1335757:SPICUR RS02825
gene id: 1335757:SPICUR_RS02825
uniprot id: U5T2R4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1335757:SPICUR RS03045
gene id: 1335757:SPICUR_RS03045
uniprot id: U5T280
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1335757:SPICUR RS02670
gene id: 1335757:SPICUR_RS02670
uniprot id: U5T5D6
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01440
gene id: 1335757:SPICUR_RS01440
uniprot id: U5T225
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS08985
gene id: 1335757:SPICUR_RS08985
uniprot id: U5T5D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1335757:SPICUR RS04085
gene id: 1335757:SPICUR_RS04085
uniprot id: U5T3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

1335757:SPICUR RS04340
gene id: 1335757:SPICUR_RS04340
uniprot id: U5T338
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS09170
gene id: 1335757:SPICUR_RS09170
uniprot id: U5T5H6
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1335757:SPICUR RS06555
gene id: 1335757:SPICUR_RS06555
uniprot id: U5T4T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS09160
gene id: 1335757:SPICUR_RS09160
uniprot id: U5T925
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1335757:SPICUR RS01225
gene id: 1335757:SPICUR_RS01225
uniprot id: U5T1I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

1335757:SPICUR RS07660
gene id: 1335757:SPICUR_RS07660
uniprot id: U5T4N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06115
gene id: 1335757:SPICUR_RS06115
uniprot id: U5T449
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1335757:SPICUR RS02190
gene id: 1335757:SPICUR_RS02190
uniprot id: U5T2F2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

1335757:SPICUR RS05725
gene id: 1335757:SPICUR_RS05725
uniprot id: U5T3Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06595
gene id: 1335757:SPICUR_RS06595
uniprot id: U5T440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS01875
gene id: 1335757:SPICUR_RS01875
uniprot id: U5T297
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1335757:SPICUR RS03070
gene id: 1335757:SPICUR_RS03070
uniprot id: U5T286
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

1335757:SPICUR RS06170
gene id: 1335757:SPICUR_RS06170
uniprot id: U5T4L1
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

1335757:SPICUR RS02400
gene id: 1335757:SPICUR_RS02400
uniprot id: U5T5N8
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

1335757:SPICUR RS02520
gene id: 1335757:SPICUR_RS02520
uniprot id: U5T266
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

1335757:SPICUR RS04900
gene id: 1335757:SPICUR_RS04900
uniprot id: U5T6W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1335757:SPICUR RS01140
gene id: 1335757:SPICUR_RS01140
uniprot id: U5T152
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1335757:SPICUR RS01385
gene id: 1335757:SPICUR_RS01385
uniprot id: U5T1K8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS02645
gene id: 1335757:SPICUR_RS02645
uniprot id: U5T5D0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS03455
gene id: 1335757:SPICUR_RS03455
uniprot id: U5T2E7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS04935
gene id: 1335757:SPICUR_RS04935
uniprot id: U5T352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1335757:SPICUR RS07270
gene id: 1335757:SPICUR_RS07270
uniprot id: U5T7S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1335757:SPICUR RS04615
gene id: 1335757:SPICUR_RS04615
uniprot id: U5T6R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1335757:SPICUR RS06095
gene id: 1335757:SPICUR_RS06095
uniprot id: U5T4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1335757:SPICUR RS03975
gene id: 1335757:SPICUR_RS03975
uniprot id: U5T3E6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1335757:SPICUR RS03245
gene id: 1335757:SPICUR_RS03245
uniprot id: U5T2B4
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS06175
gene id: 1335757:SPICUR_RS06175
uniprot id: U5T7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS09380
gene id: 1335757:SPICUR_RS09380
uniprot id: U5T5K6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS00480
gene id: 1335757:SPICUR_RS00480
uniprot id: U5T1L5
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1335757:SPICUR RS02930
gene id: 1335757:SPICUR_RS02930
uniprot id: U5T2X6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1335757:SPICUR RS01965
gene id: 1335757:SPICUR_RS01965
uniprot id: U5T502
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS03820
gene id: 1335757:SPICUR_RS03820
uniprot id: U5T2V3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1335757:SPICUR RS01135
gene id: 1335757:SPICUR_RS01135
uniprot id: U5T4K4
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

1335757:SPICUR RS08610
gene id: 1335757:SPICUR_RS08610
uniprot id: U5T8S7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS01970
gene id: 1335757:SPICUR_RS01970
uniprot id: U5T1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS03110
gene id: 1335757:SPICUR_RS03110
uniprot id: U5T651
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS00095
gene id: 1335757:SPICUR_RS00095
uniprot id: U5T3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

1335757:SPICUR RS02505
gene id: 1335757:SPICUR_RS02505
uniprot id: U5T5Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

1335757:SPICUR RS05025
gene id: 1335757:SPICUR_RS05025
uniprot id: U5T3X0
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

1335757:SPICUR RS01810
gene id: 1335757:SPICUR_RS01810
uniprot id: U5T288
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

1335757:SPICUR RS06980
gene id: 1335757:SPICUR_RS06980
uniprot id: U5T4J2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

1335757:SPICUR RS07865
gene id: 1335757:SPICUR_RS07865
uniprot id: U5T8F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

1335757:SPICUR RS08010
gene id: 1335757:SPICUR_RS08010
uniprot id: U5T535
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

1335757:SPICUR RS04760
gene id: 1335757:SPICUR_RS04760
uniprot id: U5T319
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1335757:SPICUR RS06875
gene id: 1335757:SPICUR_RS06875
uniprot id: U5T4H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

1335757:SPICUR RS07480
gene id: 1335757:SPICUR_RS07480
uniprot id: U5T7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS03475
gene id: 1335757:SPICUR_RS03475
uniprot id: U5T5V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS02745
gene id: 1335757:SPICUR_RS02745
uniprot id: U5T5V3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS07235
gene id: 1335757:SPICUR_RS07235
uniprot id: U5T549
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS05035
gene id: 1335757:SPICUR_RS05035
uniprot id: U5T6L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1335757:SPICUR RS05340
gene id: 1335757:SPICUR_RS05340
uniprot id: U5T3D3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1335757:SPICUR RS03200
gene id: 1335757:SPICUR_RS03200
uniprot id: U5T2L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS02300
gene id: 1335757:SPICUR_RS02300
uniprot id: U5T563
names: Similarity
messages: Belongs to the leucine-binding protein family.

1335757:SPICUR RS01830
gene id: 1335757:SPICUR_RS01830
uniprot id: U5T1U0
names: Similarity
messages: Belongs to the TrpC family.

1335757:SPICUR RS00790
gene id: 1335757:SPICUR_RS00790
uniprot id: U5T101
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS09430
gene id: 1335757:SPICUR_RS09430
uniprot id: U5T5L2
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS03275
gene id: 1335757:SPICUR_RS03275
uniprot id: U5T2B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1335757:SPICUR RS05455
gene id: 1335757:SPICUR_RS05455
uniprot id: U5T6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS06415
gene id: 1335757:SPICUR_RS06415
uniprot id: U5T7R3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1335757:SPICUR RS07580
gene id: 1335757:SPICUR_RS07580
uniprot id: U5T7X6
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

1335757:SPICUR RS04565
gene id: 1335757:SPICUR_RS04565
uniprot id: U5T6Q9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1335757:SPICUR RS08770
gene id: 1335757:SPICUR_RS08770
uniprot id: U5T8V4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1335757:SPICUR RS03615
gene id: 1335757:SPICUR_RS03615
uniprot id: U5T2H1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

1335757:SPICUR RS04030
gene id: 1335757:SPICUR_RS04030
uniprot id: U5T3F3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1335757:SPICUR RS06805
gene id: 1335757:SPICUR_RS06805
uniprot id: U5T4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

1335757:SPICUR RS03320
gene id: 1335757:SPICUR_RS03320
uniprot id: U5T683
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1335757:SPICUR RS00980
gene id: 1335757:SPICUR_RS00980
uniprot id: U5T130
names: Similarity
messages: Belongs to the proline racemase family.

1335757:SPICUR RS07300
gene id: 1335757:SPICUR_RS07300
uniprot id: U5T4H0
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

1335757:SPICUR RS08825
gene id: 1335757:SPICUR_RS08825
uniprot id: U5T8G7
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

1335757:SPICUR RS02750
gene id: 1335757:SPICUR_RS02750
uniprot id: U5T5F3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS03790
gene id: 1335757:SPICUR_RS03790
uniprot id: U5T3B4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1335757:SPICUR RS07930
gene id: 1335757:SPICUR_RS07930
uniprot id: U5T4U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1335757:SPICUR RS01425
gene id: 1335757:SPICUR_RS01425
uniprot id: U5T4Q4
names: Similarity
messages: Belongs to the glutamate synthase family.

1335757:SPICUR RS06610
gene id: 1335757:SPICUR_RS06610
uniprot id: U5T7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS03385
gene id: 1335757:SPICUR_RS03385
uniprot id: U5T2P1
names: Similarity
messages: Belongs to the YciI family.

1335757:SPICUR RS09190
gene id: 1335757:SPICUR_RS09190
uniprot id: U5T8M5
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

1335757:SPICUR RS00310
gene id: 1335757:SPICUR_RS00310
uniprot id: U5T467
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1335757:SPICUR RS07325
gene id: 1335757:SPICUR_RS07325
uniprot id: U5T4H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS09280
gene id: 1335757:SPICUR_RS09280
uniprot id: U5T5J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

1335757:SPICUR RS07925
gene id: 1335757:SPICUR_RS07925
uniprot id: U5T831
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

1335757:SPICUR RS04140
gene id: 1335757:SPICUR_RS04140
uniprot id: U5T3G8
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

1335757:SPICUR RS01295
gene id: 1335757:SPICUR_RS01295
uniprot id: U5T4M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS01280
gene id: 1335757:SPICUR_RS01280
uniprot id: U5T1J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS07710
gene id: 1335757:SPICUR_RS07710
uniprot id: U5T4P7
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

1335757:SPICUR RS00930
gene id: 1335757:SPICUR_RS00930
uniprot id: U5T123
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

1335757:SPICUR RS07040
gene id: 1335757:SPICUR_RS07040
uniprot id: U5T815
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

1335757:SPICUR RS06740
gene id: 1335757:SPICUR_RS06740
uniprot id: U5T7W6
names: Similarity
messages: Belongs to the creatininase superfamily.

1335757:SPICUR RS09225
gene id: 1335757:SPICUR_RS09225
uniprot id: U5T5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

1335757:SPICUR RS07160
gene id: 1335757:SPICUR_RS07160
uniprot id: U5T537
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02470
gene id: 1335757:SPICUR_RS02470
uniprot id: U5T257
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1335757:SPICUR RS09240
gene id: 1335757:SPICUR_RS09240
uniprot id: U5T940
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06285
gene id: 1335757:SPICUR_RS06285
uniprot id: U5T3Y8
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

1335757:SPICUR RS08650
gene id: 1335757:SPICUR_RS08650
uniprot id: U5T583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1335757:SPICUR RS04635
gene id: 1335757:SPICUR_RS04635
uniprot id: U5T394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1335757:SPICUR RS04840
gene id: 1335757:SPICUR_RS04840
uniprot id: U5T3D4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1335757:SPICUR RS08085
gene id: 1335757:SPICUR_RS08085
uniprot id: U5T146
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1335757:SPICUR RS02415
gene id: 1335757:SPICUR_RS02415
uniprot id: U5T1S1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1335757:SPICUR RS05660
gene id: 1335757:SPICUR_RS05660
uniprot id: U5T7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1335757:SPICUR RS08055
gene id: 1335757:SPICUR_RS08055
uniprot id: U5T8L6
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02565
gene id: 1335757:SPICUR_RS02565
uniprot id: U5T1V4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS03690
gene id: 1335757:SPICUR_RS03690
uniprot id: U5T2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS02270
gene id: 1335757:SPICUR_RS02270
uniprot id: U5T5L7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1335757:SPICUR RS08545
gene id: 1335757:SPICUR_RS08545
uniprot id: U5T569
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS09235
gene id: 1335757:SPICUR_RS09235
uniprot id: U5T658
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

1335757:SPICUR RS03620
gene id: 1335757:SPICUR_RS03620
uniprot id: U5T2S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell inner membrane

1335757:SPICUR RS05825
gene id: 1335757:SPICUR_RS05825
uniprot id: U5T4F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

1335757:SPICUR RS01530
gene id: 1335757:SPICUR_RS01530
uniprot id: U5T1B8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

1335757:SPICUR RS01475
gene id: 1335757:SPICUR_RS01475
uniprot id: U5T4R3
names: Similarity
messages: Belongs to the citrate synthase family.

