOC100021638
uniprot id: F6SKZ7
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

13616:TMEM265
gene id: 13616:TMEM265
uniprot id: A0A5F8HGV3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:LOC100010666
gene id: 13616:LOC100010666
uniprot id: A0A5F8G700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MTX2
gene id: 13616:MTX2
uniprot id: F6RZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

13616:LOC100021601
gene id: 13616:LOC100021601
uniprot id: A0A5F8HCU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:HOXB5
gene id: 13616:HOXB5
uniprot id: F7E2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

13616:PHKA2
gene id: 13616:PHKA2
uniprot id: A0A5F8GDV0
uniprot id: A0A5F8GQY9
uniprot id: F6UJJ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

13616:TGFBR1
gene id: 13616:TGFBR1
uniprot id: F6VGC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

13616:TAF4B
gene id: 13616:TAF4B
uniprot id: F7FSG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

13616:SNUPN
gene id: 13616:SNUPN
uniprot id: F7CUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

13616:HLX
gene id: 13616:HLX
uniprot id: F6U7F3
names: Subcellular Location Annotation
messages: Nucleus

13616:RORA
gene id: 13616:RORA
uniprot id: F6QXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

13616:LOC100025070
gene id: 13616:LOC100025070
uniprot id: F6SVP6
names: Subcellular Location Annotation
messages: extracellular matrix

13616:IDS
gene id: 13616:IDS
uniprot id: F7DJA1
names: Similarity
messages: Belongs to the sulfatase family.

13616:HMGN2
gene id: 13616:HMGN2
uniprot id: F7GFJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

13616:KATNAL2
gene id: 13616:KATNAL2
uniprot id: A0A5F8G4S8
uniprot id: F6ZPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

13616:TMPO
gene id: 13616:TMPO
uniprot id: A0A5F8G4Y9
uniprot id: F6X3L4
names: Similarity
messages: Belongs to the LEM family.

13616:ITGB4
gene id: 13616:ITGB4
uniprot id: A0A5F8G3D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

13616:LOC100016035
gene id: 13616:LOC100016035
uniprot id: F7CQE9
names: Similarity
messages: Belongs to the centrin family.

13616:MAP1LC3C
gene id: 13616:MAP1LC3C
uniprot id: A0A5F8GEG0
names: Similarity
messages: Belongs to the ATG8 family.

13616:LOC100030404
gene id: 13616:LOC100030404
uniprot id: F6ZP21
names: Subcellular Location Annotation
messages: Membrane

13616:HACD4
gene id: 13616:HACD4
uniprot id: F7AZ94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:DOK3
gene id: 13616:DOK3
uniprot id: F6U708
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

13616:EMC3
gene id: 13616:EMC3
uniprot id: F6YL58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

13616:NT5DC4
gene id: 13616:NT5DC4
uniprot id: F6WPC8
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

13616:TFPI
gene id: 13616:TFPI
uniprot id: F7C0N5
names: Subcellular Location Annotation
messages: Secreted

13616:LGI1
gene id: 13616:LGI1
uniprot id: A0A5F8H271
uniprot id: F6XG60
names: Subcellular Location Annotation
messages: Secreted

13616:PHOSPHO1
gene id: 13616:PHOSPHO1
uniprot id: A0A5F8HIA0
uniprot id: F7CE09
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

13616:USE1
gene id: 13616:USE1
uniprot id: F7G5D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:CDCA2
gene id: 13616:CDCA2
uniprot id: F7D1W5
names: Subcellular Location Annotation
messages: Nucleus

13616:PARK7
gene id: 13616:PARK7
uniprot id: A0A5F8HEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

13616:ACTG2
gene id: 13616:ACTG2
uniprot id: F7DQK7
names: Similarity
messages: Belongs to the actin family.

