1348662:CARG RS07390
gene id: 1348662:CARG_RS07390
uniprot id: U3GVV0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1348662:CARG RS08180
gene id: 1348662:CARG_RS08180
uniprot id: U3GW62
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

1348662:CARG RS06965
gene id: 1348662:CARG_RS06965
uniprot id: U3GYY2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1348662:CARG RS07535
gene id: 1348662:CARG_RS07535
uniprot id: U3GVX7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

1348662:CARG RS05615
gene id: 1348662:CARG_RS05615
uniprot id: U3GVC6
names: Similarity
messages: Belongs to the PspA/IM30 family.

1348662:CARG RS06305
gene id: 1348662:CARG_RS06305
uniprot id: U3GXV2
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1348662:CARG RS05030
gene id: 1348662:CARG_RS05030
uniprot id: U3GUL3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1348662:CARG RS07230
gene id: 1348662:CARG_RS07230
uniprot id: U3GY63
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1348662:CARG RS06055
gene id: 1348662:CARG_RS06055
uniprot id: U3GV19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06580
gene id: 1348662:CARG_RS06580
uniprot id: U3GVV8
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

1348662:CARG RS01040
gene id: 1348662:CARG_RS01040
uniprot id: U3GWQ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06740
gene id: 1348662:CARG_RS06740
uniprot id: U3GZP9
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05655
gene id: 1348662:CARG_RS05655
uniprot id: U3GZI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1348662:CARG RS06680
gene id: 1348662:CARG_RS06680
uniprot id: U3GVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1348662:CARG RS05430
gene id: 1348662:CARG_RS05430
uniprot id: U3GV96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1348662:CARG RS01340
gene id: 1348662:CARG_RS01340
uniprot id: U3GVG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS00940
gene id: 1348662:CARG_RS00940
uniprot id: U3GSV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS05235
gene id: 1348662:CARG_RS05235
uniprot id: U3GYB9
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1348662:CARG RS06495
gene id: 1348662:CARG_RS06495
uniprot id: U3GZN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

1348662:CARG RS08130
gene id: 1348662:CARG_RS08130
uniprot id: U3GS35
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1348662:CARG RS02275
gene id: 1348662:CARG_RS02275
uniprot id: U3GTJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

1348662:CARG RS03780
gene id: 1348662:CARG_RS03780
uniprot id: U3GXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

1348662:CARG RS03940
gene id: 1348662:CARG_RS03940
uniprot id: U3GWW0
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS01425
gene id: 1348662:CARG_RS01425
uniprot id: U3GSP7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1348662:CARG RS03080
gene id: 1348662:CARG_RS03080
uniprot id: U3GYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

1348662:CARG RS04230
gene id: 1348662:CARG_RS04230
uniprot id: U3GX16
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1348662:CARG RS00375
gene id: 1348662:CARG_RS00375
uniprot id: U3GWD1
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1348662:CARG RS01815
gene id: 1348662:CARG_RS01815
uniprot id: U3GVP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1348662:CARG RS01525
gene id: 1348662:CARG_RS01525
uniprot id: U3GVI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1348662:CARG RS05980
gene id: 1348662:CARG_RS05980
uniprot id: U3GVJ4
names: Similarity
messages: Belongs to the P(II) protein family.

1348662:CARG RS05095
gene id: 1348662:CARG_RS05095
uniprot id: U3GXH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1348662:CARG RS07820
gene id: 1348662:CARG_RS07820
uniprot id: U3GZV0
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03350
gene id: 1348662:CARG_RS03350
uniprot id: U3GTN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

1348662:CARG RS04270
gene id: 1348662:CARG_RS04270
uniprot id: U3GY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1348662:CARG RS01515
gene id: 1348662:CARG_RS01515
uniprot id: U3GSR0
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1348662:CARG RS07605
gene id: 1348662:CARG_RS07605
uniprot id: U3GWJ3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1348662:CARG RS06430
gene id: 1348662:CARG_RS06430
uniprot id: U3GXW8
names: Similarity
messages: Belongs to the YjdM family.

1348662:CARG RS04700
gene id: 1348662:CARG_RS04700
uniprot id: U3GY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

1348662:CARG RS05180
gene id: 1348662:CARG_RS05180
uniprot id: U3GUN2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1348662:CARG RS08395
gene id: 1348662:CARG_RS08395
uniprot id: U3GW97
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1348662:CARG RS03155
gene id: 1348662:CARG_RS03155
uniprot id: U3GYV4
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1348662:CARG RS01335
gene id: 1348662:CARG_RS01335
uniprot id: U3GUQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1348662:CARG RS01635
gene id: 1348662:CARG_RS01635
uniprot id: U3GVK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1348662:CARG RS03130
gene id: 1348662:CARG_RS03130
uniprot id: U3GYV0
names: Caution
names: Similarity
messages: Belongs to the acetaldehyde dehydrogenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS00425
gene id: 1348662:CARG_RS00425
uniprot id: U3GUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1348662:CARG RS05155
gene id: 1348662:CARG_RS05155
uniprot id: U3GUN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1348662:CARG RS04100
gene id: 1348662:CARG_RS04100
uniprot id: U3GWZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS05130
gene id: 1348662:CARG_RS05130
uniprot id: U3GUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1348662:CARG RS05575
gene id: 1348662:CARG_RS05575
uniprot id: U3GZH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07355
gene id: 1348662:CARG_RS07355
uniprot id: U3GY79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1348662:CARG RS04395
gene id: 1348662:CARG_RS04395
uniprot id: U3GU91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06555
gene id: 1348662:CARG_RS06555
uniprot id: U3GVV5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1348662:CARG RS01230
gene id: 1348662:CARG_RS01230
uniprot id: U3GUQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1348662:CARG RS04595
gene id: 1348662:CARG_RS04595
uniprot id: U3GUR4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1348662:CARG RS07165
gene id: 1348662:CARG_RS07165
uniprot id: U3GVQ4
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS04470
gene id: 1348662:CARG_RS04470
uniprot id: U3GUN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1348662:CARG RS06200
gene id: 1348662:CARG_RS06200
uniprot id: U3GZM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

1348662:CARG RS07470
gene id: 1348662:CARG_RS07470
uniprot id: U3GWH3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1348662:CARG RS02325
gene id: 1348662:CARG_RS02325
uniprot id: U3GTL1
names: Subcellular Location Annotation
messages: Cell membrane

1348662:CARG RS02835
gene id: 1348662:CARG_RS02835
uniprot id: U3GW99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

1348662:CARG RS08285
gene id: 1348662:CARG_RS08285
uniprot id: U3GWV1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1348662:CARG RS05725
gene id: 1348662:CARG_RS05725
uniprot id: U3GVE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1348662:CARG RS07775
gene id: 1348662:CARG_RS07775
uniprot id: U3GYD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1348662:CARG RS01760
gene id: 1348662:CARG_RS01760
uniprot id: U3GYB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1348662:CARG RS01100
gene id: 1348662:CARG_RS01100
uniprot id: U3GSY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

1348662:CARG RS04785
gene id: 1348662:CARG_RS04785
uniprot id: U3GZB3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1348662:CARG RS02740
gene id: 1348662:CARG_RS02740
uniprot id: U3GTT4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1348662:CARG RS02150
gene id: 1348662:CARG_RS02150
uniprot id: U3GX91
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06505
gene id: 1348662:CARG_RS06505
uniprot id: U3GVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1348662:CARG RS01605
gene id: 1348662:CARG_RS01605
uniprot id: U3GY97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1348662:CARG RS03785
gene id: 1348662:CARG_RS03785
uniprot id: U3GZ28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1348662:CARG RS09175
gene id: 1348662:CARG_RS09175
uniprot id: U3GYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1348662:CARG RS09720
gene id: 1348662:CARG_RS09720
uniprot id: U3GZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1348662:CARG RS08335
gene id: 1348662:CARG_RS08335
uniprot id: U3GWV8
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS08370
gene id: 1348662:CARG_RS08370
uniprot id: U3GZB0
names: Similarity
messages: Belongs to the TPP enzyme family.

