1343739:PAP RS06265
gene id: 1343739:PAP_RS06265
uniprot id: A0A075LTK0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1343739:PAP RS01710
gene id: 1343739:PAP_RS01710
uniprot id: A0A075LS56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS00795
gene id: 1343739:PAP_RS00795
uniprot id: A0A075LR98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1343739:PAP RS04635
gene id: 1343739:PAP_RS04635
uniprot id: A0A075LXQ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1343739:PAP RS04750
gene id: 1343739:PAP_RS04750
uniprot id: A0A075LTR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1343739:PAP RS00345
gene id: 1343739:PAP_RS00345
uniprot id: A0A075LP92
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS06980
gene id: 1343739:PAP_RS06980
uniprot id: A0A075LZ15
names: Similarity
messages: Belongs to the RuvB family.

1343739:PAP RS02210
gene id: 1343739:PAP_RS02210
uniprot id: A0A075LSE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1343739:PAP RS10055
gene id: 1343739:PAP_RS10055
uniprot id: A0A075LW40
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1343739:PAP RS01450
gene id: 1343739:PAP_RS01450
uniprot id: A0A075LRJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05895
gene id: 1343739:PAP_RS05895
uniprot id: A0A075LS80
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS02790
gene id: 1343739:PAP_RS02790
uniprot id: A0A075LS69
names: Similarity
messages: Belongs to the UPF0145 family.

1343739:PAP RS04605
gene id: 1343739:PAP_RS04605
uniprot id: A0A075LTP4
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

1343739:PAP RS09960
gene id: 1343739:PAP_RS09960
uniprot id: A0A075LWI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1343739:PAP RS07910
gene id: 1343739:PAP_RS07910
uniprot id: A0A075LZI4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

1343739:PAP RS01945
gene id: 1343739:PAP_RS01945
uniprot id: A0A075LWD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1343739:PAP RS01415
gene id: 1343739:PAP_RS01415
uniprot id: A0A075LQZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05860
gene id: 1343739:PAP_RS05860
uniprot id: A0A075LYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

1343739:PAP RS02340
gene id: 1343739:PAP_RS02340
uniprot id: A0A075LSG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS05955
gene id: 1343739:PAP_RS05955
uniprot id: A0A075LYF3
names: Similarity
messages: Belongs to the peptidase U62 family.

1343739:PAP RS09355
gene id: 1343739:PAP_RS09355
uniprot id: A0A075M0H6
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1343739:PAP RS03080
gene id: 1343739:PAP_RS03080
uniprot id: A0A075LWW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

1343739:PAP RS08815
gene id: 1343739:PAP_RS08815
uniprot id: A0A075LTY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1343739:PAP RS01685
gene id: 1343739:PAP_RS01685
uniprot id: A0A075LS52
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07905
gene id: 1343739:PAP_RS07905
uniprot id: A0A075LVG5
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1343739:PAP RS00435
gene id: 1343739:PAP_RS00435
uniprot id: A0A075LRC9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1343739:PAP RS00670
gene id: 1343739:PAP_RS00670
uniprot id: A0A075LRI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1343739:PAP RS07120
gene id: 1343739:PAP_RS07120
uniprot id: A0A075LV20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1343739:PAP RS02795
gene id: 1343739:PAP_RS02795
uniprot id: A0A075LSP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1343739:PAP RS02755
gene id: 1343739:PAP_RS02755
uniprot id: A0A075LRL7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS00570
gene id: 1343739:PAP_RS00570
uniprot id: A0A075LVR4
names: Similarity
messages: Belongs to the GARS family.

1343739:PAP RS05355
gene id: 1343739:PAP_RS05355
uniprot id: A0A075LTP1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1343739:PAP RS04835
gene id: 1343739:PAP_RS04835
uniprot id: A0A075LSU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS00135
gene id: 1343739:PAP_RS00135
uniprot id: A0A075LQ63
names: Similarity
messages: Belongs to the UPF0200 family.

1343739:PAP RS02900
gene id: 1343739:PAP_RS02900
uniprot id: A0A075LSR7
names: Similarity
messages: Belongs to the peptidase M24B family.

1343739:PAP RS08795
gene id: 1343739:PAP_RS08795
uniprot id: A0A075LVL7
names: Similarity
messages: Belongs to the glutaredoxin family.

1343739:PAP RS07890
gene id: 1343739:PAP_RS07890
uniprot id: A0A075LUF1
names: Similarity
messages: Belongs to the arginase family.

1343739:PAP RS05440
gene id: 1343739:PAP_RS05440
uniprot id: A0A075LY41
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS05370
gene id: 1343739:PAP_RS05370
uniprot id: A0A075LT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

1343739:PAP RS04120
gene id: 1343739:PAP_RS04120
uniprot id: A0A075LTF7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1343739:PAP RS08255
gene id: 1343739:PAP_RS08255
uniprot id: A0A075LUL8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1343739:PAP RS09390
gene id: 1343739:PAP_RS09390
uniprot id: A0A075LVT1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1343739:PAP RS00895
gene id: 1343739:PAP_RS00895
uniprot id: A0A075LRB4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1343739:PAP RS01905
gene id: 1343739:PAP_RS01905
uniprot id: A0A075LRS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1343739:PAP RS04885
gene id: 1343739:PAP_RS04885
uniprot id: A0A075LSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1343739:PAP RS05315
gene id: 1343739:PAP_RS05315
uniprot id: A0A075LT34
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1343739:PAP RS04600
gene id: 1343739:PAP_RS04600
uniprot id: A0A075LT86
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1343739:PAP RS02145
gene id: 1343739:PAP_RS02145
uniprot id: A0A075LWG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1343739:PAP RS01300
gene id: 1343739:PAP_RS01300
uniprot id: A0A075LRZ0
names: Similarity
messages: Belongs to the peptidase S8 family.

1343739:PAP RS03480
gene id: 1343739:PAP_RS03480
uniprot id: A0A075LT57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1343739:PAP RS04115
gene id: 1343739:PAP_RS04115
uniprot id: A0A075LT04
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

1343739:PAP RS08810
gene id: 1343739:PAP_RS08810
uniprot id: A0A075LV27
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1343739:PAP RS04595
gene id: 1343739:PAP_RS04595
uniprot id: A0A075LRH6
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01650
gene id: 1343739:PAP_RS01650
uniprot id: A0A075LQ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1343739:PAP RS07800
gene id: 1343739:PAP_RS07800
uniprot id: A0A075LVE2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1343739:PAP RS02350
gene id: 1343739:PAP_RS02350
uniprot id: A0A075LRE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS03095
gene id: 1343739:PAP_RS03095
uniprot id: A0A075LSD8
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

1343739:PAP RS07330
gene id: 1343739:PAP_RS07330
uniprot id: A0A075LSZ7
names: Similarity
messages: Belongs to the UPF0047 family.

1343739:PAP RS09680
gene id: 1343739:PAP_RS09680
uniprot id: A0A075LVX3
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

1343739:PAP RS07165
gene id: 1343739:PAP_RS07165
uniprot id: A0A075LV30
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00840
gene id: 1343739:PAP_RS00840
uniprot id: A0A075LPM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1343739:PAP RS03800
gene id: 1343739:PAP_RS03800
uniprot id: A0A075LR34
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS02185
gene id: 1343739:PAP_RS02185
uniprot id: A0A075LRX9
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1343739:PAP RS06170
gene id: 1343739:PAP_RS06170
uniprot id: A0A075LU41
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02620
gene id: 1343739:PAP_RS02620
uniprot id: A0A075LWN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1343739:PAP RS08470
gene id: 1343739:PAP_RS08470
uniprot id: A0A075LVU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1343739:PAP RS02770
gene id: 1343739:PAP_RS02770
uniprot id: A0A075LSP0
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS05220
gene id: 1343739:PAP_RS05220
uniprot id: A0A075LT20
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1343739:PAP RS03110
gene id: 1343739:PAP_RS03110
uniprot id: A0A075LRU6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1343739:PAP RS03400
gene id: 1343739:PAP_RS03400
uniprot id: A0A075LSN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS02600
gene id: 1343739:PAP_RS02600
uniprot id: A0A075LRJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS04300
gene id: 1343739:PAP_RS04300
uniprot id: A0A075LXK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1343739:PAP RS05260
gene id: 1343739:PAP_RS05260
uniprot id: A0A075LTM6
names: Similarity
messages: Belongs to the DEAD box helicase family.

1343739:PAP RS04655
gene id: 1343739:PAP_RS04655
uniprot id: A0A075LTQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1343739:PAP RS08915
gene id: 1343739:PAP_RS08915
uniprot id: A0A075LU05
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1343739:PAP RS01330
gene id: 1343739:PAP_RS01330
uniprot id: A0A075LW71
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

1343739:PAP RS04100
gene id: 1343739:PAP_RS04100
uniprot id: A0A075LXF6
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.

1343739:PAP RS01335
gene id: 1343739:PAP_RS01335
uniprot id: A0A075LPV0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1343739:PAP RS01715
gene id: 1343739:PAP_RS01715
uniprot id: A0A075LWB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1343739:PAP RS05365
gene id: 1343739:PAP_RS05365
uniprot id: A0A075LY25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1343739:PAP RS02135
gene id: 1343739:PAP_RS02135
uniprot id: A0A075LRX0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1343739:PAP RS03825
gene id: 1343739:PAP_RS03825
uniprot id: A0A075LR39
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1343739:PAP RS07560
gene id: 1343739:PAP_RS07560
uniprot id: A0A075LU85
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1343739:PAP RS02785
gene id: 1343739:PAP_RS02785
uniprot id: A0A075LQI9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09770
gene id: 1343739:PAP_RS09770
uniprot id: A0A075LUH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

1343739:PAP RS02375
gene id: 1343739:PAP_RS02375
uniprot id: A0A075LRF4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02945
gene id: 1343739:PAP_RS02945
uniprot id: A0A075LSA0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1343739:PAP RS02315
gene id: 1343739:PAP_RS02315
uniprot id: A0A075LRZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1343739:PAP RS05130
gene id: 1343739:PAP_RS05130
uniprot id: A0A075LU01
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1343739:PAP RS09095
gene id: 1343739:PAP_RS09095
uniprot id: A0A075LV78
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1343739:PAP RS09980
gene id: 1343739:PAP_RS09980
uniprot id: A0A075LW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05785
gene id: 1343739:PAP_RS05785
uniprot id: A0A075LYA2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1343739:PAP RS02150
gene id: 1343739:PAP_RS02150
uniprot id: A0A075LRA9
names: Similarity
messages: Belongs to the UPF0440 family.