13616:SVOPL
gene id: 13616:SVOPL
uniprot id: F6SXC8
names: Subcellular Location Annotation
messages: Membrane

13616:LOC100032302
gene id: 13616:LOC100032302
uniprot id: F6VUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

13616:ADGRE5
gene id: 13616:ADGRE5
uniprot id: A0A5F8HIY9
uniprot id: F7E0D4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:RGS4
gene id: 13616:RGS4
uniprot id: F7GHB2
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

13616:SEPSECS
gene id: 13616:SEPSECS
uniprot id: F6VAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

13616:PRKAA1
gene id: 13616:PRKAA1
uniprot id: F7BFG2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

13616:SEPHS1
gene id: 13616:SEPHS1
uniprot id: F6Y2T3
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

13616:LANCL1
gene id: 13616:LANCL1
uniprot id: F7FRY9
names: Similarity
messages: Belongs to the LanC-like protein family.

13616:SLC4A10
gene id: 13616:SLC4A10
uniprot id: A0A5F8G5N6
uniprot id: A0A5F8GT71
uniprot id: A0A5F8H6Z8
uniprot id: F7EC31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

13616:DMRT2
gene id: 13616:DMRT2
uniprot id: F7GCC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:USP9X
gene id: 13616:USP9X
uniprot id: F6UID4
names: Similarity
messages: Belongs to the peptidase C19 family.

13616:CASS4
gene id: 13616:CASS4
uniprot id: F6XQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

13616:HTR1B
gene id: 13616:HTR1B
uniprot id: F6T6U1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

13616:VN2R528
gene id: 13616:VN2R528
uniprot id: F6Z9G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CRB2
gene id: 13616:CRB2
uniprot id: F6X3Y3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:PLEKHA8
gene id: 13616:PLEKHA8
uniprot id: F6QD02
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

13616:GREB1L
gene id: 13616:GREB1L
uniprot id: F7GK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

13616:ARHGEF12
gene id: 13616:ARHGEF12
uniprot id: A0A5F8GN29
uniprot id: F7B035
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

13616:LOC100032402
gene id: 13616:LOC100032402
uniprot id: A0A5F8GEU7
names: Similarity
messages: Belongs to the intermediate filament family.

13616:AGT
gene id: 13616:AGT
uniprot id: F6Z008
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

13616:IRX2
gene id: 13616:IRX2
uniprot id: F6R2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

13616:LOC100026534
gene id: 13616:LOC100026534
uniprot id: F6WU37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:UNC50
gene id: 13616:UNC50
uniprot id: A0A5F8GYM5
uniprot id: A0A5F8HET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

13616:PHTF2
gene id: 13616:PHTF2
uniprot id: A0A5F8GCD3
names: Subcellular Location Annotation
messages: Membrane

13616:UFC1
gene id: 13616:UFC1
uniprot id: F7E6W2
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

13616:SNX32
gene id: 13616:SNX32
uniprot id: F6ZNH6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

13616:PPP4R3A
gene id: 13616:PPP4R3A
uniprot id: A0A5F8GGB6
names: Similarity
messages: Belongs to the SMEK family.

13616:FN1
gene id: 13616:FN1
uniprot id: A0A5F8G575
uniprot id: A0A5F8GJ00
uniprot id: A0A5F8H7U7
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

13616:LOC100013197
gene id: 13616:LOC100013197
uniprot id: A0A5F8G4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

13616:DIPK1C
gene id: 13616:DIPK1C
uniprot id: F7DHI4
names: Similarity
messages: Belongs to the DIPK family.

13616:POGLUT2
gene id: 13616:POGLUT2
uniprot id: F6SKB2
names: Similarity
messages: Belongs to the KDELC family.

13616:FZD6
gene id: 13616:FZD6
uniprot id: F7CZ56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:GPC4
gene id: 13616:GPC4
uniprot id: F6QDK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

13616:TTC36
gene id: 13616:TTC36
uniprot id: F7G9C7
names: Similarity
messages: Belongs to the TTC36 family.

13616:monDomV1R1252
gene id: 13616:monDomV1R1252
uniprot id: A0A5F8GJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PITHD1
gene id: 13616:PITHD1
uniprot id: F7D6T5
names: Similarity
messages: Belongs to the PITHD1 family.

13616:SLC1A5
gene id: 13616:SLC1A5
uniprot id: F6QQG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

13616:NME1
gene id: 13616:NME1
uniprot id: A0A5F8GG11
uniprot id: F6PIN1
names: Similarity
messages: Belongs to the NDK family.