1348662:CARG RS00915
gene id: 1348662:CARG_RS00915
uniprot id: U3GSV3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1348662:CARG RS10155
gene id: 1348662:CARG_RS10155
uniprot id: U3GTC9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1348662:CARG RS02850
gene id: 1348662:CARG_RS02850
uniprot id: U3GXI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1348662:CARG RS05675
gene id: 1348662:CARG_RS05675
uniprot id: U3GXT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1348662:CARG RS03410
gene id: 1348662:CARG_RS03410
uniprot id: U3GYY1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1348662:CARG RS01300
gene id: 1348662:CARG_RS01300
uniprot id: U3GY73
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1348662:CARG RS00025
gene id: 1348662:CARG_RS00025
uniprot id: U3GS43
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1348662:CARG RS06380
gene id: 1348662:CARG_RS06380
uniprot id: U3GXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

1348662:CARG RS06500
gene id: 1348662:CARG_RS06500
uniprot id: U3GXX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06285
gene id: 1348662:CARG_RS06285
uniprot id: U3GVQ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1348662:CARG RS08145
gene id: 1348662:CARG_RS08145
uniprot id: U3GZW2
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS01880
gene id: 1348662:CARG_RS01880
uniprot id: U3GSD8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

1348662:CARG RS05100
gene id: 1348662:CARG_RS05100
uniprot id: U3GV41
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1348662:CARG RS00255
gene id: 1348662:CARG_RS00255
uniprot id: U3GUX6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1348662:CARG RS07590
gene id: 1348662:CARG_RS07590
uniprot id: U3GZ61
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1348662:CARG RS04190
gene id: 1348662:CARG_RS04190
uniprot id: U3GU53
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1348662:CARG RS00420
gene id: 1348662:CARG_RS00420
uniprot id: U3GXY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS02015
gene id: 1348662:CARG_RS02015
uniprot id: U3GS15
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1348662:CARG RS05385
gene id: 1348662:CARG_RS05385
uniprot id: U3GV86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

1348662:CARG RS04575
gene id: 1348662:CARG_RS04575
uniprot id: U3GUC7
names: Similarity
messages: Belongs to the CobH/CbiC family.

1348662:CARG RS07630
gene id: 1348662:CARG_RS07630
uniprot id: U3GWJ6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

1348662:CARG RS05555
gene id: 1348662:CARG_RS05555
uniprot id: U3GXM4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1348662:CARG RS02705
gene id: 1348662:CARG_RS02705
uniprot id: U3GS23
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1348662:CARG RS05530
gene id: 1348662:CARG_RS05530
uniprot id: U3GXM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

1348662:CARG RS03635
gene id: 1348662:CARG_RS03635
uniprot id: U3GU84
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS09305
gene id: 1348662:CARG_RS09305
uniprot id: U3GWS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06710
gene id: 1348662:CARG_RS06710
uniprot id: U3GYU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1348662:CARG RS06860
gene id: 1348662:CARG_RS06860
uniprot id: U3GVJ2
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

1348662:CARG RS05595
gene id: 1348662:CARG_RS05595
uniprot id: U3GYG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1348662:CARG RS01370
gene id: 1348662:CARG_RS01370
uniprot id: U3GVG5
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07270
gene id: 1348662:CARG_RS07270
uniprot id: U3GVS4
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07950
gene id: 1348662:CARG_RS07950
uniprot id: U3GZ86
names: Similarity
messages: Belongs to the WXG100 family.

1348662:CARG RS09255
gene id: 1348662:CARG_RS09255
uniprot id: U3GW76
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS00855
gene id: 1348662:CARG_RS00855
uniprot id: U3GWL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. MshA subfamily.
messages: Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
messages: Homodimer.

1348662:CARG RS03480
gene id: 1348662:CARG_RS03480
uniprot id: U3GXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1348662:CARG RS05000
gene id: 1348662:CARG_RS05000
uniprot id: U3GV25
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

1348662:CARG RS05140
gene id: 1348662:CARG_RS05140
uniprot id: U3GZE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1348662:CARG RS06640
gene id: 1348662:CARG_RS06640
uniprot id: U3GYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

1348662:CARG RS07115
gene id: 1348662:CARG_RS07115
uniprot id: U3GZ03
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1348662:CARG RS08645
gene id: 1348662:CARG_RS08645
uniprot id: U3GYN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1348662:CARG RS09415
gene id: 1348662:CARG_RS09415
uniprot id: U3H017
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1348662:CARG RS09625
gene id: 1348662:CARG_RS09625
uniprot id: U3GZ60
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS09115
gene id: 1348662:CARG_RS09115
uniprot id: U3GZG9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

1348662:CARG RS06260
gene id: 1348662:CARG_RS06260
uniprot id: U3GVP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1348662:CARG RS06090
gene id: 1348662:CARG_RS06090
uniprot id: U3GZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1348662:CARG RS07425
gene id: 1348662:CARG_RS07425
uniprot id: U3GVW2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

1348662:CARG RS05600
gene id: 1348662:CARG_RS05600
uniprot id: U3GZH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1348662:CARG RS03000
gene id: 1348662:CARG_RS03000
uniprot id: U3GXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1348662:CARG RS02730
gene id: 1348662:CARG_RS02730
uniprot id: U3GYP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1348662:CARG RS05780
gene id: 1348662:CARG_RS05780
uniprot id: U3GUX3
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06250
gene id: 1348662:CARG_RS06250
uniprot id: U3GZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1348662:CARG RS07000
gene id: 1348662:CARG_RS07000
uniprot id: U3GZR4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1348662:CARG RS08600
gene id: 1348662:CARG_RS08600
uniprot id: U3GX13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1348662:CARG RS05260
gene id: 1348662:CARG_RS05260
uniprot id: U3GYC3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1348662:CARG RS01355
gene id: 1348662:CARG_RS01355
uniprot id: U3GSN8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1348662:CARG RS03885
gene id: 1348662:CARG_RS03885
uniprot id: U3GWU3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1348662:CARG RS03075
gene id: 1348662:CARG_RS03075
uniprot id: U3GXL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

1348662:CARG RS04425
gene id: 1348662:CARG_RS04425
uniprot id: U3GU96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1348662:CARG RS02735
gene id: 1348662:CARG_RS02735
uniprot id: U3GW83
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1348662:CARG RS05465
gene id: 1348662:CARG_RS05465
uniprot id: U3GYE7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS02950
gene id: 1348662:CARG_RS02950
uniprot id: U3GTG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1348662:CARG RS04400
gene id: 1348662:CARG_RS04400
uniprot id: U3GY20
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1348662:CARG RS09230
gene id: 1348662:CARG_RS09230
uniprot id: U3H005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06465
gene id: 1348662:CARG_RS06465
uniprot id: U3GYR8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

1348662:CARG RS04205
gene id: 1348662:CARG_RS04205
uniprot id: U3GX12
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1348662:CARG RS03845
gene id: 1348662:CARG_RS03845
uniprot id: U3GTY1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1348662:CARG RS02880
gene id: 1348662:CARG_RS02880
uniprot id: U3GWA8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1348662:CARG RS02650
gene id: 1348662:CARG_RS02650
uniprot id: U3GUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS07645
gene id: 1348662:CARG_RS07645
uniprot id: U3GZU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06745
gene id: 1348662:CARG_RS06745
uniprot id: U3GY06
names: Similarity
messages: Belongs to the heme oxygenase family.

1348662:CARG RS09250
gene id: 1348662:CARG_RS09250
uniprot id: U3GWR1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1348662:CARG RS01405
gene id: 1348662:CARG_RS01405
uniprot id: U3GWW4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS01075
gene id: 1348662:CARG_RS01075
uniprot id: U3GVC4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1348662:CARG RS02100
gene id: 1348662:CARG_RS02100
uniprot id: U3GT12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1348662:CARG RS06095
gene id: 1348662:CARG_RS06095
uniprot id: U3GXS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03695
gene id: 1348662:CARG_RS03695
uniprot id: U3GTV1
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS01660
gene id: 1348662:CARG_RS01660
uniprot id: U3GVL2
names: Similarity
messages: Belongs to the AccD/PCCB family.

1348662:CARG RS01260
gene id: 1348662:CARG_RS01260
uniprot id: U3GS04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1348662:CARG RS06490
gene id: 1348662:CARG_RS06490
uniprot id: U3GYS2
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06400
gene id: 1348662:CARG_RS06400
uniprot id: U3GZN4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1348662:CARG RS10490
gene id: 1348662:CARG_RS10490
uniprot id: U3GZD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1348662:CARG RS05605
gene id: 1348662:CARG_RS05605
uniprot id: U3GS27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1348662:CARG RS03850
gene id: 1348662:CARG_RS03850
uniprot id: U3GXU7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1348662:CARG RS00985
gene id: 1348662:CARG_RS00985
uniprot id: U3GVA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1348662:CARG RS00515
gene id: 1348662:CARG_RS00515
uniprot id: U3GSA6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07020
gene id: 1348662:CARG_RS07020
uniprot id: U3GYY8
names: Similarity
messages: Belongs to the disproportionating enzyme family.