1343739:PAP RS02675
gene id: 1343739:PAP_RS02675
uniprot id: A0A075LRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS01550
gene id: 1343739:PAP_RS01550
uniprot id: A0A075LRL4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS03595
gene id: 1343739:PAP_RS03595
uniprot id: A0A075LSS5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1343739:PAP RS05650
gene id: 1343739:PAP_RS05650
uniprot id: A0A075LTU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1343739:PAP RS03450
gene id: 1343739:PAP_RS03450
uniprot id: A0A075LSP9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00430
gene id: 1343739:PAP_RS00430
uniprot id: A0A075LQZ3
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00735
gene id: 1343739:PAP_RS00735
uniprot id: A0A075LQM9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00560
gene id: 1343739:PAP_RS00560
uniprot id: A0A075LR28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1343739:PAP RS01510
gene id: 1343739:PAP_RS01510
uniprot id: A0A075LW88
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

1343739:PAP RS03045
gene id: 1343739:PAP_RS03045
uniprot id: A0A075LSC7
names: Similarity
messages: Belongs to the RutC family.

1343739:PAP RS02725
gene id: 1343739:PAP_RS02725
uniprot id: A0A075LRL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS05645
gene id: 1343739:PAP_RS05645
uniprot id: A0A075LRZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1343739:PAP RS08770
gene id: 1343739:PAP_RS08770
uniprot id: A0A075LVL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

1343739:PAP RS04790
gene id: 1343739:PAP_RS04790
uniprot id: A0A075LRK6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1343739:PAP RS02695
gene id: 1343739:PAP_RS02695
uniprot id: A0A075LWP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1343739:PAP RS01815
gene id: 1343739:PAP_RS01815
uniprot id: A0A075LS75
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS04075
gene id: 1343739:PAP_RS04075
uniprot id: A0A075LXF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1343739:PAP RS05770
gene id: 1343739:PAP_RS05770
uniprot id: A0A075LS23
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

1343739:PAP RS09525
gene id: 1343739:PAP_RS09525
uniprot id: A0A075LVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS09470
gene id: 1343739:PAP_RS09470
uniprot id: A0A075LW95
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1343739:PAP RS09540
gene id: 1343739:PAP_RS09540
uniprot id: A0A075LWB1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

1343739:PAP RS07020
gene id: 1343739:PAP_RS07020
uniprot id: A0A075LUK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1343739:PAP RS01120
gene id: 1343739:PAP_RS01120
uniprot id: A0A075LRE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS00340
gene id: 1343739:PAP_RS00340
uniprot id: A0A075LQB5
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09085
gene id: 1343739:PAP_RS09085
uniprot id: A0A075LW34
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1343739:PAP RS01455
gene id: 1343739:PAP_RS01455
uniprot id: A0A075LS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05555
gene id: 1343739:PAP_RS05555
uniprot id: A0A075LY59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1343739:PAP RS08455
gene id: 1343739:PAP_RS08455
uniprot id: A0A075LUV4
names: Similarity
messages: Belongs to the AOR/FOR family.

1343739:PAP RS04625
gene id: 1343739:PAP_RS04625
uniprot id: A0A075LT91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1343739:PAP RS00160
gene id: 1343739:PAP_RS00160
uniprot id: A0A075LQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS09325
gene id: 1343739:PAP_RS09325
uniprot id: A0A075LW70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

1343739:PAP RS09285
gene id: 1343739:PAP_RS09285
uniprot id: A0A075LU78
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01690
gene id: 1343739:PAP_RS01690
uniprot id: A0A075LWA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1343739:PAP RS03360
gene id: 1343739:PAP_RS03360
uniprot id: A0A075LX29
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1343739:PAP RS08095
gene id: 1343739:PAP_RS08095
uniprot id: A0A075LV71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1343739:PAP RS09295
gene id: 1343739:PAP_RS09295
uniprot id: A0A075LW65
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1343739:PAP RS00550
gene id: 1343739:PAP_RS00550
uniprot id: A0A075LQG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1343739:PAP RS03685
gene id: 1343739:PAP_RS03685
uniprot id: A0A075LX77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

1343739:PAP RS01925
gene id: 1343739:PAP_RS01925
uniprot id: A0A075LR68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS07460
gene id: 1343739:PAP_RS07460
uniprot id: A0A075LV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

1343739:PAP RS00655
gene id: 1343739:PAP_RS00655
uniprot id: A0A075LQI7
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

1343739:PAP RS01720
gene id: 1343739:PAP_RS01720
uniprot id: A0A075LR37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1343739:PAP RS03750
gene id: 1343739:PAP_RS03750
uniprot id: A0A075LSV2
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS06545
gene id: 1343739:PAP_RS06545
uniprot id: A0A075LUB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1343739:PAP RS01310
gene id: 1343739:PAP_RS01310
uniprot id: A0A075LQX6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1343739:PAP RS07875
gene id: 1343739:PAP_RS07875
uniprot id: A0A075LV32
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1343739:PAP RS00620
gene id: 1343739:PAP_RS00620
uniprot id: A0A075LRH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1343739:PAP RS05030
gene id: 1343739:PAP_RS05030
uniprot id: A0A075LXX2
names: Similarity
messages: Belongs to the DtxR/MntR family.

1343739:PAP RS07655
gene id: 1343739:PAP_RS07655
uniprot id: A0A075LZE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1343739:PAP RS02400
gene id: 1343739:PAP_RS02400
uniprot id: A0A075LRF9
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

1343739:PAP RS03430
gene id: 1343739:PAP_RS03430
uniprot id: A0A075LT48
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1343739:PAP RS01790
gene id: 1343739:PAP_RS01790
uniprot id: A0A075LWB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1343739:PAP RS06135
gene id: 1343739:PAP_RS06135
uniprot id: A0A075LTI4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1343739:PAP RS00390
gene id: 1343739:PAP_RS00390
uniprot id: A0A075LVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS00585
gene id: 1343739:PAP_RS00585
uniprot id: A0A075LR32
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1343739:PAP RS03845
gene id: 1343739:PAP_RS03845
uniprot id: A0A075LSD4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1343739:PAP RS02360
gene id: 1343739:PAP_RS02360
uniprot id: A0A075LS07
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02020
gene id: 1343739:PAP_RS02020
uniprot id: A0A075LWE3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1343739:PAP RS01910
gene id: 1343739:PAP_RS01910
uniprot id: A0A075LS91
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1343739:PAP RS09345
gene id: 1343739:PAP_RS09345
uniprot id: A0A075LVS5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1343739:PAP RS05775
gene id: 1343739:PAP_RS05775
uniprot id: A0A075LTX8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS09245
gene id: 1343739:PAP_RS09245
uniprot id: A0A075LW57
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1343739:PAP RS07630
gene id: 1343739:PAP_RS07630
uniprot id: A0A075LZE4
names: Function
messages: Part of a potassium transport system.

1343739:PAP RS05090
gene id: 1343739:PAP_RS05090
uniprot id: A0A075LSZ8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1343739:PAP RS03985
gene id: 1343739:PAP_RS03985
uniprot id: A0A075LSZ2
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07130
gene id: 1343739:PAP_RS07130
uniprot id: A0A075LTY7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1343739:PAP RS02080
gene id: 1343739:PAP_RS02080
uniprot id: A0A075LQ79
names: Function
messages: Probably involved in the biogenesis of the ribosome.

1343739:PAP RS03840
gene id: 1343739:PAP_RS03840
uniprot id: A0A075LXA7
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

1343739:PAP RS01915
gene id: 1343739:PAP_RS01915
uniprot id: A0A075LWD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS10035
gene id: 1343739:PAP_RS10035
uniprot id: A0A075LWJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1343739:PAP RS05780
gene id: 1343739:PAP_RS05780
uniprot id: A0A075LUB4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

1343739:PAP RS09995
gene id: 1343739:PAP_RS09995
uniprot id: A0A075LVP9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

1343739:PAP RS03950
gene id: 1343739:PAP_RS03950
uniprot id: A0A075LSF5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1343739:PAP RS06945
gene id: 1343739:PAP_RS06945
uniprot id: A0A075LUY5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

1343739:PAP RS04685
gene id: 1343739:PAP_RS04685
uniprot id: A0A075LXR5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1343739:PAP RS00870
gene id: 1343739:PAP_RS00870
uniprot id: A0A075LRB0
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01935
gene id: 1343739:PAP_RS01935
uniprot id: A0A075LRT0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1343739:PAP RS07730
gene id: 1343739:PAP_RS07730
uniprot id: A0A075LZG0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1343739:PAP RS05125
gene id: 1343739:PAP_RS05125
uniprot id: A0A075LTJ9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09365
gene id: 1343739:PAP_RS09365
uniprot id: A0A075LU92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1343739:PAP RS03105
gene id: 1343739:PAP_RS03105
uniprot id: A0A075LWW9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

1343739:PAP RS07780
gene id: 1343739:PAP_RS07780
uniprot id: A0A075LZG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1343739:PAP RS06490
gene id: 1343739:PAP_RS06490
uniprot id: A0A075LUA0
names: Similarity
messages: Belongs to the MoaB/Mog family.