13616:INSR
gene id: 13616:INSR
uniprot id: A0A5F8GJ01
uniprot id: F7F370
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

13616:CKB
gene id: 13616:CKB
uniprot id: A0A5F8HCG0
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

13616:EFHC2
gene id: 13616:EFHC2
uniprot id: F6UIX5
names: Subcellular Location Annotation
messages: cilium axoneme

13616:LANCL2
gene id: 13616:LANCL2
uniprot id: F7G210
names: Similarity
messages: Belongs to the LanC-like protein family.

13616:GIMAP6
gene id: 13616:GIMAP6
uniprot id: A0A5F8H098
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

13616:SULT1A2
gene id: 13616:SULT1A2
uniprot id: F7F0U2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:HNF1A
gene id: 13616:HNF1A
uniprot id: F6Q5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

13616:IMP4
gene id: 13616:IMP4
uniprot id: F7GI18
names: Subcellular Location Annotation
messages: nucleolus

13616:TEX10
gene id: 13616:TEX10
uniprot id: F6S2L8
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

13616:FGA
gene id: 13616:FGA
uniprot id: F7CJ60
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

13616:DHX15
gene id: 13616:DHX15
uniprot id: F6Y5H8
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

13616:ADPRH
gene id: 13616:ADPRH
uniprot id: A0A5F8H0D8
uniprot id: A0A5F8H729
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

13616:SIGMAR1
gene id: 13616:SIGMAR1
uniprot id: F7GIA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

13616:SPG21
gene id: 13616:SPG21
uniprot id: F6YT13
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

13616:GET1
gene id: 13616:GET1
uniprot id: A0A5F8GGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

13616:ADAM12
gene id: 13616:ADAM12
uniprot id: F6ZF10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:TSN
gene id: 13616:TSN
uniprot id: F6XTG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

13616:P4HA3
gene id: 13616:P4HA3
uniprot id: F6YZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

13616:LOC103096099
gene id: 13616:LOC103096099
uniprot id: A0A5F8G7N1
uniprot id: A0A5F8G9B7
uniprot id: A0A5F8HDW3
names: Function
names: Similarity
messages: Belongs to the SPATA31 family.
messages: Major early eggshell protein.

13616:DBNDD2
gene id: 13616:DBNDD2
uniprot id: F7G8N2
names: Similarity
messages: Belongs to the dysbindin family.

13616:STARD8
gene id: 13616:STARD8
uniprot id: A0A5F8H0U1
names: Subcellular Location Annotation
messages: Cytoplasm

13616:LOC100028976
gene id: 13616:LOC100028976
uniprot id: F6UAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

13616:DPP7
gene id: 13616:DPP7
uniprot id: A0A5F8H1Q0
names: Similarity
messages: Belongs to the peptidase S28 family.

13616:TSC22D2
gene id: 13616:TSC22D2
uniprot id: A0A5F8GSA9
uniprot id: F6T2U7
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

13616:TARS2
gene id: 13616:TARS2
uniprot id: F6ZNQ0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

13616:COPB2
gene id: 13616:COPB2
uniprot id: F7BQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

13616:LOC100032458
gene id: 13616:LOC100032458
uniprot id: F6SWW7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

13616:MRPL9
gene id: 13616:MRPL9
uniprot id: F7CQD1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

13616:ENGASE
gene id: 13616:ENGASE
uniprot id: F6QW59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

13616:PLET1
gene id: 13616:PLET1
uniprot id: F6UHU8
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

13616:FOXO6
gene id: 13616:FOXO6
uniprot id: F6WVS4
names: Subcellular Location Annotation
messages: Nucleus

13616:ABCB11
gene id: 13616:ABCB11
uniprot id: F7ETR3
names: Subcellular Location Annotation
messages: Membrane

13616:GPHB5
gene id: 13616:GPHB5
uniprot id: F7GCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

13616:RAB14
gene id: 13616:RAB14
uniprot id: F7DD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

13616:RANBP10
gene id: 13616:RANBP10
uniprot id: A0A5F8G6J2
uniprot id: F7CZC7
names: Similarity
messages: Belongs to the RANBP9/10 family.