1348662:CARG RS05805
gene id: 1348662:CARG_RS05805
uniprot id: U3GUX5
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1348662:CARG RS01170
gene id: 1348662:CARG_RS01170
uniprot id: U3GWS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1348662:CARG RS04160
gene id: 1348662:CARG_RS04160
uniprot id: U3GUH6
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05995
gene id: 1348662:CARG_RS05995
uniprot id: U3GZK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1348662:CARG RS08545
gene id: 1348662:CARG_RS08545
uniprot id: U3GZX7
names: Similarity
messages: Belongs to the peptidase S13 family.

1348662:CARG RS02280
gene id: 1348662:CARG_RS02280
uniprot id: U3GT38
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1348662:CARG RS07320
gene id: 1348662:CARG_RS07320
uniprot id: U3GVT4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1348662:CARG RS01740
gene id: 1348662:CARG_RS01740
uniprot id: U3GVM6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1348662:CARG RS02055
gene id: 1348662:CARG_RS02055
uniprot id: U3GX76
names: Similarity
messages: Belongs to the AccD/PCCB family.

1348662:CARG RS02225
gene id: 1348662:CARG_RS02225
uniprot id: U3GTH9
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1348662:CARG RS00465
gene id: 1348662:CARG_RS00465
uniprot id: U3GSA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

1348662:CARG RS08340
gene id: 1348662:CARG_RS08340
uniprot id: U3GW88
names: Similarity
messages: Belongs to the GARS family.

1348662:CARG RS08585
gene id: 1348662:CARG_RS08585
uniprot id: U3GZC5
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

1348662:CARG RS06705
gene id: 1348662:CARG_RS06705
uniprot id: U3GVG2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1348662:CARG RS07295
gene id: 1348662:CARG_RS07295
uniprot id: U3GVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1348662:CARG RS08140
gene id: 1348662:CARG_RS08140
uniprot id: U3GZ96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1348662:CARG RS07790
gene id: 1348662:CARG_RS07790
uniprot id: U3GZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS07865
gene id: 1348662:CARG_RS07865
uniprot id: U3GZ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1348662:CARG RS04460
gene id: 1348662:CARG_RS04460
uniprot id: U3GZ83
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03970
gene id: 1348662:CARG_RS03970
uniprot id: U3GUF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS04690
gene id: 1348662:CARG_RS04690
uniprot id: U3GX97
names: Similarity
messages: Belongs to the peptidase M18 family.

1348662:CARG RS02985
gene id: 1348662:CARG_RS02985
uniprot id: U3GYT2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1348662:CARG RS07840
gene id: 1348662:CARG_RS07840
uniprot id: U3GZ79
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1348662:CARG RS00135
gene id: 1348662:CARG_RS00135
uniprot id: U3GS59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

1348662:CARG RS01765
gene id: 1348662:CARG_RS01765
uniprot id: U3GVN1
names: Similarity
messages: Belongs to the thymidylate kinase family.

1348662:CARG RS05650
gene id: 1348662:CARG_RS05650
uniprot id: U3GYG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1348662:CARG RS00815
gene id: 1348662:CARG_RS00815
uniprot id: U3GV67
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1348662:CARG RS01935
gene id: 1348662:CARG_RS01935
uniprot id: U3GX59
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1348662:CARG RS03895
gene id: 1348662:CARG_RS03895
uniprot id: U3GXV3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1348662:CARG RS02310
gene id: 1348662:CARG_RS02310
uniprot id: U3GXC1
names: Similarity
messages: Belongs to the AccD/PCCB family.

1348662:CARG RS01225
gene id: 1348662:CARG_RS01225
uniprot id: U3GY67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1348662:CARG RS09365
gene id: 1348662:CARG_RS09365
uniprot id: U3H015
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1348662:CARG RS01800
gene id: 1348662:CARG_RS01800
uniprot id: U3GSW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

1348662:CARG RS09165
gene id: 1348662:CARG_RS09165
uniprot id: U3GZH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1348662:CARG RS00820
gene id: 1348662:CARG_RS00820
uniprot id: U3GST7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1348662:CARG RS06530
gene id: 1348662:CARG_RS06530
uniprot id: U3GVU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1348662:CARG RS03355
gene id: 1348662:CARG_RS03355
uniprot id: U3GW58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06825
gene id: 1348662:CARG_RS06825
uniprot id: U3GVZ9
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

1348662:CARG RS05280
gene id: 1348662:CARG_RS05280
uniprot id: U3GUP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1348662:CARG RS06830
gene id: 1348662:CARG_RS06830
uniprot id: U3GVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

1348662:CARG RS03025
gene id: 1348662:CARG_RS03025
uniprot id: U3GXK9
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07755
gene id: 1348662:CARG_RS07755
uniprot id: U3GWM0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

1348662:CARG RS01775
gene id: 1348662:CARG_RS01775
uniprot id: U3GSV8
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1348662:CARG RS06340
gene id: 1348662:CARG_RS06340
uniprot id: U3GVR1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1348662:CARG RS08290
gene id: 1348662:CARG_RS08290
uniprot id: U3GW79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1348662:CARG RS09335
gene id: 1348662:CARG_RS09335
uniprot id: U3GZI7
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS08215
gene id: 1348662:CARG_RS08215
uniprot id: U3GZW4
names: Similarity
messages: Belongs to the histone deacetylase family.

1348662:CARG RS00415
gene id: 1348662:CARG_RS00415
uniprot id: U3GWD5
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS00910
gene id: 1348662:CARG_RS00910
uniprot id: U3GV88
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

1348662:CARG RS04250
gene id: 1348662:CARG_RS04250
uniprot id: U3GZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1348662:CARG RS01440
gene id: 1348662:CARG_RS01440
uniprot id: U3GVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1348662:CARG RS00280
gene id: 1348662:CARG_RS00280
uniprot id: U3GUX9
names: Similarity
messages: Belongs to the peptidase M13 family.

1348662:CARG RS07480
gene id: 1348662:CARG_RS07480
uniprot id: U3GZ54
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

1348662:CARG RS07640
gene id: 1348662:CARG_RS07640
uniprot id: U3GZ65
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS09370
gene id: 1348662:CARG_RS09370
uniprot id: U3GYW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1348662:CARG RS08320
gene id: 1348662:CARG_RS08320
uniprot id: U3GZA7
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

1348662:CARG RS08550
gene id: 1348662:CARG_RS08550
uniprot id: U3GYL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1348662:CARG RS05820
gene id: 1348662:CARG_RS05820
uniprot id: U3GXP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03120
gene id: 1348662:CARG_RS03120
uniprot id: U3GTJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LigB/MhpB extradiol dioxygenase family.
messages: Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
messages: Homotetramer.

1348662:CARG RS05275
gene id: 1348662:CARG_RS05275
uniprot id: U3GV72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1348662:CARG RS05750
gene id: 1348662:CARG_RS05750
uniprot id: U3GVF0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1348662:CARG RS04980
gene id: 1348662:CARG_RS04980
uniprot id: U3GUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

1348662:CARG RS01465
gene id: 1348662:CARG_RS01465
uniprot id: U3GSQ2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

1348662:CARG RS03335
gene id: 1348662:CARG_RS03335
uniprot id: U3GYX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

1348662:CARG RS06960
gene id: 1348662:CARG_RS06960
uniprot id: U3GVL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1348662:CARG RS09420
gene id: 1348662:CARG_RS09420
uniprot id: U3GYX1
names: Similarity
messages: Belongs to the thioredoxin family.