1343739:PAP RS08845
gene id: 1343739:PAP_RS08845
uniprot id: A0A075LVM4
names: Similarity
messages: Belongs to the AOR/FOR family.

1343739:PAP RS06905
gene id: 1343739:PAP_RS06905
uniprot id: A0A075LTU5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS00775
gene id: 1343739:PAP_RS00775
uniprot id: A0A075LRN4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS04250
gene id: 1343739:PAP_RS04250
uniprot id: A0A075LXJ2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1343739:PAP RS10020
gene id: 1343739:PAP_RS10020
uniprot id: A0A075LVQ3
names: Similarity
messages: Belongs to the UPF0111 family.

1343739:PAP RS04990
gene id: 1343739:PAP_RS04990
uniprot id: A0A075LRP0
names: Similarity
messages: Belongs to the peptidase M20A family.

1343739:PAP RS00980
gene id: 1343739:PAP_RS00980
uniprot id: A0A075LW20
names: Similarity
messages: Belongs to the AOR/FOR family.

1343739:PAP RS03730
gene id: 1343739:PAP_RS03730
uniprot id: A0A075LT97
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00955
gene id: 1343739:PAP_RS00955
uniprot id: A0A075LW16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1343739:PAP RS04235
gene id: 1343739:PAP_RS04235
uniprot id: A0A075LSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1343739:PAP RS00680
gene id: 1343739:PAP_RS00680
uniprot id: A0A075LQJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1343739:PAP RS00090
gene id: 1343739:PAP_RS00090
uniprot id: A0A075LQR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1343739:PAP RS01835
gene id: 1343739:PAP_RS01835
uniprot id: A0A075LQ34
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS03835
gene id: 1343739:PAP_RS03835
uniprot id: A0A075LTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1343739:PAP RS04390
gene id: 1343739:PAP_RS04390
uniprot id: A0A075LSL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1343739:PAP RS02215
gene id: 1343739:PAP_RS02215
uniprot id: A0A075LWH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1343739:PAP RS04780
gene id: 1343739:PAP_RS04780
uniprot id: A0A075LXT3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1343739:PAP RS03455
gene id: 1343739:PAP_RS03455
uniprot id: A0A075LT52
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1343739:PAP RS03585
gene id: 1343739:PAP_RS03585
uniprot id: A0A075LS85
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1343739:PAP RS01760
gene id: 1343739:PAP_RS01760
uniprot id: A0A075LS66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1343739:PAP RS01670
gene id: 1343739:PAP_RS01670
uniprot id: A0A075LR30
names: Similarity
messages: Belongs to the peptidase S8 family.

1343739:PAP RS07815
gene id: 1343739:PAP_RS07815
uniprot id: A0A075LT95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1343739:PAP RS08000
gene id: 1343739:PAP_RS08000
uniprot id: A0A075LVI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1343739:PAP RS08025
gene id: 1343739:PAP_RS08025
uniprot id: A0A075LVI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

1343739:PAP RS02530
gene id: 1343739:PAP_RS02530
uniprot id: A0A075LQE7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1343739:PAP RS06315
gene id: 1343739:PAP_RS06315
uniprot id: A0A075LTK3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1343739:PAP RS00975
gene id: 1343739:PAP_RS00975
uniprot id: A0A075LRT6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1343739:PAP RS01210
gene id: 1343739:PAP_RS01210
uniprot id: A0A075LQW0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1343739:PAP RS03025
gene id: 1343739:PAP_RS03025
uniprot id: A0A075LSU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1343739:PAP RS08130
gene id: 1343739:PAP_RS08130
uniprot id: A0A075LZN9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02030
gene id: 1343739:PAP_RS02030
uniprot id: A0A075LQ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1343739:PAP RS01880
gene id: 1343739:PAP_RS01880
uniprot id: A0A075LP09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1343739:PAP RS01900
gene id: 1343739:PAP_RS01900
uniprot id: A0A075LQ40
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1343739:PAP RS04960
gene id: 1343739:PAP_RS04960
uniprot id: A0A075LSX6
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1343739:PAP RS01795
gene id: 1343739:PAP_RS01795
uniprot id: A0A075LR53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1343739:PAP RS07240
gene id: 1343739:PAP_RS07240
uniprot id: A0A075LU08
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1343739:PAP RS07750
gene id: 1343739:PAP_RS07750
uniprot id: A0A075LVD4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS04230
gene id: 1343739:PAP_RS04230
uniprot id: A0A075LXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS02750
gene id: 1343739:PAP_RS02750
uniprot id: A0A075LWQ4
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1343739:PAP RS06675
gene id: 1343739:PAP_RS06675
uniprot id: A0A075LYV3
names: Similarity
messages: Belongs to the FUN14 family.

1343739:PAP RS02815
gene id: 1343739:PAP_RS02815
uniprot id: A0A075LS73
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

1343739:PAP RS06590
gene id: 1343739:PAP_RS06590
uniprot id: A0A075LUC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1343739:PAP RS02410
gene id: 1343739:PAP_RS02410
uniprot id: A0A075LS14
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1343739:PAP RS02925
gene id: 1343739:PAP_RS02925
uniprot id: A0A075LSS2
names: Similarity
messages: Belongs to the HypE family.

1343739:PAP RS01290
gene id: 1343739:PAP_RS01290
uniprot id: A0A075LPU1
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02525
gene id: 1343739:PAP_RS02525
uniprot id: A0A075LRI3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1343739:PAP RS02110
gene id: 1343739:PAP_RS02110
uniprot id: A0A075LRW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS07150
gene id: 1343739:PAP_RS07150
uniprot id: A0A075LZ51
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS08230
gene id: 1343739:PAP_RS08230
uniprot id: A0A075LP15
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1343739:PAP RS09235
gene id: 1343739:PAP_RS09235
uniprot id: A0A075LU67
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1343739:PAP RS00645
gene id: 1343739:PAP_RS00645
uniprot id: A0A075LRH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1343739:PAP RS00595
gene id: 1343739:PAP_RS00595
uniprot id: A0A075LVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1343739:PAP RS02860
gene id: 1343739:PAP_RS02860
uniprot id: A0A075LRP1
names: Similarity
messages: Belongs to the UPF0127 family.

1343739:PAP RS01960
gene id: 1343739:PAP_RS01960
uniprot id: A0A075LRT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS03240
gene id: 1343739:PAP_RS03240
uniprot id: A0A075LRZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS04340
gene id: 1343739:PAP_RS04340
uniprot id: A0A075LSL1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1343739:PAP RS04965
gene id: 1343739:PAP_RS04965
uniprot id: A0A075LRN7
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS08610
gene id: 1343739:PAP_RS08610
uniprot id: A0A075LUY7
names: Similarity
messages: Belongs to the AAA ATPase family.

1343739:PAP RS01505
gene id: 1343739:PAP_RS01505
uniprot id: A0A075LS25
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

1343739:PAP RS06605
gene id: 1343739:PAP_RS06605
uniprot id: A0A075LTP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1343739:PAP RS01040
gene id: 1343739:PAP_RS01040
uniprot id: A0A075LPQ2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1343739:PAP RS03170
gene id: 1343739:PAP_RS03170
uniprot id: A0A075LSF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1343739:PAP RS03300
gene id: 1343739:PAP_RS03300
uniprot id: A0A075LSL9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

1343739:PAP RS04080
gene id: 1343739:PAP_RS04080
uniprot id: A0A075LSH9
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

1343739:PAP RS05120
gene id: 1343739:PAP_RS05120
uniprot id: A0A075LRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS08970
gene id: 1343739:PAP_RS08970
uniprot id: A0A075LV66
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1343739:PAP RS04740
gene id: 1343739:PAP_RS04740
uniprot id: A0A075LSS8
names: Similarity
messages: Belongs to the DtxR/MntR family.

1343739:PAP RS01180
gene id: 1343739:PAP_RS01180
uniprot id: A0A075LW50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS03530
gene id: 1343739:PAP_RS03530
uniprot id: A0A075LT65
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1343739:PAP RS02075
gene id: 1343739:PAP_RS02075
uniprot id: A0A075LR94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS10000
gene id: 1343739:PAP_RS10000
uniprot id: A0A075LUL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1343739:PAP RS02820
gene id: 1343739:PAP_RS02820
uniprot id: A0A075LSP8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1343739:PAP RS02955
gene id: 1343739:PAP_RS02955
uniprot id: A0A075LWU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1343739:PAP RS02875
gene id: 1343739:PAP_RS02875
uniprot id: A0A075LSR0
names: Similarity
messages: Belongs to the UPF0166 family.

1343739:PAP RS00010
gene id: 1343739:PAP_RS00010
uniprot id: A0A075LQ39
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1343739:PAP RS03560
gene id: 1343739:PAP_RS03560
uniprot id: A0A075LS81
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1343739:PAP RS04055
gene id: 1343739:PAP_RS04055
uniprot id: A0A075LR74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1343739:PAP RS02050
gene id: 1343739:PAP_RS02050
uniprot id: A0A075LR90
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1343739:PAP RS06330
gene id: 1343739:PAP_RS06330
uniprot id: A0A075LUL7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

1343739:PAP RS01440
gene id: 1343739:PAP_RS01440
uniprot id: A0A075LQZ5
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

1343739:PAP RS01765
gene id: 1343739:PAP_RS01765
uniprot id: A0A075LWB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS00120
gene id: 1343739:PAP_RS00120
uniprot id: A0A075LQS2
names: Similarity
messages: Belongs to the UPF0201 family.