1335757:SPICUR RS09210
gene id: 1335757:SPICUR_RS09210
uniprot id: U5T935
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

1335757:SPICUR RS06660
gene id: 1335757:SPICUR_RS06660
uniprot id: U5T4U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1335757:SPICUR RS03035
gene id: 1335757:SPICUR_RS03035
uniprot id: U5T637
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

1335757:SPICUR RS07210
gene id: 1335757:SPICUR_RS07210
uniprot id: U5T547
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

1335757:SPICUR RS08660
gene id: 1335757:SPICUR_RS08660
uniprot id: U5T5X0
names: Similarity
messages: Belongs to the CFA/CMAS family.

1335757:SPICUR RS04675
gene id: 1335757:SPICUR_RS04675
uniprot id: U5T6G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1335757:SPICUR RS08590
gene id: 1335757:SPICUR_RS08590
uniprot id: U5T8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

1335757:SPICUR RS09260
gene id: 1335757:SPICUR_RS09260
uniprot id: U5T662
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01665
gene id: 1335757:SPICUR_RS01665
uniprot id: U5T5B0
names: Similarity
messages: Belongs to the YggT family.

1335757:SPICUR RS08210
gene id: 1335757:SPICUR_RS08210
uniprot id: U5T878
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1335757:SPICUR RS03125
gene id: 1335757:SPICUR_RS03125
uniprot id: U5T2K5
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1335757:SPICUR RS02765
gene id: 1335757:SPICUR_RS02765
uniprot id: U5T2B6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1335757:SPICUR RS07450
gene id: 1335757:SPICUR_RS07450
uniprot id: U5T7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS00945
gene id: 1335757:SPICUR_RS00945
uniprot id: U5T4Z2
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

1335757:SPICUR RS01010
gene id: 1335757:SPICUR_RS01010
uniprot id: U5T1E7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS00365
gene id: 1335757:SPICUR_RS00365
uniprot id: U5T0T5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

1335757:SPICUR RS02230
gene id: 1335757:SPICUR_RS02230
uniprot id: U5T1N7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

1335757:SPICUR RS02180
gene id: 1335757:SPICUR_RS02180
uniprot id: U5T1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1335757:SPICUR RS00875
gene id: 1335757:SPICUR_RS00875
uniprot id: U5T4Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

1335757:SPICUR RS01505
gene id: 1335757:SPICUR_RS01505
uniprot id: U5T1B1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

1335757:SPICUR RS02835
gene id: 1335757:SPICUR_RS02835
uniprot id: U5T5H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1335757:SPICUR RS02355
gene id: 1335757:SPICUR_RS02355
uniprot id: U5T1R1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1335757:SPICUR RS06990
gene id: 1335757:SPICUR_RS06990
uniprot id: U5T807
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

1335757:SPICUR RS07330
gene id: 1335757:SPICUR_RS07330
uniprot id: U5T4Q5
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04580
gene id: 1335757:SPICUR_RS04580
uniprot id: U5T383
names: Similarity
messages: Belongs to the peptidase S49 family.

1335757:SPICUR RS02480
gene id: 1335757:SPICUR_RS02480
uniprot id: U5T5Q2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1335757:SPICUR RS05125
gene id: 1335757:SPICUR_RS05125
uniprot id: U5T3Y9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS04745
gene id: 1335757:SPICUR_RS04745
uniprot id: U5T6U1
names: Similarity
messages: Belongs to the YkuD family.

1335757:SPICUR RS03665
gene id: 1335757:SPICUR_RS03665
uniprot id: U5T2I0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1335757:SPICUR RS06485
gene id: 1335757:SPICUR_RS06485
uniprot id: U5T4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

1335757:SPICUR RS00015
gene id: 1335757:SPICUR_RS00015
uniprot id: U5T4D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

1335757:SPICUR RS08250
gene id: 1335757:SPICUR_RS08250
uniprot id: U5T0G2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1335757:SPICUR RS07655
gene id: 1335757:SPICUR_RS07655
uniprot id: U5T7Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

1335757:SPICUR RS07075
gene id: 1335757:SPICUR_RS07075
uniprot id: U5T4C3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS00325
gene id: 1335757:SPICUR_RS00325
uniprot id: U5T1I5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS03015
gene id: 1335757:SPICUR_RS03015
uniprot id: U5T5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS08750
gene id: 1335757:SPICUR_RS08750
uniprot id: U5T8F3
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

1335757:SPICUR RS02500
gene id: 1335757:SPICUR_RS02500
uniprot id: U5T2K4
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04160
gene id: 1335757:SPICUR_RS04160
uniprot id: U5T309
names: Similarity
messages: Belongs to the peptidase M42 family.

1335757:SPICUR RS09055
gene id: 1335757:SPICUR_RS09055
uniprot id: U5T627
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1335757:SPICUR RS00320
gene id: 1335757:SPICUR_RS00320
uniprot id: U5T135
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1335757:SPICUR RS08880
gene id: 1335757:SPICUR_RS08880
uniprot id: U5T5C1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1335757:SPICUR RS06240
gene id: 1335757:SPICUR_RS06240
uniprot id: U5T464
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS02250
gene id: 1335757:SPICUR_RS02250
uniprot id: U5T555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1335757:SPICUR RS00575
gene id: 1335757:SPICUR_RS00575
uniprot id: U5T3Q1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

1335757:SPICUR RS09030
gene id: 1335757:SPICUR_RS09030
uniprot id: U5T5M0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1335757:SPICUR RS00675
gene id: 1335757:SPICUR_RS00675
uniprot id: U5T4V1
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS08890
gene id: 1335757:SPICUR_RS08890
uniprot id: U5T603
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06235
gene id: 1335757:SPICUR_RS06235
uniprot id: U5T3X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1335757:SPICUR RS07295
gene id: 1335757:SPICUR_RS07295
uniprot id: U5T7S5
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

1335757:SPICUR RS02495
gene id: 1335757:SPICUR_RS02495
uniprot id: U5T262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

1335757:SPICUR RS02590
gene id: 1335757:SPICUR_RS02590
uniprot id: U5T478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1335757:SPICUR RS08180
gene id: 1335757:SPICUR_RS08180
uniprot id: U5T874
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1335757:SPICUR RS01195
gene id: 1335757:SPICUR_RS01195
uniprot id: U5T158
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1335757:SPICUR RS06560
gene id: 1335757:SPICUR_RS06560
uniprot id: U5T7T7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS06375
gene id: 1335757:SPICUR_RS06375
uniprot id: U5T402
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS06470
gene id: 1335757:SPICUR_RS06470
uniprot id: U5T7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

1335757:SPICUR RS00735
gene id: 1335757:SPICUR_RS00735
uniprot id: U5T0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell membrane
messages: Forms a complex with DabA.
messages: Membrane
messages: Part of an energy-coupled inorganic carbon pump.

1335757:SPICUR RS03180
gene id: 1335757:SPICUR_RS03180
uniprot id: U5T664
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1335757:SPICUR RS00725
gene id: 1335757:SPICUR_RS00725
uniprot id: U5T4W0
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

1335757:SPICUR RS02325
gene id: 1335757:SPICUR_RS02325
uniprot id: U5T568
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1335757:SPICUR RS03150
gene id: 1335757:SPICUR_RS03150
uniprot id: U5T2K8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1335757:SPICUR RS05770
gene id: 1335757:SPICUR_RS05770
uniprot id: U5T3Z9
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

1335757:SPICUR RS09475
gene id: 1335757:SPICUR_RS09475
uniprot id: U5T8S5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1335757:SPICUR RS06085
gene id: 1335757:SPICUR_RS06085
uniprot id: U5T3V4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

1335757:SPICUR RS06520
gene id: 1335757:SPICUR_RS06520
uniprot id: U5T7D0
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

1335757:SPICUR RS07525
gene id: 1335757:SPICUR_RS07525
uniprot id: U5T886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

1335757:SPICUR RS09155
gene id: 1335757:SPICUR_RS09155
uniprot id: U5T645
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01690
gene id: 1335757:SPICUR_RS01690
uniprot id: U5T5B5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

1335757:SPICUR RS00835
gene id: 1335757:SPICUR_RS00835
uniprot id: U5T4F7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS05050
gene id: 1335757:SPICUR_RS05050
uniprot id: U5T3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1335757:SPICUR RS07505
gene id: 1335757:SPICUR_RS07505
uniprot id: U5T7W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

1335757:SPICUR RS04965
gene id: 1335757:SPICUR_RS04965
uniprot id: U5T356
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1335757:SPICUR RS01220
gene id: 1335757:SPICUR_RS01220
uniprot id: U5T162
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1335757:SPICUR RS01550
gene id: 1335757:SPICUR_RS01550
uniprot id: U5T4S8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

1335757:SPICUR RS02700
gene id: 1335757:SPICUR_RS02700
uniprot id: U5T1Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1335757:SPICUR RS09410
gene id: 1335757:SPICUR_RS09410
uniprot id: U5T5S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1335757:SPICUR RS03095
gene id: 1335757:SPICUR_RS03095
uniprot id: U5T290
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1335757:SPICUR RS05935
gene id: 1335757:SPICUR_RS05935
uniprot id: U5T7J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

1335757:SPICUR RS03440
gene id: 1335757:SPICUR_RS03440
uniprot id: U5T357
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

1335757:SPICUR RS09315
gene id: 1335757:SPICUR_RS09315
uniprot id: U5T670
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS06405
gene id: 1335757:SPICUR_RS06405
uniprot id: U5T486
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1335757:SPICUR RS03380
gene id: 1335757:SPICUR_RS03380
uniprot id: U5T2D7
names: Similarity
messages: Belongs to the BolA/IbaG family.