13616:FAN1
gene id: 13616:FAN1
uniprot id: A0A5F8HHL9
uniprot id: F7CBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

13616:monDomV1R1206
gene id: 13616:monDomV1R1206
uniprot id: A0A5F8HLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC52A3
gene id: 13616:SLC52A3
uniprot id: F6Z2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

13616:GNRHR
gene id: 13616:GNRHR
uniprot id: F7A026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:LOC100024120
gene id: 13616:LOC100024120
uniprot id: F7GBZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LHFPL1
gene id: 13616:LHFPL1
uniprot id: F6ZDS8
names: Subcellular Location Annotation
messages: Membrane

13616:FAIM2
gene id: 13616:FAIM2
uniprot id: F6SX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

13616:PTAR1
gene id: 13616:PTAR1
uniprot id: F7EJ46
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

13616:UBE2L3
gene id: 13616:UBE2L3
uniprot id: A0A5F8GNU3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

13616:C7H7orf25
gene id: 13616:C7H7orf25
uniprot id: H9H9Q0
names: Similarity
messages: Belongs to the UPF0415 family.

13616:RAPGEF6
gene id: 13616:RAPGEF6
uniprot id: A0A5F8HFI1
names: Similarity
messages: Belongs to the RAPGEF2 family.

13616:HNRNPA2B1
gene id: 13616:HNRNPA2B1
uniprot id: F6TBC0
names: Subcellular Location Annotation
messages: Cytoplasmic granule

13616:CREBBP
gene id: 13616:CREBBP
uniprot id: F7E905
names: Subcellular Location Annotation
messages: Cytoplasm

13616:AP2B1
gene id: 13616:AP2B1
uniprot id: A0A5F8GR62
uniprot id: F7EUM5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

13616:TMEM192
gene id: 13616:TMEM192
uniprot id: F7CWE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

13616:TLCD3A
gene id: 13616:TLCD3A
uniprot id: F6TT94
names: Subcellular Location Annotation
messages: Membrane

13616:DMRTA2
gene id: 13616:DMRTA2
uniprot id: F7CJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

13616:SLAIN1
gene id: 13616:SLAIN1
uniprot id: A0A5F8G2F5
uniprot id: F7FHX9
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

13616:HSD17B7
gene id: 13616:HSD17B7
uniprot id: F7GHF2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

13616:CORIN
gene id: 13616:CORIN
uniprot id: F6ZAT4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:BTBD10
gene id: 13616:BTBD10
uniprot id: A0A5F8GKR9
uniprot id: A0A5F8HDX5
names: Subcellular Location Annotation
messages: Cytoplasm

13616:ELK4
gene id: 13616:ELK4
uniprot id: F6T5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

13616:CMTM4
gene id: 13616:CMTM4
uniprot id: F6PVR9
names: Subcellular Location Annotation
messages: Membrane

13616:SLC12A5
gene id: 13616:SLC12A5
uniprot id: F6WQ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

13616:monDomV1R1250
gene id: 13616:monDomV1R1250
uniprot id: A0A5F8H0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CTSA
gene id: 13616:CTSA
uniprot id: F6YAH2
names: Similarity
messages: Belongs to the peptidase S10 family.

13616:LOC100017091
gene id: 13616:LOC100017091
uniprot id: F6YZH5
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

13616:GCDH
gene id: 13616:GCDH
uniprot id: F6V0X1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

13616:MRPL19
gene id: 13616:MRPL19
uniprot id: F7DQT5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

13616:GHRH
gene id: 13616:GHRH
uniprot id: A0A5F8G7T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

13616:CDS2
gene id: 13616:CDS2
uniprot id: A0A5F8HGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

13616:LOC100012815
gene id: 13616:LOC100012815
uniprot id: A0A5F8GB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ANAPC15
gene id: 13616:ANAPC15
uniprot id: F6Z9Y0
names: Similarity
messages: Belongs to the APC15 family.

13616:EIF1B
gene id: 13616:EIF1B
uniprot id: F7DF53
names: Similarity
messages: Belongs to the SUI1 family.

13616:LOC100029911
gene id: 13616:LOC100029911
uniprot id: F6Z8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

13616:CXCR4
gene id: 13616:CXCR4
uniprot id: A0A5F8GXR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

13616:CHMP4B
gene id: 13616:CHMP4B
uniprot id: F7EIX3
names: Similarity
messages: Belongs to the SNF7 family.