1343739:PAP RS01170
gene id: 1343739:PAP_RS01170
uniprot id: A0A075LRF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS04620
gene id: 1343739:PAP_RS04620
uniprot id: A0A075LRI0
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1343739:PAP RS03205
gene id: 1343739:PAP_RS03205
uniprot id: A0A075LSX5
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09180
gene id: 1343739:PAP_RS09180
uniprot id: A0A075LR47
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

1343739:PAP RS05225
gene id: 1343739:PAP_RS05225
uniprot id: A0A075LRS9
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1343739:PAP RS00020
gene id: 1343739:PAP_RS00020
uniprot id: A0A075LQQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1343739:PAP RS00935
gene id: 1343739:PAP_RS00935
uniprot id: A0A075LQR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1343739:PAP RS04295
gene id: 1343739:PAP_RS04295
uniprot id: A0A075LTJ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01365
gene id: 1343739:PAP_RS01365
uniprot id: A0A075LQY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

1343739:PAP RS08175
gene id: 1343739:PAP_RS08175
uniprot id: A0A075LTH4
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1343739:PAP RS02100
gene id: 1343739:PAP_RS02100
uniprot id: A0A075LR99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS08225
gene id: 1343739:PAP_RS08225
uniprot id: A0A075LUL1
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1343739:PAP RS05495
gene id: 1343739:PAP_RS05495
uniprot id: A0A075LU69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1343739:PAP RS08285
gene id: 1343739:PAP_RS08285
uniprot id: A0A075LTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

1343739:PAP RS01775
gene id: 1343739:PAP_RS01775
uniprot id: A0A075LQ25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1343739:PAP RS05035
gene id: 1343739:PAP_RS05035
uniprot id: A0A075LSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1343739:PAP RS00490
gene id: 1343739:PAP_RS00490
uniprot id: A0A075LVQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1343739:PAP RS00140
gene id: 1343739:PAP_RS00140
uniprot id: A0A075LP46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1343739:PAP RS07435
gene id: 1343739:PAP_RS07435
uniprot id: A0A075LV89
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

1343739:PAP RS07985
gene id: 1343739:PAP_RS07985
uniprot id: A0A075LZK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1343739:PAP RS01050
gene id: 1343739:PAP_RS01050
uniprot id: A0A075LRU9
names: Similarity
messages: Belongs to the BtpA family.

1343739:PAP RS01885
gene id: 1343739:PAP_RS01885
uniprot id: A0A075LWC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS04170
gene id: 1343739:PAP_RS04170
uniprot id: A0A075LT10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1343739:PAP RS02830
gene id: 1343739:PAP_RS02830
uniprot id: A0A075LRN5
names: Similarity
messages: Belongs to the UPF0235 family.

1343739:PAP RS02090
gene id: 1343739:PAP_RS02090
uniprot id: A0A075LSC2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS01155
gene id: 1343739:PAP_RS01155
uniprot id: A0A075LW46
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS05520
gene id: 1343739:PAP_RS05520
uniprot id: A0A075LU72
names: Similarity
messages: Belongs to the peptidase C56 family.

1343739:PAP RS02240
gene id: 1343739:PAP_RS02240
uniprot id: A0A075LWH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1343739:PAP RS05210
gene id: 1343739:PAP_RS05210
uniprot id: A0A075LU17
names: Similarity
messages: Belongs to the UPF0173 family.

1343739:PAP RS01930
gene id: 1343739:PAP_RS01930
uniprot id: A0A075LQ44
names: Similarity
messages: Belongs to the enolase family.

1343739:PAP RS00475
gene id: 1343739:PAP_RS00475
uniprot id: A0A075LPB4
names: Similarity
messages: Belongs to the UPF0111 family.

1343739:PAP RS01805
gene id: 1343739:PAP_RS01805
uniprot id: A0A075LVE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1343739:PAP RS09785
gene id: 1343739:PAP_RS09785
uniprot id: A0A075LVK7
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09915
gene id: 1343739:PAP_RS09915
uniprot id: A0A075M0U3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

1343739:PAP RS03410
gene id: 1343739:PAP_RS03410
uniprot id: A0A075LX39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1343739:PAP RS04730
gene id: 1343739:PAP_RS04730
uniprot id: A0A075LTR0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

1343739:PAP RS06970
gene id: 1343739:PAP_RS06970
uniprot id: A0A075LUZ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

1343739:PAP RS09250
gene id: 1343739:PAP_RS09250
uniprot id: A0A075M0F1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1343739:PAP RS05880
gene id: 1343739:PAP_RS05880
uniprot id: A0A075LUE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01830
gene id: 1343739:PAP_RS01830
uniprot id: A0A075LR56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

1343739:PAP RS03740
gene id: 1343739:PAP_RS03740
uniprot id: A0A075LSB4
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1343739:PAP RS01845
gene id: 1343739:PAP_RS01845
uniprot id: A0A075LS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1343739:PAP RS02335
gene id: 1343739:PAP_RS02335
uniprot id: A0A075LS03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS03215
gene id: 1343739:PAP_RS03215
uniprot id: A0A075LRY5
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1343739:PAP RS01675
gene id: 1343739:PAP_RS01675
uniprot id: A0A075LQ06
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01780
gene id: 1343739:PAP_RS01780
uniprot id: A0A075LRQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS07840
gene id: 1343739:PAP_RS07840
uniprot id: A0A075LTA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1343739:PAP RS03605
gene id: 1343739:PAP_RS03605
uniprot id: A0A075LX63
names: Subunit
messages: Homotetramer.

1343739:PAP RS01620
gene id: 1343739:PAP_RS01620
uniprot id: A0A075LR22
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS08350
gene id: 1343739:PAP_RS08350
uniprot id: A0A075LUR3
names: Similarity
messages: Belongs to the pyruvate kinase family.

1343739:PAP RS01825
gene id: 1343739:PAP_RS01825
uniprot id: A0A075LWC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1343739:PAP RS08220
gene id: 1343739:PAP_RS08220
uniprot id: A0A075LZQ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1343739:PAP RS05710
gene id: 1343739:PAP_RS05710
uniprot id: A0A075LY89
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1343739:PAP RS07680
gene id: 1343739:PAP_RS07680
uniprot id: A0A075LZF4
names: Similarity
messages: Belongs to the UPF0212 family.

1343739:PAP RS09310
gene id: 1343739:PAP_RS09310
uniprot id: A0A075LU82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

1343739:PAP RS07880
gene id: 1343739:PAP_RS07880
uniprot id: A0A075LVF9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1343739:PAP RS00255
gene id: 1343739:PAP_RS00255
uniprot id: A0A075LR91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

1343739:PAP RS08260
gene id: 1343739:PAP_RS08260
uniprot id: A0A075LTJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1343739:PAP RS03810
gene id: 1343739:PAP_RS03810
uniprot id: A0A075LTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

1343739:PAP RS07345
gene id: 1343739:PAP_RS07345
uniprot id: A0A075LZ99
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS08545
gene id: 1343739:PAP_RS08545
uniprot id: A0A075LVV6
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00355
gene id: 1343739:PAP_RS00355
uniprot id: A0A075LRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1343739:PAP RS02625
gene id: 1343739:PAP_RS02625
uniprot id: A0A075LRJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

1343739:PAP RS06260
gene id: 1343739:PAP_RS06260
uniprot id: A0A075LYL1
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1343739:PAP RS02245
gene id: 1343739:PAP_RS02245
uniprot id: A0A075LRC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1343739:PAP RS04690
gene id: 1343739:PAP_RS04690
uniprot id: A0A075LSR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

1343739:PAP RS04280
gene id: 1343739:PAP_RS04280
uniprot id: A0A075LSK6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS06035
gene id: 1343739:PAP_RS06035
uniprot id: A0A075LSA7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1343739:PAP RS05065
gene id: 1343739:PAP_RS05065
uniprot id: A0A075LSZ4
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1343739:PAP RS03915
gene id: 1343739:PAP_RS03915
uniprot id: A0A075LTC8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1343739:PAP RS03570
gene id: 1343739:PAP_RS03570
uniprot id: A0A075LSS1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1343739:PAP RS00745
gene id: 1343739:PAP_RS00745
uniprot id: A0A075LR88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1343739:PAP RS00270
gene id: 1343739:PAP_RS00270
uniprot id: A0A075LP77
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS09790
gene id: 1343739:PAP_RS09790
uniprot id: A0A075LUH6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

1343739:PAP RS09705
gene id: 1343739:PAP_RS09705
uniprot id: A0A075LVX8
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS05415
gene id: 1343739:PAP_RS05415
uniprot id: A0A075LT56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1343739:PAP RS02905
gene id: 1343739:PAP_RS02905
uniprot id: A0A075LWT3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS07075
gene id: 1343739:PAP_RS07075
uniprot id: A0A075LZ37
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS04125
gene id: 1343739:PAP_RS04125
uniprot id: A0A075LXH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1343739:PAP RS09910
gene id: 1343739:PAP_RS09910
uniprot id: A0A075LWH1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1343739:PAP RS01435
gene id: 1343739:PAP_RS01435
uniprot id: A0A075LW80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Cytoplasm
messages: Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG).

1343739:PAP RS00545
gene id: 1343739:PAP_RS00545
uniprot id: A0A075LVR0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1343739:PAP RS04935
gene id: 1343739:PAP_RS04935
uniprot id: A0A075LSW9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1343739:PAP RS07810
gene id: 1343739:PAP_RS07810
uniprot id: A0A075LUD7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

1343739:PAP RS00130
gene id: 1343739:PAP_RS00130
uniprot id: A0A075LVH4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS08900
gene id: 1343739:PAP_RS08900
uniprot id: A0A075LW07
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS03995
gene id: 1343739:PAP_RS03995
uniprot id: A0A075LXD7
names: Similarity
messages: Belongs to the HypE family.