1335757:SPICUR RS06820
gene id: 1335757:SPICUR_RS06820
uniprot id: U5T7I4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS07215
gene id: 1335757:SPICUR_RS07215
uniprot id: U5T838
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1335757:SPICUR RS04025
gene id: 1335757:SPICUR_RS04025
uniprot id: U5T2Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1335757:SPICUR RS05840
gene id: 1335757:SPICUR_RS05840
uniprot id: U5T3S1
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS03370
gene id: 1335757:SPICUR_RS03370
uniprot id: U5T690
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07980
gene id: 1335757:SPICUR_RS07980
uniprot id: U5T4V2
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

1335757:SPICUR RS08105
gene id: 1335757:SPICUR_RS08105
uniprot id: U5T0E7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1335757:SPICUR RS08585
gene id: 1335757:SPICUR_RS08585
uniprot id: U5T8S4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS06325
gene id: 1335757:SPICUR_RS06325
uniprot id: U5T475
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS06565
gene id: 1335757:SPICUR_RS06565
uniprot id: U5T7D8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

1335757:SPICUR RS03120
gene id: 1335757:SPICUR_RS03120
uniprot id: U5T295
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

1335757:SPICUR RS08510
gene id: 1335757:SPICUR_RS08510
uniprot id: U5T8R5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS03195
gene id: 1335757:SPICUR_RS03195
uniprot id: U5T2A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS00235
gene id: 1335757:SPICUR_RS00235
uniprot id: U5T417
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1335757:SPICUR RS07600
gene id: 1335757:SPICUR_RS07600
uniprot id: U5T899
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

1335757:SPICUR RS00935
gene id: 1335757:SPICUR_RS00935
uniprot id: U5T1D6
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

1335757:SPICUR RS08560
gene id: 1335757:SPICUR_RS08560
uniprot id: U5T8R9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

1335757:SPICUR RS01160
gene id: 1335757:SPICUR_RS01160
uniprot id: U5T524
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

1335757:SPICUR RS00090
gene id: 1335757:SPICUR_RS00090
uniprot id: U5T4E6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS09495
gene id: 1335757:SPICUR_RS09495
uniprot id: U5T2B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS06255
gene id: 1335757:SPICUR_RS06255
uniprot id: U5T790
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01150
gene id: 1335757:SPICUR_RS01150
uniprot id: U5T1G8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07845
gene id: 1335757:SPICUR_RS07845
uniprot id: U5T820
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1335757:SPICUR RS07390
gene id: 1335757:SPICUR_RS07390
uniprot id: U5T865
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

1335757:SPICUR RS01750
gene id: 1335757:SPICUR_RS01750
uniprot id: U5T1F4
names: Similarity
messages: Belongs to the pyruvate kinase family.

1335757:SPICUR RS02540
gene id: 1335757:SPICUR_RS02540
uniprot id: U5T1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS00110
gene id: 1335757:SPICUR_RS00110
uniprot id: U5T191
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

1335757:SPICUR RS06155
gene id: 1335757:SPICUR_RS06155
uniprot id: U5T775
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

1335757:SPICUR RS02000
gene id: 1335757:SPICUR_RS02000
uniprot id: U5T1J4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02680
gene id: 1335757:SPICUR_RS02680
uniprot id: U5T298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1335757:SPICUR RS09700
gene id: 1335757:SPICUR_RS09700
uniprot id: U5T2I4
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

1335757:SPICUR RS06770
gene id: 1335757:SPICUR_RS06770
uniprot id: U5T7H5
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00670
gene id: 1335757:SPICUR_RS00670
uniprot id: U5T1P1
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1335757:SPICUR RS05620
gene id: 1335757:SPICUR_RS05620
uniprot id: U5T3N5
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

1335757:SPICUR RS00740
gene id: 1335757:SPICUR_RS00740
uniprot id: U5T1A5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS05890
gene id: 1335757:SPICUR_RS05890
uniprot id: U5T3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS07100
gene id: 1335757:SPICUR_RS07100
uniprot id: U5T4C9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1335757:SPICUR RS08070
gene id: 1335757:SPICUR_RS08070
uniprot id: U5T573
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1335757:SPICUR RS06430
gene id: 1335757:SPICUR_RS06430
uniprot id: U5T490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS09420
gene id: 1335757:SPICUR_RS09420
uniprot id: U5T971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

1335757:SPICUR RS02550
gene id: 1335757:SPICUR_RS02550
uniprot id: U5T2L4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1335757:SPICUR RS00220
gene id: 1335757:SPICUR_RS00220
uniprot id: U5T0Y2
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

1335757:SPICUR RS02830
gene id: 1335757:SPICUR_RS02830
uniprot id: U5T5W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

1335757:SPICUR RS01730
gene id: 1335757:SPICUR_RS01730
uniprot id: U5T1R9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS03960
gene id: 1335757:SPICUR_RS03960
uniprot id: U5T629
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS02510
gene id: 1335757:SPICUR_RS02510
uniprot id: U5T5A1
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

1335757:SPICUR RS02740
gene id: 1335757:SPICUR_RS02740
uniprot id: U5T2P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1335757:SPICUR RS01480
gene id: 1335757:SPICUR_RS01480
uniprot id: U5T1A6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1335757:SPICUR RS06280
gene id: 1335757:SPICUR_RS06280
uniprot id: U5T793
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

1335757:SPICUR RS03145
gene id: 1335757:SPICUR_RS03145
uniprot id: U5T299
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS09300
gene id: 1335757:SPICUR_RS09300
uniprot id: U5T8P2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1335757:SPICUR RS08635
gene id: 1335757:SPICUR_RS08635
uniprot id: U5T5W6
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

1335757:SPICUR RS03480
gene id: 1335757:SPICUR_RS03480
uniprot id: U5T2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

1335757:SPICUR RS07495
gene id: 1335757:SPICUR_RS07495
uniprot id: U5T593
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1335757:SPICUR RS07900
gene id: 1335757:SPICUR_RS07900
uniprot id: U5T828
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

1335757:SPICUR RS07985
gene id: 1335757:SPICUR_RS07985
uniprot id: U5T532
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

1335757:SPICUR RS06685
gene id: 1335757:SPICUR_RS06685
uniprot id: U5T4V5
names: Similarity
messages: Belongs to the phosphoribulokinase family.

1335757:SPICUR RS03460
gene id: 1335757:SPICUR_RS03460
uniprot id: U5T2Q1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1335757:SPICUR RS06350
gene id: 1335757:SPICUR_RS06350
uniprot id: U5T3Z7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

1335757:SPICUR RS02855
gene id: 1335757:SPICUR_RS02855
uniprot id: U5T2S0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

1335757:SPICUR RS01935
gene id: 1335757:SPICUR_RS01935
uniprot id: U5T4Z9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

1335757:SPICUR RS01130
gene id: 1335757:SPICUR_RS01130
uniprot id: U5T519
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1335757:SPICUR RS03910
gene id: 1335757:SPICUR_RS03910
uniprot id: U5T6G6
names: Similarity
messages: Belongs to the GSP E family.

1335757:SPICUR RS05685
gene id: 1335757:SPICUR_RS05685
uniprot id: U5T7F0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS00680
gene id: 1335757:SPICUR_RS00680
uniprot id: U5T4D0
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00180
gene id: 1335757:SPICUR_RS00180
uniprot id: U5T1A9
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1335757:SPICUR RS00805
gene id: 1335757:SPICUR_RS00805
uniprot id: U5T4X1
names: Similarity
messages: Belongs to the UPF0178 family.

1335757:SPICUR RS06500
gene id: 1335757:SPICUR_RS06500
uniprot id: U5T424
names: Similarity
messages: Belongs to the ClpA/ClpB family.

1335757:SPICUR RS07440
gene id: 1335757:SPICUR_RS07440
uniprot id: U5T585
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

1335757:SPICUR RS04950
gene id: 1335757:SPICUR_RS04950
uniprot id: U5T6X3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06830
gene id: 1335757:SPICUR_RS06830
uniprot id: U5T4G4
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS02430
gene id: 1335757:SPICUR_RS02430
uniprot id: U5T5P2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

1335757:SPICUR RS02205
gene id: 1335757:SPICUR_RS02205
uniprot id: U5T1N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

1335757:SPICUR RS06065
gene id: 1335757:SPICUR_RS06065
uniprot id: U5T442
names: Similarity
messages: Belongs to the proline racemase family.

1335757:SPICUR RS00845
gene id: 1335757:SPICUR_RS00845
uniprot id: U5T1B9
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

1335757:SPICUR RS03270
gene id: 1335757:SPICUR_RS03270
uniprot id: U5T5S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

1335757:SPICUR RS08060
gene id: 1335757:SPICUR_RS08060
uniprot id: U5T868
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01590
gene id: 1335757:SPICUR_RS01590
uniprot id: U5T596
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04665
gene id: 1335757:SPICUR_RS04665
uniprot id: U5T3R0
names: Similarity
messages: Belongs to the YkuD family.

1335757:SPICUR RS08690
gene id: 1335757:SPICUR_RS08690
uniprot id: U5T5X3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS01745
gene id: 1335757:SPICUR_RS01745
uniprot id: U5T4W8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS03415
gene id: 1335757:SPICUR_RS03415
uniprot id: U5T353
names: Similarity
messages: Belongs to the Nth/MutY family.

1335757:SPICUR RS05030
gene id: 1335757:SPICUR_RS05030
uniprot id: U5T6Y8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS02735
gene id: 1335757:SPICUR_RS02735
uniprot id: U5T2A9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

1335757:SPICUR RS01710
gene id: 1335757:SPICUR_RS01710
uniprot id: U5T269
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

1335757:SPICUR RS02920
gene id: 1335757:SPICUR_RS02920
uniprot id: U5T254
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

1335757:SPICUR RS03445
gene id: 1335757:SPICUR_RS03445
uniprot id: U5T6A3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

1335757:SPICUR RS00010
gene id: 1335757:SPICUR_RS00010
uniprot id: U5T169
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

1335757:SPICUR RS09010
gene id: 1335757:SPICUR_RS09010
uniprot id: U5T621
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

1335757:SPICUR RS01155
gene id: 1335757:SPICUR_RS01155
uniprot id: U5T1X5
names: Similarity
messages: Belongs to the UPF0758 family.

1335757:SPICUR RS09065
gene id: 1335757:SPICUR_RS09065
uniprot id: U5T8K7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

1335757:SPICUR RS05600
gene id: 1335757:SPICUR_RS05600
uniprot id: U5T3W3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1335757:SPICUR RS07565
gene id: 1335757:SPICUR_RS07565
uniprot id: U5T4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS02940
gene id: 1335757:SPICUR_RS02940
uniprot id: U5T0P1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1335757:SPICUR RS07305
gene id: 1335757:SPICUR_RS07305
uniprot id: U5T4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS06135
gene id: 1335757:SPICUR_RS06135
uniprot id: U5T3W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1335757:SPICUR RS02585
gene id: 1335757:SPICUR_RS02585
uniprot id: U5T5S0
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

1335757:SPICUR RS05920
gene id: 1335757:SPICUR_RS05920
uniprot id: U5T3T1
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

1335757:SPICUR RS03155
gene id: 1335757:SPICUR_RS03155
uniprot id: U5T660
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1335757:SPICUR RS02410
gene id: 1335757:SPICUR_RS02410
uniprot id: U5T0N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07540
gene id: 1335757:SPICUR_RS07540
uniprot id: U5T4V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

1335757:SPICUR RS02725
gene id: 1335757:SPICUR_RS02725
uniprot id: U5T5E8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

1335757:SPICUR RS07935
gene id: 1335757:SPICUR_RS07935
uniprot id: U5T522
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

1335757:SPICUR RS07855
gene id: 1335757:SPICUR_RS07855
uniprot id: U5T507
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

1335757:SPICUR RS07805
gene id: 1335757:SPICUR_RS07805
uniprot id: U5T4Z8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

1335757:SPICUR RS03215
gene id: 1335757:SPICUR_RS03215
uniprot id: U5T5R8
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

1335757:SPICUR RS02165
gene id: 1335757:SPICUR_RS02165
uniprot id: U5T2E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1335757:SPICUR RS01145
gene id: 1335757:SPICUR_RS01145
uniprot id: U5T0N1
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1335757:SPICUR RS09385
gene id: 1335757:SPICUR_RS09385
uniprot id: U5T5S4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS01070
gene id: 1335757:SPICUR_RS01070
uniprot id: U5T1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

1335757:SPICUR RS07650
gene id: 1335757:SPICUR_RS07650
uniprot id: U5T8A9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1335757:SPICUR RS01430
gene id: 1335757:SPICUR_RS01430
uniprot id: U5T196
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

1335757:SPICUR RS01845
gene id: 1335757:SPICUR_RS01845
uniprot id: U5T474
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1335757:SPICUR RS02875
gene id: 1335757:SPICUR_RS02875
uniprot id: U5T239
names: Similarity
messages: Belongs to the DEAD box helicase family.