13616:ATP6V1F
gene id: 13616:ATP6V1F
uniprot id: A0A5F8GU20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

13616:LOC100013013
gene id: 13616:LOC100013013
uniprot id: A0A5F8H0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:MAP1LC3A
gene id: 13616:MAP1LC3A
uniprot id: F7CYB7
names: Similarity
messages: Belongs to the ATG8 family.

13616:SLC25A25
gene id: 13616:SLC25A25
uniprot id: A0A5F8G207
uniprot id: A0A5F8GBG4
uniprot id: A0A5F8GQJ4
uniprot id: F6QEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

13616:DIPK1A
gene id: 13616:DIPK1A
uniprot id: F6U180
names: Similarity
messages: Belongs to the DIPK family.

13616:UBN1
gene id: 13616:UBN1
uniprot id: A0A5F8GJI6
uniprot id: A0A5F8H220
names: Similarity
messages: Belongs to the ubinuclein family.

13616:LOC100014496
gene id: 13616:LOC100014496
uniprot id: F7G7A3
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

13616:ADAMTS2
gene id: 13616:ADAMTS2
uniprot id: F7GAM5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

13616:GTF2F2
gene id: 13616:GTF2F2
uniprot id: F6QZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

13616:CADM3
gene id: 13616:CADM3
uniprot id: A0A5F8GNW5
names: Similarity
messages: Belongs to the nectin family.

13616:CCT2
gene id: 13616:CCT2
uniprot id: F7F689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

13616:ANXA2
gene id: 13616:ANXA2
uniprot id: F6UHK2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

13616:ZNF408
gene id: 13616:ZNF408
uniprot id: F6W5U6
names: Subcellular Location Annotation
messages: Nucleus

13616:POLG2
gene id: 13616:POLG2
uniprot id: F7FAA1
names: Subcellular Location Annotation
messages: Mitochondrion

13616:ASAH1
gene id: 13616:ASAH1
uniprot id: F7BKX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

13616:UPK1B
gene id: 13616:UPK1B
uniprot id: F7B797
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

13616:SLCO5A1
gene id: 13616:SLCO5A1
uniprot id: F7GKH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:SLC27A2
gene id: 13616:SLC27A2
uniprot id: F6YDA1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

13616:INPP4A
gene id: 13616:INPP4A
uniprot id: A0A5F8GHV0
uniprot id: F7GHC4
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

13616:DPCD
gene id: 13616:DPCD
uniprot id: F7DFJ0
names: Similarity
messages: Belongs to the DPCD family.

13616:ARPC1A
gene id: 13616:ARPC1A
uniprot id: F7BZM9
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

13616:OXA1L
gene id: 13616:OXA1L
uniprot id: F7CH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

13616:GRIK3
gene id: 13616:GRIK3
uniprot id: F7CFG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

13616:SRD5A3
gene id: 13616:SRD5A3
uniprot id: A0A5F8H8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

13616:PAX9
gene id: 13616:PAX9
uniprot id: F6VG93
names: Subcellular Location Annotation
messages: Nucleus

13616:SLC66A2
gene id: 13616:SLC66A2
uniprot id: A0A5F8HDI0
uniprot id: F7B9T8
names: Subcellular Location Annotation
messages: Membrane

13616:TAC3
gene id: 13616:TAC3
uniprot id: H9H7C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

13616:LOC100011182
gene id: 13616:LOC100011182
uniprot id: F6PX60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

13616:CELF3
gene id: 13616:CELF3
uniprot id: A0A5F8GYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

13616:CPLX1
gene id: 13616:CPLX1
uniprot id: F6VKP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

13616:DUSP5
gene id: 13616:DUSP5
uniprot id: A0A5F8GZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

13616:CEBPA
gene id: 13616:CEBPA
uniprot id: F7CYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

13616:MTTP
gene id: 13616:MTTP
uniprot id: F7BAZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:RPS14
gene id: 13616:RPS14
uniprot id: F7FN91
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

13616:PGM5
gene id: 13616:PGM5
uniprot id: F6WUY4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

13616:PIGH
gene id: 13616:PIGH
uniprot id: A0A5F8G8T6
names: Similarity
messages: Belongs to the PIGH family.