1343739:PAP RS04255
gene id: 1343739:PAP_RS04255
uniprot id: A0A075LSK2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS01530
gene id: 1343739:PAP_RS01530
uniprot id: A0A075LS28
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1343739:PAP RS01850
gene id: 1343739:PAP_RS01850
uniprot id: A0A075LWC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

1343739:PAP RS09215
gene id: 1343739:PAP_RS09215
uniprot id: A0A075LVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1343739:PAP RS01730
gene id: 1343739:PAP_RS01730
uniprot id: A0A075LRP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1343739:PAP RS05305
gene id: 1343739:PAP_RS05305
uniprot id: A0A075LU39
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1343739:PAP RS04665
gene id: 1343739:PAP_RS04665
uniprot id: A0A075LSR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS02745
gene id: 1343739:PAP_RS02745
uniprot id: A0A075LSN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1343739:PAP RS05075
gene id: 1343739:PAP_RS05075
uniprot id: A0A075LTI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS01755
gene id: 1343739:PAP_RS01755
uniprot id: A0A075LRQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS03625
gene id: 1343739:PAP_RS03625
uniprot id: A0A075LT80
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02710
gene id: 1343739:PAP_RS02710
uniprot id: A0A075LS54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1343739:PAP RS09700
gene id: 1343739:PAP_RS09700
uniprot id: A0A075LUF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05595
gene id: 1343739:PAP_RS05595
uniprot id: A0A075LRY7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS09315
gene id: 1343739:PAP_RS09315
uniprot id: A0A075LVS3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1343739:PAP RS09650
gene id: 1343739:PAP_RS09650
uniprot id: A0A075LUE7
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS03510
gene id: 1343739:PAP_RS03510
uniprot id: A0A075LX51
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1343739:PAP RS02520
gene id: 1343739:PAP_RS02520
uniprot id: A0A075LWM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS04020
gene id: 1343739:PAP_RS04020
uniprot id: A0A075LXE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1343739:PAP RS01970
gene id: 1343739:PAP_RS01970
uniprot id: A0A075LWD6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1343739:PAP RS05295
gene id: 1343739:PAP_RS05295
uniprot id: A0A075LRT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

1343739:PAP RS05180
gene id: 1343739:PAP_RS05180
uniprot id: A0A075LXZ5
names: Similarity
messages: Belongs to the UPF0310 family.

1343739:PAP RS02950
gene id: 1343739:PAP_RS02950
uniprot id: A0A075LSS7
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1343739:PAP RS05400
gene id: 1343739:PAP_RS05400
uniprot id: A0A075LTQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

1343739:PAP RS09380
gene id: 1343739:PAP_RS09380
uniprot id: A0A075LVC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS05920
gene id: 1343739:PAP_RS05920
uniprot id: A0A075LU16
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1343739:PAP RS08180
gene id: 1343739:PAP_RS08180
uniprot id: A0A075LV88
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1343739:PAP RS05170
gene id: 1343739:PAP_RS05170
uniprot id: A0A075LTL2
names: Similarity
messages: Belongs to the HsdR family.

1343739:PAP RS03935
gene id: 1343739:PAP_RS03935
uniprot id: A0A075LSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1343739:PAP RS02515
gene id: 1343739:PAP_RS02515
uniprot id: A0A075LSJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

1343739:PAP RS07030
gene id: 1343739:PAP_RS07030
uniprot id: A0A075LZ25
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1343739:PAP RS08920
gene id: 1343739:PAP_RS08920
uniprot id: A0A075LVN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1343739:PAP RS09225
gene id: 1343739:PAP_RS09225
uniprot id: A0A075M0E7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1343739:PAP RS00610
gene id: 1343739:PAP_RS00610
uniprot id: A0A075LPE3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1343739:PAP RS00530
gene id: 1343739:PAP_RS00530
uniprot id: A0A075LPC4
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

1343739:PAP RS00805
gene id: 1343739:PAP_RS00805
uniprot id: A0A075LVZ5
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS04275
gene id: 1343739:PAP_RS04275
uniprot id: A0A075LXJ5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS07565
gene id: 1343739:PAP_RS07565
uniprot id: A0A075LT44
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1343739:PAP RS07115
gene id: 1343739:PAP_RS07115
uniprot id: A0A075LUM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

1343739:PAP RS09400
gene id: 1343739:PAP_RS09400
uniprot id: A0A075M0I9
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1343739:PAP RS02680
gene id: 1343739:PAP_RS02680
uniprot id: A0A075LQH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS09780
gene id: 1343739:PAP_RS09780
uniprot id: A0A075LWF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS05380
gene id: 1343739:PAP_RS05380
uniprot id: A0A075LTP6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1343739:PAP RS06610
gene id: 1343739:PAP_RS06610
uniprot id: A0A075LSL0
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1343739:PAP RS01000
gene id: 1343739:PAP_RS01000
uniprot id: A0A075LRU0
names: Similarity
messages: Belongs to the MoaD family.

1343739:PAP RS06595
gene id: 1343739:PAP_RS06595
uniprot id: A0A075LUR2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1343739:PAP RS09010
gene id: 1343739:PAP_RS09010
uniprot id: A0A075LW21
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

1343739:PAP RS06370
gene id: 1343739:PAP_RS06370
uniprot id: A0A075LU75
names: Similarity
messages: Belongs to the UPF0251 family.

1343739:PAP RS04360
gene id: 1343739:PAP_RS04360
uniprot id: A0A075LXL2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1343739:PAP RS02310
gene id: 1343739:PAP_RS02310
uniprot id: A0A075LQB4
names: Similarity
messages: Belongs to the UPF0292 family.

1343739:PAP RS04820
gene id: 1343739:PAP_RS04820
uniprot id: A0A075LTD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

1343739:PAP RS03955
gene id: 1343739:PAP_RS03955
uniprot id: A0A075LR59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1343739:PAP RS08715
gene id: 1343739:PAP_RS08715
uniprot id: A0A075LTW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

1343739:PAP RS08185
gene id: 1343739:PAP_RS08185
uniprot id: A0A075LVL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

1343739:PAP RS02810
gene id: 1343739:PAP_RS02810
uniprot id: A0A075LQJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

1343739:PAP RS09430
gene id: 1343739:PAP_RS09430
uniprot id: A0A075LVD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1343739:PAP RS07940
gene id: 1343739:PAP_RS07940
uniprot id: A0A075LUG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1343739:PAP RS10225
gene id: 1343739:PAP_RS10225
uniprot id: A0A075LU80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS10050
gene id: 1343739:PAP_RS10050
uniprot id: A0A075LUL9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1343739:PAP RS02540
gene id: 1343739:PAP_RS02540
uniprot id: A0A075LSJ6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1343739:PAP RS03490
gene id: 1343739:PAP_RS03490
uniprot id: A0A075LS68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1343739:PAP RS08585
gene id: 1343739:PAP_RS08585
uniprot id: A0A075LUY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS03770
gene id: 1343739:PAP_RS03770
uniprot id: A0A075LR31
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS07510
gene id: 1343739:PAP_RS07510
uniprot id: A0A075LV99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01495
gene id: 1343739:PAP_RS01495
uniprot id: A0A075LPX4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1343739:PAP RS03660
gene id: 1343739:PAP_RS03660
uniprot id: A0A075LS99
names: Similarity
messages: Belongs to the UPF0107 family.

1343739:PAP RS06505
gene id: 1343739:PAP_RS06505
uniprot id: A0A075LTM9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00690
gene id: 1343739:PAP_RS00690
uniprot id: A0A075LR72
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1343739:PAP RS08110
gene id: 1343739:PAP_RS08110
uniprot id: A0A075LUJ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS04670
gene id: 1343739:PAP_RS04670
uniprot id: A0A075LRI9
names: Similarity
messages: Belongs to the PDCD5 family.

1343739:PAP RS07670
gene id: 1343739:PAP_RS07670
uniprot id: A0A075LUZ9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07745
gene id: 1343739:PAP_RS07745
uniprot id: A0A075LV12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS03495
gene id: 1343739:PAP_RS03495
uniprot id: A0A075LQY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1343739:PAP RS05790
gene id: 1343739:PAP_RS05790
uniprot id: A0A075LTD1
names: Similarity
messages: Belongs to the UPF0147 family.

1343739:PAP RS09595
gene id: 1343739:PAP_RS09595
uniprot id: A0A075LVG6
names: Similarity
messages: Belongs to the intimin/invasin family.

1343739:PAP RS02115
gene id: 1343739:PAP_RS02115
uniprot id: A0A075LSC5
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01740
gene id: 1343739:PAP_RS01740
uniprot id: A0A075LWB4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1343739:PAP RS06670
gene id: 1343739:PAP_RS06670
uniprot id: A0A075LUS6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS07715
gene id: 1343739:PAP_RS07715
uniprot id: A0A075LT74
names: Similarity
messages: Belongs to the GbsR family.

1343739:PAP RS06270
gene id: 1343739:PAP_RS06270
uniprot id: A0A075LSE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS09695
gene id: 1343739:PAP_RS09695
uniprot id: A0A075LVI6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

1343739:PAP RS02685
gene id: 1343739:PAP_RS02685
uniprot id: A0A075LS50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1343739:PAP RS09170
gene id: 1343739:PAP_RS09170
uniprot id: A0A075LV85
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1343739:PAP RS09545
gene id: 1343739:PAP_RS09545
uniprot id: A0A075M0M2
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1343739:PAP RS02220
gene id: 1343739:PAP_RS02220
uniprot id: A0A075LRC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1343739:PAP RS06705
gene id: 1343739:PAP_RS06705
uniprot id: A0A075LTR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1343739:PAP RS04565
gene id: 1343739:PAP_RS04565
uniprot id: A0A075LSQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1343739:PAP RS07065
gene id: 1343739:PAP_RS07065
uniprot id: A0A075LUL0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01385
gene id: 1343739:PAP_RS01385
uniprot id: A0A075LW77
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1343739:PAP RS09025
gene id: 1343739:PAP_RS09025
uniprot id: A0A075LU27
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1343739:PAP RS05730
gene id: 1343739:PAP_RS05730
uniprot id: A0A075LUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1343739:PAP RS07820
gene id: 1343739:PAP_RS07820
uniprot id: A0A075LV24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS07710
gene id: 1343739:PAP_RS07710
uniprot id: A0A075LUB9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00850
gene id: 1343739:PAP_RS00850
uniprot id: A0A075LRP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1343739:PAP RS03405
gene id: 1343739:PAP_RS03405
uniprot id: A0A075LT43
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1343739:PAP RS02880
gene id: 1343739:PAP_RS02880
uniprot id: A0A075LWS9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01075
gene id: 1343739:PAP_RS01075
uniprot id: A0A075LRV2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