1335757:SPICUR RS00485
gene id: 1335757:SPICUR_RS00485
uniprot id: U5T4S2
names: Subcellular Location Annotation
messages: Mitochondrion

1335757:SPICUR RS07800
gene id: 1335757:SPICUR_RS07800
uniprot id: U5T4R4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1335757:SPICUR RS07465
gene id: 1335757:SPICUR_RS07465
uniprot id: U5T589
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1335757:SPICUR RS07445
gene id: 1335757:SPICUR_RS07445
uniprot id: U5T872
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

1335757:SPICUR RS06910
gene id: 1335757:SPICUR_RS06910
uniprot id: U5T141
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1335757:SPICUR RS01230
gene id: 1335757:SPICUR_RS01230
uniprot id: U5T1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

1335757:SPICUR RS08775
gene id: 1335757:SPICUR_RS08775
uniprot id: U5T8F8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1335757:SPICUR RS04040
gene id: 1335757:SPICUR_RS04040
uniprot id: U5T642
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

1335757:SPICUR RS01615
gene id: 1335757:SPICUR_RS01615
uniprot id: U5T5A0
names: Similarity
messages: Belongs to the peptidase S49 family.

1335757:SPICUR RS04585
gene id: 1335757:SPICUR_RS04585
uniprot id: U5T3P6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

1335757:SPICUR RS04375
gene id: 1335757:SPICUR_RS04375
uniprot id: U5T3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1335757:SPICUR RS07785
gene id: 1335757:SPICUR_RS07785
uniprot id: U5T5E9
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

1335757:SPICUR RS00005
gene id: 1335757:SPICUR_RS00005
uniprot id: U5T0T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1335757:SPICUR RS00065
gene id: 1335757:SPICUR_RS00065
uniprot id: U5T4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

1335757:SPICUR RS07030
gene id: 1335757:SPICUR_RS07030
uniprot id: U5T4K0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1335757:SPICUR RS06465
gene id: 1335757:SPICUR_RS06465
uniprot id: U5T7S1
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

1335757:SPICUR RS03890
gene id: 1335757:SPICUR_RS03890
uniprot id: U5T617
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1335757:SPICUR RS05020
gene id: 1335757:SPICUR_RS05020
uniprot id: U5T3G9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02005
gene id: 1335757:SPICUR_RS02005
uniprot id: U5T1X0
names: Similarity
messages: Belongs to the P(II) protein family.

1335757:SPICUR RS05650
gene id: 1335757:SPICUR_RS05650
uniprot id: U5T3X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

1335757:SPICUR RS04735
gene id: 1335757:SPICUR_RS04735
uniprot id: U5T3B6
names: Similarity
messages: Belongs to the YkuD family.

1335757:SPICUR RS01725
gene id: 1335757:SPICUR_RS01725
uniprot id: U5T1F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1335757:SPICUR RS08255
gene id: 1335757:SPICUR_RS08255
uniprot id: U5T882
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

1335757:SPICUR RS03775
gene id: 1335757:SPICUR_RS03775
uniprot id: U5T601
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS08655
gene id: 1335757:SPICUR_RS08655
uniprot id: U5T5G9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

1335757:SPICUR RS00360
gene id: 1335757:SPICUR_RS00360
uniprot id: U5T473
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1335757:SPICUR RS07010
gene id: 1335757:SPICUR_RS07010
uniprot id: U5T509
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

1335757:SPICUR RS02710
gene id: 1335757:SPICUR_RS02710
uniprot id: U5T2P3
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS02215
gene id: 1335757:SPICUR_RS02215
uniprot id: U5T2F6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1335757:SPICUR RS01050
gene id: 1335757:SPICUR_RS01050
uniprot id: U5T1V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

1335757:SPICUR RS07240
gene id: 1335757:SPICUR_RS07240
uniprot id: U5T843
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04670
gene id: 1335757:SPICUR_RS04670
uniprot id: U5T6S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

1335757:SPICUR RS03175
gene id: 1335757:SPICUR_RS03175
uniprot id: U5T318
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1335757:SPICUR RS04890
gene id: 1335757:SPICUR_RS04890
uniprot id: U5T3E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1335757:SPICUR RS08920
gene id: 1335757:SPICUR_RS08920
uniprot id: U5T8Y2
names: Similarity
messages: Belongs to the universal stress protein A family.

1335757:SPICUR RS08305
gene id: 1335757:SPICUR_RS08305
uniprot id: U5T885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1335757:SPICUR RS07570
gene id: 1335757:SPICUR_RS07570
uniprot id: U5T5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

1335757:SPICUR RS04880
gene id: 1335757:SPICUR_RS04880
uniprot id: U5T6J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1335757:SPICUR RS00040
gene id: 1335757:SPICUR_RS00040
uniprot id: U5T4D5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1335757:SPICUR RS05285
gene id: 1335757:SPICUR_RS05285
uniprot id: U5T6Q7
names: Similarity
messages: Belongs to the SufE family.

1335757:SPICUR RS07535
gene id: 1335757:SPICUR_RS07535
uniprot id: U5T4L5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

1335757:SPICUR RS06570
gene id: 1335757:SPICUR_RS06570
uniprot id: U5T436
names: Similarity
messages: Belongs to the GppA/Ppx family.

1335757:SPICUR RS05015
gene id: 1335757:SPICUR_RS05015
uniprot id: U5T363
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

1335757:SPICUR RS06655
gene id: 1335757:SPICUR_RS06655
uniprot id: U5T4C8
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS08430
gene id: 1335757:SPICUR_RS08430
uniprot id: U5T8Q5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

1335757:SPICUR RS05145
gene id: 1335757:SPICUR_RS05145
uniprot id: U5T3J1
names: Similarity
messages: Belongs to the hyi family.

1335757:SPICUR RS07170
gene id: 1335757:SPICUR_RS07170
uniprot id: U5T7Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1335757:SPICUR RS09015
gene id: 1335757:SPICUR_RS09015
uniprot id: U5T8Z9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

1335757:SPICUR RS01815
gene id: 1335757:SPICUR_RS01815
uniprot id: U5T5E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1335757:SPICUR RS07150
gene id: 1335757:SPICUR_RS07150
uniprot id: U5T4D9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS04785
gene id: 1335757:SPICUR_RS04785
uniprot id: U5T324
names: Similarity
messages: Belongs to the RecJ family.

1335757:SPICUR RS08580
gene id: 1335757:SPICUR_RS08580
uniprot id: U5T5V8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1335757:SPICUR RS03065
gene id: 1335757:SPICUR_RS03065
uniprot id: U5T5P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1335757:SPICUR RS03410
gene id: 1335757:SPICUR_RS03410
uniprot id: U5T2P5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

1335757:SPICUR RS04035
gene id: 1335757:SPICUR_RS04035
uniprot id: U5T6I3
names: Similarity
messages: Belongs to the aspartokinase family.

1335757:SPICUR RS07025
gene id: 1335757:SPICUR_RS07025
uniprot id: U5T4B3
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

1335757:SPICUR RS09455
gene id: 1335757:SPICUR_RS09455
uniprot id: U5T5L5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07585
gene id: 1335757:SPICUR_RS07585
uniprot id: U5T4M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1335757:SPICUR RS09285
gene id: 1335757:SPICUR_RS09285
uniprot id: U5T5Q6
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS03465
gene id: 1335757:SPICUR_RS03465
uniprot id: U5T362
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

1335757:SPICUR RS04130
gene id: 1335757:SPICUR_RS04130
uniprot id: U5T2Q0
names: Similarity
messages: Belongs to the GSP E family.

1335757:SPICUR RS09435
gene id: 1335757:SPICUR_RS09435
uniprot id: U5T5T5
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

1335757:SPICUR RS05675
gene id: 1335757:SPICUR_RS05675
uniprot id: U5T3Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS03990
gene id: 1335757:SPICUR_RS03990
uniprot id: U5T2M7
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00030
gene id: 1335757:SPICUR_RS00030
uniprot id: U5T0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

1335757:SPICUR RS00640
gene id: 1335757:SPICUR_RS00640
uniprot id: U5T186
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

1335757:SPICUR RS09425
gene id: 1335757:SPICUR_RS09425
uniprot id: U5T8R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1335757:SPICUR RS04135
gene id: 1335757:SPICUR_RS04135
uniprot id: U5T304
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

1335757:SPICUR RS07165
gene id: 1335757:SPICUR_RS07165
uniprot id: U5T834
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS00450
gene id: 1335757:SPICUR_RS00450
uniprot id: U5T157
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1335757:SPICUR RS02820
gene id: 1335757:SPICUR_RS02820
uniprot id: U5T2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

1335757:SPICUR RS04295
gene id: 1335757:SPICUR_RS04295
uniprot id: U5T691
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1335757:SPICUR RS06345
gene id: 1335757:SPICUR_RS06345
uniprot id: U5T7A1
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

1335757:SPICUR RS03350
gene id: 1335757:SPICUR_RS03350
uniprot id: U5T5T8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1335757:SPICUR RS01525
gene id: 1335757:SPICUR_RS01525
uniprot id: U5T4S3
names: Similarity
messages: Belongs to the RutC family.

1335757:SPICUR RS01520
gene id: 1335757:SPICUR_RS01520
uniprot id: U5T584
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1335757:SPICUR RS00155
gene id: 1335757:SPICUR_RS00155
uniprot id: U5T1A4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1335757:SPICUR RS06190
gene id: 1335757:SPICUR_RS06190
uniprot id: U5T458
names: Similarity
messages: Belongs to the SDHAF4 family.

1335757:SPICUR RS01120
gene id: 1335757:SPICUR_RS01120
uniprot id: U5T1G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

1335757:SPICUR RS00215
gene id: 1335757:SPICUR_RS00215
uniprot id: U5T0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

1335757:SPICUR RS01215
gene id: 1335757:SPICUR_RS01215
uniprot id: U5T4L7
names: Subcellular Location Annotation
messages: Cytoplasm

1335757:SPICUR RS08785
gene id: 1335757:SPICUR_RS08785
uniprot id: U5T5I8
names: Similarity
messages: Belongs to the FrmR/RcnR family.

1335757:SPICUR RS08160
gene id: 1335757:SPICUR_RS08160
uniprot id: U5T8M4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1335757:SPICUR RS01805
gene id: 1335757:SPICUR_RS01805
uniprot id: U5T1T5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1335757:SPICUR RS04860
gene id: 1335757:SPICUR_RS04860
uniprot id: U5T337
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1335757:SPICUR RS09080
gene id: 1335757:SPICUR_RS09080
uniprot id: U5T632
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1335757:SPICUR RS06540
gene id: 1335757:SPICUR_RS06540
uniprot id: U5T7D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS01500
gene id: 1335757:SPICUR_RS01500
uniprot id: U5T4R9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1335757:SPICUR RS07475
gene id: 1335757:SPICUR_RS07475
uniprot id: U5T875
names: Similarity
messages: Belongs to the GSP E family.

1335757:SPICUR RS05805
gene id: 1335757:SPICUR_RS05805
uniprot id: U5T7H0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS06275
gene id: 1335757:SPICUR_RS06275
uniprot id: U5T7P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

1335757:SPICUR RS02385
gene id: 1335757:SPICUR_RS02385
uniprot id: U5T1R6
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

1335757:SPICUR RS04855
gene id: 1335757:SPICUR_RS04855
uniprot id: U5T6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

1335757:SPICUR RS00460
gene id: 1335757:SPICUR_RS00460
uniprot id: U5T4R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

1335757:SPICUR RS09295
gene id: 1335757:SPICUR_RS09295
uniprot id: U5T949
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

1335757:SPICUR RS04560
gene id: 1335757:SPICUR_RS04560
uniprot id: U5T3P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

1335757:SPICUR RS01755
gene id: 1335757:SPICUR_RS01755
uniprot id: U5T1S5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1335757:SPICUR RS05755
gene id: 1335757:SPICUR_RS05755
uniprot id: U5T4E5
names: Similarity
messages: Belongs to the asparaginase 1 family.