1348662:CARG RS03590
gene id: 1348662:CARG_RS03590
uniprot id: U3GU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1348662:CARG RS02810
gene id: 1348662:CARG_RS02810
uniprot id: U3GW95
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03180
gene id: 1348662:CARG_RS03180
uniprot id: U3GYV6
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05635
gene id: 1348662:CARG_RS05635
uniprot id: U3GXN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

1348662:CARG RS00885
gene id: 1348662:CARG_RS00885
uniprot id: U3GY32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1348662:CARG RS02475
gene id: 1348662:CARG_RS02475
uniprot id: U3GSE2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1348662:CARG RS02105
gene id: 1348662:CARG_RS02105
uniprot id: U3GX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1348662:CARG RS02295
gene id: 1348662:CARG_RS02295
uniprot id: U3GVX5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

1348662:CARG RS04640
gene id: 1348662:CARG_RS04640
uniprot id: U3GX88
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

1348662:CARG RS01125
gene id: 1348662:CARG_RS01125
uniprot id: U3GY56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1348662:CARG RS06720
gene id: 1348662:CARG_RS06720
uniprot id: U3GY04
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS00430
gene id: 1348662:CARG_RS00430
uniprot id: U3GSM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1348662:CARG RS01430
gene id: 1348662:CARG_RS01430
uniprot id: U3GWW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1348662:CARG RS08735
gene id: 1348662:CARG_RS08735
uniprot id: U3GWF7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1348662:CARG RS03540
gene id: 1348662:CARG_RS03540
uniprot id: U3GWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS05500
gene id: 1348662:CARG_RS05500
uniprot id: U3GXL9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1348662:CARG RS06395
gene id: 1348662:CARG_RS06395
uniprot id: U3GYR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

1348662:CARG RS03460
gene id: 1348662:CARG_RS03460
uniprot id: U3GYY6
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1348662:CARG RS04950
gene id: 1348662:CARG_RS04950
uniprot id: U3GUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1348662:CARG RS06060
gene id: 1348662:CARG_RS06060
uniprot id: U3GYL1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

1348662:CARG RS07260
gene id: 1348662:CARG_RS07260
uniprot id: U3GY66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1348662:CARG RS05015
gene id: 1348662:CARG_RS05015
uniprot id: U3GZD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1348662:CARG RS07975
gene id: 1348662:CARG_RS07975
uniprot id: U3GZ88
names: Similarity
messages: Belongs to the peptidase S8 family.

1348662:CARG RS09465
gene id: 1348662:CARG_RS09465
uniprot id: U3GSI0
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS09455
gene id: 1348662:CARG_RS09455
uniprot id: U3GWV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1348662:CARG RS06270
gene id: 1348662:CARG_RS06270
uniprot id: U3GYP3
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS04955
gene id: 1348662:CARG_RS04955
uniprot id: U3GUS4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS04890
gene id: 1348662:CARG_RS04890
uniprot id: U3GXE1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

1348662:CARG RS09300
gene id: 1348662:CARG_RS09300
uniprot id: U3GXB5
names: Similarity
messages: Belongs to the FPG family.

1348662:CARG RS08860
gene id: 1348662:CARG_RS08860
uniprot id: U3GX53
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06685
gene id: 1348662:CARG_RS06685
uniprot id: U3GYU6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1348662:CARG RS05865
gene id: 1348662:CARG_RS05865
uniprot id: U3GZJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1348662:CARG RS00905
gene id: 1348662:CARG_RS00905
uniprot id: U3GY35
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1348662:CARG RS03265
gene id: 1348662:CARG_RS03265
uniprot id: U3GWG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1348662:CARG RS02795
gene id: 1348662:CARG_RS02795
uniprot id: U3GTE1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1348662:CARG RS08070
gene id: 1348662:CARG_RS08070
uniprot id: U3GZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS07925
gene id: 1348662:CARG_RS07925
uniprot id: U3GYE9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1348662:CARG RS06990
gene id: 1348662:CARG_RS06990
uniprot id: U3GVL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

1348662:CARG RS05490
gene id: 1348662:CARG_RS05490
uniprot id: U3GYF0
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

1348662:CARG RS00510
gene id: 1348662:CARG_RS00510
uniprot id: U3GSN7
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

1348662:CARG RS04755
gene id: 1348662:CARG_RS04755
uniprot id: U3GZB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1348662:CARG RS01400
gene id: 1348662:CARG_RS01400
uniprot id: U3GUQ9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1348662:CARG RS03905
gene id: 1348662:CARG_RS03905
uniprot id: U3GWV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07660
gene id: 1348662:CARG_RS07660
uniprot id: U3GVZ1
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1348662:CARG RS07080
gene id: 1348662:CARG_RS07080
uniprot id: U3GY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS08235
gene id: 1348662:CARG_RS08235
uniprot id: U3GZA1
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

1348662:CARG RS00530
gene id: 1348662:CARG_RS00530
uniprot id: U3GV17
names: Similarity
messages: Belongs to the catalase family.

1348662:CARG RS01250
gene id: 1348662:CARG_RS01250
uniprot id: U3GWU2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1348662:CARG RS04000
gene id: 1348662:CARG_RS04000
uniprot id: U3GU17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1348662:CARG RS07400
gene id: 1348662:CARG_RS07400
uniprot id: U3GZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1348662:CARG RS09180
gene id: 1348662:CARG_RS09180
uniprot id: U3GX99
names: Similarity
messages: Belongs to the universal stress protein A family.

1348662:CARG RS04265
gene id: 1348662:CARG_RS04265
uniprot id: U3GU68
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS09360
gene id: 1348662:CARG_RS09360
uniprot id: U3GZI9
names: Function
names: Similarity
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

1348662:CARG RS01630
gene id: 1348662:CARG_RS01630
uniprot id: U3GYA0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1348662:CARG RS08060
gene id: 1348662:CARG_RS08060
uniprot id: U3GWS0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

1348662:CARG RS03935
gene id: 1348662:CARG_RS03935
uniprot id: U3GU03
names: Similarity
messages: Belongs to the CsoR family.

1348662:CARG RS07740
gene id: 1348662:CARG_RS07740
uniprot id: U3GZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06625
gene id: 1348662:CARG_RS06625
uniprot id: U3GXZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

1348662:CARG RS05535
gene id: 1348662:CARG_RS05535
uniprot id: U3GVB3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1348662:CARG RS01865
gene id: 1348662:CARG_RS01865
uniprot id: U3GVQ0
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

1348662:CARG RS02075
gene id: 1348662:CARG_RS02075
uniprot id: U3GT08
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1348662:CARG RS05455
gene id: 1348662:CARG_RS05455
uniprot id: U3GVA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS08040
gene id: 1348662:CARG_RS08040
uniprot id: U3GZ91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1348662:CARG RS02685
gene id: 1348662:CARG_RS02685
uniprot id: U3GTC4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1348662:CARG RS10485
gene id: 1348662:CARG_RS10485
uniprot id: U3GY93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1348662:CARG RS04610
gene id: 1348662:CARG_RS04610
uniprot id: U3GZ97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1348662:CARG RS06750
gene id: 1348662:CARG_RS06750
uniprot id: U3GVY7
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

1348662:CARG RS05080
gene id: 1348662:CARG_RS05080
uniprot id: U3GUM1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1348662:CARG RS01105
gene id: 1348662:CARG_RS01105
uniprot id: U3GSK1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1348662:CARG RS04365
gene id: 1348662:CARG_RS04365
uniprot id: U3GUL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

1348662:CARG RS09570
gene id: 1348662:CARG_RS09570
uniprot id: U3GW92
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

1348662:CARG RS07380
gene id: 1348662:CARG_RS07380
uniprot id: U3GY81
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1348662:CARG RS04390
gene id: 1348662:CARG_RS04390
uniprot id: U3GUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS04685
gene id: 1348662:CARG_RS04685
uniprot id: U3GZA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

1348662:CARG RS01510
gene id: 1348662:CARG_RS01510
uniprot id: U3GT36
names: Similarity
messages: Belongs to the peptidase S58 family.

1348662:CARG RS08675
gene id: 1348662:CARG_RS08675
uniprot id: U3GX25
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1348662:CARG RS00930
gene id: 1348662:CARG_RS00930
uniprot id: U3GY38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS02240
gene id: 1348662:CARG_RS02240
uniprot id: U3GYH4
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1348662:CARG RS00300
gene id: 1348662:CARG_RS00300
uniprot id: U3GXX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS07940
gene id: 1348662:CARG_RS07940
uniprot id: U3GS30
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1348662:CARG RS08955
gene id: 1348662:CARG_RS08955
uniprot id: U3GX68
names: Similarity
messages: Belongs to the AccD/PCCB family.