1343739:PAP RS06025
gene id: 1343739:PAP_RS06025
uniprot id: A0A075LYG6
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

1343739:PAP RS03655
gene id: 1343739:PAP_RS03655
uniprot id: A0A075LX71
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS04950
gene id: 1343739:PAP_RS04950
uniprot id: A0A075LTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS06920
gene id: 1343739:PAP_RS06920
uniprot id: A0A075LUY0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1343739:PAP RS01725
gene id: 1343739:PAP_RS01725
uniprot id: A0A075LQ16
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1343739:PAP RS04545
gene id: 1343739:PAP_RS04545
uniprot id: A0A075LRG6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

1343739:PAP RS04515
gene id: 1343739:PAP_RS04515
uniprot id: A0A075LXN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1343739:PAP RS04910
gene id: 1343739:PAP_RS04910
uniprot id: A0A075LSW4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1343739:PAP RS04480
gene id: 1343739:PAP_RS04480
uniprot id: A0A075LT67
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1343739:PAP RS04220
gene id: 1343739:PAP_RS04220
uniprot id: A0A075LT17
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS06790
gene id: 1343739:PAP_RS06790
uniprot id: A0A075LUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1343739:PAP RS03890
gene id: 1343739:PAP_RS03890
uniprot id: A0A075LTC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1343739:PAP RS07870
gene id: 1343739:PAP_RS07870
uniprot id: A0A075LTA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS01800
gene id: 1343739:PAP_RS01800
uniprot id: A0A075LQ29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS06220
gene id: 1343739:PAP_RS06220
uniprot id: A0A075LU47
names: Similarity
messages: Belongs to the HupF/HypC family.

1343739:PAP RS01735
gene id: 1343739:PAP_RS01735
uniprot id: A0A075LS62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS01260
gene id: 1343739:PAP_RS01260
uniprot id: A0A075LQX0
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00025
gene id: 1343739:PAP_RS00025
uniprot id: A0A075LR52
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

1343739:PAP RS09005
gene id: 1343739:PAP_RS09005
uniprot id: A0A075LVP2
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00555
gene id: 1343739:PAP_RS00555
uniprot id: A0A075LPD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1343739:PAP RS03145
gene id: 1343739:PAP_RS03145
uniprot id: A0A075LSF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1343739:PAP RS07475
gene id: 1343739:PAP_RS07475
uniprot id: A0A075LT24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1343739:PAP RS09455
gene id: 1343739:PAP_RS09455
uniprot id: A0A075LVD6
names: Similarity
messages: Belongs to the UPF0047 family.

1343739:PAP RS03135
gene id: 1343739:PAP_RS03135
uniprot id: A0A075LRV3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1343739:PAP RS06950
gene id: 1343739:PAP_RS06950
uniprot id: A0A075LZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

1343739:PAP RS09800
gene id: 1343739:PAP_RS09800
uniprot id: A0A075LWF6
names: Similarity
messages: Belongs to the carbamate kinase family.

1343739:PAP RS05870
gene id: 1343739:PAP_RS05870
uniprot id: A0A075LS74
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1343739:PAP RS00590
gene id: 1343739:PAP_RS00590
uniprot id: A0A075LRG5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS04225
gene id: 1343739:PAP_RS04225
uniprot id: A0A075LTH9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02800
gene id: 1343739:PAP_RS02800
uniprot id: A0A075LWR3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

1343739:PAP RS08045
gene id: 1343739:PAP_RS08045
uniprot id: A0A075LV57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS04770
gene id: 1343739:PAP_RS04770
uniprot id: A0A075LTC4
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1343739:PAP RS02630
gene id: 1343739:PAP_RS02630
uniprot id: A0A075LQH3
names: Similarity
messages: Belongs to the HypE family.

1343739:PAP RS08050
gene id: 1343739:PAP_RS08050
uniprot id: A0A075LVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS03415
gene id: 1343739:PAP_RS03415
uniprot id: A0A075LS57
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

1343739:PAP RS00820
gene id: 1343739:PAP_RS00820
uniprot id: A0A075LRA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1343739:PAP RS05435
gene id: 1343739:PAP_RS05435
uniprot id: A0A075LU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS00180
gene id: 1343739:PAP_RS00180
uniprot id: A0A075LVI4
names: Subcellular Location Annotation
messages: Cytoplasm

1343739:PAP RS07015
gene id: 1343739:PAP_RS07015
uniprot id: A0A075LST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1343739:PAP RS04265
gene id: 1343739:PAP_RS04265
uniprot id: A0A075LT26
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS02975
gene id: 1343739:PAP_RS02975
uniprot id: A0A075LST4
names: Similarity
messages: Belongs to the UPF0248 family.

1343739:PAP RS09200
gene id: 1343739:PAP_RS09200
uniprot id: A0A075M0E1
names: Function
messages: Part of a potassium transport system.

1343739:PAP RS07530
gene id: 1343739:PAP_RS07530
uniprot id: A0A075LVA1
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS09655
gene id: 1343739:PAP_RS09655
uniprot id: A0A075LVX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1343739:PAP RS00790
gene id: 1343739:PAP_RS00790
uniprot id: A0A075LPL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1343739:PAP RS02555
gene id: 1343739:PAP_RS02555
uniprot id: A0A075LQF5
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09330
gene id: 1343739:PAP_RS09330
uniprot id: A0A075M0H0
names: Similarity
messages: Belongs to the threonine synthase family.

1343739:PAP RS04140
gene id: 1343739:PAP_RS04140
uniprot id: A0A075LR87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

1343739:PAP RS04775
gene id: 1343739:PAP_RS04775
uniprot id: A0A075LTR7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1343739:PAP RS06815
gene id: 1343739:PAP_RS06815
uniprot id: A0A075LYY4
names: Subunit
messages: Homodimer.

1343739:PAP RS00675
gene id: 1343739:PAP_RS00675
uniprot id: A0A075LVT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1343739:PAP RS05115
gene id: 1343739:PAP_RS05115
uniprot id: A0A075LT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS01820
gene id: 1343739:PAP_RS01820
uniprot id: A0A075LQ32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS09190
gene id: 1343739:PAP_RS09190
uniprot id: A0A075LVR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1343739:PAP RS04810
gene id: 1343739:PAP_RS04810
uniprot id: A0A075LSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

1343739:PAP RS00480
gene id: 1343739:PAP_RS00480
uniprot id: A0A075LR15
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1343739:PAP RS02270
gene id: 1343739:PAP_RS02270
uniprot id: A0A075LSE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1343739:PAP RS02670
gene id: 1343739:PAP_RS02670
uniprot id: A0A075LWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS08270
gene id: 1343739:PAP_RS08270
uniprot id: A0A075LVN2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1343739:PAP RS09535
gene id: 1343739:PAP_RS09535
uniprot id: A0A075LVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1343739:PAP RS03245
gene id: 1343739:PAP_RS03245
uniprot id: A0A075LQS4
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1343739:PAP RS09270
gene id: 1343739:PAP_RS09270
uniprot id: A0A075LW62
names: Similarity
messages: Belongs to the UPF0282 family.

1343739:PAP RS00930
gene id: 1343739:PAP_RS00930
uniprot id: A0A075LW12
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS09375
gene id: 1343739:PAP_RS09375
uniprot id: A0A075M0I1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1343739:PAP RS00780
gene id: 1343739:PAP_RS00780
uniprot id: A0A075LVY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1343739:PAP RS01165
gene id: 1343739:PAP_RS01165
uniprot id: A0A075LPS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS02690
gene id: 1343739:PAP_RS02690
uniprot id: A0A075LSM4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

1343739:PAP RS09395
gene id: 1343739:PAP_RS09395
uniprot id: A0A075LW83
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1343739:PAP RS07550
gene id: 1343739:PAP_RS07550
uniprot id: A0A075LVA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1343739:PAP RS07055
gene id: 1343739:PAP_RS07055
uniprot id: A0A075LZ31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1343739:PAP RS03610
gene id: 1343739:PAP_RS03610
uniprot id: A0A075LS90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1343739:PAP RS02230
gene id: 1343739:PAP_RS02230
uniprot id: A0A075LRY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1343739:PAP RS02320
gene id: 1343739:PAP_RS02320
uniprot id: A0A075LWJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1343739:PAP RS05300
gene id: 1343739:PAP_RS05300
uniprot id: A0A075LTN0
names: Similarity
messages: Belongs to the UPF0179 family.

1343739:PAP RS08885
gene id: 1343739:PAP_RS08885
uniprot id: A0A075LV51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1343739:PAP RS02035
gene id: 1343739:PAP_RS02035
uniprot id: A0A075LRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1343739:PAP RS04695
gene id: 1343739:PAP_RS04695
uniprot id: A0A075LRJ3
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1343739:PAP RS03500
gene id: 1343739:PAP_RS03500
uniprot id: A0A075LSQ7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1343739:PAP RS06140
gene id: 1343739:PAP_RS06140
uniprot id: A0A075LSC6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1343739:PAP RS06895
gene id: 1343739:PAP_RS06895
uniprot id: A0A075LUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1343739:PAP RS01190
gene id: 1343739:PAP_RS01190
uniprot id: A0A075LPS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS09220
gene id: 1343739:PAP_RS09220
uniprot id: A0A075LW53
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01865
gene id: 1343739:PAP_RS01865
uniprot id: A0A075LRS0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1343739:PAP RS05375
gene id: 1343739:PAP_RS05375
uniprot id: A0A075LRV4
names: Subcellular Location Annotation
messages: Nucleus

1343739:PAP RS07685
gene id: 1343739:PAP_RS07685
uniprot id: A0A075LUB2
names: Similarity
messages: Belongs to the glutaredoxin family.