1335757:SPICUR RS08135
gene id: 1335757:SPICUR_RS08135
uniprot id: U5T598
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1335757:SPICUR RS07185
gene id: 1335757:SPICUR_RS07185
uniprot id: U5T542
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1335757:SPICUR RS01320
gene id: 1335757:SPICUR_RS01320
uniprot id: U5T4N3
names: Similarity
messages: Belongs to the AlaDH/PNT family.

1335757:SPICUR RS06230
gene id: 1335757:SPICUR_RS06230
uniprot id: U5T786
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

1335757:SPICUR RS02055
gene id: 1335757:SPICUR_RS02055
uniprot id: U5T1Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS04955
gene id: 1335757:SPICUR_RS04955
uniprot id: U5T6K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1335757:SPICUR RS04845
gene id: 1335757:SPICUR_RS04845
uniprot id: U5T3T9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS04010
gene id: 1335757:SPICUR_RS04010
uniprot id: U5T639
names: Similarity
messages: Belongs to the universal stress protein A family.

1335757:SPICUR RS08565
gene id: 1335757:SPICUR_RS08565
uniprot id: U5T8C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1335757:SPICUR RS05985
gene id: 1335757:SPICUR_RS05985
uniprot id: U5T4I8
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

1335757:SPICUR RS03240
gene id: 1335757:SPICUR_RS03240
uniprot id: U5T5S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS06515
gene id: 1335757:SPICUR_RS06515
uniprot id: U5T7S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

1335757:SPICUR RS02985
gene id: 1335757:SPICUR_RS02985
uniprot id: U5T270
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1335757:SPICUR RS06105
gene id: 1335757:SPICUR_RS06105
uniprot id: U5T769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1335757:SPICUR RS01265
gene id: 1335757:SPICUR_RS01265
uniprot id: U5T543
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

1335757:SPICUR RS01115
gene id: 1335757:SPICUR_RS01115
uniprot id: U5T148
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1335757:SPICUR RS08845
gene id: 1335757:SPICUR_RS08845
uniprot id: U5T8W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1335757:SPICUR RS06265
gene id: 1335757:SPICUR_RS06265
uniprot id: U5T468
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1335757:SPICUR RS04895
gene id: 1335757:SPICUR_RS04895
uniprot id: U5T3U5
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

1335757:SPICUR RS04090
gene id: 1335757:SPICUR_RS04090
uniprot id: U5T6J0
names: Similarity
messages: Belongs to the GSP E family.

1335757:SPICUR RS02080
gene id: 1335757:SPICUR_RS02080
uniprot id: U5T1Y6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1335757:SPICUR RS08100
gene id: 1335757:SPICUR_RS08100
uniprot id: U5T870
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1335757:SPICUR RS07130
gene id: 1335757:SPICUR_RS07130
uniprot id: U5T4L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

1335757:SPICUR RS04525
gene id: 1335757:SPICUR_RS04525
uniprot id: U5T2X1
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

1335757:SPICUR RS00495
gene id: 1335757:SPICUR_RS00495
uniprot id: U5T0V8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS04005
gene id: 1335757:SPICUR_RS04005
uniprot id: U5T6I0
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00345
gene id: 1335757:SPICUR_RS00345
uniprot id: U5T139
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

1335757:SPICUR RS09060
gene id: 1335757:SPICUR_RS09060
uniprot id: U5T906
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

1335757:SPICUR RS02805
gene id: 1335757:SPICUR_RS02805
uniprot id: U5T5G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1335757:SPICUR RS09305
gene id: 1335757:SPICUR_RS09305
uniprot id: U5T5J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

1335757:SPICUR RS04150
gene id: 1335757:SPICUR_RS04150
uniprot id: U5T663
names: Cofactor
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS04275
gene id: 1335757:SPICUR_RS04275
uniprot id: U5T2S8
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

1335757:SPICUR RS06130
gene id: 1335757:SPICUR_RS06130
uniprot id: U5T773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

1335757:SPICUR RS07955
gene id: 1335757:SPICUR_RS07955
uniprot id: U5T4U6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1335757:SPICUR RS07455
gene id: 1335757:SPICUR_RS07455
uniprot id: U5T4J9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

1335757:SPICUR RS01175
gene id: 1335757:SPICUR_RS01175
uniprot id: U5T1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1335757:SPICUR RS08150
gene id: 1335757:SPICUR_RS08150
uniprot id: U5T0R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1335757:SPICUR RS07595
gene id: 1335757:SPICUR_RS07595
uniprot id: U5T5B2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

1335757:SPICUR RS00840
gene id: 1335757:SPICUR_RS00840
uniprot id: U5T108
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

1335757:SPICUR RS07885
gene id: 1335757:SPICUR_RS07885
uniprot id: U5T3T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

1335757:SPICUR RS04555
gene id: 1335757:SPICUR_RS04555
uniprot id: U5T378
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

1335757:SPICUR RS08195
gene id: 1335757:SPICUR_RS08195
uniprot id: U5T5Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1335757:SPICUR RS03205
gene id: 1335757:SPICUR_RS03205
uniprot id: U5T322
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS07070
gene id: 1335757:SPICUR_RS07070
uniprot id: U5T7N4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS04475
gene id: 1335757:SPICUR_RS04475
uniprot id: U5T6C4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1335757:SPICUR RS07420
gene id: 1335757:SPICUR_RS07420
uniprot id: U5T869
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

1335757:SPICUR RS06210
gene id: 1335757:SPICUR_RS06210
uniprot id: U5T3X3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS09810
gene id: 1335757:SPICUR_RS09810
uniprot id: U5T5Y0
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

1335757:SPICUR RS01240
gene id: 1335757:SPICUR_RS01240
uniprot id: U5T4M1
names: Similarity
messages: Belongs to the histone deacetylase family.

1335757:SPICUR RS08220
gene id: 1335757:SPICUR_RS08220
uniprot id: U5T4C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1335757:SPICUR RS00035
gene id: 1335757:SPICUR_RS00035
uniprot id: U5T175
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1335757:SPICUR RS06395
gene id: 1335757:SPICUR_RS06395
uniprot id: U5T7A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1335757:SPICUR RS01310
gene id: 1335757:SPICUR_RS01310
uniprot id: U5T202
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1335757:SPICUR RS06975
gene id: 1335757:SPICUR_RS06975
uniprot id: U5T4A2
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

1335757:SPICUR RS08235
gene id: 1335757:SPICUR_RS08235
uniprot id: U5T5R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1335757:SPICUR RS07105
gene id: 1335757:SPICUR_RS07105
uniprot id: U5T4L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

1335757:SPICUR RS01600
gene id: 1335757:SPICUR_RS01600
uniprot id: U5T1D1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1335757:SPICUR RS09445
gene id: 1335757:SPICUR_RS09445
uniprot id: U5T977
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

1335757:SPICUR RS01700
gene id: 1335757:SPICUR_RS01700
uniprot id: U5T1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

1335757:SPICUR RS05445
gene id: 1335757:SPICUR_RS05445
uniprot id: U5T452
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS01670
gene id: 1335757:SPICUR_RS01670
uniprot id: U5T4V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1335757:SPICUR RS00385
gene id: 1335757:SPICUR_RS00385
uniprot id: U5T480
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS01180
gene id: 1335757:SPICUR_RS01180
uniprot id: U5T1X9
names: Similarity
messages: Belongs to the peptidase M16 family.

1335757:SPICUR RS09485
gene id: 1335757:SPICUR_RS09485
uniprot id: U5T4G3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

1335757:SPICUR RS09250
gene id: 1335757:SPICUR_RS09250
uniprot id: U5T5I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

1335757:SPICUR RS03335
gene id: 1335757:SPICUR_RS03335
uniprot id: U5T2N3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

1335757:SPICUR RS06510
gene id: 1335757:SPICUR_RS06510
uniprot id: U5T4S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS04455
gene id: 1335757:SPICUR_RS04455
uniprot id: U5T2V9
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

1335757:SPICUR RS04945
gene id: 1335757:SPICUR_RS04945
uniprot id: U5T3V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1335757:SPICUR RS02195
gene id: 1335757:SPICUR_RS02195
uniprot id: U5T5K8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

1335757:SPICUR RS02865
gene id: 1335757:SPICUR_RS02865
uniprot id: U5T5J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1335757:SPICUR RS04575
gene id: 1335757:SPICUR_RS04575
uniprot id: U5T2Y0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1335757:SPICUR RS02280
gene id: 1335757:SPICUR_RS02280
uniprot id: U5T1P6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

1335757:SPICUR RS02575
gene id: 1335757:SPICUR_RS02575
uniprot id: U5T125
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS01400
gene id: 1335757:SPICUR_RS01400
uniprot id: U5T4P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1335757:SPICUR RS02460
gene id: 1335757:SPICUR_RS02460
uniprot id: U5T592
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1335757:SPICUR RS03285
gene id: 1335757:SPICUR_RS03285
uniprot id: U5T335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

1335757:SPICUR RS07460
gene id: 1335757:SPICUR_RS07460
uniprot id: U5T4T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

1335757:SPICUR RS02185
gene id: 1335757:SPICUR_RS02185
uniprot id: U5T206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

1335757:SPICUR RS07055
gene id: 1335757:SPICUR_RS07055
uniprot id: U5T4K3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

1335757:SPICUR RS02085
gene id: 1335757:SPICUR_RS02085
uniprot id: U5T2D5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS04290
gene id: 1335757:SPICUR_RS04290
uniprot id: U5T6L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1335757:SPICUR RS07485
gene id: 1335757:SPICUR_RS07485
uniprot id: U5T4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

1335757:SPICUR RS04260
gene id: 1335757:SPICUR_RS04260
uniprot id: U5T3J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS02255
gene id: 1335757:SPICUR_RS02255
uniprot id: U5T1P2
names: Similarity
messages: Belongs to the PhoH family.

1335757:SPICUR RS03870
gene id: 1335757:SPICUR_RS03870
uniprot id: U5T2K9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

1335757:SPICUR RS07680
gene id: 1335757:SPICUR_RS07680
uniprot id: U5T7Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

1335757:SPICUR RS07615
gene id: 1335757:SPICUR_RS07615
uniprot id: U5T4W5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

1335757:SPICUR RS02265
gene id: 1335757:SPICUR_RS02265
uniprot id: U5T2G4
names: Subcellular Location Annotation
messages: Cytoplasm

1335757:SPICUR RS08155
gene id: 1335757:SPICUR_RS08155
uniprot id: U5T155
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1335757:SPICUR RS02485
gene id: 1335757:SPICUR_RS02485
uniprot id: U5T595
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

1335757:SPICUR RS08230
gene id: 1335757:SPICUR_RS08230
uniprot id: U5T5A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1335757:SPICUR RS05960
gene id: 1335757:SPICUR_RS05960
uniprot id: U5T7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS04125
gene id: 1335757:SPICUR_RS04125
uniprot id: U5T657
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS07135
gene id: 1335757:SPICUR_RS07135
uniprot id: U5T531
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1335757:SPICUR RS06020
gene id: 1335757:SPICUR_RS06020
uniprot id: U5T4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS03805
gene id: 1335757:SPICUR_RS03805
uniprot id: U5T3R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1335757:SPICUR RS04385
gene id: 1335757:SPICUR_RS04385
uniprot id: U5T2U6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS07610
gene id: 1335757:SPICUR_RS07610
uniprot id: U5T4M6
names: Similarity
messages: Belongs to the UPF0102 family.