1348662:CARG RS02975
gene id: 1348662:CARG_RS02975
uniprot id: U3GTH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07135
gene id: 1348662:CARG_RS07135
uniprot id: U3GVP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

1348662:CARG RS02895
gene id: 1348662:CARG_RS02895
uniprot id: U3GXJ4
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03425
gene id: 1348662:CARG_RS03425
uniprot id: U3GTP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1348662:CARG RS07610
gene id: 1348662:CARG_RS07610
uniprot id: U3GVY5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1348662:CARG RS04150
gene id: 1348662:CARG_RS04150
uniprot id: U3GZ55
names: Similarity
messages: Belongs to the universal stress protein A family.

1348662:CARG RS01745
gene id: 1348662:CARG_RS01745
uniprot id: U3GT71
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

1348662:CARG RS05970
gene id: 1348662:CARG_RS05970
uniprot id: U3GZK2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1348662:CARG RS07395
gene id: 1348662:CARG_RS07395
uniprot id: U3GZ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1348662:CARG RS05085
gene id: 1348662:CARG_RS05085
uniprot id: U3GYA2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS09090
gene id: 1348662:CARG_RS09090
uniprot id: U3GZG7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

1348662:CARG RS01190
gene id: 1348662:CARG_RS01190
uniprot id: U3GXR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1348662:CARG RS08110
gene id: 1348662:CARG_RS08110
uniprot id: U3GZ94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03655
gene id: 1348662:CARG_RS03655
uniprot id: U3GWP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1348662:CARG RS06595
gene id: 1348662:CARG_RS06595
uniprot id: U3GZP2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

1348662:CARG RS08195
gene id: 1348662:CARG_RS08195
uniprot id: U3GYH2
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1348662:CARG RS03795
gene id: 1348662:CARG_RS03795
uniprot id: U3GUB2
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1348662:CARG RS05195
gene id: 1348662:CARG_RS05195
uniprot id: U3GXI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS06810
gene id: 1348662:CARG_RS06810
uniprot id: U3GYW3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1348662:CARG RS05090
gene id: 1348662:CARG_RS05090
uniprot id: U3GZE4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1348662:CARG RS08485
gene id: 1348662:CARG_RS08485
uniprot id: U3GZB9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS01645
gene id: 1348662:CARG_RS01645
uniprot id: U3GST4
names: Similarity
messages: Belongs to the AccD/PCCB family.

1348662:CARG RS03880
gene id: 1348662:CARG_RS03880
uniprot id: U3GZ37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07200
gene id: 1348662:CARG_RS07200
uniprot id: U3GZS6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1348662:CARG RS00305
gene id: 1348662:CARG_RS00305
uniprot id: U3GUY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06820
gene id: 1348662:CARG_RS06820
uniprot id: U3GY16
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS04080
gene id: 1348662:CARG_RS04080
uniprot id: U3GUG4
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

1348662:CARG RS04615
gene id: 1348662:CARG_RS04615
uniprot id: U3GX84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1348662:CARG RS05930
gene id: 1348662:CARG_RS05930
uniprot id: U3GVI4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1348662:CARG RS01115
gene id: 1348662:CARG_RS01115
uniprot id: U3GRZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1348662:CARG RS04820
gene id: 1348662:CARG_RS04820
uniprot id: U3GUW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03140
gene id: 1348662:CARG_RS03140
uniprot id: U3GTZ9
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

1348662:CARG RS04975
gene id: 1348662:CARG_RS04975
uniprot id: U3GV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

1348662:CARG RS08570
gene id: 1348662:CARG_RS08570
uniprot id: U3GZC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1348662:CARG RS09120
gene id: 1348662:CARG_RS09120
uniprot id: U3H001
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05940
gene id: 1348662:CARG_RS05940
uniprot id: U3GYJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1348662:CARG RS03615
gene id: 1348662:CARG_RS03615
uniprot id: U3GU80
names: Similarity
messages: Belongs to the LOG family.

1348662:CARG RS07195
gene id: 1348662:CARG_RS07195
uniprot id: U3GZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS05855
gene id: 1348662:CARG_RS05855
uniprot id: U3GUY1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

1348662:CARG RS07450
gene id: 1348662:CARG_RS07450
uniprot id: U3GVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS01410
gene id: 1348662:CARG_RS01410
uniprot id: U3GSD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS00450
gene id: 1348662:CARG_RS00450
uniprot id: U3GXY5
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

1348662:CARG RS04140
gene id: 1348662:CARG_RS04140
uniprot id: U3GU44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1348662:CARG RS03930
gene id: 1348662:CARG_RS03930
uniprot id: U3GUE0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06195
gene id: 1348662:CARG_RS06195
uniprot id: U3GYN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

1348662:CARG RS03525
gene id: 1348662:CARG_RS03525
uniprot id: U3GTR8
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS00470
gene id: 1348662:CARG_RS00470
uniprot id: U3GWE4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

1348662:CARG RS03135
gene id: 1348662:CARG_RS03135
uniprot id: U3GWE5
names: Similarity
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

1348662:CARG RS05075
gene id: 1348662:CARG_RS05075
uniprot id: U3GV37
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03625
gene id: 1348662:CARG_RS03625
uniprot id: U3GZ09
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

1348662:CARG RS00715
gene id: 1348662:CARG_RS00715
uniprot id: U3GSR9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1348662:CARG RS08685
gene id: 1348662:CARG_RS08685
uniprot id: U3GZD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1348662:CARG RS04235
gene id: 1348662:CARG_RS04235
uniprot id: U3GUI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1348662:CARG RS07190
gene id: 1348662:CARG_RS07190
uniprot id: U3GVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS03285
gene id: 1348662:CARG_RS03285
uniprot id: U3GWH2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1348662:CARG RS07005
gene id: 1348662:CARG_RS07005
uniprot id: U3GY37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1348662:CARG RS03455
gene id: 1348662:CARG_RS03455
uniprot id: U3GXP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1348662:CARG RS05035
gene id: 1348662:CARG_RS05035
uniprot id: U3GY96
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

1348662:CARG RS06630
gene id: 1348662:CARG_RS06630
uniprot id: U3GVW8
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

1348662:CARG RS04835
gene id: 1348662:CARG_RS04835
uniprot id: U3GZB7
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1348662:CARG RS06235
gene id: 1348662:CARG_RS06235
uniprot id: U3GVP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1348662:CARG RS08500
gene id: 1348662:CARG_RS08500
uniprot id: U3GWZ1
names: Similarity
messages: Belongs to the pantothenate synthetase family.

1348662:CARG RS01390
gene id: 1348662:CARG_RS01390
uniprot id: U3GW39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1348662:CARG RS09430
gene id: 1348662:CARG_RS09430
uniprot id: U3GWU9
names: Similarity
messages: Belongs to the ParB family.

1348662:CARG RS03065
gene id: 1348662:CARG_RS03065
uniprot id: U3GTY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

1348662:CARG RS06610
gene id: 1348662:CARG_RS06610
uniprot id: U3GVE4
names: Similarity
messages: Belongs to the peptidase C40 family.

1348662:CARG RS02010
gene id: 1348662:CARG_RS02010
uniprot id: U3GSZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1348662:CARG RS04110
gene id: 1348662:CARG_RS04110
uniprot id: U3GU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS08125
gene id: 1348662:CARG_RS08125
uniprot id: U3GWT0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1348662:CARG RS08135
gene id: 1348662:CARG_RS08135
uniprot id: U3GW57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1348662:CARG RS06450
gene id: 1348662:CARG_RS06450
uniprot id: U3GXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

1348662:CARG RS04545
gene id: 1348662:CARG_RS04545
uniprot id: U3GUQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS04290
gene id: 1348662:CARG_RS04290
uniprot id: U3GU73
names: Similarity
messages: Belongs to the UPF0434 family.

1348662:CARG RS01275
gene id: 1348662:CARG_RS01275
uniprot id: U3GXR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1348662:CARG RS09445
gene id: 1348662:CARG_RS09445
uniprot id: U3GYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

1348662:CARG RS06725
gene id: 1348662:CARG_RS06725
uniprot id: U3GVY3
names: Similarity
messages: Belongs to the glutamine synthetase family.