1343739:PAP RS09475
gene id: 1343739:PAP_RS09475
uniprot id: A0A075M0K5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1343739:PAP RS03815
gene id: 1343739:PAP_RS03815
uniprot id: A0A075LXA1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1343739:PAP RS01100
gene id: 1343739:PAP_RS01100
uniprot id: A0A075LRV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS06180
gene id: 1343739:PAP_RS06180
uniprot id: A0A075LYJ6
names: Similarity
messages: Belongs to the UPF0045 family.

1343739:PAP RS03580
gene id: 1343739:PAP_RS03580
uniprot id: A0A075LX60
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01840
gene id: 1343739:PAP_RS01840
uniprot id: A0A075LRR6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

1343739:PAP RS00625
gene id: 1343739:PAP_RS00625
uniprot id: A0A075LVS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1343739:PAP RS03070
gene id: 1343739:PAP_RS03070
uniprot id: A0A075LSD2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1343739:PAP RS00695
gene id: 1343739:PAP_RS00695
uniprot id: A0A075LRK8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1343739:PAP RS05190
gene id: 1343739:PAP_RS05190
uniprot id: A0A075LT15
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

1343739:PAP RS00165
gene id: 1343739:PAP_RS00165
uniprot id: A0A075LP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS07965
gene id: 1343739:PAP_RS07965
uniprot id: A0A075LUG4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01990
gene id: 1343739:PAP_RS01990
uniprot id: A0A075LSA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1343739:PAP RS00800
gene id: 1343739:PAP_RS00800
uniprot id: A0A075LRN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1343739:PAP RS03980
gene id: 1343739:PAP_RS03980
uniprot id: A0A075LR63
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02700
gene id: 1343739:PAP_RS02700
uniprot id: A0A075LRK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1343739:PAP RS08410
gene id: 1343739:PAP_RS08410
uniprot id: A0A075LVT7
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS04260
gene id: 1343739:PAP_RS04260
uniprot id: A0A075LRB1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS00825
gene id: 1343739:PAP_RS00825
uniprot id: A0A075LRP4
names: Similarity
messages: Belongs to the peptidase S9C family.

1343739:PAP RS07035
gene id: 1343739:PAP_RS07035
uniprot id: A0A075LTW8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1343739:PAP RS05570
gene id: 1343739:PAP_RS05570
uniprot id: A0A075LTS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS04795
gene id: 1343739:PAP_RS04795
uniprot id: A0A075LTC9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1343739:PAP RS00320
gene id: 1343739:PAP_RS00320
uniprot id: A0A075LP88
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1343739:PAP RS04945
gene id: 1343739:PAP_RS04945
uniprot id: A0A075LTF5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1343739:PAP RS03795
gene id: 1343739:PAP_RS03795
uniprot id: A0A075LSC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1343739:PAP RS02765
gene id: 1343739:PAP_RS02765
uniprot id: A0A075LS64
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1343739:PAP RS01445
gene id: 1343739:PAP_RS01445
uniprot id: A0A075LPW7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1343739:PAP RS07850
gene id: 1343739:PAP_RS07850
uniprot id: A0A075LVF3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1343739:PAP RS01875
gene id: 1343739:PAP_RS01875
uniprot id: A0A075LS86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1343739:PAP RS04700
gene id: 1343739:PAP_RS04700
uniprot id: A0A075LTA8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

1343739:PAP RS04640
gene id: 1343739:PAP_RS04640
uniprot id: A0A075LSR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1343739:PAP RS06215
gene id: 1343739:PAP_RS06215
uniprot id: A0A075LSD9
names: Similarity
messages: Belongs to the HypD family.

1343739:PAP RS00865
gene id: 1343739:PAP_RS00865
uniprot id: A0A075LPN0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1343739:PAP RS06765
gene id: 1343739:PAP_RS06765
uniprot id: A0A075LUU8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1343739:PAP RS01600
gene id: 1343739:PAP_RS01600
uniprot id: A0A075LPZ1
names: Similarity
messages: Belongs to the UPF0215 family.

1343739:PAP RS00195
gene id: 1343739:PAP_RS00195
uniprot id: A0A075LQT5
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

1343739:PAP RS02060
gene id: 1343739:PAP_RS02060
uniprot id: A0A075LRV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1343739:PAP RS03755
gene id: 1343739:PAP_RS03755
uniprot id: A0A075LTA0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1343739:PAP RS00310
gene id: 1343739:PAP_RS00310
uniprot id: A0A075LVL1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1343739:PAP RS04630
gene id: 1343739:PAP_RS04630
uniprot id: A0A075LTP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1343739:PAP RS07690
gene id: 1343739:PAP_RS07690
uniprot id: A0A075LT68
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS03830
gene id: 1343739:PAP_RS03830
uniprot id: A0A075LSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1343739:PAP RS01275
gene id: 1343739:PAP_RS01275
uniprot id: A0A075LRY6
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

1343739:PAP RS03085
gene id: 1343739:PAP_RS03085
uniprot id: A0A075LRT9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

1343739:PAP RS03700
gene id: 1343739:PAP_RS03700
uniprot id: A0A075LSU2
names: Subcellular Location Annotation
messages: Cytoplasm

1343739:PAP RS09495
gene id: 1343739:PAP_RS09495
uniprot id: A0A075M0L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

1343739:PAP RS06050
gene id: 1343739:PAP_RS06050
uniprot id: A0A075LYH1
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS03880
gene id: 1343739:PAP_RS03880
uniprot id: A0A075LR46
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01125
gene id: 1343739:PAP_RS01125
uniprot id: A0A075LRV9
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS05250
gene id: 1343739:PAP_RS05250
uniprot id: A0A075LRT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1343739:PAP RS08930
gene id: 1343739:PAP_RS08930
uniprot id: A0A075M079
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01585
gene id: 1343739:PAP_RS01585
uniprot id: A0A075LS37
names: Similarity
messages: Belongs to the acylphosphatase family.

1343739:PAP RS03645
gene id: 1343739:PAP_RS03645
uniprot id: A0A075LST2
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07525
gene id: 1343739:PAP_RS07525
uniprot id: A0A075LUW2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1343739:PAP RS02355
gene id: 1343739:PAP_RS02355
uniprot id: A0A075LQC2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS01225
gene id: 1343739:PAP_RS01225
uniprot id: A0A075LRX6
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS06730
gene id: 1343739:PAP_RS06730
uniprot id: A0A075LTR5
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1343739:PAP RS09240
gene id: 1343739:PAP_RS09240
uniprot id: A0A075LVR5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1343739:PAP RS00665
gene id: 1343739:PAP_RS00665
uniprot id: A0A075LR50
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1343739:PAP RS02940
gene id: 1343739:PAP_RS02940
uniprot id: A0A075LQL1
names: Similarity
messages: Belongs to the peptidase S49 family.

1343739:PAP RS05525
gene id: 1343739:PAP_RS05525
uniprot id: A0A075LY54
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07535
gene id: 1343739:PAP_RS07535
uniprot id: A0A075LU79
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1343739:PAP RS09040
gene id: 1343739:PAP_RS09040
uniprot id: A0A075M0A3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

1343739:PAP RS01130
gene id: 1343739:PAP_RS01130
uniprot id: A0A075LW44
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS07050
gene id: 1343739:PAP_RS07050
uniprot id: A0A075LV06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1343739:PAP RS02070
gene id: 1343739:PAP_RS02070
uniprot id: A0A075LWF0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1343739:PAP RS01095
gene id: 1343739:PAP_RS01095
uniprot id: A0A075LRE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS00235
gene id: 1343739:PAP_RS00235
uniprot id: A0A075LVJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1343739:PAP RS08055
gene id: 1343739:PAP_RS08055
uniprot id: A0A075LZM0
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS08850
gene id: 1343739:PAP_RS08850
uniprot id: A0A075LVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1343739:PAP RS01965
gene id: 1343739:PAP_RS01965
uniprot id: A0A075LSA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1343739:PAP RS01420
gene id: 1343739:PAP_RS01420
uniprot id: A0A075LPW3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

1343739:PAP RS07785
gene id: 1343739:PAP_RS07785
uniprot id: A0A075LUD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1343739:PAP RS03180
gene id: 1343739:PAP_RS03180
uniprot id: A0A075LSX0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1343739:PAP RS06200
gene id: 1343739:PAP_RS06200
uniprot id: A0A075LUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

1343739:PAP RS02885
gene id: 1343739:PAP_RS02885
uniprot id: A0A075LRP7
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

1343739:PAP RS05755
gene id: 1343739:PAP_RS05755
uniprot id: A0A075LUA9
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

1343739:PAP RS06800
gene id: 1343739:PAP_RS06800
uniprot id: A0A075LSP4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1343739:PAP RS02235
gene id: 1343739:PAP_RS02235
uniprot id: A0A075LSE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1343739:PAP RS04190
gene id: 1343739:PAP_RS04190
uniprot id: A0A075LR96
names: Similarity
messages: Belongs to the IMPACT family.

1343739:PAP RS01590
gene id: 1343739:PAP_RS01590
uniprot id: A0A075LW99
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1343739:PAP RS06205
gene id: 1343739:PAP_RS06205
uniprot id: A0A075LYK0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1343739:PAP RS02055
gene id: 1343739:PAP_RS02055
uniprot id: A0A075LQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1343739:PAP RS02065
gene id: 1343739:PAP_RS02065
uniprot id: A0A075LSB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

1343739:PAP RS00425
gene id: 1343739:PAP_RS00425
uniprot id: A0A075LPA4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS04875
gene id: 1343739:PAP_RS04875
uniprot id: A0A075LTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1343739:PAP RS07250
gene id: 1343739:PAP_RS07250
uniprot id: A0A075LUP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1343739:PAP RS07720
gene id: 1343739:PAP_RS07720
uniprot id: A0A075LV08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1343739:PAP RS08875
gene id: 1343739:PAP_RS08875
uniprot id: A0A075LW03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1343739:PAP RS04975
gene id: 1343739:PAP_RS04975
uniprot id: A0A075LTX3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1343739:PAP RS04955
gene id: 1343739:PAP_RS04955
uniprot id: A0A075LXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS05795
gene id: 1343739:PAP_RS05795
uniprot id: A0A075LS29
names: Subunit
messages: Homotetramer.