1335757:SPICUR RS00290
gene id: 1335757:SPICUR_RS00290
uniprot id: U5T0S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

1335757:SPICUR RS05000
gene id: 1335757:SPICUR_RS05000
uniprot id: U5T3W4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1335757:SPICUR RS01170
gene id: 1335757:SPICUR_RS01170
uniprot id: U5T154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

1335757:SPICUR RS01445
gene id: 1335757:SPICUR_RS01445
uniprot id: U5T570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. PilQ subfamily.
messages: Cell outer membrane
messages: Membrane

1335757:SPICUR RS04870
gene id: 1335757:SPICUR_RS04870
uniprot id: U5T3U3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07050
gene id: 1335757:SPICUR_RS07050
uniprot id: U5T4B8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

1335757:SPICUR RS05640
gene id: 1335757:SPICUR_RS05640
uniprot id: U5T705
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

1335757:SPICUR RS00615
gene id: 1335757:SPICUR_RS00615
uniprot id: U5T181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS01635
gene id: 1335757:SPICUR_RS01635
uniprot id: U5T256
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS06680
gene id: 1335757:SPICUR_RS06680
uniprot id: U5T4D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

1335757:SPICUR RS03490
gene id: 1335757:SPICUR_RS03490
uniprot id: U5T485
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

1335757:SPICUR RS01435
gene id: 1335757:SPICUR_RS01435
uniprot id: U5T1L7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS00525
gene id: 1335757:SPICUR_RS00525
uniprot id: U5T0W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

1335757:SPICUR RS06850
gene id: 1335757:SPICUR_RS06850
uniprot id: U5T477
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

1335757:SPICUR RS01380
gene id: 1335757:SPICUR_RS01380
uniprot id: U5T187
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

1335757:SPICUR RS08090
gene id: 1335757:SPICUR_RS08090
uniprot id: U5T4A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1335757:SPICUR RS05155
gene id: 1335757:SPICUR_RS05155
uniprot id: U5T712
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

1335757:SPICUR RS03695
gene id: 1335757:SPICUR_RS03695
uniprot id: U5T2T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS08095
gene id: 1335757:SPICUR_RS08095
uniprot id: U5T3T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1335757:SPICUR RS00115
gene id: 1335757:SPICUR_RS00115
uniprot id: U5T4F1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

1335757:SPICUR RS07415
gene id: 1335757:SPICUR_RS07415
uniprot id: U5T581
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

1335757:SPICUR RS02790
gene id: 1335757:SPICUR_RS02790
uniprot id: U5T2C2
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

1335757:SPICUR RS02290
gene id: 1335757:SPICUR_RS02290
uniprot id: U5T2G9
names: Similarity
messages: Belongs to the rubredoxin family.

1335757:SPICUR RS06950
gene id: 1335757:SPICUR_RS06950
uniprot id: U5T497
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1335757:SPICUR RS09450
gene id: 1335757:SPICUR_RS09450
uniprot id: U5T8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

1335757:SPICUR RS01000
gene id: 1335757:SPICUR_RS01000
uniprot id: U5T4I5
names: Similarity
messages: Belongs to the leucine-binding protein family.

1335757:SPICUR RS06835
gene id: 1335757:SPICUR_RS06835
uniprot id: U5T4Y1
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

1335757:SPICUR RS00655
gene id: 1335757:SPICUR_RS00655
uniprot id: U5T4C4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1335757:SPICUR RS07020
gene id: 1335757:SPICUR_RS07020
uniprot id: U5T7M4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1335757:SPICUR RS07715
gene id: 1335757:SPICUR_RS07715
uniprot id: U5T4Y3
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

1335757:SPICUR RS07125
gene id: 1335757:SPICUR_RS07125
uniprot id: U5T4D4
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

1335757:SPICUR RS01515
gene id: 1335757:SPICUR_RS01515
uniprot id: U5T236
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1335757:SPICUR RS08080
gene id: 1335757:SPICUR_RS08080
uniprot id: U5T8M1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1335757:SPICUR RS01900
gene id: 1335757:SPICUR_RS01900
uniprot id: U5T2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

1335757:SPICUR RS04980
gene id: 1335757:SPICUR_RS04980
uniprot id: U5T6X8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

1335757:SPICUR RS06185
gene id: 1335757:SPICUR_RS06185
uniprot id: U5T3W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

1335757:SPICUR RS08000
gene id: 1335757:SPICUR_RS08000
uniprot id: U5T840
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1335757:SPICUR RS00305
gene id: 1335757:SPICUR_RS00305
uniprot id: U5T4N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1335757:SPICUR RS08170
gene id: 1335757:SPICUR_RS08170
uniprot id: U5T3U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1335757:SPICUR RS02815
gene id: 1335757:SPICUR_RS02815
uniprot id: U5T205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

1335757:SPICUR RS05010
gene id: 1335757:SPICUR_RS05010
uniprot id: U5T6L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1335757:SPICUR RS06870
gene id: 1335757:SPICUR_RS06870
uniprot id: U5T484
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS02850
gene id: 1335757:SPICUR_RS02850
uniprot id: U5T0C2
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

1335757:SPICUR RS08200
gene id: 1335757:SPICUR_RS08200
uniprot id: U5T0S3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1335757:SPICUR RS08790
gene id: 1335757:SPICUR_RS08790
uniprot id: U5T5Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1335757:SPICUR RS09400
gene id: 1335757:SPICUR_RS09400
uniprot id: U5T8R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1335757:SPICUR RS04460
gene id: 1335757:SPICUR_RS04460
uniprot id: U5T361
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS01495
gene id: 1335757:SPICUR_RS01495
uniprot id: U5T579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1335757:SPICUR RS03295
gene id: 1335757:SPICUR_RS03295
uniprot id: U5T128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1335757:SPICUR RS00400
gene id: 1335757:SPICUR_RS00400
uniprot id: U5T1J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1335757:SPICUR RS08020
gene id: 1335757:SPICUR_RS08020
uniprot id: U5T5J4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

1335757:SPICUR RS00135
gene id: 1335757:SPICUR_RS00135
uniprot id: U5T197
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1335757:SPICUR RS06710
gene id: 1335757:SPICUR_RS06710
uniprot id: U5T4W1
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

1335757:SPICUR RS07360
gene id: 1335757:SPICUR_RS07360
uniprot id: U5T498
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1335757:SPICUR RS03530
gene id: 1335757:SPICUR_RS03530
uniprot id: U5T5X1
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS06435
gene id: 1335757:SPICUR_RS06435
uniprot id: U5T4Q8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

1335757:SPICUR RS08410
gene id: 1335757:SPICUR_RS08410
uniprot id: U5T898
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS08380
gene id: 1335757:SPICUR_RS08380
uniprot id: U5T8P7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

1335757:SPICUR RS04170
gene id: 1335757:SPICUR_RS04170
uniprot id: U5T6J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

1335757:SPICUR RS08245
gene id: 1335757:SPICUR_RS08245
uniprot id: U5T3V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1335757:SPICUR RS02785
gene id: 1335757:SPICUR_RS02785
uniprot id: U5T200
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

1335757:SPICUR RS07920
gene id: 1335757:SPICUR_RS07920
uniprot id: U5T8G4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

1335757:SPICUR RS03550
gene id: 1335757:SPICUR_RS03550
uniprot id: U5T6B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS07575
gene id: 1335757:SPICUR_RS07575
uniprot id: U5T893
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02305
gene id: 1335757:SPICUR_RS02305
uniprot id: U5T1Q1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS02525
gene id: 1335757:SPICUR_RS02525
uniprot id: U5T2L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

1335757:SPICUR RS00690
gene id: 1335757:SPICUR_RS00690
uniprot id: U5T195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS01625
gene id: 1335757:SPICUR_RS01625
uniprot id: U5T1D5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS08065
gene id: 1335757:SPICUR_RS08065
uniprot id: U5T4Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1335757:SPICUR RS01165
gene id: 1335757:SPICUR_RS01165
uniprot id: U5T4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

1335757:SPICUR RS00545
gene id: 1335757:SPICUR_RS00545
uniprot id: U5T4A5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1335757:SPICUR RS02545
gene id: 1335757:SPICUR_RS02545
uniprot id: U5T271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS08425
gene id: 1335757:SPICUR_RS08425
uniprot id: U5T5T9
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

1335757:SPICUR RS09020
gene id: 1335757:SPICUR_RS09020
uniprot id: U5T8J9
names: Similarity
messages: Belongs to the fructosamine kinase family.

1335757:SPICUR RS00795
gene id: 1335757:SPICUR_RS00795
uniprot id: U5T1B2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

1335757:SPICUR RS03965
gene id: 1335757:SPICUR_RS03965
uniprot id: U5T2M3
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00445
gene id: 1335757:SPICUR_RS00445
uniprot id: U5T0U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1335757:SPICUR RS00520
gene id: 1335757:SPICUR_RS00520
uniprot id: U5T4A1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1335757:SPICUR RS03885
gene id: 1335757:SPICUR_RS03885
uniprot id: U5T6G3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

1335757:SPICUR RS00810
gene id: 1335757:SPICUR_RS00810
uniprot id: U5T4F3
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS06545
gene id: 1335757:SPICUR_RS06545
uniprot id: U5T432
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS01990
gene id: 1335757:SPICUR_RS01990
uniprot id: U5T5H2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1335757:SPICUR RS01705
gene id: 1335757:SPICUR_RS01705
uniprot id: U5T1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

1335757:SPICUR RS06840
gene id: 1335757:SPICUR_RS06840
uniprot id: U5T7Y5
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

1335757:SPICUR RS04430
gene id: 1335757:SPICUR_RS04430
uniprot id: U5T2V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

1335757:SPICUR RS00275
gene id: 1335757:SPICUR_RS00275
uniprot id: U5T1F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS00200
gene id: 1335757:SPICUR_RS00200
uniprot id: U5T0X7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

1335757:SPICUR RS06460
gene id: 1335757:SPICUR_RS06460
uniprot id: U5T4R2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

1335757:SPICUR RS03160
gene id: 1335757:SPICUR_RS03160
uniprot id: U5T5Q7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS04940
gene id: 1335757:SPICUR_RS04940
uniprot id: U5T3F6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

1335757:SPICUR RS06625
gene id: 1335757:SPICUR_RS06625
uniprot id: U5T0Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

1335757:SPICUR RS02025
gene id: 1335757:SPICUR_RS02025
uniprot id: U5T1K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

1335757:SPICUR RS00535
gene id: 1335757:SPICUR_RS00535
uniprot id: U5T1M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

1335757:SPICUR RS08670
gene id: 1335757:SPICUR_RS08670
uniprot id: U5T8E0
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

1335757:SPICUR RS03500
gene id: 1335757:SPICUR_RS03500
uniprot id: U5T6B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

1335757:SPICUR RS01960
gene id: 1335757:SPICUR_RS01960
uniprot id: U5T5G8
names: Similarity
messages: Belongs to the universal stress protein A family.

1335757:SPICUR RS02035
gene id: 1335757:SPICUR_RS02035
uniprot id: U5T2C6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1335757:SPICUR RS05225
gene id: 1335757:SPICUR_RS05225
uniprot id: U5T411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS02100
gene id: 1335757:SPICUR_RS02100
uniprot id: U5T1L6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS04600
gene id: 1335757:SPICUR_RS04600
uniprot id: U5T2Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

1335757:SPICUR RS07015
gene id: 1335757:SPICUR_RS07015
uniprot id: U5T811
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

1335757:SPICUR RS00765
gene id: 1335757:SPICUR_RS00765
uniprot id: U5T1A8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1335757:SPICUR RS06445
gene id: 1335757:SPICUR_RS06445
uniprot id: U5T7B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1335757:SPICUR RS08145
gene id: 1335757:SPICUR_RS08145
uniprot id: U5T5P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1335757:SPICUR RS00315
gene id: 1335757:SPICUR_RS00315
uniprot id: U5T0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1335757:SPICUR RS07230
gene id: 1335757:SPICUR_RS07230
uniprot id: U5T4N6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1335757:SPICUR RS03555
gene id: 1335757:SPICUR_RS03555
uniprot id: U5T5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

1335757:SPICUR RS07630
gene id: 1335757:SPICUR_RS07630
uniprot id: U5T7Y6
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

1335757:SPICUR RS01660
gene id: 1335757:SPICUR_RS01660
uniprot id: U5T261
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

1335757:SPICUR RS06645
gene id: 1335757:SPICUR_RS06645
uniprot id: U5T7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

1335757:SPICUR RS03290
gene id: 1335757:SPICUR_RS03290
uniprot id: U5T678
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1335757:SPICUR RS05765
gene id: 1335757:SPICUR_RS05765
uniprot id: U5T723
names: Similarity
messages: Belongs to the IMPACT family.