1348662:CARG RS00340
gene id: 1348662:CARG_RS00340
uniprot id: U3GWC5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1348662:CARG RS06575
gene id: 1348662:CARG_RS06575
uniprot id: U3GXY6
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

1348662:CARG RS04050
gene id: 1348662:CARG_RS04050
uniprot id: U3GWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1348662:CARG RS05460
gene id: 1348662:CARG_RS05460
uniprot id: U3GUS3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1348662:CARG RS04185
gene id: 1348662:CARG_RS04185
uniprot id: U3GUI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

1348662:CARG RS06485
gene id: 1348662:CARG_RS06485
uniprot id: U3GVB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS01255
gene id: 1348662:CARG_RS01255
uniprot id: U3GSD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1348662:CARG RS07680
gene id: 1348662:CARG_RS07680
uniprot id: U3GWK6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1348662:CARG RS02725
gene id: 1348662:CARG_RS02725
uniprot id: U3GXH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1348662:CARG RS07310
gene id: 1348662:CARG_RS07310
uniprot id: U3GY72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1348662:CARG RS09440
gene id: 1348662:CARG_RS09440
uniprot id: U3H019
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

1348662:CARG RS07860
gene id: 1348662:CARG_RS07860
uniprot id: U3GW15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

1348662:CARG RS04665
gene id: 1348662:CARG_RS04665
uniprot id: U3GX93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1348662:CARG RS07350
gene id: 1348662:CARG_RS07350
uniprot id: U3GZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS04455
gene id: 1348662:CARG_RS04455
uniprot id: U3GY26
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS08725
gene id: 1348662:CARG_RS08725
uniprot id: U3GYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1348662:CARG RS01065
gene id: 1348662:CARG_RS01065
uniprot id: U3GWR2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

1348662:CARG RS08115
gene id: 1348662:CARG_RS08115
uniprot id: U3GZW1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1348662:CARG RS06670
gene id: 1348662:CARG_RS06670
uniprot id: U3GXZ8
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

1348662:CARG RS08610
gene id: 1348662:CARG_RS08610
uniprot id: U3GZC7
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1348662:CARG RS01810
gene id: 1348662:CARG_RS01810
uniprot id: U3GYC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

1348662:CARG RS01185
gene id: 1348662:CARG_RS01185
uniprot id: U3GW30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1348662:CARG RS04095
gene id: 1348662:CARG_RS04095
uniprot id: U3GZ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1348662:CARG RS06510
gene id: 1348662:CARG_RS06510
uniprot id: U3GVC1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06070
gene id: 1348662:CARG_RS06070
uniprot id: U3GXS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1348662:CARG RS08405
gene id: 1348662:CARG_RS08405
uniprot id: U3GZX1
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1348662:CARG RS09410
gene id: 1348662:CARG_RS09410
uniprot id: U3GZJ4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1348662:CARG RS00225
gene id: 1348662:CARG_RS00225
uniprot id: U3GXW4
names: Similarity
messages: Belongs to the UPF0145 family.

1348662:CARG RS01195
gene id: 1348662:CARG_RS01195
uniprot id: U3GWT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1348662:CARG RS08525
gene id: 1348662:CARG_RS08525
uniprot id: U3GUT8
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

1348662:CARG RS02900
gene id: 1348662:CARG_RS02900
uniprot id: U3GYS5
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

1348662:CARG RS04735
gene id: 1348662:CARG_RS04735
uniprot id: U3GXA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

1348662:CARG RS00965
gene id: 1348662:CARG_RS00965
uniprot id: U3GSW3
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07715
gene id: 1348662:CARG_RS07715
uniprot id: U3GZ70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1348662:CARG RS04510
gene id: 1348662:CARG_RS04510
uniprot id: U3GZ87
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

1348662:CARG RS08770
gene id: 1348662:CARG_RS08770
uniprot id: U3GYP6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1348662:CARG RS00660
gene id: 1348662:CARG_RS00660
uniprot id: U3GV39
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS04170
gene id: 1348662:CARG_RS04170
uniprot id: U3GXZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1348662:CARG RS07955
gene id: 1348662:CARG_RS07955
uniprot id: U3GZV6
names: Similarity
messages: Belongs to the WXG100 family.

1348662:CARG RS05870
gene id: 1348662:CARG_RS05870
uniprot id: U3GXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1348662:CARG RS07735
gene id: 1348662:CARG_RS07735
uniprot id: U3GW01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS09225
gene id: 1348662:CARG_RS09225
uniprot id: U3GZH8
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07995
gene id: 1348662:CARG_RS07995
uniprot id: U3GW37
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1348662:CARG RS05145
gene id: 1348662:CARG_RS05145
uniprot id: U3GXH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03535
gene id: 1348662:CARG_RS03535
uniprot id: U3GYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS05840
gene id: 1348662:CARG_RS05840
uniprot id: U3GZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

1348662:CARG RS03800
gene id: 1348662:CARG_RS03800
uniprot id: U3GTX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

1348662:CARG RS01360
gene id: 1348662:CARG_RS01360
uniprot id: U3GWV9
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06230
gene id: 1348662:CARG_RS06230
uniprot id: U3GXU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1348662:CARG RS06160
gene id: 1348662:CARG_RS06160
uniprot id: U3GXT3
names: Similarity
messages: Belongs to the HSP15 family.

1348662:CARG RS04790
gene id: 1348662:CARG_RS04790
uniprot id: U3GXB3
names: Subunit
messages: Heterodimer of an alpha and a beta chain.

1348662:CARG RS07160
gene id: 1348662:CARG_RS07160
uniprot id: U3GW65
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS00460
gene id: 1348662:CARG_RS00460
uniprot id: U3GSM9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1348662:CARG RS08940
gene id: 1348662:CARG_RS08940
uniprot id: U3GWJ9
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS04145
gene id: 1348662:CARG_RS04145
uniprot id: U3GXY7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1348662:CARG RS07220
gene id: 1348662:CARG_RS07220
uniprot id: U3GZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1348662:CARG RS05250
gene id: 1348662:CARG_RS05250
uniprot id: U3GV70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

1348662:CARG RS00195
gene id: 1348662:CARG_RS00195
uniprot id: U3GWA3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1348662:CARG RS06290
gene id: 1348662:CARG_RS06290
uniprot id: U3GV73
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS07265
gene id: 1348662:CARG_RS07265
uniprot id: U3GW90
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

1348662:CARG RS00010
gene id: 1348662:CARG_RS00010
uniprot id: U3GXU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1348662:CARG RS08710
gene id: 1348662:CARG_RS08710
uniprot id: U3GSG0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS04740
gene id: 1348662:CARG_RS04740
uniprot id: U3GUU8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06175
gene id: 1348662:CARG_RS06175
uniprot id: U3GZL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1348662:CARG RS08765
gene id: 1348662:CARG_RS08765
uniprot id: U3GZY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1348662:CARG RS00215
gene id: 1348662:CARG_RS00215
uniprot id: U3GS71
names: Similarity
messages: Belongs to the HIBADH-related family.

1348662:CARG RS01395
gene id: 1348662:CARG_RS01395
uniprot id: U3GXS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1348662:CARG RS06210
gene id: 1348662:CARG_RS06210
uniprot id: U3GVN9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1348662:CARG RS08270
gene id: 1348662:CARG_RS08270
uniprot id: U3GZW6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

1348662:CARG RS05810
gene id: 1348662:CARG_RS05810
uniprot id: U3GYI4
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06320
gene id: 1348662:CARG_RS06320
uniprot id: U3GYQ0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1348662:CARG RS05735
gene id: 1348662:CARG_RS05735
uniprot id: U3GYH7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS04240
gene id: 1348662:CARG_RS04240
uniprot id: U3GU63
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1348662:CARG RS05325
gene id: 1348662:CARG_RS05325
uniprot id: U3GV82
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

1348662:CARG RS00455
gene id: 1348662:CARG_RS00455
uniprot id: U3GV01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

1348662:CARG RS03435
gene id: 1348662:CARG_RS03435
uniprot id: U3GYY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1348662:CARG RS01130
gene id: 1348662:CARG_RS01130
uniprot id: U3GVC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1348662:CARG RS00480
gene id: 1348662:CARG_RS00480
uniprot id: U3GV06
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

1348662:CARG RS05880
gene id: 1348662:CARG_RS05880
uniprot id: U3GUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1348662:CARG RS01460
gene id: 1348662:CARG_RS01460
uniprot id: U3GT31
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1348662:CARG RS08065
gene id: 1348662:CARG_RS08065
uniprot id: U3GW47
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1348662:CARG RS04215
gene id: 1348662:CARG_RS04215
uniprot id: U3GU57
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1348662:CARG RS05885
gene id: 1348662:CARG_RS05885
uniprot id: U3GUS8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1348662:CARG RS04555
gene id: 1348662:CARG_RS04555
uniprot id: U3GY41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06125
gene id: 1348662:CARG_RS06125
uniprot id: U3GV36
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS09050
gene id: 1348662:CARG_RS09050
uniprot id: U3GYT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1348662:CARG RS04860
gene id: 1348662:CARG_RS04860
uniprot id: U3GXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1348662:CARG RS04340
gene id: 1348662:CARG_RS04340
uniprot id: U3GUK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS01110
gene id: 1348662:CARG_RS01110
uniprot id: U3GSC5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1348662:CARG RS03195
gene id: 1348662:CARG_RS03195
uniprot id: U3GTL0
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

1348662:CARG RS05945
gene id: 1348662:CARG_RS05945
uniprot id: U3GZK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

1348662:CARG RS08760
gene id: 1348662:CARG_RS08760
uniprot id: U3GZD8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1348662:CARG RS06165
gene id: 1348662:CARG_RS06165
uniprot id: U3GV46
names: Similarity
messages: Belongs to the IMPACT family.