1343739:PAP RS02255
gene id: 1343739:PAP_RS02255
uniprot id: A0A075LQP1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01785
gene id: 1343739:PAP_RS01785
uniprot id: A0A075LS70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1343739:PAP RS04760
gene id: 1343739:PAP_RS04760
uniprot id: A0A075LST5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1343739:PAP RS05865
gene id: 1343739:PAP_RS05865
uniprot id: A0A075LTF2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1343739:PAP RS00225
gene id: 1343739:PAP_RS00225
uniprot id: A0A075LQT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1343739:PAP RS01950
gene id: 1343739:PAP_RS01950
uniprot id: A0A075LR73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1343739:PAP RS04455
gene id: 1343739:PAP_RS04455
uniprot id: A0A075LT63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1343739:PAP RS02890
gene id: 1343739:PAP_RS02890
uniprot id: A0A075LQK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS06940
gene id: 1343739:PAP_RS06940
uniprot id: A0A075LUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1343739:PAP RS05690
gene id: 1343739:PAP_RS05690
uniprot id: A0A075LTB4
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

1343739:PAP RS03305
gene id: 1343739:PAP_RS03305
uniprot id: A0A075LT21
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1343739:PAP RS01640
gene id: 1343739:PAP_RS01640
uniprot id: A0A075LWA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

1343739:PAP RS04645
gene id: 1343739:PAP_RS04645
uniprot id: A0A075LRI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1343739:PAP RS05905
gene id: 1343739:PAP_RS05905
uniprot id: A0A075LUE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1343739:PAP RS01110
gene id: 1343739:PAP_RS01110
uniprot id: A0A075LQU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1343739:PAP RS02440
gene id: 1343739:PAP_RS02440
uniprot id: A0A075LSH4
names: Similarity
messages: Belongs to the peptidase U62 family.

1343739:PAP RS02545
gene id: 1343739:PAP_RS02545
uniprot id: A0A075LWM5
names: Similarity
messages: Belongs to the thymidylate kinase family.

1343739:PAP RS01705
gene id: 1343739:PAP_RS01705
uniprot id: A0A075LRP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1343739:PAP RS09760
gene id: 1343739:PAP_RS09760
uniprot id: A0A075M0R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1343739:PAP RS09765
gene id: 1343739:PAP_RS09765
uniprot id: A0A075LVK2
names: Similarity
messages: Belongs to the AOR/FOR family.

1343739:PAP RS09195
gene id: 1343739:PAP_RS09195
uniprot id: A0A075LW49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1343739:PAP RS00615
gene id: 1343739:PAP_RS00615
uniprot id: A0A075LR38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

1343739:PAP RS05080
gene id: 1343739:PAP_RS05080
uniprot id: A0A075LTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS09500
gene id: 1343739:PAP_RS09500
uniprot id: A0A075LVE4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1343739:PAP RS09045
gene id: 1343739:PAP_RS09045
uniprot id: A0A075LV73
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

1343739:PAP RS09340
gene id: 1343739:PAP_RS09340
uniprot id: A0A075LU87
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1343739:PAP RS06770
gene id: 1343739:PAP_RS06770
uniprot id: A0A075LYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1343739:PAP RS04985
gene id: 1343739:PAP_RS04985
uniprot id: A0A075LSY1
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00650
gene id: 1343739:PAP_RS00650
uniprot id: A0A075LVS6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1343739:PAP RS04045
gene id: 1343739:PAP_RS04045
uniprot id: A0A075LTE8
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS00205
gene id: 1343739:PAP_RS00205
uniprot id: A0A075LVJ0
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01810
gene id: 1343739:PAP_RS01810
uniprot id: A0A075LRR2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1343739:PAP RS02430
gene id: 1343739:PAP_RS02430
uniprot id: A0A075LQD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1343739:PAP RS07095
gene id: 1343739:PAP_RS07095
uniprot id: A0A075LV15
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1343739:PAP RS04705
gene id: 1343739:PAP_RS04705
uniprot id: A0A075LTQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1343739:PAP RS06785
gene id: 1343739:PAP_RS06785
uniprot id: A0A075LUF5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1343739:PAP RS04290
gene id: 1343739:PAP_RS04290
uniprot id: A0A075LT32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1343739:PAP RS08745
gene id: 1343739:PAP_RS08745
uniprot id: A0A075LVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

1343739:PAP RS00305
gene id: 1343739:PAP_RS00305
uniprot id: A0A075LRA3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1343739:PAP RS05940
gene id: 1343739:PAP_RS05940
uniprot id: A0A075LS89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1343739:PAP RS02720
gene id: 1343739:PAP_RS02720
uniprot id: A0A075LWQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1343739:PAP RS06275
gene id: 1343739:PAP_RS06275
uniprot id: A0A075LU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1343739:PAP RS10040
gene id: 1343739:PAP_RS10040
uniprot id: A0A075M0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1343739:PAP RS04650
gene id: 1343739:PAP_RS04650
uniprot id: A0A075LT96
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1343739:PAP RS07570
gene id: 1343739:PAP_RS07570
uniprot id: A0A075LUX5
names: Similarity
messages: Belongs to the HerA family.

1343739:PAP RS09935
gene id: 1343739:PAP_RS09935
uniprot id: A0A075LWH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1343739:PAP RS01770
gene id: 1343739:PAP_RS01770
uniprot id: A0A075LR48
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1343739:PAP RS03885
gene id: 1343739:PAP_RS03885
uniprot id: A0A075LSX7
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS02930
gene id: 1343739:PAP_RS02930
uniprot id: A0A075LWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1343739:PAP RS01195
gene id: 1343739:PAP_RS01195
uniprot id: A0A075LRG3
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS08240
gene id: 1343739:PAP_RS08240
uniprot id: A0A075LV94
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1343739:PAP RS02045
gene id: 1343739:PAP_RS02045
uniprot id: A0A075LWE6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1343739:PAP RS09985
gene id: 1343739:PAP_RS09985
uniprot id: A0A075LWI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1343739:PAP RS06795
gene id: 1343739:PAP_RS06795
uniprot id: A0A075LTS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1343739:PAP RS06335
gene id: 1343739:PAP_RS06335
uniprot id: A0A075LYM4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1343739:PAP RS03250
gene id: 1343739:PAP_RS03250
uniprot id: A0A075LSY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1343739:PAP RS00015
gene id: 1343739:PAP_RS00015
uniprot id: A0A075LP21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1343739:PAP RS01655
gene id: 1343739:PAP_RS01655
uniprot id: A0A075LRN1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1343739:PAP RS02390
gene id: 1343739:PAP_RS02390
uniprot id: A0A075LSG7
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

1343739:PAP RS05810
gene id: 1343739:PAP_RS05810
uniprot id: A0A075LYA6
names: Similarity
messages: Belongs to the class-I fumarase family.

1343739:PAP RS04755
gene id: 1343739:PAP_RS04755
uniprot id: A0A075LXS9
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1343739:PAP RS00755
gene id: 1343739:PAP_RS00755
uniprot id: A0A075LVY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1343739:PAP RS00080
gene id: 1343739:PAP_RS00080
uniprot id: A0A075LQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1343739:PAP RS03000
gene id: 1343739:PAP_RS03000
uniprot id: A0A075LSU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

1343739:PAP RS01535
gene id: 1343739:PAP_RS01535
uniprot id: A0A075LW93
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

1343739:PAP RS05455
gene id: 1343739:PAP_RS05455
uniprot id: A0A075LTQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

1343739:PAP RS02995
gene id: 1343739:PAP_RS02995
uniprot id: A0A075LSB2
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1343739:PAP RS05805
gene id: 1343739:PAP_RS05805
uniprot id: A0A075LUB8
names: Similarity
messages: Belongs to the class-I fumarase family.

1343739:PAP RS07110
gene id: 1343739:PAP_RS07110
uniprot id: A0A075LSV5
names: Similarity
messages: Belongs to the glutaredoxin family.

1343739:PAP RS08135
gene id: 1343739:PAP_RS08135
uniprot id: A0A075LUJ4
names: Subcellular Location Annotation
messages: Membrane

1343739:PAP RS01565
gene id: 1343739:PAP_RS01565
uniprot id: A0A075LW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1343739:PAP RS05915
gene id: 1343739:PAP_RS05915
uniprot id: A0A075LS84
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1343739:PAP RS00520
gene id: 1343739:PAP_RS00520
uniprot id: A0A075LVQ5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1343739:PAP RS05930
gene id: 1343739:PAP_RS05930
uniprot id: A0A075LYE9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1343739:PAP RS01090
gene id: 1343739:PAP_RS01090
uniprot id: A0A075LPR0
names: Similarity
messages: Belongs to the peptidase U62 family.

1343739:PAP RS04105
gene id: 1343739:PAP_RS04105
uniprot id: A0A075LSI4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

1343739:PAP RS01465
gene id: 1343739:PAP_RS01465
uniprot id: A0A075LQZ9
names: Similarity
messages: Belongs to the ZPR1 family.

1343739:PAP RS02570
gene id: 1343739:PAP_RS02570
uniprot id: A0A075LWM8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1343739:PAP RS05610
gene id: 1343739:PAP_RS05610
uniprot id: A0A075LY69
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1343739:PAP RS01560
gene id: 1343739:PAP_RS01560
uniprot id: A0A075LR36
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.