1335757:SPICUR RS07555
gene id: 1335757:SPICUR_RS07555
uniprot id: U5T7X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

1335757:SPICUR RS01740
gene id: 1335757:SPICUR_RS01740
uniprot id: U5T5C6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1335757:SPICUR RS08570
gene id: 1335757:SPICUR_RS08570
uniprot id: U5T574
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04885
gene id: 1335757:SPICUR_RS04885
uniprot id: U5T342
names: Subcellular Location Annotation
messages: Cytoplasm

1335757:SPICUR RS07350
gene id: 1335757:SPICUR_RS07350
uniprot id: U5T4I0
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS02160
gene id: 1335757:SPICUR_RS02160
uniprot id: U5T201
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

1335757:SPICUR RS08475
gene id: 1335757:SPICUR_RS08475
uniprot id: U5T5U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

1335757:SPICUR RS07200
gene id: 1335757:SPICUR_RS07200
uniprot id: U5T4F0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

1335757:SPICUR RS01315
gene id: 1335757:SPICUR_RS01315
uniprot id: U5T550
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

1335757:SPICUR RS02845
gene id: 1335757:SPICUR_RS02845
uniprot id: U5T2D2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

1335757:SPICUR RS04380
gene id: 1335757:SPICUR_RS04380
uniprot id: U5T6A5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

1335757:SPICUR RS02610
gene id: 1335757:SPICUR_RS02610
uniprot id: U5T2M4
names: Similarity
messages: Belongs to the WrbA family.

1335757:SPICUR RS06455
gene id: 1335757:SPICUR_RS06455
uniprot id: U5T493
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS02515
gene id: 1335757:SPICUR_RS02515
uniprot id: U5T1U4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

1335757:SPICUR RS02770
gene id: 1335757:SPICUR_RS02770
uniprot id: U5T2Q3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1335757:SPICUR RS06930
gene id: 1335757:SPICUR_RS06930
uniprot id: U5T4I3
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS08175
gene id: 1335757:SPICUR_RS08175
uniprot id: U5T0F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1335757:SPICUR RS07815
gene id: 1335757:SPICUR_RS07815
uniprot id: U5T8E3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

1335757:SPICUR RS00240
gene id: 1335757:SPICUR_RS00240
uniprot id: U5T0M3
names: Similarity
messages: Belongs to the Smg family.

1335757:SPICUR RS07515
gene id: 1335757:SPICUR_RS07515
uniprot id: U5T4U4
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

1335757:SPICUR RS02640
gene id: 1335757:SPICUR_RS02640
uniprot id: U5T5T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1335757:SPICUR RS07500
gene id: 1335757:SPICUR_RS07500
uniprot id: U5T881
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1335757:SPICUR RS01080
gene id: 1335757:SPICUR_RS01080
uniprot id: U5T510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1335757:SPICUR RS06305
gene id: 1335757:SPICUR_RS06305
uniprot id: U5T797
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1335757:SPICUR RS00355
gene id: 1335757:SPICUR_RS00355
uniprot id: U5T4P6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1335757:SPICUR RS03005
gene id: 1335757:SPICUR_RS03005
uniprot id: U5T2Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

1335757:SPICUR RS07220
gene id: 1335757:SPICUR_RS07220
uniprot id: U5T7R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

1335757:SPICUR RS01275
gene id: 1335757:SPICUR_RS01275
uniprot id: U5T170
names: Similarity
messages: Belongs to the P(II) protein family.

1335757:SPICUR RS05320
gene id: 1335757:SPICUR_RS05320
uniprot id: U5T3M2
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS07335
gene id: 1335757:SPICUR_RS07335
uniprot id: U5T567
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS04795
gene id: 1335757:SPICUR_RS04795
uniprot id: U5T3S9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1335757:SPICUR RS05105
gene id: 1335757:SPICUR_RS05105
uniprot id: U5T702
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

1335757:SPICUR RS02960
gene id: 1335757:SPICUR_RS02960
uniprot id: U5T258
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

1335757:SPICUR RS04930
gene id: 1335757:SPICUR_RS04930
uniprot id: U5T6K0
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS07870
gene id: 1335757:SPICUR_RS07870
uniprot id: U5T825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

1335757:SPICUR RS07750
gene id: 1335757:SPICUR_RS07750
uniprot id: U5T8D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

1335757:SPICUR RS02155
gene id: 1335757:SPICUR_RS02155
uniprot id: U5T1M4
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1335757:SPICUR RS08225
gene id: 1335757:SPICUR_RS08225
uniprot id: U5T528
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1335757:SPICUR RS00070
gene id: 1335757:SPICUR_RS00070
uniprot id: U5T3X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

1335757:SPICUR RS07965
gene id: 1335757:SPICUR_RS07965
uniprot id: U5T5I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

1335757:SPICUR RS06855
gene id: 1335757:SPICUR_RS06855
uniprot id: U5T4G8
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

1335757:SPICUR RS04780
gene id: 1335757:SPICUR_RS04780
uniprot id: U5T6H5
names: Similarity
messages: Belongs to the peptidase S41A family.

1335757:SPICUR RS02570
gene id: 1335757:SPICUR_RS02570
uniprot id: U5T276
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

1335757:SPICUR RS02800
gene id: 1335757:SPICUR_RS02800
uniprot id: U5T5W5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

1335757:SPICUR RS06620
gene id: 1335757:SPICUR_RS06620
uniprot id: U5T444
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

1335757:SPICUR RS09230
gene id: 1335757:SPICUR_RS09230
uniprot id: U5T3V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS03645
gene id: 1335757:SPICUR_RS03645
uniprot id: U5T2T1
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1335757:SPICUR RS07000
gene id: 1335757:SPICUR_RS07000
uniprot id: U5T4A8
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

1335757:SPICUR RS09470
gene id: 1335757:SPICUR_RS09470
uniprot id: U5T980
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1335757:SPICUR RS03300
gene id: 1335757:SPICUR_RS03300
uniprot id: U5T5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

1335757:SPICUR RS04690
gene id: 1335757:SPICUR_RS04690
uniprot id: U5T3R4
names: Similarity
messages: Belongs to the GST superfamily.

1335757:SPICUR RS01270
gene id: 1335757:SPICUR_RS01270
uniprot id: U5T4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

1335757:SPICUR RS00230
gene id: 1335757:SPICUR_RS00230
uniprot id: U5T4I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

1335757:SPICUR RS07990
gene id: 1335757:SPICUR_RS07990
uniprot id: U5T5I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1335757:SPICUR RS00265
gene id: 1335757:SPICUR_RS00265
uniprot id: U5T0Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

1335757:SPICUR RS01885
gene id: 1335757:SPICUR_RS01885
uniprot id: U5T4Z0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1335757:SPICUR RS04445
gene id: 1335757:SPICUR_RS04445
uniprot id: U5T6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

1335757:SPICUR RS02730
gene id: 1335757:SPICUR_RS02730
uniprot id: U5T1Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1335757:SPICUR RS07180
gene id: 1335757:SPICUR_RS07180
uniprot id: U5T4M7
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS03225
gene id: 1335757:SPICUR_RS03225
uniprot id: U5T2L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

1335757:SPICUR RS08645
gene id: 1335757:SPICUR_RS08645
uniprot id: U5T8D5
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

1335757:SPICUR RS07875
gene id: 1335757:SPICUR_RS07875
uniprot id: U5T4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

1335757:SPICUR RS04695
gene id: 1335757:SPICUR_RS04695
uniprot id: U5T6T2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

1335757:SPICUR RS08030
gene id: 1335757:SPICUR_RS08030
uniprot id: U5T844
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1335757:SPICUR RS02615
gene id: 1335757:SPICUR_RS02615
uniprot id: U5T5S7
names: Similarity
messages: Belongs to the acylphosphatase family.

1335757:SPICUR RS01415
gene id: 1335757:SPICUR_RS01415
uniprot id: U5T219
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS01995
gene id: 1335757:SPICUR_RS01995
uniprot id: U5T508
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1335757:SPICUR RS05130
gene id: 1335757:SPICUR_RS05130
uniprot id: U5T708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

1335757:SPICUR RS04265
gene id: 1335757:SPICUR_RS04265
uniprot id: U5T6L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS03360
gene id: 1335757:SPICUR_RS03360
uniprot id: U5T2N6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1335757:SPICUR RS02705
gene id: 1335757:SPICUR_RS02705
uniprot id: U5T2A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

1335757:SPICUR RS08835
gene id: 1335757:SPICUR_RS08835
uniprot id: U5T5J3
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

1335757:SPICUR RS06735
gene id: 1335757:SPICUR_RS06735
uniprot id: U5T4W4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

1335757:SPICUR RS06505
gene id: 1335757:SPICUR_RS06505
uniprot id: U5T4A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

1335757:SPICUR RS08730
gene id: 1335757:SPICUR_RS08730
uniprot id: U5T594
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

1335757:SPICUR RS06000
gene id: 1335757:SPICUR_RS06000
uniprot id: U5T0D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

1335757:SPICUR RS00465
gene id: 1335757:SPICUR_RS00465
uniprot id: U5T492
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

1335757:SPICUR RS04605
gene id: 1335757:SPICUR_RS04605
uniprot id: U5T389
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

1335757:SPICUR RS00300
gene id: 1335757:SPICUR_RS00300
uniprot id: U5T1H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS07695
gene id: 1335757:SPICUR_RS07695
uniprot id: U5T5D2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1335757:SPICUR RS02465
gene id: 1335757:SPICUR_RS02465
uniprot id: U5T1T2
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS05070
gene id: 1335757:SPICUR_RS05070
uniprot id: U5T3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

1335757:SPICUR RS01795
gene id: 1335757:SPICUR_RS01795
uniprot id: U5T4X6
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

1335757:SPICUR RS02145
gene id: 1335757:SPICUR_RS02145
uniprot id: U5T5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS03915
gene id: 1335757:SPICUR_RS03915
uniprot id: U5T622
names: Similarity
messages: Belongs to the bacterial secretin family.

1335757:SPICUR RS04520
gene id: 1335757:SPICUR_RS04520
uniprot id: U5T6D2
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

1335757:SPICUR RS00055
gene id: 1335757:SPICUR_RS00055
uniprot id: U5T0U5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

1335757:SPICUR RS01675
gene id: 1335757:SPICUR_RS01675
uniprot id: U5T1E2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1335757:SPICUR RS05670
gene id: 1335757:SPICUR_RS05670
uniprot id: U5T7F0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS09165
gene id: 1335757:SPICUR_RS09165
uniprot id: U5T8M0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1335757:SPICUR RS01340
gene id: 1335757:SPICUR_RS01340
uniprot id: U5T207
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

1335757:SPICUR RS06690
gene id: 1335757:SPICUR_RS06690
uniprot id: U5T7V8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS00380
gene id: 1335757:SPICUR_RS00380
uniprot id: U5T4Q2
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00470
gene id: 1335757:SPICUR_RS00470
uniprot id: U5T0V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

1335757:SPICUR RS03310
gene id: 1335757:SPICUR_RS03310
uniprot id: U5T2N0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS03060
gene id: 1335757:SPICUR_RS03060
uniprot id: U5T643
names: Similarity
messages: Belongs to the HesB/IscA family.