1348662:CARG RS02915
gene id: 1348662:CARG_RS02915
uniprot id: U3GTG4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.

1348662:CARG RS07900
gene id: 1348662:CARG_RS07900
uniprot id: U3GYE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS02750
gene id: 1348662:CARG_RS02750
uniprot id: U3GXH4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1348662:CARG RS01150
gene id: 1348662:CARG_RS01150
uniprot id: U3GY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS00680
gene id: 1348662:CARG_RS00680
uniprot id: U3GUP6
names: Subcellular Location Annotation
messages: Cytoplasm

1348662:CARG RS03900
gene id: 1348662:CARG_RS03900
uniprot id: U3GZ40
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS08255
gene id: 1348662:CARG_RS08255
uniprot id: U3GW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1348662:CARG RS08000
gene id: 1348662:CARG_RS08000
uniprot id: U3GZ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

1348662:CARG RS03200
gene id: 1348662:CARG_RS03200
uniprot id: U3GXM7
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

1348662:CARG RS00155
gene id: 1348662:CARG_RS00155
uniprot id: U3GSI4
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03345
gene id: 1348662:CARG_RS03345
uniprot id: U3GU32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06310
gene id: 1348662:CARG_RS06310
uniprot id: U3GVQ6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

1348662:CARG RS04210
gene id: 1348662:CARG_RS04210
uniprot id: U3GUI6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1348662:CARG RS01240
gene id: 1348662:CARG_RS01240
uniprot id: U3GT06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1348662:CARG RS05920
gene id: 1348662:CARG_RS05920
uniprot id: U3GZJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1348662:CARG RS08315
gene id: 1348662:CARG_RS08315
uniprot id: U3GW85
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03220
gene id: 1348662:CARG_RS03220
uniprot id: U3GTL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1348662:CARG RS08150
gene id: 1348662:CARG_RS08150
uniprot id: U3GYG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1348662:CARG RS04045
gene id: 1348662:CARG_RS04045
uniprot id: U3GZ48
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1348662:CARG RS01270
gene id: 1348662:CARG_RS01270
uniprot id: U3GY70
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1348662:CARG RS06245
gene id: 1348662:CARG_RS06245
uniprot id: U3GYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1348662:CARG RS06840
gene id: 1348662:CARG_RS06840
uniprot id: U3GZQ6
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

1348662:CARG RS06805
gene id: 1348662:CARG_RS06805
uniprot id: U3GVI2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1348662:CARG RS00395
gene id: 1348662:CARG_RS00395
uniprot id: U3GS94
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

1348662:CARG RS06700
gene id: 1348662:CARG_RS06700
uniprot id: U3GVY0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1348662:CARG RS03950
gene id: 1348662:CARG_RS03950
uniprot id: U3GU07
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

1348662:CARG RS05040
gene id: 1348662:CARG_RS05040
uniprot id: U3GZD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

1348662:CARG RS07285
gene id: 1348662:CARG_RS07285
uniprot id: U3GY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1348662:CARG RS01445
gene id: 1348662:CARG_RS01445
uniprot id: U3GS11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1348662:CARG RS07780
gene id: 1348662:CARG_RS07780
uniprot id: U3GWM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

1348662:CARG RS07830
gene id: 1348662:CARG_RS07830
uniprot id: U3GWN4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1348662:CARG RS05670
gene id: 1348662:CARG_RS05670
uniprot id: U3GVD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1348662:CARG RS04895
gene id: 1348662:CARG_RS04895
uniprot id: U3GV03
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1348662:CARG RS08025
gene id: 1348662:CARG_RS08025
uniprot id: U3GWR5
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

1348662:CARG RS09315
gene id: 1348662:CARG_RS09315
uniprot id: U3H011
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06225
gene id: 1348662:CARG_RS06225
uniprot id: U3GZM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1348662:CARG RS01385
gene id: 1348662:CARG_RS01385
uniprot id: U3GS07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1348662:CARG RS04035
gene id: 1348662:CARG_RS04035
uniprot id: U3GU23
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1348662:CARG RS04725
gene id: 1348662:CARG_RS04725
uniprot id: U3GY64
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1348662:CARG RS03660
gene id: 1348662:CARG_RS03660
uniprot id: U3GU89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1348662:CARG RS01570
gene id: 1348662:CARG_RS01570
uniprot id: U3GY94
names: Similarity
messages: Belongs to the UPF0371 family.

1348662:CARG RS00935
gene id: 1348662:CARG_RS00935
uniprot id: U3GV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

1348662:CARG RS05925
gene id: 1348662:CARG_RS05925
uniprot id: U3GXQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1348662:CARG RS09310
gene id: 1348662:CARG_RS09310
uniprot id: U3GZI5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

1348662:CARG RS03925
gene id: 1348662:CARG_RS03925
uniprot id: U3GWV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1348662:CARG RS06920
gene id: 1348662:CARG_RS06920
uniprot id: U3GZR0
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

1348662:CARG RS05060
gene id: 1348662:CARG_RS05060
uniprot id: U3GY99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1348662:CARG RS05470
gene id: 1348662:CARG_RS05470
uniprot id: U3GZG8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1348662:CARG RS07455
gene id: 1348662:CARG_RS07455
uniprot id: U3GZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS06650
gene id: 1348662:CARG_RS06650
uniprot id: U3GXZ5
names: Similarity
messages: Belongs to the asparagine synthetase family.

1348662:CARG RS05400
gene id: 1348662:CARG_RS05400
uniprot id: U3GXK8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1348662:CARG RS04135
gene id: 1348662:CARG_RS04135
uniprot id: U3GUH0
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS00525
gene id: 1348662:CARG_RS00525
uniprot id: U3GXZ4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1348662:CARG RS06955
gene id: 1348662:CARG_RS06955
uniprot id: U3GW18
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS07825
gene id: 1348662:CARG_RS07825
uniprot id: U3GYD8
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05105
gene id: 1348662:CARG_RS05105
uniprot id: U3GUM5
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

1348662:CARG RS05685
gene id: 1348662:CARG_RS05685
uniprot id: U3GYH1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1348662:CARG RS01450
gene id: 1348662:CARG_RS01450
uniprot id: U3GW44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1348662:CARG RS02775
gene id: 1348662:CARG_RS02775
uniprot id: U3GXH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

1348662:CARG RS01680
gene id: 1348662:CARG_RS01680
uniprot id: U3GYA7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1348662:CARG RS00795
gene id: 1348662:CARG_RS00795
uniprot id: U3GST2
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

1348662:CARG RS07205
gene id: 1348662:CARG_RS07205
uniprot id: U3GY61
names: Similarity
messages: Belongs to the peptidase S33 family.