13616:PGAP6
gene id: 13616:PGAP6
uniprot id: F7E6Q5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

13616:UBE3A
gene id: 13616:UBE3A
uniprot id: A0A5F8HFE2
uniprot id: F7A2Q4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

13616:C4BPB
gene id: 13616:C4BPB
uniprot id: F7G3E0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:IZUMO1R
gene id: 13616:IZUMO1R
uniprot id: F7AHC3
names: Similarity
messages: Belongs to the folate receptor family.

13616:VTA1
gene id: 13616:VTA1
uniprot id: A0A5F8G2Q5
uniprot id: A0A5F8HK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

13616:UBA52
gene id: 13616:UBA52
uniprot id: F7CRY4
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

13616:LOC103095354
gene id: 13616:LOC103095354
uniprot id: F7F0X2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

13616:HOXB9
gene id: 13616:HOXB9
uniprot id: F7E2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

13616:SET
gene id: 13616:SET
uniprot id: F7AFN2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

13616:AP1S3
gene id: 13616:AP1S3
uniprot id: A0A5F8H848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

13616:DDRGK1
gene id: 13616:DDRGK1
uniprot id: A0A5F8G8I2
names: Similarity
messages: Belongs to the DDRGK1 family.

13616:LOC100019389
gene id: 13616:LOC100019389
uniprot id: F6WYU4
names: Similarity
messages: Belongs to the globin family.

13616:LOC100618597
gene id: 13616:LOC100618597
uniprot id: F7D893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:monDomV1R1230
gene id: 13616:monDomV1R1230
uniprot id: A0A5F8GPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:CHMP3
gene id: 13616:CHMP3
uniprot id: F7FNS4
names: Similarity
messages: Belongs to the SNF7 family.

13616:EHD3
gene id: 13616:EHD3
uniprot id: F6VZL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

13616:SEC23B
gene id: 13616:SEC23B
uniprot id: F6V3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

13616:NIF3L1
gene id: 13616:NIF3L1
uniprot id: F7FUK4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

13616:FAM171B
gene id: 13616:FAM171B
uniprot id: F7CKF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

13616:LOC100027035
gene id: 13616:LOC100027035
uniprot id: F6PJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ATP5MC1
gene id: 13616:ATP5MC1
uniprot id: A0A5F8GA93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

13616:CDH3
gene id: 13616:CDH3
uniprot id: F7EGB5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

13616:ZDHHC16
gene id: 13616:ZDHHC16
uniprot id: A0A5F8G6H2
uniprot id: F6QNX2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

13616:TBC1D31
gene id: 13616:TBC1D31
uniprot id: F6YEK7
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

13616:TSR3
gene id: 13616:TSR3
uniprot id: F7FYA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:LOC100017002
gene id: 13616:LOC100017002
uniprot id: A0A5F8HD01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SUMO1
gene id: 13616:SUMO1
uniprot id: A0A5F8GJB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

13616:monDomV1R1203
gene id: 13616:monDomV1R1203
uniprot id: A0A5F8HBQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:TLR2
gene id: 13616:TLR2
uniprot id: F6UTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

13616:CCDC85A
gene id: 13616:CCDC85A
uniprot id: A0A5F8GEQ2
uniprot id: A0A5F8H9J9
uniprot id: A0A5F8HD03
uniprot id: F6QCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

13616:LOC100019817
gene id: 13616:LOC100019817
uniprot id: A0A5F8G6G9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

13616:VN2R572
gene id: 13616:VN2R572
uniprot id: A0A5F8G923
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:CD164
gene id: 13616:CD164
uniprot id: F7BUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

13616:CSNK2B
gene id: 13616:CSNK2B
uniprot id: A0A5F8GWR8
uniprot id: A0A5F8HE66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

13616:RPGRIP1L
gene id: 13616:RPGRIP1L
uniprot id: A0A5F8H3D1
names: Similarity
messages: Belongs to the RPGRIP1 family.

13616:APMAP
gene id: 13616:APMAP
uniprot id: F7BQY7
names: Similarity
messages: Belongs to the strictosidine synthase family.