1335757:SPICUR RS01105
gene id: 1335757:SPICUR_RS01105
uniprot id: U5T514
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

1335757:SPICUR RS05110
gene id: 1335757:SPICUR_RS05110
uniprot id: U5T6N0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS06110
gene id: 1335757:SPICUR_RS06110
uniprot id: U5T3V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

1335757:SPICUR RS09405
gene id: 1335757:SPICUR_RS09405
uniprot id: U5T5K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

1335757:SPICUR RS02690
gene id: 1335757:SPICUR_RS02690
uniprot id: U5T5U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1335757:SPICUR RS00475
gene id: 1335757:SPICUR_RS00475
uniprot id: U5T161
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

1335757:SPICUR RS05075
gene id: 1335757:SPICUR_RS05075
uniprot id: U5T3X9
names: Cofactor
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

1335757:SPICUR RS09395
gene id: 1335757:SPICUR_RS09395
uniprot id: U5T966
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1335757:SPICUR RS08400
gene id: 1335757:SPICUR_RS08400
uniprot id: U5T5T6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

1335757:SPICUR RS01300
gene id: 1335757:SPICUR_RS01300
uniprot id: U5T174
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

1335757:SPICUR RS02755
gene id: 1335757:SPICUR_RS02755
uniprot id: U5T1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

1335757:SPICUR RS07640
gene id: 1335757:SPICUR_RS07640
uniprot id: U5T4X0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

1335757:SPICUR RS04995
gene id: 1335757:SPICUR_RS04995
uniprot id: U5T3G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1335757:SPICUR RS07770
gene id: 1335757:SPICUR_RS07770
uniprot id: U5T4Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

1335757:SPICUR RS04825
gene id: 1335757:SPICUR_RS04825
uniprot id: U5T6V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1335757:SPICUR RS03210
gene id: 1335757:SPICUR_RS03210
uniprot id: U5T667
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

1335757:SPICUR RS03220
gene id: 1335757:SPICUR_RS03220
uniprot id: U5T2B2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS01055
gene id: 1335757:SPICUR_RS01055
uniprot id: U5T506
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS08115
gene id: 1335757:SPICUR_RS08115
uniprot id: U5T0R2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1335757:SPICUR RS00595
gene id: 1335757:SPICUR_RS00595
uniprot id: U5T4T8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

1335757:SPICUR RS05395
gene id: 1335757:SPICUR_RS05395
uniprot id: U5T3P0
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

1335757:SPICUR RS03330
gene id: 1335757:SPICUR_RS03330
uniprot id: U5T2C9
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1335757:SPICUR RS00555
gene id: 1335757:SPICUR_RS00555
uniprot id: U5T172
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1335757:SPICUR RS03610
gene id: 1335757:SPICUR_RS03610
uniprot id: U5T5Y1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

1335757:SPICUR RS03515
gene id: 1335757:SPICUR_RS03515
uniprot id: U5T2R1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1335757:SPICUR RS08850
gene id: 1335757:SPICUR_RS08850
uniprot id: U5T8H1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS04220
gene id: 1335757:SPICUR_RS04220
uniprot id: U5T6K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1335757:SPICUR RS00985
gene id: 1335757:SPICUR_RS00985
uniprot id: U5T1E4
names: Similarity
messages: Belongs to the DapA family.

1335757:SPICUR RS01850
gene id: 1335757:SPICUR_RS01850
uniprot id: U5T3Q7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1335757:SPICUR RS05195
gene id: 1335757:SPICUR_RS05195
uniprot id: U5T3J9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1335757:SPICUR RS00170
gene id: 1335757:SPICUR_RS00170
uniprot id: U5T0K5
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

1335757:SPICUR RS02065
gene id: 1335757:SPICUR_RS02065
uniprot id: U5T5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS01360
gene id: 1335757:SPICUR_RS01360
uniprot id: U5T1K3
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

1335757:SPICUR RS08140
gene id: 1335757:SPICUR_RS08140
uniprot id: U5T0F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1335757:SPICUR RS01330
gene id: 1335757:SPICUR_RS01330
uniprot id: U5T178
names: Similarity
messages: Belongs to the MlaA family.

1335757:SPICUR RS06125
gene id: 1335757:SPICUR_RS06125
uniprot id: U5T7L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

1335757:SPICUR RS04435
gene id: 1335757:SPICUR_RS04435
uniprot id: U5T354
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

1335757:SPICUR RS03170
gene id: 1335757:SPICUR_RS03170
uniprot id: U5T2L1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1335757:SPICUR RS04020
gene id: 1335757:SPICUR_RS04020
uniprot id: U5T0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

1335757:SPICUR RS00350
gene id: 1335757:SPICUR_RS00350
uniprot id: U5T1I8
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

1335757:SPICUR RS03595
gene id: 1335757:SPICUR_RS03595
uniprot id: U5T2S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1335757:SPICUR RS00130
gene id: 1335757:SPICUR_RS00130
uniprot id: U5T0W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS03880
gene id: 1335757:SPICUR_RS03880
uniprot id: U5T3C8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1335757:SPICUR RS01535
gene id: 1335757:SPICUR_RS01535
uniprot id: U5T1N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

1335757:SPICUR RS03865
gene id: 1335757:SPICUR_RS03865
uniprot id: U5T614
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

1335757:SPICUR RS00415
gene id: 1335757:SPICUR_RS00415
uniprot id: U5T0U4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1335757:SPICUR RS02475
gene id: 1335757:SPICUR_RS02475
uniprot id: U5T2K0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1335757:SPICUR RS05260
gene id: 1335757:SPICUR_RS05260
uniprot id: U5T6Q3
names: Cofactor
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

1335757:SPICUR RS08165
gene id: 1335757:SPICUR_RS08165
uniprot id: U5T4B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1335757:SPICUR RS00515
gene id: 1335757:SPICUR_RS00515
uniprot id: U5T4S5
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1335757:SPICUR RS04640
gene id: 1335757:SPICUR_RS04640
uniprot id: U5T3Q6
names: Similarity
messages: Belongs to the SfsA family.

1335757:SPICUR RS05895
gene id: 1335757:SPICUR_RS05895
uniprot id: U5T419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

1335757:SPICUR RS02445
gene id: 1335757:SPICUR_RS02445
uniprot id: U5T251
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1335757:SPICUR RS00245
gene id: 1335757:SPICUR_RS00245
uniprot id: U5T0Y5
names: Similarity
messages: Belongs to the DprA/Smf family.

1335757:SPICUR RS00100
gene id: 1335757:SPICUR_RS00100
uniprot id: U5T0J0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

1335757:SPICUR RS05510
gene id: 1335757:SPICUR_RS05510
uniprot id: U5T3U8
names: Similarity
messages: Belongs to the UPF0047 family.

1335757:SPICUR RS04645
gene id: 1335757:SPICUR_RS04645
uniprot id: U5T6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

1335757:SPICUR RS04700
gene id: 1335757:SPICUR_RS04700
uniprot id: U5T6G4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1335757:SPICUR RS01005
gene id: 1335757:SPICUR_RS01005
uniprot id: U5T134
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS03795
gene id: 1335757:SPICUR_RS03795
uniprot id: U5T6F3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1335757:SPICUR RS02310
gene id: 1335757:SPICUR_RS02310
uniprot id: U5T229
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

1335757:SPICUR RS07065
gene id: 1335757:SPICUR_RS07065
uniprot id: U5T819
names: Subcellular Location Annotation
messages: Membrane

1335757:SPICUR RS00610
gene id: 1335757:SPICUR_RS00610
uniprot id: U5T0B2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

1335757:SPICUR RS08675
gene id: 1335757:SPICUR_RS08675
uniprot id: U5T587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Membrane

1335757:SPICUR RS01780
gene id: 1335757:SPICUR_RS01780
uniprot id: U5T1T0
names: Similarity
messages: Belongs to the CFA/CMAS family.

1335757:SPICUR RS09415
gene id: 1335757:SPICUR_RS09415
uniprot id: U5T689
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

1335757:SPICUR RS04410
gene id: 1335757:SPICUR_RS04410
uniprot id: U5T349
names: Similarity
messages: Belongs to the citrate synthase family.

1335757:SPICUR RS01465
gene id: 1335757:SPICUR_RS01465
uniprot id: U5T228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

1335757:SPICUR RS01930
gene id: 1335757:SPICUR_RS01930
uniprot id: U5T5G3
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS06225
gene id: 1335757:SPICUR_RS06225
uniprot id: U5T7N5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1335757:SPICUR RS02970
gene id: 1335757:SPICUR_RS02970
uniprot id: U5T2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1335757:SPICUR RS06090
gene id: 1335757:SPICUR_RS06090
uniprot id: U5T446
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1335757:SPICUR RS04920
gene id: 1335757:SPICUR_RS04920
uniprot id: U5T3V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

1335757:SPICUR RS07850
gene id: 1335757:SPICUR_RS07850
uniprot id: U5T4S4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1335757:SPICUR RS04915
gene id: 1335757:SPICUR_RS04915
uniprot id: U5T3F1
names: Similarity
messages: Belongs to the skp family.

1335757:SPICUR RS07265
gene id: 1335757:SPICUR_RS07265
uniprot id: U5T848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1335757:SPICUR RS09345
gene id: 1335757:SPICUR_RS09345
uniprot id: U5T956
names: Similarity
messages: Belongs to the OsmC/Ohr family.

1335757:SPICUR RS03230
gene id: 1335757:SPICUR_RS03230
uniprot id: U5T326
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS06495
gene id: 1335757:SPICUR_RS06495
uniprot id: U5T7C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1335757:SPICUR RS08630
gene id: 1335757:SPICUR_RS08630
uniprot id: U5T4C6
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

1335757:SPICUR RS01760
gene id: 1335757:SPICUR_RS01760
uniprot id: U5T279
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

1335757:SPICUR RS07960
gene id: 1335757:SPICUR_RS07960
uniprot id: U5T527
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1335757:SPICUR RS07035
gene id: 1335757:SPICUR_RS07035
uniprot id: U5T512
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1335757:SPICUR RS09310
gene id: 1335757:SPICUR_RS09310
uniprot id: U5T5Q9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

1335757:SPICUR RS06600
gene id: 1335757:SPICUR_RS06600
uniprot id: U5T4C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

1335757:SPICUR RS04540
gene id: 1335757:SPICUR_RS04540
uniprot id: U5T6Q6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1335757:SPICUR RS02635
gene id: 1335757:SPICUR_RS02635
uniprot id: U5T2M8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

1335757:SPICUR RS09465
gene id: 1335757:SPICUR_RS09465
uniprot id: U5T696
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

1335757:SPICUR RS07975
gene id: 1335757:SPICUR_RS07975
uniprot id: U5T837
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1335757:SPICUR RS08980
gene id: 1335757:SPICUR_RS08980
uniprot id: U5T8J2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

1335757:SPICUR RS03190
gene id: 1335757:SPICUR_RS03190
uniprot id: U5T5R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

1335757:SPICUR RS07380
gene id: 1335757:SPICUR_RS07380
uniprot id: U5T4R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

1335757:SPICUR RS01540
gene id: 1335757:SPICUR_RS01540
uniprot id: U5T241
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

1335757:SPICUR RS04510
gene id: 1335757:SPICUR_RS04510
uniprot id: U5T3N1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

1335757:SPICUR RS08640
gene id: 1335757:SPICUR_RS08640
uniprot id: U5T8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.