1348662:CARG RS07405
gene id: 1348662:CARG_RS07405
uniprot id: U3GY88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1348662:CARG RS02910
gene id: 1348662:CARG_RS02910
uniprot id: U3GTW1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1348662:CARG RS07075
gene id: 1348662:CARG_RS07075
uniprot id: U3GZR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1348662:CARG RS08695
gene id: 1348662:CARG_RS08695
uniprot id: U3GYN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

1348662:CARG RS03100
gene id: 1348662:CARG_RS03100
uniprot id: U3GXL7
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS09290
gene id: 1348662:CARG_RS09290
uniprot id: U3H009
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1348662:CARG RS04530
gene id: 1348662:CARG_RS04530
uniprot id: U3GY36
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS08945
gene id: 1348662:CARG_RS08945
uniprot id: U3GZF3
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS05170
gene id: 1348662:CARG_RS05170
uniprot id: U3GXI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1348662:CARG RS06350
gene id: 1348662:CARG_RS06350
uniprot id: U3GYQ3
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

1348662:CARG RS08305
gene id: 1348662:CARG_RS08305
uniprot id: U3GYI3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1348662:CARG RS00490
gene id: 1348662:CARG_RS00490
uniprot id: U3GSA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS00860
gene id: 1348662:CARG_RS00860
uniprot id: U3GY29
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1348662:CARG RS06440
gene id: 1348662:CARG_RS06440
uniprot id: U3GVA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

1348662:CARG RS05240
gene id: 1348662:CARG_RS05240
uniprot id: U3GZF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS05640
gene id: 1348662:CARG_RS05640
uniprot id: U3GVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Membrane

1348662:CARG RS05660
gene id: 1348662:CARG_RS05660
uniprot id: U3GW63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS01345
gene id: 1348662:CARG_RS01345
uniprot id: U3GSD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1348662:CARG RS08925
gene id: 1348662:CARG_RS08925
uniprot id: U3GZF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

1348662:CARG RS03580
gene id: 1348662:CARG_RS03580
uniprot id: U3GZ02
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1348662:CARG RS04195
gene id: 1348662:CARG_RS04195
uniprot id: U3GXZ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1348662:CARG RS01210
gene id: 1348662:CARG_RS01210
uniprot id: U3GT01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1348662:CARG RS09345
gene id: 1348662:CARG_RS09345
uniprot id: U3GYW1
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

1348662:CARG RS00725
gene id: 1348662:CARG_RS00725
uniprot id: U3GWJ0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1348662:CARG RS05705
gene id: 1348662:CARG_RS05705
uniprot id: U3GUW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1348662:CARG RS06975
gene id: 1348662:CARG_RS06975
uniprot id: U3GY34
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS06300
gene id: 1348662:CARG_RS06300
uniprot id: U3GZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1348662:CARG RS08410
gene id: 1348662:CARG_RS08410
uniprot id: U3GWA2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1348662:CARG RS00720
gene id: 1348662:CARG_RS00720
uniprot id: U3GSD7
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

1348662:CARG RS04765
gene id: 1348662:CARG_RS04765
uniprot id: U3GUV5
names: Similarity
messages: Belongs to the UPF0098 family.

1348662:CARG RS06325
gene id: 1348662:CARG_RS06325
uniprot id: U3GZN1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1348662:CARG RS03325
gene id: 1348662:CARG_RS03325
uniprot id: U3GTM8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1348662:CARG RS07280
gene id: 1348662:CARG_RS07280
uniprot id: U3GZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1348662:CARG RS05960
gene id: 1348662:CARG_RS05960
uniprot id: U3GUZ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1348662:CARG RS04845
gene id: 1348662:CARG_RS04845
uniprot id: U3GUX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06255
gene id: 1348662:CARG_RS06255
uniprot id: U3GXU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1348662:CARG RS05710
gene id: 1348662:CARG_RS05710
uniprot id: U3GYH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

1348662:CARG RS01420
gene id: 1348662:CARG_RS01420
uniprot id: U3GT27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1348662:CARG RS07945
gene id: 1348662:CARG_RS07945
uniprot id: U3GW68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1348662:CARG RS05825
gene id: 1348662:CARG_RS05825
uniprot id: U3GVG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1348662:CARG RS08515
gene id: 1348662:CARG_RS08515
uniprot id: U3GZX6
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1348662:CARG RS04905
gene id: 1348662:CARG_RS04905
uniprot id: U3GY87
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1348662:CARG RS06835
gene id: 1348662:CARG_RS06835
uniprot id: U3GYW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1348662:CARG RS01245
gene id: 1348662:CARG_RS01245
uniprot id: U3GSM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1348662:CARG RS01870
gene id: 1348662:CARG_RS01870
uniprot id: U3GT98
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1348662:CARG RS06480
gene id: 1348662:CARG_RS06480
uniprot id: U3GVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

1348662:CARG RS04040
gene id: 1348662:CARG_RS04040
uniprot id: U3GXX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1348662:CARG RS04670
gene id: 1348662:CARG_RS04670
uniprot id: U3GUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1348662:CARG RS01265
gene id: 1348662:CARG_RS01265
uniprot id: U3GW33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS08030
gene id: 1348662:CARG_RS08030
uniprot id: U3GSF6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

1348662:CARG RS00685
gene id: 1348662:CARG_RS00685
uniprot id: U3GY09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1348662:CARG RS01235
gene id: 1348662:CARG_RS01235
uniprot id: U3GVE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS07835
gene id: 1348662:CARG_RS07835
uniprot id: U3GW11
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

1348662:CARG RS08035
gene id: 1348662:CARG_RS08035
uniprot id: U3GW42
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

1348662:CARG RS06370
gene id: 1348662:CARG_RS06370
uniprot id: U3GV90
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

1348662:CARG RS06690
gene id: 1348662:CARG_RS06690
uniprot id: U3GZP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

1348662:CARG RS04295
gene id: 1348662:CARG_RS04295
uniprot id: U3GY07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1348662:CARG RS09025
gene id: 1348662:CARG_RS09025
uniprot id: U3GX78
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

1348662:CARG RS03830
gene id: 1348662:CARG_RS03830
uniprot id: U3GZ32
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

1348662:CARG RS00500
gene id: 1348662:CARG_RS00500
uniprot id: U3GXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

1348662:CARG RS02845
gene id: 1348662:CARG_RS02845
uniprot id: U3GTF0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

1348662:CARG RS07040
gene id: 1348662:CARG_RS07040
uniprot id: U3GVM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

1348662:CARG RS05055
gene id: 1348662:CARG_RS05055
uniprot id: U3GUL7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS06470
gene id: 1348662:CARG_RS06470
uniprot id: U3GZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1348662:CARG RS08930
gene id: 1348662:CARG_RS08930
uniprot id: U3GYR6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1348662:CARG RS03445
gene id: 1348662:CARG_RS03445
uniprot id: U3GU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1348662:CARG RS07435
gene id: 1348662:CARG_RS07435
uniprot id: U3GZT5
names: Similarity
messages: Belongs to the peptidase M1 family.

1348662:CARG RS01455
gene id: 1348662:CARG_RS01455
uniprot id: U3GXS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1348662:CARG RS08820
gene id: 1348662:CARG_RS08820
uniprot id: U3GZY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1348662:CARG RS06460
gene id: 1348662:CARG_RS06460
uniprot id: U3GVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

1348662:CARG RS07370
gene id: 1348662:CARG_RS07370
uniprot id: U3GZ39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1348662:CARG RS04245
gene id: 1348662:CARG_RS04245
uniprot id: U3GY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1348662:CARG RS07305
gene id: 1348662:CARG_RS07305
uniprot id: U3GZT0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1348662:CARG RS08565
gene id: 1348662:CARG_RS08565
uniprot id: U3GZC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

1348662:CARG RS00780
gene id: 1348662:CARG_RS00780
uniprot id: U3GWK0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

1348662:CARG RS00845
gene id: 1348662:CARG_RS00845
uniprot id: U3GSU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1348662:CARG RS07335
gene id: 1348662:CARG_RS07335
uniprot id: U3GY76
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1348662:CARG RS02745
gene id: 1348662:CARG_RS02745
uniprot id: U3GTD2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1348662:CARG RS05025
gene id: 1348662:CARG_RS05025
uniprot id: U3GV29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1348662:CARG RS03560
gene id: 1348662:CARG_RS03560
uniprot id: U3GWM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1348662:CARG RS01145
gene id: 1348662:CARG_RS01145
uniprot id: U3GWS3
names: Similarity
messages: Belongs to the neocarzinostatin family.

1348662:CARG RS06525
gene id: 1348662:CARG_RS06525
uniprot id: U3GXX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

1348662:CARG RS06755
gene id: 1348662:CARG_RS06755
uniprot id: U3GVH2
names: Similarity
messages: Belongs to the glutamine synthetase family.

1348662:CARG RS00040
gene id: 1348662:CARG_RS00040
uniprot id: U3GUU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1348662:CARG RS04970
gene id: 1348662:CARG_RS04970
uniprot id: U3GXF3
names: Subcellular Location Annotation
messages: Membrane

1348662:CARG RS03720
gene id: 1348662:CARG_RS03720
uniprot id: U3GTV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

1348662:CARG RS04630
gene id: 1348662:CARG_RS04630
uniprot id: U3GY50
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.