13616:ZAR1L
gene id: 13616:ZAR1L
uniprot id: F7FZE4
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

13616:TMEM151B
gene id: 13616:TMEM151B
uniprot id: A0A5F8H4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

13616:VPS33B
gene id: 13616:VPS33B
uniprot id: F6VUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

13616:ABRACL
gene id: 13616:ABRACL
uniprot id: F6SM16
names: Similarity
messages: Belongs to the costars family.

13616:MRPL33
gene id: 13616:MRPL33
uniprot id: F6ZV32
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

13616:PNPLA1
gene id: 13616:PNPLA1
uniprot id: F7AVV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

13616:POLR2A
gene id: 13616:POLR2A
uniprot id: F6XTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

13616:ST8SIA3
gene id: 13616:ST8SIA3
uniprot id: F7AQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

13616:LOC100030110
gene id: 13616:LOC100030110
uniprot id: K7E501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:SLC6A18
gene id: 13616:SLC6A18
uniprot id: F6ZGL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

13616:LOC100021613
gene id: 13616:LOC100021613
uniprot id: F6SLC4
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

13616:MIEF2
gene id: 13616:MIEF2
uniprot id: F6QNZ2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

13616:LOC100021084
gene id: 13616:LOC100021084
uniprot id: F6RPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:PEX13
gene id: 13616:PEX13
uniprot id: F7DG26
names: Similarity
messages: Belongs to the peroxin-13 family.

13616:SLC35B3
gene id: 13616:SLC35B3
uniprot id: A0A5F8GZN9
uniprot id: F6TTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

13616:LOC100023806
gene id: 13616:LOC100023806
uniprot id: F6ZH23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:ARPC4
gene id: 13616:ARPC4
uniprot id: F7EQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

13616:SMARCA4
gene id: 13616:SMARCA4
uniprot id: F7CAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

13616:CTPS1
gene id: 13616:CTPS1
uniprot id: F6WFF7
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

13616:IFITM5
gene id: 13616:IFITM5
uniprot id: H9H7W4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

13616:LOC100619324
gene id: 13616:LOC100619324
uniprot id: F6T9S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

13616:NAXE
gene id: 13616:NAXE
uniprot id: F7FIH8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
messages: Homodimer (By similarity). Interacts with APOA1 and APOA2 (By similarity).
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

13616:FLVCR1
gene id: 13616:FLVCR1
uniprot id: A0A5F8HI92
names: Subcellular Location Annotation
messages: Membrane

13616:NMUR1
gene id: 13616:NMUR1
uniprot id: F7BW40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

13616:ACTR3B
gene id: 13616:ACTR3B
uniprot id: F6TPU3
names: Similarity
messages: Belongs to the actin family.

13616:PDIK1L
gene id: 13616:PDIK1L
uniprot id: A0A5F8H7B2
names: Similarity
messages: Belongs to the protein kinase superfamily.

13616:ABCA1
gene id: 13616:ABCA1
uniprot id: F7BHC7
names: Subcellular Location Annotation
messages: Membrane

13616:RET
gene id: 13616:RET
uniprot id: F7G7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

13616:LOC100018839
gene id: 13616:LOC100018839
uniprot id: A0A5F8GFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

13616:monDomV1R1234
gene id: 13616:monDomV1R1234
uniprot id: F7EX64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

13616:INTS3
gene id: 13616:INTS3
uniprot id: F6VZW0
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

13616:RC3H2
gene id: 13616:RC3H2
uniprot id: A0A5F8H8X0
names: Similarity
messages: Belongs to the phosducin family.

13616:SMPD1
gene id: 13616:SMPD1
uniprot id: F7FD53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

13616:KIF24
gene id: 13616:KIF24
uniprot id: A0A5F8GX18
uniprot id: K7E100
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

13616:GKAP1
gene id: 13616:GKAP1
uniprot id: F7FTQ9
names: Similarity
messages: Belongs to the GKAP1 family.

13616:VN2R551
gene id: 13616:VN2R551
uniprot id: A0A5F8GQV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

13616:SMIM5
gene id: 13616:SMIM5
uniprot id: A0A5F8HK56
names: Subcellular Location Annotation
messages: Membrane